Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Social and Behavioral Sciences (5476)
- Education (4376)
- Engineering (4148)
- Physical Sciences and Mathematics (3531)
- Arts and Humanities (3496)
-
- Life Sciences (3161)
- Medicine and Health Sciences (2239)
- Psychology (1660)
- Electrical and Computer Engineering (1170)
- Educational Leadership (1083)
- Sociology (973)
- Educational Administration and Supervision (791)
- Chemistry (781)
- History (716)
- Civil and Environmental Engineering (663)
- Communication (653)
- Mechanical Engineering (647)
- Biology (633)
- Environmental Sciences (627)
- Physics (618)
- Computer Sciences (567)
- Higher Education (552)
- Business (546)
- Animal Sciences (502)
- Biochemistry, Biophysics, and Structural Biology (488)
- Curriculum and Instruction (479)
- Public Affairs, Public Policy and Public Administration (453)
- Teacher Education and Professional Development (448)
- Clinical Psychology (440)
- Educational Assessment, Evaluation, and Research (429)
- Institution
-
- University of Mississippi (8605)
- University of Central Florida (6833)
- South Dakota State University (4806)
- University of Louisville (4691)
- East Tennessee State University (3781)
-
- University of Denver (2609)
- Duquesne University (2246)
- Abilene Christian University (1048)
- Stephen F. Austin State University (675)
- Coastal Carolina University (202)
- Xavier University of Louisiana (153)
- University of Health Sciences and Pharmacy in St. Louis (3)
- University of Memphis (2)
- Georgia Southern University (1)
- Keyword
-
- Morgridge College of Education (709)
- College of Arts Humanities and Social Sciences (657)
- Education (606)
- Daniel Felix Ritchie School of Engineering and Computer Science (397)
- College of Natural Science and Mathematics (259)
-
- Gender (212)
- Higher education (205)
- School administration (200)
- Josef Korbel School of International Studies (197)
- Leadership (188)
- Teaching and Learning Sciences (167)
- Psychology (164)
- Identity (151)
- Retention (150)
- Communication (143)
- Phenomenology (140)
- Women (135)
- Joint Ph.D. Program in Study of Religion (132)
- Race (127)
- Depression (124)
- Curriculum and Instruction (121)
- Mathematics (121)
- Technology (120)
- Machine learning (118)
- Stress (117)
- Simulation (114)
- Higher Education (110)
- Performance (109)
- Anthropology (105)
- Religion (104)
- Publication Year
- File Type
Articles 8521 - 8550 of 35655
Full-Text Articles in Entire DC Network
Novel Application Of Melt Extrusion And Additive Manufacturing On Developing Diverse Dosages, Jiaxiang Zhang
Novel Application Of Melt Extrusion And Additive Manufacturing On Developing Diverse Dosages, Jiaxiang Zhang
Electronic Theses and Dissertations
New drug product development is a time consuming and costly process. One of the significant challenges is the poor aqueous solubility of many active pharmaceutical ingredients (APIs). Among those techniques, hot-melt extrusion(HME) is optimal for pharmaceutical solid dispersion development because of it free of using an organic solvent, easy scale up, and suitable for continuous processing with ensured optimal quality control.
Comparative Effectiveness And Safety Of Non-Vitamin K Antagonists Oral Anticoagulants And Warfarin In Elderly Patients With Non-Valvular Atrial Fibrillation And Diabetes, Siddhi Korgaonkar
Comparative Effectiveness And Safety Of Non-Vitamin K Antagonists Oral Anticoagulants And Warfarin In Elderly Patients With Non-Valvular Atrial Fibrillation And Diabetes, Siddhi Korgaonkar
Electronic Theses and Dissertations
Results: The matched sample consisted of 4578 patients (2291 in each group). NOACs were found to significantly reduce the risk of stroke/SE compared to warfarin (Hazard Ratio (HR): 0.373, 95% confidence interval (CI): 0.247 - 0.564, p<0.001); but, no significant difference was seen between NOACs and warfarin in terms of reducing the risk of MI (HR: 0.864, CI: 0.594 – 1.257, p=0.446). NOACs were found to significantly reduce the risk of ICH (HR: 0.500, CI: 0.300 – 0.834, p=0.008) and OB (HR: 0.608, CI: 0.424 – 0.870, p=0.007); but no difference was seen in the risk of MGB (HR: 0.862, CI: 0.640 – 1.160, p=0.326) between NOACs and warfarin. NOACs were also found to reduce the risk of all-cause mortality (HR: 0.783, CI:0.656 – 0.873, p=0.007). The composite of effectiveness and safety outcomes, and all-cause mortality was statistically significant proving superior overall effectiveness and safety of NOAC therapy to warfarin therapy in terms of risk reduction (HR:0.685, CI:0.587 – 0.801, p<0.001).
