Digital Commons Network^™

Barriers To Inclusive Deliberation And Democratic Governance Of Genetic Technologies At The Science-Policy Interface, Cynthia Taylor, Bryan Dewsbury

Biological Sciences Faculty Publications

Advances in 21st century genetic technologies offer new directions for addressing public health and environmental challenges, yet raise important social and ethical questions. Though the need for inclusive deliberation is widely recognized, institutionalized risk definitions, regulation standards, and imaginations of publics pose obstacles to democratic participation and engagement. This paper traces how the problematic precedents set by the 1975 Asilomar Conference emerge in contemporary discussions on CRISPR, and draws from a recent controversy surrounding field trial releases of genetically modified mosquitoes to explicate the ways in which these precedents undermine efforts to engage publics in decisions at the science-policy interface.

Comparing The Efficiency Of Nursery And Direct Transplanting Methods For Restoring Endangered Corals, Graham E. Forrester, Maggie Chan, Dennis Conetta, Russell Dauksis, Katie Nickles, Alicia Siravo

Natural Resources Science Faculty Publications

Restoration of plants, corals, and other sessile species often involves transplanting individuals to sites chosen for rehabilitation. Transplanted individuals are sometimes harvested directly from wild populations (direct transplanting), and sometimes propagated or cultured in a “nursery” before being transplanted (nursery outplanting). The ecological effectiveness and cost-efficiency of these methods have rarely been compared, so we performed an experiment to address this. Coral fragments, Acropora cervicornis (n = 780), were collected and assigned to one of three treatments: 1) directly transplanted to a restoration site and placed loose on the reef; 2) directly transplanted and manually attached to the reef; 3) …

Connectivity And Nitrate Uptake Potential Of Intermittent Streams In The Northeast Usa, Kelly Addy Lowder, Arthur Gold, Molly K. Welsh, Pete August, Mark Stolt, Clay P. Arango, Peter M. Groffman

Natural Resources Science Faculty Publications

Non-perennial streams dominate the extent of stream networks worldwide. Intermittent streams can provide ecosystem services to the entire network—including nitrate uptake to alleviate eutrophication of coastal waters—and are threatened by lack of legal protection. We examined 12 intermittent streams in the temperate, humid climate of the Northeast USA. Over 3 years of monitoring, continuous flow was observed a median of 277 d yr⁻¹, with no-flow conditions from early summer into fall. Estimated median discharge was 2.9 L s⁻¹ or 0.36 mm d⁻¹. All intermittent streams originated from source wetlands (median area: 0.27 ha) and the …

Atlantic Meridional Overturning Circulation: Observed Transport And Variability, Eleanor Frajka-Williams, Isabelle J. Ansorge, Johanna Baehr, Harry L. Bryden, Maria Paz Chidichimo, Stuart A. Cunningham, Gokhan Danabasoglu, Shenfu Dong, Kathleen A. Donohue, Shane Elipot, Patrick Heimbach, N. Penny Holliday, Rebecca Hummels, Laura C. Jackson, Johannes Karstensen, Matthias Lankhorst, Isabela A. Le Bras, M. Susan Lozier, Elaine L. Mcdonagh, Christopher S. Meinen, Herlé Mercier, Bengamin I. Moat, Renellys C. Perez, Christopher G. Piecuch, Monika Rhein, Meric A. Srokosz, Kevin E. Trenberth, Sheldon Bacon, Gael Forget, Gustavo Goni, Dagmar Kieke, Jannes Koelling, Tarron Lamont, Gerard D. Mccarthy, Christian Mertens, Uwe Send, David A. Smeed, Sabrina Speich, Marcel Van Den Berg, Denis Volkov, Chris Wilson

Graduate School of Oceanography Faculty Publications

The Atlantic Meridional Overturning Circulation (AMOC) extends from the Southern Ocean to the northern North Atlantic, transporting heat northwards throughout the South and North Atlantic, and sinking carbon and nutrients into the deep ocean. Climate models indicate that changes to the AMOC both herald and drive climate shifts. Intensive trans-basin AMOC observational systems have been put in place to continuously monitor meridional volume transport variability, and in some cases, heat, freshwater and carbon transport. These observational programs have been used to diagnose the magnitude and origins of transport variability, and to investigate impacts of variability on essential climate variables such …

