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Articles 2251 - 2280 of 10900
Full-Text Articles in Entire DC Network
Outcome Evaluation Of Active Herts: A Community-Based Physical Activity Programme For Inactive Adults At Risk Of Cardiovascular Disease And/Or Low Mental Wellbeing, Angel M. Chater, Joerg Schulz, Andy Jones, Amanda Burke, Shelby Carr, Dora Kukucska, Nick Troop, Daksha Trivedi, Neil Howlett
Outcome Evaluation Of Active Herts: A Community-Based Physical Activity Programme For Inactive Adults At Risk Of Cardiovascular Disease And/Or Low Mental Wellbeing, Angel M. Chater, Joerg Schulz, Andy Jones, Amanda Burke, Shelby Carr, Dora Kukucska, Nick Troop, Daksha Trivedi, Neil Howlett
School of Psychology
BackgroundA high proportion of UK adults are inactive, which can lead to a range of physical and mental health concerns. Active Herts is a community-based physical activity programme for inactive adults at risk of cardiovascular disease and/or low mental wellbeing. This paper provides a pragmatic evaluation of this programme.MethodThis longitudinal study observed 717 adults (68% female, mean age = 56.9 years) from the “Active Herts” programme. Programme users were provided with a 45-min consultation with a “Get Active Specialist,” who talked them through an Active Herts self-help booklet and then signposted them to free or subsidized local exercise sessions. Programme …
Wave Interaction And Energy Absorption From Arrays Of Complex-Shaped Point Absorbers, Y Liu, S Zheng, H Liang, P Cong
Wave Interaction And Energy Absorption From Arrays Of Complex-Shaped Point Absorbers, Y Liu, S Zheng, H Liang, P Cong
School of Engineering, Computing and Mathematics
Water wave interactions with arrays of wave energy converters are numerically investigated based on the interaction theory. The converter is a heaving point absorber that can harness the ocean wave energy through up-and-down movements. A semi-analytical hybrid method is developed that combines the boundary element method and the interaction theory. The developed numerical method is verified against theoretical solutions for arrays of truncated vertical circular cylinders. Three different array layouts are studied in detail. It is found that trapped waves exist at critical wave numbers just below the cutoff values, and the peak load on the middle device increases with …
Timely Intervention, Monitoring And Education Matters In Ms (Time Matters In Ms): Development Of A Globally Applicable Quality Improvement Tool, Jeremy Hobart, Helmut Butzkueven, Jodi Haartsen, Tjalf Ziemssen, Thirusha Lane, Gavin Giovannoni
Timely Intervention, Monitoring And Education Matters In Ms (Time Matters In Ms): Development Of A Globally Applicable Quality Improvement Tool, Jeremy Hobart, Helmut Butzkueven, Jodi Haartsen, Tjalf Ziemssen, Thirusha Lane, Gavin Giovannoni
Peninsula Medical School
Background Previously, consensus MS care standards were defined by MS specialist neurologists from 19 countries. We developed, piloted and refined an Excel-based quality improvement tool to enable MS services to benchmark against these standards. Here, we examine the refined tool. Objective To determine the applicability of the quality improvement tool in different healthcare settings. Methods MS centres across the globe were invited to pilot the quality improvement tool by coding the medical records of 36 adults with MS. We invited feedback on user friendliness, quality improvement tool usefulness and relevance of data collected. Results Seventeen centres from 14 countries participated; …
The Unexceptional Im/Mobilities Of Gender-Based Violence In The Covid-19 Pandemic, Lesley Murray, Amanda Holt, Sian Lewis, Jessica Moriarty
The Unexceptional Im/Mobilities Of Gender-Based Violence In The Covid-19 Pandemic, Lesley Murray, Amanda Holt, Sian Lewis, Jessica Moriarty
School of Law, Humanities and Social Sciences
No abstract provided.
Editorial, A Syska
Editorial, A Syska
School of Law, Humanities and Social Sciences
No abstract provided.
