Digital Commons Network^™

Therapeutic Potential Of Withaferin A Against Non-Small Cell Lung Cancer., Al Hassan Kyakulaga

Electronic Theses and Dissertations

Lung cancer is the leading cause of cancer-related deaths worldwide and in the United States. Despite recent advancements in treatment approaches, chemoresistance and metastasis remain a major therapeutic challenge. Withaferin A (WFA), a plant-derived compound has recently emerged as a promising antitumor agent. In the present study, we explored the therapeutic potential of WFA against advanced NSCLC. Briefly, WFA was evaluated for its efficacy, toxicity and pharmacokinetic properties against advanced NSCLC using in vitro and in vivo models. Two human NSCLC cell lines, H1299 and A549 were used in cell culture to determine the anticancer properties of WFA. Repeat dose …

Laser Spectroscopy Investigations Of Jet-Cooled Metal-Containing Free Radicals., Anam Chandra Paul

Electronic Theses and Dissertations

Metal-containing free radicals are important intermediates in metal-surface reactions and the interactions between metals and organic molecules. Among metal-containing free radicals, monovalent derivatives of alkaline earth metals have been extensively investigated by using spectroscopic techniques in a gas phase, mainly in Broida ovens or under supersonic-jet-cooled conditions. In the present study, the results of performed spectroscopic investigations of both metal-containing monoalkoxides (CaOR) and metal oxides (MO) radicals have been reported. Laser-induced fluorescence (LIF) and dispersed fluorescence (DF) spectra of the electronic transition of the calcium CaOR radicals have been obtained under jet-cooled conditions. Complete active space self-consistent field (CASSCF) and …

A Recombinant Cholera Toxin B Subunit Variant (Ctb-Kdel) Exhibits Unique Colon Mucosal Healing Effects That Have Therapeutic Implications For Inflammatory Bowel Disease., Joshua Mark Royal

Electronic Theses and Dissertations

This dissertation uncovers the mechanism and explores the utility of a recombinant cholera toxin B subunit (CTB) variant containing a KDEL endoplasmic reticulum (ER) retention motif (CTB-KDEL) as a drug candidate for the treatment of inflammatory bowel disease (IBD). CTB is a mucosal immunomodulatory protein that induces robust mucosal and systemic antibody responses. This well-known biological activity has been exploited in cholera prevention (as a component of Dukoral® vaccine) and vaccine development for decades. On the other hand, several studies have investigated CTB’s immunotherapeutic potential in the treatment of inflammatory diseases such as Crohn’s disease and asthma. Here, we reveal …

The Identification Of Long Non-Coding Rna Zfas1 Through An Exploratory Rna-Sequencing Analysis And Its Association With Epithelial-To-Mesenchymal Transition In Colon Cancer Adenocarcinoma., Stephen J. O'Brien

Electronic Theses and Dissertations

Colorectal adenocarcinoma is the fourth most common cancer diagnosed worldwide and is a significant cause of morbidity and mortality. This dissertation performed an exploratory RNA-sequencing analysis comparing gene expression between colon adenocarcinoma tissue and paired normal colon epithelium. After identification of a number of lncRNAs that were increased in expression in colon adenocarcinoma compared to normal colon epithelium, we aimed to validate the expression and investigate their function in vitro. Specifically, we focused on the lncRNA ZFAS1 and its association with epithelial-to-mesenchymal transition. These studies found the following: 1. Seven candidate lncRNAs were identified from the exploratory RNA-sequencing analysis to …

Disentangling The Negativity Bias: 7-9-Month-Old Crawling And Non-Crawling Infants' Responses To Fearful And Angry Expressions., Katherine C. Dixon

Electronic Theses and Dissertations

Understanding the origins of the negativity bias in infancy and how it develops is important for building a complete understanding of emotion perception. The goal of the present study was to 1) examine attentional biases for emotional expressions in infants between 7-9 months of age, specifically the bias for fearful and angry expressions, 2) examine how the onset of crawling is related to these biases and what that suggests about the mechanism underlying emotion preference in infants, and 3) examine how infant expression production differs when viewing different facial expressions. Infant attention biases to fearful, angry, happy, and neutral facial …

