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Articles 5641 - 5670 of 6794
Full-Text Articles in Entire DC Network
Emancipating The Many: A Practice Led Investigation Into Emergent Paradigms Of Immediate Political Action, Wolfgang Fiel
Emancipating The Many: A Practice Led Investigation Into Emergent Paradigms Of Immediate Political Action, Wolfgang Fiel
Other Faculty of Arts, Humanities and Business Theses
The immediate catalyst for having taken up this study was the violent outbreak of weeks of public unrest in the Paris banlieus in the wake of the shooting of young man on the run from the police on October 27 2005. The obvious inability of local municipalities and police forces to explain, let alone to anticipate the swelling discontent with a system which is generally assumed to work effectively and to benefit all has led me to the assumption that we have entered a stage where the concept of representational democracy is seriously compromised. The sheer scale or projected growth …
The Production Of Cauliflower Microshoots Using Curd Meristematic Tissues And Hypocotyl–Derived Callus., Hz Rihan, M Al-Shamari, Mp Fuller
The Production Of Cauliflower Microshoots Using Curd Meristematic Tissues And Hypocotyl–Derived Callus., Hz Rihan, M Al-Shamari, Mp Fuller
School of Biological and Marine Sciences
The capacity for microshoot production from cauliflower was investigated applying two different protocols. In the first, cauliflower curd meristematic tissue was used as a source of explants. The meristematic layer was shaved off and the clusters produced were homogenised using a commercial blender. In terms of its effect on the number and viability of microshoots, the use of 30 s blending duration treatment was found to be optimal between several treatments tested in the range 15 to 120 sec. Explants were cultivated in agitated S23 (MS (Murashige and Skoog, 1962) + 3 % sucrose) liquid media supplemented with different combinations …
The Effect Of Geographical Scale Of Sampling On Dna Barcoding., Johannes Bergsten, David T. Bilton, Tomochika Fujisawa, Miranda Elliott, Michael T. Monaghan, Michael Balke, Lars Hendrich, Joja Geijer, Jan Herrmann, Garth N. Foster, Ignacio Ribera, Anders N. Nilsson, Timothy G. Barraclough, Alfried P. Vogler
The Effect Of Geographical Scale Of Sampling On Dna Barcoding., Johannes Bergsten, David T. Bilton, Tomochika Fujisawa, Miranda Elliott, Michael T. Monaghan, Michael Balke, Lars Hendrich, Joja Geijer, Jan Herrmann, Garth N. Foster, Ignacio Ribera, Anders N. Nilsson, Timothy G. Barraclough, Alfried P. Vogler
School of Biological and Marine Sciences
Eight years after DNA barcoding was formally proposed on a large scale, CO1 sequences are rapidly accumulating from around the world. While studies to date have mostly targeted local or regional species assemblages, the recent launch of the global iBOL project (International Barcode of Life), highlights the need to understand the effects of geographical scale on Barcoding's goals. Sampling has been central in the debate on DNA Barcoding, but the effect of the geographical scale of sampling has not yet been thoroughly and explicitly tested with empirical data. Here, we present a CO1 data set of aquatic predaceous diving beetles …
A Study Of Marine Benthic Algae Along A Natural Carbon Dioxide Gradient, Vivienne R Johnson
A Study Of Marine Benthic Algae Along A Natural Carbon Dioxide Gradient, Vivienne R Johnson
School of Biological and Marine Sciences Theses
Increasing atmospheric CO2 is causing unprecedented changes in seawater chemistry, yet the uncertainty of the ecological response to these projected changes, termed ‘ocean acidification’, remains considerable at present. To predict the effects of these changes, we need to improve our understanding of the responses of marine primary producers since these drive biogeochemical cycles and determine the structure and function of benthic habitats. The majority of experiments on the effects of ocean acidification on photoautrophs to date have mainly focused on oceanic microalgae, leaving benthic assemblages largely overlooked. Carbon dioxide vents are providing a means for examining and predicting the impacts …
Fabrication And Mechanical Properties Of Chitosan Composite Membrane Containing Hydroxyapatite Particles, Hr Le, S Qu, Re Mackay, R Rothwell
Fabrication And Mechanical Properties Of Chitosan Composite Membrane Containing Hydroxyapatite Particles, Hr Le, S Qu, Re Mackay, R Rothwell
School of Biological and Marine Sciences
This paper described the development of chitosan composites containing precipitated hydroxyapatite particles for potential applications in orthopaedic surgery or waste water treatment. The synthetic process and morphology of hydroxyapatite were reported. The effects of hydroxyapatite content on the microstructure and mechanical properties of composites were investigated. It was found that the Young’s Modulus of the composites decreases with hydroxyapatite content while the failure strength and strain increase with the hydroxyapatite content.
