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Combination Of 64/67cu Theranostics And Immunotherapy Targeting Fibroblast Activation Protein In Triple Negative Breast Cancer, Fnu Sharmila Sridhar
Combination Of 64/67cu Theranostics And Immunotherapy Targeting Fibroblast Activation Protein In Triple Negative Breast Cancer, Fnu Sharmila Sridhar
All ETDs from UAB
Triple negative breast cancer (TNBC) makes up 10-20% of breast cancer cases. Even with advancements in science, TNBC is treatment resistant due to the lack of any type of hormonal receptors on the cell surface making it difficult for targeted hormonal therapy. New research avenues have led to studies of the Tumor-microenvironment (TME) in detail. TME is a complex network of stromal cells, extracellular matrix (ECM) and cancer associated fibroblasts (CAFs) with pro-tumorigenic properties and plays a major role in tumor growth. Fibroblast activation protein (FAP) is a marker of CAF and promotes ECM remodeling through several pathways and has …
Determination Of Readthrough Susceptibility Among Different Schwann Cell Lines Carrying Nonsense Mutations, Trushali Vansadia
Determination Of Readthrough Susceptibility Among Different Schwann Cell Lines Carrying Nonsense Mutations, Trushali Vansadia
All ETDs from UAB
Neurofibromatosis Type 1 (NF1) is a genetic disorder that affects the nervous system through the formation of tumors or neurofibromas. Encoded by the NF1 gene, neurofibromin functions as a tumor suppressor by converting active GTP-Ras to inactive GDP-Ras. 20% of NF1 patients carry a genomic nonsense mutation, which generates a premature termination codon (PTC) in the NF1 mRNA, leading to the formation of a truncated neurofibromin protein. Termination at PTCs can be suppressed by the incorporation of an amino acid at the site of the PTC, also known as readthrough. Readthrough results in continued translation elongation downstream of the PTC …
Disruption Of Cochlear Development By Murine Cytomegalovirus Infection And Therapeutic Approaches That Prevent Hearing Loss, Matthew Smith
Disruption Of Cochlear Development By Murine Cytomegalovirus Infection And Therapeutic Approaches That Prevent Hearing Loss, Matthew Smith
All ETDs from UAB
Human cytomegalovirus (HCMV) is a ubiquitous virus, infecting greater than 50% of most populations worldwide. Although rarely causing symptomatic infection in immunocompetent individuals, HCMV can cause life-threatening and severe end-organ disease in immunocompromised hosts including the developing fetus. HCMV can cross the placenta and is the most common viral infection of the developing fetus. Most newborn infants with congenital HCMV infection (cCMV) exhibit no clinical evidence of infection; however, up to 15% will develop long term neurodevelopmental sequelae including sensorineural hearing loss (SNHL). No prophylactic vaccines or effective antiviral treatments exist for cCMV infection, which may in part be secondary …
Pseudomonas Aeruginosa And Tobramycin Effects On Aspergillus Fumigatus Infection In Cystic Fibrosis Airway, Tuan Anh Nguyen
Pseudomonas Aeruginosa And Tobramycin Effects On Aspergillus Fumigatus Infection In Cystic Fibrosis Airway, Tuan Anh Nguyen
All ETDs from UAB
Aspergillus fumigatus (Af) is one of the most common molds in the airways of people with Cystic Fibrosis (pwCF). The infection of Af is often preceded by Pseudomonas aeruginosa (PsA) infection and its correlated treatment. PsA is considered a highly prevalent bacteria in the CF lung. PwCF suffers from complex and sophisticated coinfections within the airway that negatively impact the health outcomes of patients. Despite this, why fungal and bacterial coinfection occurs in pwCF is still being determined. However, abnormal mucus production and its characteristics are suspected of creating an environment that promotes Af germination and disease progression. This study …
Surface-Engineered Nano/Micro-Hybrid Polymer Systems For Environmental Health And Safety, Renjith Rajan Pillai
Surface-Engineered Nano/Micro-Hybrid Polymer Systems For Environmental Health And Safety, Renjith Rajan Pillai
All ETDs from UAB
Environmental pollution involves the introduction of harmful substances into the natural environment, leading to detrimental effects on ecosystems, wildlife, and human health. This dissertation aims to advance comprehension of environmental pollution and explore efficient, environmentally friendly, and cost-effective methods of remediation. Recently, there has been increasing concern about the environmental impact of Polycyclic Aromatic Hydrocarbons (PAHs), a subgroup of Volatile Organic Compounds (VOCs), and Heavy Metals (HMs) pollution, both known for their carcinogenic and mutagenic properties. These pollutants can significantly harm human health through inhalation, ingestion, or contact with contaminated soil, potentially resulting in conditions such as encephalopathy, kidney dysfunction, …
