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Diurnal Function And Expression Of Aquaporins In The Mouse Kidney, Phi Hung Nguyen
Diurnal Function And Expression Of Aquaporins In The Mouse Kidney, Phi Hung Nguyen
All ETDs from UAB
Aquaporins (AQPs) are a family of proteins that play a major role in maintaining water homeostasis. Aquaporin 2 (AQP2) and aquaporin 3 (AQP3) are expressed in the collecting duct and regulated by the antidiuretic hormone arginine vasopressin (AVP) through the AVPR2 receptor. It is well known that biological circadian rhythms are critical for maintaining homeostasis. In both humans and rodents, the kidneys exhibit time-of-day-dependent changes in function. We hypothesized that there is a diurnal pattern in urine and/or plasma osmolality, and that this may reflect changes in kidney aquaporins in mice. Male and female C57BL/6J mice (10-11 weeks old) were …
Increasing The Knowledge, Awareness, And Readiness To Change Of Cultural Sensitivity Among Public Health College Students, Margaret Enlow
Increasing The Knowledge, Awareness, And Readiness To Change Of Cultural Sensitivity Among Public Health College Students, Margaret Enlow
All ETDs from UAB
This research examined if a lecture-based intervention increased the DEI knowledge, awareness, and readiness to change in undergraduate public health students. Topics included a systematic review of DEI activities in undergraduate public health classrooms/academic programs, determining reliability of an adapted tool to measure knowledge, awareness, and readiness to change, and statistical analyses of pre- and post-data to determine knowledge, awareness, and readiness to change after students participated in the lecture-based intervention. The systematic review identified a gap in the literature regarding public health DEI education in the classroom. Through additional analyses, themes of DEI were identified in previous publications that …
Point-Of-Care Portable Perfusion Phantom For Accurate Dce-Mri Measurement, Martin Dawson Holland
Point-Of-Care Portable Perfusion Phantom For Accurate Dce-Mri Measurement, Martin Dawson Holland
All ETDs from UAB
Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) monitors the temporal changes in contrast agent concentration within human tissues to assess the pharmacokinetic parameters of that tissue. Traditionally, these scans are evaluated qualitatively, but quantitative DCE-MRI (qDCE) may improve patient care by enabling more objective and accurate data analysis. One significant challenge hindering the broader adoption of qDCE is the variability of data across different MRI machines. Each manufacturer employs unique hardware and software configurations, leading to inconsistencies in quantifying the contrast agent concentration in tissues and, consequently, the pharmacokinetic parameters. Even using the same scanner, measurements can drift due to hardware …
Social Dominance And Cortical Neuronal Synchrony In Male Mecp2 Knockout Mice, Cesar Andres Acevedo Triana
Social Dominance And Cortical Neuronal Synchrony In Male Mecp2 Knockout Mice, Cesar Andres Acevedo Triana
All ETDs from UAB
Social behaviors are critical for the survival of individuals, and their dysfunction is common in several neuropsychiatric and neurodevelopmental disorders including autism, where impaired sociability is one of the core diagnostic symptoms and compromises the interpretation of social cues, with an apparent lack of interest in others. Among the neurodevel opmental disorders associated with autism, Rett syndrome (RTT) is a disorder predominantly affecting females and caused by spontaneous loss-of-function mutations in the X-linked MECP2 gene, which encodes the transcriptional regulator MeCP2 that regulates many critical genes. RTT individuals have impaired motor, cognitive, and social abilities most of which are recapitulated …
Metabolic And Physiological Characteristics Of Diet Manipulation And Genetic Modification In Two Rat Models Of Aging, Soe Maung Maung Phone Myint
Metabolic And Physiological Characteristics Of Diet Manipulation And Genetic Modification In Two Rat Models Of Aging, Soe Maung Maung Phone Myint
All ETDs from UAB
As society and human civilization advances, humans have begun to live longer and most people live to be longer than 60, which was not the case several decades ago. According to the World Health Organization(WHO), by the turn of the next decade at 2030, 1 in 6 people will be 60 years or older, accounting for almost 1.4 billion people. Aging affects people differently but in general, it has a propensity to induce widespread and progressive molecular and cellular damage which leads to a myriad of diseases and eventually death. The greatest risk factor for most of the chronic diseases …