Ethnic Group Affiliation And Social Exclusion In Cornwall; Analysis, Adjustment And Extension Of The 2001 England And Wales Census Data, Kerryn Husk
School of Law, Humanities and Social Sciences Theses
This thesis provides a critical understanding of the size and relative position of the Cornish in Cornwall, a county in the south-west of the UK. Cornwall is a region which has experienced increased levels of disadvantage for a prolonged period of time. The indigenous people, whilst seeing a rise in their inclusion in ethnicity variables in the region, have remained under-researched in terms of their socio-economic position relative to the non-Cornish in the same geographic area. This thesis addresses this gap in the literature and represents the first in-depth examination of the group. The 2001 Census included an option to …
Neurofibromatosis 2011: A Report Of The Children's Tumor Foundation Annual Meeting., Michel Kalamarides, Maria T. Acosta, Dusica Babovic-Vuksanovic, Olli Carpen, Karen Cichowski, Dg Evans, Filippo Giancotti, Co Hanemann, David Ingram, Alison C. Lloyd, Debra A. Mayes, Ludwine Messiaen, Helen Morrison, Kathryn North, Roger Packer, Duojia Pan, Anat Stemmer-Rachamimov, Meena Upadhyaya, David Viskochil, Margret R. Wallace, Kim Hunter-Schaedle, Nancy Ratner
Neurofibromatosis 2011: A Report Of The Children's Tumor Foundation Annual Meeting., Michel Kalamarides, Maria T. Acosta, Dusica Babovic-Vuksanovic, Olli Carpen, Karen Cichowski, Dg Evans, Filippo Giancotti, Co Hanemann, David Ingram, Alison C. Lloyd, Debra A. Mayes, Ludwine Messiaen, Helen Morrison, Kathryn North, Roger Packer, Duojia Pan, Anat Stemmer-Rachamimov, Meena Upadhyaya, David Viskochil, Margret R. Wallace, Kim Hunter-Schaedle, Nancy Ratner
Peninsula Medical School
The 2011 annual meeting of the Children's Tumor Foundation, the annual gathering of the neurofibromatosis (NF) research and clinical communities, was attended by 330 participants who discussed integration of new signaling pathways into NF research, the appreciation for NF mutations in sporadic cancers, and an expanding pre-clinical and clinical agenda. NF1, NF2, and schwannomatosis collectively affect approximately 100,000 persons in US, and result from mutations in different genes. Benign tumors of NF1 (neurofibroma and optic pathway glioma) and NF2 (schwannoma, ependymoma, and meningioma) and schwannomatosis (schwannoma) can cause significant morbidity, and there are no proven drug treatments for any form …
Molecular Diversity Of Maerl-Forming Corallines (Corallinales, Rhodophyta), Jj Hernandez-Kantun, F Rindi, R Riosmena-Rodriguez, Ca Maggs, Jm Hall-Spencer, V Pena
Molecular Diversity Of Maerl-Forming Corallines (Corallinales, Rhodophyta), Jj Hernandez-Kantun, F Rindi, R Riosmena-Rodriguez, Ca Maggs, Jm Hall-Spencer, V Pena
School of Biological and Marine Sciences
No abstract provided.
