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Articles 781 - 810 of 6792
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Sustainability Considerations For End-Of-Life Fibre-Reinforced Plastic Boats, John Summerscales
Sustainability Considerations For End-Of-Life Fibre-Reinforced Plastic Boats, John Summerscales
School of Engineering, Computing and Mathematics
No abstract provided.
Conservation And Management Of Chondrichthyans In The Mediterranean Sea: Gaps, Overlaps, Inconsistencies, And The Way Forward, Jason Lowther, Lydia Koehler, Ioannis Giovos, Jennifer M. Pytka, Monica Barone, Camille Loth, Dimitirios K. Moutoploulos, Simone Niedermuller, Carlotta Mazzoldi
Conservation And Management Of Chondrichthyans In The Mediterranean Sea: Gaps, Overlaps, Inconsistencies, And The Way Forward, Jason Lowther, Lydia Koehler, Ioannis Giovos, Jennifer M. Pytka, Monica Barone, Camille Loth, Dimitirios K. Moutoploulos, Simone Niedermuller, Carlotta Mazzoldi
School of Law, Humanities and Social Sciences
Over one third of sharks, rays and chimaeras (chondrichthyans) are threatened with extinction globally. In the Mediterranean Sea, more than half of chondrichthyan species face this risk, although a variety of international, regional, and national rules and regulations apply directly and indirectly targeting management and conservation for these species. In this work, we provide an overview of relevant legislation and policies in the region, which regulate, inter alia, commercial fisheries, while highlighting through cases studies how implementation in practice at national level looks like. Horizontal gaps and inconsistencies that hinder chondrichthyan management in the region are also illustrated. Furthermore, we …
Barriers And Facilitators To Healthy Eating In Disadvantaged Adults Living In The Uk:: A Scoping Review, R Briazu, F Masood, Louise Hunt, Clare Pettinger, Carol Wagstaff, R Mccloy
Barriers And Facilitators To Healthy Eating In Disadvantaged Adults Living In The Uk:: A Scoping Review, R Briazu, F Masood, Louise Hunt, Clare Pettinger, Carol Wagstaff, R Mccloy
School of Health Professions
In the UK people living in disadvantaged communities are less likely than those with higher socio-economic status to have a healthy diet. To address this inequality, it is crucial scientists, practitioners and policy makers understand the factors that hinder and assist healthy food choice in these individuals. In this scoping review, we aimed to identify barriers and facilitators to healthy eating among disadvantaged individuals living in the UK. Additionally, we used the Theoretical Domains Framework (TDF) to synthesise results and provide a guide for the development of theory-informed behaviour change interventions. Five databases were searched, (CINAHL, Embase, MEDLINE, PsycINFO, and …
Croning Academics: Menopause Matters In Higher Education, Marie Lavelle, Joanna Haynes, Emma Macleod-Johnstone
Croning Academics: Menopause Matters In Higher Education, Marie Lavelle, Joanna Haynes, Emma Macleod-Johnstone
School of Law, Humanities and Social Sciences
This writing is born out of our experiences of becoming older women, academy hags, facing the performative demands of the neoliberalising patriarchal university. We are raging. With the figure of the Crone, and feminist-killjoy-croning as our creative and livid research method (Ahmed, 2023), we squeeze time out/with impossible university spaces and schedules to tend to grey matters. The paper traces the normalisation of menopause policies in workplaces and universities, following the social trending and capitalisation of menopausal and ageing matters. We question what menopause policies do and argue they constitute a failed project for the advancement of gender equality and …
Chemical Analysis Of Flotsam Ambergris, Steven J. Rowland, Paul A. Sutton, C. Anthony Lewis, Timothy Knowles, Michael J. Wilde, Filipe Alves, Robert Clough
Chemical Analysis Of Flotsam Ambergris, Steven J. Rowland, Paul A. Sutton, C. Anthony Lewis, Timothy Knowles, Michael J. Wilde, Filipe Alves, Robert Clough
School of Geography, Earth and Environmental Sciences
