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Full-Text Articles in Entire DC Network
[2010-08-25] Meeting Of The External Relations Committee, Virginia Commonwealth University. Board Of Visitors
[2010-08-25] Meeting Of The External Relations Committee, Virginia Commonwealth University. Board Of Visitors
VCU Board of Visitors Minutes
Official minutes of the VCU Board of Visitors and its Executive Committee.
[2010-08-25] Meeting Of The Finance, Investment And Property Committee, Virginia Commonwealth University. Board Of Visitors
[2010-08-25] Meeting Of The Finance, Investment And Property Committee, Virginia Commonwealth University. Board Of Visitors
VCU Board of Visitors Minutes
Official minutes of the VCU Board of Visitors and its Executive Committee.
Informing Social Work Practice Through The Enhancement Of The Biological Perspective: A Course Intervention Model For Human Service Professionals Working With Youth And Problems Of Conduct., Allison Sampson
Theses and Dissertations
The purpose of this study is to evaluate the effectiveness of an intervention model designed to enhance practitioners’ biological lens when using a biopsychosocial-spiritual model of holistic assessment and planning. The specific intervention utilized is a course curriculum developed to broaden human service professionals’ (including clinical social work professionals) understanding of attachment theory, neuroscience and trauma informed methods of practice. The course teaches professionals how to apply this knowledge to clinical assessment and intervention planning with youth who have experienced significant trauma in their lives and exhibit problems of conduct. Using an experimental design, participants from a large private mental …
Urban Adolescents’ Cognitive Responses To Peer Victimization: Does Psychosocial Adjustment Play A Role?, Amie Bettencourt
Urban Adolescents’ Cognitive Responses To Peer Victimization: Does Psychosocial Adjustment Play A Role?, Amie Bettencourt
Theses and Dissertations
Peer victimization is characterized by acts of physical, relational, and verbal aggression that can contribute to maladjustment. Youths’ responses to peer victimization are guided by social information-processing (SIP) skills that impact their adjustment. Maladjustment can contribute to biases in SIP. Biased processing occurs when youth rely on existing schemas without attending to cues from the immediate social context. These processing deficits contribute to the enactment of problematic responses that may lead to further maladjustment. However, not all youth exhibit SIP deficits. A recent study identified four adjustment clusters based on differences in aggression, anxiety, depression, social acceptance, and victimization within …
Perceptions Of State-Funded, School District-Based Principal Preparation Programs In Virginia 2004-2006, Kathryn Kirk
Perceptions Of State-Funded, School District-Based Principal Preparation Programs In Virginia 2004-2006, Kathryn Kirk
Theses and Dissertations
This mixed methods case study described and analyzed the 2004-2006 district-based principal preparation programs in Virginia. This dissertation explored goals stated in proposals for funding as well as program director and program completer perceptions of goals, content, processes, and outcomes for the 10 principal preparation programs that stemmed from the Commission to Review, Study, and Reform Educational Leadership. Data collection employed three phases: Phase I focused on the 10 grant proposals; Phase II involved semistructured interview questions centered on perceptions of nine participating program directors; Phase III investigated perceptions of 75 program completers who responded to a web-based survey. Data …
Mechanisms Of Rotator Cuff Disease: Alterations Of Scapular Kinematics On Subacromial Space, Amee Seitz
Mechanisms Of Rotator Cuff Disease: Alterations Of Scapular Kinematics On Subacromial Space, Amee Seitz
Theses and Dissertations
Rotator cuff disease is multi-factored and has been attributed to both intrinsic and extrinsic factors. Extrinsic factors contribute to compression of the rotator cuff tendons. Intrinsic factors that contribute to rotator cuff tendon degradation with tensile/shear overload include alterations in biology, mechanical properties, morphology, and vascularity. Subacromial impingement is related to factors that encroach upon the subacromial space, while internal impingement affects the articular side of the tendons adjacent to glenoid. While the mechanisms of impingement are varied, further research is necessary to improve treatment and patient outcomes. Chapter 2 is a thorough review of literature on the mechanisms of …
