Digital Commons Network^™

Making The Case For Career Academies In Shaping Pre-Collegiate Students For Stem Career Pathways, Felix Quayson

Journal of Research in Technical Careers

Career academies are increasingly important in preparing pre-collegiate high school students for STEM pathways by connecting academic learning, technical skill development, career identity, and postsecondary readiness. STEM-focused career academies function as structured bridges between secondary education, higher education, and the labor market. Through small learning communities, interdisciplinary curricula, employer partnerships, work-based learning, and early exposure to college and career expectations, career academies help students understand STEM not only as school subjects but as possible futures. Research suggests that career academies can improve student engagement, support school persistence, and strengthen labor market outcomes when implemented with fidelity. The article concludes that …

Graduates Offered Chance To Teach, Study Through Fulbright Awards, Clara Turnage

University of Mississippi News

OXFORD, Miss. – The Fulbright U.S. Student Program has offered scholarships to seven University of Mississippi graduates to teach, study and conduct research across the globe.

Hmong Individuals Practicing Animism And Their Engagement With The Mental Health System, Bao Lee

Walden Dissertations and Doctoral Studies

No abstract provided.

Human Service Professionals’ Perspectives Of Family Reunification Programs, Tasha Tolbert

Walden Dissertations and Doctoral Studies

No abstract provided.

Exploring Biogeographical Ancestry Inference Of New York Residents Using A 45 Indel Panel, Amanda Martinez

Student Theses

Biogeographical ancestry (BGA) inference is an important tool in forensic science, providing supplemental information when comparison/reference DNA is not available for traditional DNA analyses. Insertion/deletion polymorphisms (INDELs) have been used in the last decade as ancestry-informative markers (AIMs) for BGA inference because they can be easily adapted to forensic-type samples and are determined using low cost and easy processing methods. Limited research has attempted to estimate ancestry and admixture in United States (U.S.) populations. This study evaluated the effectiveness of a 45- and 21- INDEL panel to measure population admixture proportions of four different origins (African, European, East Asian and …

Family Is Forever: A Qualitative Study Of The Impacts Of Adoption On Adoptees, Rebekah Mei Hedlund

Masters Theses

This study explores the lived experiences of adoptees and the ways in which adoption has impacted them. Grounded in communication theory of identity (CTI), this research examines how adoptees express their identities throughout their lives via communication. Using a qualitative approach, in-depth semi-structured interviews were conducted with adoptees over the age of 18 from diverse backgrounds. The findings revealed three key themes from adoptees: identity, education, and opportunity. Participants described identity to be an ongoing and evolving process throughout life, often influenced by biological origins and family dynamics.

The theme of education emerged through participants’ desire for educating potential adoptive …

Mitochondrial Ca2+ Uniporter (Mcu) Variants Form Plasma-Membrane Channels, Iuliia Polina, Jyotsna Mishra, Michael Cypress, Maria Landherr, Nedyalka Valkov, Isabel Chaput, Bridget Nieto, Brian Rhee, Ameneh Ahrari, Nathan Demichaelis, Kye-Im Jeon, Ulrike Mende, Peng Zhang, Bong Sook Jhun, Jin O-Uchi

Center for Translational Medicine Faculty Papers

MCU, originally known as CCDC109A, is widely recognized as the gene responsible for encoding a pore-forming subunit of a Ca2+-selective channel, mitochondrial Ca2+ uniporter complex (mtCUC). While MCU expression is typically highly mitochondrial-specific, we report here a protein variant derived from the MCU gene, termed MCU-S, which lacks the mitochondria-targeting sequence (MTS) and forms a Ca2+-permeable channel outside of mitochondria. The mRNA of MCU-S was ubiquitously expressed in all cell types/tissues tested, with particularly high expression in human platelets. MCU-S protein formed Ca2+ channels at the plasma membrane, which exhibited similar channel properties to those observed in mtCUC. MCU-S channels …

Impact Of Dissolved Organic Carbon And Temperature On Phytoplankton Biomass In An Outdoor Study, Ruaa Abass Lafta, Mohammed Hamdan

Baghdad Science Journal

Altered environmental conditions in aquatic ecosystems through Dissolved Organic Carbon (DOC) input and increased temperature influence phytoplankton communities. To assess the impacts of climate change as both single and combined effects of DOC inputs and temperature on phytoplankton growth, we conducted an outdoor experiment including four sets of conditions in triplicate: a) control, b) DOC treatment, c) temperature treatment, and d) DOC and temperature treatment. We added 10 mg/L of glucose (C₆H₁₂O₆) as a source of DOC. The warming treatment increased the water temperature by 3°C above the control (p-value < 0.05). The DOC treatment significantly affected pH, CO₂, and DOC …

Symmetrical Drug-Related Intertriginous And Flexural Exanthema Associated With Tirzepatide, William Goodman, Karan Pandher, Mahaa Ayub

Department of Dermatology and Cutaneous Biology Faculty Papers

No abstract provided.

