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Journal Ida 2020 99 4 Aug 2026

Journal Ida 2020 99 4

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.


Journal Ida 2020 99 2 Aug 2026

Journal Ida 2020 99 2

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.


Journal Ida 2019 98 4 Aug 2026

Journal Ida 2019 98 4

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.


Journal Ida 2019 98 2 Aug 2026

Journal Ida 2019 98 2

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.


Distribution Of Urinary Calculi And Its Association With Clinical And Laboratory Findings In Dogs And Cats With Stone Analysis At Chulalongkorn Animal Teaching Hospital, Thailand (2020-2024), Tanattha Ladabornvidhaya, Natkrita Baikloy, Theaparak Thipjaroen, Parapond Kongrakchang, Warisara Kaechaiya, Sumonwan Chamsuwan, Monkon Trisiriroj, Chollada Buranakarl Aug 2026

Distribution Of Urinary Calculi And Its Association With Clinical And Laboratory Findings In Dogs And Cats With Stone Analysis At Chulalongkorn Animal Teaching Hospital, Thailand (2020-2024), Tanattha Ladabornvidhaya, Natkrita Baikloy, Theaparak Thipjaroen, Parapond Kongrakchang, Warisara Kaechaiya, Sumonwan Chamsuwan, Monkon Trisiriroj, Chollada Buranakarl

The Thai Journal of Veterinary Medicine

Urinary calculi are commonly encountered in veterinary practice; however, information regarding their distribution of stone that underwent analysis and associated clinical findings remains limited. This study investigated the distribution of urolithiasis and the associations between stone types and clinical and laboratory findings in dogs and cats presented to the Chulalongkorn Small Animal Teaching Hospital between 2020 and 2024. The three most common stone types in both species were calcium oxalate (CaOx), struvite, and urate, with relatively stable trends over the 5-year period. Small-breed dogs had a higher risk of developing CaOx urolithiasis than medium-breed dogs (OR = 10.4, 95% CI …


A Review On Traditional And Modern Aspects Of Vitex Negundo L.: Ethnomedicine, Phytochemistry, And Pharmacology, Tathagata Khanra, Suvasish Mitra, Subham Saha, Maitryee Mondal, Subhash C. Mandal Aug 2026

A Review On Traditional And Modern Aspects Of Vitex Negundo L.: Ethnomedicine, Phytochemistry, And Pharmacology, Tathagata Khanra, Suvasish Mitra, Subham Saha, Maitryee Mondal, Subhash C. Mandal

International Journal of Traditional Knowledge

Vitex negundo L., or five-leaved chaste tree, is a medicinally significant plant widely distributed in Asia and other tropical regions, frequently utilized in traditional healing systems for a spectrum of ailments. This comprehensive review consolidates current knowledge on the botany, traditional uses, phytochemical constituents, and pharmacological potentials of Vitex negundo L. The plant is rich in diverse bioactive compounds such as flavonoids, alkaloids, glycosides, and terpenoids, which are primarily responsible for its multidimensional therapeutic actions. Scientific investigations have substantiated its role in exerting anti-inflammatory, analgesic, antimicrobial, antioxidant, hepatoprotective, nephroprotective, insecticidal, anticancer, and antidiabetic effects, among others. Research reveals promising enzyme-inhibitory, …


Siddha Formulations: A Traditional Reservoir Of Valuable Medicines For The Contemporary World, Agnes Preethy Aug 2026

Siddha Formulations: A Traditional Reservoir Of Valuable Medicines For The Contemporary World, Agnes Preethy

International Journal of Traditional Knowledge

Traditional Medicine had been practised for many centuries in different parts of the world. However, the deep insights drawn from the traditional knowledge have remained highly localized as it had been privy only to the generations of traditional medicine practitioners. This, combined with lack of scientific evidence of their therapeutic action, had limited access, acceptance and awareness of these preparations to the larger segment of the community. The emergence of new lifestyle disorders and drug-resistant diseases in recent years has fuelled the search for alternate treatment strategies and has revived interest in traditional medicines. Concerted efforts to decipher the molecular …


Ayurvedic Herbs In The Management Of Benign Prostatic Hyperplasia: A Comprehensive Narrative Review, Latha Damle, Chandrasekhar C Aug 2026

Ayurvedic Herbs In The Management Of Benign Prostatic Hyperplasia: A Comprehensive Narrative Review, Latha Damle, Chandrasekhar C