Validation Of A Brief Screening Instrument For Psychopathology In Adults, Adam Sattler
Validation Of A Brief Screening Instrument For Psychopathology In Adults, Adam Sattler
Electronic Theses and Dissertations
Structured diagnostic interviews are generally considered to be the gold standard method of assessing mental health conditions; however clinicians rarely use such techniques in clinical practice. A major factor contributing to the infrequent use of structured interviews is the amount of time required for administration and interpretation. As such there is a need to develop assessment instruments that balance the objectivity and structure of evidence-based assessment techniques against personnel time and cost. To address this need the current study sought to validate a brief screening instrument for assessing 9 commental health conditions using a well-researched structured clinical interview to establish …
E-Cigarettes And Conventional Cigarettes: Perceived Risks And Benefits Among College Students, Evi Addoh
E-Cigarettes And Conventional Cigarettes: Perceived Risks And Benefits Among College Students, Evi Addoh
Electronic Theses and Dissertations
ABSTRACT Background: Accompanying the decline in cigarette smoking rates has been a rise in prevalence of electronic cigarette (e-cigarette) use. The ongoing investigations on the health impact of e-cigarettes have been accompanied by mixed messages and a lack of consensus which may lead college students to rely on their own perceptions of risk and benefits in deciding whether to use e-cigarettes. Conclusion: Considering the significant association of perceived risks and benefits with e-cigarette and cigarette use this study yields some findings that show the importance of appropriately addressing perceptions. It is paramount to keep the public updated on pertinent research …
Valuation Of Mentorship In Pharmacy Education And The Impact Of Perceived Personal Relevance, Ashley Stubblefield Crumby
Valuation Of Mentorship In Pharmacy Education And The Impact Of Perceived Personal Relevance, Ashley Stubblefield Crumby
Electronic Theses and Dissertations
Mentorship is an important component of personal and professional development for student pharmacists. This research measured the value of mentorship in this population examined potential influencing factors and the likelihood to participate in a mentoring relationship and identified preferences for the mentoring relationship. Data collection involved survey self-report of student pharmacists (P1-P4) at four participating universities. An adapted 29-item Mentoring Functions Scale (MFS) was used to measure value with functions divided into career and psychosocial categories. The highest ranked mentoring functions were psychosocial with an average score of 9 or greater on the 10-point scale. Perceived personal relevance measured using …
Evaluating The Effects Of Water Influx On The Mississippi Sound: Current Vs. Historical Relationships, Jarett Lee Bell
Evaluating The Effects Of Water Influx On The Mississippi Sound: Current Vs. Historical Relationships, Jarett Lee Bell
Electronic Theses and Dissertations
This research investigated the influence of the opening of the Bonnet Carre Spillway and other fresh water inputs on the Mississippi Sound. The Bonnet Carre Spillway was completed in 1931 and was constructed to protect New Orleans whenever the Mississippi River is at flood stage. The spillway drains into Lake Pontchartrain a brackish-water lagoon north of New Orleans which then drains into Lake Borgne and subsequently into the Mississippi Sound. The inflow of water from the spillway changes the water chemistry of all receiving water bodies and impacts the waters of the Mississippi Gulf Coast. We collected in-situ temperature specific …
Alaska And The Arctic In The U.S. Imaginary, Ryan Charlton
Alaska And The Arctic In The U.S. Imaginary, Ryan Charlton
Electronic Theses and Dissertations
Popular narratives of Alaska have long relied on the region’s mythical status as the “last frontier” a perception which enfolds Alaska into a continental narrative of U.S. expansion. This frontier image has foreclosed our ability to appreciate the profound instability which the 1867 Alaska Purchase brought into U.S. national discourse at a time when Americans were eager to adopt a fixed national identity. In the three decades following the purchase Alaska would resist incorporation into the national imaginary challenging the coherence of U.S. national identity and calling into question foundational myths of the United States as a continental and agrarian …
A Brief Acceptance And Commitment Therapy Based Intervention For Distressed Graduate Students, Emily Hannah Katt Jacobson
A Brief Acceptance And Commitment Therapy Based Intervention For Distressed Graduate Students, Emily Hannah Katt Jacobson
Electronic Theses and Dissertations
