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Evaluating Multiparametric Imaging Biomarkers For Guiding Targeted Therapies In Her2+ Breast Cancer, Ameer Mansur
Evaluating Multiparametric Imaging Biomarkers For Guiding Targeted Therapies In Her2+ Breast Cancer, Ameer Mansur
All ETDs from UAB
Human epidermal growth factor receptor 2 positive (HER2+) breast cancer is a biologically diverse disease, in which intratumoral heterogeneity plays a significant role in tumor progression. Advanced medical imaging and image processing techniques offer the potential to noninvasively characterize the underlying intratumoral biology. Capturing these complex changes can allow for assessing therapeutic response and eventually guiding personalized therapeutic strategies. This work evaluates single and multiparametric imaging biomarkers to characterize tumor biology, identify treatment-induced changes, and predict response to targeted therapies. First, the utility of 3’-Deoxy-3’-[18F]Fluorothymidine positron emission tomography ([18F]FLT-PET) was assessed as a biomarker of proliferation for monitoring response to …
Maternal Immune Activation Causes Oligodendrocyte Deficits In The Hypothalamus, Kate Miller
Maternal Immune Activation Causes Oligodendrocyte Deficits In The Hypothalamus, Kate Miller
All ETDs from UAB
Maternal immune activation (MIA) refers to the occurrence of an inflammatory immune response during any stage of pregnancy. This manifests as the upregulation of proinflammatory cytokines and can be caused by air pollution, obesity, or viral infection. When this occurs during the first trimester in humans, it increases the offspring’s susceptibility to developing neuropsychiatric disorders such as autism (ASD) and schizophrenia (SZ), in males more commonly than females. In addition to behavioral manifestations of neuropsychiatric disorders, metabolic syndrome (MetS) is a common comorbidity, defined as the co-occurrence of three or more symptoms including but not limited to hyperlipidemia, hypertension, and …
Therapeutic Implications Of Fractionated Radiotherapy And Marcks’ Regulation Of Tunneling Nanotubes In Glioblastoma, Lauren Catherine Nassour-Caswell
Therapeutic Implications Of Fractionated Radiotherapy And Marcks’ Regulation Of Tunneling Nanotubes In Glioblastoma, Lauren Catherine Nassour-Caswell
All ETDs from UAB
Glioblastoma (GBM) is the most common primary brain malignancy in adults and the gradual development of treatment resistance prevents patients from achieving remission. A primary objective in the field is to devise strategies to overcome this. We predicted this could be achieved by improving existing therapies, creating better models to study GBM, and by identifying a potential therapeutic target. Fractionated radiotherapy (RT) has been used in GBM standard of care for over a century but does not account for GBM heterogeneity. We first hypothesized that in silico mathematical modeling would be a useful tool for cytotoxicity prediction. While this model …
Environmental Exposure To Metals In Children And Their Effects On Autism Spectrum Disorder, Oludesola Ogunesan
Environmental Exposure To Metals In Children And Their Effects On Autism Spectrum Disorder, Oludesola Ogunesan
All ETDs from UAB
ABSTRACT As scientific understanding of environmental determinants of health advances, growing attention has turned to the role of toxic metal exposures in exacerbating neurodevelopmental outcomes, particularly in vulnerable populations such as children with autism spectrum disorder (ASD). This dissertation investigates the intersection of environmental metal exposure, biomonitoring innovation, and social factors shaping ASD severity in Alabama. Using a multidisciplinary framework, four interrelated studies explore biological, environmental, and participatory dimensions of ASD research and public health. The first study evaluates the utility of Volumetric Absorptive Microsampling (VAMS) for measuring exposure to cadmium (Cd), chromium (Cr), lead (Pb), manganese (Mn), and mercury …
An Examination Of Sleep Quality And Experimental Pain Sensitivity In People With Hiv And Insomnia, Caroline Kathryn Webb
An Examination Of Sleep Quality And Experimental Pain Sensitivity In People With Hiv And Insomnia, Caroline Kathryn Webb
