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“I Have Prayed And Prayed: I Have Labored And Labored”: Ethnic Catholicism In Daviess Country Kentucky, 1850-1900., Edward A. Wilson Iii

Electronic Theses and Dissertations

This thesis examines the development of the German and Irish Catholic communities of Daviess County, Kentucky. The primary focus of the work is the church building process and the separation of Catholic ethnic communities. Although they shared the same faith, American Catholics were divided by nationalism and ethnic hostility. Already isolated in the United States, immigrant Catholics formed cultural communities that adapted their foreign identity to their new surroundings. Scholars often analyze Catholics in the United States during this period as a unified group, but this approach is flawed. Catholics developed hostilities against members of their own faith along ethnic …

Characterizing The Roles Of Neutral Ceramidase In Cisplatin-Induced Kidney Injury., Sophia M. Sears

Electronic Theses and Dissertations

Cisplatin is a commonly used chemotherapeutic agent with a dose-limiting nephrotoxicity. 30% of patients given cisplatin develop acute kidney injury (AKI). AKI increases risk of chronic kidney disease (CKD) development and mortality. Patients that don’t develop clinical AKI are still at risk for long term declines in renal function. Currently, there are no FDA approved agents to treat or prevent cisplatin-induced kidney injury (CDDP-KI). In this study, we demonstrated that neutral ceramidase (nCDase) knockout provides protection from AKI in the high-dose model of CDDP-KI. However, in the repeated low dose cisplatin (RLDC) model of injury and we found nCDase knockout …

Reaching Zero Waste: Determining The Student Perspective On Campus Food Waste., Cassie Anne Parkins

Electronic Theses and Dissertations

Food waste is an ongoing problem in the complex global food system. College campuses are in a unique position to address food waste through reducing it in their own food systems and by encouraging students to develop behaviors to reduce and divert waste from landfills. In this thesis project I seek to understand how students consider food waste and their attitudes and ideas about reducing it. To this end, I observed student behaviors and waste in University of Louisville’s all-you-care-to-eat dining hall and weighed plate waste there. I conducted informational interviews with University and Aramark employees, along with semi-structured interviews …

Charting A Course Through Confusion: Mapping Pathological Cranial Lesions In An Archaic Population From Kentucky., Austin Warren

Electronic Theses and Dissertations

Osteological observations interpreted as evidence for anemia (porotic hyperostosis and cribra orbitalia) have been used to interpret health and diet of past populations. These observations have contributed significantly to arguments that a deterioration of human health over time can be attributed to the adoption of agricultural subsistence practices and increased settlement aggregation. This study utilized a sample (n=110) from the Ward site (15Mcl11), a pre-agricultural, fisher-hunter-gatherer cemetery site dated to the Archaic Period in Kentucky, a part of the Shell Midden Archaic cultural complex. The impact of porotic alteration on differential mortality was assessed using Kaplan-Meier survival analysis. The Ward …

The Tournament And Chivalry As Represented By Chrétien De Troyes, Marie De France, And Geoffrey Chaucer., Hailey Michelle Brangers

Electronic Theses and Dissertations

It is a common belief among historians that the tournament was the ultimate expression of chivalry, as a place where knights could openly display their prowess, courtoisie, and largesse. A knight’s relationship with ladies was also crucial to measuring his chivalrousness. Despite the importance of both within chivalric knighthood, little has been done to explore their interrelation. With romance literature being the most tangible source for understanding both the tournament and a lady’s role in it, this thesis explores the relationship between the two. I begin with a brief introductory history of the tournament, establishing its war-centric foundations and touching …

.Pause., Richelle M. Dorris

Electronic Theses and Dissertations

.Pause. is a series of fifteen abstract oil paintings that represent a visual inspection of changing mental/emotional states of being as we navigate life. My subject matter consists of natural and organic forms that twist, contort, overlap, and flow. These aspects—combined with dramatic and gradual shifts in color, movement, layering and lighting—create a bizarre environment of conflict and growth as well as a space for contemplation.

