Digital Commons Network^™

Cortical Microstructural Changes Associated With Treated Aphasia Recovery, Allen J. Chang, Janina Wilmonskoetter, Julius Fridriksson, Emilie R. Mckinnon, Lorelei P. Johnson, Alexandra Basilakos, Jens H. Jensen, Chris Rorden, Leonardo Bonilha

Faculty Publications

Objectives

To investigate the hypothesis that language recovery in post-stroke aphasia is associated with structural brain changes.

Methods

We evaluated whether treatment-induced improvement in naming is associated with reorganization of tissue microstructure within residual cortical regions. To this end, we performed a retrospective longitudinal treatment study using comprehensive language-linguistic assessments and diffusion MRI sequences optimized for the assessment of complex microstructure (diffusional kurtosis imaging) to evaluate the relationship between language treatment response and cortical changes in 26 individuals with chronic stroke-induced aphasia. We employed elastic net statistical models controlling for baseline factors including age, sex, and time since the stroke, …

Lehi's Dream: Nephi's Blueprint, Noel B. Reynolds

Faculty Publications

This essay harnesses the late twentieth-century discovery of Hebrew rhetoric by Bible scholars to identify Lehi’s dream as the foundation of the carefully constructed unity in Nephi’s writings and to identify previously unrecognized elements of that dream that are distributed throughout his final work. All the teachings and prophecies in First and Second Nephi are shown to derive from that dream/vision. Further, the entirety of Nephi’s writings in the small plates are shown to be a tightly designed rhetorical production that establishes the centrality of Christ’s identity, mission, and teachings for current and future generations of Lehi’s descendants and ultimately …

Lehi And Nephi As Trained Manassite Scribes, Noel B. Reynolds

Faculty Publications

This paper brings contemporary ANE scholarship in several fields together to construct an updated starting point for interpretation of the teachings of the Book of Mormon. It assembles findings from studies of ancient scribal culture, historical linguistics and epigraphy, Hebrew rhetoric, and the history and archaeology of Mesopotamia, Egypt, and the Levant, together with the traditions of ancient Israel to construct a contextualized perspective for understanding Lehi, Nephi, and their scribal training as they would have been understood by their contemporaries. Lehi and Nephi are shown to be the beneficiaries of the most advanced scribal training available in 7th century …

Electrochemical Micro-Aptasensors For Exosome Detection Based On Hybridization Chain Reaction Amplification, Wenfen Zhang, Zhenhua Tian, Shujie Yang, Joseph Rich, Shuaiguo Zhao, Mikael Klingeborn, Po-Hsun Huang, Zhishang Li, Alexander Stout, Quinn Murphy, Edward Patz, Shusheng Zhang, Guozhen Liu, Tony Jun Huang

Faculty Publications

Exosomes are cell-derived nanovesicles that have recently gained popularity as potential biomarkers in liquid biopsies due to the large amounts of molecular cargo they carry, such as nucleic acids and proteins. However, most existing exosome-based analytical sensing methods struggle to achieve high sensitivity and high selectivity simultaneously. In this work, we present an electrochemical micro-aptasensor for the highly sensitive detection of exosomes by integrating a micropatterned electrochemical aptasensor and a hybridization chain reaction (HCR) signal amplification method. Specifically, exosomes are enriched on CD63 aptamer-functionalized electrodes and then recognized by HCR products with avidin-horseradish peroxidase (HRP) attached using EpCAM aptamers as …

Seed Treatment With Jasmonic Acid And Methyl Jasmonate Induces Resistance To Insects But Reduces Plant Growth And Yield In Rice, Oryza Sativa, Santhi Bhavanam, Michael Stout

Faculty Publications

When applied exogenously to plants, jasmonates [i.e., jasmonic acid (JA) and methyl jasmonate (MeJA)] increase plant resistance against herbivores, and their use in pest management has been suggested. For integration into pest management programs, the benefits of the resistance induced by jasmonates must outweigh the costs of jasmonates on plant growth and yield. A previous field study in rice found that seed treatment with MeJA reduced densities of the rice water weevil, Lissorhoptrus oryzophilus, but also reduced plant growth. Yields from MeJA plots were similar to yields from control plots. Because this study was conducted under field conditions with natural …

