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Longitudinal Expression Profiling Identifies A Poor Risk Subset Of Patients With Abc-Type Diffuse Large B Cell Lymphoma, F Bewicke-Copley, K Korfi, S Araf, Et Al Aug 2022

Longitudinal Expression Profiling Identifies A Poor Risk Subset Of Patients With Abc-Type Diffuse Large B Cell Lymphoma, F Bewicke-Copley, K Korfi, S Araf, Et Al

Peninsula Medical School

Despite the effectiveness of immuno-chemotherapy, 40% of patients with diffuse large B-cell lymphoma (DLBCL) experience relapse or refractory disease. Longitudinal studies have previously focused on the mutational landscape of relapse but fell short of providing a consistent relapse-specific genetic signature. In our study, we have focussed attention on the changes in gene expression profile accompanying DLBCL relapse using archival paired diagnostic/relapse specimens from 38 de novo DLBCL patients. Cell of origin remained stable from diagnosis to relapse in 80% of patients, with only a single patient showing COO switching from ABC to GCB. Analysis of the transcriptomic changes that occur …

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Supporting The Transition From Recent Graduate To Trainee; The Educational Transition Document, Sally Hanks Aug 2022

Supporting The Transition From Recent Graduate To Trainee; The Educational Transition Document, Sally Hanks

Peninsula Dental School

No abstract provided.

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Predictors Of Emotional Distress In Uveal Melanoma Survivors: A Systematic Review, C Davies, Sl Brown, P Fisher, L Hope-Stone, Et Al Aug 2022

Predictors Of Emotional Distress In Uveal Melanoma Survivors: A Systematic Review, C Davies, Sl Brown, P Fisher, L Hope-Stone, Et Al

School of Psychology

Uveal melanoma (UM) survivors can experience significant emotional distress, although the factors underpinning this are poorly understood. Systematic reviews of distress in UM only include cross-sectional studies, thereby limiting our understanding of causal factors. This review identified prospective clinical, demographic, social and psychological predictors of distress in UM survivors. A systematic search of the literature for English language prospective studies was conducted. Thirteen papers, reporting data from seven unique datasets were included in a narrative synthesis of the results. Younger age (3 studies from 3 datasets), physical health (including visual impairment, ocular symptoms, and other UM-related factors; 3 studies from …

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Protocol: Remote Care As The ‘New Normal’? Multi-Site Case Study In Uk General Practice, T Greenhalgh, Se Shaw, Nishio A Alvarez, A Booth, R Byng, A Clarke, F Dakin, R Davies, S Faulkner, N Hemmings, L Husain, A Kalin, E Ladds, L Moore, R Rosen, S Rybczynska-Bunt, J Wherton, S Wieringa Aug 2022

Protocol: Remote Care As The ‘New Normal’? Multi-Site Case Study In Uk General Practice, T Greenhalgh, Se Shaw, Nishio A Alvarez, A Booth, R Byng, A Clarke, F Dakin, R Davies, S Faulkner, N Hemmings, L Husain, A Kalin, E Ladds, L Moore, R Rosen, S Rybczynska-Bunt, J Wherton, S Wieringa

Peninsula Medical School

Background: Following a pandemic-driven shift to remote service provision, UK general practices offer telephone, video or online consultation options alongside face-to-face. This study explores practices’ varied experiences over time as they seek to establish remote forms of accessing and delivering care. Methods: This protocol is for a mixed-methods multi-site case study with co-design and national stakeholder engagement. 11 general practices were selected for diversity in geographical location, size, demographics, ethos, and digital maturity. Each practice has a researcher-in-residence whose role is to become familiar with its context and activity, follow it longitudinally for two years using interviews, public-domain documents and …

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Towards The Geographies Of Loneliness: Interpreting The Spaces Of Loneliness In Farming Contexts, Mark Holton, Mark Riley, Gina Kallis Aug 2022

Towards The Geographies Of Loneliness: Interpreting The Spaces Of Loneliness In Farming Contexts, Mark Holton, Mark Riley, Gina Kallis

School of Geography, Earth and Environmental Sciences

No abstract provided.

