Digital Commons Network^™

Reversible Lysine Acetylation Regulates Activity Of Human Glycine N-Acyltransferase-Like 2 (Hglyatl2): Implications For Production Of Glycine-Conjugated Signaling Molecules, Dominick P. Waluk, Filip Sucharski, Laszlo Sipos, Jerzy Silberring, Mary Hunt

Articles

Background: Lysine acetylation is a major post-translational modification of proteins.

Results: Human glycine N-acyltransferase-like 2 is regulated by acetylation/deacetylation of lysine 19.

Conclusion: Reversible lysine acetylation is important in regulating the activity and function of human glycine N-acyltransferases.

Significance: Our study links post-translational modification of proteins with the production of lipid signaling molecules, the N-acyl glycines.

Irish Culinary Manuscripts And Printed Books: A Discussion, Máirtín Mac Con Iomaire, Dorothy Cashman

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This paper provides a discussion of Irish Culinary Manuscripts and Printed Cookbooks. It covers Gaelic hospitality and aristocratic hospitality, setting the background for the Anglo-Irish households from which many manuscripts emerge. It charts the growing sources of information on Irish culinary history. It outlines Barbara Wheaton's framework for reading historic cookbooks and discusses the growing manuscript cookbook collection in the National Library of Ireland.

Light Coupling Between A Singlemode-Multimode-Singlemode (Sms) Fiber Structure And A Long Period Fiber Gating, Qiang Wu, Yuliya Semenova, Youqiao Ma, Pengfei Wang, Tuan Gao, Long Jin, Gerald Farrell

Articles

We propose a novel optical coupling technique based on evanescent field coupling between a singlemode-multimode-singlemode (SMS) fiber structure and a long period fiber grating (LPFG). By parallel placement of the two fiber sections in close proximity to each other, the excited multi-cladding modes from the SMS fiber section can be selectively coupled to the guided mode in the LPFG, and vice versa. A theoretical analysis based for such a structure is undertaken and the simulated results are verified by experiments demonstrating a maximum coupling efficiency of up to 1.66% (which could be improved to 27.5% in theory) over a broadband …

Property's Memories, Eduardo Peñalver

Articles

No abstract provided.

When Is A Difference Really Different? Learners' Discrimination Of Linguistic Contrasts In American Sign Language, Joseph Bochner, Karen Christie, Peter Hauser

Articles

Learners’ ability to recognize linguistic contrasts in American Sign Language (ASL)was investigated using a paired-comparison discrimination task. Minimal pairs containing contrasts in five linguistic categories (i.e., the formational parameters of movement, handshape, orientation, and location in ASL phonology, and a category comprised of contrasts in complex morphology) were presented in sentence contexts to a sample of 127 hearing learners at beginning and intermediate levels of proficiency and 10 Deaf native signers. Participants’ responses were analyzed to determine the relative difficulty of the linguistic categories and the effect of proficiency level on performance. The results indicated that movement contrasts were the …

Sex, Privacy And Public Health In A Casual Encounters Culture, Mary D. Fan

Articles

The regulation of sex and disease is a cultural and political flashpoint and recurring challenge that law's antiquated arsenal has been hard- pressed to effectively address. Compelling data demonstrate the need for attention—for example, one in four women aged fourteen to nineteen is infected with at least one sexually transmitted disease ("STD"); managing STDs costs an estimated $15.9 billion annually; and syphilis, once near eradication, is on the rise again, as are the rates of HIV diagnosis among people aged fifteen to twenty-four. Public health officials on the front lines have called for paradigm changes to tackle the enormous challenge. …

Digital Books And The Salvation Of Academic Publishing., Roger Cross

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Digitization was not, nor ever will be, the solution to problems faced by Academic Libraries. Digitization cannot be downplayed, however no amount of digitization will ever address the systemic issues that lie at the heart of academic library’s difficulties. Digitization is merely a means of data delivery and as such does not address foundational defects within the academic system. The true salvation through digitization will not be found in libraries, but in commercial publisher’s bottom line.

Performance Of Coiled Tube Ultraviolet Reactors To Inactivate Escherichia Coli W1485 And Bacillus Cereus Endospores In Raw Cow Milk And Commercially Processed Skimmed Cow Milk, Ruplal Choudhary, Srinivasaro Bandla, Dennis G. Watson, John Haddock, Amer Abughazaleh, Bhaskar Battacharya

Articles

Two coiled tube reactors were designed to investigate the influence of Reynolds number (Re) and diameter of fluid carrying tube on UV-C inactivation of Escherichia coli W1485 and Bacillus cereus endospores in raw cow milk (RCM) and skimmed cow milk (SCM) at room temperature. UV reactors were constructed using perfluoroalkoxy (PFA) tubing having internal diameters of 1.6 and 3.2 mm and each had a residence time of 11.3 s. Four levels of Re were tested for each milk type, each tube size and each bacteria type. Inactivation efficiency increased as the Re increased in both the reactors for both types …