The Relationship Between Molten Iron Chemistry Of A Cupola Furnace And Airborne Contaminants, Darkeya D. Rowe
The Relationship Between Molten Iron Chemistry Of A Cupola Furnace And Airborne Contaminants, Darkeya D. Rowe
All ETDs from UAB
The purpose of this research was to understand the potential relationship between the molten iron chemistry of a cupola furnace and airborne contaminants. Three-day air sampling was performed for the emissions of a cupola furnace using 37 mm mixed cellulose ester (MCE) filter cassettes at an iron foundry. The samples were analyzed for 21 elements and compounds by a commercial laboratory using the modified National Institude for Occupational Safety and Health (NIOSH) Method 7303, most of which were metals. The concentrations of 13 out of 21 elements and compounds were compared to the corresponding elements in molten metal/iron stream analyzed …
Effects Of Whole-Food, Plant-Centered Diets On Glycemic Control, Medication Use, Ectopic Fat, And Cardiovascular Health In Adults With Type 2 Diabetes, Cody Hanick
All ETDs from UAB
Type 2 diabetes (T2D) is a global health and economic concern. Safe and effective treatments for T2D, including dietary approaches, are limited. Additionally, it remains unclear whether dietary carbohydrate quality or quantity matters more for managing T2D. Most nutrient-dense carbohydrate quality sources—such as fruit, vegetables, legumes, and whole grains—come from plant foods and are recommended for people with T2D by the American Diabetes Association. Furthermore, when these food groups are combined into a dietary pattern, a whole-food, plant-based (WFPB) diet is created. However, few studies have tested the effects of a WFPB diet or carbohydrate-rich food groups in people with …
From Portraits To Bathwater: Desire, Imitation, And Violence In The Picture Of Dorian Gray And Saltburn, Kylie Marie Golden
From Portraits To Bathwater: Desire, Imitation, And Violence In The Picture Of Dorian Gray And Saltburn, Kylie Marie Golden
All ETDs from UAB
This thesis examines the cycle of imitation within queer male desire in The Picture of Dorian Gray and Saltburn, arguing that both texts depict an unsustainable pattern in which protagonists mold themselves after an idealized other, leading to obsession, violence, and self-destruction. While Oscar Wilde’s novel encodes queerness within aestheticism and moral decay, Emerald Fennell’s film reconfigures these themes through class ambition and performative sexuality. I explore how both texts present imitation as a dangerous mechanism through which male characters construct their identities, only to find that their self-fashioning is ultimately untenable. This study positions Saltburn as a contemporary rewriting …
The Antiviral Treatment Of Bk Polyomavirus, Peter Alexander Kaul
The Antiviral Treatment Of Bk Polyomavirus, Peter Alexander Kaul
All ETDs from UAB
A kidney transplant is the most common form of organ transplant in the United States. The waitlist of patients waiting for a kidney transplant totals over 80,000. In recent years, kidney transplants have been performed more than ever before, but the waitlist continues to grow. This is due to the constant addition of new patients being added, as well as, patients who obtained a kidney transplant, but their transplant failed and were added back to the waitlist. While the development of more specific and effective immunosuppressive drugs given to transplant recipients have reduced the cases of acute rejection, it has …
An Examination Of Psycho-Behavioral Risk And Resilence Profiles In People With Chronically Painful Knee Osteoarthritis, Daniel Kusko
An Examination Of Psycho-Behavioral Risk And Resilence Profiles In People With Chronically Painful Knee Osteoarthritis, Daniel Kusko
All ETDs from UAB
The prevalence and impact of chronic pain are far-reaching and costly to our society. Chronic pain conditions are affecting many people in the US and abroad. Osteoarthritis (OA) is commonly referred to as a slow progressing degenerative disease that tends to develop over 10 to 15 years and can result in functional limitations and pain. Chronic knee OA is a common form of OA pain that affects many adults across the globe. Biopsychosocial factors are theorized to play an important role in how people with chronic pain may develop, exacerbate, or cope with pain. The goal of this project was …