A Histone Methyltransferase Contributes To Treatment Resistance In Npm1c Aml, Neha Srinivas
A Histone Methyltransferase Contributes To Treatment Resistance In Npm1c Aml, Neha Srinivas
All ETDs from UAB
Acute myeloid leukemia (AML) is a blood cancer marked by the rapid growth of abnormal myeloid cells, driven by various genetic mutations. AML accounts for approximately 1% of all cancers and presents complicated prognosis and treatment. Menin inhibitors have shown potential in targeting AML. However, resistance to these inhibitors presents a significant clinical obstacle, as patients treated with menin inhibitors are increasingly developing resistance to the treatment. Using CRISPR-Cas9 mediated screening, we identified an epigenetic regulator contributing to resistance against menin inhibitors in AML. Utilizing knockout (KO) models of the epigenetic regulator in-vitro, ex-vivo, and in-vivo, we observed a growth …
Improving Molecular Diagnosis Success Rates And Prognosis Prediction For Patients With Rare Diseases, Tarun Karthik Kumar Mamidi
Improving Molecular Diagnosis Success Rates And Prognosis Prediction For Patients With Rare Diseases, Tarun Karthik Kumar Mamidi
All ETDs from UAB
Rare diseases are medical conditions that affect a small number of people compared to the general population. There are more than 10,000 estimated rare diseases with 80% being genetic in origin, which although individually have a relatively low prevalence, collectively impact the lives of hundreds of millions of people worldwide. The diagnosis process is usually difficult and slow, but an accurate and early diagnosis can be crucial for disease treatment and management. This dissertation focuses on some of the important problems in this area by investigating the application of advanced machine learning methods to enhance the accuracy, precision, and efficiency …
Investigating The Impacts Of Staphylococcus Aureus Small Colony Variant Infection In The Cystic Fibrosis Rat Lung, Gretchen E. Bollar
Investigating The Impacts Of Staphylococcus Aureus Small Colony Variant Infection In The Cystic Fibrosis Rat Lung, Gretchen E. Bollar
All ETDs from UAB
Cystic fibrosis (CF) is an autosomal-recessive genetic disease characterized by recurrent and chronic airway infections. Staphylococcus aureus is currently the most common organism isolated from the CF lung, but its role as a pathogen has been historically difficult to characterize due to a broad range of genetic diversity and subtypes seen across infectious strains. Small colony variants (SCVs) are a subpopulation of S. aureus marked by slow growth rate and impaired metabolism that have been associated with worse respiratory outcomes in people with CF (pwCF). SCVs also exhibit altered colony morphology and can confound the results of traditional diagnostic assays, …
A Visual Guide To Balancing Latency And Bandwidth In Mpi All-To-All, Naeris Netterville
A Visual Guide To Balancing Latency And Bandwidth In Mpi All-To-All, Naeris Netterville
All ETDs from UAB
The complex nature of parallel algorithms in the Message Passing Interface (MPI) standard challenges the ability of trivially visualizing them. Within MPI libaries (e.g., MPICH, Open-MPI), there are many collectives that offer different solutions for communicating data between processes. The collective MPI_Alltoall uses various techniques such as the spread-out and Bruck algorithms to have processes transfer data between all processes. Each technique within MPI_Alltoall is best suited for different scenarios. The spread-out algorithm uses a linear number of iterations, in process count P, while the Bruck algorithm is logarithmic. The Bruck algorithm transfers more data overall, but with fewer communication …
Cardiomyocyte-Specific Modified Mrna For Myocardial Regeneration In A Porcine Myocardial Infarction Model, Jiacheng Sun
Cardiomyocyte-Specific Modified Mrna For Myocardial Regeneration In A Porcine Myocardial Infarction Model, Jiacheng Sun
All ETDs from UAB
The inability of adult mammalian cardiomyocytes (CMs) to undergo cell renewal following ischemic injury stands as a major impediment to heart function recovery and contributes to heart failure (HF). Current therapeutic approaches do not offer an effective approach of reactivating CM cell division to prevent HF in humans. Recognizing this challenge, gene therapy has emerged as a promising approach to promote CM proliferation and enhance cardiac repair. A particularly notable approach is the utilization of modified mRNA (modRNA), which provides a safe, controlled, transient, non-viral, and clinically relevant means of gene delivery. The study was conducted using a novel cardiomyocyte …