All ETDs from UAB
Prior research has established a bidirectional relationship between sleep and pain, yet this relationship has been understudied in people living with HIV. The current study investigated the relationship between HIV status (H+/H-) and insomnia status (I+/I-) on sleep and quantitative sensory testing (QST) variables. The study was comprised of two research visits where participants were screened and completed the QST protocol. Participants completed the Insomnia Severity Index (ISI), Dysfunctional Beliefs and Attitudes about Sleep (DBAS), and actigraphy as subjective and objective measures of sleep. There were four groups: H-/I- (n=46), H-/I+ (n=37), H+/I- (n=14), and H+/I+ (n=39) (N=136). Results showed …
Exploring Environmental Health Awareness And Knowledge In 9th – 12th Grade Students: A Mixed Methods Approach, Crystal Stephens
Exploring Environmental Health Awareness And Knowledge In 9th – 12th Grade Students: A Mixed Methods Approach, Crystal Stephens
All ETDs from UAB
EXPLORING ENVIRONMENTAL HEALTH AWARENESS AND KNOWLEDGE IN 9TH – 12TH GRADE STUDENTS: A MIXED METHODS APPROACH CRYSTAL T. STEPHENS ENVIRONMENTAL HEALTH SCIENCES ABSTRACT Safe environments provide accessibility and community protections preventing residents from exposure to contaminants or facing health risks. Unfortunately, environmental exposures such as air pollution and neighborhood-level concerns can adversely impact human health. Environmental justice communities are overburdened with increased adverse environmental exposures and subsequent health disparities. Adolescents may be more vulnerable to exposure risks and provide an opportunity to introduce environmental health education. With their power of peer association and determination, adolescents can influence the health and …
Child Risk For Obesity And Physical Activity, Bethany Moore
Child Risk For Obesity And Physical Activity, Bethany Moore
All ETDs from UAB
Childhood obesity is a significant health problem in the United States with consequences presenting themselves in the short- and long-term. Physical activity is a modifiable factor associated with adiposity and can at least partially attenuate the consequences of childhood obesity. There are many factors which influence children’s participation in regular physical activity, some of which are also associated with pediatric obesity. The overarching purpose of this research is to investigate potential influences on the association of obesity and physical activity among typically developing children. Aim 1 used a secondary analysis of n=163 children to explore independent and interactive effects of …
O-Glcnac Transferase Regulates Tgf-Β Signaling And Fibrotic Resolution In Idiopathic Pulmonary Fibrosis, Shia Vang
All ETDs from UAB
Idiopathic pulmonary fibrosis (IPF) is a progressive, chronic lung disease that causes scarring of the lungs. IPF is often characterized by altered growth factor signaling, excessive extracellular matrix (ECM) deposition, fibroblast hyperproliferation, and dysregulated metabolism. The etiology of IPF is unknown, but fibroblasts and myofibroblasts are the known effector cells in IPF pathology. Current treatments, such as pirfenidone and nintedanib, target growth factor signaling pathways to slow fibrogenesis, but are unable to cure the disease. The transforming growth factor-beta (TGF-β) is a master regulator of fibrosis, including IPF, and is a powerful inducer of the fibroblast-to-myofibroblast transition (FMT). In IPF, …
Purple Glass, Madyson Nicole Reynolds
Purple Glass, Madyson Nicole Reynolds
All ETDs from UAB
Purple Glass is a fiction novel that compiles themes of high school, family expectations, twin sibling rivalries, and the significance of historical landmarks through the environmental fantasy genre. The story takes place in the author’s hometown of Springville, Alabama, and is inspired by real events that happened at the former Springville Lake. This work is a testament to the power of nature and its unseen magic that remains present, even amidst environmental tragedy. This work is also about self-discovery and the examination of one’s place within their personal and natural environment.