International Journal of Traditional Knowledge

Benign Prostatic Hyperplasia (BPH) is a common, non-cancerous enlargement of the prostate gland, primarily affecting older men. It frequently leads to lower urinary tract symptoms (LUTS) such as increased urinary frequency, urgency, nocturia, and weak urine flow, which can significantly impair quality of life. Standard treatments for BPH include alpha-blockers, 5-alpha reductase inhibitors, and surgical interventions. However, limitations in efficacy and potential adverse effects have driven interest in complementary and traditional therapies, including Ayurveda. In Ayurvedic medicine, BPH is described as Mutraghata and Vatashthila, conditions attributed to an imbalance of Vata and Kapha doshas that disrupt normal prostate and …


Unveiling The Night-Flowering Jasmine: A Comprehensive Review Of Nyctanthes Arbor-Tristis’ (Oleaceae) Phytochemistry, Ethnomedicine, And Therapeutic Potential, Subham Saha, Soumya Mitra, Tathagata Khanra, Saban Karmakar, Tamalica Hore, Subhash C. Mandal Aug 2026

Unveiling The Night-Flowering Jasmine: A Comprehensive Review Of Nyctanthes Arbor-Tristis’ (Oleaceae) Phytochemistry, Ethnomedicine, And Therapeutic Potential, Subham Saha, Soumya Mitra, Tathagata Khanra, Saban Karmakar, Tamalica Hore, Subhash C. Mandal

International Journal of Traditional Knowledge

Nyctanthes arbor-tristis (NAT), typically known as Night-flowering Jasmine or Harsingar or Parijat, is one of the prominent medicinal plants indigenous to the Indian subcontinent. Its application dates back to ancient times, with substantial documentation in former religious texts. Native communities have traditionally used this for various human ailments and as an ornamental plant. Leaves, flowers, seeds and stems of this plant are rich in various primary and secondary metabolites, providing a wide range of pharmacological effects. The most abundantly found phytoconstituents belong to iridoid glycosides, such as arbortristosides. Comprehensive research has investigated its potential in anticancer, antiviral, and anti-inflammatory activities, …


Addressing Sustainability Challenges: Perspectives From Bhagavad Gītā, B Mahadevan, Dhrithi Mahadevan Aug 2026

Addressing Sustainability Challenges: Perspectives From Bhagavad Gītā, B Mahadevan, Dhrithi Mahadevan

International Journal of Traditional Knowledge

The industrialization-driven growth has ushered in economic progress over the past few centuries. However, it has also raised serious concerns about the sustainability of life on this planet. Despite considerable attempts to address sustainability issues using newer frameworks and efforts by corporates as well as governmental, and non-governmental institutions, we have remained ineffective in implementing sustainable solutions. The “last mile” to successfully implementing sustainable solutions is the individual. This calls for addressing individual values and aligning them to sustainability. This paper presents a fresh perspective on the problem by drawing some insights from the Bhagavad Gītā. We introduce the basic …


Agrarian Festivals Of India- Embedded Traditional Knowledge About Environment And Ecology Preserved Across Millennia, Lopamudra Maitra Aug 2026

Agrarian Festivals Of India- Embedded Traditional Knowledge About Environment And Ecology Preserved Across Millennia, Lopamudra Maitra

International Journal of Traditional Knowledge

With a prominent agrarian economy, it is important to note the many agrarian festivals from across the nation. These festivals also help to highlight many rites, rituals and folklore, which forms the basic ethos of the celebrations and within the many layers of these are embedded knowledge about environment and ecology, which has been passed down through thousands of centuries. These have also been variously corroborated through archaeological, historical and epigraphical records of ancient India. This paper is an attempt to highlight this historicity of the agrarian festivals of India, which also corresponds to the mainstream festivals from across India, …


Gaining From Captured Indian Traditional Knowledge Systems: Paths Taken And Way Forward, Ramasami T Aug 2026

Gaining From Captured Indian Traditional Knowledge Systems: Paths Taken And Way Forward, Ramasami T