Escalation Of Care In Children At High Risk Of Clinical Deterioration In A Tertiary Care Children’S Hospital Using The Bedside Pediatric Early Warning System, Orsola Gawronski, Jos Maria Latour, Corrado Cecchetti, A Lula, Lucilla Ravà, Degli Atti Ml Ciofi, Immacolata Dall’Oglio, Emanuela Tiozzo, Massimiliano Raponi, Christopher S. Parshuram
Escalation Of Care In Children At High Risk Of Clinical Deterioration In A Tertiary Care Children’S Hospital Using The Bedside Pediatric Early Warning System, Orsola Gawronski, Jos Maria Latour, Corrado Cecchetti, A Lula, Lucilla Ravà, Degli Atti Ml Ciofi, Immacolata Dall’Oglio, Emanuela Tiozzo, Massimiliano Raponi, Christopher S. Parshuram
School of Nursing and Midwifery
Abstract Background Escalation and de-escalation are a routine part of high-quality care that should be matched with clinical needs. The aim of this study was to describe escalation of care in relation to the occurrence and timing of Pediatric Intensive Care Unit (PICU) admission in a cohort of pediatric inpatients with acute worsening of their clinical condition. Methods A monocentric, observational cohort study was performed from January to December 2018. Eligible patients were children: 1) admitted to one of the inpatient wards other than ICU; 2) under the age of 18 years at the time of admission; 3) with two …
Germline Homozygous Missense Depdc5 Variants Cause Severe Refractory Early-Onset Epilepsy, Macrocephaly And Bilateral Polymicrogyria, A Ververi, S Zagaglia, Sm Sisodiya, Ja Hurst, Et Al
Germline Homozygous Missense Depdc5 Variants Cause Severe Refractory Early-Onset Epilepsy, Macrocephaly And Bilateral Polymicrogyria, A Ververi, S Zagaglia, Sm Sisodiya, Ja Hurst, Et Al
Peninsula Medical School
DEPDC5 (DEP Domain-Containing Protein 5) encodes an inhibitory component of the mammalian target of rapamycin (mTOR) pathway and is commonly implicated in sporadic and familial focal epilepsies, both non-lesional and in association with focal cortical dysplasia. Germline pathogenic variants are typically heterozygous and inactivating. We describe a novel phenotype caused by germline biallelic missense variants in DEPDC5. Cases were identified clinically. Available records, including magnetic resonance imaging and electroencephalography, were reviewed. Genetic testing was performed by whole exome and whole-genome sequencing and cascade screening. In addition, immunohistochemistry was performed on skin biopsy. The phenotype was identified in nine children, eight …
Germline Homozygous Missense Depdc5 Variants Cause Severe Refractory Early-Onset Epilepsy, Macrocephaly And Bilateral Polymicrogyria, Athina Ververi, Sara Zagaglia, Lara Menzies, Julia Baptista, Richard Caswell, Stephanie Baulac, Sian Ellard, Sally Lynch, Thomas S. Jacques, Maninder Singh Chawla, Martin Heier, Mari Ann Kulseth, Inger Lise Mero, Anne Katrine Våtevik, Ichraf Kraoua, Rhouma H Ben, Younes T Ben, Zouhour Miladi, Youssef Turki I Ben, Wendy D. Jones, Emma Clement, Christin Eltze, Kshitij Mankad, Ashirwad Merve, Jennifer Parker, Bethan Hoskins, Ronit Pressler, Sniya Sudhakar, Catherine Devile, Catherine Devile, Marios Kaliakatsos, Robert Robinson, Sara Margrete Bøen Keim, Imen Habibi, Alexandre Reymond, Sanjay M. Sisodiya, Jane A. Hurst
Germline Homozygous Missense Depdc5 Variants Cause Severe Refractory Early-Onset Epilepsy, Macrocephaly And Bilateral Polymicrogyria, Athina Ververi, Sara Zagaglia, Lara Menzies, Julia Baptista, Richard Caswell, Stephanie Baulac, Sian Ellard, Sally Lynch, Thomas S. Jacques, Maninder Singh Chawla, Martin Heier, Mari Ann Kulseth, Inger Lise Mero, Anne Katrine Våtevik, Ichraf Kraoua, Rhouma H Ben, Younes T Ben, Zouhour Miladi, Youssef Turki I Ben, Wendy D. Jones, Emma Clement, Christin Eltze, Kshitij Mankad, Ashirwad Merve, Jennifer Parker, Bethan Hoskins, Ronit Pressler, Sniya Sudhakar, Catherine Devile, Catherine Devile, Marios Kaliakatsos, Robert Robinson, Sara Margrete Bøen Keim, Imen Habibi, Alexandre Reymond, Sanjay M. Sisodiya, Jane A. Hurst
