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Articles 811 - 840 of 6794
Full-Text Articles in Entire DC Network
Acceptance And Commitment Therapy Plus Usual Care For Improving Quality Of Life In People With Motor Neuron Disease (Commend): A Multicentre, Parallel, Randomised Controlled Trial In The Uk, Rebecca L. Gould, Christopher J. Mcdermott, Benjamin J. Thompson, Charlotte V. Rawlinson, Matt Bursnall, Mike Bradburn, Pavithra Kumar, Emily J. Turton, David A. White, Marc A. Serfaty, Christopher D. Graham, Lance M. Mccracken, Laura H. Goldstein, Ammar Al-Chalabi, Richard W. Orrell, Tim Williams, Rupert Noad, Idris Baker, Christina Faull, Thomas Lambert, Suresh K. Chhetri, John Ealing, Anthony Hanratty, Aleksandar Radunovic, Nushan Gunawardana, Gail Meadows, George H. Gorrie, Tracey Young, Vanessa Lawrence, Cindy Cooper
Acceptance And Commitment Therapy Plus Usual Care For Improving Quality Of Life In People With Motor Neuron Disease (Commend): A Multicentre, Parallel, Randomised Controlled Trial In The Uk, Rebecca L. Gould, Christopher J. Mcdermott, Benjamin J. Thompson, Charlotte V. Rawlinson, Matt Bursnall, Mike Bradburn, Pavithra Kumar, Emily J. Turton, David A. White, Marc A. Serfaty, Christopher D. Graham, Lance M. Mccracken, Laura H. Goldstein, Ammar Al-Chalabi, Richard W. Orrell, Tim Williams, Rupert Noad, Idris Baker, Christina Faull, Thomas Lambert, Suresh K. Chhetri, John Ealing, Anthony Hanratty, Aleksandar Radunovic, Nushan Gunawardana, Gail Meadows, George H. Gorrie, Tracey Young, Vanessa Lawrence, Cindy Cooper
Peninsula Medical School
Background: Motor neuron disease is a progressive, fatal neurodegenerative disease for which there is no cure. Acceptance and Commitment Therapy (ACT) is a psychological therapy incorporating acceptance, mindfulness, and behaviour change techniques. We aimed to evaluate the effectiveness of ACT plus usual care, compared with usual care alone, for improving quality of life in people with motor neuron disease. Methods: We conducted a parallel, multicentre, two-arm randomised controlled trial in 16 UK motor neuron disease care centres or clinics. Eligible participants were aged 18 years or older with a diagnosis of definite or laboratory-supported probable, clinically probable, or possible familial …
Outcome Measures In Psychiatry, Rohit Shankar
Outcome Measures In Psychiatry, Rohit Shankar
Peninsula Medical School
Measuring what medical care does to improve the lives of patients must be at theheart of what we do (Ryland, Carlile and Kingdon, 2021). A crucial part of achievingthe ambition of parity between physical and mental health is for psychiatry to embrace,use and promote outcome measures as a way of demonstrating the positive impactthat well-resourced and structured mental health services can have for patients, theirfamilies, and society more widely.The Royal College of Psychiatrists strongly endorses and recommends the routine useof patient- and clinician-rated outcome measures in psychiatric practice (Tracy et al.,2022). Outcome measurement can improve care planning, progress-tracking, qualityimprovement, service …
Endotoxin, A Novel Biomarker For The Rapid Risk Assessment Of Faecal Contamination Of Coastal And Transitional Waters, Christian R. Good, Alistair White, Joao Brandao, Simon Jackson
Endotoxin, A Novel Biomarker For The Rapid Risk Assessment Of Faecal Contamination Of Coastal And Transitional Waters, Christian R. Good, Alistair White, Joao Brandao, Simon Jackson
School of Biomedical Sciences
Current methods for testing water for faecal contamination rely on the culture of faecal indicator bacteria (FIB; Escherichia coli and Enterococci) that take 24–48 h, which leads to delays in taking proactive measures and poses a risk to public health. More rapid methods are therefore required. Here, we have tested a rapid, portable assay (Bacterisk) that detects the bacterial biomarker endotoxin in 30 min to quantify the bacterial biomass present, to evaluate 159 coastal water samples and to compare the results with the traditional culture of FIB. There was a significant correlation between the Bacterisk data given in endotoxin risk …
Marine Protected Areas Can Increase The Abundance Of Invasive Lionfish (Pterois Miles), Periklis Kleitou, Sian E. Rees, Demetris Kletou, Holden E. Harris, Leda L. Cai, Stephanie Green, Louis Hadjioannou, Ioannis Savva, Ioannis Giovos, Carlos Jimenez, Jason M. Hall-Spencer
Marine Protected Areas Can Increase The Abundance Of Invasive Lionfish (Pterois Miles), Periklis Kleitou, Sian E. Rees, Demetris Kletou, Holden E. Harris, Leda L. Cai, Stephanie Green, Louis Hadjioannou, Ioannis Savva, Ioannis Giovos, Carlos Jimenez, Jason M. Hall-Spencer
School of Biological and Marine Sciences