International Journal of Traditional Knowledge

India’s scientific heritage is deeply reflected in Ayurveda, a tradition of integrative medicine documented for over two millennia. P.C. Ray, the father of modern chemistry in India, highlighted the depth of ancient chemical knowledge and early use of mercury compounds, while M.S. Valiathan later revived and analyzed the classical texts of Charaka, Sushruta, and Vagbhata to bridge Ayurveda with modern science. Building on this foundation, the Government of India launched initiatives linking Ayurveda with genomics, personalized medicine, and rasayana therapies, yielding promising insights such as the genetic basis of prakriti classifications and protective effects of Amalaki Rasayana. Efforts like the …


Getting Money Out Of Politics By Putting Money Into Politics: A Few Modest Proposals To Reform Seattle’S Democracy Voucher Program, Decker O’Donnell Aug 2026

Getting Money Out Of Politics By Putting Money Into Politics: A Few Modest Proposals To Reform Seattle’S Democracy Voucher Program, Decker O’Donnell

Seattle University Law Review

Seattle’s Democracy Voucher Program offers an unconventional response to the growing influence of money in American elections: rather than restricting political spending, it seeks to amplify the participation of ordinary voters by providing publicly funded vouchers that residents may assign to participating candidates. This Article examines the program’s development, operation, and constitutional foundation within the modern campaign-finance framework established by Buckley v. Valeo and subsequent Supreme Court decisions. It argues that democracy vouchers provide a constitutionally viable means of broadening participation in campaign financing while mitigating the influence of wealthy donors. The Article identifies two weaknesses in the current system: …


Retrieval Strategies For Embolized Left Atrial Appendage Closure Devices, Usama Sadiq, Muneeba Ali, Stacey Damito, Maxwell Ambrosino, Muhammad Sabri, Muhammad Ahmad Sadiq, Muhammad Hamza Sadiq, Richard Kovach, Sheena Rastogi, Muhammad Raza Aug 2026

Retrieval Strategies For Embolized Left Atrial Appendage Closure Devices, Usama Sadiq, Muneeba Ali, Stacey Damito, Maxwell Ambrosino, Muhammad Sabri, Muhammad Ahmad Sadiq, Muhammad Hamza Sadiq, Richard Kovach, Sheena Rastogi, Muhammad Raza

Abington Jefferson Health Papers

BACKGROUND: Device embolization (DE) is a rare but potentially life-threatening complication of left atrial appendage occlusion (LAAO). As landmark trials broaden the eligible population for LAAO, operator preparedness for DE management becomes increasingly critical.

CASE SUMMARY: We present 4 cases of LAAO DE managed with distinct retrieval strategies: 1) open surgical retrieval with concurrent AtriClip ligation for an endothelialized left atrial device; 2) sequential transseptal then retrograde arterial snaring for intraprocedural migration to the abdominal aorta; 3) transseptal retrieval using a dedicated ONO system with cerebral embolic protection for partial left atrial dislodgment; and 4) retrograde large-bore arterial retrieval for …


Presence And Impact Of Herbicides On Intertidal Benthic Communities, Marco Sanderson Aug 2026

Presence And Impact Of Herbicides On Intertidal Benthic Communities, Marco Sanderson

Electronic Theses and Dissertations

The growing reliance and widespread use of herbicides on a global scale is negatively affecting non-targeted biota and, consequently, their ecosystems. Herbicide levels and their impacts have been extensively researched around the world in riverine and lacustrine ecosystems. However, studies of the levels and effects of herbicides on coastal intertidal benthic communities have been lacking. This study focused on testing spectrophotometric methodologies for herbicides (atrazine and glyphosate) and documenting their presence and levels in sediment, water, and biotic tissue of intertidal coastal beaches and marshes of Waties Island and Singleton Swash, Horry County, South Carolina. A laboratory microcosm was employed …


Trophic Ecology Of A South Carolina Estuarine Predator Guild, Shane John Molander Aug 2026

Trophic Ecology Of A South Carolina Estuarine Predator Guild, Shane John Molander

Electronic Theses and Dissertations

Estuaries are among the world’s most productive ecosystems in the world and are characterized by the convergence of two distinct habitats, creating a mosaic of environmental conditions from inland rivers to the nearshore ocean. Many fishes occupy estuaries during various life stages for growth, reproduction, or foraging, and may reside in them seasonally. The co-occurrence of species, particularly upper-trophic level carnivores, can result in competitive interactions for prey resources within a shared environment. Identifying the degree of these interactions as well as understanding basal energy consumption can inform food web dynamics and how overlapping species use shared spaces. I used …


