Digital Commons Network^™

Unraveling The Clcc1 Interactome: Impact Of The Asp25glu Variant And Its Interaction With Sigmar1 At The Mitochondrial-Associated Er Membrane (Mam), Ilaria D'Atri, Emily Rose Martin, Liming Yang, Elizabeth Sears, Emma Baple, Andrew H. Crosby, John K. Chilton, Asami Oguro-Ando

Peninsula Medical School

The endoplasmic reticulum (ER) plays an indispensable role in cellular processes, including maintenance of calcium homeostasis, and protein folding, synthesized and processing. Disruptions in these processes leading to ER stress and the accumulation of misfolded proteins can instigate the unfolded protein response (UPR), culminating in either restoration of balanced proteostasis or apoptosis. A key player in this intricate balance is CLCC1, an ER-resident chloride channel, whose essential role extends to retinal development, regulation of ER stress, and UPR. The importance of CLCC1 is further underscored by its interaction with proteins localized to mitochondria-associated endoplasmic reticulum membranes (MAMs), where it participates …

Physiological And Morphological Plasticity In Response To Nitrogen Availability Of A Yeast Widely Distributed In The Open Ocean, Poppy Diver, Ben A. Ward, Michael Cunliffe

School of Biological and Marine Sciences

Yeasts are prevalent in the open ocean, yet we have limited understanding of their ecophysiological adaptations, including their response to nitrogen availability, which can have a major role in determining the ecological potential of other planktonic microbes. In this study, we characterized the nitrogen uptake capabilities and growth responses of marine-occurring yeasts. Yeast isolates from the North Atlantic Ocean were screened for growth on diverse nitrogen substrates, and across a concentration gradient of three environmentally relevant nitrogen substrates: nitrate, ammonium, and urea. Three strains grew with enriched nitrate while two did not, demonstrating that nitrate utilization is present but not …

Plastic Alternatives And Substitutes In The Packaging Sector – A Uk Consumer Perspective, Sohvi Nuojua, Sabine Pahl, Richard C. Thompson

School of Biological and Marine Sciences

Alternative and substitute materials to conventional plastic packaging offer a range of potential opportunities to help reduce the environmental impacts of single-use plastic. Policymakers and industry stakeholders are currently debating measures to address the plastic pollution crisis globally, but successful implementation of new policies or packaging technologies will require understanding of consumer perspectives and consumer acceptability. The present study aimed to examine consumer perceptions around plastic alternatives and substitutes by employing a life cycle approach. The Kano model of consumer satisfaction was used to investigate how UK consumers (n = 1177) responded to a variety of environmentally relevant attributes and …

Biomonitoring Of Microplastics, Anthropogenic Microfibres And Glass Retroreflective Beads By Marine Macroalgae, Cerys Rimmer, Jodie Fisher, Andrew Turner

School of Geography, Earth and Environmental Sciences

Microplastics and other microscopic debris are a concern in the coastal environment but measurements in the water column and sediment are often problematic and rely on non-standardised and highly variable methodologies. To this end, we explore the potential of different species of temperate-cold marine macroalgae as passive biomonitors of anthropogenic microparticles at three contrasting locations in southwest England. Specifically, fronds from samples of fucoids and Ulva lactuca (n = 9 in total, and three from each location) have been sectioned and analysed directly under a microscope and anthropogenic microparticles counted and subsequently characterised for chemical composition. Microparticles were heterogeneously distributed …

The Relationship Between Clinical Presentation And The Nature Of Care In Adults With Intellectual Disability And Epilepsy - National Comparative Cohort Study, Sarah Badger, Lance V. Watkins, Paul Bassett, Ashok Roy, Mogbeyiteren Eyeoyibo, Indermeet Sawhney, Kiran Purandare, Laurie Wood, Andrea Pugh, Joanne Hammett, Rory Sheehan, Samuel Tromans, Rohit Shankar

Peninsula Medical School

BACKGROUND: A quarter of People with Intellectual Disabilities (PwID) have epilepsy compared with 1% of the general population. Epilepsy in PwID is a bellwether for premature mortality, multimorbidity and polypharmacy. This group depends on their care provider to give relevant information for management, especially epilepsy. There is no research on care status relationship and clinical characteristics of PwID and epilepsy.

AIM: Explore and compare the clinical characteristics of PwID with epilepsy across different care settings.

