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A Life Disrupted: Still Lived, Judith M. Jarosinski Jan 2006

A Life Disrupted: Still Lived, Judith M. Jarosinski

Theses and Dissertations

This research illustrates the experience of living with hallucinations from the perspective of being, and sought to answer the questions: what is the meaning of hallucinations and how do hallucinations connect to one's sense of self?A phenomenological Heideggerian hermeneutic approach was used to guide data collection and analysis. In this study, 12 individuals with schizophrenia or schizoaffective disorders were asked to describe their experience of hallucinations within the context of being. An overarching constitutive pattern emerged with four themes. The constitutive pattern, "A Life disrupted: Still lived," described a pattern of survival and perseverance on one's own terms; a common …

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Determinants Of Care Seeking For Persons With Low Back And Neck Pain Treated By Physicians, Chiropractors Or Physical Therapists, Julia Chevan Jan 2006

Determinants Of Care Seeking For Persons With Low Back And Neck Pain Treated By Physicians, Chiropractors Or Physical Therapists, Julia Chevan

Theses and Dissertations

Low back and neck pain are frequent reasons for adults to seek healthcare. Three types of practitioners are commonly used in the United States: physicians, chiropractors and physical therapists. In this study, Andersen's "Behavioral Model of Health Services Utilization" is used to examine care seeking and provider selection. Estimates of back and neck pain prevalence in the United States are presented as well as care seeking rates and care consumption estimates for patients who used the three providers of interest. Multivariate regression analyses are presented that model the variables that most influence care seeking and provider selection.Cases with the conditions …

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The Association Between Breast Feeding And Being Overweight In Children, Naja Jamil Eldanaf Jan 2006

The Association Between Breast Feeding And Being Overweight In Children, Naja Jamil Eldanaf

Theses and Dissertations

Purpose: Obesity/Overweight in children is an epidemic and the most common disorder of childhood in the developed world. Prevalence is increasing, leading to short- and long-term complications. Breastfeeding may protect against childhood obesity, but the debate is ongoing. The main purpose of this project was to assess the relationship between breastfeeding and being overweight in early childhood.Methods: Data were collected from the State and Local Area Integrated Telephone survey; National Survey of Children's Health, 2003. Overall, 16,358 children, ages 3 to 5, were included in the sample. SPSS Complex Sample software was utilized to generate for all analyses. Complex samples …

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The Effect Of Media Advertising On Consumer Perception Of Orthodontic Treatment Quality, Daenya T. Edwards Jan 2006

The Effect Of Media Advertising On Consumer Perception Of Orthodontic Treatment Quality, Daenya T. Edwards

Theses and Dissertations

A survey instrument was designed to evaluate factors influencing consumer selection of an orthodontist and consumer perception of different forms of media advertising (radio, television, newspaper, magazine, direct mail, and billboard) by orthodontic practices. The surveys were distributed by 8 orthodontic offices in and around the Richmond, Virginia area. Out of 676 surveys, 655 (97%) were returned. Respondents most often cited dentist and patient referrals as how they learned of the orthodontic practices they visited (50%- 57%). However, a caring attitude and good practitioner reputation were cited as the top reasons influencing selection of an orthodontist (53% and 49% respectively). …

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A Twin Study Of Antisocial Behavior And Depression: Methodology, Etiology, And Comorbidity, Kelly A. Tracy Jan 2006

A Twin Study Of Antisocial Behavior And Depression: Methodology, Etiology, And Comorbidity, Kelly A. Tracy

Theses and Dissertations

The etiological connection between internalizing and externalizing disorders is poorly understood. This manuscript aims to investigate the roles of genes and then environment in the development of Major Depressive Disorder (MDD) and Antisocial Personality Disorder (ASPD) and the nature of their comorbidity in young adults. Data from a sample of 2,291 young adult male and female twins from the Young Adult Follow Up Study (YAFU) of the Virginia Twin Study of Adolescent Behavioral Development (VTSABD) were used to estimate the proportion of variation in these traits that can be accounted for by additive genetic, shared environmental, and unique environmental factors. …