Peninsula Medical School
Abstract DEPDC5 (DEP Domain-Containing Protein 5) encodes an inhibitory component of the mammalian target of rapamycin (mTOR) pathway and is commonly implicated in sporadic and familial focal epilepsies, both non-lesional and in association with focal cortical dysplasia. Germline pathogenic variants are typically heterozygous and inactivating. We describe a novel phenotype caused by germline biallelic missense variants in DEPDC5. Cases were identified clinically. Available records, including magnetic resonance imaging and electroencephalography, were reviewed. Genetic testing was performed by whole exome and whole-genome sequencing and cascade screening. In addition, immunohistochemistry was performed on skin biopsy. The phenotype was identified in nine children, …
An Audit Of Sharps Injuries In Clinical Skills Simulation Wards At A Uk University, Kevin Hambridge, Ruth Endacott, Andrew Nichols
An Audit Of Sharps Injuries In Clinical Skills Simulation Wards At A Uk University, Kevin Hambridge, Ruth Endacott, Andrew Nichols
School of Nursing and Midwifery
Background/Aims Healthcare students are at high risk of sharps injuries, which can negatively impact their confidence and wellbeing. This study audited three clinical skills simulation wards at a UK university to determine the incidence of sharps injuries in this educational setting. Methods An audit of sharps injuries sustained in three clinical skills simulation wards was conducted, including data from 2008–2016. The authors developed an audit tool to collect data on the number of incidents that occurred, the type of individual involved and the nature of the incident. Results were analysed to compare the incidence of general injuries and sharps injuries …
‘Pushing Back’: People Newly Diagnosed With Dementia And Their Experiences Of The Covid‐19 Pandemic Restrictions In England, J Dixon, B Hicks, K Gridley, R Perach, Et Al
‘Pushing Back’: People Newly Diagnosed With Dementia And Their Experiences Of The Covid‐19 Pandemic Restrictions In England, J Dixon, B Hicks, K Gridley, R Perach, Et Al
Peninsula Medical School
Background and Objectives Research into people with dementia's experiences of the Covid-19 pandemic has tended to focus on vulnerabilities and negative outcomes, with the risk of reproducing a discourse in which people with dementia are positioned as passive. Informed by concepts positioning people with dementia as ‘active social agents’, we aimed to identify the pandemic-related challenges faced by people recently diagnosed with dementia and examine the ways in which they actively coped with, and adapted to, these challenges. Research Design and Methods In-depth interviews with 21 people recently diagnosed with dementia, recruited through an existing national cohort. Data was analysed …
Rapid Exome Sequencing In Critically Ill Children Impacts Acute And Long-Term Management Of Patients And Their Families: A Retrospective Regional Evaluation, Jdc Pereira Baptista
Rapid Exome Sequencing In Critically Ill Children Impacts Acute And Long-Term Management Of Patients And Their Families: A Retrospective Regional Evaluation, Jdc Pereira Baptista
Peninsula Medical School
INTRODUCTION: Genetic disorders are a significant cause of paediatric morbidity and mortality. Rapid exome sequencing was introduced by the National Health Service (NHS) in England on 1st October 2019 for acutely unwell children with a likely monogenic disorder, or to inform current pregnancy management where there was a previously affected child or fetus. We present results of a 12-month patient cohort from one large clinical genetics centre in England. METHODS: Patients were identified through local genetics laboratory records. We included all cases which underwent rapid exome sequencing between 1st October 2020 and 30th September 2021. DNA was extracted, quality checked …
Long Nineteenth Century Ephemera, J Gregory
Long Nineteenth Century Ephemera, J Gregory
School of Law, Humanities and Social Sciences
No abstract provided.
