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The Effect Of Seagrass Components On The Associated Bacterial Diversity And Antimicrobial Activity In Zostera Marina, Caroline Millan Dec 2022

The Effect Of Seagrass Components On The Associated Bacterial Diversity And Antimicrobial Activity In Zostera Marina, Caroline Millan

The Plymouth Student Scientist

Seagrasses are marine angiosperms located in intertidal and sub-tidal waters. They are important ecosystem engineers that play a crucial role in the structure of habitats, allowing them to support a comprehensive diversity of life. Through fundamental ecological processes and the generation of niches, each seagrass species has aggregated an associated microbiome that lives among the various seagrass components and exhibit symbiotic relations. There have been studies investigating the diversity of the associated bacteria and elements of the resulting microbial activity, however these have primarily focused on tropical seagrass species and have failed to examine the extent of this bioactivity. This …

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Age Differences In Facial First Impressions Of Traits Associated With Trustworthiness, Gulbeyaz Altun Dec 2022

Age Differences In Facial First Impressions Of Traits Associated With Trustworthiness, Gulbeyaz Altun

The Plymouth Student Scientist

Older adults are more susceptible to becoming fraud victims due to increased generalised trust in others for assistance, leading to deception. Age differences in first impressions of unfamiliar faces on traits associated with trustworthiness was explored in this study. Investigating the various interpretations of trustworthiness across age has not been previously led. Using a data-driven approach, the key traits interpreted from trustworthiness were used in a trait rating task. Older adults provided higher ratings and showed an own-age bias for the traits trustworthy, honest, reliable, and loyal compared to younger adults, but not for the trait considerate. Mean trait ratings …

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Investigating The Impacts Of Heterotrophic Nutrition On Acropora Microclados, Heather O'Keefe Dec 2022

Investigating The Impacts Of Heterotrophic Nutrition On Acropora Microclados, Heather O'Keefe

The Plymouth Student Scientist

The Scleractinian coral Acropora microclados is a commercially important species that functions as both an autotroph and heterotroph. In ex situ coral aquaculture, elucidating an optimal diet to improve growth and resilience is critical in improving the sustainability and success of rearing corals for trade and conservation. To investigate the impacts of diet on A. microclados, three groups of 15 nubbins were kept under three different feeding regimes for three months at the National Marine Aquarium, Plymouth, UK. One group was fed nothing, the control (CTL), one group fed Artemia salina nauplii (ART) and one group fed a mixed diet …

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Public Engagement In Environmental Issues: Investigating Factors Of Disengagement From An Individual And Organisational Perspective, Anna Carne Dec 2022

Public Engagement In Environmental Issues: Investigating Factors Of Disengagement From An Individual And Organisational Perspective, Anna Carne

The Plymouth Student Scientist

Anthropogenic climate change is now a major issue facing the public, government, and environmental non-governmental organisations (ENGOs) alike. In order for climate goals set out by the conference of the parties (COP) summits to be reached, the public must be involved and feel a sense of responsibility to act. Though there have been previous studies investigating the levels of engagement and the actions that individuals take, the impact of certain factors on engagement is still not well understood. A UK survey open for two weeks and shared on social media was conducted. The survey consisted of open and closed questions …

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An Investigation Into The Effects Of Weekly Habitual And Targeted Caffeine Consumption On Adult Runners' Endurance, Speed, And Mood, Elise Lucas Dec 2022

An Investigation Into The Effects Of Weekly Habitual And Targeted Caffeine Consumption On Adult Runners' Endurance, Speed, And Mood, Elise Lucas

The Plymouth Student Scientist

BACKGROUND: Caffeine is a commonly consumed recreational drug which is also highly regarded as an ergogenic aid. Generally, users partake in sporadic and habitual caffeine consumption for functional benefits such as alertness or for social purposes, but targeted consumption prior to exercise is claimed to aid endurance, increase speed, and improve mood during exercise. OBJECTIVES: This questionnaire-based study aimed to evaluate the effect of targeted and randomised caffeine consumption on endurance, speed, and perceived mood in runners of varying levels. SUBJECTS: 489 subjects from 27 different countries (predominantly United States of America and United Kingdom) participated in the study (50.7% …