Marine protected areas (MPAs) can protect and restore marine biodiversity and fisheries, but there are concerns that they may also benefit invasive species. The spatial and temporal colonization of invasive lionfish (Pterois miles) in the eastern Mediterranean was compared across zones with varying fishing restrictions (no fishing, recreational and commercial fishing, and commercial fishing only), and stations where targeted removal events were conducted by volunteer SCUBA divers. Lionfish density in no fishing areas was nearly double that of areas with commercial fishing only, and over four times greater than in areas where both commercial and recreational fishing were allowed. Lionfish …
Improving Mangoes' Productivity And Crop Water Productivity By 24-Epibrassinosteroids And Hydrogen Peroxide Under Deficit Irrigation, Mahmoud Abdel-Sattar, Rashid S. Al-Obeed, Essa Makhasha, Laila Y. Mostafa, Rania A.E. Abdelzaher, Hail Z. Rihan
Improving Mangoes' Productivity And Crop Water Productivity By 24-Epibrassinosteroids And Hydrogen Peroxide Under Deficit Irrigation, Mahmoud Abdel-Sattar, Rashid S. Al-Obeed, Essa Makhasha, Laila Y. Mostafa, Rania A.E. Abdelzaher, Hail Z. Rihan
School of Biological and Marine Sciences
In nature, plants are frequently subjected to a wide range of abiotic stresses that drastically reduce crop productivity. Deficit in irrigation is one of the main factors of abiotic stresses that affect agricultural productivity. Nevertheless, not much research has been done on how to use water with brassinosteroids (Br) and hydrogen peroxide (H2O2)in deficit water conditions in order to reach comparatively good values of mango tree growth, productivity, and fruit quality as well as crop water productivity (WPC). A split-plot experiment in a complete randomized block system design study with 3 regulated deficit irrigation …
Case-Based Learning In Undergraduate Orthodontic Education: A Cross Sectional Study, Asma Shafique, Asad Rehman, Shazia Ibnerasa, Rebecca Glanville, Professor Kamran Ali
Case-Based Learning In Undergraduate Orthodontic Education: A Cross Sectional Study, Asma Shafique, Asad Rehman, Shazia Ibnerasa, Rebecca Glanville, Professor Kamran Ali
Peninsula Dental School
Introduction Student centric learning approaches have been reported to be effective in introducing higher order cognitive skills required by the health professionals. However, learners’ perceptions must be constructively aligned with new learning interventions to achieve a positive impact on their learning. The aim of this study was to explore the learning experiences of undergraduate dental students with case-based learning in orthodontics. Methods A case-based learning model was introduced on orthodontic diagnosis and treatment planning for final year students on a Bachelor of Dentistry programme toward the end of their academic year. A survey was conducted to explore the perceptions and …
Examining Ecological Harshness, Sociosexuality, And Mate Value In Women’S Preferences For Men’S Height And Shoulder-To-Hip Ratio, Ray Garza, Regina Gonzalez Elizondo, Farid Pazhoohi
Examining Ecological Harshness, Sociosexuality, And Mate Value In Women’S Preferences For Men’S Height And Shoulder-To-Hip Ratio, Ray Garza, Regina Gonzalez Elizondo, Farid Pazhoohi
School of Psychology
Physical features in men, such as height and shoulder-to-hip ratio (SHR), have been shown to contribute to women’s mate preferences. The independent and interactive effects of height and SHR have been shown to be associated with attractiveness, masculinity, dominance, and fighting ability. It is suggested that these sexually dimorphic features are a reflection of men’s genetic quality, in addition to the ability to provide direct benefits (e.g., protection, resource provisioning). The current study investigated how ecological harshness may modulate women’s mate preferences to men displaying variations in height and SHR ratio. In a sample of predominately Hispanic women (N = …
Maternal Mental Health And Breastfeeding Duration: The Role Of Optimism And Coping Strategies., Alison Bacon, Alyson Norman, Eleanor Mason
Maternal Mental Health And Breastfeeding Duration: The Role Of Optimism And Coping Strategies., Alison Bacon, Alyson Norman, Eleanor Mason
School of Psychology
Background/AimsMental health can influence the likelihood that a woman will initiate and continue breastfeeding behaviour that is associated with improved infant and maternal health. Mental health outcomes are associated with variables such as optimism and coping. The aim of this study was to explore the relationship between coping, optimism and mental health, and their impact on breastfeeding duration.MethodsA total of 612 women who had breastfed completed an online questionnaire comprising the hospital anxiety and depression scale, cognitive emotional regulation questionnaire, brief coping orientation to problems experienced inventory and life orientation test. Data were analysed using correlations, ordinal linear regression and …