Altered Postnatal Chromatin Development In The Nucleus Accumbens Primes Enduring Stress Sensitivity, Rebekah L Rashford, Lisa Z Fang, Michael Deberardine, Hye Ji J Kim, Laura W Hirschfield, Ella Cervi, Mason R Barrett, Jeremy M Thompson, Meaghan C Creed, Catherine Jensen Peña Aug 2026

Altered Postnatal Chromatin Development In The Nucleus Accumbens Primes Enduring Stress Sensitivity, Rebekah L Rashford, Lisa Z Fang, Michael Deberardine, Hye Ji J Kim, Laura W Hirschfield, Ella Cervi, Mason R Barrett, Jeremy M Thompson, Meaghan C Creed, Catherine Jensen Peña

2020-Current year OA Pubs

Early life stress (ELS) sensitizes individuals to subsequent stressors to increase lifetime risk for psychiatric disorders. Within the nucleus accumbens (NAc)-a key limbic and reward-associated brain region-ELS sensitizes both cellular and transcriptional response to later stress, which are programmed by enduring epigenetic changes. Among the histone modifications persistently enriched by ELS in NAc is H3K4me1, which is associated with open chromatin and epigenetic priming of genomic enhancers. Here, we sought to determine whether H3K4me1 enrichment in NAc was sufficient to prime cellular and behavioral responses to adult stress. Viral-mediated overexpression of the histone H3 monomethyltransferase


The Varieties Of Precaution: Which Risks, Whose Attitudes?, Tomasz Żuradzki Aug 2026

The Varieties Of Precaution: Which Risks, Whose Attitudes?, Tomasz Żuradzki

Animal Sentience

The Edge of Sentience offers an ambitious and timely institutional framework for proportionate precaution under uncertainty about sentience. Its systematic treatment of empirical and theoretical uncertainty across diverse cases is a major contribution. Focusing on the problem of identifying and weighing different risks when designing proportionate precautions, this commentary suggests three areas in which Birch’s framework could be developed further: a more domain-sensitive justification of the priority given to avoiding under-attribution; a clearer distinction among competing forms of risk aversion and their divergent policy implications; and a fuller explanation of how the framework generates different recommendations across cases.


Credence Goods In Markets With Collective Reputation: Nature Of Equilibria And The Value Of Certification, Erin Krupka, Thomas P. Lyon, Arnab Mitra Aug 2026

Credence Goods In Markets With Collective Reputation: Nature Of Equilibria And The Value Of Certification, Erin Krupka, Thomas P. Lyon, Arnab Mitra

Economics Faculty Publications and Presentations

Fraud can cause markets for credence goods to collapse, but collective reputation has been suggested as a potential solution, especially when buyer valuations for quality are high. We develop a discrete model of a market for label credence goods and provide conditions for no-fraud equilibria based on collective reputation. We identify conditions under which all equilibria may be asymmetric or involve mixed strategies and hence sellers may face coordination problems. Our analysis suggests such coordination problems are the greatest when the size of the high-quality market is approximately half of the overall market (that incorporates both high- and low-quality goods), …


Llm-Integrated Anomaly Detection For Iot Networks: Framework Structure, Mamoon M. Saeed, Rashid A. Saeed, Salah Hagahmoodi, Rania A. Mokhtar, Khalid Hamid Aug 2026

Llm-Integrated Anomaly Detection For Iot Networks: Framework Structure, Mamoon M. Saeed, Rashid A. Saeed, Salah Hagahmoodi, Rania A. Mokhtar, Khalid Hamid

Baghdad Science Journal

Internet of Things (IoT) devices are vulnerable to zero-day attacks because most of them have weak or no inherent security due to the resource constraints of the devices. This weakness underscores the growing need for anomaly-based intrusion detection systems tailored to IoT networks. Nevertheless, general anomaly detection traditionally has a high number of false positives that drain analysts' time. Also, a semantic difference exists between the system's results and the operators' interpretations. We introduce a machine learning-based framework to tackle these issues in traditional systems in this paper by combining large language models (LLMs). Our model is effective in identifying …


Video Steganography Based On Invertible Neural Networks With Densenet And U-Net Features, Noor Fahem Sahib, Soukaena Hassan Hashem, Ekhlas Falih Naser Aug 2026

Video Steganography Based On Invertible Neural Networks With Densenet And U-Net Features, Noor Fahem Sahib, Soukaena Hassan Hashem, Ekhlas Falih Naser