METHOD: A retrospective multicentre cohort study across England and Wales collected information on seizure characteristics, intellectual disability severity, neurodevelopmental/biological/psychiatric comorbidities, medication including psychotropics/anti-seizure medication, and …

Extracurricular Enterprise And Entrepreneurship Activities In Higher Education: Understanding Entrepreneurial Competencies And Capabilities, Sarah Preedy, Emily Beaumont

Plymouth Business School

This chapter examines the role extracurricular activities have in developing higher education (HE) student’s entrepreneurial competencies and capabilities. Specifically, this chapter examines: What type of students participate in extracurricular activities? Why do students choose to participate? and What activities offer for entrepreneurial competency and capability development. An electronic survey (e-survey) collected pre-and post-data from two groups: Group A – students participating in extracurricular enterprise and entrepreneurship (EEEx) activities (n = 119); and Group B – students engaged in non-enterprise-related extracurricular activities (n = 72). Findings indicated that students in both groups were motivated to engage in extracurricular activities to enhance …

Planting Of Stimulated Corn Seeds At Different Dates In Spring Seasons, M. M. Khudhair, J. H. Hamza, H. Z. Rihan

School of Biological and Marine Sciences

This study was aimed to investigate the appropriate planting date and tolerance to adverse growing conditions in the spring season through seeds stimulation technology. A field experiment was carried out in the spring seasons of 2022 and 2023 according to a randomized complete block design in a split-plot arrangement with four replications. The main factor is planting dates (February 15^th, March 1^st and 15^th, and April 1^st and 15^th). The secondary factor is seeds stimulation (potassium nitrate 6 mg L ^-1 + licorice extract 6 g L ^-1, as well as …

An Efficient Wheel-Integrated Wireless Power Transfer System Based On High-Permittivity Metasurface, Yu Yao, Maziar Nekovee

School of Engineering, Computing and Mathematics

Efficient wireless power transfer (WPT) systems seamlessly integrated with electric vehicles (EVs) are crucial to their successful massive rollout. This paper proposes a WPT system with a high-permittivity metasurface integrated with a wheel for efficiency enhancement. The single-turn coils with coupling-enhanced rings are explored as transmitter (Tx) and receiver (Rx). The metasurface is composed of high-permittivity elements placed on both surfaces. The symmetric system model ensures bidirectional transmission between EVs and power grids. With the aid of the metasurface, the efficiency of the WPT system is substantially enhanced and maintained within 400 mm.

The Application Of Antimicrobial Stewardship Knowledge To Nursing Practice: A National Survey Of United Kingdom Pre‐Registration Nursing Students, Molly Courtenay, Clare Hawker, Rose Gallagher, Enrique Castro‐Sanchez, Dinah J. Gould, Faten Al Salti, Jennifer Bate, Daniel Cooper, Rebecca Cooper, Rebecca Craig, Rebecca Dickinson, Debbie Fallon, Sharon Mcleod, Kate Morrow, Valerie Ness, Andrew Nichols, Sarah O'Reilly, Sarah Partington, J. Claire Sevenoaks, Matthew Sunter, Jane Turner, Liz W. Underhill, Sarah L. Weaver

School of Nursing and Midwifery

AimTo assess student nurses understanding and skills in the application of antimicrobial stewardship knowledge to practice.DesignQuantitative.MethodsCross-sectional survey.ResultsFive hundred and twenty three student nurses responded across 23 UK universities. Although students felt prepared in competencies in infection prevention and control, patient-centred care and interprofessional collaborative practice, they felt less prepared in competencies in which microbiological knowledge, prescribing and its effect on antimicrobial stewardship is required. Problem-based learning, activities in the clinical setting and face-to-face teaching were identified as the preferred modes of education delivery. Those who had shared antimicrobial stewardship teaching with students from other professions reported the benefits to include …

Scaling Local Climate Action: Learning From Community Organizations To Build A Post-Development Agenda For Central America, Michael Bakal, Nathan Einbinder

School of Biological and Marine Sciences

This article considers the possibilities and limits of reimagining international development policy by taking the values, practices, and worldviews of Indigenous communities as its starting point. Drawing on ethnographic research in Guatemala, we contrast the development industry’s overwhelming focus on economic growth as the gold standard of well-being with the perspective of Maya-Achí groups, who insist that growth and modernization must not come at the expense of the ecology, food sovereignty, or Indigenous ways of life connected to the land. We argue that the Maya-Achi organizations with whom we collaborate offer a philosophy and practice better attuned to the urgency …