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Reasons For Living Following An Acquired Brain Injury: A Mixed Thematic Analysis, Catalana Parris Dec 2022

Reasons For Living Following An Acquired Brain Injury: A Mixed Thematic Analysis, Catalana Parris

The Plymouth Student Scientist

Considering the prevalence of acquired brain injury (ABI) and the concerning statistics around the associated risk of problematic substance use, impacted mental health, and suicidality (3-4 greater risk of suicidality in those with TBI), and the lack of qualitative, recent, and UK based research. This study aimed to explore what people’s reasons for living after ABI were. Individuals living with ABI were recruited via BABICM (British Association of Brain Injury and Complex Case Management) to participate in semi-structured interviews. A mixed thematic analysis was conducted on the transcripts using the themes from Knight, Norman and Simpson (2020) as a framework …

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Marine Mammals In The Western English Channel, A Survey From The Rame Head Peninsula, Janine Douglas Dec 2022

Marine Mammals In The Western English Channel, A Survey From The Rame Head Peninsula, Janine Douglas

The Plymouth Student Scientist

This paper presents the first records of marine mammals in Plymouth Sound National Marine Park (NMP), and over 1000 individual animal observations were recorded. Marine mammal temporal and spatial distributions were quantified for the first time at Rame Head, a vantage point overlooking the NMP and the Western English Channel. A biodiversity hotspot, the Western English Channel supports many species of marine mammals, yet it is subject to increasing anthropogenic pressures, such as heavy shipping, which could significantly impact populations. Whilst marine mammals are well studied, their distributions and population sizes remain largely unknown; effective conservation of these animals requires …

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Trends And Issues Involving Disabilities In Higher Education, Jm Kauffman, D Anastasiou, M Felder, J Lopes, Ba Hallenbeck, G Hornby, B Ahrbeck Dec 2022

Trends And Issues Involving Disabilities In Higher Education, Jm Kauffman, D Anastasiou, M Felder, J Lopes, Ba Hallenbeck, G Hornby, B Ahrbeck

More Faculty of Arts, Humanities and Business Research

People with disabilities have often been discriminated against in higher education; however, many institutions of higher education find ways of providing access to higher education for those with most forms of disabilities. Progress has been made in providing such access but undoubtedly there is still a need for more disability awareness, anti-stigma, and anti-discrimination training. At the same time higher education requirements, by default, involve higher cognitive capabilities. Some disabilities, those involving severe limitations of cognitive functioning, face insurmountable difficulties in meeting these higher intellectual demands, even with the most reasonable accommodations. Teacher education, for example, requires special attention to …

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Composite Dynamics In Sp(2N) Gauge Theories, Jong Wan Lee, Ed Bennett, Deog Ki Hong, Ho Hsiao, C. J.David Lin, Biagio Lucini, Maurizio Piai, Davide Vadacchino Dec 2022

Composite Dynamics In Sp(2N) Gauge Theories, Jong Wan Lee, Ed Bennett, Deog Ki Hong, Ho Hsiao, C. J.David Lin, Biagio Lucini, Maurizio Piai, Davide Vadacchino

School of Engineering, Computing and Mathematics

Sp(2N) gauge theories with fermonic matter provide an ideal laboratory to build extensions of the standard model based on novel composite dynamics. Examples include composite Higgs along with top partial compositeness and composite dark matter. Without fermions, their study also complements those based on SU(Nc) gauge theories with which they share a common sector in the large Nc = 2N limit. We report on our recent progress in the numerical studies of Sp(2N) gauge theories discretised on a four-dimensional Euclidean lattice. In particular, we present preliminary results for the low-lying mass spectra of mesons and chimera baryons in the theories …

