Digital Commons Network^™

The Primary Care Brief Intervention Competency Assessment Tool (Bi-Cat): Examining Reliability And Validity, Arielle Guillod

Dissertations

Within primary care, the Primary Care Behavioral Health (PCBH) model integrates behavioral health services into medical settings through brief, population‑based interventions delivered by behavioral health consultants (BHCs). Although effective performance in this role requires competencies distinct from traditional mental health practice, few psychometrically sound tools exist to assess clinical skills in primary care. The Brief Intervention Competency Assessment Tool (BICAT) is commonly used for this purpose but lacks published evidence supporting its reliability and validity. This dissertation examined the psychometric properties of the BICAT across two studies. Study 1 evaluated factor structure, internal consistency, and construct validity in a heterogeneous …

Llm-As-A-Judge For Infection Prevention And Control And Antimicrobial Resistance Impact: Comparing Three Main Llms Vs. Human Experts' Assessment, Marcello Di Pumpo, Leonardo Villani, Maria Rosaria Gualano, Danilo Buonsenso, Francesca Raffaelli, Daniele Donà, Patrizia Laurenti, Vittorio Maio, Stefania Boccia, Walter Ricciardi

College of Population Health Faculty Papers

BACKGROUND: Large language models (LLMs) are increasingly used to generate health information, yet their reliability as evaluators remains unclear. This study investigated the feasibility of an LLM-as-a-judge methodology in the context of infection prevention and antimicrobial resistance (AMR), comparing automated ratings with human expert benchmarks.

METHODS: We performed a secondary analysis of an expert-annotated dataset of health messages. Three leading LLMs (ChatGPT, Claude, Gemini) independently evaluated the same messages using an adapted DISCERN tool across five domains: information reliability, quality, AMR impact, persuasiveness, and overall score. We utilized descriptive statistics, intra-rater reliability tests, and mixed-effects ordinal regression to analyze divergence …

Different Chitinase Activity In Nutrient-Enriched Multi-Antagonistic Streptomyces Sp. And Trichoderma Sp. Against Root-Knot Nematodes Meloidogyne Sp., Tri Mujoko, Penta Suryaminarsih, Safira Rizka Lestari

Baghdad Science Journal

The threat of root-knot nematodes to horticultural and plantation crops is a grave concern. To combat this issue, using bacteria and fungi as biological control agents is an effective and efficient approach. This research aims to evaluate the efficacy of Streptomyces sp. strains PS23104 and Trichoderma sp. when grown on nutrient-enriched media as a biological control agent for root-knot nematodes Streptomyces sp. PS23104 and Trichoderma sp. were cultured on enriched EKG media with malt extract, glucose nitrate, pure coconut water, and molasses, while potato extract media without nutrient addition served as the control. The findings indicate that both Streptomyces sp. …

Bioactivity Of Chitosan Coated Nanoparticles Biosynthesized Using Yeast Against Hypervirulent Klebsiella Pneumoniae (Hvkp), Sura Alaa Suod, Huda Suhail Abid Al-Hayanni

Baghdad Science Journal

Multidrug-resistant (MDR) bacteria are becoming one of the most pressing problems worldwide and are becoming difficult to treat; therefore, nanotechnology is a promising alternative technology. The current study aimed to biosynthesize chitosan Saccharomyces cerevisiae nanoparticles (ScNPs) and evaluate their antibacterial activity against hypervirulent Klebsiella pneumoniae (HvKp). Five K. pneumoniae isolates from different clinical sources were screened for extended-spectrum beta-lactamase (ESBL) production and virulence tests. ScNPs were synthesized and characterized. The antibacterial activity of ScE and ScNPs was determined. The result showed that five bacterial isolates were confirmed as K. pneumoniae and displayed highly virulent and resistant capabilities, hence classifying them …