Guided Self-Help Concreteness Training As An Intervention For Major Depression In Primary Care: A Phase Ii Randomized Controlled Trial., E. R. Watkins, R. S. Taylor, R. Byng, C. Baeyens, R. Read, K. Pearson, L. Watson
Guided Self-Help Concreteness Training As An Intervention For Major Depression In Primary Care: A Phase Ii Randomized Controlled Trial., E. R. Watkins, R. S. Taylor, R. Byng, C. Baeyens, R. Read, K. Pearson, L. Watson
Peninsula Medical School
BACKGROUND: The development of widely accessible, effective psychological interventions for depression is a priority. This randomized trial provides the first controlled data on an innovative cognitive bias modification (CBM) training guided self-help intervention for depression. METHOD: One hundred and twenty-one consecutively recruited participants meeting criteria for current major depression were randomly allocated to treatment as usual (TAU) or to TAU plus concreteness training (CNT) guided self-help or to TAU plus relaxation training (RT) guided self-help. CNT involved repeated practice at mental exercises designed to switch patients from an unhelpful abstract thinking habit to a helpful concrete thinking habit, thereby targeting …
Statins In Unconventional Secretion Of Insulin-Degrading Enzyme And Degradation Of The Amyloid-Β Peptide, K Glebov, J Walter
Statins In Unconventional Secretion Of Insulin-Degrading Enzyme And Degradation Of The Amyloid-Β Peptide, K Glebov, J Walter
Peninsula Medical School
Population-based studies demonstrated that statins might decrease the risk of developing Alzheimer’s disease (AD). Statins inhibit the 3-hydroxy-3-methyl-glutaryl-coenzyme-A reductase and thereby de novo synthesis of cholesterol. Cell culture and animal studies indicated that cholesterol affects the proteolytic processing of the amyloid precursor protein and the generation of amyloid-β (Aβ). Recently, we have demonstrated that statins can also stimulate the degradation of Aβ. The statin-induced clearance of Aβ could be attributed to increased release of the insulin-degrading enzyme (IDE) via an exosome-related unconventional secretory pathway. Interestingly, this statin-induced secretion of exosome-associated IDE was independent of cellular cholesterol concentrations, but rather caused …
Walking As A Meaningful Leisure Occupation: The Implications For Occupational Therapy, R Wensley, A Slade
Walking As A Meaningful Leisure Occupation: The Implications For Occupational Therapy, R Wensley, A Slade
School of Health Professions
Introduction: In response to growing interest in leisure in occupational therapy and the importance of understanding how occupations maintain, enhance and promote health and wellbeing, a qualitative phenomenological study was conducted to explore the experiences of walking for leisure. Method: Six healthy student participants, identified as regular walkers, were interviewed using a semi-structured format. Data were analysed following interpretative phenomenological analysis methodology. Findings: Participants expressed how and why walking was meaningful to them; the four main themes were social connectedness, wellbeing, connection to nature and achievement from a challenge. Findings suggest that occupational therapists could use walking and leisure occupations …
Palaeolimnological Evidence For An East-West Climate See-Saw In The Mediterranean Since Ad 900, Neil Roberts, Ana Moreno, Bl Valero-Garces, Corella J Pablo, Matthew Jones, Samantha Allcock, Jessie Woodbridge, M Morellon, Juerg Luterbacher, Elena Xoplaki, M Turkes
Palaeolimnological Evidence For An East-West Climate See-Saw In The Mediterranean Since Ad 900, Neil Roberts, Ana Moreno, Bl Valero-Garces, Corella J Pablo, Matthew Jones, Samantha Allcock, Jessie Woodbridge, M Morellon, Juerg Luterbacher, Elena Xoplaki, M Turkes
More Faculty of Science and Engineering Research
No abstract provided.