Graduate students report to experience distress at high rates. Research suggests that self-care behaviors such as sleep exercise and mindfulness practice can helpful for mental health and wellbeing. The current study examined the effectiveness of a brief Acceptance and Commitment Therapy (ACT) based intervention on increasing self-care behaviors in distressed graduate students at the University of Mississippi (N=7). The intervention was delivered in three 60-minute individual sessions. The effects of the intervention were examined using a concurrent multiple baseline across participants design. Results indicated that five out of seven participants shoincreases in self-reported self-care behaviors after the start of the …
A First-Year Teacher’S Implementation Of Short-Cycle Formative Assessment Through The Use Of A Classroom Response System And Flexible Grouping, Adrienne Irving Dumas
A First-Year Teacher’S Implementation Of Short-Cycle Formative Assessment Through The Use Of A Classroom Response System And Flexible Grouping, Adrienne Irving Dumas
Electronic Theses and Dissertations
As teachers we are tasked with ensuring that our students are equipped with the skills necessary to not only perform with proficiency on local state and national assessments but also to provide our students with opportunities to develop confidence and competence as learners of mathematics through meaningful challenging and worthwhile activities. As such many teachers have turned to technology and cooperative groups as staples in the classroom. The purpose of this study was to understand how one first-year teacher implemented what she was taught in her undergraduate coursework in teaching two specific units of instruction in two sections of high …
Measures Of Music Teacher Effectiveness In Three Early Career Levels, Alicia L. Canterbury
Measures Of Music Teacher Effectiveness In Three Early Career Levels, Alicia L. Canterbury
Electronic Theses and Dissertations
Corroborative findings across instructional targets rehearsal frames and the summative evaluations indicated a general lack of specificity across all levels which improved somewhat during student teaching and peer teaching. Unidentified targets and nonspecific positive feedback were observed less frequently in student teaching and novice teaching. No growth was found across levels in specific positive and negative feedback. Directives were the most frequently observed teacher verbal category in selected rehearsal frames and information and demonstrations were consistently the highest ranked items across all levels in the summative evaluation. However instructional directive scores were inconsistent. Results indicate that new teachers of all …
Description And Alleviation Of The Stress Response In Atlantic Sharpnose Sharks (Rhizoprionodon Terraenovae), White-Spotted Bamboo Sharks (Chiloscyllium Plagiosum), And Golden Shiners (Notemigonus Crysoleucas), Lauren Nicole Fuller
Electronic Theses and Dissertations
Sharks are an essential component of many marine ecosystems; however they have experienced population declines mainly attributed to overfishing and capture of sharks as bycatch. Despite sharks often being released when captured as bycatch the act of capture can result in a stress response which may cause severe physiological perturbations. Studies have investigated the physiological impacts of capture stress on elasmobranchs but most have primarily focused on the secondary stress response. I conducted a series of studies to further describe the primary stress response through quantification of adrenocorticotropic hormone (ACTH) while also investigating methods such as sedation and limiting air …
Pharmacy Value-Based Incentive Programs: An Evaluation Of Health Plan Strategies, Pharmacist Attitudes, And Financial Impact On Retail Stores, Tristen H. Jackson
Pharmacy Value-Based Incentive Programs: An Evaluation Of Health Plan Strategies, Pharmacist Attitudes, And Financial Impact On Retail Stores, Tristen H. Jackson
Electronic Theses and Dissertations
Since the Affordable Care Act (ACA) in 2012 health plans serving Medicare beneficiaries have begun receiving sizeable incentives (>$1B) for demonstrating high ratings to quality performance scores in CMS’s Medicare star ratings program. Several of the quality measures can be directly impacted by retail pharmacists (e.g. medication adherence measures) resulting in health plans implementing programs designed to incentive retail pharmacies to work toward improving their own performance related to quality measures. While awareness of these value-based incentive (VBI) programs is growing there is still a significant lack of research which elucidates the nature of these programs and the potential …
Doing Hard Things In The Context Of Values: Values Intervention As An Establishing Operation For Approach Behavior In The Presence Of Aversive Stimuli, Emmie Hebert