Advancing Data-Driven Health Research From The All Of Us Data Training And Engagement Program, Kristi Sadowski, Debran Tarver, Jennifer Burnette, Allissa Dillman, Regina Renfro, Lafrancis Gibson, Kelli Bursey, Laura Bartlett, Nadine Bonds-Bishop, Lisa Connor, Efraín Flores-Rivera, Sarah Joseph, Yuqi He, Margaret Henderson, Savannah L. Kelley, Maletta Payne, Brett Porter, Kimberly Prosper, Melissa Rethlefsen, For Full Author List, See Comments Below

Faculty Research, Scholarly, and Creative Activity

Background: Fulfilling a recognized need in data skills training for academic librarians, the National Library of Medicine and the National Institutes of Health All of Us Research Program collaborated to enhance academic library workers’ skills in biomedical and public health data, as well as their library's research capacity, through the awareness and use of the All of Us Researcher Workbench. Case Presentation: The All of Us Data Training and Engagement Program for Academic Libraries (ALP) blended professional development training, hands-on learning, and peer-to-peer networking that focused on increasing knowledge of the All of Us Researcher Workbench. Activities were designed to …

Application Of Virtual Reality To Alter Sweetness Perception, Serena Wellbelove, John Gieng, Valerie A. Carr, Kate Mcleod, Xi Feng

Faculty Research, Scholarly, and Creative Activity

Regular consumption of excess sugar is linked to nutrition-based diseases, including gut problems, Non-Alcoholic Fatty Liver Disease, and Type 2 Diabetes Mellitus. Increasing sweetness perception is a novel technique to decrease sugar consumption. This experiment compared the sweetness perception of sweetened and unsweetened almond milk in response to different virtual environments with music and visuals. Two music types, the classical song Goldberg Variations, BMV. 998-Variation 13 and a jazz song generated by AI were used. Additionally, fall and spring forest backgrounds were generated by the Blockade Labs 3D image generator. Each participant tasted sweetened and unsweetened almond milk in music-only, …

Investigating The Links Between Parent Math Anxiety, Parenting Behaviors, And Child Math Achievement And Math Anxiety In Middle Childhood, Kimia Akhavein

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Existing research indicates that parents’ math anxiety is a robust predictor of children’s math achievement and math anxiety. The current dissertation study moved the literature forward by examining the transmission of parents’ math anxiety to children’s math achievement and math anxiety via autonomy-supportive and controlling parenting behaviors using an observational coding scheme during a homework help task when children were in second grade. The first research aim examined if parents’ autonomy supportive and controlling behaviors mediated the link between parents’ math anxiety and children’s math achievement and math anxiety one year later. The second research aim examined whether parents’ emotion …

Beyond Static Measures: The Predictive Validity And Classification Accuracy Of A Dynamic Assessment Of Decoding For Early Elementary, Bridgett Bakula

Theses and Dissertations

Early and accurate identification of children at risk for reading difficulty is essential to prevent long-term academic failure, yet traditional static assessments often struggle to distinguish between a true reading disorder and a lack of prior instruction. This is particularly evident in the early grades, where floor effects and cultural/linguistic biases limit the classification accuracy of traditional screeners. This study investigated the predictive validity and structural utility of the modifiability index of a dynamic assessment (DA) of decoding, administered in kindergarten. Unlike static measures that evaluate "already actualized" knowledge, DA measures a student's learning potential and modifiability, or the capacity …

Enhancing Patient Safety: The Impact Of Ehr Modifications On Medication Administration, Ellie Foral, Sarah Kiser, Regine Collier, Courtney Schleder, Cynthia Gamino, Morgan Garrison, Samantha Higdon, Bao Khuat

2025

No abstract provided.