Oral Health And Pathology: A Macrophage Account., Rebecca Merry, Louise Belfield, Paul Mcardle, Andrew Mclennan, Stjohn Crean, Andrew Foey
Oral Health And Pathology: A Macrophage Account., Rebecca Merry, Louise Belfield, Paul Mcardle, Andrew Mclennan, Stjohn Crean, Andrew Foey
School of Biomedical Sciences
Macrophages are present in healthy oral mucosa and their numbers increase dramatically during disease. They can exhibit a diverse range of phenotypes characterised as a functional spectrum from pro-inflammatory to anti-inflammatory (regulatory) subsets. This review illustrates the role of these subsets in the oral inflammatory disease lichen planus, and the immunosuppressive disease oral squamous cell carcinoma (SCC). We conclude that the role of macrophages in driving progression in oral disease identifies them as potential therapeutic targets for a range of oral pathologies.
Assessing The Congruence Of Thermal Niche Estimations Derived From Distribution And Physiological Data. A Test Using Diving Beetles., David Sánchez-Fernández, Pedro Aragón, David T. Bilton, Jorge M. Lobo
Assessing The Congruence Of Thermal Niche Estimations Derived From Distribution And Physiological Data. A Test Using Diving Beetles., David Sánchez-Fernández, Pedro Aragón, David T. Bilton, Jorge M. Lobo
School of Biological and Marine Sciences
A basic aim of ecology is to understand the determinants of organismal distribution, the niche concept and species distribution models providing key frameworks to approach the problem. As temperature is one of the most important factors affecting species distribution, the estimation of thermal limits is crucially important for inferring range constraints. It is expectable that thermal physiology data derived from laboratory experiments and species' occurrences may express different aspects of the species' niche. However, there is no study systematically testing this prediction in a given taxonomic group while controlling by potential phylogenetic inertia. We estimate the thermal niches of twelve …
Community-Level Response Of Coastal Microbial Biofilms To Ocean Acidification In A Natural Carbon Dioxide Vent Ecosystem., Ian Lidbury, Vivienne Johnson, Jason M. Hall-Spencer, Colin B. Munn, Michael Cunliffe
Community-Level Response Of Coastal Microbial Biofilms To Ocean Acidification In A Natural Carbon Dioxide Vent Ecosystem., Ian Lidbury, Vivienne Johnson, Jason M. Hall-Spencer, Colin B. Munn, Michael Cunliffe
School of Biological and Marine Sciences
The impacts of ocean acidification on coastal biofilms are poorly understood. Carbon dioxide vent areas provide an opportunity to make predictions about the impacts of ocean acidification. We compared biofilms that colonised glass slides in areas exposed to ambient and elevated levels of pCO(2) along a coastal pH gradient, with biofilms grown at ambient and reduced light levels. Biofilm production was highest under ambient light levels, but under both light regimes biofilm production was enhanced in seawater with high pCO(2). Uronic acids are a component of biofilms and increased significantly with high pCO(2). Bacteria and Eukarya denaturing gradient gel electrophoresis …
Global Habitat Suitability Of Cold-Water Octocorals, Chris Yesson, Michelle L. Taylor, Derek P. Tittensor, Andrew J. Davies, John Guinotte, Amy Baco, Julie Black, Jason M. Hall-Spencer, Alex D. Rogers
Global Habitat Suitability Of Cold-Water Octocorals, Chris Yesson, Michelle L. Taylor, Derek P. Tittensor, Andrew J. Davies, John Guinotte, Amy Baco, Julie Black, Jason M. Hall-Spencer, Alex D. Rogers
School of Biological and Marine Sciences
No abstract provided.
210Pb-226Ra Chronology Reveals Rapid Growth Rate Of Madrepora Oculata And Lophelia Pertusa On World's Largest Cold-Water Coral Reef, P. Sabatier, J. L. Reyss, J. M. Hall-Spencer, C. Colin, N. Frank, N Tisnerat-Laborde, L. Bordier, E. Douville
210Pb-226Ra Chronology Reveals Rapid Growth Rate Of Madrepora Oculata And Lophelia Pertusa On World's Largest Cold-Water Coral Reef, P. Sabatier, J. L. Reyss, J. M. Hall-Spencer, C. Colin, N. Frank, N Tisnerat-Laborde, L. Bordier, E. Douville
School of Biological and Marine Sciences
No abstract provided.