Simulation And Optimization Of A Multi-Agent System On Physical Internet Enabled Interconnected Urban Logistics., Long Zheng

Electronic Theses and Dissertations

An urban logistics system is composed of multiple agents, e.g., shippers, carriers, and distribution centers, etc., and multi-modal networks. The structure of Physical Internet (PI) transportation network is different from current logistics practices, and simulation can effectively model a series of PI-approach scenarios. In addition to the baseline model, three more scenarios are enacted based on different characteristics: shared trucks, shared hubs, and shared flows with other less-than-truckload shipments passing through the urban area. Five performance measures, i.e., truck distance per container, mean truck time per container, lead time, CO₂ emissions, and transport mean fill rate, are included in …

Denkyem (Crocodile): Identity Development And Negotiation Among Ghanaian-American Millennials., Jakia Marie

Electronic Theses and Dissertations

Ghanaian immigrants and second-generation Ghanaian-American Millennials are largely ignored in scholarship. Using qualitative methods, this study explored the experiences of Ghanaian-American Millennials who are first, 1.5, and second-generations with the purpose of understanding how they create, negotiate, and re-create identities. Twenty-one individuals were interviewed using a phenomenological approach. The main findings suggest that even though the sample populations were of different immigrant generations, they have some similar experiences, which demonstrates the value in exploring age instead of solely immigrant generation. The findings also suggest that there are a number of complex layers that are involved in identity development and negotiation …

Addressing The Problem Of Sterile Drug Injecting Supply Acquisition For People Who Inject Drugs., Barbra Ann Cave

Electronic Theses and Dissertations

This dissertation contains five chapters, including three manuscripts, covering harm reduction and some of the challenges people who inject drugs (PWID) face in their effort to reduce the risk of injection drug-related harms through sterile injecting supply acquisition and use. Chapter One discusses some background related to PWID and provides an overview of the issues addressed in this dissertation. Chapter Two includes a literature review covering the harm reduction concept, important aspects of syringe exchange programs as a harm reduction tool, and the social determinants of health model as a potential tool for future research. Chapter Three is a two-phase …

Campus Recreation Inclusion For People With Disabilities: A Qualitative Investigation Of Current Inclusive Practices., Tyler C. Spencer

Electronic Theses and Dissertations

This study investigated the current practices of campus recreation professionals to create inclusive campus recreation programs, services, and facilities. The researcher identified twelve campus recreation programs known by their peers and the industry to be at the forefront of providing inclusion efforts to people with disabilities. Through in-depth discussions with campus recreation practitioners at the twelve identified institutions, the investigation elicited a variety of interesting results. Utilizing the frameworks of Critical Disability Theory and Universal Design, this investigation identified how campus recreation practitioners perceive the inclusiveness of their campus recreation departments and how the campus recreation practitioners developed their inclusive …

The Relationship Between Employee Engagement And Work Performance For Individuals Working In Active Asset Management: Examining The Moderate Effect Of Age, Gender, And Job Function., Elizabeth Aubrey Brenner

Electronic Theses and Dissertations

The construct of employee engagement and its relationship to desirable organizational outcomes has received a great deal of attention within Human Resource Development (HRD) literature. However, little research has examined the influence of employee engagement on work performance in the active asset management industry, and no academic study has explored employee engagement in the active asset management industry using the lens of HRD. This study examined the relationship between employee engagement and work performance, and the moderating effect of age, gender, and job function on the relationship between employee engagement and work performance, for individuals employed within active asset management. …

Gc×Gc-Ms And Parallel 2dlc-Ms Based Untargeted Metabolomics., Md Aminul Islam Prodhan

Electronic Theses and Dissertations

Untargeted metabolomics aims to analyze as many metabolites as possible in a biological system. Due to the vast complexity of the metabolome, bioanalytical platforms have been developed for untargeted metabolomics. While comprehensive two-dimensional gas chromatography mass spectrometry (GC×GC-MS) has been used in different scientific fields, its use in untargeted metabolomics is limited due to several challenges, such as complicated data analysis and limited accuracy of metabolite identification. Two-dimensional liquid chromatography mass spectrometry (2DLC-MS) has also been employed in untargeted metabolomics, but with limited metabolite coverage. This dissertation describes the efforts in developing new data analysis algorithms to improve the accuracy …