Association Of Calcium-Sensing Receptor (Casr) Gene Polymorphisms With Calcium Stone Disease In Babylon Province, Iraq., Hadi Sajid Abdulabbas, Yasir Haider Al-Mawlah, Aamal Muhsen Kadhum

Baghdad Science Journal

In an effort to identify the polymorphism's ultimate function in calcium stone development, an evaluation of the link between calcium stone disease and CaSR polymorphism in the population of Babylon Province, Iraq, was performed. 60 patients were hospitalized at Hillah Hospital in the province of Babylon. Blood samples were collected between January and December 2020. Sixty patients diagnosed with renal stones and forty healthy controls were included in the study. CaSR single-nucleotide polymorphisms (SNPs) were genotyped using the single-strand conformation polymorphism technique after a polymerase chain reaction. In order to confirm these DNA polymorphisms, DNA sequencing was employed. The findings …

Prevalence Of Torovirus, Rotavirus, And Adenovirus Infection Among Iraqi Pediatric Patients With Gastroenteritis, Eman A. Mahmood, Nadira S. Mohamed, Safaa Al-Deen A. S. Al-Qaysi

Baghdad Science Journal

Gastroenteritis is a major cause of morbidity and mortality among children, particularly in developing countries. Rotavirus, adenovirus, and torovirus are among the common viral agents associated with pediatric gastroenteritis. This study aimed to determine the prevalence of these viruses and to evaluate diagnostic methods for torovirus infection among Iraqi children. A total of 250 stool samples were collected from pediatric patients aged from 2 weeks to over 10 years who attended Children's Protection Teaching Hospital, Baghdad, Iraq, between December 2023 and August 2024. The samples were screened for the presence of rotavirus, enteric adenovirus, and torovirus antigens using the Hemagglutination …

Book Review: Don’T Believe Everything You Think: Why Your Thinking Is The Beginning And End Of Suffering, Monique Salcido

Journal of Social, Behavioral, and Health Sciences

This book review examines a recent publication on how individuals can learn to end negative thinking and spend more time living in abundance, peace, and joy. The review summarizes the central themes, highlights strengths and weaknesses, outlines contributions to mental health literature, and offers recommendations. Particular attention is given to how the author conveys his message, and examples from the book are provided. Although the book has several limitations, the review underlines how it can be incorporated into the mental health field through contributions to clinicians and their clients. Overall, the book provides a beneficial resource for social workers, counselors, …

Expert Opinion: Management Of Intraocular Inflammation And Vasculitis After Intravitreal Pegcetacoplan For Geographic Atrophy, Thomas Albini, Steven Yeh, Carl Regillo, Roy Schwartz, Philip Ferrone, Caroline Baumal, Charles Wykoff

Wills Eye Hospital Papers

BACKGROUND AND OBJECTIVE: This expert opinion review is intended to provide guidelines for diagnosis and management of intraocular inflammation (IOI) and vasculitis following pegcetacoplan.

PATIENTS AND METHODS: A case series of all post-marketing reports classified by experts as definite or suspected vasculitis over an 18-month period was assessed.

RESULTS: A total of 306,000 pegcetacoplan intravit real injections were given in the real world between March 1, 2023, and August 31, 2024. Twenty-four eyes from 22 patients (mean age 76 years, 59% female) with definite or suspected vasculitis were evaluated. Comorbidities included hypertension (55%), hypo thyroidism (27%), and recent COVID-19 infection …

Vamorolone For Duchenne Muscular Dystrophy A Cross-Trial Efficacy Comparison With Classic Corticosteroids From The For-Dmd Trial, Paula R. Clemens, Anders Berglund, Marianela Schiava, Meredith K. James, Michael P. Mcdermott, Katherine Bushby, Erik Lampa, Edward Thomas James Rochford, Leanne M. Ward, Robert C. Griggs, Eric P. Hoffman, Michela Guglieri