Cultural Factors And Communication During Medical Consultations With Hiv-Positive Racial/Ethnic Minority Patients, Lillian Stevens
Cultural Factors And Communication During Medical Consultations With Hiv-Positive Racial/Ethnic Minority Patients, Lillian Stevens
Theses and Dissertations
This study examined the relationships between cultural characteristics, communication variables, and medical outcomes in HIV-positive racial/ethnic minority patients. Participants included 33 patients and 5 providers across two urban, community medical clinics. The patient sample was 61% African American, 24% Latino, and 15% Other/Mixed. The majority (73%) were male. Providers included one White female physician, one White male nurse practitioner, two White female nurse practitioners, and one White male physician assistant. In this descriptive study, patients completed self-report ratings of their desire for engagement in decision-making prior to their scheduled medical consultation. After their consultations, patients rated their provider regarding engagement …
Development And Applications Of The Hint Forcefield In Prediction Of Antibiotic Efflux And Virtual Screening For Antivirals, Aurijit Sarkar
Development And Applications Of The Hint Forcefield In Prediction Of Antibiotic Efflux And Virtual Screening For Antivirals, Aurijit Sarkar
Theses and Dissertations
This work was aimed at developing novel tools that utilize HINT, an empirical forcefield capable of quantitating both hydrophobic and hydrophilic (hydropathic) interactions, for implementation in theoretical biology and drug discovery/design. The role of hydrophobicity in determination of macromolecular structure and formation of complexes in biological molecules is undeniable and has been the subject of research across several decades. Hydrophobicity is introduced, with a review of its history and contemporary theories. This is followed by a description of various methods that quantify this all-pervading phenomenon and their use in protein folding and contemporary drug design projects – including a detailed …
Adam10 Is A Critical Regulator Of B Cell Development, Antibody Production, And Myeloid-Derived Suppressor Cell Expansion: Effects Of B Cell-Specific Adam10 Deletion And Overexpression In Vivo., David Gibb
Theses and Dissertations
Proteolytic processing of transmembrane receptors and ligands can have dramatic effects on cell signaling and subsequent cellular responses. Previous studies demonstrated that a disintegrin and metalloproteinase 10 (ADAM10) may cleave numerous B cell-expressed receptors, including the low affinity IgE receptor (CD23). However, lethality of ADAM10-deficient embryos has limited examination of these cleavage events in lymphocytes. To investigate their role in B cell development and function, we generated B cell-specific ADAM10 knockout mice. Intriguingly, deletion prevented development of the entire marginal zone B cell (MZB) lineage. Further analysis revealed that ADAM10 is required for S2 cleavage of the Notch2 receptor and …
Image Processing Algorithms For Diagnostic Analysis Of Microcirculation, Sumeyra Ummuhan Demir
Image Processing Algorithms For Diagnostic Analysis Of Microcirculation, Sumeyra Ummuhan Demir
Theses and Dissertations
Microcirculation has become a key factor for the study and assessment of tissue perfusion and oxygenation. Detection and assessment of the microvasculature using videomicroscopy from the oral mucosa provides a metric on the density of blood vessels in each single frame. Information pertaining to the density of these microvessels within a field of view can be used to quantitatively monitor and assess the changes occurring in tissue oxygenation and perfusion over time. Automated analysis of this information can be used for real-time diagnostic and therapeutic planning of a number of clinical applications including resuscitation. The objective of this study is …
Arterial Waveform Measurement Using A Piezoelectric Sensor, Ruizhi Zhang
Arterial Waveform Measurement Using A Piezoelectric Sensor, Ruizhi Zhang
Theses and Dissertations
This study aims to develop a new method to monitor peripheral arterial pulse using a PVDF piezoelectric sensor. After comparing different locations of sensor placement, a specific sensor wrap for the finger was developed. Its composition, size, and location make it inexpensive and very convenient to use. In order to monitor the effectiveness of the sensor at producing a reliable pulse waveform, a monitoring system, including the PZT sensor, ECG, pulse-oximeter, respiratory sensor, and accelerometer was setup. Signal analysis from the system helped discover that the PZT waveform is relative to the 1st derivative of the artery pressure wave. Also, …