Combining Acoustic Telemetry With Archival Tagging To Investigate The Spatial Dynamic Of The Understudied Pollack, Pollachius Pollachius, Marine Gonse, Martial Laurans, Justus Magin, Tina Odaka, Jean Marc Delouis, Stéphane Martin, François Garren, Coline Lazard, Mickael Drogou, Thomas Stamp, Peter Davies, Alice Hall, Emma Sheehan, Mathieu Woillez

School of Biological and Marine Sciences

Combining fish tracking methods is a promising way of leveraging the strengths of each approach while mitigating their individual weaknesses. Acoustic telemetry provides presence information as the fish move within receiver range, eliminating the need for tag recovery. Archival tags, on the other hand, record environmental variables on tag retrieval, enabling continuous path reconstruction of a fish beyond coastal regions. This study capitalizes on the combination of both methods for geolocating pollack, Pollachius pollachius, an understudied species of the northeast Atlantic, where declining stocks are raising concern. Essential knowledge of population structure and connectivity between essential habitats is critically lacking …

Snapshot Study Of Canine Distemper Virus In Bangladesh With On-Site Pcr Detection And Nanopore Sequencing, Zsófia Lanszki, Shafeul Islam, Jalal Uddin Sarder, Shahneaz Ali Khan, Sharmin Chowdhury, Nurul Islam, Zsófia Tauber, Gábor Tóth, Ferenc Jakab, Gábor Kemenesi, Sazeda Akter, Foisal Shikder

School of Biomedical Sciences

Canine distemper virus (CDV) is a highly contagious virus that affects domestic and wild animals, causing severe illness with high mortality rates. Rapid monitoring and sequencing can provide valuable information about circulating CDV strains, which may foster effective vaccination strategies and the successful integration of these into conservation programs. During two site visits in Bangladesh in 2023, we tested a mobile, deployable genomic surveillance setup to explore the genetic diversity and phylogenetic patterns of locally circulating CDV strains. We collected and analysed 355 oral swab samples from stray dogs in Rajshahi and Chattogram cities, Bangladesh. CDV-specific real-time RT-PCR was performed …

Anthropogenic Noise Limits Resource Distribution Without Changing Social Hierarchies, S. Tidau, Mark Briffa

School of Biological and Marine Sciences

Increasing evidence demonstrates that anthropogenic noise is a global pollutant that threatens marine ecosystems. Mounting numbers of studies show its diverse effects on individuals and their behaviour. However, little is known about how individual changes in response to anthropogenic noise could cascade through groups and populations affecting resource distribution vital for survival and fitness. Here we test the hypotheses that anthropogenic noise could alter resource distribution, associated hierarchies and consequently individual benefits. We used groups of hermit crabs, a globally distributed model system for assessing impacts of environmental change on wildlife and measured in controlled laboratory conditions the resource distribution …

Novel Use Of Portable Gamma Sensors To Rapidly Assess Soil Status And Recovery In Degraded East African Agro-Pastoral Land, Will Blake, Aloyce Amasi, Claire Kelly, Shaun Lewin, Francis Mkilema, Furaha Msale, Kelvin Mtei, Linus Munishi, Mona Nasseri, Patrick Ndakidemi, Alex Taylor

School of Geography, Earth and Environmental Sciences

No abstract provided.

Impacts Of Fire And Prospects For Recovery In A Tropical Peat Forest Ecosystem, Me Harrison, Nj Deere, Ma Imron, D Nasir, Adul, Ha Asti, Ja Soler, Nc Boyd, Sm Cheyne, Sa Collins, Lj D'Arcy, Wm Erb, H Green, W Healy, Hendri, B Holly, Pr Houlihan, Sj Husson, Iwan, Ka Jeffers, Ip Kulu, K Kusin, Nc Marchant, Hc Morrogh-Bernard, Se Page, A Purwanto, Br Capilla, Ord Ortega, Santiano, Kl Spencer

School of Biological and Marine Sciences

Uncontrolled fires place considerable burdens on forest ecosystems, compromising our ability to meet conservation and restoration goals. A poor understanding of the impacts of fire on ecosystems and their biodiversity exacerbates this challenge, particularly in tropical regions where few studies have applied consistent analytical techniques to examine a broad range of ecological impacts over multiyear time frames. We compiled 16 y of data on ecosystem properties (17 variables) and biodiversity (21 variables) from a tropical peatland in Indonesia to assess fire impacts and infer the potential for recovery. Burned forest experienced altered structural and microclimatic conditions, resulting in a proliferation …