Measuring Affect-Related Attention Bias To Emotionally Valenced Visual Stimuli In Horses, Sarah Kappel, Marco A.Ramirez Montes De Oca, Sarah Collins, Katherine Herborn, Michael Mendl, Carole Fureix
Measuring Affect-Related Attention Bias To Emotionally Valenced Visual Stimuli In Horses, Sarah Kappel, Marco A.Ramirez Montes De Oca, Sarah Collins, Katherine Herborn, Michael Mendl, Carole Fureix
School of Biological and Marine Sciences
Negative affect appears to mediate animals’ attention to competing emotional stimuli (e.g., threatening vs. non-threatening conspecific face images), similarly to anxiety-related enhanced attention to social threat reported in humans. To investigate this ‘attention bias’ (AB, i.e., the differential attention allocation to certain types of information over others) in horses, we developed a visual AB test assessing horses’ attention towards image pairs showing unfamiliar conspecifics’ facial expressions indicating, a) negative (social threat), b) more neutral (at rest), and c) positive (food anticipation) situations. We predicted that horses exhibit greater attention to negative compared to neutral or positive face images (as a …
Dev-Resnet: Automated Developmental Event Detection Using Deep Learning, Ziad Ibbini, Manuela Truebano, John I. Spicer, Jamie C.S. Mccoy, Oliver Tills
Dev-Resnet: Automated Developmental Event Detection Using Deep Learning, Ziad Ibbini, Manuela Truebano, John I. Spicer, Jamie C.S. Mccoy, Oliver Tills
School of Biological and Marine Sciences
Delineating developmental events is central to experimental research using early life stages, permitting widespread identification of changes in event timing between species and environments. Yet, identifying developmental events is incredibly challenging, limiting the scale, reproducibility and throughput of using early life stages in experimental biology.We introduce Dev-ResNet, a small and efficient 3D convolutional neural network capable of detecting developmental events characterised by both spatial and temporal features, such as the onset of cardiac function and radula activity. We demonstrate the efficacy of Dev-ResNet using 10 diverse functional events throughout the embryonic development of the great pond snail, Lymnaea stagnalis. Dev-ResNet …
Intergenerational Technology Codesign In Deprived Coastal Regions, Ray Jones, Rory Baxter, Marius N. Varga, Oksana Hagen, Amir Aly, Dena Bazazian, Alejandro Veliz Reyes, Swen Gaudl
Intergenerational Technology Codesign In Deprived Coastal Regions, Ray Jones, Rory Baxter, Marius N. Varga, Oksana Hagen, Amir Aly, Dena Bazazian, Alejandro Veliz Reyes, Swen Gaudl
School of Nursing and Midwifery
Many coastal and rural areas in Britain are deprived. This regional aspect multiplies the effect of digital exclusion for older people. Younger people in these regions can also be digitally excluded. Codesigning digital technologies, using the natural and heritage resources of such regions would address this, but is rarely done. We present our methods and preliminary results, half-way through a 30-month project to develop novel technologies in extended reality, underwater telepresence, digital social games, and artificial intelligence voice interfaces and to use these assets to tackle digital exclusion. We are taking an intergenerational approach, working with 35 partner organizations, some …
Genetic Diversity And Relationships Among Indian Jujube (Ziziphus Mauritiana Lamk.) Cultivars Using Morphometric Characteristics, Matk Barcoding, And Issr Markers, Mahmoud Abdel-Sattar, Rashid S. Al-Obeed, Hail Z. Rihan, Ghada E. El-Badan
Genetic Diversity And Relationships Among Indian Jujube (Ziziphus Mauritiana Lamk.) Cultivars Using Morphometric Characteristics, Matk Barcoding, And Issr Markers, Mahmoud Abdel-Sattar, Rashid S. Al-Obeed, Hail Z. Rihan, Ghada E. El-Badan
School of Biological and Marine Sciences
Indian jujube displays genetic diversity and does not prominently display minute morphometric variations, and this makes correct identification a difficult and long-term task. However, little work has been conducted to bring jujube cultivars into domestication. So, the present study aimed to evaluate eleven cultivars of Indian jujube in terms of the fruit’s morphometric characteristics, as well as molecular marker studies by plastidial megakaryocyte-associated tyrosine kinase (matK) barcoding and inter-simple sequence repeats (ISSR) markers for species differentiation, identification, and relationships among Indian jujube cultivars. The results of the morphometric characteristics showed that the mean geometric diameter, surface area, sphericity, sphericity ratio, …
Response To Comments On The Tolerance To Clostridioides Difficile Spores To Sodium Hypochlorite Disinfection, Humaira Ahmed, Lovleen Tina Joshi
Response To Comments On The Tolerance To Clostridioides Difficile Spores To Sodium Hypochlorite Disinfection, Humaira Ahmed, Lovleen Tina Joshi
Peninsula Dental School
No abstract provided.
