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The Anti-Plaque Efficacy Of Listerine® Used In Combination With Toothbrushing In Orthodontic Patients, Zachary A. Casagrande Jan 2006

The Anti-Plaque Efficacy Of Listerine® Used In Combination With Toothbrushing In Orthodontic Patients, Zachary A. Casagrande

Theses and Dissertations

The bactericidal efficacy of Listerine®, the essential oil-containing mouthrinse, has long been recognized. The purpose of this study was to determine whether Listerine® mouthrinse, when added to the standard oral hygiene regimen, had an added benefit in reducing plaque and gingivitis development in orthodontic patients over a six-month period. 50 orthodontic patients from the Virginia Commonwealth University Department of Orthodontics were assigned either to the brushing + flossing (N= 25) or brushing + flossing + Listerine® (N = 25) group. At baseline (TI), measurements for the Ramfjord teeth were recorded for the gingival index, plaque index and bleeding index. Subsequent …

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Is Safe Haven Legislation An Efficacious Policy Response To Infant Abandonment: A Biopsychosocial Profile Of The Target Population, Stephanie Mayes Gruss Jan 2006

Is Safe Haven Legislation An Efficacious Policy Response To Infant Abandonment: A Biopsychosocial Profile Of The Target Population, Stephanie Mayes Gruss

Theses and Dissertations

This study represents an attempt to describe the extent and features of safe haven legislation in the United States, discuss implementation issues, and to examine if the legislation is reaching its intended target audience in order to answer the question, "Is safe haven legislation an efficacious response to infant abandonment?" Safe havens are designated locations where infants can be anonymously abandoned without fear of prosecution or incarceration. As of May of 2006, forty-seven states have passed such legislation, citing the need for an alternative to unsafe infant abandonment leading to an infant's death, and an alternative to infanticide (the killing …

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The Post-9/11 Federal Homeland Security Paradigm And The Adoptive Capacity Of Public Administration Theory And Practice, Chaya Rani Jain Jan 2006

The Post-9/11 Federal Homeland Security Paradigm And The Adoptive Capacity Of Public Administration Theory And Practice, Chaya Rani Jain

Theses and Dissertations

The September 11, 2001 terrorist attacks redefined the federal approach to disaster planning. Prior to 9/11, disaster and emergency management meant preparedness for and response to natural and man-made emergencies such as floods, hurricanes, fires, and civil discord. The post-9/11 paradigm shift, a multi-pronged approach called "homeland security" strategy, now incorporates a multitude of man- and nature-made disasters to include border and transportation security; emergency preparedness, response and recovery against chemical, biological, radiological and nuclear threats; as well as information analysis and infrastructure protection. These new priorities were communicated to the state and local governments. The purpose of this descriptive, …

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Inhibition Of Margination And Diapedesis Of Neutrophils By Protein Synthesis Blockade, Phyllis V. Acquah Jan 2006

Inhibition Of Margination And Diapedesis Of Neutrophils By Protein Synthesis Blockade, Phyllis V. Acquah

Theses and Dissertations

Acute Respiratory Distress Syndrome (ARDS), an age-old clinical problem facing the Emergency Department and Intensive Care Units of all health systems, is a common debilitating lung condition consequent upon severe systemic inflammation. Although several studies have gone into understanding the epidemiology and pathogenesis of the disease thus making way for new advances in treatment strategies, there seems to be no known study tailored to its prevention. Neutrophil extravasation within the tissues during inflammation is the hallmark of this syndrome. Our study sought to block excessive neutrophil infiltration by inhibiting the biosynthesis of some essential proteins necessary for the process. In …

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Southeast Asian Immigrant Women's Perspectives On Domestic Violence, Pataporn Saengkhiew Jan 2006

Southeast Asian Immigrant Women's Perspectives On Domestic Violence, Pataporn Saengkhiew

Theses and Dissertations

This study addresses the question, "What is the lived experience of Southeast Asian immigrant women who live in the United States related to domestic violence, including the relationships with their partners, their knowledge of domestic violence, and the existence of domestic violence in the Asian community?" Fourteen Thai women engaged in semistructured interviews during which they were asked to describe their experience. This study chose the phenomenological approach, using content analysis that identified six major themes representing essential aspects of the experience, as described by the participants: (a) Knowledge about Domestic Violence and Sources of Information, (b) The experience of …

