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Articles 5611 - 5640 of 6794
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Enrichment Of Minority Dna In Admixes Of Dna Samples:Potential Use In Non-Invasive Prenatal Diagnosis(Nipd), Of Down Syndrome, Tara Miran
Other Faculty of Science and Engineering Theses
Non-invasive prenatal diagnosis (NIPD) is a promising approach that is currently being developed. The principle is that fetal material can be detected in maternal plasma and potentially enable women to pursue reliable and timely prenatal diagnosis, whilst eliminating the risk of miscarriage associated with chorionic villus sampling or amniocentesis. However NIPD research has been restricted up until now for the diagnosis of Down syndrome due to the low concentration of free fetal DNA (ffDNA) in maternal plasma. Various methods have been developed in an attempt to increase the concentration of ffDNA. This study uses COLD-PCR (co-amplification at lower denaturation temperature …
Epidemiology And Public Health Significance Of Bovine Tuberculosis In Cattle In The Highlands Of Cameroon, Julius Awah Ndukum
Epidemiology And Public Health Significance Of Bovine Tuberculosis In Cattle In The Highlands Of Cameroon, Julius Awah Ndukum
Other Faculty of Science and Engineering Theses
Bovine tuberculosis (TB) is a contagious neglected zoonosis of cattle that is prevalent but under-investigated in Cameroon, hence this study was designed to assess the epidemiology of bovine TB in cattle, risks for M. bovis infection in cattle and humans; and public health implications of zoonotic bovine TB in the highlands of Cameroon. A retrospective study of meat inspection records (1994 – 2010) was done to estimate the prevalence of TB lesions in slaughtered cattle in the North West region. The prevalence of bovine TB and anti-bovine TB antibodies in live cattle based on tuberculin skin tests (2 surveys) and …
Biochemistry Of Antioxidants: Antioxidant Capacity Measurment Methods And Their Application To Develop Useful Indicators Of Stability And Functionality In Food Matrices, Kwestan Rafat Muhammad
Biochemistry Of Antioxidants: Antioxidant Capacity Measurment Methods And Their Application To Develop Useful Indicators Of Stability And Functionality In Food Matrices, Kwestan Rafat Muhammad
Other Faculty of Science and Engineering Theses
Abstract Antioxidant properties of green tea (GT) have been widely reported. The antioxidant capacity (AOC) of green tea was investigated to include the effect of infusion time over 24 hours. The AOC was measured by the FRAP, DPPH, TEAC, and CBA assays. It was proven according that after 2 hours of brewing, tea has higher AOC and Total phenolic content (TPC), these significantly decreases after 4 hours. GT has a high amount of polyphenols with potent AOC. However, interactions between polyphenols and food matrix may decrease their potential benefit. The objective of this experiment was to test the hypothesis that …
Biochemical, Metabolic And Morphological Responses Of The Intertidal Gastropod Littorina Littorea To Ocean Acidification And Increase Temperature, Sedercor Melatunan
Biochemical, Metabolic And Morphological Responses Of The Intertidal Gastropod Littorina Littorea To Ocean Acidification And Increase Temperature, Sedercor Melatunan
Other Faculty of Science and Engineering Theses
Future changes to the pH and temperature of the oceans are predicted to impact the biodiversity of marine ecosystems, particularly those animals that rely on the process of calcification. The marine intertidal gastropod Littorina littorea can be used as a model of intertidal organism for investigating the effects of ocean acidification and high temperature, alone and in combination because its ability to be quickly adapt against environmental stressor. In the first study a single species population of L. littorea was used to test for physiological and biochemical effects underpinning organismal responses to climate change and ocean acidification. Compared with control …
Sea Level Rise And Sustainability Of The Nigerian Coastal Zone, Olusola Olalekan Popoola
Sea Level Rise And Sustainability Of The Nigerian Coastal Zone, Olusola Olalekan Popoola
Other Faculty of Science and Engineering Theses
Globally, sea levels have risen in the last century, and various projections suggest substantial increases in sea level due to climate change in this century. In Nigeria, there are no up-to-date sea level rise (SLR) assessments for the coast. Much of the Nigerian coast is low lying with the consequence that a 1 to 3 metres rise in sea level, which may result from eustatic or climate change, will have a catastrophic effect on the human activities in these regions. This study examines the consequences of continued sea level rise with a focus on erosion and inundation for the Nigerian …