Bi-Allelic Letm1 Variants Perturb Mitochondrial Ion Homeostasis Leading To A Clinical Spectrum With Predominant Nervous System Involvement, Jdc Pereira Baptista
Bi-Allelic Letm1 Variants Perturb Mitochondrial Ion Homeostasis Leading To A Clinical Spectrum With Predominant Nervous System Involvement, Jdc Pereira Baptista
Peninsula Medical School
Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) encodes an inner mitochondrial membrane protein with an osmoregulatory function controlling mitochondrial volume and ion homeostasis. The putative association of LETM1 with a human disease was initially suggested in Wolf-Hirschhorn syndrome, a disorder that results from de novo monoallelic deletion of chromosome 4p16.3, a region encompassing LETM1. Utilizing exome sequencing and international gene-matching efforts, we have identified 18 affected individuals from 11 unrelated families harboring ultra-rare bi-allelic missense and loss-of-function LETM1 variants and clinical presentations highly suggestive of mitochondrial disease. These manifested as a spectrum of predominantly infantile-onset (14/18, 78%) and variably progressive …
Pharmacogenomics: An Opportunity For Personalised Psychotropic Prescribing In Adults With Intellectual Disabilities, B Perera, C Steward, K Courtenay, T Andrews, R Shankar
Pharmacogenomics: An Opportunity For Personalised Psychotropic Prescribing In Adults With Intellectual Disabilities, B Perera, C Steward, K Courtenay, T Andrews, R Shankar
Peninsula Medical School
There is growing evidence for the use of pharmacogenomics in psychotropic prescribing. People with intellectual disabilities are disproportionately prescribed psychotropics and are at risk of polypharmacy. There is an urgent need for safeguards to prevent psychotropic overprescribing but it is equally crucial that this population is not left behind in such exciting initiatives. Understanding how genetic variations affect medications is a step towards personalised medicine. This may improve personalised prescribing for people with intellectual disabilities, especially given the high rate of psychiatric and behavioural problems in this population. Our editorial explores opportunities and challenges that pharmacogenomics offers for the challenges …
Cataract, Abnormal Electroretinogram And Visual Evoked Potentials In A Child With Sma-Led2 - Extending The Phenotype, Agata Oliwa, Shuko Joseph, Eoghan Millar, Iain Horrocks, Dawn Penman, Julia Baptista, Thomas Cullup, Panayiotis Constantinou, Anne Marie Heuchan, Ruth Hamilton, Cheryl Longman
Cataract, Abnormal Electroretinogram And Visual Evoked Potentials In A Child With Sma-Led2 - Extending The Phenotype, Agata Oliwa, Shuko Joseph, Eoghan Millar, Iain Horrocks, Dawn Penman, Julia Baptista, Thomas Cullup, Panayiotis Constantinou, Anne Marie Heuchan, Ruth Hamilton, Cheryl Longman
Peninsula Medical School
This case report describes a girl who presented antenatal arthrogryposis and postnatal hypotonia, generalized and respiratory weakness, joint deformities particularly affecting the lower limbs and poor swallow. By 5 months, cataracts, abnormal electroretinograms, visual evoked potentials and global developmental impairments were recognized. No causative variants were identified on targeted gene panels. After her unexpected death at 11 months, gene-agnostic trio whole exome sequencing revealed a likely pathogenic de novo BICD2 missense variant, NM_001003800.1, c.593T>C, p.(Leu198Pro), confirming the diagnosis of spinal muscular atrophy lower extremity predominant type 2 (SMA-LED2). We propose that cataracts and abnormal electroretinograms are novel features of …
Mobile Health As A Primary Mode Of Intervention For Women At Risk Of, Or Diagnosed With, Gestational Diabetes Mellitus, Katie J. Edwards, Kate Maslin, Jackie Andrade, Ray B. Jones, Jill Shawe
Mobile Health As A Primary Mode Of Intervention For Women At Risk Of, Or Diagnosed With, Gestational Diabetes Mellitus, Katie J. Edwards, Kate Maslin, Jackie Andrade, Ray B. Jones, Jill Shawe
School of Nursing and Midwifery
Objective: The objective of this review was to map the knowledge related to the use of mobile health (mHealth) as a primary mode of intervention for the prevention and management of gestational diabetes mellitus and its long-term implications among women at risk of or diagnosed with gestational diabetes mellitus. We also sought to understand if mHealth for women at risk of or diagnosed with gestational diabetes mellitus incorporated relevant behavior change theory and techniques.Introduction: Prevention and management of gestational diabetes mellitus and its associated adverse outcomes are important to maternal and infant health. Women with gestational diabetes mellitus report high …