Holographic Recording In Corona Charged Acrylamide-Based Mfi-Zeolite Photopolymer, Temenujka Yovcheva, Izabela Naydenova, Simeon Sainov, Vincent Toal, Svetlana Mintova

Articles

The influence of corona charging on holographic recording in acrylamide-based photopolymer nanocomposite containing MFI zeolite nanoparticles has been studied. The holographic recording was carried out in two different geometries —transmission grating recording and total internal reflection grating recording. During the recording process, the layers were charged in a corona field. It was observed that independently of the corona polarity, in the case of transmission geometry of recording, the corona charging led to a decrease in the diffraction efficiency (DE) of the grating. In the case of the total internal reflection grating, the DE increased in the corona field presence.

Collateral Censorship And The Limits Of Intermediary Immunity, Felix T. Wu

Articles

The law often limits the liability of an intermediary for the speech it carries. And rightly so, because imposing liability on intermediaries can induce them to filter out questionable content and this “collateral censorship” risks suppressing much lawful, even highly beneficial, speech. The “collateral censorship” rationale has its limits, though, and correspondingly, so should the applicability of intermediary immunity. The worry with collateral censorship is not just that intermediaries censor, but that they censor more than an original speaker would in the face of potential liability. Increased censorship, in turn, is the product of applying liability targeted at original speakers …

On The N-Wave Equations And Soliton Interactions In Two And Three Dimensions, Vladimir S. Gerdjikov, Rossen Ivanov, Assen V. Kyuldjiev

Articles

Several important examples of the N-wave equations are studied. These integrable equations can be linearized by formulation of the inverse scattering as a local Riemann–Hilbert problem (RHP). Several nontrivial reductions are presented. Such reductions can be applied to the generic N-wave equations but mainly the 3- and 4-wave interactions are presented as examples. Their one and two-soliton solutions are derived and their soliton interactions are analyzed. It is shown that additional reductions may lead to new types of soliton solutions. In particular the 4-wave _{equations with} Z₂xZ₂ reduction group allow breather-like solitons. Finally it is demonstrated that …

The Impact Of Computer Self-Efficacy And Technology Dependence On Computer-Related Technostress: A Social Cognitive Theory Perspective, Qin Shu, Qiang Tu, Kanliang Wang

Articles

Professionals and end users of computers often experience being constantly surrounded by modern technology. One side effect of modern technology is termed technostress, which refers to the “negative impact on attitudes, thoughts, behaviors, or body physiology that is caused either directly or indirectly by technology” (Well and Rosen, 1997). Based on social cognitive theory, this study developed a conceptual model in which computer-related technostress was studied as consequences of computer self-efficacy and technology dependence. Results show that (a) employees with higher level of computer self-efficacy have lower level of computer-related technostress, (b) employees with higher level of technology dependence have …

Copyright, Fair Use, And The Creative Commons In The 21st Century, Megan Lotts

Articles

As our daily lives become consumed with the World Wide Web and all it has to offer, I question how we view or engage the notion of intellectual property. Is there a better way to share our ideas in our current technological climate without misusing or breaking the laws of Copyright? Is Creative Commons licensing a solution? This paper will briefly look at the World Wide Web and how Copyright law, fair use, and the Creative Commons apply in the 21st century.

George C Marshall: An Enduring Model Of Leadership Effectiveness, Jack Clarcq, Richard Demartino, Michael E. Palanski

Articles

General George C. Marshall is universally recognized as a paragon of leadership. Marshall’s effectiveness as the leader of the U.S. Army during World War II, the State Department during the early post-war era, and the Defense Department during the Korean War are well known and documented. As a result of his many accomplishments, a number of researchers and historians have explored traits and factors that underlie Marshall’s success. While many of these efforts provide insight into Marshall’s leadership style, none employ original data (interviews) specifically focused on leadership, management, and character. This paper is based on interviews conducted in 1998 …

Activation Of Mmp-9 By Human Lung Epithelial Cells In Response To The Cystic Fibrosis-Associated Pathogen Burkholderia Cenocepacia Reduced Wound Healing In Vitro, Ciara Wright ], Ruth Pilkington, Máire Callaghan, Siobhan Mcclean

Articles

Burkholderia cepacia complex is a group of bacterial pathogens that cause opportunistic infections in cystic fibrosis (CF). The most virulent of these is Burkholderia cenocepacia. Matrix metalloproteinases (MMPs) are upregulated in CF patients. The aim of this work was to examine the role of MMPs in the pathogenesis of B. cepacia complex, which has not been explored to date. Real-time PCR analysis showed that B. cenocepacia infection upregulated MMP-2 and MMP-9 genes in the CF lung cell line CFBE41o- within 1 h, whereas MMP-2, -7, and -9 genes were upregulated in the non-CF lung cell line 16HBE14o-. Conditioned media from …

The Designer Who Started A Print Revolution. Remembering Steve Jobs., John O'Connor

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Article commissioned by Irish Printer to commemorate Steve Jobs.