This series is a mixture of stylistic directions, including abstract representation, gestural, and nonobjective work. Perception is called into question as the visual information becomes more obscure. Outside elements, such as lighting and the …

The Sound Of Adventure: Two Original Compositions That Combine Music, Sound Design, And Post-Production, Inspired By Outdoor Experiences, Jason K. Gibson

Electronic Theses and Dissertations

Composers have been inspired by nature for centuries, but writing music about nature is becoming more popular in our day. Now, under titles like “Landscape Music” and “Environmental Music,” many composers seek to embody the feeling of nature in music. What has yet to be fully developed is how electronic music and landscape music can overlap in the chamber music world. This project culminates in two original compositions, Natural Opposition (ca. six min), and Giants at Night (ca. 15 min), that seek to satisfy the requirements of both realms by combining naturally inspired music with electronic influences. The compositions themselves …

The Implementation Of Online Classroom Management Professional Development For Beginning Teachers, Kaytlynn Milliken

Electronic Theses and Dissertations

Effective classroom management practices are well known, yet the most efficient ways to teach them to beginning teachers is not. Online professional development is growing in popularity—though there are few examples of online classroom management training in the literature. The purpose of this qualitative study was to evaluate the experiences and implementation practices of beginning teachers that participated in online classroom management training as part of their new teacher induction program. The results suggest that online classroom management professional development as part of new teacher induction is a practical option. The beginning teachers were observed utilizing the classroom management strategies …

From Exclusion To Restoration: Implementation Successes And Barriers, Chris White

Electronic Theses and Dissertations

Exclusionary suspensions have been used extensively to handle student discipline and promote a perception of a safer environment in schools. However, an increasing number of school administrators have begun seeking alternative methods, such as restorative practices, in an effort to change the approach towards handling misbehaviors, conflict, and damaged relationships. This study occurred in a Grade 9 campus in northern Texas. The goal of the researcher was to better understand the challenges and successes of implementing restorative practices at the school during the 2018–2019 school year from multiple perspectives. Utilizing the principles of a program evaluation approach—deliberatively democratic evaluation—the researcher …

Teacher Competencies Related To Family Engagement: The Impact On Families, Melissa Kay Williamson

Electronic Theses and Dissertations

Although there is a large body of research that addresses the essential elements of family engagement, little information was available on the impact that a family engagement program had on teacher evaluation and familial self-efficacy. The purpose of this qualitative case study was to assess teacher competencies and family self-efficacy in a large urban district in West Texas. The research was conducted by gathering baseline data using questionnaires derived from the Measure of School, Family, and Community Partnerships survey and the 2015 Equitable Parent-School Collaboration Research Project University of Washington. In-depth interviews followed with both teachers and parents. Findings indicated …

“Pissing In The Wind”: Racially Discriminatory Economic Policies’ Impact On Today’S Banking Status, Use Of Alternative Financial Services And Health Outcomes., Gaberiel Jones Jr

Electronic Theses and Dissertations

Centuries of discriminatory policies and practices in the United States have created racially segregated, resource-poor urban communities. Differential benefits of banking and housing legislation were among the consequences of these policies as they contributed to drastic racial inequities in wealth. Today, racial differences in banking status and financial practices persist. However, a void exists in the literature exploring what alternative financial services (AFS) are used in lieu of banks by Black Americans, why those services are used, the thoughts and beliefs of Black Americans about the use of those services, the impact of bank locations on financial behavior patterns, and …

The Manipulation Of Host Transcription By The Ankh Effector Of Legionella., Juanita E. Von Dwingelo

Electronic Theses and Dissertations

Legionella pneumophila is a Gram-negative facultative intracellular bacterium that can be found dispersed throughout freshwater environments, where it primarily parasitizes amoebae and other protozoan species. Humans are an accidental host for L. pneumophila, and infection occurs upon inhalation of aerosolized water droplets that contain the bacteria. L. pneumophila is the causative agent of Legionnaires’ Disease, which is the result of intracellular proliferation within alveolar macrophages. Pathogenesis of L. pneumophila is dependent on the Dot/Icm type 4 secretion system (T4SS) apparatus, which is comprised of 27 proteins and is responsible for translocating over 330 effector proteins into the host cell. Many …

An Electrochemical Instrument For The Analysis Of Heavy Metals In Water Via Anodic Stripping Coulometry For Applications In Remote Sensing., Kelsey Lynn Kaht

Electronic Theses and Dissertations

From the high levels of arsenic in groundwater in Bangladesh to the lead contamination of drinking water in Flint, Michigan, there are incidents across the globe that highlight the need for a reliable instrument capable of monitoring heavy metals remotely and continuously in a variety of geographical locations. Typical instrumentation for water analysis, such as ICP and AAS, must be housed in a central lab and relies on an operator traveling to the collection site, obtaining a sample, and transporting it back to the lab. This analysis provides a snapshot of the water quality that is limited to the specific …