The Outcomes Measured And Reported In Observational Studies Of Incidental And Untreated Intracranial Meningioma: A Systematic Review, Christopher P. Millward, Abdurrahman I. Islim, Terri S. Armstrong, Heather Barrington, Sabrina Bell, Andrew R. Brodbelt, Helen Bulbeck, Linda Dirven, Paul L. Grundy, Mohsen Javadpour, Sumirat M. Keshwara, Shelli D. Koszdin, Anthony G. Marson, Michael W. Mcdermott, Torstein R. Meling, Kathy Oliver, Puneet Plaha, Matthias Preusser, Thomas Santarius, Nisaharan Srikandarajah, Martin J.B. Taphoorn, Carole Turner, Colin Watts, Michael Weller, Paula R. Williamson, Gelareh Zadeh, Amir H. Zamanipoor Najafabadi, Michael D. Jenkinson, Oliver Hanemann
The Outcomes Measured And Reported In Observational Studies Of Incidental And Untreated Intracranial Meningioma: A Systematic Review, Christopher P. Millward, Abdurrahman I. Islim, Terri S. Armstrong, Heather Barrington, Sabrina Bell, Andrew R. Brodbelt, Helen Bulbeck, Linda Dirven, Paul L. Grundy, Mohsen Javadpour, Sumirat M. Keshwara, Shelli D. Koszdin, Anthony G. Marson, Michael W. Mcdermott, Torstein R. Meling, Kathy Oliver, Puneet Plaha, Matthias Preusser, Thomas Santarius, Nisaharan Srikandarajah, Martin J.B. Taphoorn, Carole Turner, Colin Watts, Michael Weller, Paula R. Williamson, Gelareh Zadeh, Amir H. Zamanipoor Najafabadi, Michael D. Jenkinson, Oliver Hanemann
Peninsula Medical School
Background. The clinical management of patients with incidental intracranial meningioma varies markedly and is often based on clinician choice and observational data. Heterogeneous outcome measurement has likely hampered knowledge progress by preventing comparative analysis of similar cohorts of patients. This systematic review aimed to summarize the outcomes measured and reported in observational studies. Methods. A systematic literature search was performed to identify published full texts describing active monitoring of adult cohorts with incidental and untreated intracranial meningioma (PubMed, EMBASE, MEDLINE, and CINAHL via EBSCO, completed January 24, 2022). Reported outcomes were extracted verbatim, along with an associated definition and method …
Cognitive Rehabilitation Effects On Grey Matter Volume And Go-Nogo Activity In Progressive Multiple Sclerosis: Results From The Cogex Trial, Maria A Rocca, Paola Valsasina, Francesco Romanò, Nicolò Tedone, Maria Pia Amato, Giampaolo Brichetto, Vincenzo Daniele Boccia, Jeremy Chataway, Nancy D Chiaravalloti, Gary Cutter, Ulrik Dalgas, John Deluca, Rachel A Farrell, Peter Feys, Jennifer Freeman, Matilde Inglese, Cecilia Meza, Robert W Motl, Amber Salter, Brian M Sandroff, Anthony Feinstein, Massimo Filippi
Cognitive Rehabilitation Effects On Grey Matter Volume And Go-Nogo Activity In Progressive Multiple Sclerosis: Results From The Cogex Trial, Maria A Rocca, Paola Valsasina, Francesco Romanò, Nicolò Tedone, Maria Pia Amato, Giampaolo Brichetto, Vincenzo Daniele Boccia, Jeremy Chataway, Nancy D Chiaravalloti, Gary Cutter, Ulrik Dalgas, John Deluca, Rachel A Farrell, Peter Feys, Jennifer Freeman, Matilde Inglese, Cecilia Meza, Robert W Motl, Amber Salter, Brian M Sandroff, Anthony Feinstein, Massimo Filippi
School of Health Professions
Background: Research on cognitive rehabilitation (CR) and aerobic exercise (EX) to improve cognition in progressive multiple sclerosis (PMS) remains limited. CogEx trial investigated the effectiveness of CR and EX in PMS: here, we present MRI substudy volumetric and task-related functional MRI (fMRI) findings. Methods: Participants were randomised to: 'CR plus EX', ' CR plus sham EX (EX-S)', ' EX plus sham CR (CR-S)' and ' CR-S plus EX-S"and attended 12-week intervention. All subjects performed physical/cognitive assessments at baseline, week 12 and 6 months post intervention (month 9). All MRI substudy participants underwent volumetric MRI and fMRI (Go-NoGo task). Results: 104 …
Investigating The Effects Of Male Size And Pronotal Glowspots On Female Courtship Behaviour Of The Glowspot Cockroach (Lucihormetica Verrucosa), Ella X. Whitaker, Jane Akerman, Alexander D.M. Wilson
Investigating The Effects Of Male Size And Pronotal Glowspots On Female Courtship Behaviour Of The Glowspot Cockroach (Lucihormetica Verrucosa), Ella X. Whitaker, Jane Akerman, Alexander D.M. Wilson
School of Biological and Marine Sciences