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Soils, Science And Community Action (Soilscan): A Citizen Science Tool To Empower Community-Led Land Management Change In East Africa, C Kelly, M Wynants, A Patrick, A Taylor, F Mkilema, M Nasseri, S Lewin, L Munishi, K Mtei, P Ndakidemi, W Blake Aug 2022

Soils, Science And Community Action (Soilscan): A Citizen Science Tool To Empower Community-Led Land Management Change In East Africa, C Kelly, M Wynants, A Patrick, A Taylor, F Mkilema, M Nasseri, S Lewin, L Munishi, K Mtei, P Ndakidemi, W Blake

School of Geography, Earth and Environmental Sciences

Pastoralist communities worldwide face complex challenges regarding food and feed productivity. Primary production systems are under stress, nutritional choices are changing and the relationship between development and agriculture is undergoing profound transformation. Under increasing pressure from climate and land use change, East African agro-pastoral systems are approaching a tipping point in terms of land degradation. There is an urgent need for evidence-led sustainable land management interventions to reverse degradation of natural resources that support food and water security. A key barrier, however, is a lack of high spatial resolution soil health data wherein collecting such information for each individual community …

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Building Lexical Networks: Preschoolers Extract Different Types Of Information In Cross-Situational Learning, C-H Chen, C Yu Aug 2022

Building Lexical Networks: Preschoolers Extract Different Types Of Information In Cross-Situational Learning, C-H Chen, C Yu

School of Psychology

Children's everyday learning environment is semantically structured. For example, semantically related things (e.g., fork and spoon) usually co-occur in the same contexts. The current study examines the effects of semantically structured contexts on preschool-age children's (N = 65, 33 girls, age range: 52-68 months) use of statistical information to learn novel word-object mappings. Children were assigned into one of two conditions, in which objects from the same semantic category repeatedly co-occurred in the same trials (Same-category condition) or objects from different categories repeatedly co-occurred in the same trials (Different-categories condition). Children's word learning performance in the two conditions were comparable. …

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Factors Influencing Oral Health Behaviours, Access And Delivery Of Dental Care For Autistic Children And Adolescents: A Mixed‐Methods Systematic Review, Jo Erwin, Martha Paisi, Sarah Neill, Lorna Burns, Isaac Vassallo, Abigail Nelder, Jemma Facenfield, Urshla Devalia, T Vassallo, Robert Witton Aug 2022

Factors Influencing Oral Health Behaviours, Access And Delivery Of Dental Care For Autistic Children And Adolescents: A Mixed‐Methods Systematic Review, Jo Erwin, Martha Paisi, Sarah Neill, Lorna Burns, Isaac Vassallo, Abigail Nelder, Jemma Facenfield, Urshla Devalia, T Vassallo, Robert Witton

School of Nursing and Midwifery

AimThis study aimed to gather evidence on the factors that influence OH behaviours, access to and delivery of dental care for autistic CYP.DesignThis was a mixed-methods narrative systematic review.Data SourcesEmbase, Web of Science, Dentistry & Oral Sciences Source, MEDLINE, Psychinfo, Scopus, CINAHL, SocINDEX and grey literature were the data sources for this study.Review MethodsA systematic search was conducted for qualitative, quantitative and mixed-methods research studies from countries with a High Development Index that related to OH behaviours, access to and delivery of dental care for autistic CYP. Results were analysed using narrative synthesis.ResultsFrom 59 eligible studies, 9 themes were generated: …

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Developing Undergraduate Autism Education For Medical Students: A Qualitative Study, Y Dhuga, Y Feeney, L Gallaher, A White, Et Al Aug 2022

Developing Undergraduate Autism Education For Medical Students: A Qualitative Study, Y Dhuga, Y Feeney, L Gallaher, A White, Et Al