The natural product ambergris is only found rarely on beaches, as jetsam. Even more scarce, or even absent, are accounts of flotsam ambergris. Here, we report the chemical analysis of a rare, large piece (>100kg) of flotsam found in the Atlantic in 2019. About 95% of subsamples from the outside of the coprolith was soluble in dichloromethane. Of this, FTIR spectroscopy, APCI-MS and GC-MS indicated the presence of ambrein. Radiocarbon dating indicated that the sample was post 1950s in age. The 13C/12C isotope ratio (−22.5 ‰) was typical of those reported to date for whale ‘body’ …
Targeting Histone Deacetylase 6 (Hdac6) To Enhance Radiation Therapy In Meningiomas In A 2d And 3d In Vitro Study, Juri Na, Shahana Shaji, C. Oliver Hanemann
Targeting Histone Deacetylase 6 (Hdac6) To Enhance Radiation Therapy In Meningiomas In A 2d And 3d In Vitro Study, Juri Na, Shahana Shaji, C. Oliver Hanemann
Peninsula Medical School
Background: External radiation therapy (RT) is often a primary treatment for inoperable meningiomas in the absence of established chemotherapy. Histone deacetylase 6 (HDAC6) overexpression, commonly found in cancer, is acknowledged as a driver of cellular growth, and inhibiting HDACs holds promise in improving radiotherapeutic efficacy. Downregulation of HDAC6 facilitates the degradation of β-catenin. This protein is a key element in the Wnt/β-catenin signalling pathway, contributing to the progression of meningiomas. Methods: In order to elucidate the associations and therapeutic potential of HDAC6 inhibitors (HDAC6i) in conjunction with RT, we administered Cay10603, HDAC6i, to both immortalised and patient-derived meningioma cells prior …
Runx2 Regulates Peripheral Nerve Regeneration To Promote Schwann Cell Migration And Re-Myelination, Rong Hu, Xinpeng Dun, Lolita Singh, Matthew C. Banton
Runx2 Regulates Peripheral Nerve Regeneration To Promote Schwann Cell Migration And Re-Myelination, Rong Hu, Xinpeng Dun, Lolita Singh, Matthew C. Banton
School of Biomedical Sciences
Runx2 is a major regulator of osteoblast differentiation and function; however, the role of Runx2 in peripheral nerve repair is unclear. Here, we analyzed Runx2 expression following injury and found that it was specifically up-regulated in Schwann cells. Furthermore, using Schwann cell-specific Runx2 knockout mice, we studied peripheral nerve development and regeneration and found that multiple steps in the regeneration process following sciatic nerve injury were Runx2-dependent. Changes observed in Runx2 knockout mice include increased proliferation of Schwann cells, impaired Schwann cell migration and axonal regrowth, reduced re-myelination of axons, and a block in macrophage clearance in the late stage …
Animal Personality And Sentience As Distinct Concepts, Mark Briffa
Animal Personality And Sentience As Distinct Concepts, Mark Briffa
School of Biological and Marine Sciences
Owens et al (2024) discuss how knowledge of both animal personality and sentience in target populations can be leveraged to enhance wildlife conservation programmes. In this commentary I expand on the distinction between these two concepts. Behavioural differences should be considered broadly across conservation programmes, not just those involving species deemed sentient.
Investigating The Diversity In Physiological, And Molecular Responses Of Wheat (Triticum Aestivum L.) Genotypes Under Cadmium Stress, Haitham Mokhles Saad Khatlan, Mohammed Hamdan Al-Issawi, Hail Rihan
Investigating The Diversity In Physiological, And Molecular Responses Of Wheat (Triticum Aestivum L.) Genotypes Under Cadmium Stress, Haitham Mokhles Saad Khatlan, Mohammed Hamdan Al-Issawi, Hail Rihan
School of Biological and Marine Sciences
Heavy metal toxicity is a real threat to the environment, crop productivity, and the health of humans and their animals, especially when the toxicity enters the food chain. This study investigates the effect of cadmium on the physiological and molecular levels of ten introduced wheat genotypes. Genotypes were stressed by cadmium (75 mg.L-1) in comparison with unstressed treatment to highlight their response to the cadmium. The experiment was laid out as a factorial arrangement in RCBD, with three replicates. The genotypes included in this study varied in their response to cadmium stress during the laboratory tests. Notably, genotype …
Obituary: Prof. Donovan P Kelly (1940-2024), With A Review Of His Life's Work In Microbial Sulfur Metabolism, Autotrophy And C1 Metabolism, Rich Boden
School of Biological and Marine Sciences
No abstract provided.