Do Lgbtq-Identified, Postsecondary Writing Instructors Come Out In Their Classrooms?, Michael Baumann

Electronic Theses and Dissertations

My dissertation investigates how and why LGBTQ-identified, postsecondary writing instructors perform intersectional identities in their classrooms. Scholars in the field of rhetoric and composition have examined these critical questions as early as 1974 and several times since. However, oppressive, regressive sexual politics; a maelstrom of contemporary public confessions made possible and prolific through new media; and an increasingly intersectional landscape of queer people all provide exigency to update our coming out conversation. This dissertation is the analytical writeup of a national study that I conducted in 2018. I surveyed approximately 100 LGBTQ-identified postsecondary writing instructors in the United States and …

Police Stress, Depression, And Substance Use Among Police Officers: A General Strain Perspective., Kyra Nicole Fritz

Electronic Theses and Dissertations

This dissertation examines the utility of general strain theory in explaining substance use as a form of coping among a sample of police officers in a Midwestern, metropolitan city. The dissertation is comprised of five chapters, including the introduction, literature review, method, results, and discussion. Chapter one describes the stressful nature of a career in law enforcement, concentrating on the adverse consequences of prolonged stress, including depression and substance use. Chapter one also examines strain, depression, and substance use among police officers using a general strain perspective, highlighting the limitations of existing empirical studies. Chapter two details the theoretical premise …

Understanding Worry And Mindfulness Through Psycholinguistics., Elena Maria Clara Geronimi Bortoleto

Electronic Theses and Dissertations

Our understanding of psychological constructs through language has increased over the last few decades. However, only a few studies have explored linguistic features associated with worry and mindfulness. This is the first study using linguistics to investigate features of worry models associated with worry and mindfulness concomitantly. The current study reviews literatures regarding worry and mindfulness emotional, physiological, and cognitive features, including language. Next, the current study tested the hypotheses that excessive worry would be negatively correlated with present tense and positively correlated with number of words, number of questions, anxiety related words, and negative emotion words, while mindfulness would …

Understanding Object Motion Encoding In The Mammalian Retina., Victor Julian Depiero

Electronic Theses and Dissertations

Phototransduction, transmission of visual information down the optic nerve incurs delays on the order of 50 – 100ms. This implies that the neuronal representation of a moving object should lag behind the object’s actual position. However, studies have demonstrated that the visual system compensates for neuronal delays using a predictive mechanism called phase advancing, which shifts the population response toward the leading edge of a moving object’s retinal image. To understand how this compensation is achieved in the retina, I investigated cellular and synaptic mechanisms that drive phase advancing. I used three approaches, each testing phase advancing at a …

Automatic Exposure Control During Computed Tomography Scans Of The Head: Effects On Dose And Image Quality, Stephen D. Osborne

Electronic Theses and Dissertations

Automatic exposure control (AEC) is effective at reducing potentially harmful radiation doses without sacrificing image quality for many types of computed tomography (CT) scans. However, there is a need for more information regarding the use of AEC for CT head scans. This study was conducted at Johnson County Community Hospital in Mountain City, TN. Preexisting adult CT head scans (n)60 were randomly selected to form 2 stratified samples, (n)30 each. One sample used a standard protocol, and the other used a protocol with a mA-modulated AEC system, Siemens CARE Dose 4D. Causal-comparative analyses were conducted, and …

Influence Of Competitive Sports On Disordered Eating Behaviors In Young Female Athletes, Jill Bernstorf

Electronic Theses and Dissertations

The field of treating and learning about eating disorders in athletes is a growing field that continues to flourish as more knowledge is acquired. The purpose of this study is to examine the influence that length of time in the sport, age at which an individual starts a competitive sport, level of competitiveness, and type of sport (leanness vs. non-leanness focused) has on disordered eating behaviors. The participants were college students who were involved in at least one competitive sport in their life. They completed the EAT-26 questionnaire as well as a basic questionnaire. There was not enough data collected …

Admission Criteria: A Focus On Using The Interview, Vanessa Jones

Electronic Theses and Dissertations

The growing number of candidates for allied health programs and the continued quest for identification of ideal candidates increases the pressure for allied health programs to continually improve their selection process. Despite past and recent research and the significant amount of literature on admission criteria for selective allied health programs, there is limited research on faculty perceptions of the interview as part of the admission criteria.