Peninsula Medical School

Background Autistic adults and children experience considerable health inequalities and have high rates of premature mortality, hospital admissions and emergency department visits. This is in part due to a lack of autism awareness in the healthcare and social care workforce. A new educational programme, Time for Autism (TfA), for medical students is being developed to address this challenge. This qualitative study was undertaken to support the development of the new programme in order to (1) understand the medical care experiences of parents of autistic children and (2) assess their views on the acceptability of the new TfA programme and willingness …

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Payment For Ecosystem Services In Peru: Assessing The Socio-Ecological Dimension Of Water Services In The Upper Santa River Basin, Rm Dextre, Ml Eschenhagen, M Camacho Hernández, S Rangecroft, Et Al Aug 2022

Payment For Ecosystem Services In Peru: Assessing The Socio-Ecological Dimension Of Water Services In The Upper Santa River Basin, Rm Dextre, Ml Eschenhagen, M Camacho Hernández, S Rangecroft, Et Al

School of Geography, Earth and Environmental Sciences

Increasing pressures on ecosystems in the Latin American region, as well as the adoption of multilateral conservation commitments, have led to the implementation of instruments that are economic in nature but oriented towards the recovery, conservation, and functioning of ecosystems such as Payment for Ecosystem Services (PES). In the Peruvian Andes, hydro-climatic factors and land-use changes are affecting the capacity of the ecosystems of the glaciated Cordillera Blanca to provide water services, in terms of both quality and quantity, to the main users of the Santa River basin. Thus, this study analyses how the socio-ecological interactions affect, and are affected …

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Meaningful Patient And Public Involvement In Digital Health Innovation, Implementation And Evaluation: A Systematic Review, Rebecca Baines, Hannah Bradwell, Katie Edwards, Sebastian Stevens, Samantha Prime, John Tredinnick‐Rowe, Miles Sibley, Arunangsu Chatterjee Aug 2022

Meaningful Patient And Public Involvement In Digital Health Innovation, Implementation And Evaluation: A Systematic Review, Rebecca Baines, Hannah Bradwell, Katie Edwards, Sebastian Stevens, Samantha Prime, John Tredinnick‐Rowe, Miles Sibley, Arunangsu Chatterjee

School of Nursing and Midwifery

AbstractIntroductionThe importance of meaningfully involving patients and the public in digital health innovation is widely acknowledged, but often poorly understood. This review, therefore, sought to explore how patients and the public are involved in digital health innovation and to identify factors that support and inhibit meaningful patient and public involvement (PPI) in digital health innovation, implementation and evaluation.MethodsSearches were undertaken from 2010 to July 2020 in the electronic databases MEDLINE, EMBASE, PsycINFO, CINAHL, Scopus and ACM Digital Library. Grey literature searches were also undertaken using the Patient Experience Library database and Google Scholar.ResultsOf the 10,540 articles identified, 433 were included. …

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The Gut Microbiome Variability Of A Butterflyfish Increases On Severely Degraded Caribbean Reefs, Friederike Clever, Jade M. Sourisse, Richard F. Preziosi, Jonathan A. Eisen, E. Catalina Rodriguez Guerra, Jarrod J. Scott, Laetitia G.E. Wilkins, Andrew H. Altieri, W. Owen Mcmillan, Matthieu Leray Jul 2022

The Gut Microbiome Variability Of A Butterflyfish Increases On Severely Degraded Caribbean Reefs, Friederike Clever, Jade M. Sourisse, Richard F. Preziosi, Jonathan A. Eisen, E. Catalina Rodriguez Guerra, Jarrod J. Scott, Laetitia G.E. Wilkins, Andrew H. Altieri, W. Owen Mcmillan, Matthieu Leray