Evaluating The Use Of The Mobile Electrocardiogram Technology Kardiamobile™ In Community Settings: An Online Survey, Aimee Emmett, Bridie Kent, Alison James, Jane March-Mcdonald
Evaluating The Use Of The Mobile Electrocardiogram Technology Kardiamobile™ In Community Settings: An Online Survey, Aimee Emmett, Bridie Kent, Alison James, Jane March-Mcdonald
School of Nursing and Midwifery
Background: In response to issues identified by community healthcare professionals (HCPs), including difficulty in routinely recording electrocardiograms (ECGs) at the time of their assessments with the population of patients referred to as ‘housebound’, one National Health Service (NHS) Trust adopted the mobile ECG technology; KardiaMobile™, supported by the Academic Health and Science Network (AHSN), in 2017–2018. The use and uptake of this technology were evaluated and are reported in this paper. Methods: A cross-sectional, mixed-methods online survey was conducted from August 2021 to October 2021. The respondents were a convenience sample of HCPs using KardiaMobile™ to detect atrial fibrillation (AF) …
New Valproate Regulations, Informed Choice And Seizure Risk, Heather Angus-Leppan, Rachel Arkell, Lance Watkins, Dominic Heaney, Paul Cooper, Rohit Shankar
New Valproate Regulations, Informed Choice And Seizure Risk, Heather Angus-Leppan, Rachel Arkell, Lance Watkins, Dominic Heaney, Paul Cooper, Rohit Shankar
Peninsula Medical School
Valproate is the most effective medication for generalised epilepsies, and several specific epilepsy syndromes. For some people, it will be the only medication to establish seizure remission, and withdrawing it carries risks of seizure recurrence and Sudden Unexpected Death in Epilepsy (SUDEP). It is also of proven efficacy for bipolar disorder and migraine prevention.Guidelines based on observational and epidemiological studies stress that maternal valproate related teratogenicity and neurodevelopmental effects are significantly higher than for other antiseizure medications (ASMs). It should, therefore, only be used if other medications are ineffective and after balancing the teratogenicity risk. Regulatory restrictions have changed prescribing …
The Forgotten Forests: Incorporating Temperate Peat-Forming Wet Woodlands As Nature-Based Solutions Into Policy And Practice, Alice M. Milner, Andy J. Baird, Scott J. Davidson, Emily R. Lines, Dan Abrahams, Crystal A.E. Ahiable, Nadia Barsoum, Marion Bryant, Emma Dear, Iain Diack, Emma Duley, Adam Noach, Thomas P. Roland, David Smedley
The Forgotten Forests: Incorporating Temperate Peat-Forming Wet Woodlands As Nature-Based Solutions Into Policy And Practice, Alice M. Milner, Andy J. Baird, Scott J. Davidson, Emily R. Lines, Dan Abrahams, Crystal A.E. Ahiable, Nadia Barsoum, Marion Bryant, Emma Dear, Iain Diack, Emma Duley, Adam Noach, Thomas P. Roland, David Smedley
School of Geography, Earth and Environmental Sciences
Peat-forming wet woodlands (forested wetlands) are naturally occurring carbon-dense ecosystems that have considerable potential to form an important part of net zero woodland establishment and peatland strategies, as well as provide crucial co-benefits to restore biodiversity and regulate hydrological systems. Despite their potential, temperate peat-forming wet woodlands have been widely lost, are critically understudied and are being overlooked in land-use strategies. Unlike temperate ‘dry’ woodlands, some wet woodlands are peat forming and can store large amounts of carbon below-ground in peat in addition to the carbon in the tree biomass. The complex structure of these peat-forming wet woodlands creates high …
Redefining Arctic Boundaries In A Changing Climate: Interdisciplinary Perspectives On Governance Strategies, Llucia Mascorda-Cabre
Redefining Arctic Boundaries In A Changing Climate: Interdisciplinary Perspectives On Governance Strategies, Llucia Mascorda-Cabre
School of Biological and Marine Sciences