Investigating The Electrostatics Of Mucins As Key Contributors To Mucus Stasis In Cystic Fibrosis, Elex Skylar Rose
Investigating The Electrostatics Of Mucins As Key Contributors To Mucus Stasis In Cystic Fibrosis, Elex Skylar Rose
All ETDs from UAB
Cystic fibrosis (CF) is a genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which encodes a channel responsible for the transport of chloride and bicarbonate ions across the apical cell surface. In the respiratory tract, defective CFTR results in viscous and adherent mucus that becomes static within the airway, which leads to chronic infections, progressive lung damage, and early mortality. Historically, CF mucus stasis has been attributed to significant airway dehydration; however, growing evidence has demonstrated that aberrant electrostatic properties of mucins also contribute to mucus stasis in CF. Mucins are large, polymeric glycoproteins …
Electromechanical Mapping Of The In Vivo Porcine Heart And Stomach, Haley Nesmith Patton
Electromechanical Mapping Of The In Vivo Porcine Heart And Stomach, Haley Nesmith Patton
All ETDs from UAB
Electrical excitation and mechanical function are integral to the physiologic activity of both the heart and stomach. Electrical depolarization through the myocardium triggers contraction in the heart. When normal sequences of electrical activity are disturbed, the heart’s mechanical function may also be disturbed, affecting its ability to pump blood effectively, sometimes fatally. Similarly, electrical waves called slow waves initiate gastric peristalsis. Abnormalities in slow wave propagation patterns can disturb the stomach’s ability to mechanically process gastric contents, sometimes resulting in delayed gastric emptying, nausea, and vomiting. The relationship between mechanical function and electrophysiology is not unidirectional, though. Mechanical stimuli can …
The Role Of Fibroblast Growth Factor Receptors In Inflammatory Airway Diseases, Molly Easter
The Role Of Fibroblast Growth Factor Receptors In Inflammatory Airway Diseases, Molly Easter
All ETDs from UAB
Chronic inflammation plays a role in the development and progression of airway diseases such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). COPD is caused primarily by chronic cigarette smoke exposure. Conversely, CF is a single gene disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR). Although the causes of COPD and CF are different, there are common pathological features. Studies show that chronic inflammation plays a significant role in the pathogenesis of both COPD and CF. Moreover, chronic inflammation induces ageing-associated pathomechanisms like cellular senescence, which exacerbates chronic inflammation. Previous work demonstrates that …
Genotype And Sex Specific Effects Of Methionine Restriction On The Life And Healthspan Of Drosophila Melanogaster, Joshua Robert Smith
Genotype And Sex Specific Effects Of Methionine Restriction On The Life And Healthspan Of Drosophila Melanogaster, Joshua Robert Smith
All ETDs from UAB
Reduced dietary intake of the amino acid methionine has been reported to significantly extend the lifespan of common laboratory model organisms including Saccharomyces cerevisiae, Mus musculus, and Drosophila melanogaster. Methionine restriction (MR) has also been achieved via non-dietary means such as metabolite supplementation and CRISPR-Cas9 gene editing. MR along with protein and calorie restriction are known as dietary interventions capable of producing pro-longevity benefits through regulation of nutrient sensing pathways. Recent studies in model organisms have also identified beneficial effects of a low methionine diet on aging-associated phenotypes and markers of overall healthspan. However, the effects of this intervention on …
Characterizing The Reproductive System Of Avrainvillea In HawaiʻI, Brinkley Mikayla Thornton
Characterizing The Reproductive System Of Avrainvillea In HawaiʻI, Brinkley Mikayla Thornton
All ETDs from UAB
Sex has generated incredible life cycle diversity across eukaryotes. Differences in the timing of meiosis and fertilization have generated tremendous variation in the duration of haploid and diploid phases. To understand what drives eukaryotic sexual diversity, there remains a need to determine the rates of sexual and asexual reproduction in natural populations. Moreover, life cycle diversity is predicted to be correlated with the reproductive system. Yet, most studies on reproductive variation have focused on diploid or diploid dominant organisms, hindering the ability to understand sex. Macroalgae can serve as useful models to overcome this limitation via life cycle and reproductive …