Adult Brain Tumour Research In 2024: Status, Challenges And Recommendations, Karin Purshouse, Helen J. Bulbeck, Alasdair G. Rooney, Karen E. Noble, Ross D. Carruthers, Gerard Thompson, Petra Hamerlik, Christina Yap, Kathreena M. Kurian, Sarah J. Jefferies, Juanita S. Lopez, Michael D. Jenkinson, C. Oliver Hanemann, Lucy F. Stead

Peninsula Medical School

In 2015, a groundswell of brain tumour patient, carer and charity activism compelled the UK Minister for Life Sciences to form a brain tumour research task and finish group. This resulted, in 2018, with the UK government pledging £20m of funding, to be paralleled with £25m from Cancer Research UK, specifically for neuro-oncology research over the subsequent 5 years. Herein, we review if and how the adult brain tumour research landscape in the United Kingdom has changed over that time and what challenges and bottlenecks remain. We have identified seven universal brain tumour research priorities and three cross-cutting themes, which …

Bacterial And Viral Co-Infections In Aquaculture Under Climate Warming: Co-Evolutionary Implications, Diagnosis, And Treatment, S Vega-Heredia, I Giffard-Mena, M Reverter

School of Biological and Marine Sciences

Climate change and the associated environmental temperature fluctuations are contributing to increases in the frequency and severity of disease outbreaks in both wild and farmed aquatic species. This has a significant impact on biodiversity and also puts global food production systems, such as aquaculture, at risk. Most infections are the result of complex interactions be - tween multiple pathogens, and understanding these interactions and their co-evolutionary mechanisms is crucial for developing effective diagnosis and control strategies. In this review, we discuss current knowledge on bacteria-bacteria, virus-virus, and bacterial and viral co-infections in aquaculture as well as their co-evolution in the …

Structure And Replication Cycle Of A Virus Infecting Climate-Modulating Alga Emiliania Huxleyi, Miroslav Homola, Carina R. Büttner, Tibor Füzik, Pavel Křepelka, Radka Holbová, Jiří Nováček, Marten L. Chaillet, Jakub Žák, Danyil Grybchuk, Friedrich Förster, William H. Wilson, Declan C. Schroeder, Pavel Plevka

School of Biological and Marine Sciences

The globally distributed marine alga Emiliania huxleyi has cooling effect on the Earth’s climate. The population density of E. huxleyi is restricted by Nucleocytoviricota viruses, including E. huxleyi virus 201 (EhV-201). Despite the impact of E. huxleyi viruses on the climate, there is limited information about their structure and replication. Here, we show that the dsDNA genome inside the EhV-201 virion is protected by an inner membrane, capsid, and outer membrane. EhV-201 virions infect E. huxleyi by using fivefold vertices to bind to and fuse the virus’ inner membrane with the cell plasma membrane. Progeny virions assemble in the cytoplasm …

In Memoriam: Prof Yuri Alexandrovich Trotsenko (1941-2021), Rich Boden

School of Biological and Marine Sciences

No abstract provided.

The Aggregation Effect Of Offshore Mussel Farming On Pelagic Fishes, D Bridger, Mj Attrill, Se Rees, Ev Sheehan

School of Biological and Marine Sciences

The increase in hard artificial structures in the marine environment is contributing to ocean sprawl. As well as adding hard structure to the seabed, mussel aquaculture adds rope droppers and anchor lines to the water column, where such structure would otherwise be absent. This paper aims to monitor the effects of mussel headlines on the pelagic fish community over time, as well as to investigate whether there is an interaction between the age of cultivated mussels with the number of epibiota species and the abundance of pelagic fishes. Two surveys were carried out: a time series monitoring survey to assess …

Timing Along The Cardiac Cycle Modulates Neural Signals Of Reward-Based Learning, Elsa F. Fouragnan, Billy Hosking, Yin Cheung, Brooke Prakash, Matthew Rushworth, Alejandra Sel