School of Biological and Marine Sciences

AbstractEnvironmental degradation has the potential to alter key mutualisms that underlie the structure and function of ecological communities. How microbial communities associated with fishes vary across populations and in relation to habitat characteristics remains largely unknown despite their fundamental roles in host nutrition and immunity. We find significant differences in the gut microbiome composition of a facultative coral-feeding butterflyfish (Chaetodon capistratus) across Caribbean reefs that differ markedly in live coral cover (∼0–30%). Fish gut microbiomes were significantly more variable at degraded reefs, a pattern driven by changes in the relative abundance of the most common taxa potentially associated with stress. …

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Meaningful Activities On An Acute Older People’S Ward, Hayley Townsend Jul 2022

Meaningful Activities On An Acute Older People’S Ward, Hayley Townsend

South West Clinical School Journal

Quarter 1 2021/22 RUNNER-UP #400WORDS: COVID-19 RESPONSE

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Covid-19: Have We Been More In Tune With Our Patients?, Sarah Brown Jul 2022

Covid-19: Have We Been More In Tune With Our Patients?, Sarah Brown

South West Clinical School Journal

Quarter 1 2021/22 RUNNER-UP #400WORDS: COVID-19 RESPONSE

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Feedback And Spider Size Estimation: A Quantitative Investigation Into Whether Fear And Feedback Influences Size Estimation In Spiders, Amelia Clements Jul 2022

Feedback And Spider Size Estimation: A Quantitative Investigation Into Whether Fear And Feedback Influences Size Estimation In Spiders, Amelia Clements

The Plymouth Student Scientist

This paper investigated the link between trait fear in spider phobic participants and size estimation of an imagined spider. However, previous research has suggested that there is a strong association between fear and size estimation bias in phobic individuals, which could be mediating spider phobia. To reduce this bias, false verbal feedback was given to spider phobic participants to test whether spider size estimation can be reduced through convincing participants that they are less afraid of spiders than the average person. Participants were either in the no feedback or feedback condition. The feedback condition were told that they are less …

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A Computational Fluid Dynamic, Experimental And Empirical Analysis Of University Of Plymouth's Brunel Laboratories Shell And Tube Heat Exchanger, Luke Hill Jul 2022

A Computational Fluid Dynamic, Experimental And Empirical Analysis Of University Of Plymouth's Brunel Laboratories Shell And Tube Heat Exchanger, Luke Hill

The Plymouth Student Scientist

The aim of this paper is to analyses the University of Plymouth’s Brunel laboratories shell and tube heat exchanger using three investigative methods aiming to determine which method most accurately predicts the heat exchanger performance. The university heat exchanger, UHX, uses the TECQUIPMENT TD360C shell and tube heat exchanger but an experimental study could not be conducted so data was collated from previous experiments. This was used to calculate an experimental value for the overall heat transfer coefficient (U). Two empirical methods were used, the Kern and Bell-Delaware method. These two methods were developed in the mid to late 20th …

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Investigating Metformin & Syrosingopine's Synthetic Lethality In Pc3 & Thp-1 Cancer Cell Lines, Sophia V. Medeiros Jul 2022

Investigating Metformin & Syrosingopine's Synthetic Lethality In Pc3 & Thp-1 Cancer Cell Lines, Sophia V. Medeiros

The Plymouth Student Scientist

The oral antidiabetic, metformin, has been documented to have antineoplastic activity in various cancer cell lines, associated with the inhibition of mitochondrial complex I. However, pre-clinical studies have struggled to demonstrate such antineoplastic activity utilising metformin concentrations attainable with standard antidiabetic dosing. Research has revealed that metformin combined with the anti-hypertensive drug, syrosingopine, lowers metformin’s therapeutic threshold and sensitizes cancer cells to killing, by inhibiting monocarboxylate transporters (MCT)1/MCT4. The potent interaction between these drugs elicits a synthetic lethality, specific to transformed cells. This preliminary study aimed to investigate metformin’s antineoplastic effects and its synergistic relationship with syrosingopine by measuring cell …