Boat Anchoring Contributes Substantially To Coral Reef Degradation In The British Virgin Islands, Rebecca L. Flynn, G E. Forrester

Natural Resources Science Faculty Publications

Community decline is often linked to anthropogenic activities. Coral reef declines, for example, have been linked to overfishing and climate change, but impacts of coastal development, pollution, and tourism have received increasing attention. Here, we isolated the impact of one little-studied aspect of recreational activity on coral reefs—damage from boat anchoring—by performing a survey of 24 sites in the British Virgin Islands (BVI) subject to varying levels of anchoring activity. The percent cover of hard corals and sea fans was reduced by a factor of ∼1.7 and ∼2.6 respectively at highly anchored sites. Hard coral colonies were 40% smaller in …

Dna Repair Enzymes Alkbh2, Alkbh3, And Alkb Oxidize 5-Methylcytosine To 5-Hydroxymethylcytosine, 5-Formylcytosine And 5-Carboxylcytosine In Vitro, Ke Bian, Stefan Ap Lenz, Qi Tang, Fangyi Chen, Rui Qi, Marco Jost, Catherine L. Drennan, John M. Essigmann, Stacey D. Wetmore, Deyu Li

Biomedical and Pharmaceutical Sciences Faculty Publications

5-Methylcytosine (5mC) in DNA CpG islands is an important epigenetic biomarker for mammalian gene regulation. It is oxidized to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) by the ten-eleven translocation (TET) family enzymes, which are α-ketoglutarate (α-KG)/Fe(II)-dependent dioxygenases. In this work, we demonstrate that the epigenetic marker 5mC is modified to 5hmC, 5fC, and 5caC in vitro by another class of α-KG/Fe(II)-dependent proteins—the DNA repair enzymes in the AlkB family, which include ALKBH2, ALKBH3 in huamn and AlkB in Escherichia coli. Theoretical calculations indicate that these enzymes may bind 5mC in the syn-conformation, placing the methyl group comparable …

Interpretation Of The Individual Effect Under Treatment Spillover, Forrest W. Crawford, Morozova, Ashley L. Buchanan, Donna Spiegelman

Pharmacy Practice and Clinical Research Faculty Publications

Some interventions are intended to benefit both individuals and the groups to which they belong. When a treatment given to one person exerts a causal effect on others, the treatment is said to exhibit spillover, dissemination, or interference. However, defining meaningful causal effects under spillover can be challenging. In this commentary, we discuss the meaning of the “individual effect,” a quantity proposed to summarize the effect of treatment on the person who receives it, when spillover may be present.

Curricular Report No. 2018-19-13 From The Graduate Council To The Faculty Senate (Courses), University Of Rhode Island Faculty Senate

Faculty Senate Bills

No abstract provided.

Faculty Senate Meeting Minutes May 2, 2019, University Of Rhode Island Faculty Senate

Faculty Senate Meeting Minutes

No abstract provided.

Elevating The Environment Through Artistic Expression, Becky Gumbrewicz

Senior Honors Projects

REBECCA GUMBREWICZ (Environmental Science and Management)

Elevating the Environment Through Artistic Expression

Sponsor: Judith Swift (Communication Studies, Coastal Institute)

Currently there are multiple areas of environmental concern that require not only scientific research but increased public awareness in order to motivate further action toward preservation of our environment or remediation of human impacts. To promote a broader perspective of the most effective ways to communicate science, this project offers the culmination of an environmentally-focused art showcase of student interpretations of science that one could posit elevated public perception of the environment. An integral part of conducting research is understanding how …

Acute Promyelocytic Leukemia: A Case Study Correlating Cytogenetic Abnormality With Prognosis, Alyssa Lamond, Theresa Tellier-Castellone

Senior Honors Projects

Advancements in medical technology today have positively impacted the diagnosis, treatment, and prognosis of cancers. Particularly acute promyelocytic leukemia (APL) has completely improved from having the poorest prognosis to one of the best. Acute promyelocytic leukemia is a malignant disease of hematopoietic tissue classified by WHO as leukemia with >20% blasts from the myeloid lineage, specifically promyelocytes. Determined in 1976, FAB classified AML subtypes M1-M7, with APL being M3. Specific characteristics classify the subtype of AML, with each resulting from a different genetic abnormality. The focus of APL diagnosis, treatment, and prognosis occurs around the known PML-RARα fusion gene. Flow …