Application Of Baranyi Function To Model The Antibacterial Properties Of Solvent Extract From Irish York Cabbage Against Food Spoilage And Pathogenic Bacteria, Amit Jaiswal, Nissreen Abu-Ghannam, Shilpi Gupta, Sabrina Cox

Articles

Cabbage is a rich source of a number of bioactive compounds such as flavonoids, glucosinolates and their breakdown products which may have antibacterial, antioxidant and anticancer properties. Outer green leaves of York cabbage were extracted with 60% methanol, ethanol or acetone. Antibacterial activities of vacuum dried crude extracts were estimated against a number of Gram-positive and Gram-negative food spoilage and food pathogenic bacteria. The crude extracts showed a broad spectrum of antibacterial activities but 60% methanol extract exhibited the highest antibacterial effect. Complete growth inhibition for Listeria monocytogenes was achieved with an extract concentration of 1.4%, whereas a two-fold concentration …

Human Reliability Analysis In Healthcare, Esa M. Rantanen, Joe Deeter

Articles

The problem of human error in healthcare is well documented. Other domains (such as transportation and energy) have used techniques and methods from the engineering disciplines to analyze and ultimately reduce instances of error. In New York State (NYS), the Department of Health (DOH) requires the use of one such method, Root Cause Analysis (RCA), in investigating and reporting the occurrence of and response to sentinel events by hospitals. Despite the use of the RCA technique in an attempt to identify and mitigate the root causes of error, the problem of human error contributing to sentinel events persists. Experts in …

Country At A Crossroads: An Insight Into How An Economic Crisis Led To Dramatic Policy Change, John Hogan, Ana Maza

Articles

In this paper, we try to understand the nature of the changes to Mexican macroeconomic policy in the early 1980s using a critical juncture framework. The framework argues that three elements - crisis, ideational change, and radical policy change - must be identified in order for us to be able to declare, with some certainty, whether an event constitutes a critical juncture. Utilizing this framework, we will ascertain if the changes to Mexican macroeconomic policy constituted a clean break with the past, or were a continuation of previously established policy pathways.

Economic And Social Impacts Of Wildfires And Invasive Plants In American Deserts: Lessons From The Great Basin, Mark W. Brunson, John Tanaka

Articles

Research on the impacts of wildfire and invasive plants in rangelands has focused on biophysical rather than human dimensions of these environmental processes. We offer a synthetic perspective on economic and social aspects of wildfire and invasive plants in American deserts, focusing on the Great Basin because greater research attention has been given to the effects of cheatgrass expansion than to other desert wildfire/invasion cycles. We focus first on impacts at the level of the individual decision-maker, then on impacts experienced at the human community or larger socio-political scales. Economic impacts of wildfire differ from those of invasive grasses because …

Understanding And Supporting Young People Who Self Injure In Social Care Settings, David Williams

Articles

Abstract: this article provides a brief discussion on the issue of young people who self injure in social care settings. The discussion identifies this issue to be extremely challenging for social care workers caring for clients presenting with self injurious behaviour. The article focuses on providing some key definitions of self injury, identifies some key concepts in helping professionals understand the functions and reasons for self injurious behaviour and finally suggests some practical guidelines for social care workers in responding to young people in their care who harm themselves. The underlying ethos of these guidelines being the importance of using …

Ripe For The Plucking: Centralized And Consolidated Library Budgets As Revenue Streams For Profit., Roger Cross

Articles

The accumulation and centralization of fiscal and selection power into the hands of library professionals could have benefited all, but inherent flaws were bound to arise. In particular the failure to adapt to increased large profit-driven publishers business. Libraries and universities failed to adequately foresee the extent of publishing monopolization. The academic library, as provider of campus-wide journal subscription, reduced demand by reducing the need to maintain individual departmental and faculty subscriptions. The end result was that a small number of publishers were able to fix pricing according to desired profit margins.

Analysis Of The Use Of Ratios For Process Management And Decision-Making, Donald Holmes, A. Erhan Mergen

Articles

Ratios are commonly used in business for various applications, such as quality control, finance, sales, etc. The objective of this paper is to call attention to the possibility of the misuse of ratios used in monitoring processes and offer ways to avoid such misuse.