The Arctic rapidly transforms due to global warming and increased human activities, triggering complex changes at unprecedented speeds that challenge conventional institutional responses. We analyse these changes through the lenses of social, political, and environmental boundaries and investigate their impacts on both inhabitants' livelihoods and the region's political framework. Employing an interdisciplinary approach, we highlight the complexities of understanding the interplay among global, regional, and local dynamics in an era where human and non-human aspects are entwined. Our analysis concentrates on three areas: definition of the Arctic; legal disputes concerning the waters around the Svalbard Archipelago; evolving natural hazards and …
Codesign Principles For The Effective Development Of Digital Heritage Extended Reality Systems For Health Interventions In Rural Communities, Alejandro Veliz Reyes, Marius N. Varga, Hannah Bradwell, Rory Baxter, Ray B. Jones, Daniel Maudlin
Codesign Principles For The Effective Development Of Digital Heritage Extended Reality Systems For Health Interventions In Rural Communities, Alejandro Veliz Reyes, Marius N. Varga, Hannah Bradwell, Rory Baxter, Ray B. Jones, Daniel Maudlin
School of Art, Design and Architecture
We present a methodological, theoretical, and technological outline of codesign principles for the effective development of digital heritage extended reality systems for health and care. The paper is based on two large-scale research projects involving ageing in rural and coastal communities, focused on the codesign of extended reality systems to stimulate new forms of access to local heritage sites with potential impact on health outcomes. Our approach stems from a multi-disciplinary collaboration between health, digital design, and heritage specialists, and suggests ways to reconcile diverging forms of knowledge production, such as our ‘researcher in residence’ methodology and the place-based complexities …
Predictors Of Short-Term Anxiety Outcome In Subthalamic Stimulation For Parkinson’S Disease, Anna Sauerbier, Johanna Herberg, Vasilija Stopic, Philipp A. Loehrer, Keyoumars Ashkan, Alexandra Rizos, Stefanie T. Jost, Jan Niklas Petry-Schmelzer, Alexandra Gronostay, Christian Schneider, Veerle Visser-Vandewalle, Julian Evans, Christopher Nimsky, Gereon R. Fink, Angelo Antonini, Pablo Martinez-Martin, Monty Silverdale, Daniel Weintraub, Anette Schrag, K. Ray Chaudhuri, Lars Timmermann, Haidar S. Dafsari, Charles Adler, Roongroj Bhidayasiri, Per Borghammer, Paolo Barone, David J. Brooks, Richard Brown, Marc Cantillon, Camille Carroll
Predictors Of Short-Term Anxiety Outcome In Subthalamic Stimulation For Parkinson’S Disease, Anna Sauerbier, Johanna Herberg, Vasilija Stopic, Philipp A. Loehrer, Keyoumars Ashkan, Alexandra Rizos, Stefanie T. Jost, Jan Niklas Petry-Schmelzer, Alexandra Gronostay, Christian Schneider, Veerle Visser-Vandewalle, Julian Evans, Christopher Nimsky, Gereon R. Fink, Angelo Antonini, Pablo Martinez-Martin, Monty Silverdale, Daniel Weintraub, Anette Schrag, K. Ray Chaudhuri, Lars Timmermann, Haidar S. Dafsari, Charles Adler, Roongroj Bhidayasiri, Per Borghammer, Paolo Barone, David J. Brooks, Richard Brown, Marc Cantillon, Camille Carroll
Peninsula Medical School
The effects of subthalamic nucleus deep brain stimulation (STN-DBS) on anxiety in Parkinson’s disease (PD) are understudied. We identified clinical predictors of STN-DBS effects on anxiety in this study. In this prospective, open-label, multicentre study, we assessed patients with anxiety undergoing STN-DBS for PD preoperatively and at 6-month follow-up postoperatively. We assessed the Hospital Anxiety and Depression Scale (HADS-anxiety and depression subscales), Unified PD Rating Scale-motor examination, Scales for Outcomes in PD-motor (SCOPA-M)-activities of daily living (ADL) and -motor complications, Non-Motor Symptom Scale (NMSS), PDQuestionnaire-8 (PDQ-8), and levodopa-equivalent daily dose. We tested changes at follow-up with Wilcoxon signed-rank test and …
Elucidating The Migrations Of European Seabass From The Southern North Sea Using Mark-Recapture Data, Acoustic Telemetry And Data Storage Tags, Jolien Goossens, Mathieu Woillez, Serena Wright, Jena E. Edwards, Georges De Putter, Els Torreele, Pieterjan Verhelst, Emma Sheehan, Tom Moens, Jan Reubens