Integration Of Native American Medicinal Plants Into The Heber W. Youngken Jr. Garden, Emily Lyn Murray

Senior Honors Projects

Healthcare among Native American tribes was focused on all aspects of a patient’s life, such as physical, spiritual, and environmental elements. Healthy outcomes were obtained by maintaining a balance among all of these components. This “bio-psycho-socio-spiritual” approach to healthcare was thought to not only play a role in the health of a certain individual, but the health of the tribe as a whole. An illness was not only precipitated by a physical source, but by an imbalance of these components. Medicinal plants served as an integral role in direct physical healing, as well as an important element for the execution …

Do Metabolic Networks Follow A Power Law? A Psamm Analysis, Ryan Geib, Lubos Thoma, Ying Zhang

Senior Honors Projects

Inspired by the landmark paper “Emergence of Scaling in Random Networks” by Barabási and Albert, the field of network science has focused heavily on the power law distribution in recent years. This distribution has been used to model everything from the popularity of sites on the World Wide Web to the number of citations received on a scientific paper. The feature of this distribution is highlighted by the fact that many nodes (websites or papers) have few connections (internet links or citations) while few “hubs” are connected to many nodes. These properties lead to two very important observed effects: the …

Spatially Explicit Network Analysis Reveals Multi‐Species Annual Cycle Movement Patterns Of Sea Ducks, Juliet S. Lamb, Peter W. C. Paton, Jason E. Osenkowski, Shannon S. Badzinski, Alicia M. Berlin, Tim Bowman, Chris Dwyer, Luke J. Fara, Scott G. Gilliland, Kevin Kenow, Christine Lepage, Mark L. Mallory, Glenn H. Olsen, Matthew C. Perry, Scott A. Petrie, Jean‐Pierre L. Savard, Lucas Savoy, Michael Schummer, Caleb S. Spiegel, Scott R. Mcwilliams

Natural Resources Science Faculty Publications

Conservation of long‐distance migratory species poses unique challenges. Migratory connectivity, that is, the extent to which groupings of individuals at breeding sites are maintained in wintering areas, is frequently used to evaluate population structure and assess use of key habitat areas. However, for species with complex or variable annual cycle movements, this traditional bimodal framework of migratory connectivity may be overly simplistic. Like many other waterfowl, sea ducks often travel to specific pre‐ and post‐breeding sites outside their nesting and wintering areas to prepare for migration by feeding extensively and, in some cases, molting their flight feathers. These additional migrations …

Modernizing Habitat Suitability Indices (Hsi): A Northern Diamondback Terrapin Case Study, Hannah K. Dallas

Senior Honors Projects

Northern diamondback terrapins (Malaclemys terrapin terrapin) are a state-endangered species in Rhode Island and is the only species of northeastern turtle that lives in brackish water. Although their conservation status varies by state, terrapins are primarily negatively impacted by anthropogenic factors such as hunting and habitat loss. To improve conservation, management, and restoration efforts for this species, we developed a new habitat suitability index (HSI) for diamondback terrapins, but with a modern twist.

Habitat suitability indices were first developed by the US Fish and Wildlife Service in 1974 as part of their habitat evaluation procedures (HEP) to predict …

Nanopore Sensing For Single-Molecule Glycomics, Melissa Morris

Senior Honors Projects

Single-molecule sensing represents the ultimate in chemical sensitivity, but is tremendously challenging to achieve. Larger proteins have a diameter of 10 nm, which is 1/10,000^th the size of a strand of hair, and 1/100,000^th the size of a grain of sand. Because imaging at the nanoscale is difficult and expensive, developing techniques to measure single molecules requires ingenuity, and often relies on the interpretation of electrical signals. So how do nanopores help us measure at the single-molecule level?