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Can We Improve Self-Esteem By Reducing Instagram Usage, Via A Novel Online Imagery Intervention?, Sabrina Ryan Jul 2022

Can We Improve Self-Esteem By Reducing Instagram Usage, Via A Novel Online Imagery Intervention?, Sabrina Ryan

The Plymouth Student Scientist

Self-esteem has far-reaching effects on our lives. Low self-esteem can cause negative body image and depression, and therefore it is vital for psychologists to find ways to improve individuals’ self-esteem. Recent research has shown that social media usage is negatively associated with self-esteem, prompting the theory that interventions which reduce individuals’ social media usage could result in higher levels of self-esteem. Our study aimed to test this theory by using a novel online imagery intervention, developed from Functional Imagery Training (FIT), to reduce Instagram usage in participants from Plymouth University. Results showed that the novel online imagery intervention was not …

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Quantifying Beach Variability Along The Teignmouth-Dawlish Seawall, Caitlin Perry Jul 2022

Quantifying Beach Variability Along The Teignmouth-Dawlish Seawall, Caitlin Perry

The Plymouth Student Scientist

An investigation into the variation of beach sediment levels fronting a seawall was conducted for both Teignmouth and Dawlish, on the south coast of Devon, UK. The aim was to quantify the levels of beach variability along the length of the seawall and discuss this in line with plans to re-develop sections of the existing structure. It was predicted that Sprey Point, a section of the seawall that protrudes into the surf-zone, would interrupt the littoral transport of sediment at Teignmouth. At Dawlish, it was expected that the presence of groynes positioned along the beach would also influence the transport …

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Finite Element Analysis Of A Total Wrist Replacement: Determining Implant Lifetime Due To Fatigue, Edward Alton Jul 2022

Finite Element Analysis Of A Total Wrist Replacement: Determining Implant Lifetime Due To Fatigue, Edward Alton

The Plymouth Student Scientist

Total wrist replacement is a surgery in which an implant is used to help a patient regain a full range of painless movement in their wrist. However, there is little data to suggest the lifetime of implants when being used, implants should last as long as possible to reduce possible harm to patients and reduce the need of more surgery. This paper aims to use finite element analysis (FEA) to develop a model of a total wrist replacement and therefore develop a fatigue analysis based on the typical use of the implant. Results from the FEA were further corroborated using …

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Ecological Impacts Of The Non-Native Macrophyte Crassula Helmsii On Freshwater Macroinvertebrate Assemblages In Dartmoor National Park, Uk, Salvatore Giordano Jul 2022

Ecological Impacts Of The Non-Native Macrophyte Crassula Helmsii On Freshwater Macroinvertebrate Assemblages In Dartmoor National Park, Uk, Salvatore Giordano

The Plymouth Student Scientist

Invasive species are a major threat to biodiversity globally. In freshwater ecosystems, invasive macrophytes are one of the most significant hazards. This study evaluated the impacts of the non-native macrophyte Crassula helmsii on macroinvertebrate assemblages in ponds in Dartmoor National Park, UK. Sampled ponds differed in the extent of invasion, being uninvaded, partially invaded and dominated by Crassula. Samples were taken from macrophyte stands using a hand net and taxa identified to the lowest taxonomic level possible in the laboratory. Assemblages were compared using univariate and multivariate approaches. Taxonomic richness and Shannon-Wiener Index did not differ significantly between invasion categories. …

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Construction Of Mega Individuals Competency Model In Business Environment: A Grounded Theory Approach, Beilei Huang, Jinhua Zhang, Xiyuan Li Jul 2022

Construction Of Mega Individuals Competency Model In Business Environment: A Grounded Theory Approach, Beilei Huang, Jinhua Zhang, Xiyuan Li