From Boom To Doom To Boom: Offshore Financial Centres And Development In Small States, Richard Woodward

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During the 1990s tax havens and offshore financial centres (OFCs) were subject to a string of initiatives designed to raise their tax and regulatory regimes to accepted international standards. Many commentators forecast that this would lead to the demise of OFCs, a worry for the many small states whose economic well being depended heavily on the provision of offshore financial services. Despite this regulatory onslaught many small state OFCs have prospered in the new millennium. This paper seeks to explain this apparent paradox by arguing that (1) international initiatives were riddled with loopholes and exceptions that have been gleefully seized …

"A Simple, Human Measure Of Privacy": Public Disclosure Of Private Facts In The World Of Tiger Woods, Patricia S. Abril

Articles

No abstract provided.

A Statistical Data Mining Approach To Determining The Factors That Distinguish Championship Caliber Teams In The National Football League, Ernest Fokoué, Dan Foehrenbach

Articles

This paper uses machine learning and data mining techniques to explore most of the performance measurements used in American football. The main goal is to determine/extract those factors that are most responsible for the success of the so-called great NFL teams. We consider a very large number of commonly used performance statistics and variables along with success indicators like winning percentage, playoff appearance, and championship wins. It is held by many football analysts/experts that defense wins championships. In this paper, we seek to establish if indeed there is ample evidence that the so called dominant teams are based on more …

A Review Of Zero Discharge Wastewater Treatment Systems Using Reed Willow Bed Combinations In Ireland, Sean O'Hogain, Liam Mccarton, Anna Reid, John Turner

Articles

The concept of a reed willow bed combination has the potential to achieve a zero discharge wastewater treatment system. This paper will present results from a two year study to monitor the performance of a reed willow bed facility at Lynches Lane, Co. Dublin, Ireland. Outline design specifications for the facility will be presented. Monitoring results for a two year period including influent and effluent parameters, rainfall, potential evapotranspiration, and soil classification will be presented and discussed. During the two year monitoring period the system achieved a zero discharge. This paper will discuss the potential widespread application of similar systems …

Studies Of Shrinkage As A Result Of Holographic Recording In Acrylamide Based Photopolymer Film, Mohesh Moothanchery, Izabela Naydenova, Vincent Toal

Articles

We studied the shrinkage in acrylamide-basedphotopolymer by measuring the Bragg detuning of transmission diffraction gratings recorded at different slant angles and at different intensities. Transmission diffraction gratings of spatial frequency 1000 lines/mm were recorded in an acrylamide-based photopolymer film having 60 ± 5 μm thickness. We have obtained the grating thickness and the final slant angles from the Bragg curve and hence calculated the shrinkage caused by holographic recording. The shrinkage of the material was evaluated for three different recording intensities 1, 5 and 10 mW/cm2, while the total exposure energy was kept constant at 80 mJ/cm2. From the experimental …

Optimisation Of Accelerated Solvent Extraction Of Antioxidant Compounds From Rosemary (Rosmarinus Officinalis L.), Marjoram (Origanum Majorana L.) And Oregano (Origanum Vulgare L.) Using Response Surface Methodology, M. Hossain, Catherine Barry-Ryan, Ana Belen Martin-Diana, N. Brunton

Articles

The present study optimised the accelerated solvent extraction (ASE) conditions (Dionex ASE® 200, USA) to maximise the antioxidant capacity of the extracts from three spices of Lamiaceae family; rosemary, oregano and marjoram. Optimised conditions with regard to extraction temperature (66–129 °C) and solvent concentration (32–88% methanol) were identified using response surface methodology (RSM). For all three spices results showed that 129 °C was the optimum temperature in order to obtain extracts with high antioxidant activity. Optimal methanol concentrations with respect to the antioxidant activity of rosemary and marjoram extracts were 56% and 57% respectively. Oregano showed a different response to …

Comparison Of Subcellular Responses For The Evaluation And Prediction Of The Chemotherapeutic Response To Cisplatin In Lung Adenocarcinoma Using Raman Spectroscopy, Haq Nawaz, Franck Bonnier, Aidan Meade, Fiona Lyng, Hugh Byrne

Articles

Confocal Raman Micro spectroscopy (CRM) is employed to examine the chemical and physiological effects of anticancer agents, using cisplatin and A549 adenocarcinoma cells as a model compound and test system respectively. Spectral responses of the membrane and cytoplasm of the cell are analysed independently and the results are compared to previously reported spectroscopic studies of the nucleus. Moreover, Raman spectra from the proteins extracted from the control and exposed samples are acquired and analysed to confirm the origin of the molecular changes of the cell membrane and cytoplasm of the A549 cells. Multivariate data analysis techniques including Principal Component Analysis …