Reelin Regulation Of Striatal Physiology And Cocaine Reward, Kasey Lynn Brida
Reelin Regulation Of Striatal Physiology And Cocaine Reward, Kasey Lynn Brida
All ETDs from UAB
Drugs of abuse activate defined neuronal populations in brain reward structures such as the nucleus accumbens (NAc), which are thought to promote the enduring synaptic, circuit, and behavioral consequences of drug exposure. While the molecular and cellular effects arising from experience with drugs like cocaine are increasingly well understood, the mechanisms that sculpt NAc neuron participation are largely unknown. Here, we leveraged unbiased single-nucleus transcriptional profiling to identify expression of the secreted glycoprotein Reelin (encoded by the Reln gene) as a marker of cocaine-activated neurons within the rat NAc. Multiplexed in situ detection confirmed selective expression of the immediate early …
Food Insecurity Among Graduate Students At The University Of Alabama At Birmingham, Amy Elizabeth Callahan
Food Insecurity Among Graduate Students At The University Of Alabama At Birmingham, Amy Elizabeth Callahan
All ETDs from UAB
College food insecurity (FI) has grown steadily as a field of research over the past fifteen years. Existing research primarily has demonstrated that FI is a persistent problem with various risk factors and myriad potential impacts on students, though graduate students are largely understudied in favor of undergraduate and aggregated student populations. Given the unique circumstances graduate students face, as well as expected demographic differences such as age and household characteristics, this is a serious gap in the literature. This dissertation aims to investigate graduate student food insecurity in the United States, and particularly at the University of Alabama at …
Elucidating The Proteolytic Determinants Of Flavivirus Infection, Lochlain C. Corliss
Elucidating The Proteolytic Determinants Of Flavivirus Infection, Lochlain C. Corliss
All ETDs from UAB
Flaviviruses, recently renamed to orthoflaviviruses, are small, enveloped viruses with positive-sense, single-stranded RNA (ssRNA) genomes of about 11 kilobases. Upon cell entry and uncoating, the viral RNA (vRNA) is directly translated at the endoplasmic reticulum (ER) as a single polyprotein that is then processed by the viral and cellular proteases into 10 functional subunits, consisting of three structural proteins and seven nonstructural (NS) proteins. Among the NS proteins are NS2B and NS3, which form the viral protease complex. NS3 consists of a serine protease domain while NS2B is anchored to the ER and contains a cytoplasmic loop that serves as …
Discarded People, Amber Harris
Discarded People, Amber Harris
All ETDs from UAB
ABSTRACT This is the first chapter of the novel, Discarded People, a character-driven story about a group of young Black friends navigating love, identity, and community. As they form deep connections with one another, they face personal struggles that challenge their sense of belonging and self-discovery. The narrative explores themes of family, friendship, and the search for purpose, while highlighting the complexities of building a chosen family amidst personal and societal pressures. In chapter one, the main characters are introduced; Winnie, Franklin, Jelani, Adanna, Eban and Chance. As the characters prepare for their final year in high school while navigating …
Stimulation And Quantification Of Dopamine-Associated Behaviors, Hunter Goffinett
Stimulation And Quantification Of Dopamine-Associated Behaviors, Hunter Goffinett
All ETDs from UAB
Dopamine (DA) is a neurotransmitter involved in the regulation of essential behaviors, including motor control and reward processing. Alterations in DA levels can significantly modulate these behaviors: increased DA release is associated with heightened locomotion and enhanced preference for rewarding stimuli. Therefore, measuring behavioral changes in vivo provides critical insight into DA release and function. In this study, we quantified DA-associated behaviors by radiolytic stimulation of the Drosophila A-isoform of the transient receptor potential ankyrin type-1 A (dTRPA1(A)) channel and investigated how the human-immunodeficiency virus (HIV) and its secreted protein, the trans-activator of transcription regulatory protein (Tat), alter drug-induced behaviors. …
Unveiling The Other: Feminine And Colonial Subjugation In Mary Elizabeth Braddon's England, Kaylie Rastegar
Unveiling The Other: Feminine And Colonial Subjugation In Mary Elizabeth Braddon's England, Kaylie Rastegar
All ETDs from UAB