Non-Invasive Detection And Assessment Of Coronary Stenosis From Blood Mean Residence Times., Javad Hashemi

Electronic Theses and Dissertations

Coronary artery stenosis is an abnormal narrowing of a coronary artery caused by an atherosclerotic lesion that reduces lumen space. Fractional flow reserve (FFR) is the gold standard method to determine the severity of coronary stenosis based on the determination of rest and hyperemic pressure fields, but requires an invasive medical procedure. Normal FFR is 1.0 and FFR RT, to account for varying volume and flow rate of individual segments. Blood_RT was computed in 100 patients who had undergone the pressure-wire FFR procedure, and a threshold for Blood_RT was determined to assess the physiological significance of a stenosis, …

Electrochemical Determination Of Surface Area-To-Volume Ratio For Metal Nanoparticle Analysis., Jay Narayan Sharma

Electronic Theses and Dissertations

This dissertation describes an electrochemical approach for measuring the surface area-to-volume ratio (SA/V) of electrode-attached metal nanoparticles (NPs), which was used to analyze their size, aggregation state, and porosity. This dissertation further describes the effect of the metal NP electrode assembly method on the SA/V, which is related to metal NP catalytic activity and stability. Cyclic voltammetry (CV) in acid electrolyte followed by anodic stripping voltammetry (ASV) in KBr electrolyte allows the electrochemical measurement of the SA/V of electrode-attached Au nanospheres (NSs). In CV, the forward scan produces a thin surface Au₂O₃ layer on the Au NSs. …

The Effects Of Nicotine And Cigarette Smoking On Cardiac Electrophysiology., Affan B. Irfan

Electronic Theses and Dissertations

Cigarette smoking is a leading cause of preventable disease and premature death worldwide. The adverse effects of cigarette smoking, including proarrhythmia, are related to the mixture of chemicals, including nicotine (which sustains tobacco addiction). However, it remains unclear which individual tobacco smoke constituents and biological pathways mediate this increased risk. The purpose of this research was to explore the chronic effects of cigarette smoking, as well as compare the acute effects of nicotine and cigarette smoking, and the possible role of β-adrenoreceptors, on human cardiac electrophysiology. Chapter 1 is a comprehensive literature review of (a) the ex vivo and in …

Exploratory Learning Activities In The Physics Classroom: Contrasting Cases Versus A Rich Dataset., Campbell Rightmyer Bego

Electronic Theses and Dissertations

In exploratory learning, students engage in an exploration activity on a new topic prior to instruction. This inversion of the traditional tell-then-practice order has been shown to benefit learning outcomes, especially conceptual knowledge and preparation for future learning, but not always. In three studies, the current work examines whether the type of exploration activity impacts learning mechanisms and outcomes, on the topic of gravitational field in undergraduate physics classrooms. Activities using either contrasting cases (CC) or a rich dataset (RD) are compared in two instructional orders, explore-first (EF) and instruct-first (IF). Learning outcomes measured procedural knowledge, conceptual knowledge, and performance …

Therapeutic Potential Of Withaferin A Against Non-Small Cell Lung Cancer., Al Hassan Kyakulaga

Electronic Theses and Dissertations

Lung cancer is the leading cause of cancer-related deaths worldwide and in the United States. Despite recent advancements in treatment approaches, chemoresistance and metastasis remain a major therapeutic challenge. Withaferin A (WFA), a plant-derived compound has recently emerged as a promising antitumor agent. In the present study, we explored the therapeutic potential of WFA against advanced NSCLC. Briefly, WFA was evaluated for its efficacy, toxicity and pharmacokinetic properties against advanced NSCLC using in vitro and in vivo models. Two human NSCLC cell lines, H1299 and A549 were used in cell culture to determine the anticancer properties of WFA. Repeat dose …

Laser Spectroscopy Investigations Of Jet-Cooled Metal-Containing Free Radicals., Anam Chandra Paul