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A 'Biorelevant' Approach For Accelerated In Vitro Release And In Vitro-In Vivo Relationship Of A Biodegradable, Naltrexone Implant, Sunil S. Iyer Jan 2006

A 'Biorelevant' Approach For Accelerated In Vitro Release And In Vitro-In Vivo Relationship Of A Biodegradable, Naltrexone Implant, Sunil S. Iyer

Theses and Dissertations

Characterization of in vitro and in vivo drug release profiles constitutes an important step in developing and optimizing an effective, long acting delivery system for naltrexone. Accelerated in vitro methods are also important for quality assurance of manufactured dosage forms. For drug release testing of sustained release parenteral dosage forms, the modified USP Apparatus 4 (flow-through cell) has been recommended by the The Fédération Internationale Pharmaceutique/American Association of Pharmaceutical Scientists (FIP/AAPS) Guidelines. Details on such studies however, are generally not found in the literature. To incorporate 'biorelevance' to implant drug release studies, this research investigated an approach to apparatus design …

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Lifelong Learners Study In Virginia, Dianne Quinn Kurec Jan 2006

Lifelong Learners Study In Virginia, Dianne Quinn Kurec

Theses and Dissertations

The purpose of this study is to identify the current baseline for lifelong learners (age 50 and better) focused on post-secondary education in the Commonwealth of Virginia (VA), the resulting academic services and public policy implications. While the aging research to date is overwhelmingly focused upon health issues, financial security, legislative initiatives, care-giving, and assisted living, etc., fewer studies or data are available on the increasing post-secondary continuing education that lifelong learners will likely expect to be made available to them. The educational level of the growing aging population will continue to increase. Research has repeatedly proven higher education to …

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Electronic Medical Records In Acute Care Hospitals: Correlates, Efficiency, And Quality, Abby Jo Swanson Jan 2006

Electronic Medical Records In Acute Care Hospitals: Correlates, Efficiency, And Quality, Abby Jo Swanson

Theses and Dissertations

The purpose of this dissertation is to examine the organizational and environmental correlates of hospital EMR use and to examine the relationship between hospital EMR use and performance. Using a theoretical framework that combines resource dependence theory with Donabedian's structure, process, outcome model, a conceptual model is created. To test the hypotheses of this model, logistic regression and Data Envelopment Analysis (DEA) are used. The data included in this analysis come from the AHA, HIMSS, CMS, ARF, and HQA. In the analysis of hospitals correlates of EMR use, three hypotheses were supported, and one was partially supported. Hospital system affiliation, …

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Cross-Modal Projections From Auditory To Visual Cortices In The Ferret, Meng Y. Wang Jan 2006

Cross-Modal Projections From Auditory To Visual Cortices In The Ferret, Meng Y. Wang

Theses and Dissertations

Recent studies have shown that neuronal connections occur between primary auditory and visual cortices of the primate (Falchier et al., 2002; Rockland and Ojima, 2003), and it has been suggested that these projections are involved in multisensory processing in these lower-level, core areas of cortex. The present study was conducted to determine if similar connections occur in other higher mammals such as carnivores (ferrets; Mustela putorius). Large injections of sensitive neuroanatomical tracer were placed within the core areas of auditory cortex in 3 ferrets. After transport and processing, labeled axon terminals were found not in primary visual cortex, but in …

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Treatment Effects Of Incisor Positioning On Anterior Tooth Display, Scott J. Eberle Jan 2006

Treatment Effects Of Incisor Positioning On Anterior Tooth Display, Scott J. Eberle

Theses and Dissertations

The purpose of this study was to determine the effect of changes in maxillary incisor position on anterior tooth display (ATD) in adult (n = 21) and adolescent (n = 38) orthodontic patients. The effects of anterior-posterior, vertical, and angular changes of the maxillary central incisor position during orthodontic treatment were evaluated relative to changes in the amount of ATD measured from pretreatment (TI) and posttreatment (T2) lateral cephalometric radiographs of existing patient records.Results showed a significant relationship between starting ATD and ATD change during treatment for both adults (P = ,006) and adolescents (P