Just a few years after England experienced major societal shifts, both domestically in the passage of revolutionary women’s rights legislation and internationally in the Indian Mutiny, Mary Elizabeth Braddon’s Lady Audley’s Secret (1862) offered Victorian readers a way to confront their anxieties and uncertainties about the nation’s future. The traditional power structures of British imperialism and patriarchy faced growing resistance as Indian rebels and women’s rights reformers challenged their assumed natural authority. Past scholarship contextualizes the novel within these major historical events, viewing them in relation to each other in which the struggles of Indian colonial subjects equate to those …
Mesenchymal Hippo Signaling In Lung Development And Disease, Kylie Klinkhammer
Mesenchymal Hippo Signaling In Lung Development And Disease, Kylie Klinkhammer
All ETDs from UAB
During both lung development and regeneration, the proper coordination of different cellular populations working in concert are vital to proper development and wound repairs. Myofibroblasts, highly contractile mesenchymal cells, are vital the organization of cells during lung development and to the remodeling of the extra cellular matrix (ECM) during regeneration. As important as myofibroblasts are, their apoptosis or differentiation to a less contractile phenotype is equally important to normal development and regenerative processes. Excessive differentiation of myofibroblasts or the improper localization of myofibroblasts are associated with pulmonary fibrosis, which is characteristic of lung disease, such as bronchopulmonary dysplasia or idiopathic …
Uncovering The Role Of Heparanase-Armed Extracellular Vesicles In Sepsis-Associated Vascular Endotheliopathy, Robert Patrick Richter
Uncovering The Role Of Heparanase-Armed Extracellular Vesicles In Sepsis-Associated Vascular Endotheliopathy, Robert Patrick Richter
All ETDs from UAB
Sepsis remains one of the most frequent causes of mortality and life-altering morbidity in humans of all ages globally. Though sepsis pathobiology is incompletely understood, it is clear that a unifying feature of all sepsis phenotypes is systemic vascular endotheliopathy and damage to the luminal glycocalyx of endothelial cells, or eGC, that leads to organ injury. While prior work has established that heparan sulfate (HS) is an especially important eGC constituent that helps regulate a host of endothelial cell (EC) functions, its role in promoting endotheliopathy during sepsis has not been fully characterized. Additionally, previous studies in the context of …
An In-Depth Review Of Food Insecurity In College Students Enrolled In Alabama Historically Black Colleges And Universities, Janice Dansby Washington
An In-Depth Review Of Food Insecurity In College Students Enrolled In Alabama Historically Black Colleges And Universities, Janice Dansby Washington
All ETDs from UAB
Food insecurity is a common issue in the United States (US), and special attention has been given to college students. There is empirical evidence of high food insecurity among African American students at Historically Black Colleges and Universities (HBCUs) (Duke et al., 2023; Dahl et al., 2022; Goldrick-Rab et al., 2018). The current research explores the food-insecure conditions of college students at HBCUs in Alabama, appealing for more studies highlighting the role of all stakeholders in combating this issue. The research questions posed in this study are significant, as they are expected to yield vital information regarding the experiences and …
Chronic Pain And Resilience: Associations And Interactions With Diet, Asia Wiggins
Chronic Pain And Resilience: Associations And Interactions With Diet, Asia Wiggins
All ETDs from UAB
Chronic pain is a significant issue globally, affecting millions of people. One relatively new way mechanism to reduce pain is to promote resilience. Yet, the effect of resilience on chronic pain may differ by sociodemographic factors (like racialized group). Furthermore, access to therapies that promote resilience may be limited across populations. However, the utilization of diet interventions for chronic pain symptoms has also been well-examined. In addition, research has shown that diets can be related to psychological resilience. Therefore, beneficial diets could potentially be utilized as a catalyst to, not only promote resilience, but also reduce pain (in combination with …
Effects Of Single-Cell Dietary Protein Sources On Feeding, Growth, And Resource Allocation In The Juvenile Sea Urchin Lytechinus Variegatus, Darrien Jamila De Jesus