For this study, interviews were conducted with fifteen allied health faculty members who teach in a program with selective admissions. The interviews consisted of seven open-ended questions and were audio-recorded, then transcribed through Temi.com. …

Stories Of Color: An Exploration Of Storytelling And Racial Microaggression, Tama Lunceford

Electronic Theses and Dissertations

This study examines experiences of racial microaggressions as related to an audience through the art of Storytelling. Integrating Performance Ethnography and Critical Race Theory, it examines how storytelling may serve to illuminate the concept of racial microaggressions. After examining the current body of work on Racism, Storytelling and Microaggression, the author moves through the stories of experiences with racial microaggression from four individuals, gathered and performed as a storytelling event, before a live audience. The communicative management methods individuals use when talking about race and racial microaggressions are explored in presentation of the audience discussion which followed the performance. The …

Help-Seeking For Cognitive Impairment By The Patient : The Role Of Self-Compassion., Allison J. Midden

Electronic Theses and Dissertations

Older adults represent one of the fastest growing population groups with estimates predicting global growth from 617 million in 2015 to 1.6 billion in 2050. As the aged population increases, incidence of Alzheimer’s disease (AD) and other dementias will also increase. Professionals agree that early intervention is essential for therapeutic and quality of life purposes. However, many older adults wait several months or years to seek medical help after first noticing signs of cognitive impairment. The present study seeks to identify the predictors of help-seeking for cognitive impairment by an individual for him/herself and the role that self-compassion may play …

Education Abroad Participation: Predicting Participation Through High School Academic Record And Intent To Be Involved In College As Reported In The Freshman Survey (Tfs) And In The College Senior Survey (Css)., Elizabeth Karen Liebschutz-Roettger

Electronic Theses and Dissertations

Globalization is a topic of great interest in higher education yet fewer than 10% of college graduates participate in a formal study abroad program. While according to The American Council on Education [ACE] (2008) data, nearly 80% of incoming first-year students intend to go abroad, the reality is most students do not. Practitioners in Education Abroad (EA) are continually looking at ways to help increase student participation in overseas programs and opportunities. The study looks at frequencies and predictor models to help determine factors that influence student participation in study abroad. The study utilized HERI’s 2009 The Freshman Survey (TFS) …

It's A Mad World After All: The Influence Of Stoic Thought In Goya's Los Caprichos., Jennifer Anne Steward

Electronic Theses and Dissertations

This dissertation is a study of use of the principles of Stoic rhetoric and moral psychology in Goya’s print series, Los Caprichos. The relationship between Stoic thought and the technical aspects will be explored with regard to the effects used to support the visual conceptualizations. The function of the Caprichos as a book with chapters or parts relating particular modes of perception will be addressed. The technique of aquatint employed by Goya will also be explored. The predominance of geometric forms within the composition that reflect inter-personal relationships is also presented for consideration.

Laser Spectroscopy Investigations On Molecular And Free Radicals Dynamics., Hamzeh Telfah

Electronic Theses and Dissertations

Studying molecular dynamics and chemical kinetics is important to understand the chemical behavior of renewable energy sources. Laser spectroscopy techniques are powerful tools for the identification and diagnosis of such processes. In this dissertation, using our laser spectroscopy techniques, biofuels and solar energy were targeted as renewable energy sources study. We have studied the ultrafast exciton dynamics for a series of methylammonium lead bromide (CH3NH3PbBr3) nanostructures, nanocrystals (NCs, 0D), nanowires (NWs, 1D), and nanoplatelets (NPs, 2D) as a promising solar energy materials.1-2 Aided by analysis of UV−visible absorption and photoluminescence spectra, features in the transient absorption (TA) spectra are assigned …

Statistical Methods For Estimating And Testing Treatment Effect For Multiple Treatment Groups In Observational Studies., Xiaofang Yan

Electronic Theses and Dissertations

Note: Abstract would not save due to an issue with some of the characters.