Auditing Non-Gaap Measures: Signaling More Than Intended, Spencer B. Anderson, Jessen L. Hobson, Ryan D. Sommerfeldt

Faculty Publications

Many companies regularly disclose non-GAAP performance measures to communicate firm-specific information that does not fit within the mold of GAAP reporting. However, these non- GAAP measures may have low information content or even be misleading to investors. Thus, the question arises of whether auditors should play a larger role in the reporting of non-GAAP measures, which currently are not audited. We run an experiment to provide ex ante evidence on the effect of auditing non-GAAP measures. Specifically, we present investor-participants with a non- GAAP measure that should be used when making investment judgments (more informative) or should not be used …

Cocrfeni High-Entropy Alloy As An Enhanced Hydrogen Evolution Catalyst In An Acidic Solution, Frank Mckay, Yuxin Fang, Orhan Kizilkaya, Prashant Singh, Duane D. Johnson, Amitava Roy, David P. Young, Phillip T. Sprunger, John C. Flake, William A. Shelton, Ye Xu

Faculty Publications

High-entropy alloys (HEAs) have intriguing material properties, but their potential as catalysts has not been widely explored. Based on a concise theoretical model, we predict that the surface of a quaternary HEA of base metals, CoCrFeNi, should go from being nearly fully oxidized except for pure Ni sites when exposed to O2 to being partially oxidized in an acidic solution under cathodic bias, and that such a partially oxidized surface should be more active for the electrochemical hydrogen evolution reaction (HER) in acidic solutions than all the component metals. These predictions are confirmed by electrochemical and surface science experiments: the …

Independent Contributions Of Structural And Functional Connectivity: Evidence From A Stroke Model, Lynsey M. Keator, Grigori Yourganov, Alexandra Basilakos, Argye E. Hillis, Gregory Hickok, Leonardo Bonilha, Chris Rorden, Julius Fridriksson

Faculty Publications

Altered functional connectivity is related to severity of language impairment in poststroke aphasia. However, it is not clear whether this finding specifically reflects loss of functional coherence, or more generally, is related to decreased structural connectivity due to cortical necrosis. The aim of the current study was to investigate this issue by factoring out structural connectivity from functional connectivity measures and then relating the residual data to language performance poststroke. Ninety-seven participants with a history of stroke were assessed using language impairment measures (Auditory Verbal Comprehension and Spontaneous Speech scores from the Western Aphasia Battery-Revised) and MRI (structural, diffusion tensor …

Adaptation Of The Agency For Healthcare Research And Quality’S ‘Hospital Survey On Patient Safety Culture’ To The Bosnia And Herzegovina Context, Šehad Draganović, Guido Offermanns, Rachel E. Davis

Faculty Publications

OBJECTIVES: Measuring staff perspectives on patient safety culture (PSC) can identify areas of concern that, if addressed, could lead to improvements in healthcare. To date, there is no validated measure to assess PSC that has been tested and adapted for use in Bosnia and Herzegovina (BiH). This research addresses the gap in the evidence through the psychometric assessment of the Agency for Healthcare Research and Quality's: 'Hospital Survey on Patient Safety Culture' (HSOPSC), to determine its suitability for the health system in BiH. SETTING: Nine hospitals. PARTICIPANTS: Healthcare professionals (n=1429); nurse (n=823), doctors (n=328), other clinical personnel (n=111), non-clinical personnel …

Racism As Public Health Crisis: Assessment And Review Of Municipal Declarations And Resolutions Across The United States, Dara D. Mendez, Jewel Scott Phd, Rn, Fnp-C, Linda Adodoadji, Christina Toval, Monica Mcneil, Mahima Sindhu

Faculty Publications

Racism in the United States has been cited as a key driver of racial health inequities. Racism as a public health crisis has been in the forefront, particularly with respect to state and municipal governments that have developed legislation, resolutions, and declarations. This policy brief includes a review of resolutions and declarations across the US related to Racism as a Public Health Crisis through the end of September 2020. There were 125 resolutions reviewed for content related to the history of racism, reference to racial health equity data, content related to action steps or implementation, and any accompanying funding or …

Augmenting The Space Domain Awareness Ground Architecture Via Decision Analysis And Multi-Objective Optimization, Albert R. Vasso, Richard G. Cobb, John M. Colombi, Bryan D. Little, David R. Meyer