Neighborhood Disadvantage, Parenting, And Dna Methylation During Childhood, Malcolm Barker-Kamps
Neighborhood Disadvantage, Parenting, And Dna Methylation During Childhood, Malcolm Barker-Kamps
All ETDs from UAB
Being raised in a disadvantaged neighborhood increases the risk of adult obesity, chronic inflammation, and epigenetic aging even when adjusting for family socioeconomic status (SES). Because little is understood regarding the timing of these outcomes through development and possible moderating effects of the family environment, this project investigated the relationship between neighborhood disadvantage and DNA methylation in children and whether this association varies across child age, parenting behaviors, or neighborhood cohesion. The study included 112 parents (Mage=27.5; SD=1.06) and 160 children, ages 0-14 (Mage =3.89, SD=3.29; 54% female; 90% African American; 10% White), from the Birmingham Youth Violence Study. Neighborhood …
Investigating The Role Of The Static And Hyperviscous Mucus Defect On The Development Of Bacterial Infection In The Cystic Fibrosis Rat, Mikayla Murphree-Terry
Investigating The Role Of The Static And Hyperviscous Mucus Defect On The Development Of Bacterial Infection In The Cystic Fibrosis Rat, Mikayla Murphree-Terry
All ETDs from UAB
INVESTIGATING THE ROLE OF THE STATIC AND HYPERVISCOUS MUCUS DEFECT ON THE DEVELOPMENT OF BACTERIAL INFECTION IN THE CYSTIC FIBROSIS RAT MIKAYLA MURPHREE-TERRY GRADUATE BIOMEDICAL SCIENCES - MICROBIOLOGY ABSTRACT Cystic fibrosis (CF) is a genetic disease caused by mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, resulting in dysfunctional CFTR. In the lungs, CFTR dysfunction results in dehydrated mucus that is adherent to epithelia. In the gut, thick mucus can mix with feces to form an obstruction, known as distal intestinal obstruction syndrome (DIOS). Additionally, CF mucus has a higher percentage of solids. The main solid component of …
Oral Administration Of Alpha-Cyclodextrin Corrects Diabetes Induced Retinopathy And Bone Marrow Pathology By Modulation Of The Gut-Retina Axis., Yvonne Adu-Agyeiwaah
Oral Administration Of Alpha-Cyclodextrin Corrects Diabetes Induced Retinopathy And Bone Marrow Pathology By Modulation Of The Gut-Retina Axis., Yvonne Adu-Agyeiwaah
All ETDs from UAB
Diabetic retinopathy represents a common complication of diabetes, exerting a significant financial burden globally across nations, particularly impacting the working-age population and thereby affecting productivity. Extensive investigations have unveiled its multifaceted etiology, implicating a convergence of diverse causative factors. Notably, seminal studies such as the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Eye Study have underscored the pivotal role of cholesterol dysregulation and dyslipidemia in the pathogenesis of diabetic retinopathy. This dysregulation stems from an imbalance characterized by heightened cholesterol production coupled with deficient cholesterol efflux or removal mechanisms. Liver X receptors (LXRs), ligand-activated nuclear receptors function in transcriptional …
Effects Of Probiotic Lactobacilli On Candida Albicans: Implications For Early Childhood Caries, Leena Unnikrishnan Menon
Effects Of Probiotic Lactobacilli On Candida Albicans: Implications For Early Childhood Caries, Leena Unnikrishnan Menon
All ETDs from UAB
Purpose: Probiotic Lactobacillus species are shown to have beneficial effects against early childhood caries (ECC). On the other hand, the wide use of probiotic Lactobacillus spp. in dairy foods is believed to underline the global increase in ECC prevalence. Candida albicans has been frequently detected in children with ECC and has shown cariogenic potential in animal models of dental caries. The objective of this study was to determine the interactions between lactobacilli and C. albicans in growth competition, biofilm formation and acid production. Methods: Growth competition between C. albicans SC5314 and probiotic L. rhamnosus GG or caries-associated L. rhamnosus M72-26 …
Coyote Play: A Critical Inquiry Of Power At A Nature-Based Preschool, Timothy Mckenzie
Coyote Play: A Critical Inquiry Of Power At A Nature-Based Preschool, Timothy Mckenzie
All ETDs from UAB
The distribution of power in the educational institution exists as a hierarchy from governing bodies to the masses. This causes children within the institution to align themselves with the institution rather than the institution meeting the needs of the children it serves. The purpose of this study is to examine how children engage with power at a nature-based preschool. The researcher used data from field observations and programmatic resources to analyze the power enacted by children. The researcher found that the children enact power through structures, to define place, care for themselves, and care for others. The implications of this …
Non-Invasive Pet Imaging Probes For Immune Activation And Fibrosis In Cancer And Pulmonary Fibrosis, Yujun Zhang