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Factorial Validity Of The Team Skills Scale As Used For Geriatric Interdisciplinary Team Training (Gitt), Myra G. Owens Jan 2006

Factorial Validity Of The Team Skills Scale As Used For Geriatric Interdisciplinary Team Training (Gitt), Myra G. Owens

Theses and Dissertations

Objective: To examine the factorial validity of the Team Skills Scale (TSS). The TSS is a 17-item scale developed by Hepburn, Tsukuda, and Fasser (1996). The Scale is purported to assess self-perceived team skills.Data Source: Data for this study were provided by The New York University Geriatric Interdisciplinary Team Training (GITT) Resource Center and were collected as part of the evaluation of the GITT program. The data were collected between January 1997 and June 2000.Study Design: This quasi-experiential study was focused on the trainee (N=1,715) as the unit of analysis. The Model of Individual-Level Team Competencies (Model of I-LTC) served …

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Welcome To The Branch, Turia R. Pope Jan 2006

Welcome To The Branch, Turia R. Pope

Theses and Dissertations

Welcome to the Branch is a two-act play that investigates issues of cultural differences in the Church of Jesus Christ of Latter Day Saints (or LDS church), more commonly known as the Mormon Church. Set in modern-day, downtown Richmond, Welcome to the Branch follows two very different members of the LDS church as they examine and try to understand both their religion, in the context of its cultural and social history, and their place in it. One is Molly, a Caucasian, middle-class young woman from Utah, in Richmond temporarily for her husband's graduate school; the other is Aina, an African …

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Immunotoxicological Evaluation Of Critical Windows Of Development Following Exposure To 1,2:5,6 Dibenzanthracene In B6c3f1 Mice, Denise Marie Hernandez Jan 2006

Immunotoxicological Evaluation Of Critical Windows Of Development Following Exposure To 1,2:5,6 Dibenzanthracene In B6c3f1 Mice, Denise Marie Hernandez

Theses and Dissertations

Numerous findings have suggested that the increased prevalence of childhood illnesses such as cancer, infection, and allergy may be due to environmental exposures. One such cause may be maternal smoking or passive smoke exposure. Known immunotoxicants in cigarette smoke and environmental pollution include polycyclic aromatic hydrocarbons such as 1,2:5,6 Dibenzanthracene (DBA). The objective of these studies was to evaluate the immunosuppressive effects of DBA on various stages of immune system development. Adult mice were administered DBA daily in corn oil at dose levels of 158, 500, 1580, and 5000 µglkg S.C. for 28 days. Immunosuppression was not observed at levels …

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Regulation Of Murine Mast Cell Homeostasis By Tgf-Β1 And Cd4+Cd25+C Regulatory T Cells, Mohit Kashyap Jan 2006

Regulation Of Murine Mast Cell Homeostasis By Tgf-Β1 And Cd4+Cd25+C Regulatory T Cells, Mohit Kashyap

Theses and Dissertations

Understanding mast cell development is central to allergic disease pathophysiology. Our laboratory has previously shown that cytokines such as IL-4 and IL-10 inhibit mast cell development from bone marrow progenitors. These studies encouraged our interest in other regulatory cytokines, including transforming growth factor β1 (TGF- β1). TGF- β1 has many cellular sources, one of which is CD4+CD25 regulatory T cells (Tregs). We wanted to determine the effects of Transforming Growth Factor (TGF) βl on mast cell development. We find that TGFβl decreased FcεRI, c-Kit, T1/ST2 and FcεR expression, and inhibited granule formation in developing mast cells. Accessory cells were not …

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Influence Of The Vitamin D3 Analog Eb 1089 On Senescence And Cell Death Pathways In The Response Of Breast Tumor Cells To Ionizing Radiation, Gerald Alan Demasters Jan 2006

Influence Of The Vitamin D3 Analog Eb 1089 On Senescence And Cell Death Pathways In The Response Of Breast Tumor Cells To Ionizing Radiation, Gerald Alan Demasters