Pharmacy Faculty Scholarship

Background and Objectives: Vamorolone demonstrated similar efficacy for Duchenne muscular dystrophy (DMD) compared with prednisone in a 24-week exploratory analysis and may reduce key side effects compared with classic corticosteroids. In this study, we compare the efficacy and anthropometric effect of vamorolone 6 mg/kg/d with prednisone 0.75 mg/kg/d and deflazacort 0.9 mg/kg/d in steroid-naïve boys aged 4 to < 7 years using data from 2 trials. Methods: VISION-DMD was a phase 2b, 48-week randomized, double-blind trial assessing vamorolone 2 and 6 mg/kg/d vs placebo and prednisone 0.75 mg/kg/d to 24 weeks. Finding the Optimum Steroid Regimen for DMD (FOR-DMD) was a double-blind, parallel-group randomized trial comparing daily prednisone 0.75 mg/kg/d, daily deflazacort 0.9 mg/kg/d, and intermittent prednisone 0.75 mg/kg (10/10 days on/off). Entropy balancing generated weighted data for mixed model for repeated measures analyses that compared VISION-DMD vamorolone 6 mg/kg/d efficacy and anthropometric outcomes with FOR-DMD prednisone and deflazacort outcomes at 6 and 12 months. Inclusion criteria were boys with genetically confirmed DMD, age 4 to < 7 years, ambulatory, and able to complete a time-to-stand (TTSTAND) assessment in < 10 seconds at baseline. Results: All interventions showed motor improvements relative to baseline at 6 and 12 months. Using the weighted cohorts and at 12 months, vamorolone 6 mg/kg/d (n = 28) had similar changes in TTSTAND velocity, the primary motor endpoint component in both trials, vs daily prednisone (n = 50) or deflazacort (n = 55; mean baseline age 5.42 years all groups), but with CIs overlapping minimal clinically important thresholds of 0.023 rises per second (TTSTAND velocity least squares mean [LSM] difference [95% CI]: vamorolone 6 mg/kg/d vs prednisone 0.75 mg/kg/d, 0.004 rises per second [−0.025 to 0.032] and vs deflazacort 0.9 mg/kg/d, 0.001 rises per second [−0.027 to 0.028]). Body mass index (BMI) Z-scores increased in all groups, greatest with vamorolone (12-month LSM difference [95% CI]: vamorolone vs prednisone 0.57 [0.24–0.90]; vamorolone vs deflazacort 0.29 [0.03–0.56]), whereas growth slowdown occurred in prednisone- and deflazacort-treated boys but not vamorolone (12-month LSM difference in height Z-scores [95% CI]: vamorolone vs prednisone 0.57 [0.24–0.90]; vamorolone vs deflazacort 0.72 [0.53–0.91]). Discussion: Vamorolone demonstrated numerically similar TTSTAND velocity changes to prednisone and deflazacort at 1 year; however, interpretations of differences are limited by 95% CIs crossing minimally important difference thresholds. Further evidence of the growth-protective effect of vamorolone was observed; however, all treatments increased BMI. Vamorolone provides a linear growth-protective classic corticosteroid alternative.

Distributed Impressions: How Multiple Minds Come Together To Shape Person Perception, Lindsey J. Tepfer

Dartmouth College Ph.D Dissertations

Moments after perceiving another person, we immediately infer a wealth of information about them. Despite the complexities within our social environments, we distill an incredible magnitude of details available to us into compressed representations of other people’s minds and mannerisms. Yet research has focused largely on mapping isolated stimuli—divorced from its messy context—to the spontaneous impressions they provoke. As a result, there are many unanswered questions about how our judgments are influenced by the rich and noisy social world we inhabit. Here, I’ve leveraged two paradigms to investigate how impression formation and updating may operate when the constraints of the …

Mxene-Based Optical Fiber Sensors For Chemical And Biosensing: Review And Perspectives, Chen Zhu, Huaijun Guan, Chenxi Huang, Rex E. Gerald, Jie Huang

Electrical and Computer Engineering Faculty Research & Creative Works

No abstract provided.