Effects Of Single-Cell Dietary Protein Sources On Feeding, Growth, And Resource Allocation In The Juvenile Sea Urchin Lytechinus Variegatus, Darrien Jamila De Jesus
All ETDs from UAB
An understanding of nutrition can improve culture of sea urchins, whether as a research model or in the production of seafood products. Macronutrients, including dietary protein sources, can affect growth and reproductive profiles and alter resource allocation to somatic and gametic tissues. Although sea urchins in culture can be fed natural products, diet formulations using various ingredients can be developed to reliably produce desired outcomes. Single-cell protein sources represent a potential alternative to current industry standards of animal-derived protein sources such as fish and squid meal, which are becoming increasingly overfished and expensive. In the present study, we evaluated the …
Targeting The Thyroid-Stimulating Hormone Receptor (Tshr) In Thyroid Cancer, Grayson Robert Gimblet
Targeting The Thyroid-Stimulating Hormone Receptor (Tshr) In Thyroid Cancer, Grayson Robert Gimblet
All ETDs from UAB
Radioactive iodine (RAI) has been effective in the treatment of thyroid cancer, the most common endocrine neoplasia, since its introduction into clinical use over eighty years ago. However, not all patients benefit from RAI. Up to 20% of patients with well-differentiated thyroid cancer (WDTC) become radioactive iodine refractory (RAI-R). These RAI-R patients have 5-year survival rates of 50% and 10-year survival rates of 10%. In addition, more aggressive subtypes including oncocytic thyroid carcinoma (OC), poorly differentiated thyroid carcinoma (PDTC), and anaplastic thyroid carcinoma (ATC) are less responsive to RAI therapy. Despite accounting for less than 5% of annual thyroid cancer …
Electrophysiological Integration Of Engineered Tissue Graft With The Host Swine Myocardium, Bijay Guragain
Electrophysiological Integration Of Engineered Tissue Graft With The Host Swine Myocardium, Bijay Guragain
All ETDs from UAB
The adult mammalian heart lacks regenerative capacity to replenish cardiomyocytes (CMs) lost due to myocardial infarction (MI). Instead, the damaged heart undergoes extensive remodeling that significantly impairs normal cardiac function and may eventually lead to heart failure. Recent therapies that implant engineered tissues fabricated from human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have shown promising results with improved cardiac function and structural integration. However, the extent of electrophysiological coupling between engineered and host tissue remains unclear. This is a critical factor for functional integration of the implant as well as for arrhythmia risk arising from the implant. Our study aims …
The Role Of Aquaporin-3 Lysine 282 Acetylation In Renal Water Balance, Nha Van Huynh
The Role Of Aquaporin-3 Lysine 282 Acetylation In Renal Water Balance, Nha Van Huynh
All ETDs from UAB
Aquaporin-3 (AQP3) mediates basolateral water transport in the kidney collecting duct principal cells, contributing to vasopressin-mediated urine concentration. We previously identified a novel post-translational modification of AQP3, the acetylation of lysine 282 (K282), which we hypothesized as a positive regulator of AQP3 water permeability. First, we found that collecting duct K282 acetylated AQP3 increased upon water deprivation, suggesting an involvement in renal water balance. To decipher the functional role of this modification, we utilized AQP3 acetylation (K282Q or Q) and deacetylation (K282R or R) mimetic mutant mice models generated using CRISPR/Cas9 knock-in technology. Both male and female wild-type (WT) and …
Mechanoactivation Of Vegfr-2 Promotes Angiogenesis In The Tumor Microenvironment, Bronte Johnson
Mechanoactivation Of Vegfr-2 Promotes Angiogenesis In The Tumor Microenvironment, Bronte Johnson
All ETDs from UAB
Cancer progression relies on blood vessel growth; without vasculature, tumors would be limited to less than 200µm in diameter. With this reasoning, several cancer therapies have been developed that target the process of angiogenesis, or the growth of vessels off pre-existing vasculature. These treatments target the major promoters of angiogenesis, vascular endothelial growth factor (VEGF) and VEGF receptor 2 (VEGFR-2); however, anti-angiogenic therapies are not effective by themselves. This is likely due to mechanoactivation of VEGFR-2 through physical alterations in the tumor microenvironment (TME). One prevalent mechanical change is increased strain on surrounding cells and matrix due to highly contractile …