Theses and Dissertations

A senescence-like growth arrest succeeded by rapid recovery of proliferative capacity is observed in MCF-7 breast tumor cells exposed to fractionated radiation (5 x 2Gy) alone. Exposure to the vitamin D3 analog EB 1089 (100nM) prior to irradiation converts the initial growth arrest response to cell death in part through the inhibition of radiation-induced senescence and promotion of both apoptotic and autophagic cell death. More importantly, EB 1089 was shown to profoundly reduce the rate of recovery following fractionated irradiation. The effect of EB 1089 on the temporal response to radiation is also observed in MCF-7 cells expressing caspase 3, …

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An Examination Of Career Decision-Making In The Context Of Female Offenders, Allison L. Stone Jan 2006

An Examination Of Career Decision-Making In The Context Of Female Offenders, Allison L. Stone

Theses and Dissertations

Female offenders often have had increased financial difficulties post-release because of lower levels of educational achievement and less job experience. Career programming may prove useful to female offenders by providing guidance with career decisions and strengthening career decision-making skills. The aims of this study were to investigate career decision-making skills and self-efficacy in the context of vocational programming for a group of female offenders. A pretest-posttest quasi-experimental design was used to examine scale scores for a group who participated in programming and a control group at the same correctional facility. A series oft tests revealed no significant differences between the …

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Poverty, Inequality & Terrorism Relationship In Turkey, Mutlu Koseli Jan 2006

Poverty, Inequality & Terrorism Relationship In Turkey, Mutlu Koseli

Theses and Dissertations

Poverty, Inequality & Terrorism Relationship in TurkeyUsing empirical evidence criminological studies have identified a relationship between poverty and crime and many studies have concluded that a high crime rate is associated with a higher poverty rate. Other studies indicate that inequalities are a better determinant of crime than absolute poverty. Social disorganization theory, anomie strain theory and Marxist theory have been used to explain the phenomenon. Guided by the aforementioned theories and previous literature on crime, this study looks at the terrorism issue and explores whether a relationship exists between poverty, inequality and terrorist incidents. The main hypothesis of this …

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Rich, Attractive People In Attractive Places Doing Attractive Things, Tonya Walker Jan 2006

Rich, Attractive People In Attractive Places Doing Attractive Things, Tonya Walker

Theses and Dissertations

Rich, Attractive People in Attractive Places Doing Attractive Things is a fictional memoir of a dead Manhattan socialite from the 1950's named Sunny Marcus. The novel is Sunny's monologue from Hell and features many well-known figures from American pop culture including Truman Capote, Ernest Hemingway, Clark Gable, William Powell and Babe Paley. It traces the upward trajectory of Sunny's life from a modest childhood in 1920's Los Angeles to the heights of social success in the unforgiving world of Café Society to her murder.

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Combinatorial Modulation Of Multiple Signaling Pathways To Gain Therapeutic Response In Breast And Prostate Cell Carcinomas, William Tressel Hawkins Ii Jan 2006

Combinatorial Modulation Of Multiple Signaling Pathways To Gain Therapeutic Response In Breast And Prostate Cell Carcinomas, William Tressel Hawkins Ii

Theses and Dissertations

Our laboratory is primarily interested in novel pharmacological intervention of cell proliferation and survival pathways expressed in various types of cancer. These cyto-protective pathways can be activated in response to growth factor stimulation, toxic insult and radiation. In our studies, we utilized novel drug combinations with and without radiation to enhance breast & prostate tumor cell death both in vitro and in vivo. Previous studies from our group have shown that UCN-01 and MEK1/2 inhibitors interact to cause tumor cell death in transformed cell lines in vitro. We extended this observation to an in vivo animal model system using the …

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Length Of Hospital Stay, Delirium And Discharge Status Outcomes Associated With Anticholinergic Drug Use In Elderly Hospitalized Dementia Patients, Kelly J. Gauthier Jan 2006

Length Of Hospital Stay, Delirium And Discharge Status Outcomes Associated With Anticholinergic Drug Use In Elderly Hospitalized Dementia Patients, Kelly J. Gauthier