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Use Of A Synthetic Substrate For Orthodontic Bond Strength Testing, Elijah B. Saikaly Jan 2006

Use Of A Synthetic Substrate For Orthodontic Bond Strength Testing, Elijah B. Saikaly

Theses and Dissertations

In vitro bond strength studies are of great importance and interest since they allow the prediction of clinical success of orthodontic adhesives. There are many studies that have investigated bond strength values of bonding systems. However, due to the variation in the materials and methods employed, it is very difficult and often impossible to make comparisons among data. The use of a substrate as an alternate to enamel for mechanical tests would minimize these variables and reduce the challenges faced with in vitro bond strength tests. The purpose of this study was to investigate the suitability of Macor as a …

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Characterization Of Perphenazine And Scopolamine Aerosols Generated Using The Capillary Aerosol Generator, Xihao Li Jan 2006

Characterization Of Perphenazine And Scopolamine Aerosols Generated Using The Capillary Aerosol Generator, Xihao Li

Theses and Dissertations

The characterization of perphenazine and scopolamine aerosols generated using the capillary aerosol generator (CAG) was reported. Variables including steady state power, the formulation vehicle, the drug concentration and the formulation flow rate were studied for their effects on the chemical stability and particle size of these drug aerosols.Stability-indicating HPLC and LC-MS assays were developed and validated for perphenazine and scopolamine, respectively. The chemical stability of each compound was investigated under a variety of stress conditions and the structure of degradation products was proposed.Perphenazine aerosols were generated from propylene glycol (PG) formulations with concentrations of 9, 48 and 90mM at formulation …

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Diffuse Brain Injury Triggers Ultra-Rapid Perisomatic Traumatic Axonal Injury, Wallerian Change, And Non-Specific Inflammatory Responses, Brian Joseph Kelley Jan 2006

Diffuse Brain Injury Triggers Ultra-Rapid Perisomatic Traumatic Axonal Injury, Wallerian Change, And Non-Specific Inflammatory Responses, Brian Joseph Kelley

Theses and Dissertations

A significant component of diffuse brain injury (DBI) is diffuse axonal injury (DAI) which is responsible for the morbidity and mortality associated with this condition. DAI and its experimental counterpart traumatic axonal injury (TAI) result in scattered microscopic pathology characterized by focal impairment of axonal transport leading to progressive swelling and delayed axotomy. DBI-mediated perisomatic axotomy does not result in acute neuronal death suggesting that delayed axotomy was responsible for this unanticipated response. To evaluate this hypothesis, we examined the spatiotemporal progression of DBI-mediated perisomatic TAI. LM / TEM identified impaired axonal transport within 15 - 30 min post-injury. Perisomatic …

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Ige Production Regulation Via Cd23 Stalk Engagement And Cell Cycle Stimulation, Timothy Hays Caven Jan 2006

Ige Production Regulation Via Cd23 Stalk Engagement And Cell Cycle Stimulation, Timothy Hays Caven

Theses and Dissertations

CD23, the low affinity receptor for IgE, is expressed mainly on B cells and has been shown to regulate IgE production. Previously, recombinant mouse and human CD23 were constructed with a trimerizing isoleucine zipper motif attached in frame to the N-terminus of the entire extracellular CD23 (lz-ECCD23). The goal was to examine the role of the necessity of the CD23 stalk for binding IgE. Using PCR-based mutagenesis to delete the majority of the stalk, binding to IgE was lost. Further studies examined the effect of lz-ECCD23 in preventing IgE from binding FcεRI and therefore acting as a therapeutic agent. It …

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The Expression And Function Of Wilms' Tumor 1 In Malignant Glioma, Aaron J. Clark Jan 2006

The Expression And Function Of Wilms' Tumor 1 In Malignant Glioma, Aaron J. Clark