School of Psychology

Natural fluctuations in cardiac activity modulate brain activity associated with sensory stimuli, as well as perceptual decisions about low magnitude, near-threshold stimuli. However, little is known about the relationship between fluctuations in heart activity and other internal representations. Here we investigate whether the cardiac cycle relates to learning-related internal representations – absolute and signed prediction errors. We combined machine learning techniques with electroencephalography with both simple, direct indices of task performance and computational model-derived indices of learning. Our results demonstrate that just as people are more sensitive to low magnitude, near-threshold sensory stimuli in certain cardiac phases, so are they …

Genetic Identification Of Three Cites-Listed Sharks Using A Paper-Based Lab-On-A-Chip (Loc), Guuske P. Tiktak, Alexandria Gabb, Margarita Brandt, Fernando R. Diz, Karla Bravo-Vasquez, Cesar Peñaherrera-Palma, Jonathan Valdiviezo-Rivera, Aaron Carlisle, Louise M. Melling, Bradley Cain, David Megson, Richard Preziosi, Kirsty J. Shaw

School of Biological and Marine Sciences

Threatened shark species are caught in large numbers by artisanal and commercial fisheries and traded globally. Monitoring both which shark species are caught and sold in fisheries, and the export of CITES-restricted products, are essential in reducing illegal fishing. Current methods for species identification rely on visual examination by experts or DNA barcoding techniques requiring specialist laboratory facilities and trained personnel. The need for specialist equipment and/or input from experts means many markets are currently not monitored. We have developed a paper-based Lab-on-A-Chip (LOC) to facilitate identification of three threatened and CITES-listed sharks, bigeye thresher (Alopias superciliosus), pelagic thresher (A. …

Copper Toxicity And Calcium Supplementation On Nkx2.5 And Mt2 Gene Expression In Zebrafish Embryos, Sahib Mohammad Bakir, Theodore B. Henry, Richard D. Handy

School of Biological and Marine Sciences

Background: Heavy metals are pervasive pollutants in aquatic ecosystems, posing significant threats to the survival and development of aquatic organisms, particularly during their early life stages. While copper is necessary for fish growth and maturation, elevated levels of dissolved copper in water can lead to adverse effects on early developmental stages. The aim of this study was to evaluate the expression pattern of the nkx2.5 gene and the potential of Mt2 expression as a biomarker for metal toxicity. Methods: The study assessed the expression levels of the nkx2.5 gene at different time points during embryonic development, focusing particularly on its …

Can We Go Wrong With Getting Strong?, Myles Whitbread-Jordan

South West Clinical School Journal

#400WORDS: KNOWLEDGE + ACTION

Surface Ocean Biogeochemistry And Deep Ocean Circulation Control Relationships Between Nutrient-Type Trace Metals (Cd, Ni, Cu, And Zn) And Nutrients In The South Atlantic Ocean Near The Subtropical Front, Xue Gang Chen, Martha Gledhill, Maeve C. Lohan, Angela Milne, Eric P. Achterberg

School of Geography, Earth and Environmental Sciences

The ocean region along the latitude of 40°S in the South Atlantic, characterized by enhanced primary productivity, forms a transition zone between the nutrient replete but iron depleted Southern Ocean, and the nitrate and iron depleted Subtropical Gyre. Here, we present distributions of nutrient-type dissolved and particulate trace metals (dTMs and pTMs) including cadmium (Cd), nickel (Ni), copper (Cu), and zinc (Zn) in the South Atlantic from the GEOTRACES GA10 cruises. Phytoplankton uptake, riverine and atmospheric inputs shaped dTM and pTM concentrations in surface waters (dCd 27.8 ± 36.0 pmol kg⁻¹, n = 222; dCu 0.732 ± 0.429 …

‘In This Prison We Have Our Main Meal At 11:30 Am’. The Significance Of ‘Time’ For Food Among People Serving Custodial Sentences In England And Wales, Julie M. Parsons

School of Law, Humanities and Social Sciences

In this article, I am thinking through the social life of time for food in prison from a practice theory perspective. I draw upon empirical data from in-depth qualitative interviews with people serving custodial sentences or recently released from prison in England and Wales who have been on placement at a prisoner resettlement charity (RC). These support findings from Her Majesty’s Inspectorate for Prisons report on Life Inside: Food from 2016, and I consider two aspects from the report, (i) an exploration of the standards and conditions in which food is consumed and (ii) the timings of mealtimes. For people …