The Effect Of Phytoestrogens On Bone And T Cells Differentiation And Activity, Sahar Saadi Karieb
The Effect Of Phytoestrogens On Bone And T Cells Differentiation And Activity, Sahar Saadi Karieb
Other Faculty of Science and Engineering Theses
The fall in circulating oestrogen (E2) after the menopause leads to an increased rate of bone remodelling, excessive osteoclast activity and a greater fracture risk. Until recently hormone replacement therapy (HRT) was prescribed to post-menopausal women to prevent bone loss, however HRT is associated with an elevated incidence of cardiovascular disease, stroke and cancer. These side-effects led to an interest in naturally occurring compounds with oestrogenic action such as phytoestrogens (PEs), which are non-steroidal-plant derived compounds. Human trials and animal studies suggest a beneficial effect of PEs on bone mass, although their ability to modify osteoclast formation in response to …
Relations Between Impulsivity And Mindfulness In Adolescents With Behavioural, Emotional And Social Difficulties, Jessica Claire Bradford
Relations Between Impulsivity And Mindfulness In Adolescents With Behavioural, Emotional And Social Difficulties, Jessica Claire Bradford
Other Faculty of Science and Engineering Theses
Impulsivity and the effectiveness of a mindfulness-based intervention were explored in relation to improving behavioural self-regulation in adolescents with behavioural, emotional and social difficulties (BESD). A computerised choice task (CCT) was developed to measure delay discounting (a shift in choice from a larger reward to a smaller reward as the delay to the larger reward increases) in adolescents with BESD and compared it with several additional measures of impulsivity. The degree to which impulsivity and thoughts are related was explored using mindfulness measures. Effects of task type (computer versus sand-timer) and task context (school versus house) were also studied. Results …
Applications Of Spice Extracts And Other Hurdles To Improve Microbial Safety And Shelf- Life Of Cooked, High Fat Meat Products (Doner Kebab), Sahar Al-Kutby
Applications Of Spice Extracts And Other Hurdles To Improve Microbial Safety And Shelf- Life Of Cooked, High Fat Meat Products (Doner Kebab), Sahar Al-Kutby
Other Faculty of Science and Engineering Theses
There is a growing demand for safe and convenient meat products. The effect of natural spice extracts incorporated with other hurdles for controlling pathogenic bacteria and extending the shelf life of RTE doner kebab were investigated. A comprehensive literature review was undertaken to establish the status of microbial risk, use of additives, knowledge on oxidative deterioration and HACCP associated with meat products. The in vitro antioxidant and antibacterial activities of spice extracts were screened and compared. Cinnamon, clove, and sumac alcoholic extracts demonstrated strong antimicrobial effect, however, rosemary proved effective as antioxidant in a lamb fat model. An accelerated shelf …
Novel Particle Model For The Prediction Of Stability And Episodic Collapse Of Coastal Cliffs And Levees, Johan Richard Vandamme
Novel Particle Model For The Prediction Of Stability And Episodic Collapse Of Coastal Cliffs And Levees, Johan Richard Vandamme
Other Faculty of Science and Engineering Theses
This thesis investigates the WCSPH model by considering fluid entry and exit, and integrates the WCSPH method into a new, novel, particle-based Bluff Morphology Model (BMM). Using the BMM, this thesis investigates the stability, collapse and equilibrium position of soft coastal bluffs (cliffs). Fluid and floating object interaction using a novel adaptation of the WCSPH method is investigated by incorporating a floating object model. In particular, this thesis examines the water impact, hydrodynamic forces, fluid motions, and movement of objects in the conventional case studies of object entry and exit from still water. A two-dimensional wedge drop analysis was examined, …
Species Distribution Modelling To Support Marine Conservation Planning, Charlotte Emily Marshall
Species Distribution Modelling To Support Marine Conservation Planning, Charlotte Emily Marshall
Other Faculty of Science and Engineering Theses
This thesis explores some important practical considerations concerning the use of species distribution models in marine conservation planning. Using geo-referenced gorgonian distribution data, together with explanatory environmental variables, predictive models have been used to map the spatial distribution of suitable gorgonian (sea fan) habitat in two study sites; Hatton Bank, in the Northeast Atlantic, and Lyme Bay on the south coast of Devon. Generalized Linear Models (GLMs), Generalized Additive Models (GAMs) and a Maximum Entropy (Maxent) model have been used to support critical investigation into important model considerations that have received inadequate attention in the marine environment. The influence of …