Elucidating The Migrations Of European Seabass From The Southern North Sea Using Mark-Recapture Data, Acoustic Telemetry And Data Storage Tags, Jolien Goossens, Mathieu Woillez, Serena Wright, Jena E. Edwards, Georges De Putter, Els Torreele, Pieterjan Verhelst, Emma Sheehan, Tom Moens, Jan Reubens
School of Biological and Marine Sciences
The movement ecology of European seabass, Dicentrarchus labrax, remains poorly understood, especially in the northern ranges of its distribution. To investigate migration patterns of seabass from the southern North Sea, we combined data from different projects from four countries using various tagging techniques. This resulted in 146 recaptures (out of 5598 externally marked seabass), 138 detected animals (out of 162 seabass fitted with an acoustic transmitter) and 76 archived depth and temperature series (out of 323 seabass with an archival tag). Using geolocation modelling, we distinguished different migration strategies, whereby individual fish migrated to the eastern English Channel (15.1%), the …
Men’S Perceptions Of Beardedness In A Hispanic And Iranian Sample: The Role Of Intrasexual Competition On Evaluations Of Attractiveness, Masculinity, And Fighting Ability, Ray Garza, Reza Afhami, Farid Pazhoohi
Men’S Perceptions Of Beardedness In A Hispanic And Iranian Sample: The Role Of Intrasexual Competition On Evaluations Of Attractiveness, Masculinity, And Fighting Ability, Ray Garza, Reza Afhami, Farid Pazhoohi
School of Psychology
Facial hair is suggested to have evolved partly through female mate choice, enhancing men's attractiveness, and is also linked to forms of intrasexual competition, including aggression, masculinity, and dominance. The current research investigated how these perceptions vary across cultures, focusing on Iranian and Hispanic men's views on beardedness. The findings revealed a preference for shorter beards when considering a man's attractiveness, whereas longer beards were associated with masculinity and fighting ability. Cultural differences significantly influenced these perceptions, with Hispanic men rating beards of all lengths more favorably than Iranian men. The study also explored men’s dispositional level of intrasexual competition …
Knowledge Gaps In Quantifying The Climate Change Response Of Biological Storage Of Carbon In The Ocean, Stephanie Henson, Chelsey A. Baker, Paul Halloran, Abigail Mcquatters-Gollop, Stuart Painter, Alban Planchat, Alessandro Tagliabue
Knowledge Gaps In Quantifying The Climate Change Response Of Biological Storage Of Carbon In The Ocean, Stephanie Henson, Chelsey A. Baker, Paul Halloran, Abigail Mcquatters-Gollop, Stuart Painter, Alban Planchat, Alessandro Tagliabue
School of Biological and Marine Sciences
The ocean is responsible for taking up approximately 25% of anthropogenic CO2 emissions and stores >50 times more carbon than the atmosphere. Biological processes in the ocean play a key role, maintaining atmospheric CO2 levels approximately 200 ppm lower than they would otherwise be. The ocean's ability to take up and store CO2 is sensitive to climate change, however the key biological processes that contribute to ocean carbon storage are uncertain, as are how those processes will respond to, and feedback on, climate change. As a result, biogeochemical models vary widely in their representation of relevant processes, …
Artificial Light And Cloud Cover Interact To Disrupt Celestial Migrations At Night, Leo M. Burke, Thomas Davies, David Wilcockson, Stuart Jenkins, Amy Ellison
Artificial Light And Cloud Cover Interact To Disrupt Celestial Migrations At Night, Leo M. Burke, Thomas Davies, David Wilcockson, Stuart Jenkins, Amy Ellison
School of Biological and Marine Sciences