Linking Variation In Planktonic Primary Production To Coral Reef Fish Growth And Condition, Rc Roche, A Heenan, Bm Taylor, Jn Schwarz, Et Al
Linking Variation In Planktonic Primary Production To Coral Reef Fish Growth And Condition, Rc Roche, A Heenan, Bm Taylor, Jn Schwarz, Et Al
School of Biological and Marine Sciences
Within low-nutrient tropical oceans, islands and atolls with higher primary production support higher fish biomass and reef organism abundance. External energy subsidies can be delivered onto reefs via a range of physical mechanisms. However, the influence of spatial variation in primary production on reef fish growth and condition is largely unknown. It is not yet clear how energy subsidies interact with reef depth and slope. Here we test the hypothesis that with increased proximity to deep-water oceanic nutrient sources, or at sites with shallower reef slopes, parameters of fish growth and condition will be higher. Contrary to expectations, we found …
Exploring Support Strategies For Improving Nursing Student Retention, Danielle Edge, Nicholas Gladstone
Exploring Support Strategies For Improving Nursing Student Retention, Danielle Edge, Nicholas Gladstone
School of Nursing and Midwifery
Nursing student attrition is a significant concern in many countries, including the UK. Higher education institutions (HEIs) are seeking creative ways of improving retention and it is crucial to understand which support strategies encourage students to persist with their studies. This article describes a systematic review of the literature exploring nursing students' experiences and perceptions of support strategies used by HEIs to reduce attrition and improve retention. Having a sense of belonging, a connection with the university, self-confidence, self-efficacy and motivation appeared to make students more likely to stay on their course. Several support strategies appeared to enhance retention, including …
Evaluating The Effectiveness Of Text Pre-Processing In Sentiment Analysis, Ma Palomino, F Aider
Evaluating The Effectiveness Of Text Pre-Processing In Sentiment Analysis, Ma Palomino, F Aider
School of Engineering, Computing and Mathematics
Practical demands and academic challenges have both contributed to making sentiment analysis a thriving area of research. Given that a great deal of sentiment analysis work is performed on social media communications, where text frequently ignores the rules of grammar and spelling, pre-processing techniques are required to clean the data. Pre-processing is also required to normalise the text before undertaking the analysis, as social media is inundated with abbreviations, emoticons, emojis, truncated sentences, and slang. While pre-processing has been widely discussed in the literature, and it is considered indispensable, recommendations for best practice have not been conclusive. Thus, we have …
Navigating Uncertain Illness Trajectories For Young Children With Serious Infectious Illness: A Modified Grounded Theory Study., Sarah Neill, Lucy Bray, Bernie Carter, Damian Roland, Enitan D. Carrol, Lucie Riches, Joanne Hughes, Poornima Pandey, J O'Donnell, Sue Palmer-Hill, Natasha Bayes
Navigating Uncertain Illness Trajectories For Young Children With Serious Infectious Illness: A Modified Grounded Theory Study., Sarah Neill, Lucy Bray, Bernie Carter, Damian Roland, Enitan D. Carrol, Lucie Riches, Joanne Hughes, Poornima Pandey, J O'Donnell, Sue Palmer-Hill, Natasha Bayes
School of Nursing and Midwifery
Background Infectious illness is the biggest cause of death in children due to a physical illness, particularly in children under five years. If mortality is to be reduced for this group of children, it is important to understand factors affecting their pathways to hospital. The aim of this study was to retrospectively identify organisational and environmental factors, and individual child, family, and professional factors affecting timing of admission to hospital for children under five years of age with a serious infectious illness (SII). Methods An explanatory modified grounded theory design was used in collaboration with parents. Two stages of data …
A Qualitative Study Of Carer Contributions To Hf Self-Care Following Participation In The Rehabilitation Enablement In Chronic Heart Failure (Reach-Hf) Trial. 18th Wfot Congress, Paris 28-21 August 2022, M Noonan
School of Health Professions
No abstract provided.