Molecular Characterisation Of The Interaction Of Microbes With The Insulin Pathway, Raid Bahr Nisr
Molecular Characterisation Of The Interaction Of Microbes With The Insulin Pathway, Raid Bahr Nisr
Other Faculty of Science and Engineering Theses
Exposure to microorganisms is considered an environmental factor which can contribute to diabetes mellitus via cytotoxicity or autoimmune responses against pancreatic cells. Firstly, the effects on rat insulinoma pancreatic β-cell line of secondary metabolites pyrrolnitrin (Burkholderia spp), phenazine compounds (Pseudomonas aeruginosa and Burkholderia spp) were investigated. Both compounds separately showed significant cytotoxicity after 24 h and at concentrations of 10 & 100 ng/ml potentiated insulin gene transcription, Ca2+ content and glucose-stimulated insulin secretion (GSIS). Furthermore, the outward membrane current was inhibited by phenazine (100 ng/ml) or pyrrolnitrin (10 or 100 ng/ml). Secondly, the capacity of 45 microbial species to bind …
Mapping Deep-Sea Features In Uk Waters For Use In Marine Protected Area Network Design, Jaime Selina Davies
Mapping Deep-Sea Features In Uk Waters For Use In Marine Protected Area Network Design, Jaime Selina Davies
Other Faculty of Science and Engineering Theses
With an increase in demand on deep-sea resources comes a need for appropriate and effective management of this ecosystem. The establishment of a representative network of deep-sea Marine Protected Areas offers one tool with which to address the conservation needs of the deep sea. While a number of deep-sea habitats have been identified as vulnerable to anthropogenic activities (e.g. cold-water coral reefs and sponge aggregations), poor knowledge of the distribution of these habitats hinders conservation efforts and network planning, and thus we need habitat maps. With improvements in acoustic data resolution acquired from the deep sea, and the ability to …
Dietary Intake And Factors Affecting Vitamin D Status Of Middle Eastern People In The Uk, Wassan Abdel-Jaleel Ahmed
Dietary Intake And Factors Affecting Vitamin D Status Of Middle Eastern People In The Uk, Wassan Abdel-Jaleel Ahmed
Other Faculty of Science and Engineering Theses
Vitamin D is derived through the action of solar ultraviolet B radiation on skin and from a limited number of natural food sources, fortified foods and supplements. It is well known that vitamin D plays an active role for calcium and phosphorus absorption but there is also growing evidence of an association between vitamin D insufficiency and various chronic diseases. Middle Eastern populations are known to be at risk of vitamin D deficiency due to a diet low in vitamin D and low sunshine exposure. Obesity is also a risk factor since vitamin D is sequestered in body fat. This …
An Integrated Approach To Assess Impact Of Environmental Stress In Carp, Cyprinus Carpio L.: Biochemical, Genotoxic, Histopathological And Individual Level Effects, Sanaa A. Mustafa
Other Faculty of Science and Engineering Theses
Studies were undertaken to determine toxicological effects in a model species, Cyprinus carpio L. following hypoxic exposure either alone or in combination with representative heavy metal (i.e. copper; Cu) via a dietary route, at different levels of biological organisation (viz. biochemical, histological and individual level effects). Initially, the validation study of biological responses using a range of concentrations of dietary Cu as a relevant environmental contaminant was carried out (Chapter 3). The results showed a range of biological responses in exposed fish including significant genotoxic response as determined by induction of DNA strand breaks (i.e. the Comet assay) with bacterial …
Towards The Affect Of Intimacy, Juergen Moritz
Towards The Affect Of Intimacy, Juergen Moritz
Other Faculty of Arts, Humanities and Business Theses
Abstract This thesis explores the trajectory that the developing technological fields of Ambient Intelligence and Persuasive Technologies introduce new intricate relationships beyond fundamental use and availability because they change our abilities to act. Since its classic articulation by Hegel (1927) philosophical explication of the relationship between people and technology states that technology is a mediating factor between people and the world. Associated with this view, which has characterized the resulting phenomenology and philosophy of technology for nearly two decades, is an understanding of technology as a form of alienation. In this dissertation the author shows how this old interpretation of …