Optimizing Orthopedic Outcomes: Correlation Between Postoperative Disposition Planning And Quality Outcomes In Joint Reconstruction Patients, Mahdi Ali, Teresa Latvis Ma, Bsn, Rn, Carissa Hrichak Mba, Bsn, Rn, Ashleigh Solomon, Hannah Fortune Mha

Research Scholars

No abstract provided.

Bridging Pediatric To Adult Care In Cystinosis: A Scoping Review Of Healthcare Transition Of Care Protocols And A Roadmap For Future Practice., Sanat Subhash, Nicholas Pantelakis, Kyle Backston, Ruhaan Bajpai, Amir Safadi, Brandon Petrovich, Bradley A. Warady, Maria Diaz-Gonzalez De Ferris, Rupesh Raina

Manuscripts, Articles, Book Chapters and Other Papers

Cystinosis is a rare lysosomal storage disorder that affects approximately 1 in 100,000 to 200,000 live births worldwide. Long-term graft success in cystinosis depends on cysteamine adherence and structured multidisciplinary transition, supported by protocols developed by both pediatric nephrologists and hospital organizations. This review explores institutional and regional care models, structured programs such as the RISE protocol and Got Transition's Six Core Elements, and major barriers including adult nephrology expertise, psychosocial stressors, and insurance coverage gaps. Additionally, we explore the impact of digital health tools for their role in supporting cysteamine adherence and maintaining continuity of care. Emerging technologies such …

Evaluation Of Cytotoxic Effect From Clinacanthus Nutans Leaf Extract On Mda-Mb231 Cells Expressing Cd44+/Cd24–, Siti Syarifah, Tri Widyawati, Sri Melinda Kaban, Nor Adlin Md Yusoff

Baghdad Science Journal

Breast cancer prevalence and incidence are increasing globally every year. Medication resistance and recurrence are more likely in breast cancer cells that express CD44⁺/CD24^–. C.nutans leaves are a traditional medicinal herb with numerous pharmacological benefits, including antioxidant and antiproliferation properties, although the activity against breast cancer stem cells is still unclear. Method: In this study, C.nutans leaves were extracted using ethanol solvent with graded concentrations of 100%, 80%, 60%, 40%, 20%, and 0% (water), respectively, by maceration. We used isolated MDA-MB231 cells with high expression of CD44⁺/CD24^– by using magnetic-activated cell sorting …

Brief Of Public Health And Health Law Scholars As Amici Curiae Urging Affirmance In Support Of Plaintiffs-Appellees, Rachel L. Zacharias, Zeinab Bakhet, Kevin Costello, Maya Manian

Amicus Briefs & Court Filings

INTRODUCTION: Physicians’ use of their judgment and expertise to prescribe drugs and devices for purposes other than those approved by the Food and Drug Administration (“FDA”)—colloquially known as off-label use—is an indispensable feature of modern medicine. The FDA approves drugs as “safe and effective for specific indications.” Christopher M. Wittich, Christopher M. Burkle & William L. Lanier, Ten Common Questions (and Their Answers) About OffLabel Drug Use, 87 Mayo Clinic Procs. 982, 982 (2012). Federal law then generally leaves prescribing decisions, including off-label use of FDA-approved drugs and devices for a patient’s particular indication, to physicians acting under state law …

Histopathological And Immunological Effects Of Tamanu Oil Nanoemulsion On Imiquimod Induced Psoriasis In Albino Rat Skin, Israa Mahmood Mohammed, Treefa Farouq Ismail

Baghdad Science Journal

Psoriasis is an autoimmune disease caused by T-cell activation. This condition is characterized by skin proliferation and inflammation. This study aimed to enhance tamanu oil bioavailability by green synthesis method, in order to evaluate the potential anti-psoriatic benefits of tamanu oil nanoemulsion in rat skin, based on observational, histopathological, and immunological outcomes. The formulation was prepared by phase inversion temperature technique. The physical and chemical characteristics include: droplet morphology, size, zeta potential, pH, and stability. The formulation exhibited a spherical and small globule size of less than 100 nm, good zeta potential (–23.9 mV), suitable pH (5.3) and physically stable. …