Faculty Publications

Purpose — The US Government is challenged to maintain pace as the world’s de facto provider of space object cataloging data. Augmenting capabilities with nontraditional sensors present an expeditious and low-cost improvement. However, the large tradespace and unexplored system of systems performance requirements pose a challenge to successful capitalization. This paper aims to better define and assess the utility of augmentation via a multi-disiplinary study. Design/methodology/approach — Hypothetical telescope architectures are modeled and simulated on two separate days, then evaluated against performance measures and constraints using multi-objective optimization in a heuristic algorithm. Decision analysis and Pareto optimality identifies a set …

Racism As Public Health Crisis: Assessment And Review Of Municipal Declarations And Resolutions Across The United States, Dara D. Mendez, Jewel Scott Phd, Rn, Fnp-C, Linda Adodoadji, Christina Toval, Monica Mcneil, Mahima Sindhu

Faculty Publications

Racism in the United States has been cited as a key driver of racial health inequities. Racism as a public health crisis has been in the forefront, particularly with respect to state and municipal governments that have developed legislation, resolutions, and declarations. This policy brief includes a review of resolutions and declarations across the US related to Racism as a Public Health Crisis through the end of September 2020. There were 125 resolutions reviewed for content related to the history of racism, reference to racial health equity data, content related to action steps or implementation, and any accompanying funding or …

Normalization Of Muscle Strength Measurements In The Assessment Of Cardiometabolic Risk Factors In Adolescents, Tiago Rodrigues De Lima, Xuemei Sui M.D., M.P.H., Ph.D., Diego Augusto Santos Silva

Faculty Publications

Muscle strength (MS) has been associated with cardiometabolic risk factors (CMR) in adolescents, however, the impact attributed to body size in determining muscle strength or whether body size acts as a confounder in this relationship remains controversial. We investigated the association between absolute MS and MS normalized for body size with CMR in adolescents. This was a cross-sectional study comprising 351 adolescents (44.4% male; 16.6 ± 1.0 years) from Brazil. MS was assessed by handgrip and normalized for body weight, body mass index (BMI), height, and fat mass. CMR included obesity, high blood pressure, dyslipidemia, glucose imbalance, and high inflammation …

Local Translation Across Neural Development: A Focus On Radial Glial Cells, Axons, And Synaptogenesis, Manasu Agrawal, Kristy Welshhans

Faculty Publications

In the past two decades, significant progress has been made in our understanding of mRNA localization and translation at distal sites in axons and dendrites. The existing literature shows that local translation is regulated in a temporally and spatially restricted manner and is critical throughout embryonic and post-embryonic life. Here, recent key findings about mRNA localization and local translation across the various stages of neural development, including neurogenesis, axon development, and synaptogenesis, are reviewed. In the early stages of development, mRNAs are localized and locally translated in the endfeet of radial glial cells, but much is still unexplored about their …

Covid-19 Protocols In Academic Libraries In Canada And The United States: An Acrl Val Report, Holt Zaugg, Jeffrey Bullington, Stephanie Farne, Beate Gersch, Jo Ann Murphy, Lamonica Sanford

Faculty Publications

In the Fall of 2020, as the COVID-19 pandemic raged throughout the world, educational institutions pivoted to online learning and supporting services, especially those found in academic libraries, adjusted. To better understand measures taken by academic libraries in Canada and the United States, the Association of College & Research Libraries’ (ACRL) Value of Academic Libraries (VAL) committee formed a subcommittee to examine how academic libraries adjusted and provided services to their respective institutions during COVID-19 pandemic. This report is the culmination of this examination.