Exploring The Perceptions Of Stigma Of Emotional Distress Among Black Clergy, Sharon S. Mccollough

Walden Dissertations and Doctoral Studies

No abstract provided.

Insights On The Origins And Repercussions Of Corruption In Haiti, Yves Louissaint

Walden Dissertations and Doctoral Studies

No abstract provided.

Determinants Of Pre-Exposure Prophylaxis Medication Use Among People Aged 18–29 Years Living In Florida, Jeremiah Magraubin Mchaka Wandabwa

Walden Dissertations and Doctoral Studies

No abstract provided.

Phkg2 Confers Resistance Of Escc To Cisplatin And Enhances Cxcl8-Dependent Immunosuppression To Exacerbate Tumorigenesis, Jiayan Wu, Chengrui Zhong, Haosheng Zheng, Fei Qin, Xianyu Qin, Yuzhen Zheng, Junguo Chen, Gengfeng Wang, Bozhu Jian, Zui Liu, Xingping Yang, Chao Cheng, Guolin Li, Hongying Liao

Faculty, Staff and Students Publications

Cisplatin (DDP)-based chemotherapy serves as a foundational cornerstone in the clinical management of esophageal squamous cell carcinoma (ESCC). However, intrinsic or acquired resistance to DDP persists as a significant clinical challenge, severely undermining therapeutic efficacy and contributing to unfavorable patient prognoses. Through functional screening with a CRISPR/Cas9 knockout library, transcriptomic profiling of cisplatin-resistant cell lines and clinical specimens, and in vitro/in vivo validation assays, we identified PHKG2 as a key mediator of cisplatin resistance in ESCC. Mechanistically, PHKG2-mediated cisplatin resistance is driven by the phosphorylation of IGF2BP3 at residues T225 and T306. This post-translational modification enhances IGF2BP3 phase separation, thereby …

Movement-Stabilized Three-Dimensional Optical Recordings Of Membrane Potential Changes And Calcium Dynamics In Hippocampal Ca1 Dendrites, Kevin C Gonzalez, Satoshi Terada, Asako Noguchi, George N Zakka, Cliodhna O'Toole, Giuliana Bilbao, Luke Reynolds, Anna Jász, Borbála Kertész, Zoltán Szadai, Alissa Shen, François St-Pierre, Franck Polleux, Attila Losonczy, Balázs Rózsa

Faculty, Staff and Students Publications

Local dendritic computations are thought to critically influence neuronal signaling and plasticity yet remain largely unexplored in vivo due to challenges in stably imaging small structures at ultrafast timescales. We developed a 3D real-time motion correction platform for movement-stabilized, ultrafast two-photon voltage imaging. By co-labeling CA1 pyramidal neurons with voltage and calcium indicators, we simultaneously measured somato-dendritic and electro-calcium coupling at multiple dendritic sites. We characterized isolated dendritic spikes and distance-dependent backpropagation of naturally occurring and photostimulation-evoked bursts and single spikes. We found that bursts backpropagated more reliably than single spikes, validated that somato-dendritic coupling decreases with distance from soma, …

Men Who Murder Their Families: Crime Script Analysis Of Surviving Familicide Perpetrators’ Characteristics And Behaviors, Margaret Potthoff

Walden Dissertations and Doctoral Studies

No abstract provided.

Childcare Center Administrators’ Challenges To Using Trauma-Informed Approaches With Children Experiencing Toxic Stress, Jessica Lynn Pierce

Walden Dissertations and Doctoral Studies

No abstract provided.

The Names We Carry, Christan Hickman

Masters Theses

The Names We Carry explores the weight of the labels and expectations we carry from others and sometimes from ourselves. It tells the story of moving from exhaustion, self-doubt, and trying to be everything for everyone to discovering rest, boundaries, and a sense of wholeness. The book looks at identities people have given us and asks whether these names show who we really are or who we had to become to survive. It is about learning to live fully, care for ourselves without guilt, and embrace authenticity in work, relationships, and faith. At its heart, The Names We Carry is …

Dialogue In Screenwriting: Developing The Character Through Conversation, Madalynn Ruth Shiderly