Lucihormetica verrucosa (Blattodea, Blaberidae) are highly sexually dimorphic cockroaches, with the males having two symmetrically organised ‘glowspots’ on their pronotum. The spots can range in colour from whitish-yellow to red, depending on the quantity of carotenoids in their diet. These spots auto-fluoresce when exposed to UV wavelengths, with the amount of fluorescence inversely related to the carotenoid content. The diet-dependent aspect of the pronotal spots insinuates that they are a fitness-dependent trait and thus inform sexual selection, but existing studies have not directly investigated the role of the pronotal spots in courtship behaviour. Invertebrate sexual selection is commonly informed by …
Carbon Stocks And Fluxes From A Boreal Conifer Swamp: Filling A Knowledge Gap For Understanding The Boreal C Cycle, Sj Davidson, Marissa Davies, E Wegener, S Claussen, M Schmidt, M Peacock, M Strack
Carbon Stocks And Fluxes From A Boreal Conifer Swamp: Filling A Knowledge Gap For Understanding The Boreal C Cycle, Sj Davidson, Marissa Davies, E Wegener, S Claussen, M Schmidt, M Peacock, M Strack
School of Geography, Earth and Environmental Sciences
The carbon (C) dynamics of boreal coniferous swamps are a largely understudied component of wetland carbon cycling. We investigated the above- and below-ground carbon stocks and growing season carbon dioxide (CO 2) and methane (CH 4) fluxes from a representative boreal coniferous swamp in northern Alberta, Canada in 2022. Tree inventories, understory vegetation biomass and peat cores were collected across three sub-sites within the broader swamp, with gas flux collars placed in the dominant plant communities present. Alongside the C flux measurements, environmental variables such as water table depth, soil temperature and growing season understory green leaf phenology …
Controls On Distributions Of Aluminium, Manganese And Cobalt In The South Atlantic Ocean Along Geotraces Transect Ga10, Xue Gang Chen, Angela Milne, Jessica K. Klar, Martha Gledhill, Maeve C. Lohan, Yu Te Hsieh, Gideon M. Henderson, E. Malcolm S. Woodward, Eric P. Achterberg
Controls On Distributions Of Aluminium, Manganese And Cobalt In The South Atlantic Ocean Along Geotraces Transect Ga10, Xue Gang Chen, Angela Milne, Jessica K. Klar, Martha Gledhill, Maeve C. Lohan, Yu Te Hsieh, Gideon M. Henderson, E. Malcolm S. Woodward, Eric P. Achterberg
School of Geography, Earth and Environmental Sciences
Trace metals (TMs) manganese (Mn), cobalt (Co), and aluminium (Al) have important geochemical and biological roles in the ocean. Here, we present full depth profiles of dissolved (d) and particulate Al, Mn, and Co along the latitude of 40 °S in the South Atlantic Ocean from the GEOTRACES GA10 cruises that operated in austral spring 2010 and summer 2011. The region is characterized by enhanced primary productivity and forms a key transition zone between the Southern Ocean and South Atlantic Subtropical Gyre. The mean concentrations of dAl, dCo, and dMn (±standard deviation) were 3.36 ± 2.65 nmol kg−1, …
Assessing The Impact Of An Offshore Longline Mussel Farm On Local Water Circulation In A Highly Hydrodynamic Energetic Bay, Llucia Mascorda-Cabre, Emma V. Sheehan, Martin J. Attrill, Phil Hosegood
Assessing The Impact Of An Offshore Longline Mussel Farm On Local Water Circulation In A Highly Hydrodynamic Energetic Bay, Llucia Mascorda-Cabre, Emma V. Sheehan, Martin J. Attrill, Phil Hosegood
School of Biological and Marine Sciences
Thought to be a sustainable choice, molluscs are the most consumed aquaculture foods after finfish. The expansion of the mussel aquaculture industry offshore reports lower environmental impacts compared to inshore farms. Although an offshore location has the potential to reduce a farm's ecological impacts, the effect of large developments on water currents is still not fully understood. High hydrodynamic regimes can influence the dispersion of farm biodeposits, organic loading, flow alterations with the potential to impact water residence time, particle and sediment dispersal (including larvae and biodeposits) and seabed sediment resuspension, which in turn, can have ecological impacts. Farm-induced flow …
Collective Order And Group Structure Of Shoaling Fish Subject To Differing Risk-Level Treatments With A Sympatric Predator, Timothy M. Schaerf, Alexander D.M. Wilson, Mitchell Welch, Ashley J.W. Ward
Collective Order And Group Structure Of Shoaling Fish Subject To Differing Risk-Level Treatments With A Sympatric Predator, Timothy M. Schaerf, Alexander D.M. Wilson, Mitchell Welch, Ashley J.W. Ward
School of Biological and Marine Sciences