Cytokine Profiles In Rheumatoid Arthritis: Relationship Of Tnf-Α , Il-17, And Il-13 With Autoantibodies (Rf And Anti-Ccp) And Clinical Disease Severity, Sonia Elia Ishaq, Taban Kamal Rasheed, Niaz Albarzingi

Baghdad Science Journal

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation and autoantibody production. This study aimed to assess serum levels of TNF-α , IL-17, and IL-13 in RA patients and to explore their association with disease severity and autoantibody status in comparison to healthy controls. The study involved 67 RA patients and 20 healthy individuals. Patients were initially classified based on autoantibody status (RF-positive vs. RF-negative and anti-CCP-positive vs. anti-CCP-negative), and further categorized into low, moderate, and high disease activity groups. Cytokine levels were measured by ELISA, CRP and RF by turbidimetry, and anti-CCP levels by electrochemiluminescence immunoassay. …

Foliar Application Of Methyl Jasmonate And Titanium Nanoparticles Mitigates The Negative Effects Of Salinity On Lettuce Plants, Tahani J. Hijazin

Baghdad Science Journal

Salinity stress is one of the major abiotic factors that significantly impact plant growth. In this regard, this work investigated a way to alleviate the adverse impacts by simultaneously spraying methyl jasmonate and titanium nanoparticles on lettuce (Lactuca sativa L.) plants, which are grown under induced salinity conditions. Two concentrations of salt (100 and 150 mM NaCl) were applied to the plants. After that, simultaneous spraying of methyl jasmonate (0.5 and 1 mM) and titanium nanoparticles (100 and 200 mg/L) was performed on lettuce leaves. Following the application of the previous treatments, the plants were collected, and various …

Effects Of Modified Cryoprotectants On The Expression Of Heat Shock Protein 90 (Hsp90) And Zona Pellucida Ii (Zpii) Of Post-Thawing Sperm Quality, Silvia Werdhy Lestari, Manggiasih Dwiayu Larasati, Gita Pratama, Mulyoto Pangestu, Muhammad Thoriq, Dantha Rafael Sitompul

Baghdad Science Journal

Sperm cryopreservation is a basic element of assisted reproductive technology, yet it often compromises cell viability through thermal and osmotic stress. The cellular response involves HSP90, a stress marker and ZPII, which is essential for sperm-oocyte interaction and preventing polyspermy. In addition, this modified cryoprotectant combines glycerol and raffinose is expected to reduce damage and increase spermatozoa's recovery rate after cryopreservation. To address these challenges, we investigated the expression levels of HSP90 and ZPII to assess the protective capacity of modified cryoprotectant formulations. These parameters were analyzed pre- and post-cryopreservation to establish whether these novel mediums superiorly preserve sperm integrity …

Beyond Sticky Floors: Executive Gender Diversity And Firm-Level Gender Pay Inequality In Uk Firms, Yasser Eliwa, Sally Ahmed, Ahmed Saleh

All Works

This study examines whether executive gender diversity is associated with gender pay inequality in UK firms. Although prior research has extensively examined board diversity, less is known about whether gender diversity within executive leadership teams is linked to differences in pay inequality across firms. Using a panel of FTSE 350 non-financial firms from 2017 to 2023 and mandatory UK gender pay gap disclosures, we estimate regression models to examine the relationship between the proportion of female executives and the gender pay gap. The findings show that greater executive gender diversity is significantly associated with lower gender pay inequality. In contrast, …

Dabrafenib-Induced Cutaneous Eruptions In A Patient With Langerhans Cell Histiocytosis, Jaanvi Mehta, Julianna Tolotta, Eleanor Matthews, Daniel Joffe, Safiyyah Bhatti, Lauren Banner, Jenna Mandel, Molly Wallace, Timothy G. Webster, Jason B. Lee, Neda Nikbakht