Plymouth Business School

The purpose of this research is to explore the new practices derived from the influences of information technology among a certain group, i.e., “mega individuals”. Based on Grounded Theory and interviews from 53 companies, which consist of responses from 56 domestic and international founders, entrepreneurs, professional managers, partners and business elites, this study expounds that “mega individuals”, who constantly develop individual attainment and ability under the influence of business ecosystem evolution, have broken the traditional employment relationship. Through Grounded Theory, the following conclusion can be drawn: “mega individuals” are composed of three key traits: compound ability, collaboration ability and personal …

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Artificial Light At Night Reverses Monthly Foraging Pattern Under Simulated Moonlight, Svenja Tidau, Jack Whittle, Stuart R. Jenkins, Thomas W. Davies Jul 2022

Artificial Light At Night Reverses Monthly Foraging Pattern Under Simulated Moonlight, Svenja Tidau, Jack Whittle, Stuart R. Jenkins, Thomas W. Davies

School of Biological and Marine Sciences

Mounting evidence shows that artificial light at night (ALAN) alters biological processes across levels of organization, from cells to communities. Yet, the combined impacts of ALAN and natural sources of night-time illumination remain little explored. This is in part due the lack of accurate simulations of the complex changes moonlight intensity, timing and spectra throughout a single night and lunar cycles in laboratory experiments. We custom-built a novel system to simulate natural patterns of moonlight to test how different ALAN intensities affect predator–prey relationships over the full lunar cycle. Exposure to high intensity ALAN (10 and 50 lx) reversed the …

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Scoping Review: Scope Of Practice Of Nurse‐Led Services And Access To Care For People Experiencing Homelessness, Lucy Mcwilliams, Martha Paisi, Sandy Middleton, Jill Shawe, Anna Thornton, Matthew Larkin, Joanne Taylor, Jane Currie Jul 2022

Scoping Review: Scope Of Practice Of Nurse‐Led Services And Access To Care For People Experiencing Homelessness, Lucy Mcwilliams, Martha Paisi, Sandy Middleton, Jill Shawe, Anna Thornton, Matthew Larkin, Joanne Taylor, Jane Currie

School of Nursing and Midwifery

No abstract provided.

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Social Prescribing For Older People And The Role Of The Cultural Sector During The Covid-19 Pandemic: What Are Link Workers' Views And Experiences?, Stephanie Tierney, Caroline Potter, Kathryn Eccles, Oluwafunmi Akinyemi, Jordan Gorenberg, Sebastien Libert, Geoff Wong, Amadea Turk, Kerryn Husk, Helen J. Chatterjee, Emma Webster, Beth Mcdougall, Harriet Warburton, Lucy Shaw, Kamal R. Mahtani Jul 2022

Social Prescribing For Older People And The Role Of The Cultural Sector During The Covid-19 Pandemic: What Are Link Workers' Views And Experiences?, Stephanie Tierney, Caroline Potter, Kathryn Eccles, Oluwafunmi Akinyemi, Jordan Gorenberg, Sebastien Libert, Geoff Wong, Amadea Turk, Kerryn Husk, Helen J. Chatterjee, Emma Webster, Beth Mcdougall, Harriet Warburton, Lucy Shaw, Kamal R. Mahtani

Peninsula Medical School

Abstract Older people's well-being can be bolstered by engaging with cultural activities and venues. They may be encouraged to try cultural offers by a link worker as part of social prescribing. However, the cultural sector, like all parts of life, was affected by the COVID-19 pandemic; this has had implications for cultural offers available to link workers. A study was conducted to explore the views and experiences of link workers in using the cultural sector within social prescribing, particularly for older people (aged 60+) during the pandemic. An online questionnaire was distributed to and completed by link workers in the …

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Testing A Family Supportive End Of Life Care Intervention In A Chinese Neonatal Intensive Care Unit: A Quasi- Experimental Study With A Non-Randomized Controlled Trial Design, R Zhang, Qian Tang, Li Hui Zhu, Xiao Ming Peng, N Zhang, Yu E.E. Xiong, Hm Chen, Lk Chen, Dan Luo, Xun Li, Jos M. Latour Jul 2022

Testing A Family Supportive End Of Life Care Intervention In A Chinese Neonatal Intensive Care Unit: A Quasi- Experimental Study With A Non-Randomized Controlled Trial Design, R Zhang, Qian Tang, Li Hui Zhu, Xiao Ming Peng, N Zhang, Yu E.E. Xiong, Hm Chen, Lk Chen, Dan Luo, Xun Li, Jos M. Latour

School of Nursing and Midwifery

No abstract provided.