It is imperative for individuals to exhibit flexible behaviour according to ecological context, such as available resources or predation threat. Manipulative studies on responses to threat often focus on behaviour in the presence of a single indicator for the potential of predation, whereas in the wild perception of threat will probably be more nuanced. Here, we examine the collective behaviour of eastern mosquitofish (Gambusia holbrooki) subject to five differing threat scenarios relating to the presence and hunger state of a jade perch (Scortum barcoo). Across threat scenarios, groups exhibit unique behavioural profiles that differ in the durations that particular collective …
Immunogenicity And Protective Capacity Of Sugar Abc Transporter Substrate-Binding Protein Against Streptococcus Suis Serotype 2, 7 And 9 Infection In Mice, Zujie Yan, Ruyi Pan, Junjie Zhang, Jianhe Sun, Xiaochun Ma, Nihua Dong, Xiaohui Yao, Jianchao Wei, Ke Liu, Yafeng Qiu, Katie Sealey, Hester Nichols, Michael A. Jarvis, Mathew Upton, Xiangdong Li, Zhiyong Ma, Juxiang Liu, Beibei Li
Immunogenicity And Protective Capacity Of Sugar Abc Transporter Substrate-Binding Protein Against Streptococcus Suis Serotype 2, 7 And 9 Infection In Mice, Zujie Yan, Ruyi Pan, Junjie Zhang, Jianhe Sun, Xiaochun Ma, Nihua Dong, Xiaohui Yao, Jianchao Wei, Ke Liu, Yafeng Qiu, Katie Sealey, Hester Nichols, Michael A. Jarvis, Mathew Upton, Xiangdong Li, Zhiyong Ma, Juxiang Liu, Beibei Li
School of Biomedical Sciences
Background: Streptococcus suis (S. suis) is a Gram-positive bacterium that causes substantial disease in pigs. S. suis is also an emerging zoonoses in humans, primarily in Asia, through the consumption of undercooked pork and the handling of infected pig meat as well as carcasses. The complexity of S. suis epidemiology, characterized by the presence of multiple bacterial serotypes and strains with diverse sequence types, identifies a critical need for a universal vaccine with the ability to confer cross-protective immunity. Highly conserved immunogenic proteins are generally considered good candidate antigens for subunit universal vaccines. Methods: In this study, the cross-protection of …
Herbal Medicines To Prevent Dental Caries, Philip Pradeep, Anchu Rachel Thomas, Kanwardeep Kaur, Renu Sarah Samson, Arun Mayya, Shripathi Adiga, Sumanth Kumbargere Nagraj
Herbal Medicines To Prevent Dental Caries, Philip Pradeep, Anchu Rachel Thomas, Kanwardeep Kaur, Renu Sarah Samson, Arun Mayya, Shripathi Adiga, Sumanth Kumbargere Nagraj
Peninsula Dental School
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the effects of herbs/herbal extracts to prevent or minimise tooth decay in children and adults.
Are Impacts Of The Invasive Alien Plant Crassula Helmsii Mediated By Detritus? A Litter Experiment In A Temperate Pond, Samuel J.L. Tasker, Andrew Foggo, David T. Bilton
Are Impacts Of The Invasive Alien Plant Crassula Helmsii Mediated By Detritus? A Litter Experiment In A Temperate Pond, Samuel J.L. Tasker, Andrew Foggo, David T. Bilton
School of Biological and Marine Sciences
Because of the high growth rates often achieved by invasive alien macrophytes, their establishment in recipient ecosystems may alter the abundance and composition of litter entering detrital pathways, representing a significant—but often overlooked—ecological effect of these invasions. Crassula helmsii (Kirk) Cockayne (New Zealand pygmyweed) is an invasive alien macrophyte, notorious for its profuse growth in invaded waterbodies. C. helmsii is perennial and often forms dense stands, producing abundant detritus. To investigate whether some of C. helmsii’s impacts are mediated by this detritus, we conducted an 85-day litterbag experiment comparing decomposition of C. helmsii with that of Callitriche stagnalis Scop. (water-starwort), …
Coastal Greening Of Grey Infrastructure: An Update On The State-Of-The-Art, Louise B. Firth, Jessica Bone, Aaron Bartholomew, Melanie J. Bishop, Ana Bugnot, Fabio Bulleri, Su Yin Chee, Louw Claassens, Katherine A. Dafforn, Tom P. Fairchild, Alice E. Hall, Mick E. Hanley, Valeriya Komyakova, Anaëlle J. Lemasson, Lynette H.L. Loke, Mariana Mayer-Pinto, Rebecca Morris, Larissa Naylor, Matthew J. Perkins, Sylvain Pioch, Francesca Porri, Kathryn A. O'Shaughnessy, Nina Schaefer, Elisabeth A. Strain, Jason D. Toft, Nathan Waltham, Moises Aguilera, Laura Airoldi, Franz Bauer, Paul Brooks