The Impact Of O-Glcnac Signaling On Dna Hydroxymethylation In Temporal Lobe Epilepsy, Rudhab Bahabry
The Impact Of O-Glcnac Signaling On Dna Hydroxymethylation In Temporal Lobe Epilepsy, Rudhab Bahabry
All ETDs from UAB
Temporal Lobe Epilepsy (TLE) is the most prevalent form of focal epilepsy and the most treatment-resistant type. This condition is characterized by recurrent, unprovoked seizures typically originating in the hippocampus. Epigenetic modifications such as DNAme changes have been implicated in brain functions such as synaptic plasticity, learning and, memory, and cognition. The oxidation of DNA 5-methylcytosine (5-mC) and its oxidized form, 5-hydroxymethylcytosine (5-hmC) catalyzed by Ten-Eleven Translocation (TET) family of dioxygenases and linked to epilepsy's hyperexcitable state. Post‐translational modifications (PTMs) of proteins, such as O-GlcNAcylation, facilitate cells' immediate responses to intracellular or extracellular environmental stimuli by modifying the functions of …
Evaluation Of Feed Intake, Growth, And Reproduction In The Zebrafish, Danio Rerio, Fed A Gel-Based Diet, Thomas Logan Holfelder
Evaluation Of Feed Intake, Growth, And Reproduction In The Zebrafish, Danio Rerio, Fed A Gel-Based Diet, Thomas Logan Holfelder
All ETDs from UAB
EVALUATION OF FEED INTAKE, GROWTH, AND REPRODUCTION IN THE ZEBRAFISH, DANIO RERIO, FED A GEL-BASED DIET THOMAS LOGAN HOLFELDER BIOLOGY ABSTRACT The zebrafish, Danio rerio, is a valuable pre-clinical model, aiding human health understanding and translational aquaculture. Comprehensive documentation of the culture of this model exists, with ongoing efforts to optimize husbandry requirements, particularly in the areas of diet and nutrition. Labor or mechanical costs related to feeding are high in most laboratories and alternative protocols to reduce feed handling would be beneficial and could allow the capability to monitor feed consumption. A commercially produced gel-based diet has a high …
Investigating Hiv-1 Transmission To Human Cervix Using Reporter Virus Technologies, Dana Frances Indihar
Investigating Hiv-1 Transmission To Human Cervix Using Reporter Virus Technologies, Dana Frances Indihar
All ETDs from UAB
Around 39 million people globally are currently infected with Human immunodeficiency virus 1 (HIV-1), more than half of whom are women. HIV-1 is a retrovirus that infects and depletes an individual’s immune cells, culminating in the development of acquired immunodeficiency syndrome (AIDS) if not managed with anti-retroviral therapies (ART). Most women acquire HIV-1 through heterosexual intercourse. However, the early mechanisms and virologic determinants of HIV-1 transmission to women remain unclear. Herein, we demonstrate transmitted/founder (TF) HIV-1 representing two genetically and pathogenically distinct subtypes (A and D) in vivo have distinct replication phenotypes in an ex vivo cervical explant tissue (CET) …
The Role Of Altered Cell-Cell Communication Between Glia And Neurons In Alzheimer’S Disease, Tabea Marga Soelter
The Role Of Altered Cell-Cell Communication Between Glia And Neurons In Alzheimer’S Disease, Tabea Marga Soelter
All ETDs from UAB
Alzheimer’s disease is the most prevalent neurodegenerative disease and is characterized by progressive memory loss and cognitive decline, affecting behavior, speech, and motor abilities. The neuropathology includes the formation of extracellular amyloid-β plaques and intracellular neurofibrillary tangles of phosphorylated tau. Additionally, neurons become functionally impaired before degenerating and dying. While neuronal loss is a disease hallmark, glia maintain neuronal health and homeostasis through cell-cell communication with neurons. Cellular crosstalk is mediated through the release of chemical intermediates (i.e., ligands), which are taken up by cell surface membrane receptors. Previous studies have shown dysregulation of global cell-cell communication patterns and communication …
Optical Absorption Of Defects In Aluminum Nitride, Mackenzie Siford
Optical Absorption Of Defects In Aluminum Nitride, Mackenzie Siford
All ETDs from UAB
Aluminum nitride (AlN) is an ultrawide bandgap semiconductor material known for its applications in high power microelectronic and optoelectronic devices due to its high thermal conductivity and high electrical resistivity. Point defects are known to hinder the material’s properties and are therefore a subject of interest in semiconductor materials research. The samples used in this work were grown by physical vapor transport (PVT) at Hexatech and they exhibit amber and clear coloration as well as a nonuniformity of charge, which was investigated. Experiments were carried out by electron paramagnetic resonance (EPR) and photo-EPR spectroscopy in order to detect the defect …