Life Expansion: Toward An Artistic, Design-Based Theory Of The Transhuman / Posthuman, Natasha Vita-More
Life Expansion: Toward An Artistic, Design-Based Theory Of The Transhuman / Posthuman, Natasha Vita-More
Other Faculty of Arts, Humanities and Business Theses
The thesis’ study of life expansion proposes a framework for artistic, design-based approaches concerned with prolonging human life and sustaining personal identity. To delineate the topic: life expansion means increasing the length of time a person is alive and diversifying the matter in which a person exists. For human life, the length of time is bounded by a single century and its matter is tied to biology. Life expansion is located in the domain of human enhancement, distinctly linked to technological interfaces with biology. The thesis identifies human-computer interaction and the potential of emerging and speculative technologies as seeding the …
Emergent Rhythmic Structures As Cultural Phenomena Driven By Social Pressure In A Society Of Artificial Agents, Joao Pedro Magalhaes Martins
Emergent Rhythmic Structures As Cultural Phenomena Driven By Social Pressure In A Society Of Artificial Agents, Joao Pedro Magalhaes Martins
Other Faculty of Arts, Humanities and Business Theses
This thesis studies rhythm from an evolutionary computation perspective. Rhythm is the most fundamental dimension of music and can be used as a ground to describe the evolution of music. More specifically, the main goal of the thesis is to investigate how complex rhythmic structures evolve, subject to the cultural transmission between individuals in a society. The study is developed by means of computer modelling and simulations informed by evolutionary computation and artificial life (A-Life). In this process, self-organisation plays a fundamental role. The evolutionary process is steered by the evaluation of rhythmic complexity and by the exposure to rhythmic …
Earhart County: The Making Of A World War Two Wondertale, Nicola Russell Johnson
Earhart County: The Making Of A World War Two Wondertale, Nicola Russell Johnson
Other Faculty of Arts, Humanities and Business Theses
The aim of Earhart County was to create a book which would bring the world of World War Two aviation to a mainstream audience, utilising the magic and durability of folklore to mythologize the incredible feats of Churchill’s finest generation. Whilst entertaining its audience, it aims at giving them a glimpse at the many lives and aircraft that flew during the war. Research was conducted mainly through the study of autobiographical and biographical accounts of both famous and unknown aircrew, as well as post-war and contemporary fiction, aircraft manuals and books detailing the various aeroplanes flown throughout the war. Research …
Ground: A Metaverse Learning Strategy For The Creative Fields, Elif Ayiter
Ground: A Metaverse Learning Strategy For The Creative Fields, Elif Ayiter
Other Faculty of Arts, Humanities and Business Theses
In this thesis I cover the theoretical framework and the practice based implications of bringing the fundamental principles of a cybernetic art educational strategy, the Groundcourse, which was developed and taught during the 1960’s in England by Roy Ascott, into the virtual, three dimensional builder’s world of the metaverse; to be implemented there as a non-institutional, voluntary, self-directed, adult oriented learning system for avatars – one which is expected to be taught by avatar instructors who will formulate the specifics of their curriculum and their methods based upon the cardinal tenets of the Groundcourse, which have been summarized by Roy …
Image And Evidence: The Study Of Attention Through The Combined Lenses Of Neuroscience And Art, Ellen K. Levy
Image And Evidence: The Study Of Attention Through The Combined Lenses Of Neuroscience And Art, Ellen K. Levy
Other Faculty of Arts, Humanities and Business Theses
This study proposed that new insights about attention, including its phenomenon and pathology, would be provided by combining perspectives of the neurobiological discourse about attention with analyses of artworks that exploit the constraints of the attentional system. To advance the central argument that art offers a training ground for the attentional system, a wide range of contemporary art was analysed in light of specific tasks invoked. The kinds of cognitive tasks these works initiate with respect to the attentional system have been particularly critical to this research. Attention was explored within the context of transdisciplinary art practices, varied circumstances of …