Theses and Dissertations

The Wilms' tumor 1 gene is overexpressed in many types of cancer and is associated with poor prognosis and resistance to anti-cancer therapies. In vitro studies in non-glioma cells types have demonstrated that WTl plays a role in increased proliferation, resistance to apoptosis, and increased cellular invasion. We aimed to thoroughly characterize the expression pattern of Wilms' tumor 1 in human malignant glioma and discern its function in this complex disease process. We screened a large sample of established human malignant glioma cell lines and glioma tissue specimens of all grades for WT1 expression. The majority of cell lines and …

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Comparison Of Leukocyte Classes Most Likely To Cause Vascular Dysfunction In Preeclampsia, Kristen Anne Cadden Jan 2006

Comparison Of Leukocyte Classes Most Likely To Cause Vascular Dysfunction In Preeclampsia, Kristen Anne Cadden

Theses and Dissertations

Leukocytes are activated in women with preeclampsia, but the class of leukocyte most likely to cause vascular dysfunction is not known. We hypothesized that neutrophils may be the class of leukocyte most involved in causing this dysfunction because neutrophils are the most abundant of the leukocytes and their numbers increase during pregnancy. In this study we compared vascular infiltration of neutrophils (CD66b) with monocytes/macrophages (CD14) and lymphocytes (CD99) in normal non-pregnant women (NNP), normal pregnant women (NP), and preeclamptic women (PE). There was no significant difference in the infiltration of lymphocytes into the maternal vasculature in PE as compared to …

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A Model For Studying Vasogenic Brain Edema, Anshu Shukla Jan 2006

A Model For Studying Vasogenic Brain Edema, Anshu Shukla

Theses and Dissertations

Convection-enhanced delivery (CED) is a proven method for targeted drug delivery to the brain that circumvents the blood-brain barrier (BBB). Little study has been conducted in understanding CED in pathological brain states. This is of importance when dealing with chemotherapeutic agent delivery to brain tumors, where vasogenic edema (VE) exists. The current study aims to characterize a model of VE suitable for studying CED.VE was produced in the right hemisphere of the rat brain using multiple infusions of hyperosmotic mannitol (0.25mL/kg/s over 30 seconds) delivered through the right internal carotid artery. Magnetic resonance imaging (MRI) revealed consistent edema formation and …

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The Motives And Experiences Of College Students Who Choose To Abstain From Drinking Alcohol, Lisa Proakis-Stone Jan 2006

The Motives And Experiences Of College Students Who Choose To Abstain From Drinking Alcohol, Lisa Proakis-Stone

Theses and Dissertations

Objective: Numerous studies trying to find the causes and implications of binge drinking on college campuses have focused their attention on the heavy drinkers. The purpose of this study was to understand why and how college students choose to abstain from drinking. The study also examined the experiences of the abstaining college students on a campus where 83% of the student body drinks. Methods: Twelve undergraduate students from the University of Richmond participated in this qualitative study. Individual interviews using open-ended questions were conducted to ascertain the reasons for their abstinence and their experiences as college students. After the interviews, …

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Applying Principles Of Information Design To Help Parents Accept Babies With Down Syndrome, Anita Eradla Jan 2006

Applying Principles Of Information Design To Help Parents Accept Babies With Down Syndrome, Anita Eradla

Theses and Dissertations

My creative project is a system of resource materials designed for parents and expecting parents to promote acceptance of babies with Down syndrome. This project is also a study of information architecture and icon development, and an opportunity to study the universal and emotive qualities of an iconic system.

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Determinants Of Dating Violence Among Youth In The U.S., Candace Hamm Jan 2006

Determinants Of Dating Violence Among Youth In The U.S., Candace Hamm

Theses and Dissertations

Background: Physical Dating Violence (PDV) victimization is a major public health concern among adolescents in the United States. Research has shown that determinants of PDV victimization are different for male and female adolescents. However, inconsistent findings entail that further research needs to be done using a representative sample of male and female adolescents.Objective: To identify gender-specific determinants of PDV victimization utilizing a nationally representative sample of high school adolescents.Methods: Data from the 2005 National Youth Risk Behavior Survey was used for this analysis. The study population included 6.951 male and 6,807 female students in grades 9 through 12. Bivariate and …