Baghdad Science Journal

The increased rate of cyber threats such as fraud and other forms of attack, including phishing, malware, and denial-of-service attacks, has led to a growing demand for secure methods to ensure the security of sensitive information that is transferred among users. Video steganography has become a very important element in dealing with these security issues, as communication has become more dependent on multimedia content. Hiding information is now an area that is being developed very fast with the introduction of Deep Learning (DL)-based steganography methods. This framework introduces Vid_Steg_DenseUNet, a video steganography method which efficiently extracts multi-level features using edge-preserving …


Qrc-Pso: A Quad-Module Ring-Competitive Pso Algorithm For Coverage Optimization In Wireless Sensor Networks, Yu-Xuan Zhou, Shao-Qiang Ye, Di-Wen Kang, Xue-Wei Liu, Kai-Qing Zhou Aug 2026

Qrc-Pso: A Quad-Module Ring-Competitive Pso Algorithm For Coverage Optimization In Wireless Sensor Networks, Yu-Xuan Zhou, Shao-Qiang Ye, Di-Wen Kang, Xue-Wei Liu, Kai-Qing Zhou

Baghdad Science Journal

Coverage optimization in WSNs is critical for disaster warning and industrial monitoring, but is challenging due to multi-modality and high-dimensionality. Particle swarm optimization (PSO) offers fast convergence and simple parameter tuning, yet suffers from premature convergence and parameter sensitivity in multi-peak problems. To address these issues, we propose a Quad-module Ring-Competitive PSO (QRC-PSO). It comprises four heterogeneous subgroups with distinct parameter configurations for global exploration, local exploitation, balanced search, and perturbation enhancement. Subgroups evolve independently but exchange elite particles via a ring-topology migration strategy: every 20 iterations, the best three particles of each subgroup move clockwise to the next subgroup …


A New Reptile Search Algorithm For An Intelligent Video Retrieval System, Ansam Nazar Younis, Fawziya Mahmood Ramo Aug 2026

A New Reptile Search Algorithm For An Intelligent Video Retrieval System, Ansam Nazar Younis, Fawziya Mahmood Ramo

Baghdad Science Journal

The increasing volume of videos produced and shared via smart devices has made indexing and retrieving them a clear challenge. Current retrieval systems, such as specialized video retrieval systems, rely on text-based searches, which often misrepresent and frequently result in erroneous descriptions of the requested video, particularly when it comes to videos about certain specialities like security or medical procedures that are hard to describe. As a result, we developed a model that handles information-rich video queries, making it easier to find related videos that are specifically relevant to the user's needs. This paper proposes a new method for indexing …


Who Decides The Dead? Interpreting Washington’S Disposition Of Remains Statute, Wyatt Young Aug 2026

Who Decides The Dead? Interpreting Washington’S Disposition Of Remains Statute, Wyatt Young

Seattle University Law Review

Washington’s disposition-of-remains statute, RCW 68.50.160, is designed to honor a decedent’s expressed wishes regarding the control and disposition of their body after death. Yet recent litigation reveals a critical gap between the statute’s intent-centered design and its practical enforceability. In Larotonda v. Blackburn, a trial court acknowledged that irreparable harm would occur if a decedent’s burial wishes were ignored but nonetheless denied relief on the grounds that the individual designated to carry out those wishes lacked standing. The result was a legal paradox: a statute that recognizes decedent autonomy in theory but withholds any meaningful mechanism for its enforcement …


Legal Malpractice In Washington: Use Of The Rules Of Professional Conduct, Angelo Tadrous Aug 2026

Legal Malpractice In Washington: Use Of The Rules Of Professional Conduct, Angelo Tadrous

Seattle University Law Review

Legal malpractice claims are difficult to prove. They are difficult to prove because many jurisdictions require that a plaintiff prove that, but for the lawyer’s misconduct, the client would have fared better. Thus, in a malpractice suit, a plaintiff must try a case within a case. Despite this difficulty, many jurisdictions prohibit the use of the Rules of Professional Conduct when litigating a malpractice case. Washington State is one of these jurisdictions. The Washington Supreme Court held in Hizey v. Carpenter that the Rules of Professional Conduct may not be referred to during trial. This Note argues that this prohibition …


Converting Buildings Is Hard: Why Seattle’S Municipal Government Should Streamline Commercial-To-Residential Conversions, Tyler M. King Aug 2026