Coastal Greening Of Grey Infrastructure: An Update On The State-Of-The-Art, Louise B. Firth, Jessica Bone, Aaron Bartholomew, Melanie J. Bishop, Ana Bugnot, Fabio Bulleri, Su Yin Chee, Louw Claassens, Katherine A. Dafforn, Tom P. Fairchild, Alice E. Hall, Mick E. Hanley, Valeriya Komyakova, Anaëlle J. Lemasson, Lynette H.L. Loke, Mariana Mayer-Pinto, Rebecca Morris, Larissa Naylor, Matthew J. Perkins, Sylvain Pioch, Francesca Porri, Kathryn A. O'Shaughnessy, Nina Schaefer, Elisabeth A. Strain, Jason D. Toft, Nathan Waltham, Moises Aguilera, Laura Airoldi, Franz Bauer, Paul Brooks
School of Biological and Marine Sciences
In the marine environment, greening of grey infrastructure (GGI) is a rapidly growing field that attempts to encourage native marine life to colonise marine artificial structures to enhance biodiversity, thereby promoting ecosystem functioning and hence service provision. By designing multifunctional sea defences, breakwaters, port complexes and offshore renewable energy installations, these structures can yield myriad environmental benefits, in particular, addressing UN SDG 14: Life below water. Although GGI has shown great promise and there is a growing evidence base, there remain many criticisms and knowledge gaps, and some feel that there is scope for GGI to be abused by developers …
Prevalence And Associated Clinical Characteristics Of Walking-Related Motor, Cognitive, And Fatigability In Progressive Multiple Sclerosis: Baseline Results From The Cogex Study, Cintia Ramari, Mieke D’Hooge, Ulrik Dalgas, Anthony Feinstein, Maria Pia Amato, Giampaolo Brichetto, Jeremy Chataway, Nancy D. Chiaravalloti, Gary R. Cutter, John Deluca, Rachel Farrell, Massimo Filippi, Jennifer Freeman, Matilde Inglese, Cecilia Meza, Robert W. Motl, Maria A. Rocca, Brian M. Sandroff, Amber Salter, Daphne Kos, Peter Feys
Prevalence And Associated Clinical Characteristics Of Walking-Related Motor, Cognitive, And Fatigability In Progressive Multiple Sclerosis: Baseline Results From The Cogex Study, Cintia Ramari, Mieke D’Hooge, Ulrik Dalgas, Anthony Feinstein, Maria Pia Amato, Giampaolo Brichetto, Jeremy Chataway, Nancy D. Chiaravalloti, Gary R. Cutter, John Deluca, Rachel Farrell, Massimo Filippi, Jennifer Freeman, Matilde Inglese, Cecilia Meza, Robert W. Motl, Maria A. Rocca, Brian M. Sandroff, Amber Salter, Daphne Kos, Peter Feys
School of Health Professions
Background: People with progressive multiple sclerosis (PMS) present motor (eg, walking) and cognitive impairments, and report fatigue. Fatigue encompasses fatigability which is objectively measured by the capacity to sustain a motor or cognitive task. Objective: To investigate the prevalence of walking and cognitive fatigability (CF) and the associated clinical characteristics in a large sample of PMS patients. Methods: PMS patients (25-65 years old) were included from 11 sites (Europe and North America), having cognitive impairment (1.28 standard deviation below normative data for the symbol digit modality test [SDMT]). Walking fatigability (WF) was assessed using the distance walk index (DWI) and …
Biochar Improves Fertility In Waste Derived Manufactured Soils, But Not Resilience To Climate Change, Jennifer M. Rhymes, Daniel Evans, Giuliano Laudone, H. Kate Schofield, Ellen Fry, Mark F. Fitzsimons
Biochar Improves Fertility In Waste Derived Manufactured Soils, But Not Resilience To Climate Change, Jennifer M. Rhymes, Daniel Evans, Giuliano Laudone, H. Kate Schofield, Ellen Fry, Mark F. Fitzsimons
School of Geography, Earth and Environmental Sciences
We present a soil manufactured from waste materials, which could replace the use of peat and topsoil in plant production and reduce the pressure on natural soil resources. We tested the effect of the manufactured soil on ecosystem functions and microbial communities with and without plants present, and with and without biochar addition (Experiment 1). The resilience of the soil in response to drought and flooding, and also the effect of biochar was also tested (Experiment 2). Biochar increased soil C and N regardless of plant presence and negated the effect of the plant on soil peroxidase enzyme activity. The …
Effect Of The Age Of Garments Used Under Real-Life Conditions On Microfibre Release From Polyester And Cotton Clothing, Andreia N. Fernandes, Larissa Z. Lara, Francesca De Falco, Andrew Turner, Richard C. Thompson
Effect Of The Age Of Garments Used Under Real-Life Conditions On Microfibre Release From Polyester And Cotton Clothing, Andreia N. Fernandes, Larissa Z. Lara, Francesca De Falco, Andrew Turner, Richard C. Thompson
School of Geography, Earth and Environmental Sciences