A nanopore is simply a nano-sized hole in a membrane or material. In the early stages of nanopore science, biological …

Correlation Between Sei Whale Distribution And Chlorophyll-A Concentration In The Western North Atlantic, Dawn Parry

Senior Honors Projects

The sei whale (Balaenoptera borealis) is an endangered baleen whale species whose distribution and migratory movements are poorly understood. Sei whale populations were decimated by commercial whaling in the 19th and 20th centuries. Much of what is currently known about their distributions comes from historical whaling records. Visual sightings, which may be sporadic and limited by weather and access to remote locations, are the primary source of data for recent research. It is thought that sei whale distributions may be influenced by the distribution of their food, which consists of zooplankton (small crustaceans, like shrimp), small fish, and …

An Analysis Of Providers’ Perceived Barriers To Contraceptive Access And Reproductive Healthcare, Ashley Weadick

Senior Honors Projects

The field of Reproductive Healthcare covers nearly every aspect of women’s health. Even during non-reproductive years, Reproductive Healthcare is important for women because it provides medical care often essential to their lives before and after child-bearing years. Contraception is needed by many women before they wish to have children, and after they have any children they choose to have, they may again wish to use contraception or they may require help with postpartum care. One of many reasons why Reproductive Healthcare is so important is because it explains the wide array of options available when it comes to methods of …

Curricular Report No. 2018-19-12 From The Graduate Council To The Faculty Senate: Curricular Changes, University Of Rhode Island Faculty Senate

Faculty Senate Bills

No abstract provided.

Curriculum And Standards Committee Report #2018-19-12: Curricular Changes, University Of Rhode Island Faculty Senate

Faculty Senate Bills

No abstract provided.

Transcriptomic Response To Feeding And Starvation In A Herbivorous Dinoflagellate, Ewelina T. Rubin, Shu Cheng, Amanda L. Montalbano, Susanne Menden-Deuer, Tatiana A. Rynearson

Graduate School of Oceanography Faculty Publications

Grazing by heterotrophic protists influences plankton population dynamics, community composition, and the flux of carbon through marine planktonic food webs. To gain insight into the molecular underpinnings of grazing in dinoflagellates, a group of important heterotrophic protists, we used a RNA-Seq approach to investigate the transcriptomic response of Oxyrrhis marina under fed and starved conditions with three different phytoplankton prey (Isochrysis galbana and two strains of Heterosigma akashiwo). In response to fed and starved conditions, 1,576 transcripts were significantly differentially expressed in O. marina. Fed O. marina cells upregulated transcripts involved in the synthesis of essential fatty …

Surveying Apicomplexan Diversity And Dynamics In Narragansett Bay, Evelyn Spencer

Senior Honors Projects

Parasites play an important role in marine ecosystems and their diversity is generally understudied. Apicomplexans, a group of parasitic protists in the phylum Alveolata, infect a wide variety of animal hosts and are abundant in ecosystems spanning from Polar Regions to Neotropical rainforests. Previous data generated from marine sediments in Antarctica, Naples Bay, and off the coast of Oslo, exhibit high diversity and numbers of apicomplexans. Abundance and diversity of these protists are unknown for Narragansett Bay, despite the fact that they infect many commercially important species. The aim of my study was to obtain abundance data and understand genetic …

The Characterization Of A New Metabolite From A Trichodesmium Bloom, Kelly M. Mcmanus

Senior Honors Projects

Our laboratory has been investigating blooms of Trichodesmium, a genus of ecologically important, nitrogen-fixing cyanobacteria, collected from Padre Island in the Gulf of Mexico. Trichodesmium species are an underexplored biological source of cyanobacteria – a taxa that has been shown to produce chemically diverse secondary metabolites. With our focus on the isolation and structure characterization of new bioactive marine natural products, our research group has discovered over 25 new-to-science compounds over the past three years from these blooms. UV and mass spectrometry-guided isolation of Trichodesmium chromatography fractions were utilized to isolate a new metabolite. Isolation of this metabolite was …

Developing A Modern Microbiology Laboratory Manual To Enhance Student Learning, Alexander Yonchak

Senior Honors Projects

My project has been addressing the issue of incorporating recent developments in biosafety and pedagogical approaches for lab-courses into our existing educational curriculum by developing a new, modern lab manual aimed at improving experiential learning for introductory microbiology teaching labs. Through researching the most recent safety regulations, industry standards, & guidelines for such teaching labs, my manual clearly delineates learning outcomes to match the skills expected of undergraduates completing degrees within the life sciences. In addition, the lab manual that I have designed has been modernized to incorporate the most recent recommended safety precautions and is written in a user-friendly …