Electronic Theses and Dissertations
Aversive control is an umbrella term for behavioral contingencies influenced by the removal or avoidance of aversive stimuli. When individuals are engaging in behavior that is under aversive control the behavior becomes relatively insensitive to changes in the environment outside of trying to escape or avoid the aversive stimulation. Teaching individuals to increase behavioral and psychological flexibility around potentially aversive stimuli is a goal of a therapeutic perspective called Acceptance and Commitment Therapy (ACT). ACT therapists and trainers use values to motivate their clients to engage in meaningful behaviors despite ever-changing and often aversive contexts. The aim of the current …
To Sink Our National Character: Slavery And National Character In The U.S. House Of Representatives, 1789-1820, Jessica Johnson
To Sink Our National Character: Slavery And National Character In The U.S. House Of Representatives, 1789-1820, Jessica Johnson
Electronic Theses and Dissertations
In 1790 1804 and 1819 the U.S. House of Representatives debated measures intended to restrict slavery and the transatlantic slave trade. During these three debates slaveholding representatives primarily from the Lower South attempted to call into question the general government’s right to discuss and legislate on slavery contending that except for in a few specific instances outlined in the Constitution slavery was purely a state matter not a national one. Their opponents employed a variety of tactics to counter this idea. One particularly effective approach was an expression of concern for the impact of slavery and the slave trade on …
How Ghost Stories Shape The State Of Mississippi And The People, Ana Lauren Martinez
How Ghost Stories Shape The State Of Mississippi And The People, Ana Lauren Martinez
Electronic Theses and Dissertations
Many people chose to brush off the stories and when asked about them they would skip around the story to talk about the history of a place. Those who embraced the stories were not only knowledgable about the stories but also the history. They tended to give both sides with equal enthusiasm and seriousness. Over the years Mississippians have learned about their neighbors through the stories that they told around the campfire or at sleepovers. These stories have been passed down from one generation to the next and have a way of not only identifying a place but also a …
Beta Invariant And Variations Of Chain Theorems For Matroids, Sooyeon Lee
Beta Invariant And Variations Of Chain Theorems For Matroids, Sooyeon Lee
Electronic Theses and Dissertations
The beta invariant of a matroid was introduced by Crapo in 1967. We first find the lower bound of the beta invariant of 3-connected matroids with rank r and the matroids which attain the lower bound. Second we characterize the matroids with beta invariant 5 and 6. For binary matroids we characterize matroids with beta invariant 7. These results extend earlier work of Oxley. Lastly we partially answer an open question of chromatic uniqueness of wheels and prove a splitting formula for the beta invariant of generalized parallel connection of two matroids. Tutte's Wheel-and-Whirl theorem and Seymour's Splitter theorem give …
Mandated Representation: The Effect Of Legislative Gender Quotas On Attitudes Toward Gender Equality, Rustin Suray
Mandated Representation: The Effect Of Legislative Gender Quotas On Attitudes Toward Gender Equality, Rustin Suray
Electronic Theses and Dissertations
Do gender quotas actually change attitudes toward gender equality? Research suggests that quotas influence gender norms but very little work has looked at whether individual attitudes themselves change when gender quotas are enacted. This paper attempts to fill this void by studying the relationship between quota implementation and gender attitudes at a cross-national level using longitudinal survey data from the World Values Survey in a two-level random intercept multi-level model. This type of model is appropriate because it does not assume that individual observations in the data are independent from one another. The individual respondents from the WVS data are …
Automation Of Data Collection From An Anechoic Chamber, Thomas S. Garner
Automation Of Data Collection From An Anechoic Chamber, Thomas S. Garner
Electronic Theses and Dissertations
This paper describes the calibration methods and the process that is used on the Ole Miss electrical engineering anechoic chamber. Furthermore the MATLAB code that operates the anechoic chamber has been updated to collect sweep data. The GUI also now includes a tab for calibration giving the user the ability to calibrate for their desired frequency range for when there is not sufficient calibration data already available.