Theses and Dissertations

Problem: There are a significant proportion of patients taking acetylcholinesterase inhibitors (ChEi) for cognitive dysfunction also taking medications with anticholinergic (ACh) properties that may counteract their effects. As the number of ACh medications, burden, increases so does the likelihood of an adverse outcome.Background: ACh medications are frequently used in the elderly population (Carnahan 2004) even those with dementia or AD (Roe et al., 2002; Giron et al., 2001; Altavela 2003; Gill et al., 2005; Kogut et al., 2005). Methods: Hospitalized patients > 65 years of age with dementia (AD, other dementias, or with inferred dementia based on ChEi or NMDA antagonist …

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Effect Of Nitric Oxide On Oxygen Consumption Of Skeletal Muscle, Christina Lyn Cox Jan 2006

Effect Of Nitric Oxide On Oxygen Consumption Of Skeletal Muscle, Christina Lyn Cox

Theses and Dissertations

Mammalian cells require a continuous and sufficient supply of oxygen to carry out their functions. The oxygen pathway has an overall direction taking O2 from the air to the mitochondria, which is a result of the mitochondrial O2 consumption (VO2) NO various effects on the mitochondria: at low concentrations for short periods NO specifically and irreversibly inhibits cytochrome c and reversibly inhibits cytochrome c oxidase, to decrease VO2. Thus, NO can modulate VO2 of skeletal muscle. The purpose of the present study was to measure VO2 of the rat spinotrapezius muscle under conditions of altered NO. The methods used provide …

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Intimate Encounters; Staging Intimacy And Sensuality, Tonia Sina Campanella Jan 2006

Intimate Encounters; Staging Intimacy And Sensuality, Tonia Sina Campanella

Theses and Dissertations

This text is a partial record of the conception and development of Reflections of Red in a Mirror of Desire that opened on February 20th 2006 for a three day run ending on February 22nd. The majority of the text is focused on the events and research that provided the concept for the show. Some of the research includes influential choreographers and companies such as Pina Bausch, Graziela Daniele, Moses Pendleton, Pilobolus, Momix, Julie Tayrnor, and Merce Cunningham. Included in the analysis of this event are the experiences and lessons that came about during the process of directing Reflections of …

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The Determinants Of Hospital Adoption And Expansion Of Bariatric Procedures: A Resource Dependence Perspective, Wenquiang Tian Jan 2006

The Determinants Of Hospital Adoption And Expansion Of Bariatric Procedures: A Resource Dependence Perspective, Wenquiang Tian

Theses and Dissertations

New medical technologies have been viewed as the primary cause of rising health are expenditures by health policy researchers in the United States. Since the mid 1990s, with the prevalence of obesity among Americans, the utilization of bariatric surgery, a medical innovation, has increased rapidly among U.S. hospitals. Generally, current literature only states that the volume of bariatric procedures is increasing dramatically.Very limited studies have been conducted to investigate the growth of bariatric procedures.The objective of this study is (1) to provide a detailed description about the adoption and utilization of bariatric procedure in hospitals in 11 states, and (2) …

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Information Technology Outsourcing In U.S. Hospital Systems, Mark L. Diana Jan 2006

Information Technology Outsourcing In U.S. Hospital Systems, Mark L. Diana

Theses and Dissertations

The purpose of this study was to determine the factors associated with outsourcing of information systems (IS), and if there is a difference in IS sourcing based on the strategic value of the outsourced functions. The theoretical framework is based upon a synthesis of strategic management theory (SMT) and transaction cost economics (TCE) as they apply to vertical integration in the health care sector; therefore, IS sourcing behavior was conceptualized as a case of vertical integration. The conceptual model proposed that sourcing behavior would be determined by asset specificity, uncertainty, the interaction of asset specificity and uncertainty, bargaining power, corporate …

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A Comparison For Longitudinal Data Missing Due To Truncation, Rong Liu Jan 2006