Electronic Theses and Dissertations

Metal-containing free radicals are important intermediates in metal-surface reactions and the interactions between metals and organic molecules. Among metal-containing free radicals, monovalent derivatives of alkaline earth metals have been extensively investigated by using spectroscopic techniques in a gas phase, mainly in Broida ovens or under supersonic-jet-cooled conditions. In the present study, the results of performed spectroscopic investigations of both metal-containing monoalkoxides (CaOR) and metal oxides (MO) radicals have been reported. Laser-induced fluorescence (LIF) and dispersed fluorescence (DF) spectra of the electronic transition of the calcium CaOR radicals have been obtained under jet-cooled conditions. Complete active space self-consistent field (CASSCF) and …

A Recombinant Cholera Toxin B Subunit Variant (Ctb-Kdel) Exhibits Unique Colon Mucosal Healing Effects That Have Therapeutic Implications For Inflammatory Bowel Disease., Joshua Mark Royal

Electronic Theses and Dissertations

This dissertation uncovers the mechanism and explores the utility of a recombinant cholera toxin B subunit (CTB) variant containing a KDEL endoplasmic reticulum (ER) retention motif (CTB-KDEL) as a drug candidate for the treatment of inflammatory bowel disease (IBD). CTB is a mucosal immunomodulatory protein that induces robust mucosal and systemic antibody responses. This well-known biological activity has been exploited in cholera prevention (as a component of Dukoral® vaccine) and vaccine development for decades. On the other hand, several studies have investigated CTB’s immunotherapeutic potential in the treatment of inflammatory diseases such as Crohn’s disease and asthma. Here, we reveal …

The Identification Of Long Non-Coding Rna Zfas1 Through An Exploratory Rna-Sequencing Analysis And Its Association With Epithelial-To-Mesenchymal Transition In Colon Cancer Adenocarcinoma., Stephen J. O'Brien

Electronic Theses and Dissertations

Colorectal adenocarcinoma is the fourth most common cancer diagnosed worldwide and is a significant cause of morbidity and mortality. This dissertation performed an exploratory RNA-sequencing analysis comparing gene expression between colon adenocarcinoma tissue and paired normal colon epithelium. After identification of a number of lncRNAs that were increased in expression in colon adenocarcinoma compared to normal colon epithelium, we aimed to validate the expression and investigate their function in vitro. Specifically, we focused on the lncRNA ZFAS1 and its association with epithelial-to-mesenchymal transition. These studies found the following: 1. Seven candidate lncRNAs were identified from the exploratory RNA-sequencing analysis to …

Disentangling The Negativity Bias: 7-9-Month-Old Crawling And Non-Crawling Infants' Responses To Fearful And Angry Expressions., Katherine C. Dixon

Electronic Theses and Dissertations

Understanding the origins of the negativity bias in infancy and how it develops is important for building a complete understanding of emotion perception. The goal of the present study was to 1) examine attentional biases for emotional expressions in infants between 7-9 months of age, specifically the bias for fearful and angry expressions, 2) examine how the onset of crawling is related to these biases and what that suggests about the mechanism underlying emotion preference in infants, and 3) examine how infant expression production differs when viewing different facial expressions. Infant attention biases to fearful, angry, happy, and neutral facial …

Simulation And Optimization Of A Multi-Agent System On Physical Internet Enabled Interconnected Urban Logistics., Long Zheng

Electronic Theses and Dissertations

An urban logistics system is composed of multiple agents, e.g., shippers, carriers, and distribution centers, etc., and multi-modal networks. The structure of Physical Internet (PI) transportation network is different from current logistics practices, and simulation can effectively model a series of PI-approach scenarios. In addition to the baseline model, three more scenarios are enacted based on different characteristics: shared trucks, shared hubs, and shared flows with other less-than-truckload shipments passing through the urban area. Five performance measures, i.e., truck distance per container, mean truck time per container, lead time, CO₂ emissions, and transport mean fill rate, are included in …

Denkyem (Crocodile): Identity Development And Negotiation Among Ghanaian-American Millennials., Jakia Marie

Electronic Theses and Dissertations

Ghanaian immigrants and second-generation Ghanaian-American Millennials are largely ignored in scholarship. Using qualitative methods, this study explored the experiences of Ghanaian-American Millennials who are first, 1.5, and second-generations with the purpose of understanding how they create, negotiate, and re-create identities. Twenty-one individuals were interviewed using a phenomenological approach. The main findings suggest that even though the sample populations were of different immigrant generations, they have some similar experiences, which demonstrates the value in exploring age instead of solely immigrant generation. The findings also suggest that there are a number of complex layers that are involved in identity development and negotiation …