The growth of human activity and infrastructure has led to an unprecedented rise in the use of Artificial Light at Night (ALAN) with demonstrable impacts on ecological communities and ecosystem services. However, there remains very little information on how ALAN interacts with or obscures light from celestial bodies, which provide vital orientating cues in a number of species. Furthermore, no studies to date have examined how climatic conditions such as cloud cover, known to influence the intensity of skyglow, interact with lunar irradiance and ALAN over the course of a lunar cycle to alter migratory abilities of species. Our night-time …
Satellite-Derived Sandy Shoreline Trends And Interannual Variability Along The Atlantic Coast Of Europe, Bruno Castelle, Etiënne Kras, Gerd Masselink, Tim Scott, Aikaterini Konstantinou, Arjen Luijendijk
Satellite-Derived Sandy Shoreline Trends And Interannual Variability Along The Atlantic Coast Of Europe, Bruno Castelle, Etiënne Kras, Gerd Masselink, Tim Scott, Aikaterini Konstantinou, Arjen Luijendijk
School of Biological and Marine Sciences
Monitoring sandy shoreline evolution from years to decades is critical to understand the past and predict the future of our coasts. Optical satellite imagery can now infer such datasets globally, but sometimes with large uncertainties, poor spatial resolution, and thus debatable outcomes. Here we validate and analyse satellite-derived-shoreline positions (1984–2021) along the Atlantic coast of Europe using a moving-averaged approach based on coastline characteristics, indicating conservative uncertainties of long-term trends around 0.4 m/year and a potential bias towards accretion. We show that west-facing open coasts are more prone to long-term erosion, whereas relatively closed coasts favor accretion, although most of …
Twelve Years Of Drug Prioritization To Help Accelerate Disease Modification Trials In Parkinson’S Disease: The International Linked Clinical Trials Initiative, Camille Carroll
Peninsula Medical School
In 2011, the UK medical research charity Cure Parkinson’s set up the international Linked Clinical Trials (iLCT) committee to help expedite the clinical testing of potentially disease modifying therapies for Parkinson’s disease (PD). The first committee meeting was held at the Van Andel Institute in Grand Rapids, Michigan in 2012. This group of PD experts has subsequently met annually to assess and prioritize agents that may slow the progression of this neurodegenerative condition, using a systematic approach based on preclinical, epidemiological and, where possible, clinical data. Over the last 12 years, 171 unique agents have been evaluated by the iLCT …
Early Threads Of Connection. Probing Infants' Understanding Of Caregiving Relationships, Christina Steele, Megan Richardson, Denis Tatone, Ashley Thomas
Early Threads Of Connection. Probing Infants' Understanding Of Caregiving Relationships, Christina Steele, Megan Richardson, Denis Tatone, Ashley Thomas
School of Psychology
Despite the centrality of caregiving relationships in the lives of infants, little is known about whether and how infants represent these relationships characterized by strong attachment and asymmetry in obligation and skills. The current studies (N=95) investigate whether 8-to-10-month-old infants attend to two cues‚Äîaffiliative touch and physical size‚Äîto predict who will respond to distress. In Study 1 (n=49), infants expected larger characters to respond to the emotional needs of smaller characters, only when they saw affiliative touch (proportion looking time at large character: BF10=6.72). In Study 2 (n=46), they did not expect smaller characters to respond to larger characters (proportion …
Infants Expect An Agent To Choose A Goal That Can Be Reached At A Lower Cost, Laura Schingloff-Nemecz, Denis Tatone, Barbara Pomiechowska, Gergely Csibra
Infants Expect An Agent To Choose A Goal That Can Be Reached At A Lower Cost, Laura Schingloff-Nemecz, Denis Tatone, Barbara Pomiechowska, Gergely Csibra
School of Psychology