Marine Bivalve Shell Geochemistry And Ultrastructure From Modern Low Ph Environments: Environmental Effect Versus Experimental Bias, S. Hahn, R. Rodolfo-Metalpa, E. Griesshaber, W. W. Schmahl, D. Buhl, J. M. Hall-Spencer, C. Baggini, K. T. Fehr, A. Immenhauser
Marine Bivalve Shell Geochemistry And Ultrastructure From Modern Low Ph Environments: Environmental Effect Versus Experimental Bias, S. Hahn, R. Rodolfo-Metalpa, E. Griesshaber, W. W. Schmahl, D. Buhl, J. M. Hall-Spencer, C. Baggini, K. T. Fehr, A. Immenhauser
School of Biological and Marine Sciences
No abstract provided.
The Behavioural Consequences Of Reduced Sea Water Ph In Decapod Crustaceans, Kate De La Haye
The Behavioural Consequences Of Reduced Sea Water Ph In Decapod Crustaceans, Kate De La Haye
School of Biological and Marine Sciences Theses
The studies presented in this thesis were designed to investigate the effects of reduced sea water pH on the behaviour of intertidal decapod crustaceans, both within the context of the variations occurring naturally in the pH of rock pool habitats, and in relation to predicted changes to ocean pH resulting from ocean acidification and potential carbon dioxide (CO2) leaks from carbon capture storage (CCS) sites. Recent studies on marine fish have shown behavioural disruptions as a result of increased CO2 concentrations in sea water and reduced pH, but the effects on crustaceans are as yet unknown. The first two studies …
The Role Of Insulin-Like Growth Factors Signaling In Merlin-Deficient Human Schwannomas., Sylwia Ammoun, M. Caroline Schmid, Natalia Ristic, Lu Zhou, David Hilton, Emanuela Ercolano, Camille Carroll, C. Oliver Hanemann
The Role Of Insulin-Like Growth Factors Signaling In Merlin-Deficient Human Schwannomas., Sylwia Ammoun, M. Caroline Schmid, Natalia Ristic, Lu Zhou, David Hilton, Emanuela Ercolano, Camille Carroll, C. Oliver Hanemann
Peninsula Medical School
Loss of the tumor suppressor merlin causes development of the tumors of the nervous system, such as schwannomas, meningiomas, and ependymomas occurring spontaneously or as part of a hereditary disease Neurofibromatosis Type 2 (NF2). Current therapies, (radio) surgery, are not always effective. Therefore, there is a need for drug treatments for these tumors. Schwannomas are the most frequent of merlin-deficient tumors and are hallmark for NF2. Using our in vitro human schwannoma model, we demonstrated that merlin-deficiency leads to increased proliferation, cell-matrix adhesion, and survival. Increased proliferation due to strong activation of extracellular-signal-regulated kinase 1/2 (ERK1/2) is caused by overexpression/activation …
Control Of Interneuron Dendritic Growth Through Nrg1/Erbb4-Mediated Kalirin-7 Disinhibition., M. E. Cahill, K. A. Jones, I. Rafalovich, Z. Xie, C. S. Barros, U. Müller, P. Penzes
Control Of Interneuron Dendritic Growth Through Nrg1/Erbb4-Mediated Kalirin-7 Disinhibition., M. E. Cahill, K. A. Jones, I. Rafalovich, Z. Xie, C. S. Barros, U. Müller, P. Penzes
Peninsula Medical School
Neuregulin 1 (NRG1) is a secreted trophic factor that activates the postsynaptic erbB4 receptor tyrosine kinase. Both NRG1 and erbB4 have been repeatedly associated with schizophrenia, but their downstream targets are not well characterized. ErbB4 is highly abundant in interneurons, and NRG1-mediated erbB4 activation has been shown to modulate interneuron function, but the role for NRG1-erbB4 signaling in regulating interneuron dendritic growth is not well understood. Here we show that NRG1/erbB4 promote the growth of dendrites in mature interneurons through kalirin, a major dendritic Rac1-GEF. Recent studies have shown associations of the KALRN gene with schizophrenia. Our data point to …
The Effects Of Manufactured Nanoparticles On Fish Physiology, Reproduction And Behaviour, Christopher Ramsden
The Effects Of Manufactured Nanoparticles On Fish Physiology, Reproduction And Behaviour, Christopher Ramsden