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The Association Between Adverse Childhood Experiences, Self-Silencing Behaviours And Symptoms In Women With Fibromyalgia., Alison M. Bacon, Leah White Dec 2022

The Association Between Adverse Childhood Experiences, Self-Silencing Behaviours And Symptoms In Women With Fibromyalgia., Alison M. Bacon, Leah White

School of Psychology

Poor adult health has consistently been associated with Adverse Childhood Experiences (ACEs). The process is not fully understood but is likely to involve a complex interaction of biological and psychosocial factors. Early life stress can affect the developing brain resulting in long-term hyper-responses to stress and raised inflammatory biomarkers. Women with fibromyalgia syndrome (FMS) frequently report ACEs and also self-sacrificial behaviours whereby they repress their own needs and emotions to preserve personal relationships. This behavioural profile (termed self-silencing) may develop following ACEs but has not previously been considered in the context of FMS. This study examined whether self-silencing mediates the …

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Developing A Mcdm-Based Framework For Achieving Circular Economy Through Sustainable Ship Recycling, B Mannan, Mj Rizvi, M Dai Dec 2022

Developing A Mcdm-Based Framework For Achieving Circular Economy Through Sustainable Ship Recycling, B Mannan, Mj Rizvi, M Dai

School of Engineering, Computing and Mathematics

As a result of the growing global population, concerns about the energy crisis and sustainability issues are studied by researchers and policymakers to make a transit from a linear to a circular economy. However, the recycling of end-of-life (EOL) ships has long been a severely marginalized research area in the field of circular economy, and many EOL ships are still adhering to the outdated linear model. The number, size, and volume of ships being built around the world have consistently increased during the past 20 years. In near future, the global ship recycling volume is anticipated to increase dramatically which …

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Taking The Biscuit: Defining Excessive Quantities Of Free Refreshments In A Healthcare Library, Andrew Tabner, Stuart G. Spicer, Kerryn Husk, Holly Blake, Caroline White, Suzanne Toft, Graham Johnson Dec 2022

Taking The Biscuit: Defining Excessive Quantities Of Free Refreshments In A Healthcare Library, Andrew Tabner, Stuart G. Spicer, Kerryn Husk, Holly Blake, Caroline White, Suzanne Toft, Graham Johnson

Peninsula Medical School

Evidence suggests that complementary hot drinks and biscuits benefit an overworked and highly stressed healthcare workforce. But when signage in healthcare libraries asks patrons not to consume “excessive” quantities of free hot drinks and biscuits, how much is too much? Tabner and colleagues explore this resource allocation conundrumAs the festive season approaches, temperatures plummet, days shorten, and healthcare workers see glimmers of time off around the holidays, some might consider the provision of unlimited free hot drinks and biscuits a welcome token of appreciation; this is particularly the case for National Health Service staff, who are often felt to be …

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Withdrawing Antipsychotics For Challenging Behaviours In Adults With Intellectual Disabilities: Experiences And Views Of Prescribers, G De Kuijper, J De Haan, S Deb, R Shankar Dec 2022

Withdrawing Antipsychotics For Challenging Behaviours In Adults With Intellectual Disabilities: Experiences And Views Of Prescribers, G De Kuijper, J De Haan, S Deb, R Shankar

Peninsula Medical School

International current best practice recommends the discontinuation of antipsychotics for challenging behaviours in people with intellectual disabilities (ID), due to lack of evidence of efficacy and risks of harmful side-effects. In clinical practice, discontinuation may be difficult. The aim of this study was to gain insight into prescribers’ practice by investigating their experiences with the discontinuation of long-term antipsychotics for challenging behaviour. From professionals’ associations thirty-four registered ID physicians, psychiatrists and specialist mental healthcare nurses were recruited who completed an online questionnaire in this survey–study. Almost all participants had attempted to deprescribe antipsychotics for their patients with ID. Sixty-five percent …