The release of microfibres from fabrics during laundering represents an important source of plastic and natural microfibres to aquatic environments. Garment age - how long the garment has been used - could be a key factor influencing the rate of release, yet most studies of microfibre shedding have only assessed newly manufactured products. To this end, we quantified microfibre release during laundering in domestic washing machines from polyester (PES) and cotton garments (n = 38) used in real-life conditions for periods between 1 and 31 years with different use intensities. In addition, to better understand the factors involved in microfibre …
Topography-Based Modulation Of Environmental Factors As A Mechanism For Intertidal Microhabitat Formation: A Basis For Marine Ecological Design, Franz Bauer, Antony M. Knights, Mick E. Hanley, John N. Griffin, Andy Foggo, Austin Brown, Louise B. Firth
Topography-Based Modulation Of Environmental Factors As A Mechanism For Intertidal Microhabitat Formation: A Basis For Marine Ecological Design, Franz Bauer, Antony M. Knights, Mick E. Hanley, John N. Griffin, Andy Foggo, Austin Brown, Louise B. Firth
School of Biological and Marine Sciences
Topographic complexity is often considered to be closely associated with habitat complexity and niche diversity; however, complex topography per se does not imply habitat suitability. Rather, ecologically suitable habitats may emerge if topographic features interact with environmental factors and thereby alter their surrounding microenvironment to the benefit of local organisms (e.g., resource provisioning, stress mitigation). Topography may thus act as a key modulator of abiotic stressors and biotic pressures, particularly in environmentally challenging intertidal systems. Here, we review how topography can alter microhabitat conditions with respect to four resources required by intertidal organisms: a source of energy (light, suspended food …
The Relationship Between Clinical Presentation And The Nature Of Care In Adults With Intellectual Disability And Epilepsy – National Comparative Cohort Study, S Badger, Lv Watkins, P Bassett, A Roy, Et Al
The Relationship Between Clinical Presentation And The Nature Of Care In Adults With Intellectual Disability And Epilepsy – National Comparative Cohort Study, S Badger, Lv Watkins, P Bassett, A Roy, Et Al
Peninsula Medical School
Background A quarter of People with Intellectual Disabilities (PwID) have epilepsy compared with 1% of the general population. Epilepsy in PwID is a bellwether for premature mortality, multimorbidity and polypharmacy. This group depends on their care provider to give relevant information for management, especially epilepsy. There is no research on care status relationship and clinical characteristics of PwID and epilepsy. Aim Explore and compare the clinical characteristics of PwID with epilepsy across different care settings. Method A retrospective multicentre cohort study across England and Wales collected information on seizure characteristics, intellectual disability severity, neurodevelopmental/biological/psychiatric comorbidities, medication including psychotropics/anti-seizure medication, and …
Lysophosphatidylcholine Acetyltransferase 2 (Lpcat2) Influences The Gene Expression Of The Lipopolysaccharide Receptor Complex In Infected Raw264.7 Macrophages, Depending On The E. Coli Lipopolysaccharide Serotype, Victory Ibigo Poloamina, Hanaa Alrammah, Wondwossen Abate, Neil D. Avent, Gyorgy Fejer, Simon K. Jackson
Lysophosphatidylcholine Acetyltransferase 2 (Lpcat2) Influences The Gene Expression Of The Lipopolysaccharide Receptor Complex In Infected Raw264.7 Macrophages, Depending On The E. Coli Lipopolysaccharide Serotype, Victory Ibigo Poloamina, Hanaa Alrammah, Wondwossen Abate, Neil D. Avent, Gyorgy Fejer, Simon K. Jackson
School of Biomedical Sciences
Escherichia coli (E. coli) is a frequent gram-negative bacterium that causes nosocomial infections, affecting more than 100 million patients annually worldwide. Bacterial lipopolysaccharide (LPS) from E. coli binds to toll-like receptor 4 (TLR4) and its co-receptor's cluster of differentiation protein 14 (CD14) and myeloid differentiation factor 2 (MD2), collectively known as the LPS receptor complex. LPCAT2 participates in lipid-raft assembly by phospholipid remodelling. Previous research has proven that LPCAT2 co-localises in lipid rafts with TLR4 and regulates macrophage inflammatory response. However, no published evidence exists of the influence of LPCAT2 on the gene expression of the LPS receptor complex induced …