A Review On The Modelling Of Wave-Structure Interactions Based On Openfoam, L Huang, Y Li, D Benites-Munoz, Cw Windt, A Feichtner, S Tavakoli, J Davidson, R Paredes, T Quintuna, E Ransley, M Colombo, M Li, P Cardiff, G Tabor
A Review On The Modelling Of Wave-Structure Interactions Based On Openfoam, L Huang, Y Li, D Benites-Munoz, Cw Windt, A Feichtner, S Tavakoli, J Davidson, R Paredes, T Quintuna, E Ransley, M Colombo, M Li, P Cardiff, G Tabor
School of Engineering, Computing and Mathematics
The modelling of wave-structure interaction (WSI) has significant applications in understanding natural processes as well as securing the safety and efficiency of marine engineering. Based on the technique of Computational Fluid Dynamics (CFD) and the open-source simulation framework - OpenFOAM, this paper provides a state-of-the-art review of WSI modelling methods. The review categorises WSI scenarios and suggests their suitable computational approaches, concerning a rigid, deformable or porous structure in regular, irregular, non-breaking or breaking waves. Extensions of WSI modelling for wave-structure-seabed interactions and various wave energy converters are also introduced. As a result, the present review aims to help understand …
Performance Of Deep-Sea Habitat Suitability Models Assessed Using Independent Data, And Implications For Use In Area-Based Management, Kerry L. Howell, Kyran Graves, Giulia La Bianca
Performance Of Deep-Sea Habitat Suitability Models Assessed Using Independent Data, And Implications For Use In Area-Based Management, Kerry L. Howell, Kyran Graves, Giulia La Bianca
School of Biological and Marine Sciences
Marine spatial management requires accurate data on species and habitat distributions. For the deep sea, these data are lacking. Habitat suitability modelling offers a robust defensible means to fill data gaps, provided models are sufficiently reliable. We tested the performance of published models of 2 deep-sea habitat-forming taxa at low and high resolutions (~1 km and 200 m grid-cell size), across the extended exclusive economic zones of the UK and Ireland. We constructed new data-rich models and compared new and old estimates of the area of habitat protected, noting changes in the protected area network since 2015. Results of independent …
Virtual Care And The Inverse Care Law: Implications For Policy, Practice, Research, Public And Patients, H Alami, P Lehoux, Se Shaw, Et Al
Virtual Care And The Inverse Care Law: Implications For Policy, Practice, Research, Public And Patients, H Alami, P Lehoux, Se Shaw, Et Al
Peninsula Medical School
Virtual care spread rapidly at the outbreak of the COVID-19 pandemic. Restricting in-person contact contributed to reducing the spread of infection and saved lives. However, the benefits of virtual care were not evenly distributed within and across social groups, and existing inequalities became exacerbated for those unable to fully access to, or benefit from virtual services. This “perspective” paper discusses the extent to which challenges in virtual care access and use in the context of COVID-19 follow the Inverse Care Law. The latter stipulates that the availability and quality of health care is inversely proportionate to the level of population …
Implementing Affordable Socially Assistive Pet Robots In Care Homes Before And During The Covid-19 Pandemic: Stratified Cluster Randomized Controlled Trial And Mixed Methods Study, Hannah Bradwell, Katie J. Edwards, Rhona Winnington, Serge Thill, Victoria Allgar, Ray B. Jones
Implementing Affordable Socially Assistive Pet Robots In Care Homes Before And During The Covid-19 Pandemic: Stratified Cluster Randomized Controlled Trial And Mixed Methods Study, Hannah Bradwell, Katie J. Edwards, Rhona Winnington, Serge Thill, Victoria Allgar, Ray B. Jones
School of Nursing and Midwifery
No abstract provided.