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Tourists’ Selfies Storytelling: Preferences, Intentions, And Concerns For Practise In The Tourism And Hospitality Industry, Abdallah Elshaer, Rong Huang, Asmaa Marzouk Dec 2022

Tourists’ Selfies Storytelling: Preferences, Intentions, And Concerns For Practise In The Tourism And Hospitality Industry, Abdallah Elshaer, Rong Huang, Asmaa Marzouk

Plymouth Business School

Photography has recently received significant academic interest as a popular tourist activity. However, tourist selfie practises have not yet been thoroughly examined by tourism scholars. This study aimed to investigate tourist selfies storytelling and to determine if tourists'selfies at tourist destinations reveal specific aspects of the host destination, implying an embodiment of particular preferences, intentions, and motivations. In this study, an exploratory analysis employing a two-step qualitative approach was conducted. A semiotic analysis of 317 tourist selfie photos and two phases of in-depth interviews with eleven tourists visiting Egypt on a 7-day packaged tour were used. The findings reveal that …

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Traditional Beliefs, Practices, And Migration: A Risk To Malaria Transmission In Rural Nepal, Kr Awasthi, J Jancey, Aca Clements, Rk Sah, Et Al Dec 2022

Traditional Beliefs, Practices, And Migration: A Risk To Malaria Transmission In Rural Nepal, Kr Awasthi, J Jancey, Aca Clements, Rk Sah, Et Al

Peninsula Medical School

The study aimed to explore sociocultural factors influencing the risk of malaria and practices and beliefs towards malaria prevention, transmission and treatment in a remote village in Khatyad Rural Municipality (KRM) of Nepal. A sequential exploratory mixed methods approach was used. Qualitative data were collected through 25 one-on-one, in-depth interviews followed by a face-to-face household survey (n = 218) among people from a village in KRM believed to have a high risk of malaria. Traditional practices such as Chhaupadi requiring the seclusion of women during menstruation and post-partum, transhumance, and reliance on traditional healers for the management of malaria were …

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Barriers To Healthcare And Their Relationship To Well-Being And Social Support For Autistic Adults During Covid-19, Charlotte Featherstone, Richard A. Sharpe, Nick Axford, Sheena Asthana, Susan Ball, Kerryn Husk Dec 2022

Barriers To Healthcare And Their Relationship To Well-Being And Social Support For Autistic Adults During Covid-19, Charlotte Featherstone, Richard A. Sharpe, Nick Axford, Sheena Asthana, Susan Ball, Kerryn Husk

Peninsula Medical School

Aim: The present study aimed to investigate barriers to healthcare and their relationships to social and emotional well-being and intersectional inequalities for autistic adults during COVID-19 restrictions in the UK. Background: Autistic adults experience severe health inequalities and report more barriers to accessing health services compared to other both disabled and non-disabled populations. The COVID-19 pandemic has impacted many areas of society that may have increased vulnerability of autistic people to social and health inequalities, including delivery of healthcare from in-person to remote methods. Method: One hundred twenty-eight autistic adults who lived in the UK took part in an online …

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Psychoactive Space: Glimpses Of The Unknown, Mathew Emmett Dec 2022

Psychoactive Space: Glimpses Of The Unknown, Mathew Emmett

School of Art, Design and Architecture

No abstract provided.

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Imagining And Reimagining The Future Of Special And Inclusive Education, James M. Kauffman, Dimitris Anastasiou, Garry Hornby, Joao Lopes, Mack D. Burke, Marion Felder, Bernd Ahrbeck, Andrew Wiley Dec 2022

Imagining And Reimagining The Future Of Special And Inclusive Education, James M. Kauffman, Dimitris Anastasiou, Garry Hornby, Joao Lopes, Mack D. Burke, Marion Felder, Bernd Ahrbeck, Andrew Wiley