Covid-19 Disrupted Provision And Utilization Of Health And Nutrition Services In Uttar Pradesh, India: Insights From Service Providers, Household Phone Surveys, And Administrative Data, Phuong H. Nguyen, Shivani Kachwaha, Anjali Pant, Lan M. Tran, Monika Walia, Sebanti Ghosh, Praveen K. Sharma, Jessica Escobar-Alegria, Edward A. Frongillo Jr., Purnima Menon, Rasmi Avula

Faculty Publications

BACKGROUND: The coronavirus (COVID-19) pandemic may substantially affect health systems, but little primary evidence is available on disruption of health and nutrition services. OBJECTIVES: This study aimed to 1) determine the extent of disruption in provision and utilization of health and nutrition services induced by the pandemic in Uttar Pradesh, India; and 2) identify how adaptations were made to restore service provision in response to the pandemic. METHODS: We conducted longitudinal surveys with frontline workers (FLWs, n = 313) and mothers of children < 2 y old (n = 659) in December 2019 (in-person) and July 2020 (by phone). We also interviewed block-level managers and obtained administrative data. We examined changes in service provision and utilization using Wilcoxon matched-pairs signed-rank tests. RESULTS: Compared with prepandemic, service provision reduced substantially during lockdown (83-98 percentage points, pp), except for home visits and take-home rations (∼ 30%). Most FLWs (68%-90%) restored service provision in July 2020, except for immunization and hot cooked meals (< 10%). Administrative data showed similar patterns of disruption and restoration. FLW fears, increased workload, inadequate personal protective equipment (PPE), and manpower shortages challenged service provision. Key adaptations made to provide services were delivering services to beneficiary homes (∼ 40%-90%), social distancing (80%), and using PPE (40%-50%) and telephones for communication (∼ 20%). On the demand side, service utilization reduced substantially (40-80 pp) during the lockdown, but about half of mothers received home visits and food supplementation. Utilization for most services did not improve after the lockdown, bearing the challenges of limited travel (30%), nonavailability of services (26%), and fear of catching the virus when leaving the house (22%) or meeting service providers (14%). CONCLUSIONS: COVID-19 disrupted the provision and use of health and nutrition services in Uttar Pradesh, India, despite adaptations to restore services. Strengthening logistical support, capacity enhancement, performance management, and demand creation are needed to improve service provision and utilization during and post-COVID-19.

An Assessment Of Government Capacity Building To Restrict The Marketing Of Unhealthy Food And Non-Alcoholic Beverage Products To Children In The Region Of The Americas, Sofía Rincón-Gallardo Patiño, Fabio Da Silva Gomes, Steven Constantinou, Robin Lemaire, Valisa E. Hedrick, Elena L. Serrano, Vivica I. Kraak

Faculty Publications

No abstract provided.

The Brass Plates In Context: A Book Of Mormon Backstory, Noel B. Reynolds

Faculty Publications

This paper brings contemporary ANE scholarship in several fields together with the ancient scriptures restored through Joseph Smith to construct an updated starting point for interpretation of the teachings of the Book of Mormon. It assembles findings from studies of ancient scribal culture, historical linguistics and epigraphy, and the history and archaeology of Mesopotamia, Egypt, and the Levant, together with the traditions of ancient Israel and the ancient scriptures restored to Joseph Smith, to construct a contextualized perspective for understanding Lehi, Nephi, and the Brass Plates as they would have been understood by their contemporaries—as prominent bearers of the Josephite …

Individualized Response To Semantic Versus Phonological Aphasia Therapies In Stroke, Sigfus Kristinsson, Alexandra Basilakos, Jordan Elm, Leigh Ann Spell, Leonardo Bonilha, Chris Rorden, Dirk Den Ouden Ph.D., Christy Cassarly, Souvik Sen, Argye Hillis, Gregory Hickok, Julius Fridriksson Ph.D.

Faculty Publications

Attempts to personalize aphasia treatment to the extent where it is possible to reliably predict individual response to a particular treatment have yielded inconclusive results. The current study aimed to (i) compare the effects of phonologically versus semantically focussed naming treatment and (ii) examine biographical and neuropsychological baseline factors predictive of response to each treatment. One hundred and four individuals with chronic post-stroke aphasia underwent 3 weeks of phonologically focussed treatment and 3 weeks of semantically focussed treatment in an unblinded cross-over design. A linear mixed-effects model was used to compare the effects of treatment type on proportional change in …

Factors Influencing Physicians’ Continuous Blogging: A Survey, I. Chiu Chang, Kuei Chen Cheng, Hui Mei Hsu, David C. Yen