Addressing The Problem Of Sterile Drug Injecting Supply Acquisition For People Who Inject Drugs., Barbra Ann Cave

Electronic Theses and Dissertations

This dissertation contains five chapters, including three manuscripts, covering harm reduction and some of the challenges people who inject drugs (PWID) face in their effort to reduce the risk of injection drug-related harms through sterile injecting supply acquisition and use. Chapter One discusses some background related to PWID and provides an overview of the issues addressed in this dissertation. Chapter Two includes a literature review covering the harm reduction concept, important aspects of syringe exchange programs as a harm reduction tool, and the social determinants of health model as a potential tool for future research. Chapter Three is a two-phase …

Campus Recreation Inclusion For People With Disabilities: A Qualitative Investigation Of Current Inclusive Practices., Tyler C. Spencer

Electronic Theses and Dissertations

This study investigated the current practices of campus recreation professionals to create inclusive campus recreation programs, services, and facilities. The researcher identified twelve campus recreation programs known by their peers and the industry to be at the forefront of providing inclusion efforts to people with disabilities. Through in-depth discussions with campus recreation practitioners at the twelve identified institutions, the investigation elicited a variety of interesting results. Utilizing the frameworks of Critical Disability Theory and Universal Design, this investigation identified how campus recreation practitioners perceive the inclusiveness of their campus recreation departments and how the campus recreation practitioners developed their inclusive …

The Relationship Between Employee Engagement And Work Performance For Individuals Working In Active Asset Management: Examining The Moderate Effect Of Age, Gender, And Job Function., Elizabeth Aubrey Brenner

Electronic Theses and Dissertations

The construct of employee engagement and its relationship to desirable organizational outcomes has received a great deal of attention within Human Resource Development (HRD) literature. However, little research has examined the influence of employee engagement on work performance in the active asset management industry, and no academic study has explored employee engagement in the active asset management industry using the lens of HRD. This study examined the relationship between employee engagement and work performance, and the moderating effect of age, gender, and job function on the relationship between employee engagement and work performance, for individuals employed within active asset management. …

Gc×Gc-Ms And Parallel 2dlc-Ms Based Untargeted Metabolomics., Md Aminul Islam Prodhan

Electronic Theses and Dissertations

Untargeted metabolomics aims to analyze as many metabolites as possible in a biological system. Due to the vast complexity of the metabolome, bioanalytical platforms have been developed for untargeted metabolomics. While comprehensive two-dimensional gas chromatography mass spectrometry (GC×GC-MS) has been used in different scientific fields, its use in untargeted metabolomics is limited due to several challenges, such as complicated data analysis and limited accuracy of metabolite identification. Two-dimensional liquid chromatography mass spectrometry (2DLC-MS) has also been employed in untargeted metabolomics, but with limited metabolite coverage. This dissertation describes the efforts in developing new data analysis algorithms to improve the accuracy …

Do Lgbtq-Identified, Postsecondary Writing Instructors Come Out In Their Classrooms?, Michael Baumann

Electronic Theses and Dissertations

My dissertation investigates how and why LGBTQ-identified, postsecondary writing instructors perform intersectional identities in their classrooms. Scholars in the field of rhetoric and composition have examined these critical questions as early as 1974 and several times since. However, oppressive, regressive sexual politics; a maelstrom of contemporary public confessions made possible and prolific through new media; and an increasingly intersectional landscape of queer people all provide exigency to update our coming out conversation. This dissertation is the analytical writeup of a national study that I conducted in 2018. I surveyed approximately 100 LGBTQ-identified postsecondary writing instructors in the United States and …

Police Stress, Depression, And Substance Use Among Police Officers: A General Strain Perspective., Kyra Nicole Fritz

Electronic Theses and Dissertations

This dissertation examines the utility of general strain theory in explaining substance use as a form of coping among a sample of police officers in a Midwestern, metropolitan city. The dissertation is comprised of five chapters, including the introduction, literature review, method, results, and discussion. Chapter one describes the stressful nature of a career in law enforcement, concentrating on the adverse consequences of prolonged stress, including depression and substance use. Chapter one also examines strain, depression, and substance use among police officers using a general strain perspective, highlighting the limitations of existing empirical studies. Chapter two details the theoretical premise …