More Faculty of Arts, Humanities and Business Research

“Reimagination” is required to create a new vision of education that better serves individuals with disabilities. Imagination is a way of conceiving possibilities and probabilities. The future of special education is imagined within the limits of possibility and probability of “appropriate” education for children with special educational needs and disabilities. Education is reimagined for full inclusion without special education and an alternative reimagination of inclusive special education. Particular attention is given to the administrative structure of public education and to the training of teachers for the imagined approaches to special education. The importance of imagining special and inclusive education being …

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Endotoxin As A Marker For Water Quality, Anas A. Sattar, Christian R. Good, Margaux Saletes, João Brandão, Simon K. Jackson Dec 2022

Endotoxin As A Marker For Water Quality, Anas A. Sattar, Christian R. Good, Margaux Saletes, João Brandão, Simon K. Jackson

School of Biomedical Sciences

Background: Water quality testing is vital to protect human health. Current testing relies mainly on culture-based detection of faecal indicator organisms such as Escherichia coli (E.coli). However, bacterial cultures are a slow process, taking 24–48 h and requiring specialised laboratories and trained personnel. Access to such laboratories is often sparse in developing countries and there are many fatalities deriving from poor water quality. Endotoxin is a molecular component of Gram-negative bacterial cell walls and can be used to detect their presence in drinking water. Method: The current study used a novel assay (BacterisK) to rapidly detect endotoxin in various water …

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Real-Time Hybrid Testing Of A Floating Offshore Wind Turbine Using A Surrogate-Based Aerodynamic Emulator, Edward Ransley, Scott Brown, Emma Edwards, Tom Tosdevin, Kieran Monk, Alastair Reynolds, Deborah Greaves, Martyn Hann Dec 2022

Real-Time Hybrid Testing Of A Floating Offshore Wind Turbine Using A Surrogate-Based Aerodynamic Emulator, Edward Ransley, Scott Brown, Emma Edwards, Tom Tosdevin, Kieran Monk, Alastair Reynolds, Deborah Greaves, Martyn Hann

School of Engineering, Computing and Mathematics

Abstract Physical modelling of floating offshore wind turbines (FOWTs) is challenging due to the complexities associated with simultaneous application of two different scaling laws, governing the hydrodynamic and aerodynamic loading on the structure. To avoid these issues, this paper presents a real-time hybrid testing strategy in which a feedback-loop, consisting of an on-board fan, and control algorithm, is utilised to emulate the aerodynamic forces acting on the FOWT system. Here, we apply this strategy to a 70th-scale IEA Wind 15MW reference wind turbine mounted on a version of the VolturnUS-S platform. Unlike other similar methods, which directly simulate the aerodynamic …

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Teleporting Into Walls? The Irrelevance Of The Physical World In Embodied Perspective-Taking, Sarah Salo, Steven Samuel Dec 2022

Teleporting Into Walls? The Irrelevance Of The Physical World In Embodied Perspective-Taking, Sarah Salo, Steven Samuel

School of Psychology

No abstract provided.

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Eye Closure Interacts With Music To Influence Vividness And Content Of Directed Imagery, Steffen A. Herff, Sophie Mcconnell, Julie L. Ji, Jon B. Prince Dec 2022

Eye Closure Interacts With Music To Influence Vividness And Content Of Directed Imagery, Steffen A. Herff, Sophie Mcconnell, Julie L. Ji, Jon B. Prince

School of Psychology

Goal-directed, intentional mental imagery generation supports a range of daily self-regulatory activities, such as planning, decision-making, and recreational escapism. Many clinical interventions for mood and anxiety disorders also use imagery and their effectiveness can be affected by an individual's ability to manipulate vividness and content of mental imagery. Prior literature points towards music as a promising candidate to influence imagination in such settings, but basic questions remain regarding how music affects mental imagery and how it interacts with basic, well-established parameters, such as facilitatory effects of eye closure. One hundred participants listened to music and a silent control whilst performing …