Masters Theses

The purpose of this document is to highlight the importance of dialogue in a screenplay, discuss specific examples of dialogue from well-known films, and analyze how words affect the characterization of a film’s protagonist. First, the document explains the importance of having strong characters in a story for it to be compelling enough for audiences to engage with it. Then, the question of whether character or plot is more important in a narrative is discussed. Finally, the document introduces the concept of dialogue in a screenplay, forming the argument that dialogue is just as important as plot structure. For this …

The Message Within The Show: A Cultivation Study On The Impact Of Children's Television On Perceptions Of The Family, Ashley Bowes Fletcher

Masters Theses

The purpose of this qualitative research study was to explore the impacts of popular early 2000s children’s television shows on now-adult viewers’ perceptions of the nuclear family. The problem is that current scholarly literature had not addressed how early 2000s television shows have impacted the perception of a traditional nuclear family’s role in society. This study sought to identify the views currently held by the participants regarding the importance and roles of the nuclear family. The study also sought to identify the participant’s perceptions of the portrayals of the nuclear family in specific early 2000s children’s sitcoms. Through a variety …

Adam, The First Scientist: Unlocking The True Foundation Of Scientific Thinking, Thomas E. Lohman Jr.

Masters Theses

This thesis investigates the complex relationship between scientific thought and theological perspectives, proposing that God breathing life into Adam symbolizes a full divine inspiration for both scientific and theological understanding. The perceived conflict between science and theology arises from a shift in human thinking at the fall, which altered humanity's ability to rightly grasp both realms. After this crucial event, science shifted to a more naturalistic approach, while theology often downplayed God's sovereign power over creation.

The alterations to the original functions and purposes of science and theology have led to a fragile relationship between the two. According to Scripture, …

Dialogue Between Mind And Algorithm: Deep Symbiosis Of Psychology And Artificial Intelligence, Xiaolan Fu, Zheng Yan

Bulletin of Chinese Academy of Sciences (Chinese Version)

As artificial intelligence (AI) evolves from a supportive tool into a collaborative partner, the convergence of psychology and AI is gradually shifting from one-way application toward deep symbiosis. This study discusses the mutual empowerment resulting from their interaction, as well as the challenges they face and potential pathways to breakthroughs. On the one hand, psychology empowers AI by enhancing its human-like intelligence and social adaptability through cognitive modeling and ethical constraints; on the other hand, AI empowers psychology by leveraging multimodal data and algorithmic models to revolutionize psychological assessment and intervention methods. This deep symbiosis requires a clear-eyed acknowledgment of …

Crystal Structure Of Mouse Dxo In Complex With The Udp-N-Acetylglucosamine Cap And Molecular Mechanism For The Decapping Reactions, Najeeb Ullah, Selom K. Doamekpor, Liang Tong

Department of Biochemistry and Molecular Biology Faculty Papers

Noncanonical metabolite 5' caps have recently been identified on RNAs, and the DXO/Rai1 family of enzymes can remove these caps in eukaryotes. While the binding modes of NAD, FAD and dephospho-CoA (dpCoA) caps in the active site of mouse DXO have been determined, how DXO recognizes the UDP-glucose (UDP-Glc) and UDP-N-acetylglucosamine (UDP-GlcNAc) caps is not known. In addition, the molecular mechanism by which DXO catalyzes the decapping reactions is still poorly understood, especially the location of the water/hydroxide that attacks the scissile phosphate to initiate the decapping. Here we report the crystal structure of mouse DXO in complex with UDP-GlcNAc …

Arylation Of Nitrogen, Oxygen And Carbon Nucleophiles By Aryl(Tmp)Iodonium Salts, Joseph Jordan Hatton

Dissertations and Theses

Substituted aromatic rings are present in industry in a plethora of organic molecules such as pharmaceuticals, agrochemicals, materials and beyond. Therefore, methods for broadly installing aryl rings into other compounds to create substituted aromatic rings are valuable to many organic chemists. Historically these transformations are achieved through methods such as nucleophilic aromatic substitution and metal catalyzed cross-coupling. Nucleophilic aromatic substitution is a user-friendly method in this space but is limited by reliance on specific electronics. Metal catalyzed cross-coupling reduced the dependence on electronics in this space, but metals are generally unattractive reagents due to high costs, toxicity and challenges with …

Heat Shock Factor 1 Signaling: A Novel Pathway Implicated In Rett Syndrome Pathophysiology, Sonia Gonzalez

Dissertations

Rett syndrome (RTT) is a severe neurodevelopmental disorder that is associated with loss-of-function mutations in the methyl-CPG binding protein 2 (MECP2) gene. There are limited therapeutic options to address the wide range of social, cognitive, motor, and respiratory symptoms that patients experience throughout their lifetime. To identify novel therapeutic targets, we leveraged a rare form of RTT known as MeCP2-mutation-negative or atypical RTT. Traditionally, RTT is first diagnosed clinically and then confirmed through the identification of mutations in the MECP2 gene. However, ~5% of RTT patients are found to be MeCP2-mutation-negative (atypical), despite sharing overlapping symptomology with typical RTT. We …