According to prominent accounts of early actionunderstanding, infants’ interpretation of others’ actions isundergirded by an assumption of utility maximization.However, it is unclear whether this assumption applies only toselection among actions or also to selection among goals. Here,using an eye-tracking paradigm, we investigated whether 14-to 16-month-old infants would predict an agent to choose alower-cost option when faced with two identical outcomes thatcould be reached at different costs. Infants directed more looksto the lower-cost option, and this effect was not merely due tovisual saliency. These findings corroborate the proposal thatinfants rely on utility maximization when reasoning about anagent’s likely goal and provide …
Ecotoxicological Impacts Of Landfill Sites: Towards Risk Assessment, Mitigation Policies And The Role Of Artificial Intelligence, Krishna Gautam, Namrata Pandey, Dhvani Yadav, Ramakrishnan Parthasarathi, Andrew Turner, Sadasivam Anbumani, Awadhesh N. Jha
Ecotoxicological Impacts Of Landfill Sites: Towards Risk Assessment, Mitigation Policies And The Role Of Artificial Intelligence, Krishna Gautam, Namrata Pandey, Dhvani Yadav, Ramakrishnan Parthasarathi, Andrew Turner, Sadasivam Anbumani, Awadhesh N. Jha
School of Geography, Earth and Environmental Sciences
Waste disposal in landfills remains a global concern. Despite technological developments, landfill leachate poses a hazard to ecosystems and human health since it acts as a secondary reservoir for legacy and emerging pollutants. This study provides a systematic and scientometric review of the nature and toxicity of pollutants generated by landfills and means of assessing their potential risks. Regarding human health, unregulated waste disposal and pathogens in leachate are the leading causes of diseases reported in local populations. Both in vitro and in vivo approaches have been employed in the ecotoxicological risk assessment of landfill leachate, with model organisms ranging …
Soil Saturation Limits Early Oak Establishment In Upland Pastures For Restoration Of Atlantic Oak Woodlands, Thomas R. Murphy, Mick E. Hanley, Jon S. Ellis, Paul H. Lunt
Soil Saturation Limits Early Oak Establishment In Upland Pastures For Restoration Of Atlantic Oak Woodlands, Thomas R. Murphy, Mick E. Hanley, Jon S. Ellis, Paul H. Lunt
School of Geography, Earth and Environmental Sciences
With woodland expansion providing a nature-based solution to help tackle anthropogenic climate change, the persistence and regeneration of fragmented Atlantic oak woodland is a critical feature of the wilding of uplands and conservation of Temperate Rainforests in Western Europe. Predicted shifts in precipitation with climate change are likely to be a major determinant of tree recruitment here, yet our understanding of the threshold effects of high soil moisture on oak establishment is limited, particularly at early-life-history stages when trees are most vulnerable. We address this gap in knowledge by investigating the effect of soil saturation states on; 1) the capacity …
Physicochemical And Metagenomic Analysis Of Samples From The Roman Baths (Bath, Uk) Reveals High Bacterial And Archaeal Diversity And A Potential For Antimicrobial Discovery, Enus Fina, Michele Kiernan, Bonnie Whatmough, Nathaniel J. Clark, Jazmin Conway, Iga W. Wieczorek, Laura Carey, Zofia Matyjaszkiewicz, Philip J. Warburton, Mathew Upton, Lee P. Hutt
Physicochemical And Metagenomic Analysis Of Samples From The Roman Baths (Bath, Uk) Reveals High Bacterial And Archaeal Diversity And A Potential For Antimicrobial Discovery, Enus Fina, Michele Kiernan, Bonnie Whatmough, Nathaniel J. Clark, Jazmin Conway, Iga W. Wieczorek, Laura Carey, Zofia Matyjaszkiewicz, Philip J. Warburton, Mathew Upton, Lee P. Hutt
School of Biological and Marine Sciences
Antimicrobial resistance of pathogenic bacteria to currently used antibiotics killed an estimated 1.27 million people in 2019 and it is believed that this toll will increase to 10 million per year by 2050. This remains one of the most urgent threats to human health and the hunt for novel antimicrobial natural products (NPs) from microorganisms is essential in efforts to combat this threat, but recent efforts have been unsuccessful. The investigation of extreme ecological niches, such as hot springs, has gained recent interest due to their unique ecosystems, increasing the chance for novel antimicrobial NP discovery. The Roman Baths (Bath) …