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‘Making Up For Lost Time’: Neoliberal Governance And Educational Catch-Up Measures For Disadvantaged Students During The Covid-19 Pandemic, B Gross, P Kelly, S Hofbauer Dec 2022

‘Making Up For Lost Time’: Neoliberal Governance And Educational Catch-Up Measures For Disadvantaged Students During The Covid-19 Pandemic, B Gross, P Kelly, S Hofbauer

Plymouth Institute of Education

The neoliberal governance of education and the import of values such as economic productivity are changing schools in Europe to different degrees. Understanding the effects of this on disadvantaged students is especially critical during and after the COVID-19 pandemic, given their greater need for catch-up support. In this paper we analyse national government policy guidelines and reports concerning catch-up measures in Italy, Germany and England and illuminate debates between various actors using news and education media reports. We find that while catch-up measures in the studied countries promote equality of access, for instance through extending schooling to make up for …

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Study Protocol For First Dental Steps Intervention: Feasibility Study Of A Health Visitor Led Infant Oral Health Improvement Programme, Patricia N. Albers, Joanna G. Williams, Sarab El-Yousfi, Zoe Marshman, Reena Patel, Rebecca Kandiyali, Katie Breheny, Vocht F De, Chris Metcalfe, Robert Witton, Ruth Kipping Dec 2022

Study Protocol For First Dental Steps Intervention: Feasibility Study Of A Health Visitor Led Infant Oral Health Improvement Programme, Patricia N. Albers, Joanna G. Williams, Sarab El-Yousfi, Zoe Marshman, Reena Patel, Rebecca Kandiyali, Katie Breheny, Vocht F De, Chris Metcalfe, Robert Witton, Ruth Kipping

Peninsula Dental School

Abstract Background Dental caries in childhood is a burden on the daily lives of children and their families, and associated with poor oral health in adulthood. In England, dental caries is the most common reason for young children to be admitted to hospital. It is believed that most tooth extractions (due to decay) for children aged 10 years and under, could be avoided with improved prevention and early management. National public health policy recommendations in England include specific oral health initiatives to tackle tooth decay. One of these initiatives is delivered as part of the Healthy Child Programme and includes …

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Factors Influencing The State Of Blinds And Lights In Primary Schools: Behavioural Models And Opportunities To Improve Children's Visual Environment, Ss Korsavi, Rv Jones, A Fuertes Dec 2022

Factors Influencing The State Of Blinds And Lights In Primary Schools: Behavioural Models And Opportunities To Improve Children's Visual Environment, Ss Korsavi, Rv Jones, A Fuertes

School of Art, Design and Architecture

The state of blinds and lights affects children's visual environment and comfort, however, there is a significant gap in research on the factors leading to the operation of blinds and lights in primary school classrooms. This study identifies and categorises the main drivers of operations on blinds and lights and investigates optimal light levels for children in primary schools. The study collected measurements of environmental variables, observations of operations on blinds and lights using forms and time-lapse cameras and visual sensation questionnaires in 31 naturally ventilated classrooms in the UK for one year. Results suggest that operations on blinds and …

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Verbal Lie Detection: Its Past, Present And Future, Aldert Vrij, Pär Anders Granhag, Tzachi Ashkenazi, Giorgio Ganis, Sharon Leal, Ronald P. Fisher Dec 2022

Verbal Lie Detection: Its Past, Present And Future, Aldert Vrij, Pär Anders Granhag, Tzachi Ashkenazi, Giorgio Ganis, Sharon Leal, Ronald P. Fisher

School of Psychology

This article provides an overview of verbal lie detection research. This type of research began in the 1970s with examining the relationship between deception and specific words. We briefly review this initial research. In the late 1980s, Criteria-Based Content Analysis (CBCA) emerged, a veracity assessment tool containing a list of verbal criteria. This was followed by Reality Monitoring (RM) and Scientific Content Analysis (SCAN), two other veracity assessment tools that contain lists of verbal criteria. We discuss their contents, theoretical rationales, and ability to identify truths and lies. We also discuss similarities and differences between CBCA, RM, and SCAN. In …