Canopy Disturbance And Reproduction In Cornus Florida L., Daniel Carr
Canopy Disturbance And Reproduction In Cornus Florida L., Daniel Carr
Theses and Dissertations
This study examined aspects of local reproductive variation in the flowering dogwood (Cornus florida L.) coincident with recent differences in primary canopy architecture. The dogwood trees in this study were impacted by a hurricane that created numerous treefall gaps, which created fine scale heterogeneity in the primary canopy. Fine scale disturbances in a forest can result in changes for multiple members of the forest community, including the reproductive responses of the trees and interspecific pollination mutualisms. Previously determined differences in offspring genetic structure suggested that pollen movement among genetically unstructured maternal individuals was significantly impacted between open, or disturbed, canopy …
Adherence To The American College Of Surgeons (Acs) Recommendation On Double Gloving, Hand Free Zone And Blunt Suture Needle Use Among Surgeon Ranks, Akbar Nassiry
Theses and Dissertations
Background: The American College of Surgeons guidelines suggest the use of intact gloves, double gloving, hands-free zone technique to pass sharp instruments, and blunt tip suture needles to protect patients, as well as the surgical team. This study estimates the extent to which these guidelines are followed in a large academic health system. Methods: Over a two-month period in the spring of 2010, 320 general surgical attendings, subspecialty surgical attendings, and surgical resident physicians practicing at a large academic health system, were approached during or after surgical conferences to participate in a cross-sectional study. Nearly 1/3rd completed an anonymous and …
Effect Of Ph On The Transcriptional Profile Of Porphyromonas Gingivalis W83, Nathan Maietta
Effect Of Ph On The Transcriptional Profile Of Porphyromonas Gingivalis W83, Nathan Maietta
Theses and Dissertations
Porphyromonas gingivalis, a gram-negative, anaerobic bacterium, is widely recognized as a causative agent for periodontal disease. Despite sequencing of the complete genome, no research exists examining gene regulation response in P. gingivalis to shifts in pH. Previous studies have shown that P. gingivalis is capable of surviving in the variety of micro- environmental niches found within the oral cavity, including basic and acidic pH conditions. However, the underlying mechanisms of this survival are not well understood. This study examined P. gingivalis by comparing bacteria shocked at three acidic to neutral pH conditions (5.5, 6.5 and 7.0) to bacteria vii shocked …
Cannabinoid Receptors In The 3d Reconstructed Mouse Brain: Function And Regulation, Peter Nguyen
Cannabinoid Receptors In The 3d Reconstructed Mouse Brain: Function And Regulation, Peter Nguyen
Theses and Dissertations
CB1 receptors (CB1R) mediate the psychoactive and therapeutic effects of cannabinoids including ∆9-tetrahydrocannabinol (THC), the main psychoactive constituent in marijuana. However, therapeutic use is limited by side effects and tolerance and dependence with chronic administration. Tolerance to cannabinoid-mediated effects is associated with CB1R adaptations, including desensitization (receptor-G-protein uncoupling) and downregulation (receptor degradation). The objectives of this thesis are to investigate the regional-specificity in CB1R function and regulation. Previous studies have investigated CB1Rs in a subset of regions involved in cannabinoid effects, but an inclusive regional comparison of the relative efficacies of different classes of cannabinoids to activate G-proteins has not …
Real Time 3-D Tracking Of The High Dose Rate Radiation Source Using A Flat Panel Detector, Aditya Bondal
Real Time 3-D Tracking Of The High Dose Rate Radiation Source Using A Flat Panel Detector, Aditya Bondal
Theses and Dissertations
A number of QA procedures have been developed for Breast Brachytherapy treatments, yet none guarantee accurate dose delivery or allow conformation of the actual source position leading to errors sometimes going unnoticed. The objective of this study is to track the exact path the HDR source would follow in real time. The exit radiation of the HDR source was used to image a well defined matrix of markers. The images were acquired using FPD and were processed to obtain projection coordinates while an x-ray calibration image was processed to obtain marker coordinates. Each marker along with its projection represents a …
Environmental Responses Of Two-Component Systems In Streptococcus Sanguinis, Jenishkumar Patel
Environmental Responses Of Two-Component Systems In Streptococcus Sanguinis, Jenishkumar Patel