It’S Not You, It’S Me: A Review Of Individual Differences In Visuo-Spatial Perspective Taking., S Samuel, G Cole, M Eacott
It’S Not You, It’S Me: A Review Of Individual Differences In Visuo-Spatial Perspective Taking., S Samuel, G Cole, M Eacott
School of Psychology
Visuo-spatial perspective taking (VSPT) concerns the ability to understand something about the visual relationship between an Agent or observation point on the one hand, and a target or scene on the other. Despite its importance to a wide variety of other abilities, from communication to navigation, and decades of research, there is as yet no theory of VSPT. Indeed, the heterogeneity of results from different (and sometimes the same) VSPT tasks point to a complex picture suggestive of multiple VSPT strategies, individual differences in performance, and context-specific factors that together have a bearing on both the efficiency and accuracy of …
Pharmacogenomics: An Opportunity For Personalised Psychotropic Prescribing In Adults With Intellectual Disabilities, Bhathika Perera, Charles Steward, Ken Courtenay, Timothy Andrews, Rohit Shankar
Pharmacogenomics: An Opportunity For Personalised Psychotropic Prescribing In Adults With Intellectual Disabilities, Bhathika Perera, Charles Steward, Ken Courtenay, Timothy Andrews, Rohit Shankar
Peninsula Medical School
There is growing evidence for the use of pharmacogenomics in psychotropic prescribing. People with intellectual disabilities are disproportionately prescribed psychotropics and are at risk of polypharmacy. There is an urgent need for safeguards to prevent psychotropic overprescribing but it is equally crucial that this population is not left behind in such exciting initiatives. Understanding how genetic variations affect medications is a step towards personalised medicine. This may improve personalised prescribing for people with intellectual disabilities, especially given the high rate of psychiatric and behavioural problems in this population. Our editorial explores opportunities and challenges that pharmacogenomics offers for the challenges …
A Design Space Exploration Methodology For Enabling Tensor Train Decomposition In Edge Devices, Milad Kokhazadeh, Georgios Keramidas, Vasilios Kelefouras, Iakovos Stamoulis
A Design Space Exploration Methodology For Enabling Tensor Train Decomposition In Edge Devices, Milad Kokhazadeh, Georgios Keramidas, Vasilios Kelefouras, Iakovos Stamoulis
School of Engineering, Computing and Mathematics
No abstract provided.
Dental Education In Primary Care: 14 Years Of Peninsula Dental School, Christopher Tredwin, Sally Hanks, Rob Witton, Ewen Mccoll, Cathy Coelho
Dental Education In Primary Care: 14 Years Of Peninsula Dental School, Christopher Tredwin, Sally Hanks, Rob Witton, Ewen Mccoll, Cathy Coelho
Peninsula Dental School
AbstractPeninsula Dental School, established in 2006, was the UK's first new dental school in 40 years. It had the freedom to develop a completely new dental education curriculum planned on pedagogic thinking, designed to equip the dental care professionals of the twenty-first century. This was based on three distinct pillars: professionalism (developing a student's trust in their own autonomy); dental skills of the highest order (not just technical skills but also communication skills); and social engagement. As such, a truly innovative approach to dental education was created that has strong roots in evidence.This paper describes the University of Plymouth Peninsula …
Outcome And Mortality Of Hospital Admission With Covid-19 For Individuals With Parkinsonian Syndromes, L Sorrell, A King, J Inches, J Rideout, Jr Sneyd, C Kobylecki, R Chaudhuri, R Walker, H Martin, C Carroll
Outcome And Mortality Of Hospital Admission With Covid-19 For Individuals With Parkinsonian Syndromes, L Sorrell, A King, J Inches, J Rideout, Jr Sneyd, C Kobylecki, R Chaudhuri, R Walker, H Martin, C Carroll
Peninsula Medical School
No abstract provided.