Teaching Kids To Say "Ew!": Parent-Child Disgust Transmission, Brooklee Lightsey Tynes
Teaching Kids To Say "Ew!": Parent-Child Disgust Transmission, Brooklee Lightsey Tynes
Electronic Theses and Dissertations
Disgust is one of the six basic emotions but research suggests it is far more complex. As individuals respond to stimuli in different manners this suggests the emotion and its development may be shaped through learning principles and cultural practices (Rozin Lowery & Ebert 1994). It is imperative to understand how children’s disgust responses are shaped though observation classical and operant conditioning demonstrated by their primary caregivers. The current study examined the transmission of the emotion of disgust from primary caregivers to their children. Participants were 17 children (55.6% female) and one of their parents in Mississippi and Nebraska. The …
Emotion Regulation As A Predictor Of Pediatric Obsessive-Compulsive Symptoms, Brittany Spence Sapp
Emotion Regulation As A Predictor Of Pediatric Obsessive-Compulsive Symptoms, Brittany Spence Sapp
Electronic Theses and Dissertations
Research findings suggest that emotion regulation (ER) is a key component in the maintenance and development of psychopathology. However there is a paucity of research assessing ER and Obsessive-Compulsive (OC) symptoms particularly how ER relates to OC tendencies in children. Due to the pervasive nature of both ER difficulties and OC symptoms across major life domains (i.e. familial social academic) and the lasting impact of these problems into adulthood further research is needed to better understand this connection. The present study investigated this relation in a clinical sample of 472 youth (ages 10 – 17) who completed a packet of …
The Relationship Between Intra-Cultural Factors And Feedback Seeking Behavior In Supervision Among Counselors-In-Training In Counselor Education Programs, Sumedha Therthani
The Relationship Between Intra-Cultural Factors And Feedback Seeking Behavior In Supervision Among Counselors-In-Training In Counselor Education Programs, Sumedha Therthani
Electronic Theses and Dissertations
For this research study a cross-sectional correlational survey research design was utilized. Counselors in training both master and doctoral level currently receiving clinical supervision in counselor education programs (n=123) participated in this study. Participants were administered (a) tolerance of ambiguity scale (b) individual power distance scale (c) feedback-seeking frequency scale (d) feedback-seeking source scale and (e) feedback-seeking style scale. Six research questions were the subject of data analyses in this study. Analyses included conducting multivariate multiple regression and simple regression analyses to understand whether tolerance of ambiguity and status identity predict graduate counselors’ feedback-seeking (a) style (b) source and (c) …
Limited Negotiation In Embedded Ultimatum Games, Alexandros Vasios Sivvopoulos
Limited Negotiation In Embedded Ultimatum Games, Alexandros Vasios Sivvopoulos
Electronic Theses and Dissertations
This study expands on previous work done on signaling/screening take-it-or-leave-it asymmetric information games where excess disputes occur. Two players engage in an embedded ultimatum game in a stylized legal framework of plaintiff versus defendant. The plaintiff has either a low or a high claim on the uninformed defendant. There is a computerized version of the embedded ultimatum game to test replicability of literature results. Two novel variations are introduced. In the first variation multiple sequential offers can be made by the proposer during a single period of the embedded game and in the second real time offers and counteroffers can …
Improving Random Forests By Feature Dependence Analysis, Silu Zhang
Improving Random Forests By Feature Dependence Analysis, Silu Zhang
Electronic Theses and Dissertations
Random forests (RFs) have been widely used for supervised learning tasks because of their high prediction accuracy good model interpretability and fast training process. However they are not able to learn from local structures as convolutional neural networks (CNNs) do when there exists high dependency among features. They also cannot utilize features that are jointly dependent on the label but marginally independent of it. In this dissertation we present two approaches to address these two problems respectively by dependence analysis. First a local feature sampling (LFS) approach is proposed to learn and use the locality information of features to group …
Comparative Assessment Of Safety And Quality Of Tinospora Species-Tinospora Crispa And Tinospora Sinensis, Abidah Parveen
Comparative Assessment Of Safety And Quality Of Tinospora Species-Tinospora Crispa And Tinospora Sinensis, Abidah Parveen
Electronic Theses and Dissertations
Tinospora crispa Miers ex Hook.f. & Thomson and Tinospora sinensis (Lour.) Merr. (Menispermaceae) are two species that have morphological similarities which makes distinction between the two of critical importance because T. crispa has been reported to cause hepatotoxicity. Comparative morpho-anatomy of the leaves and stems of Tinospora species indigenous to south and southeast Asia was undertaken to elaborate their distinguishing pharmacognostic features. Chemical characterization of the secondary metabolites of the two species may aid in elucidating their chemical diversity and hence help to resolve safety and quality issues. Phytochemical investigation of the stems led to the isolation of nineteen compounds …