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Plastic Pollution Requires An Integrative Systems Approach To Understand And Mitigate Risk, Winnie Courtene-Jones, Nathaniel J. Clark, Richard C. Thompson Dec 2022

Plastic Pollution Requires An Integrative Systems Approach To Understand And Mitigate Risk, Winnie Courtene-Jones, Nathaniel J. Clark, Richard C. Thompson

School of Biological and Marine Sciences

To date, much effort has been placed on quantifying plastic pollution and understanding its negative environmental effects, arguably to the detriment of research and evaluation of potential interventions. This has led to piecemeal progress in interventions to reduce plastic pollution, which do not correspond to the pace of emissions. For substances that are used on a global scale and identified as hazardous, there is a need to act before irreversible damage is done. For example, the history of dichlorodiphenyltrichloethane's (DDT) use has demonstrated that legacy chemicals with properties of persistence can still be found in the environment despite being first …

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Disruption Of Marine Habitats By Artificial Light At Night From Global Coastal Megacities, T. W. Davies, T. J. Smyth, A. E. Wright, A. Edwards-Jones, A Queiros, O. Rendon, S. Tidau, D. Mckee Dec 2022

Disruption Of Marine Habitats By Artificial Light At Night From Global Coastal Megacities, T. W. Davies, T. J. Smyth, A. E. Wright, A. Edwards-Jones, A Queiros, O. Rendon, S. Tidau, D. Mckee

School of Biological and Marine Sciences

Half of globally significant megacities are situated near the coast, exposing urban marine ecosystems to multiple stressors such as waste-water discharge containing a host of organic and inorganic pollutants, air and noise pollution. In addition to these well recognized sources, artificial light at night (ALAN) pollution is inseparable from cities but poorly quantified in marine ecosystems to date. We have developed a time- and wavelength-resolving hydrological optical model that includes solar (daylight and twilight components), lunar and ALAN source terms and propagates these spectrally through a tidally varying water column using Beer’s Law. Our model shows that for 8 globally …

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Neural Network Detection Of Pacemakers For Mri Safety, M Thurston, H Wit, D Kim Dec 2022

Neural Network Detection Of Pacemakers For Mri Safety, M Thurston, H Wit, D Kim

Peninsula Medical School

Flagging the presence of cardiac devices such as pacemakers before an MRI scan is essential to allow appropriate safety checks. We assess the accuracy with which a machine learning model can classify the presence or absence of a pacemaker on pre-existing chest radiographs. A total of 7973 chest radiographs were collected, 3996 with pacemakers visible and 3977 without. Images were identified from information available on the radiology information system (RIS) and correlated with report text. Manual review of images by two board certified radiologists was performed to ensure correct labeling. The data set was divided into training, validation, and a …

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Novel Dnm1l Variants Impair Mitochondrial Dynamics Through Divergent Mechanisms, Jdc Pereira Baptista Dec 2022

Novel Dnm1l Variants Impair Mitochondrial Dynamics Through Divergent Mechanisms, Jdc Pereira Baptista

Peninsula Medical School

Imbalances in mitochondrial and peroxisomal dynamics are associated with a spectrum of human neurological disorders. Mitochondrial and peroxisomal fission both involve dynamin-related protein 1 (DRP1) oligomerisation and membrane constriction, although the precise biophysical mechanisms by which distinct DRP1 variants affect the assembly and activity of different DRP1 domains remains largely unexplored. We analysed four unreported de novo heterozygous variants in the dynamin-1-like gene DNM1L, affecting different highly conserved DRP1 domains, leading to developmental delay, seizures, hypotonia, and/or rare cardiac complications in infancy. Single-nucleotide DRP1 stalk domain variants were found to correlate with more severe clinical phenotypes, with in vitro recombinant …

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