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Continuity, Change And Challenge: Unearthing The (Fr)Agility Of Teacher Education, O Mcgarr, R Passy, J Murray, H Liu Jul 2022

Continuity, Change And Challenge: Unearthing The (Fr)Agility Of Teacher Education, O Mcgarr, R Passy, J Murray, H Liu

Plymouth Institute of Education

In this final article, we bring together the issues raised by authors included in this special issue. We start by describing the current situation in our own countries, partly to highlight the different ways in which nations are responding in the longer term to the pandemic, but also to draw attention to the similarity of experience–of educators using digital technology, of concern with maintaining the supply of teachers, of the challenges relating to lockdowns–during its peak. We then reflect on the systemic issues that have been raised by the authors in this issue: what we call the (fr)agility of the …

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Socioeconomic Inequality Of Long-Term Care For Older People With And Without Dementia In England, B Hu, S Read, R Wittenberg, N Brimblecombe, Et Al Jul 2022

Socioeconomic Inequality Of Long-Term Care For Older People With And Without Dementia In England, B Hu, S Read, R Wittenberg, N Brimblecombe, Et Al

Peninsula Medical School

Ensuring distributive fairness in the long-term care sector is vitally important in the context of global population ageing and rising care needs. This study, part of the DETERMIND (DETERMinants of quality of life, care and costs, and consequences of INequalities in people with Dementia and their carers) programme, investigates socioeconomic inequality and inequity in the utilisation of long-term care for older people with and without dementia in England. The data come from three waves of the English Longitudinal Study of Ageing (ELSA, Waves 6–8, N = 16,458). We find that older people with dementia have higher levels of care needs …

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Durvalumab As Monotherapy And In Combination Therapy In Patients With Lymphoma Or Chronic Lymphocytic Leukemia: The Fusion Nhl 001 Trial, C Casulo, A Santoro, G Cartron, Et Al Jul 2022

Durvalumab As Monotherapy And In Combination Therapy In Patients With Lymphoma Or Chronic Lymphocytic Leukemia: The Fusion Nhl 001 Trial, C Casulo, A Santoro, G Cartron, Et Al

Peninsula Medical School

Background Studies suggest that immune checkpoint inhibitors may represent a promising strategy for boosting immune responses and improving the antitumor activity of standard therapies in patients with relapsed/refractory hematologic malignancies. Aims Phase 1/2 FUSION NHL 001 was designed to determine the safety and efficacy of durvalumab, an anti-programmed death ligand 1 (PD-L1) antibody, combined with standard-of-care therapies for lymphoma or chronic lymphocytic leukemia (CLL). Methods and Results The primary endpoints were to determine the recommended phase 2 dose of the drugs used in combination with durvalumab (durvalumab was administered at the previously recommended dose of 1500 mg every 4 weeks) …

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Improving The Intensive Care Experience From The Perspectives Of Different Stakeholders, Jos M. Latour, Nancy Kentish-Barnes, Theresa Jacques, Marc Wysocki, Elie Azoulay, Victoria Metaxa Jul 2022

Improving The Intensive Care Experience From The Perspectives Of Different Stakeholders, Jos M. Latour, Nancy Kentish-Barnes, Theresa Jacques, Marc Wysocki, Elie Azoulay, Victoria Metaxa

School of Nursing and Midwifery

No abstract provided.

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