School of Biological and Marine Sciences Theses
Over the last decade the development and use of nanomaterials (NMs) and nanoparticles (NPs) has increased at a great rate. As a result there is an ever increasing risk of exposing humans and wildlife to these potentially harmful materials. Titanium dioxide nanoparticles (TiO2 NPs) and carbon nanotubes (CNTs) are two of the most widely used NMs at present. Their potentially harmful effects on organisms and physicochemical properties have been investigated in a growing number of scientific studies. However understanding the level of risk they may pose is far from satisfactory. The present body of work has addressed various aspects of …
Increased Water Current Induces Micro-Architectural Changes To The Vertebral Bone Of Juvenile Rainbow Trout (Oncorhynchus Mykiss), Mag Owen, B Eynon, S Woodgate, Sj Davies, S Fox
Increased Water Current Induces Micro-Architectural Changes To The Vertebral Bone Of Juvenile Rainbow Trout (Oncorhynchus Mykiss), Mag Owen, B Eynon, S Woodgate, Sj Davies, S Fox
School of Biomedical Sciences
No abstract provided.
Underweight And Overweight Men Have Greater Exercise-Induced Dyspnoea Than Normal Weight Men, Mmf Subhan, Sa Ali, Ssi Bokhari, Mn Khan, Hr Ahmad
Underweight And Overweight Men Have Greater Exercise-Induced Dyspnoea Than Normal Weight Men, Mmf Subhan, Sa Ali, Ssi Bokhari, Mn Khan, Hr Ahmad
School of Biomedical Sciences
No abstract provided.
Huntington's Disease And Its Therapeutic Target Genes: A Global Functional Profile Based On The Hd Research Crossroads Database, Ravi Kiran R. Kalathur, Miguel A. Hernández-Prieto, Matthias E. Futschik
Huntington's Disease And Its Therapeutic Target Genes: A Global Functional Profile Based On The Hd Research Crossroads Database, Ravi Kiran R. Kalathur, Miguel A. Hernández-Prieto, Matthias E. Futschik
School of Biomedical Sciences
Abstract Background Huntington’s disease (HD) is a fatal progressive neurodegenerative disorder caused by the expansion of the polyglutamine repeat region in the huntingtin gene. Although the disease is triggered by the mutation of a single gene, intensive research has linked numerous other genes to its pathogenesis. To obtain a systematic overview of these genes, which may serve as therapeutic targets, CHDI Foundation has recently established the HD Research Crossroads database. With currently over 800 cataloged genes, this web-based resource constitutes the most extensive curation of genes relevant to HD. It provides us with an unprecedented opportunity to survey molecular mechanisms …
Iron Deprivation In Synechocystis : Inference Of Pathways, Non-Coding Rnas, And Regulatory Elements From Comprehensive Expression Profiling, Miguel A. Hernández-Prieto, Verena Schön, Jens Georg, Luísa Barreira, João Varela, Wolfgang R. Hess, Matthias E. Futschik
Iron Deprivation In Synechocystis : Inference Of Pathways, Non-Coding Rnas, And Regulatory Elements From Comprehensive Expression Profiling, Miguel A. Hernández-Prieto, Verena Schön, Jens Georg, Luísa Barreira, João Varela, Wolfgang R. Hess, Matthias E. Futschik
School of Biomedical Sciences
Iron is an essential cofactor in many metabolic reactions. Mechanisms controlling iron homeostasis need to respond rapidly to changes in extracellular conditions, but they must also keep the concentration of intracellular iron under strict control to avoid the generation of damaging reactive oxygen species. Due to its role as a redox carrier in photosynthesis, the iron quota in cyanobacteria is about 10 times higher than in model enterobacteria. The molecular details of how such a high quota is regulated are obscure. Here we present experiments that shed light on the iron regulatory system in cyanobacteria. We measured time-resolved changes in …
Parental Care And The Development Of The Parent Offspring Conflict In Discus Fish (Symphysodon Spp.), Jonathan Buckley
Parental Care And The Development Of The Parent Offspring Conflict In Discus Fish (Symphysodon Spp.), Jonathan Buckley