Acclimation To Warming But Not Hypoxia Alters Thermal Tolerance And Metabolic Sensitivity In An Estuarine Crustacean, Rebecca Bridge, Manuela Truebano, Michael Collins
Acclimation To Warming But Not Hypoxia Alters Thermal Tolerance And Metabolic Sensitivity In An Estuarine Crustacean, Rebecca Bridge, Manuela Truebano, Michael Collins
School of Biological and Marine Sciences
Coastal species are challenged by multiple anthropogenic stressors. Plasticity may buffer the effects of environmental change, but investigation has largely been restricted to single-stressor performance. Multistressor studies have often been short-term and relatively less is known about the consequences of plasticity under one stressor for performance under another. Here, we aimed to test for the effects of thermal or hypoxic acclimation on thermal tolerance in the amphipod Gammarus chevreuxi. Animals were chronically exposed to raised temperature or hypoxia prior to determination of upper thermal limits and routine metabolic rate (RMR). Warm acclimation increased all metrics of thermal tolerance, but hypoxic …
Acceptance And Commitment Therapy Plus Usual Care For Improving Quality Of Life In People With Motor Neuron Disease (Commend): A Multicentre, Parallel, Randomised Controlled Trial In The Uk, Rebecca L. Gould, Christopher J. Mcdermott, Benjamin J. Thompson, Charlotte V. Rawlinson, Matt Bursnall, Mike Bradburn, Pavithra Kumar, Emily J. Turton, David A. White, Marc A. Serfaty, Christopher D. Graham, Lance M. Mccracken, Laura H. Goldstein, Ammar Al-Chalabi, Richard W. Orrell, Tim Williams, Rupert Noad, Idris Baker, Christina Faull, Thomas Lambert, Suresh K. Chhetri, John Ealing, Anthony Hanratty, Aleksandar Radunovic, Nushan Gunawardana, Gail Meadows, George H. Gorrie, Tracey Young, Vanessa Lawrence, Cindy Cooper
Acceptance And Commitment Therapy Plus Usual Care For Improving Quality Of Life In People With Motor Neuron Disease (Commend): A Multicentre, Parallel, Randomised Controlled Trial In The Uk, Rebecca L. Gould, Christopher J. Mcdermott, Benjamin J. Thompson, Charlotte V. Rawlinson, Matt Bursnall, Mike Bradburn, Pavithra Kumar, Emily J. Turton, David A. White, Marc A. Serfaty, Christopher D. Graham, Lance M. Mccracken, Laura H. Goldstein, Ammar Al-Chalabi, Richard W. Orrell, Tim Williams, Rupert Noad, Idris Baker, Christina Faull, Thomas Lambert, Suresh K. Chhetri, John Ealing, Anthony Hanratty, Aleksandar Radunovic, Nushan Gunawardana, Gail Meadows, George H. Gorrie, Tracey Young, Vanessa Lawrence, Cindy Cooper
Peninsula Medical School
Background: Motor neuron disease is a progressive, fatal neurodegenerative disease for which there is no cure. Acceptance and Commitment Therapy (ACT) is a psychological therapy incorporating acceptance, mindfulness, and behaviour change techniques. We aimed to evaluate the effectiveness of ACT plus usual care, compared with usual care alone, for improving quality of life in people with motor neuron disease. Methods: We conducted a parallel, multicentre, two-arm randomised controlled trial in 16 UK motor neuron disease care centres or clinics. Eligible participants were aged 18 years or older with a diagnosis of definite or laboratory-supported probable, clinically probable, or possible familial …
Outcome Measures In Psychiatry, Rohit Shankar
Outcome Measures In Psychiatry, Rohit Shankar
Peninsula Medical School
Measuring what medical care does to improve the lives of patients must be at theheart of what we do (Ryland, Carlile and Kingdon, 2021). A crucial part of achievingthe ambition of parity between physical and mental health is for psychiatry to embrace,use and promote outcome measures as a way of demonstrating the positive impactthat well-resourced and structured mental health services can have for patients, theirfamilies, and society more widely.The Royal College of Psychiatrists strongly endorses and recommends the routine useof patient- and clinician-rated outcome measures in psychiatric practice (Tracy et al.,2022). Outcome measurement can improve care planning, progress-tracking, qualityimprovement, service …