New Game Physics - Added Value For Transdisciplinary Teams, Andreas Schiffler
New Game Physics - Added Value For Transdisciplinary Teams, Andreas Schiffler
Other Faculty of Arts, Humanities and Business Theses
This study focused on game physics, an area of computer game design where physics is applied in interactive computer software. The purpose of the research was a fresh analysis of game physics in order to prove that its current usage is limited and requires advancement. The investigations presented in this dissertation establish constructive principles to advance game physics design. The main premise was that transdisciplinary approaches provide significant value. The resulting designs reflected combined goals of game developers, artists and physicists and provide novel ways to incorporate physics into games. The applicability and user impact of such new game physics …
The Value Of Marine Conservation, Sian Rees
The Value Of Marine Conservation, Sian Rees
Other Faculty of Science and Engineering Theses
The marine environment provides essential ecosystem services that are critical to the functioning of the earth’s life support system and the maintenance of human well-being. Marine Protected Areas (MPAs) are recognised as being the mechanism though which marine natural capital may be conserved. This thesis focuses on the value associated with marine conservation in a case study area, Lyme Bay, England where a ‘closed area’ was created in 2008. A review of literature spanning 20 years shows that despite sound ecological knowledge of a marine area, the reliance on traditional neo-classical economic valuations for marine spatial planning can obscure other …
The Evaluation Of Novel Bio-Ethanol Derived Co-Products As Potential Feed Ingredients For Carp Cyprinus Carpio And Tilapia Oreochromis Niloticus, Samd Sofy Omar
The Evaluation Of Novel Bio-Ethanol Derived Co-Products As Potential Feed Ingredients For Carp Cyprinus Carpio And Tilapia Oreochromis Niloticus, Samd Sofy Omar
Other Faculty of Science and Engineering Theses
The evaluation of novel Bio-ethanol derived co-products as potential feed ingredients for carp Cyprinus carpio and Tilapia Oreochromis nilitocus Samad S. Omar Abstract The nutritional value of novel yeast products were evaluated for warmwater fish species. A yeast co-product (yeast protein concentrate unrefined (YPCU)) obtained from a bio-ethanol process using wheat was tested using iso-nitrogenous (38% crude protein) and iso-lipidic (8%) diets for juvenile mirror carp (Cyprinus carpio). The fishmeal (FM) protein component of a basal diet was replaced by (YPCU) at 7.5, 15, 20, and 50% of total dietary protein. After an 8 week feeding trial, all fish fed …
Characterization Of Cholinesterase Activities For Pesticide Exposure In Food Animals, Kasim Sakran Abass Askar
Characterization Of Cholinesterase Activities For Pesticide Exposure In Food Animals, Kasim Sakran Abass Askar
Other Faculty of Science and Engineering Theses
The primary aim of the work described in this thesis is to establish a foundation for the applicability of a biochemical biomarker, cholinesterase (ChE) activity in food animal species, as an instrument for evaluating exposure to pollutants as well as predicting high-level effects on public health. Secondary aims are to increase the awareness of pesticide users of anti-ChE exposure, to decide whether poisoning episodes involve anti-ChE by measuring residual effects in tissues, and to identify sources of contamination in food animal tissues. The ChE are specialized carboxylic ester hydrolases that break down esters of choline. They are classified as either …
Non-Transferrin-Bound Iron And Protein Glycation In Type 2 Diabetes, Desley White
Non-Transferrin-Bound Iron And Protein Glycation In Type 2 Diabetes, Desley White
School of Health Professions Theses
Background and Methods The involvement of iron in the risk for, and complications of, type 2 diabetes has generated substantial interest over the past 15 years, initially sparked by an association with raised serum ferritin, and the observation that people with iron overload diseases frequently develop diabetes. Considerable advances have since been made in understanding the effect glucose has on molecules, cells, and tissues; and the role that oxidative stress plays in the development of the pathologies of long-term diabetes. Poorly liganded iron is potentially both a contributor to, and consequence of, these complications. In vitro experiments with glucose-incubated transferrin …
Integrated Biomarker And Molecular Responses In Marine Bivalve Following Exposure To Environmental Contaminants: Implications For Human And Environmental Health, Yanan Di