School of Biological and Marine Sciences Theses
Parental care has evolved across the animal kingdom to increase the probability of offspring surviving in an environment fraught with danger. While parental care is common among mammals and birds, it is relatively rare in fish with the vast majority of fish showing no form of parental care at all, whilst those that do, often just provide parental care to developing eggs pre-hatch. The provision of parental care in discus fish (Symphysodon spp.) is, therefore, interesting in that parents provide mucus to offspring as a source of nutrition during the first few weeks of care. In mammals this post-birth provision …
Molecular Studies Of Karenia Mikimotoi (Dinophyceae) From The Celtic Sea Region, Manal A. Al-Kandari
Molecular Studies Of Karenia Mikimotoi (Dinophyceae) From The Celtic Sea Region, Manal A. Al-Kandari
School of Biological and Marine Sciences Theses
K. mikimotoi has been classified under many names and has been mis-assigned to different species and genera in the North Atlantic and Pacific because of its morphological similarities to other Gymnodinoid species. It is now known to be widely distributed, but there remain unresolved questions about whether K. mikimotoi was introduced into the North Sea from Japanese waters, or whether it has always inhabited this region and been erroneously classified as Gymnodinium spp. or has been a part of the hidden flora prior to be recognised in a bloom off the Norwegian coast in 1966. To address questions about geographical …
Iterative Orthology Prediction Uncovers New Mitochondrial Proteins And Identifies C12orf62 As The Human Ortholog Of Cox14, A Protein Involved In The Assembly Of Cytochrome C Oxidase, R Szklarczyk, Bfj Wanschers, Td Cuypers, Jj Esseling, Et Al
Iterative Orthology Prediction Uncovers New Mitochondrial Proteins And Identifies C12orf62 As The Human Ortholog Of Cox14, A Protein Involved In The Assembly Of Cytochrome C Oxidase, R Szklarczyk, Bfj Wanschers, Td Cuypers, Jj Esseling, Et Al
School of Biomedical Sciences
BACKGROUND: Orthology is a central tenet of comparative genomics and ortholog identification is instrumental to protein function prediction. Major advances have been made to determine orthology relations among a set of homologous proteins. However, they depend on the comparison of individual sequences and do not take into account divergent orthologs. RESULTS: We have developed an iterative orthology prediction method, Ortho-Profile, that uses reciprocal best hits at the level of sequence profiles to infer orthology. It increases ortholog detection by 20% compared to sequence-to-sequence comparisons. Ortho-Profile predicts 598 human orthologs of mitochondrial proteins from Saccharomyces cerevisiae and Schizosaccharomyces pombe with 94% …
Emergent Auditory Feature Tuning In A Real-Time Neuromorphic Vlsi System., Sadique Sheik, Martin Coath, Giacomo Indiveri, Susan L. Denham, Thomas Wennekers, Elisabetta Chicca
Emergent Auditory Feature Tuning In A Real-Time Neuromorphic Vlsi System., Sadique Sheik, Martin Coath, Giacomo Indiveri, Susan L. Denham, Thomas Wennekers, Elisabetta Chicca
School of Engineering, Computing and Mathematics
Many sounds of ecological importance, such as communication calls, are characterized by time-varying spectra. However, most neuromorphic auditory models to date have focused on distinguishing mainly static patterns, under the assumption that dynamic patterns can be learned as sequences of static ones. In contrast, the emergence of dynamic feature sensitivity through exposure to formative stimuli has been recently modeled in a network of spiking neurons based on the thalamo-cortical architecture. The proposed network models the effect of lateral and recurrent connections between cortical layers, distance-dependent axonal transmission delays, and learning in the form of Spike Timing Dependent Plasticity (STDP), which …