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Healing Interior: Using Eastern Design Principles In Hotel Design, Yunju Lee Koh Jan 2006

Healing Interior: Using Eastern Design Principles In Hotel Design, Yunju Lee Koh

Theses and Dissertations

The main goal of this thesis is to explore how interior spaces in hotel designs can provide a less stressful environment and promote health and harmony by using Feng Shui Principles. It will first discuss the principles of Feng Shui and general hotel design, and then move on to demonstrate how the application of Feng Shui principles can be used to create a hotel environment that encourages health and harmony in its occupants. This project will demonstrate principles that not only can be applied to hotel space, but also can be practiced in any other interior space. This thesis, therefore, …

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Vcu/Monroe Park Fall Festival: Celebrating The Heart Of Vcu, The Grace E. Harris Leadership Institute At Virginia Commonwealth University, Gail Bartee, Bryan Brown, Clare Green, Edward Howard, Christine Isaacs, Ronald Miller, Mike O'Berry, Patty Strong Jan 2006

Vcu/Monroe Park Fall Festival: Celebrating The Heart Of Vcu, The Grace E. Harris Leadership Institute At Virginia Commonwealth University, Gail Bartee, Bryan Brown, Clare Green, Edward Howard, Christine Isaacs, Ronald Miller, Mike O'Berry, Patty Strong

The Grace E. Harris Leadership Institute Publications

The “VCU/Monroe Park Fall Festival” seeks to create a unifying comprehensive fall festival tradition for both VCU campuses. Our proposal responds to the VCU2020 strategic plan by creating a festival designed to highlight VCU/community partnerships and promote “One VCU”. Theme V of the strategic plan emphasizes “maintain[ing] VCU as a model for university-community partnerships” and “develop[ing] collaborations between businesses, government agencies, [and] communities …”. Individual units across the university will respond to these initiatives in countless ways, but unless we promote our community partnerships in a unified, centrally located, vibrant and celebratory way, much of what we do will remain …

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The Effect Of Variability In Substance Abuse And Dependence Terminology On Physicians' Prescribing Decisions, Lisa Rochelle Burroughs Phipps Jan 2006

The Effect Of Variability In Substance Abuse And Dependence Terminology On Physicians' Prescribing Decisions, Lisa Rochelle Burroughs Phipps

Theses and Dissertations

Prescription drug abuse is a continuing problem in the United States. Educating physicians on issues related to prescription drug abuse is a key factor in preventing and treating this problem. High variability has been found in substance abuse terminology in the literature, textbooks, and FDA-approved product labeling. This dissertation describes a survey study designed to address how the variability in substance abuse terminology, specifically package inserts, affects the prescribing decisions made by physicians.A random sample of 1008 physicians currently licensed and residing in the Commonwealth of Virginia received a letter of explanation, a self-administered questionnaire, and a follow-up reminder and …

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Virginia Dental Journal (Vol. 83, No. 2, 2006) Jan 2006

Virginia Dental Journal (Vol. 83, No. 2, 2006)

Virginia Dental Journal

No abstract provided.

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Identification Of Novel Allosteric Regulators Of Human Erythrocyte Pyruvate Kinase, Shilpa S. Kharalkar Jan 2006

Identification Of Novel Allosteric Regulators Of Human Erythrocyte Pyruvate Kinase, Shilpa S. Kharalkar

Theses and Dissertations

Erythrocyte pyruvate kinase (R-PK) is a key glycolytic enzyme catalyzing the transphosphorylation of phosphoenolpyruvate (PEP) and ADP to pyruvate and ATP respectively3,4. The substrate PEP and product pyruvate of this reaction are involved in a number of energetic and biosynthetic pathways; hence a tight regulation of R-PK activity is crucial not only for glycolysis, but also for the entire cellular metabolism. Deficiency of R-PK is one of the most common enzymatic defects of RBC, and may be caused by mutations of the PK-LR (pyruvate kinase liver red blood cell) gene31, 32. Clinically, R-PK deficiency manifests itself as a chronic life-long …