Blending Behavioural Theory And Narrative Analysis To Explore The Lived Experience Of Obesity And Assess Potential Engagement In A Uk Weight Management Service: Theory And Narrative Approaches In Weight Management, Jessica Gillespie, Hannah Wright, Jonathan Pinkney, Helen Lloyd

School of Psychology

Background: Current treatments for people with obesity emphasise the need for person-centred approaches that consider complex biopsychosocial factors and value the lived experience of people when attempting to lose weight. Methods: Narrative interviews (n = 20) were conducted with people living with obesity to explore the causes of their weight gain and their expectations and engagement with treatment at a Weight Management Clinic. A mixed inductive and deductive qualitative analysis identified utterances that represented psychological constructs used to understand self-appraisal and health behaviour. A narrative analysis was used to situate these findings in the context of a participant’s life story. …

Discovery Of Sqstm1/P62-Dependent P-Bodies That Regulate The Nlrp3 Inflammasome, Elizabeth R. Barrow, Evelina Valionyte, Chris R. Baxter, Yi Yang, Sharon Herath, William A. O'Connell, Justyna Lopatecka, Alexander Strachan, Waldemar Woznica, Holly N. Stephenson, Gyorgy Fejer, Vikram Sharma, Boxun Lu, Shouqing Luo

School of Biomedical Sciences

Autophagy and ribonucleoprotein granules, such as P-bodies (PBs) and stress granules, represent vital stress responses to maintain cellular homeostasis. SQSTM1/p62 phase-separated droplets are known to play critical roles in selective autophagy; however, it is unknown whether p62 can exist as another form in addition to its autophagic droplets. Here, we found that, under stress conditions, including proteotoxicity, endotoxicity, and oxidation, autophagic p62 droplets are transformed to a type of enlarged PBs, termed p62-dependent P-bodies (pd-PBs). p62 phase separation is essential for the nucleation of pd-PBs. Mechanistically, pd-PBs are triggered by enhanced p62 droplet formation upon stress stimulation through the interactions …

Perceptions Of Stakeholders On The Threats And Impacts To The Seascape Of Mauritius, Sarah Heaton, John Martin, Karen Woomed

Professional Services

The seascapes of Small Island Developing States are at risk from anthropogenic pollution. To implement effective seascape management, there is a need to better understand the threats to the seascape, subsequent impacts and associated stakeholder perceptions. This study used a systematic literature review, online survey and follow-up interviews to identify the main threats and impacts to the seascape and analyze associated perceptions of stakeholders, using Mauritius as a case study. The key threats were found to be oil spills, anthropogenic marine debris, coastal development, tourism, poor environmental management, and inadequate enforcement of legislation. Associated perception data showed a high awareness …

Hazardous Explosive Eruptions Of A Recharging Multi-Cyclic Island Arc Caldera, Jonas Preine, Jens Karstens, Christian Hübscher, Tim Druitt, Steffen Kutterolf, Paraskevi Nomikou, Michael Manga, Ralf Gertisser, Katharina Pank, Sarah Beethe, Carole Berthod, Gareth Crutchley, Iona Mcintosh, Thomas Ronge, Masako Tominaga, Acacia Clark, Susan Debari, Raymond Johnston, Zenon Mateo, Ally Peccia, Christopher Jones, Günther Kletetschka, Abigail Metcalfe, Alexis Bernard, Hehe Chen, Shun Chiyonobu, Tatiana Fernandez-Perez, Kumar Batuk Joshi, Olga Koukousioura, Molly Mccanta, Antony Morris, Paraskevi Polymenakou, Adam Woodhouse, Yuzuru Yamamoto, Kuo Lung Wang, Hao Yang Lee, Xiaohui Li, Dimitrios Papanikolaou

School of Geography, Earth and Environmental Sciences

Caldera-forming eruptions of silicic volcanic systems are among the most devastating events on Earth. By contrast, post-collapse volcanic activity initiating new caldera cycles is generally considered less hazardous. Formed after Santorini’s latest caldera-forming eruption of ~1600 bce, the Kameni Volcano in the southern Aegean Sea enables the eruptive evolution of a recharging multi-cyclic caldera to be reconstructed. Kameni’s eruptive record has been documented by onshore products and historical descriptions of mainly effusive eruptions dating back to 197 bce. Here we combine high-resolution seismic reflection data with cored lithologies from International Ocean Discovery Program Expedition 398 at four sites to determine …