Development And Characterization Of A Biopolymer Direct-Write Process For 3d Microvascular Structures Formation., Xiaoming Fan

Electronic Theses and Dissertations

Engineering of bulk tissues has been limited by the lack of nutrient and waste exchange in these tissues without an adjacent capillary network. To produce microvasculature, a scaffold must be produced that provides temporary mechanical support and stimulate endothelial cell adhesion, growth, and morphogenesis into a vessel. However, current well-established techniques for producing microvasculature, such as electrospinning, are limited since they lack both the precision to control fiber placement in three-dimensional space and the ability to create fiber networks with predefined diameters to replicate the physiological microvascular progression from arteriole to capillary to venule. Our group has developed a “Direct-write” …

Stability And Reactivity Analysis Of Single Metal And Bimetallic Nanostructures By Anodic Stripping Voltammetry., Dhruba Kumar Pattadar

Electronic Theses and Dissertations

This dissertation has two main themes. The first involves studies aimed at developing anodic stripping voltammetry (ASV) as an analytical tool to characterize metal nanoparticles (NPs), with a focus on the size and aggregate structure of single metal NPs and the composition and atomic arrangement of bimetallic NPs. The second main theme involves studies that use ASV and electrochemical surface area-to-volume (SA/V) measurements to study the unique reactivity and transformations of single metal and bimetallic NPs. The transformations involve size and composition changes in response to ozone and electrochemical potential. Reactions involve size dependent galvanic exchange and electrocatalytic activity. The …

Towards A Theory Of Human Mobility And Wall-Building: A Comparative Analysis Of Hadrian's Wall And The Iron Curtain., Timothy Heine

Electronic Theses and Dissertations

This thesis contributes a theory on human bordering practices that encompasses diverse types of borders and border experiences. In order to flesh out the factors underlying human wall-building, it is vital to first understand the mobile nature (both as an innate characteristic and adaptive strategy) of our species. A clearer appreciation of the biology of human mobility elucidates the seemingly counterintuitive process of the establishment of cultural boundaries. Such an inquiry into the available inter-disciplinary literature on the topics of human mobility and wall-building reveals much about the manner in which humans interpret and utilize space, the variety of walls …

The Genesis And Development Of Deathscapes In America -- A Story Of How Chicago And Louisville Cemeteries Demonstrate The Shifting Rationale Of Cemetery Placement During The 19th And 20th Centuries., Thomas D. Cleven

Electronic Theses and Dissertations

Today, most construction projects require a systematic site qualification based on a suitability analysis utilizing parameters such as slope, soil type, elevation, distance to open water, and distance to transportation. The proper siting determines the success of a project in terms of project stability and longevity. However, has this suitability analysis exist for one of the most significant phases of humanity – death. Historically dead bodies seem to have been placed without suitable qualification being many cemeteries have created environmental problems for the living. Hence, with which placement rationale has been used comes to mind. With a varied array of …

Perceptions Of Maxine Smith Fellows On Barriers That Contribute To The Underrepresentation Of African Americans In Faculty And Administrative Positions At The Tennessee Board Of Regents, Sidney R. Hill

Electronic Theses and Dissertations

African Americans are underrepresented in full-time faculty and administrative positions at Tennessee Board of Regents (TBR) institutions. This study examined the perceptions of 11 Maxine Smith Fellows on the underrepresentation at TBR institutions and provides recommendations that could assist in increasing representation of African Americans in full-time faculty and administrative positions.

A qualitative method was used for the study. Each participant was required to participate in a recorded SKYPE interview. The researcher transcribed the interviews and analyzed the data using coding to derive overarching themes that provided findings based upon the research questions.

Based upon the analysis of data, the …

In Search Of Work-Life Balance: Organizational And Economic Challenges Confronting Women In Banking And Management Consulting Firms In Southwest Nigeria, Oluwafisayo Ogundoro

Electronic Theses and Dissertations

Married women in the banking and management consulting firms in Nigeria encounter challenges that affect their commitment to their families while working long hours in demanding jobs. This study explores the challenges married women encounter and the impacts they have on women’s family lives, social lives, and health. I analyze primary and secondary sources to understand how organizational work culture such as long working hours, work competitiveness, and Nigeria’s unstable economy negatively affect the work-life balance of married women in banking and management consulting firms. Although participants shared the belief that their workplaces practiced “equality,” their descriptions of daily life …