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Rebuilding Theories Of Technology Acceptance: A Qualitative Case Study Of Physicians' Acceptance Of Technology, Jon T. Blue Jan 2006

Rebuilding Theories Of Technology Acceptance: A Qualitative Case Study Of Physicians' Acceptance Of Technology, Jon T. Blue

Theses and Dissertations

The Technology Acceptance Model has been widely applied and has been quite successful at explaining the behavioral intention to use technology in many organizations. One of the most significant variables in the Technology Acceptance Model is perceived ease of use. The Technology Acceptance Model purports that perceived ease of use contributes to the behavioral intention to use technology. Additionally, the model purports that perceived ease of use is an antecedent of perceived usefulness. In the adoption and use of technology by physicians, previous studies show that the Technology Acceptance Model predictions have been incorrect. Specifically, the aforementioned perceived ease of …

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Functional Consequences Of Matrix Metalloproteinase-1 Over-Expression In Human Gliomas, Emily Mullet Jan 2006

Functional Consequences Of Matrix Metalloproteinase-1 Over-Expression In Human Gliomas, Emily Mullet

Theses and Dissertations

Malignant brain tumors are among the deadliest of human cancers. Despit recent advancements in conventional therapies, glioblastomas remain incurable, largel y due to their ability to invade surrounding tissue. Matrix metalloproteinases are thought to contribute to the invaseive phenotype of human gliomas. Absent in normal brain, matrix metalloproteinase-1 (MMP-1) has been shown to be present in gliomas, and in particular in glioblastoma multiforme (GBM). To begin to examine the role of MMP-1 in these tumore, two human glioma cell lines were stably transfected with MMP-1 cDNA. Confirmation of MMP-1 over-expression in these cells was achieved through real-time PCR and Western …

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The Effect Of Adding Drag-Reducing Polymers To Resuscitation Fluid During Hemorrhagic Shock On Skeletal Muscle Microcirculation, Geoffrey C. Alexander Jan 2006

The Effect Of Adding Drag-Reducing Polymers To Resuscitation Fluid During Hemorrhagic Shock On Skeletal Muscle Microcirculation, Geoffrey C. Alexander

Theses and Dissertations

Previous studies have shown an increase in survival when a minute amount of drag-reducing polymers were added to a resuscitation fluid. The purpose of this investigation was to examine the effect of adding a minute amount of the drag-reducing polymer polyethylene glycol to a resuscitation fluid, on the microcirculation of skeletal muscle during a volume-controlled hemorrhage model. The spinotrapezius muscle in twelve male Sprague Dawley rats was exteriorized for microvascular measurements of the arterioles. The diameters of the three levels of arterioles, interstitial fluid PO2, and RBC velocity in the feed arteriole were measured. Flow in the feed arteriole was …

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The Ins And Outs Of School Provider Literature: A Multi-Year Content Analysis On Lgbt Youth, Caitlin Conor Ryan Jan 2006

The Ins And Outs Of School Provider Literature: A Multi-Year Content Analysis On Lgbt Youth, Caitlin Conor Ryan

Theses and Dissertations

This study is based on a content analysis of two primary sources: 1) literature published on lesbian, gay, bisexual and transgender (LGBT) youth in professional journals for school providers (school counselors, nurses, psychologists and social workers) over more than a 30-year period; and 2) materials developed for school providers on LGBT youth by states with laws, regulations and professional policies related to sexual orientation and/or gender identity in schools. Fifteen professional journals were identified that serve as primary and secondary journals for school providers. A total of 41 articles were published in these journals on LGBT youth between 1937 and …

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Sinking Poor Decision-Making With Best Practices: A Case Study Of Artificial Reef Decision-Making In The Florida Keys, Thomas Wayne Williams Jan 2006

Sinking Poor Decision-Making With Best Practices: A Case Study Of Artificial Reef Decision-Making In The Florida Keys, Thomas Wayne Williams

Theses and Dissertations

The natural reefs of the world are experiencing higher use and pressures, resulting in anthropogenic impacts that are deteriorating many coral stands and creating poor water quality. The Florida Keys rely primarily on the reef system that surrounds the archipelago for their socioeconomic health and successful future. The Florida Keys shares the symbiotic relationship of the terrestrial and marine realms with many other states and countries and the experience of higher demand on the resource. Artificial reefs could provide a substitute to the natural reefs for commercial and recreational users. An increased demand for derelict vessels of the U.S. Navy …