Non-Invasive Pet Imaging Probes For Immune Activation And Fibrosis In Cancer And Pulmonary Fibrosis, Yujun Zhang
All ETDs from UAB
Immune activation plays an important role in the development and treatment of tumor and fibrotic diseases. Granzyme B is a serine protease granzymes secreted by cytotoxic T cells or natural killer (NK) cells, which induces target cell apoptosis. Measuring granzyme B level is a way to quantify immune activation non-invasively. [68Ga]-NOTA-GZP PET imaging was applied in 4T1 breast cancer mouse model and LLC non-small cell lung cancer mouse model after treated with combination of 12 Gy irradiation and dual checkpoint inhibitors. There was a tumor growth and metastasis inhibition in the combination treatment group. The uptake of [68Ga]-NOTA-GZP on day …
Multi-Omics Analysis Of Nf1 Deficiency In Various Cell Types Implicates Roles Outside Of Ras For Cells And Their Microenvironment, Christian Xavier Fay
Multi-Omics Analysis Of Nf1 Deficiency In Various Cell Types Implicates Roles Outside Of Ras For Cells And Their Microenvironment, Christian Xavier Fay
All ETDs from UAB
Neurofibromatosis type 1 is an autosomal dominant disease in which many patients develop the hallmark feature, neurofibromas, benign tumors that develop along the peripheral nerves. Currently there is no known cure for NF1, and more than 3000 germline pathogenic variants (PVs) in NF1 have been observed. The neurofibromin gene encodes the 320kDa NF1 protein which has multiple predicted functions. Its most under-stood molecular role is in binding GTP-Ras and stimulating Ras-GTPase to cleave GTP to GDP and inactivate Ras signaling. In fact, the only FDA-approved therapeutic is the MEK inhibitor selumetinib which acts downstream of Ras. NF1 also has Ras …
Phylogenetic Diversity Of Flagellin Differentiates Commensal Gut Bacteria That Induce Distinct Intestinal Epithelial Cell Responses, Melissa Simone Jennings
Phylogenetic Diversity Of Flagellin Differentiates Commensal Gut Bacteria That Induce Distinct Intestinal Epithelial Cell Responses, Melissa Simone Jennings
All ETDs from UAB
Flagellins belonging to bacteria from the Lachnospiraceae family are immunodom-inant antigens in inflammatory bowel disease. Flagellin, the basic unit of flagella utilized by bacteria for motility, is recognized by the host via toll-like receptor 5 (TLR5). Due to the diversity of flagellated bacteria, we investigated if this diversity results in distinct interac-tions between the bacteria and the host. Phylogenetic analysis on over 200 flagellin se-quences, primarily from Lachnospiraceae bacteria, revealed two divergent clusters we refer to as Group 1 (G1) and Group 2 (G2). In gnotobiotic mice colonized with G1 or G2 bacte-ria, both groups induce colonic interleukin 10 (IL-10)-producing …
Investigating Molecular Mechanisms Behind Neuronotypic Gba1 Mutations In Lewy Body Dementias, Casey Mahoney-Crane
Investigating Molecular Mechanisms Behind Neuronotypic Gba1 Mutations In Lewy Body Dementias, Casey Mahoney-Crane
All ETDs from UAB
Nonmotor deficits are present in nearly all Parkinson’s disease (PD) patients, with ~80% of these patients developing dementia. Importantly, expression of the severe GBA1 L444P heterozygous mutation increases the risk for Parkinson’s disease devel-opment by 5.43 times compared to mild mutation carriers. Currently, many PD treat-ments predominately focus motor symptoms, while treatments for nonmotor symptoms, such as visual-spatial difficulties and dementia, focus on symptom management and continue to remain elusive. Therefore, understanding the molecular mechanisms behind these nonmotor symptoms is essential for the development of effective therapeutics leading to slower disease progression. The work presented in this dissertation sought to …
O-Glcnacylation And Modulation Of Gabaergic Transmission, Shekinah Phillips
O-Glcnacylation And Modulation Of Gabaergic Transmission, Shekinah Phillips
All ETDs from UAB
Changes in the strength of GABAergic transmission is heavily influenced by posttranslational modifications and allosteric modulators like benzodiazepines and neurosteroids. O-GlcNAcylation (O-GlcNAc) is a post-translational modification that is tightly regulated by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), which add or remove the O-GlcNAc moiety of β–N-acetylglucosamine to serine and threonine residues on proteins, respectively. Published reports from our lab have demonstrated that an acute increase in O-GlcNAcylation induces a long-term depression (LTD) of evoked GABAAR mediated IPSCs (eIPSCs) and reduces the amplitude and frequency of spontaneous IPSC (sIPSC) in hippocampal principal cells, however the mechanism in which this occurs is …
Clinical Practice And Perspectives On Addressing Biomechanical Maladaptations After Anterior Cruciate Ligament Reconstruction And A Potential Novel Solution, Kyle Southall
All ETDs from UAB