Other Faculty of Science and Engineering Theses
Environmental genotoxicants/carcinogens in the aquatic environment induce complex detrimental impacts on aquatic organisms. Integrated approach is required to comprehensively assess such impacts in terms of animal and environmental health. Biomarkers at different levels of biological organisations, including clearance rates (at individual level), histopathological alterations (at tissue level), DNA strand breaks using comet assay (at cellular level) and transcriptional alterations of key genes determined by real-time quantitative PCR (at molecular level), were designed and applied to analyse the impacts in marine bivalve: Mytilus sp., a classic bio-indicator species for environmental health monitoring, following exposure to selected environmental contaminants (i.e. Benzo(α)Pyrene (B(α)P), …
Landscape-Scale Population Dynamics: Field Observations And Modelling Of Puya Hamata, A Flagship Plant From The Andes, Paola M. García-Meneses
Landscape-Scale Population Dynamics: Field Observations And Modelling Of Puya Hamata, A Flagship Plant From The Andes, Paola M. García-Meneses
Other Faculty of Science and Engineering Theses
Important ecological processes happen over long periods of time and at the landscape scale. Effective conservation of biodiversity and management of natural resources and ecosystem services requires an understanding of these processes. Unfortunately, it is often impractical to conduct appropriate long-term, landscape-scale studies. Modelling offers an alternative approach. Complete ecosystems are too complex to model practically, but simulations of simplified systems provide useful insights of practical value. LandBaSE-P is an individual-based model for Puya hamata that provides information about impacts of fire on ecological processes in the páramo of the Reserva Ecológica El Ángel, Ecuador. Puya hamata is a flagship …
The Effects Of Lactobacillus Plantarum Ncimb 41607 On Salmonella Infection And The Microbial Population In The Gastrointestinal Tract Of The Chicken, Nabil Ali Wali
Other Faculty of Science and Engineering Theses
Salmonellosis is a foodborne disease, poultry and poultry products are the main source of the disease. Many countries including Iraq still use antibiotics to control Salmonella. The increase in antibiotic resistant bacteria putatively caused by the overuse of antibiotics in agriculture has provided the incentive to look for alterna-tives to antibiotic to control diseases in livestock. Lactic acid bacteria with probiotic characteristics have the potential to beneficially affect the gut microflora of chick-ens and help reduce the incidence of Salmonella infection. In this study, Lactobacillus plantarum NCIMB 41607 was examined in vitro for in-hibitory effects against Salmonella and in vivo …
Relating Genotoxicity To Dna Repair And Reproductive Success In Zebrafish (Danio Rerio) Exposed To Environmental Toxicants, Helena C. Reinardy
Relating Genotoxicity To Dna Repair And Reproductive Success In Zebrafish (Danio Rerio) Exposed To Environmental Toxicants, Helena C. Reinardy
Other Faculty of Science and Engineering Theses
The potential for environmental toxicants to cause genetic damage (genotoxicity) in organisms is a prominent concern because effects on DNA can compromise reproductive success and survival in organisms. Genotoxicity in male germ cells is of particular concern because damage to DNA in sperm may not be repaired and the consequences of damaged genetic material may be transgenerational (from parent to offspring). An integrated approach across multiple levels of biological organization is necessary to establish linkages between exposure to genotoxicants and subsequent effects at molecular and higher levels of biological organization. This thesis addresses the relation between toxicant-induced genotoxicity and reproductive …
Impacts Of Climate Change And Fisheries On The Celtic Sea Ecosystem, Valentina Lauria
Impacts Of Climate Change And Fisheries On The Celtic Sea Ecosystem, Valentina Lauria
Other Faculty of Science and Engineering Theses
Climate change and fisheries have affected marine environments worldwide leading to impacts on ecosystem structure and functioning. However there is clear evidence of spatial variability in the response of these impacts both within and among marine ecosystems. Although several studies have tried to explain the effect of these impacts on marine food webs, it is unclear how they interact, and how they may affect marine ecosystems remains an important unanswered question. This suggests the urgent need for multiple-trophic level and ecosystem-based management approaches to account for both fisheries and climate change impacts at ocean basins across the globe. Marine apex …