Theses and Dissertations
The gram-positive bacterium Streptococcus sanguinis is a member of human indigenous oral microbialflora and has long been recognized as a key player in the bacterial colonization of the mouth. S. sanguinis is also the most common viridians streptococcal species implicated in infective endocarditis. Although many studies have focused on two-component systems in closely related Streptococcus species such as S. mutans, S. pneumoniae and S. gordonii; the mechanism of the response regulator in S. sanguinis is still unknown. The ability of S. sanguinis to adapt and thrive in hostile environments suggests this bacterium is capable of sensing and responding to various …
A Profile Of Inner-City Public School Districts: A Comparative Analysis Of U.S. Metropolitan Area Demographics And The Abandonment Of Neighborhood Schools, Belinda Saunders
A Profile Of Inner-City Public School Districts: A Comparative Analysis Of U.S. Metropolitan Area Demographics And The Abandonment Of Neighborhood Schools, Belinda Saunders
Theses and Dissertations
Most departments of education and school boards do not identify nor compile data reasons for public school abandonments. Public schools are anchors, vital components, and “heartbeats” of communities that contribute to the growth or decline of neighborhoods. Despite the influences that public schools have on the development and sustainability of neighborhoods, public school abandonments are increasing. School systems use abandonments to address challenges of poor academic achievements, decreasing budgets, declining enrollments, and deteriorating and underutilized facilities. However, absent from literature are comprehensive data and analyses that identify the number of public school abandonments, their locations, or the contributing factors for …
Volumetric Growth Model Of Human Medulloblastoma In The Nude Mouse Cerebellum, Thomas Gavigan
Volumetric Growth Model Of Human Medulloblastoma In The Nude Mouse Cerebellum, Thomas Gavigan
Theses and Dissertations
Medulloblastoma is the most common brain tumor in children, accounting for 10-20% of primary central nervous system (CNS) neoplasms and approximately 40% of all posterior fossa tumors. It is a highly invasive embryonal neuroepithelial tumor that typically arises in the cerebellar vermis and has a tendency to disseminate throughout the CNS early in its course. The molecular mechanisms of the disease largely remain uncharacterized, as the clinical treatment is still associated with mortality and severe side effects. The development of a clinically relevant in vivo model is important not only to further understand the disease but also to provide a …
Factors Affecting Gingival Excess, Altered Passive Eruption And Recession In The Mandibular Anterior And Premolar Sites, William Bohlen
Factors Affecting Gingival Excess, Altered Passive Eruption And Recession In The Mandibular Anterior And Premolar Sites, William Bohlen
Theses and Dissertations
Abstract FACTORS AFFECTING GINGIVAL EXCESS, ALTERED PASSIVE ERUPTION AND RECESSION IN THE MANDIBULAR ANTERIOR AND PREMOLAR SITES By William F Bohlen, D.M.D. A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science in Dentistry at Virginia Commonwealth University. Virginia Commonwealth University, 2010 Major Director: Thomas Waldrop, DDS, MS Program director, Department of Periodontics, Virginia Commonwealth University AIM: The aim of this study was to determine the factors affecting gingival excess, altered passive eruption and recession. METHODS: 100 subjects were examined clinically and models of their mandible were fabricated. Demographic, periodontal and cast measurements were …
Klf2/Klf4 Double Knock-Out Mouse Embryos Show Cranial Bleeding With Endothelial Disruption Of The Primary Head Vein, Benjamin Curtis
Klf2/Klf4 Double Knock-Out Mouse Embryos Show Cranial Bleeding With Endothelial Disruption Of The Primary Head Vein, Benjamin Curtis
Theses and Dissertations
Krüppel-like factors (KLFs) are a family of 3 Cys2/His2 zinc finger transcription factors with a diverse set of roles in cellular differentiation, cell cycle regulation, tumor suppression, erythropoiesis, angiogenesis, and other processes. During embryonic development, KLF2 has a role in vessel maturation. Adult conditional KLF4 knockout mouse embryos have thickened arterial intima follow vascular injury. Breeding KLF2+/- and KLF4+/- mice resulted in the generation of KLF2/KLF4 double knockout (DKO) embryos. KLF2/KLF4 DKO embryos died by E10.5 with cranial bleeding. Using immunohistochemistry, embryo whole-mounts were examined for differences in gross vascularization between wild-type (WT), KLF2-/- and KLF2/KLF4 (DKO embryonic day 9.5 …