Faculty Publications

Background: Health information can be more easily transmitted and diffused through the Internet, but questionable online health information often misinforms patients. Physicians have a duty to inform patients how to achieve positive health outcomes. Many physicians often write blogs to provide patients with the right health information. However, most articles available on this sub-ject only describe the blog phenomena without providing a theoretical background and an empirical analysis of doctors using blogs. Methods: This study based on social cognitive theory (SCT) explores the factors influencing physicians’ intention of continuously blogging. A total of 887 physician blog-gers were invited to participate …

Probiotics In Prevention And Treatment Of Covid-19: Current Perspective And Future Prospects, Shilia Jacob Kurian, Mazhuvancherry Kesavan Unnikrishnan, Sonal Sekhar Miraj, Debasis Bagchi, Mithu Banerjee, B. Shrikar Reddy, Gabriel Sunil Rodrigues, Mohan K. Manu, Kavitha Saravu, Chiranjay Mukhopadhyay, Mahadev Rao

Faculty Publications

Saving lives and flattening the curve are the foremost priorities during the ongoing pandemic spread of SARS-CoV-2. Developing cutting-edge technology and collating available evidence would support frontline health teams. Nutritional adequacy improves general health and immunity to prevent and assuage infections. This review aims to outline the potential role of probiotics in fighting the COVID-19 by covering recent evidence on the association between microbiota, probiotics, and COVID-19, the role of probiotics as an immune-modulator and antiviral agent. The high basic reproduction number (R0) of SARS-CoV-2, absence of conclusive remedies, and the pleiotropic effect of probiotics in fighting influenza and other …

Resource Theory Of Unextendibility And Nonasymptotic Quantum Capacity (), Eneet Kaur, Siddhartha Das, Mark M. Wilde, Andreas Winter

Faculty Publications

In this paper, we introduce the resource theory of unextendibility as a relaxation of the resource theory of entanglement. The free states in this resource theory are the -extendible states, associated with the inability to extend quantum entanglement in a given quantum state to multiple parties. The free channels are -extendible channels, which preserve the class of -extendible states. We define several quantifiers of unextendibility by means of generalized divergences and establish their properties. By utilizing this resource theory, we obtain nonasymptotic upper bounds on the rate at which quantum communication or entanglement preservation is possible over a finite number …

Effect Of Disclosed Information On Product Liking, Emotional Profile, And Purchase Intent: A Case Of Chocolate Brownies Containing Edible-Cricket Protein, Cristhiam E. Gurdian, Damir D. Torrico, Bin Li, Georgianna Tuuri, Witoon Prinyawiwatkul

Faculty Publications

Edible insects, a sustainable and nutritious alternative to conventionally derived proteins, are unfamiliar to Westerners and often associated with negative sentiments. Edible-cricket protein (ECP) added to chocolate brownies (CB) [0% ECP = CBWO (without) vs. 6% w/w ECP = CBW (with)], and disclosed information [no ECP added = (−) vs. ECP with benefits = (+), ECP− and ECP+, respectively] yielded four CB treatments (CBWO−, CBWO+, CBW−, and CBW+). Subjects (n = 112 female and n = 98 male) rated liking, selected emotions before-and after-tasting, and determined consumption (CI) and purchase intent (PI) after tasting. Likings were analyzed with mixed-effects ANOVA …

The Neural Underpinnings Of Processing Newly Taught Semantic Information: The Role Of Retrieval Practice, Eileen Haebig, Laurence B. Leonard, Patricia Deevy, Jennifer Schumaker, Jeffrey D. Karpicke, Christine Weber

Faculty Publications

Purpose: Recent behavioral studies have demonstrated the effectiveness of implementing retrieval practice into learning tasks for children. Such approaches have revealed that repeated spaced retrieval (RSR) is particularly effective in promoting children’s learning of word form and meaning information. This study further examines how retrieval practice enhances learning of word meaning information at the behavioral and neural levels. Method: Twenty typically developing preschool children were taught novel words using an RSR learning schedule for some words and an immediate retrieval (IR) learning schedule for other words. In addition to the label, children were taught two arbitrary semantic features for each …

Range-Wide Population Genetic Analysis Of Seaside Sparrows (Ammospiza Maritima) Supports At Least Five Distinct Population Segments That Do Not Align With Current Subspecies Descriptions, Kathryn E.C. Davis, Amie E. Settlecowski, Mackenzie R. Roeder, Carolyn Enloe, Thomas Virzi, Margaret E. Hunter, Stefan Woltmann, Sabrina S. Taylor