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Characterization And Functional Analysis Of A Newly Identified Human Mt5-Mmp Transcript Variant Isolated From Multipotent Nt2 Cells, Heather Hamilton Ross Jan 2006

Characterization And Functional Analysis Of A Newly Identified Human Mt5-Mmp Transcript Variant Isolated From Multipotent Nt2 Cells, Heather Hamilton Ross

Theses and Dissertations

Membrane-type 5 matrix metalloproteinase (MT5-MMP) is unique among MMP family members as it is predominately expressed in the CNS. Its expression is ubiquitous during brain development and restricted to regions of neurogenesis and neuroplasticity in the adult. MT5-MMP is a mediator of pericellular proteolysis and is thought to have a functional impact on neurite outgrowth. The studies presented in this work were designed to examine MT5-MMP expression in cultured NT2 cells, a model of newogenesis and neuronal differentiation, and in adult neurogenic brain regions. We further sought to overexpress MT5-MMP and test the hypothesis that it plays a role in …

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An Evaluation Of Hospital Capital Investment After The Balanced Budget Act, Tae Hyun Kim Jan 2006

An Evaluation Of Hospital Capital Investment After The Balanced Budget Act, Tae Hyun Kim

Theses and Dissertations

Capital investments in the latest medical equipment and the replacement of aging facilities are important hospital decisions because they may have a significant influence on operating efficiencies and quality of care. However, hospitals experienced a minimal growth rate in capital expenditures which contributed to the aging of the hospital industry's asset base during the late 1990's and early 2000's. One of the underlying reasons behind this lack of growth might be the financial stresses that hospitals were facing after the Balanced Budget Act (BBA) of 1997, which significantly reducedMedicare reimbursement and had an adverse impact on the financial viability of …

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Undone, Julie J. Johnson Jan 2006

Undone, Julie J. Johnson

Theses and Dissertations

My art has become rooted in a process of layering. I layer materials to explore technique and to express the concept of inside versus outside. The evidence of multiple layers of materials is symbolically connected to what is happening within my own life. I want the viewer to see an indication of deeper layers of process and materials rather than just the polished surface of an artwork. This layering process can also be seen as a metaphor for human nature, what we see on the outside is not always what is on the inside.

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Discovery Of Lignin Sulfate As A Potent Inhibitor Of Hsv Entry Into Cells, Jay N. Thakkar Jan 2006

Discovery Of Lignin Sulfate As A Potent Inhibitor Of Hsv Entry Into Cells, Jay N. Thakkar

Theses and Dissertations

The herpes virus family consists of more than hundred members that infect organisms, of which eight, differing markedly in the biology are known to infect humans. HSV- I is the most common one, causing oral lesions and sporadic encephalitis. These infections are highly prevalent affecting at least one in three individuals in the United States.The entry of the herpes virus into the cell is a two-step process. The initial step involves the cell surface heparan sulfate and glycoproteins in the viral envelope which enables the virus to penetrate into the cell. The second step is the fusion step. Depending on …

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Influence Of Anti-Cd44 On Murine B Cell Activation, Tiana L. Wyant Jan 2006

Influence Of Anti-Cd44 On Murine B Cell Activation, Tiana L. Wyant

Theses and Dissertations

Lymphocyte activation and trafficking are indispensable to the immune system. CD44, an adhesion molecule, plays important roles in T cell activation, lymphocyte homing/trafficking, and tumor metastasis. Although the functions of CD44 have been shown in T cells and other leukocytes, little is known about its role in B cells. The effects of CD44 cross-linking on murine B cell activation via CD40L/IL-4 was explored using the anti-CD44 mAbs RK3G9 and IM7. Immobilized RK3G9 and IM7 could strongly inhibit B cell proliferation and Ig production, with IgE inhibition being prominent. Soluble anti-CD44 had no effect. The inhibitory effect of RK3G9 was not …

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