Exploring The Associations Between Cognitive Training, Social Determinants Of Health, And Driving Behaviors: A Longitudinal Analysis Of The Active Study, Katie Wheeler
All ETDs from UAB
As the average lifespan increases, older adults are remaining independent into older ages than before. The ability to drive a vehicle is an essential part of daily living that helps older adults maintain independence. Cognitive training, specifically speed of processing training (SOPT), is an intervention that has consistently shown to benefit older adult’s driving abilities and driving behaviors. This dissertation examined the longitudinal association between cognitive training and primary driving location on crash risk across 20 years (Paper 1), investigated the effects of cognitive training and dosage on driving mobility across 10 years (Paper 2), and explored social determinants of …
The Modification Of Single Domain Antibody Framework And Variable Regions To Impart Novel Pharmacodynamic And Pharmacokinetic Properties, Lucinda Ann Hall
The Modification Of Single Domain Antibody Framework And Variable Regions To Impart Novel Pharmacodynamic And Pharmacokinetic Properties, Lucinda Ann Hall
All ETDs from UAB
In recent years, nanobodies have become important theranostic molecules, and research has focused on improving their pharmacokinetics and binding for novel targets. Nanobodies are characterized by their high kidney uptake, leading to potentially unsafe exposure of the kidneys when delivering cytotoxic payloads. Researchers hypothesize that positively charged amino acids contribute to this kidney uptake. To address this, we assessed the impact of substituting lysine residues within the 2Rs15d HER2 nanobody scaffold to alanine on its in vivo pharmacokinetics using positron emission tomography (PET) imaging. We found that nanobodies bearing lysine-to-alanine substitutions maintained their affinity for HER2. Characterization of the K88A …
Use Of Psilocybin And Other Classic Psychedelics In Fibromyalgia: A Survey Study, Kathleen Hodgin
Use Of Psilocybin And Other Classic Psychedelics In Fibromyalgia: A Survey Study, Kathleen Hodgin
All ETDs from UAB
Psilocybin and other classic psychedelics may have potential for treatment of fibromyalgia, a chronic condition characterized by widespread musculoskeletal pain and other symptoms including fatigue, cognitive difficulties, and sleep problems. In this exploratory, descriptive study, an online survey was distributed among individuals with fibromyalgia to gather reports of any changes in pain related to past classic psychedelic use. Sixty-four participants with fibromyalgia completed the study, with most having used psilocybin mushrooms or LSD. In addition to recreational use and other reasons, use of psychedelics for mental health or pain-related reasons was frequently endorsed. Of the participants who reported experiencing any …
Non-Catalytic Regulators Of The Secretory Pathway, Peyton Vanwinkle
Non-Catalytic Regulators Of The Secretory Pathway, Peyton Vanwinkle
All ETDs from UAB
This thesis focuses on two key questions: 1) how are bone development and regeneration regulated by the CREB3L1 transcription factor; and 2) what is the mechanism of action of the endoplasmic reticulum resident protein JAGN1, which when dysregulated, causes severe congenital neutropenia (SCN)? CREB3L1 regulates bone development and regeneration in mammalian models by facilitating the expression of COL1A1 and components of the secretory pathway required for collagen secretion. We generated two zebrafish models of Creb3l1 dysfunction (creb3l1ΔbZIP/ΔbZIP and creb3l1TA+/TA+). Both models showed that Creb3l1 functions in regulating col1a1a transcription and overall regenerate size are conserved in zebrafish. However, we also …
Knocking At The Door: The Life And Legacy Of Dr. James Montgomery, Haley Eloise Wells
Knocking At The Door: The Life And Legacy Of Dr. James Montgomery, Haley Eloise Wells
All ETDs from UAB
The life and work of Black Birmingham cardiologist, Dr. James T. Montgomery, demonstrates the importance of viewing the history of health activism and Birmingham civil rights history as two interconnected histories that influenced each other. Traditionally, secondary scholarship on the Birmingham civil rights movement and scholarship on the history of healthcare have been treated as two separate areas of study. Scholars such as Glenn Eskew and Diane McWhorter have written extensively on the civil rights movement in Birmingham, but their scholarship excludes any comprehensive discussion of the fight for racial justice within Birmingham’s medical field. Conversely, scholars such as Thomas …