African American Students In Physical Therapy: Enhancing Diversity, Kimberly Renee Willis
African American Students In Physical Therapy: Enhancing Diversity, Kimberly Renee Willis
Electronic Theses and Dissertations
African Americans are motivated by early exposure to the profession and future expectations for their personal career path including stability work-life balance and helping others. The elimination of barriers such as finances lack of support and cultural microaggressions influences their career path. Following statistical analysis of admissions data conclusions were made that the current admissions criteria does not successfully predict first year success for any students including African American students. Lastly African American physical therapy graduates from UMMC reported excitement upon admission concerns over quotas lack of African American faculty students and physical therapists and the presence of microaggressions while …
Role Of Cardiolipin Remodeling In The Malignant Progression Of Breast Cancer, Jawaher H. Alkhamisy
Role Of Cardiolipin Remodeling In The Malignant Progression Of Breast Cancer, Jawaher H. Alkhamisy
Electronic Theses and Dissertations
In spite of the current advances in both radiotherapy and surgical techniques as well as molecularly targeted therapies, over 90 percent of cancer mortality rate is due to metastases. Considering the pivotal role of metabolism in cellular physiology, there is no doubt that metabolic alterations are critical for metastatic progression. Cardiolipin (CL), the signature phospholipid of mitochondria, is linked to a variety of vital mitochondrial processes, like oxidative phosphorylation. Cardiolipin is a unique dimeric phospholipid which contains four fatty acyl chains. Moreover, the CL remodeling process is believed to be responsible for generation of immature CL species that contribute to …
Youth Screening Protocol For General Psychopathology, Steven Bishop
Youth Screening Protocol For General Psychopathology, Steven Bishop
Electronic Theses and Dissertations
There is a high prevalence rate of psychopathology among US youth, with at least one in four youth meeting clinical criteria for a mental health condition. Those youths who experience psychopathology tend to demonstrate greater functional impairments and have more adverse outcomes compared to youth who do not have these frequently occurring conditions. It is unfortunate that many of these conditions, along with their deleterious effects, are poorly identified in pediatric settings despite the availability of screening instruments. Most screening instruments, however, assess for domain-specific areas of psychopathology only, and can require substantial time to administer and interpret within the …
Essays On Money And Labor, Kwabena Okyere Boateng
Essays On Money And Labor, Kwabena Okyere Boateng
Electronic Theses and Dissertations
The price-specie-flow mechanism (PSFM) is a theory of the adjustment of the balance of trade and gold flows as a result of deviations in relative prices across countries under a gold standard. The PSFM is central to quantity-theoretic discussions of economic fluctuations under a gold standard as well as analysis of whether central banks follo``the rules of the game'' of the gold standard. In short, the PSFM is the standard working assumption when it comes to gold standard adjustment. However, at least since Adam Smith there has been an alternative to the PSFM that has come to be known as …
Factors Related To Obsessive-Compulsive Symptoms: Understanding The Contribution Of Disgust, Contamination Fear And Emotion Regulation, Alexandra Gilbert
Factors Related To Obsessive-Compulsive Symptoms: Understanding The Contribution Of Disgust, Contamination Fear And Emotion Regulation, Alexandra Gilbert
Electronic Theses and Dissertations
The current study included 149 students from the University of Mississippi as apart of an archival dataset from a larger lab study. Results from the primary analyses indicate that all variables of interest (i.e. contamination fear, disgust sensitivity, and emotion regulation) were significantly correlated with OC symptoms. However, despite disgust’s associations with OC symptoms, results from regression analysis suggest that neither general disgust nor individual domains of disgust were predictive of contamination-based OC symptoms above and beyond contamination fear. Results from the hierarchical regression analysis emphasize the prominent role that contamination fear has on contamination-based OC symptoms. Further, sex differences …
A Study To Regioselectively Access Fluorinated Triazoles And Isoxazoles, Sweta Adhikari
A Study To Regioselectively Access Fluorinated Triazoles And Isoxazoles, Sweta Adhikari
Electronic Theses and Dissertations
The objective of the thesis is to develop regioselective methods for mono-fluorination of disubstituted triazoles, both 1,4- and 1,5-regioisomer, and isoxazoles. These strategies focus on one-pot direct access to final mono-fluorinated triazoles and isoxazoles. Eventually, these fluorinated substrates will be screened against various biological targets. Similarly, the optimization study of a regioselective method to generate 5-fluoro-1,4-disubstituted triazole was conducted. This reaction also utilized 1,3-dipolar cycloaddition to synthesize fluorinated triazole. However, difluoroalkene was used as a synthetic equivalent of fluoroalkyne for this method. This resulted into the inversion of polarity affording a different regioisomer. Here, fluoronitroalkene was identified as a synthetic …