Gait is one of the most daily cyclic events an otherwise healthy human will experience. After an orthopedic injury such as an anterior cruciate ligament (ACL) injury that is commonly reconstructed (ACLR), gait can be largely affected, both acutely after injury, and long-term affecting the long-term knee health of the individual. As those individuals who sustain an ACL injury and subsequent reconstruction are commonly young, typically in their teens to early 30 years of age, the long-term effects of an ACLR procedure can have decades of impact on their respective quality of life. This dissertation used a variety of experimental …
The Effects Of Acute Beetroot Juice Intake On Glycemic And Blood Pressure Responses When Controlling For Medication In Individuals With Type 2 Diabetes, Andrew Tyler
All ETDs from UAB
The prevalence of cardiometabolic diseases has continued to rise within the United. Physical activity and poor dietary choices are two factors that are known to contribute to the rise in cardiometabolic diseases. Thus, it is critical to identify strategies that may mitigate the negative impact from these behaviors. Several recent studies have shown that consumption of dietary inorganic nitrate (diNO3) may improve vascular health and glucose regulation in animal models and some human studies. However, the improvements in glucose regulation have yet to be corroborated in humans with type 2 diabetes (T2D). Thus, the purpose of this study was to …
Elementary Cone Photoreceptor Signals In V1 Neurons, Cyril Nyankerh
Elementary Cone Photoreceptor Signals In V1 Neurons, Cyril Nyankerh
All ETDs from UAB
Daylight vision is initiated by the activation of cone photoreceptors in the retina in response to light, thereby generating spatial and temporal patterns of photoreceptor signals. Subsequent to this, the signals are combined and processed in downstream neural circuits, ultimately contributing to the formation of receptive fields of neurons in primary visual cortex (V1). Recent advances in adaptive optics (AO) have enabled imaging of the retina with near diffraction limited resolution, allowing for the probing of the visual system's processing at the resolution of individual cones. The central theme of this dissertation characterizes quantitively and qualitatively the physiological responses of …
Prenatally-Derived Macrophages Regulate Choroidal Health And Are Depleted In Age-Related Macular Degeneration, Seth Daniel Fortmann
Prenatally-Derived Macrophages Regulate Choroidal Health And Are Depleted In Age-Related Macular Degeneration, Seth Daniel Fortmann
All ETDs from UAB
The ocular choroid is the pigmented vascular bed that lies immediately deep to the retinal pigmented epithelium (RPE). The principal function of the choroid is to supply the photoreceptors with oxygen and nutrients and to remove waste products from the outer retina. In age-related macular degeneration (AMD), the choroid is dysfunctional as evidenced by hallmark histopathological findings including accumulation of extracellular lipid and vasodegeneration of the choriocapillaris. How and why the choroid fails in AMD remains incompletely understood. To this end, much attention has been paid to the RPE and endothelium but less is known about the contributions of other …
The T Cell Response In A Mouse Model Of Multiple System Atrophy, Nicole Jane Corbin-Stein
The T Cell Response In A Mouse Model Of Multiple System Atrophy, Nicole Jane Corbin-Stein
All ETDs from UAB
Multiple System Atrophy (MSA) is a fatal and rare demyelinating synucleinopathy, characterized by the accumulation of alpha-synuclein (α-syn) in glial cytoplasmic inclusions (GCIs) within oligodendrocytes. This condition is marked by neuroinflammation, demyelination, and neurodegeneration in areas showing GCI pathology, involving antigen presentation by myeloid cells and infiltration of CD4+ and CD8+ T cells. Despite strong evidence of neuroinflammation in post-mortem MSA tissue, the specific mechanisms driving the disease pathogenesis remain elusive. In prior research using the Olig001-SYN mouse model, which involves the modified AAV vector, it was shown that depleting CD4+ T cells can reduce neuroinflammation and demyelination. Notably, this …
Testicular Phenotypes Of Rdhe Dko Mice, Aja Slay
Testicular Phenotypes Of Rdhe Dko Mice, Aja Slay
All ETDs from UAB
The bioactive form of vitamin A, all-trans-retinoic acid (RA), plays a critical role in cell differentiation, metabolism, and cellular proliferation by regulating gene transcription. RA signaling is critical during embryogenesis to ensure proper development and during adulthood for tissue maintenance. Disruption of the RA signaling pathway induced by vitamin A deficiency and genetic defects in vitamin A metabolizing enzymes results in embryonic malformations. Previous studies implicate the short-chain dehydrogenase/reductase (SDR) family members as important in RA synthesis. Among the SDR family are retinol dehydrogenase epidermal 2 (RDHE2) and RDHE2-similar (RDHE2S)- collectively RDHE. To gain insight into how RDHE influences the …