Faculty Publications

As an obligate salt marsh species, Seaside Sparrows (Ammospiza maritima) are vulnerable to numerous threats including climate change, coastal erosion, sea-level rise, and both natural and anthropogenic disasters. Of the 9 recognized subspecies, 2 are extinct and 1 is endangered. Previous genetic analyses of mitochondrial DNA (mtDNA) and microsatellite loci showed that current taxonomy does not accurately reflect underlying genetic diversity, with possible consequences for the distribution of conservation resources. To further inform Seaside Sparrow management, we comprehensively describe genetic structure among 24 range-wide sampling locations that include all extant subspecies. We inferred population structure from several thousand single-nucleotide polymorphisms …

Honeycomb Structures In Magnetic Fields, Becker Simon, Rui Han, Svetlana Jitomirskaya, Maciej Zworski

Faculty Publications

We consider the nearest-neighbour tight binding model of the honeycomb lattice in magnetic fields and discover surprizing new analytical results that fully explain fractal spectra and experimentally observed asymmetries in the density of states of molecular graphene.We describe a fractal Cantor spectrum for irrational magnetic flux through a honeycomb, and establish the existence of zero energy Dirac cones for each rational flux with fully explicit estimates on the cone angle. Our results give a substantially more refined description of subtleties in the de Haas-van Alphen and quantum Hall effects, and provide the first quantitative bounds on transport coefficients for the …

Reducible Fermi Surface For Multi-Layer Quantum Graphs Including Stacked Graphene, Lee Fisher, Wei Li, Stephen P. Shipman

Faculty Publications

We construct two types of multi-layer quantum graphs (Schrödinger operators on metric graphs) for which the dispersion function of wave vector and energy is proved to be a polynomial in the dispersion function of the single layer. This leads to the reducibility of the algebraic Fermi surface, at any energy, into several components. Each component contributes a set of bands to the spectrum of the graph operator. When the layers are graphene, AA-, AB-, and ABC-stacking are allowed within the same multi-layer structure. One of the tools we introduce is a surgery-type calculus for obtaining the dispersion function for a …

The Effects Of Ceria Loading On Three-Way Catalysts For Passive Scr Operation, Calvin R. Thomas, Josh A. Pihl, Vitaly Y. Prikhodko, Michelle K. Kidder, Jochen A. Lauterbach, Todd J. Toops

Faculty Publications

Passive SCR systems, which employ both a three-way catalyst and SCR catalyst, are effective for the reduction of nitrogen oxide (NOx) emissions from lean burn gasoline engines. However, questions remain regarding the effect of three-way catalyst formulations on their performance in these systems. Here, Pd/CeOx/Al2O3 catalysts with variable CeOx loading were synthesized, characterized, and evaluated to determine the effects of CeOx on catalyst performance. While a small amount of ceria was beneficial for promoting essential reactions, excess ceria was detrimental due to the increase in oxygen storage capacity. Additionally, insights into potential reaction pathways for NH3 production were determined.

Working While Mothering During The Pandemic And Beyond, Nicole Buonocore Porter

Faculty Publications

Although combining work and family has never been easy for women, working while mothering during the pandemic was close to impossible. When COVID-19 caused most workplaces to shut down, many women were laid off. But many women were forced to work from home alongside their children, who could not attend daycare or school. Mothers tried valiantly to combine a full day’s work on top of caring for young children and helping school-aged children with remote school. But many found this balance difficult, leading to women’s lowest workforce participation rate in over forty years. And even women who did not quit …

An Adaptive Data-Driven Controller For Underwater Manipulators With Variable Payload, Ignacio Carlucho, Dylan W. Stephens, Corina Barbalata

Faculty Publications

The underwater environment poses a complex problem for developing control systems for underwater manipulators. Modeling the system is a complicated and costly process due to the highly nonlinear dynamics and the presence of unknown hydrodynamical effects. Furthermore, manipulators are usually deployed on Autonomous Underwater Vehicles (AUVs) which further influence and change the dynamics of the arm. This is aggravated in underwater operations where manipulating different objects is necessary. These diverse manipulation tasks introduce external disturbances to the system and can lead to a fast degradation of the control system performance. In this article, we propose a novel adaptive controller for …