Novel Roles For Reelin In Retinogeniculate Targeting, Cheryl Haner
Novel Roles For Reelin In Retinogeniculate Targeting, Cheryl Haner
Theses and Dissertations
In the developing visual system, the axon of a pre-synaptic cell must be guided to a post-synaptic partner. Retinal ganglion cells (RGCs) in the eye are an excellent model to study this process. Multiple classes exist that respond to specific types of light input, and these project to different destinations in the brain that process distinct types of information. The RGC axons that navigate to the lateral geniculate nucleus (LGN) do so in a class-specific manner. Axons from RGCs that mediate non-image forming functions innervate the ventral LGN (vLGN) and the intergeniculate leaflet (IGL). Axons from RGCs that process image-forming …
Precursors And Risk Factors Associated With The Development Of Traumatic Stress After Childbirth, Jennifer Runnals
Precursors And Risk Factors Associated With The Development Of Traumatic Stress After Childbirth, Jennifer Runnals
Theses and Dissertations
A prospective study of pregnant women was undertaken to provide an estimate of rates of Posttraumatic Stress Disorder after childbirth that takes into account pre-existing trauma; to explore risk factors associated with the development of traumatic stress after birth; and to better understand incidence and risk factors associated with fear of childbirth, which is thought to contribute to postpartum Posttraumatic Stress Disorder. Ninety participants in their last trimester of pregnancy completed questionnaires that included depression, trait anxiety, PTSD, anxiety sensitivity, childbearing fear, and self-efficacy for labor. Four weeks after delivery 73 of these women completed questionnaires concerning delivery, posttraumatic stress …
Assessing Economic And Hrql Burden Of Food Allergy And Anaphylaxis In The U.S., Dipen Patel
Assessing Economic And Hrql Burden Of Food Allergy And Anaphylaxis In The U.S., Dipen Patel
Theses and Dissertations
Background: Food allergy, an abnormal immunologic response to food protein, has an estimated prevalence of 6% in young children and 3.7% in adults in the U.S. The only proven therapy for food allergy is strict elimination of the offending allergens. As a result, caregivers and patients could experience constant anxiety and stress that affects their quality of life. Additionally, food allergy can lead to significant economic impact on the health care system, since severe reactions often lead to ED visits and hospitalizations. Objectives: The first major objective was to determine the economic burden of Food Allergy and Anaphylaxis (FAA) patients …
Investigation And Optimization Of A Solvent / Anti-Solvent Crystallization Process For The Production Of Inhalation Particles, Swati Agrawal
Investigation And Optimization Of A Solvent / Anti-Solvent Crystallization Process For The Production Of Inhalation Particles, Swati Agrawal
Theses and Dissertations
Dry powder inhalers (DPIs) are commonly used to deliver drugs to the lungs. The drug particles used in these DPIs should possess a number of key properties. These include an aerodynamic particle size < 5μm and particle crystallinity for long term formulation stability. The conventionally used micronization technique to produce inhalation particles offers limited opportunities to control and optimize the particle characteristics. It is also known to induce crystalline disorder in the particles leading to formulation instability. Hence, this research project investigates and optimizes a solvent/anti-solvent crystallization process capable of directly yielding inhalation particles using albuterol sulfate (AS) as a model drug. Further, the feasibility of the process to produce combination particles of AS and ipratropium bromide monohydrate (IB) in predictable proportions and in a size suitable for inhalation is also investigated. The solvent / anti-solvent systems employed were water / ethyl acetate (EA) and water / isopropanol (IPA). Investigation and optimization of the crystallization variables with the water / EA system revealed that particle crystallinity was significantly influenced by an interaction between the drug solution / anti-solvent ratio (Ra ratio), stirring speed and crystal maturation time. Inducing a temperature difference between the drug solution and anti-solvent (Tdrug solution > Tanti-solvent) resulted in smaller particles being formed at a positive temperature difference of 65°C. IPA was shown to be the optimum anti-solvent for producing AS particles (IPA-AS) in a size range suitable for inhalation. In vitro aerosol performance of these IPA-AS particles was found to be superior compared to the conventionally used micronized particles when aerosolized from the Novolizer®. The solvent / anti-solvent systems investigated and optimized …