Optic Nerve Head Remodeling In Experimental High Myopia, Mahmoud Khalafallah
Optic Nerve Head Remodeling In Experimental High Myopia, Mahmoud Khalafallah
All ETDs from UAB
Myopia is a global health concern, with projected estimates that nearly half of the world's population will be myopic by 2050. While its refractive aspect can be corrected, the heightened susceptibility to sight-threatening comorbidities, particularly with high myopia, remains a challenge. Among these comorbidities, glaucoma is a major concern, with myopia recognized as an independent risk factor. However, the mechanistic link between myopia and glaucoma remains poorly understood. This dissertation investigates the multiscale remodeling changes in experimental high myopia and their potential implications for increased risk of glaucoma later in life. Using a multimodal approach, this dissertation investigates: (1) neural …
Synergistic Effects Of Hyaluronic Acid And Mechanical Strain On Ovarian Cancer Cell Behaviors, Maranda Erin Kramer
Synergistic Effects Of Hyaluronic Acid And Mechanical Strain On Ovarian Cancer Cell Behaviors, Maranda Erin Kramer
All ETDs from UAB
Ovarian cancer is the most lethal gynecological cancer, but despite this, the effects of the ovarian tumor microenvironment (TME) on disease progression are poorly understood. The TME consist of the extra cellular matrix (ECM), cellular components, and mechanical forces. Cancer associated fibroblasts (CAFs) are stromal cells that secrete several ECM components including collagen, fibronectin, and hyaluronic acid (HA). CAFs also have increased motility and contractility, this increased movement creates micro-strains experienced by the tumor cells in the TME. HA interacts with cancer cells as both a serum and stromal component. Increases in stromal HA in the ovarian TME are associated …
Molecular Imaging Of Triple-Negative Breast Cancer: Characterization And Modulation Of The Tumor Microenvironment, Shannon E. Lynch
Molecular Imaging Of Triple-Negative Breast Cancer: Characterization And Modulation Of The Tumor Microenvironment, Shannon E. Lynch
All ETDs from UAB
Triple-negative breast cancer (TNBC) is an aggressive, heterogeneous subset of breast cancer which currently has no targeted therapies available due to lack of molecular therapeutic targets. Importantly, various radiopharmaceuticals can be imaged via positron emission tomography (PET) to quantify cellular and molecular features of the tumor microenvironment including glucose metabolism, receptor status, and immune activation. Somatostatin receptor subtype 2 (SSTR2) is G-protein coupled receptor overexpressed in neuroendocrine tumors (NETs) which can be imaged and targeted for theranostics via FDA-approved radiotherapy. SSTR2 expression is increased in hormone positive breast cancer but is expressed at low or variable levels in TNBC. However, …
A Lament For The Perishing Barbarians Of Edith Wharton’S Summer, Anna Marsh
A Lament For The Perishing Barbarians Of Edith Wharton’S Summer, Anna Marsh
All ETDs from UAB
This thesis considers Edith Wharton’s Summer through a Darwinian perspective. Wharton studied Darwin’s works extensively, so applying The Descent of Man to Summer’s communities has merit. Specifically, I consider Darwin’s writings on evolution as evolution may be altered by feelings of sympathy. In Summer, it is sympathy, loyalty, and ultimate benevolence for one’s people that furthers community evolution as a whole. This relationship between sympathy and community evolution seems to be one Wharton focuses on in Summer. The urban communities of Wharton’s novel pretended to be the most civil and therefore the most evolved, but it is their Mountain neighbors …
Origins Of An Evil God: Conceptualization Of The Demiurge Figure In Plato And Beyond, Brendyn David Matthews
Origins Of An Evil God: Conceptualization Of The Demiurge Figure In Plato And Beyond, Brendyn David Matthews
All ETDs from UAB
This thesis explores the creation of the Demiurge from Plato to the Gnostics. I investigate this early Christian group taking the idea of the Demiurge from Plato and twisting this figure into an evil, malevolent creator. This process involves the Gnostics taking several nodes of development: Plato’s initial conception and Hellenized Egyptians syncretizing Seth with YHWH and mixing them into their worldview to craft their Demiurge. I then answer why these Gnostics made such an entity, understanding that it was them not only trying to supersede Judaism, but the Proto Orthodoxy of Christianity at this time.