Brain-Wide Structural Markers Of Familial And Clinical Risk For Bipolar Disorder In Youth, Danella M Hafeman, Jamie Feldman, John Merranko, Mary L Phillips, Boris Birmaher, Si Gao, Yizhou Ma, Peter Kochunov

Faculty, Staff and Student Publications

Background: Bipolar Disorder (BD) is a severe mental illness, often emerging during adolescence, that is associated with significant psychosocial impairment. BD risk is elevated in offspring of affected parents, particularly those with antecedent symptoms (e.g., mood lability, subthreshold manic symptoms). However, robust, replicable brain-based markers of risk in this population are lacking. We assessed the degree to which the Regional Vulnerability Index for BD (RVI-BD), quantified as an individual's brain-wide similarity to BD patterns derived from meta-analytic studies, is elevated in youth at familial risk and correlates with symptom predictors of BD.

Methods: We recruited n=82 adolescents (10-15 years old), …

“We Are Physically Alive But Mentally Dead”: The International Community Must Take Action To Ensure Women’S Right To Education In Afghanistan, Solveig J. Clifford

BYU Law Review

International treaties recognize the right to education as a fundamental human right. The Taliban, which currently act as the government as Afghanistan, are legally bound by treaty obligations to respect the right to education. The Taliban have banned women and girls from receiving education past the sixth grade, which is illegal under international law. During the Taliban’s previous regime in Afghanistan, they implemented a similar policy, which had disastrous results for an entire generation of Afghan women. Once again, the education ban is causing severe harm to the women and girls of Afghanistan. The international community has failed to take …

The Implications Of Well-Being On Job Retention: An Exploration Of Organizational Outcomes In Elementary Education, Courtney Winters

Doctoral Dissertations and Projects

Many organizations continue to face a rapidly declining workforce within the field of education. Organizational factors such as leadership or communication style can have |drastic effects on educators’ well-being, which is also linked to long-term organizational commitment. This mixed-methods study explored the role of organizational factors on employee well-being and retention in the elementary educational arena. In conducting semi-structured interviews, ten participants who held various roles within a school campus were included in this study, focusing on their lived experiences. In addition to informational interviews, a final, post-interview survey question was incorporated to provide a holistic approach in investigating the …

The Role Of Faith In Coping With Mental Health Challenges In Late Life: A Phenomenological Study Of Religious Experience In The Aging Population, Krista Kelley

Doctoral Dissertations and Projects

Depression, anxiety, and suicidal ideation are significant concerns among older adults. These conditions are often neglected due to stigma, atypical symptom presentation, and medical comorbidities, resulting in increased healthcare utilization, heightened suicide risk, and emotional dysregulation. Psychosocially, these challenges obstruct a successful resolution of Erikson’s final stage, ego integrity versus despair, leading to dissatisfaction, regret, and reduced well-being. Although previous research has suggested a link between religious engagement and improved mental health outcomes, few studies have explored older adults’ lived experiences of faith in coping with mental health. This qualitative phenomenological study examined the experiences of 25 older adults regarding …

Examining The Relationship Between Dark Triad Personality Traits And Career Paths, Mary Robinson Gibson

Doctoral Dissertations and Projects

Growing opportunities in information technology, digital accounting, and remote leadership have increased interest in the personality traits associated with these emerging work environments. The researcher examined the relationship between psychopathy, narcissism, and Machiavellianism, collectively referred to as Dark Triad personality traits, and career preferences. Specifically, the researcher tested whether higher levels of these traits predicted interest in careers characterized by prestige, power, autonomy, and opportunities for manipulation. Working professionals and college students completed the Short Dark Triad (SD3) and a career preference questionnaire. The researcher used binary logistic regression to assess whether Dark Triad traits predicted career cluster selection. Model …

Winning Formula: The Life Of Colonel Edward R. Bradley, Lorraine Potter

Doctoral Dissertations and Projects

Edward R. Bradley was a towering cultural icon of the early twentieth century. He is best known as the owner and breeder of four Kentucky Derby winning horses and as the owner and operator of the longest-running illegal casino in American history. However, Bradley's story has rarely been told, due to both his characteristic humility and the dubious nature of his profession. Bradley worked, lived, and invested in nearly every pivotal American region during the Progressive Era, plying his trade as a highly successful gambler, speculator, and horse breeder. Though his accomplishments were immense, his demeanor remained dignified, plainspoken, and …