Validating The Kubinyi Et Al. Personality Scale In Shelter Dogs, Gianna Zavota

Senior Honors Projects

The aim of this study was to apply the dog personality scale used in the study, Dog and owner demographic characteristics and dog personality trait associations, (Kubinyi et al. 2009) to resident shelter dogs. The personality was originally developed and adapted for dog personality based on a 48 item Human Personality Inventory available from The Big Five. In the study, owners were asked to characterize their dogs using this scale, and in this study a researcher used the scale to characterize dogs at various animal shelters. The four main personality traits measured were calmness, boldness, trainability, and dog …

Juggling Junior Year: The Junior Leadership Experience, Natascha Borgstein

Senior Honors Projects

In 2017, the Center for Student Leadership Development (CSLD) piloted a program entitled Sophomore Breakthrough Experience as an incentive for students to become interested in leadership and pursue a leadership minor. Along with the specific Freshman year and Senior year courses and programs that were already offered by the CSLD, Junior year was then the only year without a main CSLD event. Therefore, I helped design and execute a program specifically for the Juniors at URI. For many students, Junior year represents a shift in focus that can be especially stressful. Many important decisions need to be made and skills …

The Global High Frequency Radar Network, Hugh Roarty, Thomas Cook, Lisa Hazard, Doug George, Jack Harlan, Simone Cosoli, Lucy Wyatt, Enrique Alvarez Fanjul, Eric Terrill, Mark Otero, John Largier, Scott Glenn, Naoto Ebuchi, Brian Whitehouse, Kevin Bartlett, Julien Mader, Anna Rubio, Lorenzo Corgnati, Carlo Mantovani, Annalisa Griffa, Emma Reyes, Pablo Lorente, Xavier Flores-Vidal, Kelly Johanna Saavedra-Matta, Peter Rogowski, Siriluk Prukpitikul, Sang-Ho Lee, Jian-Wu Lai, Charles-Antoine Guerin, Jorge Sanchez, Birgit Hansen, Stephan Grilli

Ocean Engineering Faculty Publications

Academic, government, and private organizations from around the globe have established High Frequency radar (hereinafter, HFR) networks at regional or national levels. Partnerships have been established to coordinate and collaborate on a single global HFR network (http://global-hfradar.org/). These partnerships were established in 2012 as part of the Group on Earth Observations (GEO) to promote HFR technology and increase data sharing among operators and users. The main product of HFR networks are continuous maps of ocean surface currents within 200 km of the coast at high spatial (1–6 km) and temporal resolution (hourly or higher). Cutting-edge remote sensing technologies …

The Role Of Head Trauma In Emotion Dysregulation Among Victims Of Partner Violence, Aleksandra Fryc

Senior Honors Projects

The project I completed explores the relationship between head trauma and emotion dysregulation, or the inability to modulate the intensity and/or duration of emotional responses in a flexible manner in order to meet individual goals and situational demands (Gratz & Roemer, 2004), among victims of domestic violence. The rationale and importance of the project included the possibility that the findings of this study can inform future research in topics including head trauma, emotion dysregulation, and domestic violence. Despite evidence linking emotion dysregulation to both domestic violence and head trauma, no investigations to date have examined whether head trauma stemming from …

Bridging The Molecular/Material Divide: An Investigation Into The Properties Of Polyesters, Terra Marie M. Jouaneh

Senior Honors Projects

By definition, polymers consist of large molecules composed of small, repeating units called monomers. These monomers give characteristic material properties to polymers, whether they be the melting point, the folding character, or the inherent stability. Many of the objects we encounter on a daily basis are composed of polymers. These polymers may be synthetic, such as the plastic in disposable bags, or natural, like glycogen in the liver. Recent developments in biotechnology have used synthetic polymers in drug delivery, contact lenses, and even organ transplants. Polyesters, in particular, have been utilized pharmacologically due to their biodegradable properties. Understandably, not all …

The Role Of Dreams, Intuition, And Social Influences On Conscious Decision-Making Processes, Robert Bouffard

Senior Honors Projects

The average person makes approximately 35,000 conscious decisions per day, which, accounting for the daily amount of sleep a person gets, is equivalent to a decision madeevery two seconds. Upon realizing the frequency, I sought to find a distinctive connectionbetween the conscious and unconscious when it pertains to how people make decisions. I hypothesized that people make decisions regarding their personal relationships with the help of intuition, which I considered to be the ultimate link between our dreams and our conscious thought. I also believed the concept of intuition was entirely dependent on our processing and decoding of dreams. In …