Department of Dermatology and Cutaneous Biology Faculty Papers

Langerhans cell histiocytosis (LCH) is a rare malignancy marked by clonal proliferation of Langerhans cells, with BRAF V600E mutations identified in over 50% of the cases. BRAF inhibitors (BRAFi), such as dabrafenib, have shown efficacy in treating BRAF V600E-mutant LCH. However, BRAFi therapy is associated with cutaneous adverse effects, including the development of new melanocytic nevi, verrucae, and keratinocyte carcinoma (KC). This case report describes a 78-year-old woman with BRAF V600E-mutant LCH who developed multiple dermatologic side effects following dabrafenib salvage therapy. Seven weeks into treatment, the patient presented with eruptive palmoplantar nevi, verrucae, and a basal cell carcinoma (BCC). …

Fostering Collaboration Through Learning Communities: A Case Report On Engaging With All Of Us Data Among Library Professionals, Faculty, And Students, Zachary Mcniece, Dawn Hackman, Nick Szydlowski, Yuqi He

Faculty Research, Scholarly, and Creative Activity

Background: Research data services (RDS) have expanded in academic libraries but can be challenging to develop, particularly in teaching-intensive and less-resourced institutions. Learning communities offer a promising model for building skills, fostering collaboration, and aligning services with local needs. Case Presentation: This case report describes the development and implementation of three learning communities—a library group, a faculty group, and a student group—at a teaching-focused institution. These communities brought together library professionals, faculty, and students from diverse disciplines—including health sciences, education, data science, and engineering—to collaboratively explore the All of Us dataset. By working with the same dataset, participants were able …

Combining Menin And Mek Inhibition To Target Poor Prognosis Kmt2a-Rearranged Ras Pathway-Mutant Acute Myeloid Leukemia., Nastassja Scheidegger, Constanze Schneider, Gabriela Alexe, Yi-Cheng Wang, Todd A. Alonzo, Allen Basanthakumar, Wallace A. Bourgeois, Julia Dudkiewicz-Garbicz, Delan Khalid, Lucy A. Merickel, Jennifer A. Perry, Rhonda E. Ries, Silvi Salhotra, Audrey Taillon, Alan S. Gamis, Richard Aplenc, Marian H. Harris, Mark Wunderlich, Scott A. Armstrong, Jessica A. Pollard, Soheil Meshinchi, Yana Pikman, Kimberly Stegmaier

Manuscripts, Articles, Book Chapters and Other Papers

KMT2A-rearranged (KMT2A-r) acute leukemias are especially prevalent in the pediatric population. KMT2A-fusion proteins drive leukemogenic gene expression through an interaction with a chromatin complex that includes the scaffold protein menin, giving rise to aggressive acute leukemias. RAS pathway mutations are also common in pediatric leukemia. In a cohort of 1750 patients enrolled on Children's Oncology Group (COG) trials, we identified RAS pathway mutations in 43% of acute myeloid leukemia (AML) cases. The presence of RAS pathway mutations in KMT2A-r AML was associated with a lower complete remission rate, poor event-free survival and overall survival (OS), and early relapses. Given the …

Mcguire Memorial V. Teamsters Local 261, International Brotherhood Of

2026 Decisions

USDC for the Western District of Pennsylvania

Promises Fulfilled: 114-Year-Old Alelia Murphy’S Life Of Faith And Resilience, Jacqueline B. Koonce

The Journal of Faith, Education, and Community

Alelia Murphy was the oldest living person in the United States, turning 114 in July 2019 until her death in November 2019. She and her family credit her longevity to her faith in God. This premise is explored through her words as she stated she had not seen everyone she needed to see and compared that statement to Simeon from the Bible who did not die until he saw the Messiah. Alelia Murphy also had not seen everything. She was seeing the relative success of her much admired, former President Barack Obama, and she had just met me, her great …