Physiologically Relevant Cardiac Tissue Chips For Cardiovascular Disease Modeling, Sachin Budhathoki
Physiologically Relevant Cardiac Tissue Chips For Cardiovascular Disease Modeling, Sachin Budhathoki
All ETDs from UAB
Despite significant advances in our understanding of the molecular basis of cardiovascular diseases (CVD) and the development of new therapeutics, it remains the number one cause of death worldwide, particularly affecting the aging population. This necessitates the development of models that can more accurately recreate aspects of aging and the interaction of the heart with other organs and systems in the body, including the immune system. Tissue chip models are being increasingly considered for studying cardiac diseases as they can potentially address translational hurdles associated with animal models, yet several challenges hinder their full potential. These include a lack of …
Diagnostic Imaging Approaches: Pet Imaging In Monitoring Immune Responses In Oncology And Tuberculosis, Chanelle Hunter
Diagnostic Imaging Approaches: Pet Imaging In Monitoring Immune Responses In Oncology And Tuberculosis, Chanelle Hunter
All ETDs from UAB
Positron emission tomography (PET) imaging agents play a transformative role in personalized medicine through their application in disease diagnosis and immunotherapy monitoring, focusing on chemokine receptors, TH1-activated immune cells, and tuberculosis (TB) diagnostics. In immuno-oncology, accurately assessing TH1-activated immune cells in the tumor microenvironment (TME) is vital for evaluating cancer immunotherapy efficacy. Chemokine receptors, crucial in cellular signaling and inflammatory reactions, play a significant role in TH1 responses, thus serving as a potential area of interest in elucidating these anti-tumor responses. Through our work a novel CXCR3-targeting immunoPET probe, [89Zr]DFO-αCXCR3, was developed to detect and quantify these cells. This probe …
Titanium-45 Radiochemistry For The Development Of Pet Radiopharmaceuticals, Fnu Shefali
Titanium-45 Radiochemistry For The Development Of Pet Radiopharmaceuticals, Fnu Shefali
All ETDs from UAB
Imaging using nuclear medicine techniques has enabled non-invasive measurements of biomarkers for a wide range of diseases including cancer and neurodegenerative disorders. The production and characterization of new radioisotopes are crucial steps in designing radiopharmaceuticals for nuclear imaging applications. 45Ti is a novel radionuclide with desired physical characteristics for use in Positron Emission Tomography (PET) imaging. The half-life of 3.08 h is ideal for the imaging of small peptides. In addition, the 45Ti decay by positron emission (85 %) and a low mean positron energy (0.439 MeV) offers high spatial resolution. The production route of 45Ti is straightforward due to …
[Mis]Representing “India” And Other Colonial Territories In Donne’S Poetry: An Insight Into Colonialism’S Multifaceted Aspects, Urnisha Dutta
[Mis]Representing “India” And Other Colonial Territories In Donne’S Poetry: An Insight Into Colonialism’S Multifaceted Aspects, Urnisha Dutta
All ETDs from UAB
Colonial objects in Donne’s poems embrace multifaceted attributes, offering diverse reading perspectives. Considering their multifaceted aspects, it becomes impossible for a reader to ignore his poems’ interdisciplinary qualities. They often embrace philosophical, religious, political, and historical connotations. The colonial objects, appearing as “black” characters, silent women, or colonized territories in his poems, generate East-West binaries, Western subject consciousness, Eastern [mis]representations, world polarizations, and color contrasts. His female bodies’ misogynistic/sexual portrayal frequently ends in pulling up colonial references, associating their bodies with colonial landmasses. They often associate with his spiritual consciousness, complicating reading and textual interpretations. Critics thus cannot take a …
3d Microtissue Model Of The Aged Ovarian Tumor Microenvironment, Peyton Clark
3d Microtissue Model Of The Aged Ovarian Tumor Microenvironment, Peyton Clark
All ETDs from UAB
Ovarian cancer is the 5th leading cause of cancer deaths for women, primarily due to treatment resistant and/or recurrent disease. Most cases of ovarian cancer are not diagnosed until distant metastases have formed, which drastically reduces overall survival. The median age at diagnosis is 63 and most cases occur in patients who are peri- and post-menopausal. There is a critical gap between the clinical presentation of ovarian cancer and the preclinical models used to study the disease. Most preclinical in vivo investigations use mice who are between 6 and 12 weeks old, which corresponds to roughly a 20-year-old human. Therefore, …