Converting Buildings Is Hard: Why Seattle’S Municipal Government Should Streamline Commercial-To-Residential Conversions, Tyler M. King

Seattle University Law Review

The conversion of commercial buildings into housing is a promising solution to the growing housing crisis in many urban areas. However, despite its potential benefits, the process of repurposing commercial spaces is often stymied by complex zoning codes, high conversion costs, and bureaucratic hurdles. This Article argues that the local and state governments in Seattle should adopt more streamlined policies and offer greater incentives to developers to facilitate these conversions. By reforming zoning regulations and providing targeted financial support, municipalities can reduce the barriers to conversion and unlock the potential of underutilized commercial properties. This article examines the legal and …


Translational Initiative To Minimize Childhood Hemiparesis After Asymmetrical Perinatal Brain Injury, Susan V. Duff, Emily Garavatti, Terrie Inder Aug 2026

Translational Initiative To Minimize Childhood Hemiparesis After Asymmetrical Perinatal Brain Injury, Susan V. Duff, Emily Garavatti, Terrie Inder

Physical Therapy Faculty Articles and Research

The purpose of this perspective paper is to present a translational approach aimed at identifying the critical periods in brain development during which to provide neuroprotective and neurorestorative strategies, followed by prehensile training, to minimize hemiparesis and foster skill acquisition after asymmetrical perinatal brain injury (APBI). We contend that hemiparesis could be minimized after APBI through a multimodal sequential approach based on timely implementation of evidence-based intervention strategies. If APBI is identified early, neuroprotective techniques can be used in the first 10 days of life to minimize cell death. This can be followed in the next 3 months by the …


How Does The Science Of Reading Approach Enhance Small Reading Group Instruction?, Destiny M. Morman Aug 2026

How Does The Science Of Reading Approach Enhance Small Reading Group Instruction?, Destiny M. Morman

Graduate Teacher Education

This paper examined how the Science of Reading (SOR) practices enhance student success in small-group reading. Specifically, the purpose of this research is to analyze which SOR-aligned instructional practices are the most beneficial for promoting student success in small-group settings and to examine practices that may be less effective. Effective reading practices are crucial for small-group instruction (Smith et al., 2022). When instruction is strategically designed around students’ specific reading needs, educators can provide a more targeted and personalized support that may be difficult to achieve during whole-group instruction. During small-group learning, teachers can differentiate instruction by aligning lessons with …


Lindenwood Digest, August 26, 2026, Lindenwood University Aug 2026

Lindenwood Digest, August 26, 2026, Lindenwood University

Lindenwood Digest

  • Event & Date: The Lindenwood University Employee Digest was published on August 26, 2026, detailing campus schedules including the August 27, 2026 football home opener against Charleston Southern and the August 31, 2026 Library Services Documentary Night.

  • Geographic Grounding: Activities and facilities referenced are situated at the Library and Academic Resources Center (LARC) and the Spellmann Campus Center, Lindenwood University, St. Charles, Missouri.

  • Institutional Context: Academic Services transitioned its institutional title, forms, and primary administrative contacts to the Office of the Registrar effective for the Fall 2026 term.


Heritable Transgenic Schistosomes As A Living Platform For Sars-Cov-2 Neutralizing Antibody Secretion, Wannaporn Ittiprasert, Bruce A Rosa, Sergej Djuranovic, Makedonka Mitreva, Et Al. Aug 2026

Heritable Transgenic Schistosomes As A Living Platform For Sars-Cov-2 Neutralizing Antibody Secretion, Wannaporn Ittiprasert, Bruce A Rosa, Sergej Djuranovic, Makedonka Mitreva, Et Al.

2020-Current year OA Pubs

We report the generation and propagation of not only the first heritable transgenic schistosome line but also a line that secretes a functional therapeutic protein in vivo. Using multiplexed CRISPR/Cas-mediated homology-directed knock-in targeted to a predicted genomic safe-harbor, we inserted a VHH-IgG1 Fc (termed C5-Fc) transgene into Schistosoma mansoni eggs. Single-miracidium infections of Biomphalaria glabrata yielded parental P0 lines; serial passage through snail and mouse hosts produced an F2 cohort in which all parasites carried the C5-Fc transgene and secreted C5-Fc into the murine venous circulation. Molecular assays confirmed chromosomal insertion, germline transmission and systemic secretion. Sera from mice harboring …