Hope In Hyperbaric Medicine: A New Approach To Treat Neurological Injury, Lucas Andrew Lowe
Hope In Hyperbaric Medicine: A New Approach To Treat Neurological Injury, Lucas Andrew Lowe
All ETDs from UAB
Hyperbaric oxygen therapy (HBOT) has emerged as a promising adjunctive treatment approach for various neurological diseases. This literature review explores the role of HBOT in the treatment of spinal cord injuries. The review discusses the mechanisms of action by which HBOT exerts its effects on neural tissues, such as oxygen delivery, anti-inflammatory actions and neuroprotection. The analysis also highlights the findings from cellular biology, animal studies and clinical trials, offering insights into the potential benefits of HBOT in improving neurological injury outcomes and enhancing patients' quality of life. Furthermore, it addresses the safety considerations and guidelines for the application of …
Investigation On The Epigenetic Mechanisms Modified By Dietary Phytochemicals In Inhibiting Mammary Cancer, Mohammad Mijanur Rahman
Investigation On The Epigenetic Mechanisms Modified By Dietary Phytochemicals In Inhibiting Mammary Cancer, Mohammad Mijanur Rahman
All ETDs from UAB
Breast cancer (BC) is global burden for the health of women. It is the most commonly diagnosed cancer in women and the second leading cause of cancer mortality among women in the United States. One in every eight women in the USA has a chance of developing invasive BC in her lifetime. The limitations of the available therapeutics for BC treatment have brought the dietary prevention of BC to the attention of the scientific community as a safe, natural, and easy to implement therapeutic strategy. In this regard, our laboratory with many other laboratories have demonstrated the anti-BC effect of …
Promoting Endogenous Cardiomyocyte Proliferation In Large Mammal Hearts Via Cell Transfer Therapy Or Apical Resection: Understanding The Underlying Mechanism, Yuhua Wei
All ETDs from UAB
Cardiovascular diseases are the leading causes of global death. Due to the limit regenerative capacities of adult mammalian cardiomyocytes (CMs), myocardium is repaired with non-contractile fibrotic scar after a myocardial infarction (MI). Various strategies, including apical resection (AR) and cardiac cell therapy, are being explored to promote heart regeneration after MI. This dissertation research aimed to identify proliferating pig CM population after AR and understand the underlying mechanism of human induced pluripotent stem cells (hiPSCs) derived CMs (hiPSC-CMs) implantation for regenerating the pig hearts after MI. Our previous study showed that AR prolonged the heart regeneration window to postnatal day-28 …
Everyday Functioning In Middle Aged And Older Adults With Hiv: Factors That Influence Everyday Functioning And Awareness Of Functioning, Alexandra Elaine Jacob
Everyday Functioning In Middle Aged And Older Adults With Hiv: Factors That Influence Everyday Functioning And Awareness Of Functioning, Alexandra Elaine Jacob
All ETDs from UAB
With combination antiretroviral therapy (cART), the population of older people living with HIV (PLWH) is growing. There is a need to better understand everyday functioning, including instrumental activities of daily living (IADLs), to improve real-world outcomes for this clinical population. This dissertation attempts to (1) characterize factors related to self-report and performance of IADLs in PLWH, (2) examine correlates of self-awareness for functional abilities, and (3) apply a theoretical model to examine complex relationships between factors that impact self-awareness for functional abilities. Participants in these retrospective analyses included 260 PLWH who completed a comprehensive neurobehavioral evaluation including neuropsychological tests, measures …
Reduced Order Modeling (Rom) Using Machine Learning Techniques For Analyzing Fluid Flow Around A Ground Vehicle, Emmanuel Ong'aro Ramogi
Reduced Order Modeling (Rom) Using Machine Learning Techniques For Analyzing Fluid Flow Around A Ground Vehicle, Emmanuel Ong'aro Ramogi
All ETDs from UAB
Predicting wind and temperature fields around military vehicles during extended missions is crucial to avoid detectability by infrared (IR) devices. Also, the abrupt shifting of wind direction can have a significant impact on vehicle stability. This is a challenging task due to the vehicles' geometric complexity and the unpredictable nature of wind direction, which can shift abruptly. Computational Fluid Dynamics (CFD) is routinely used for calculating the flow fields around ground vehicles. However, this requires extensive computational time and memory, making it unsuitable for real-time analysis. To address these challenges, this research focuses on machine learning (ML) techniques for accurate …