A Comparison For Longitudinal Data Missing Due To Truncation, Rong Liu

Theses and Dissertations

Many longitudinal clinical studies suffer from patient dropout. Often the dropout is nonignorable and the missing mechanism needs to be incorporated in the analysis. The methods handling missing data make various assumptions about the missing mechanism, and their utility in practice depends on whether these assumptions apply in a specific application. Ramakrishnan and Wang (2005) proposed a method (MDT) to handle nonignorable missing data, where missing is due to the observations exceeding an unobserved threshold. Assuming that the observations arise from a truncated normal distribution, they suggested an EM algorithm to simplify the estimation.In this dissertation the EM algorithm is …

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Public: An Exploration Of Community, Environment, And Technology, Christopher John Malven Jan 2006

Public: An Exploration Of Community, Environment, And Technology, Christopher John Malven

Theses and Dissertations

This project examines the potential of computer technology to enhance navigation within, and incorporate information-sharing into, the public urban environment.

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The Influence Of A Single Nucleotide Polymorphism In The Matrix Metalloproteinase-1 Promoter On Glioma Biology, Jessica Mccready Jan 2006

The Influence Of A Single Nucleotide Polymorphism In The Matrix Metalloproteinase-1 Promoter On Glioma Biology, Jessica Mccready

Theses and Dissertations

Glioblastomas are an incurable type of brain tumor with a mean survival time of 9-12 months following diagnosis. One of the reasons for this poor prognosis is the ability of tumor cells to invade the surrounding normal brain tissue. Enzymes responsible for this invasive nature include the matrix metalloproteinase family. MMP-1 is a member of this family which has been well studied in many types of invasive tumors, with gliomas being an exception. We studied a single nucleotide polymorphism (SNP) in the MMP-1 promoter that may influence glioma biology. This SNP consists of the presence (2G) or absence (1G) of …

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Perceived Deprivation In Active Duty Military Nurse Anesthetists, Julie Ann Pearson Jan 2006

Perceived Deprivation In Active Duty Military Nurse Anesthetists, Julie Ann Pearson

Theses and Dissertations

Problem: There is a shortage of military certified registered nurse anesthetists (CRNAs). The exodus from military service to civilian careers could be a result of relative deprivation (the discrepancy that one perceives between what one has and what one could or should have). Relative deprivation is a perception of unfairness dependent on feelings (subjective data) as well as facts (objective data). Purpose: The purpose of this study was to measure relative deprivation in active duty military nurse anesthetists, to explore variables which correlate with relative deprivation, and to validate or refute the theory of relative deprivation in active duty military …

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Action Of Tyrosyl Dna Phosphodiesterase On 3'-Phosphoglycolate Terminated Dna Strand Breaks, Haritha Tatavarthi Jan 2006

Action Of Tyrosyl Dna Phosphodiesterase On 3'-Phosphoglycolate Terminated Dna Strand Breaks, Haritha Tatavarthi

Theses and Dissertations

Free radical-mediated DNA double strand breaks (DSBs) are induced either directly by ionizing radiation or by certain chemicals like bleomycin. These breaks are terminated by 3'-PG (PO4CH2COOˉ) or 3'-phosphate groups formed as a result of fragmentation of deoxyribose. To study the nature of repair of these 3'-blocked breaks, we constructed substrates mimicking free-radical induced DSBs. Human and yeast tyrosyl DNA-phosphodiesterase (Tdpl) efficiently processed substrates with 3'-PGs, in either the presence or absence of magnesium, to give a 3'-phosphate. Gel filtration chromatography and western blotting codmed that the putative enzyme in human extracts that efficiently processed PG was indeed tyrosyl DNA-phosphodiesterase. …

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A Determination Of The Association Of Competition And Regulation With Hospital Strategic Orientation, Kathleen B. Heatwole Jan 2006

A Determination Of The Association Of Competition And Regulation With Hospital Strategic Orientation, Kathleen B. Heatwole

Theses and Dissertations

This research study examines the influence of two major forces, competition and regulation, on the strategic orientation of hospitals. This is a particularly relevant subject, as the effectiveness of competition versus the effectiveness of regulation in the health care market has been called one of the Bellwether issues in health care policy, and the most controversial and far reaching philosophical battle facing the health care industry. Even after three decades of research and debate, there is still no consensus on how the hospital industry responds to either a competitive environment or a regulated environment. There continues to be significant variation …

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