Function And Regulation Of Matrix Metalloproteinase-1 In Glioblastoma Multiforme, Monika Anand
Function And Regulation Of Matrix Metalloproteinase-1 In Glioblastoma Multiforme, Monika Anand
Theses and Dissertations
Glioblastoma Multiforme (GBM) is an aggressive and fatal cancer of the brain. It is characterized with augmented morbidity and elusion to therapies due in part to the incessant infiltration and spread of tumor cells in normal brain. We investigated the function of Matrix metalloproteinase-1, an important enzyme noted to be responsible for invasion in other cancers, in GBM and its regulation by epidermal growth factor receptor (EGFR) signaling. Previous studies from our laboratory demonstrated elevated levels of MMP-1 in GBM. Further studies indicated the involvement of MMP-1 in GBM invasion. The GBM cell lines T98G, U251MG and U87MG were used …
Characterization And Crystallization Of The Mycobacterium Tuberculosis Trmd, Zohal Hamidi
Characterization And Crystallization Of The Mycobacterium Tuberculosis Trmd, Zohal Hamidi
Theses and Dissertations
One third of the world’s population is affected by Tuberculosis (TB), a disease caused by infection with Mycobacterium tuberculosis (MtB). The emergence of multidrug-resistant MtB makes this disease a major public health concern. New agents are needed to treat TB infections in a manner that circumvents existing pathways of resistance. One strategy is to target the organism at the translational level by inhibiting vital modifications of RNA. One gene responsible for these modifications is the tRNA (guanosine-1)-methyltransferase, trmD, which has been shown to be essential in several bacteria. The eukaryotic and bacterial m1G methyltransferases are structurally dissimilar, making this enzyme …
The Impact Of Adolescent Nicotine Exposure On Drug Dependence In Adulthood, Mai Alajaji
The Impact Of Adolescent Nicotine Exposure On Drug Dependence In Adulthood, Mai Alajaji
Theses and Dissertations
Nicotine is one of the first and most commonly abused drugs in adolescence. According to The Center for Disease Control, every day more than 6000 adolescents try their first cigarette and over 3000 of them become daily smokers. Smoking among adolescents is a strong predictor of future drug abuse and dependence in adulthood. A number of studies has suggests that adolescents pre-exposed to nicotine may suffer permanent disruption of the brain’s reward systems through changes in dopamine receptor function. We hypothesize that nicotine exposure during adolescence causes long lasting neurobiological alterations that increase the likelihood of cocaine use in adulthood. …
Role Of Xrcc3 In Acquisition And Maintenance Of Invasiveness Through Extracellular Matrix In Breast Cancer Progression, Siddharth Saini
Role Of Xrcc3 In Acquisition And Maintenance Of Invasiveness Through Extracellular Matrix In Breast Cancer Progression, Siddharth Saini
Theses and Dissertations
Acquisition of invasiveness through extracellular matrix is a crucial characteristic of transition to malignancy in the breast. It was previously shown that Polo-like kinase 1 (PLK-1), a mitotic kinase and genome stability regulator, is involved in acquisition of invasiveness in a breast cell model (HMT-3522 cell line) of pre-invasive to invasive transition. This and other data led to the suggestion that a new class of genes called GISEM for Genome Instability and Extracellular Matrix Invasiveness may exist. Previous lab data show that XRCC3 is found downregulated in progression from preinvasive to invasive phenotype. This led to the hypothesis that XRCC3 …
The Relationship Among Maternal Infant Bonding, Spirituality, And Maternal Perception Of Childbirth Experience, Linda Bennington
The Relationship Among Maternal Infant Bonding, Spirituality, And Maternal Perception Of Childbirth Experience, Linda Bennington
Theses and Dissertations
The beginning of life is an intense experience for both mother and baby and sets the foundation for future interactions. Researchers have theorized that maternal infant bonding begins prenatally and continues on through the postnatal period. Mṻller (1996) examined that process to determine if prenatal bonding was related to postnatal bonding and discovered that there was only a modest correlation between the two. This led to speculation as to what variables, besides prenatal bonding, could influence postnatal bonding. Klaus & Kennell (1976) noted the detrimental effects of a lack of bonding in terms of abuse and attachment disorders and emphasized …