Digital Commons Network^™

Site-Level Variation In The Characteristics And Care Of Infants With Neonatal Opioid Withdrawal, Leslie W. Young, Zhuopei Hu, Robert D. Annett, Abhik Das, Janell F. Fuller, Rosemary D. Higgins, Barry M. Lester, Stephanie L. Merhar, Alan E. Simon, Songthip Ounpraseuth, P Brian Smith, Margaret M. Crawford, Andrew M. Atz, Lesley E. Cottrell, Adam J. Czynski, Sarah Newman, David A. Paul, Pablo J. Sánchez, Erin O. Semmens, M Cody Smith, Christine B. Turley, Bonny L. Whalen, Brenda B. Poindexter, Jessica N. Snowden, Lori A. Devlin, Eunice Kennedy Shriver National Institute Of Child Health And Human Development Neonatal Research Network And The Nih Environmental Influences On Child Health Outcomes (Echo) Program Institutional Development Awards States Pediatric Clinical Trials Network

Pediatrics Research and Scholarship

BACKGROUND AND OBJECTIVES: Variation in pediatric medical care is common and contributes to differences in patient outcomes. Site-to-site variation in the characteristics and care of infants with neonatal opioid withdrawal syndrome (NOWS) has yet to be quantified. Our objective was to describe site-to-site variation in maternal-infant characteristics, infant management, and outcomes for infants with NOWS.

METHODS: Cross-sectional study of 1377 infants born between July 1, 2016, and June 30, 2017, who were ≥36 weeks' gestation, with NOWS (evidence of opioid exposure and NOWS scoring within the first 120 hours of life) born at or transferred to 1 of 30 participating …

In-Hospital Postoperative Mortality Rates For Selected Procedures In Tanzania's Lake Zone., Taylor Wurdeman, Christopher Strader, Shehnaz Alidina, David Barash, Isabelle Citron, Ntuli Kapologwe, Erastus Maina, Fabian Massaga, Adelina Mazhiqi, John G. Meara, Gopal Menon, Cheri Reynolds, Meaghan Sydlowski, John Varallo, Sarah Maongezi, Mpoki Ulisubisya

Project ECHO Bibliography

BACKGROUND: Postoperative mortality rate is one of six surgical indicators identified by the Lancet Commission on Global Surgery for monitoring access to high-quality surgical care. The primary aim of this study was to measure the postoperative mortality rate in Tanzania's Lake Zone to provide a baseline for surgical strengthening efforts. The secondary aim was to measure the effect of Safe Surgery 2020, a multi-component intervention to improve surgical quality, on postoperative mortality after 10 months.

METHODS: We prospectively collected data on postoperative mortality from 20 health centers, district hospitals, and regional hospitals in Tanzania's Lake Zone over two time periods: …

Medical Nutrition Therapy Access In Ckd: A Cross-Sectional Survey Of Patients And Providers, Elizabeth Yakes Jimenez, Kathryn Kelley, Marsha Schofield, Deborah Brommage, Alison Steiber, Jenica K. Abram, Holly Kramer

Pediatrics Research and Scholarship

RATIONALE & OBJECTIVE: Nutrition management can slow the progression of chronic kidney disease (CKD) and help manage complications of CKD, but few individuals with CKD receive medical nutrition therapy before initiating dialysis. This study aimed to identify knowledge, attitudes, experiences, and practices regarding medical nutrition therapy and barriers and facilitators to medical nutrition therapy access for individuals with CKD stages G1-G5 from the perspective of patients and providers.

STUDY DESIGN: Cross-sectional study composed of anonymous surveys.

SETTING & POPULATION: Adults with CKD stages G1-G5 and medical providers and registered dietitian nutritionists who regularly see patients with CKD stages G1-G5 were …

Capacity Building For A New Multicenter Network Within The Echo Idea States Pediatric Clinical Trials Network, Robert D. Annett, Scott Bickel, John C. Carlson, Kelly Cowan, Sara Cox, Mark J. Fisher, J Dean Jarvis, Alberta S. Kong, Jessica S. Kosut, Kurtis R. Kulbeth, Abbot Laptook, Pearl A. Mcelfish, Mary M. Mcnally, Lee M. Pachter, Barbara A. Pahud, Lee A. Pyles, Jennifer Shaw, Kari Simonsen, Jessica Snowden, Christine B. Turley, Andrew M. Atz

Pediatrics Research and Scholarship

No abstract provided.

Vacteens.Org: A Mobile Web App To Improve Hpv Vaccine Uptake, W Gill Woodall, Gregory Zimet, Alberta Kong, David Buller, Jeannyfer Reither, Lance Chilton, Valerie Myers, Randall Starling

Pediatrics Research and Scholarship

U.S. HPV vaccine uptake remains below the Healthy People 2030 goal of 80% series completion. Parental concerns and misinformation about the efficacy and safety of the Human Papillomavirus (HPV) vaccine remain, and may be addressed by digital interventions tailored to their concerns. Reported here are results from a small scale randomized trial testing a mobile web app for parents and their adolescent daughters (ages 11-14 years) encouraging HPV vaccination in New Mexico, an ethnically-diverse U.S. state.

Metabolic Reprogramming And Cell Adhesion In Acute Leukemia Adaptation To The Cns Niche, Nitesh D. Sharma, Esra'a Keewan, Ksenia Matlawska-Wasowska

Pediatrics Research and Scholarship

Involvement of the Central Nervous System (CNS) in acute leukemia confers poor prognosis and lower overall survival. Existing CNS-directed therapies are associated with a significant risk of short- or long-term toxicities. Leukemic cells can metabolically adapt and survive in the microenvironment of the CNS. The supporting role of the CNS microenvironment in leukemia progression and dissemination has not received sufficient attention. Understanding the mechanism by which leukemic cells survive in the nutrient-poor and oxygen-deprived CNS microenvironment will lead to the development of more specific and less toxic therapies. Here, we review the current literature regarding the roles of metabolic reprogramming …

Spreading Depolarization After Chronic Subdural Hematoma Evacuation: Associated Clinical Risk Factors And Influence On Clinical Outcome, Christine Medows, Herbert Davis, Laila Mohammad, C William Shuttleworth, Michel Torbey, Yiliang Zhu, Ali A. Alsahara, Andrew P. Carlson

Brain & Behavioral Health Research Day

Background: Chronic subdural hematoma (cSDH) is a common neurosurgical condition responsible for excess morbidity, particularly in the geriatric population. Recovery after evacuation is complicated by fluctuating neurological deficits in a high proportion of patients. We previously demonstrated that spreading depolarizations (SD) may be responsible for some of these events. In this study, we aim to determine candidate risk factors for probable SD and assess the influence of probable SD on outcome.

Methods:We used two cohorts who underwent surgery for cSDH. The first cohort (n=40) had electrocorticographic (ECoG) monitoring to detect SD. In the second cohort (n=345), we retrospectively identified …

Physical Activity Newsletter English - Module 2, Unm Prevention Research Center

Module 2 Family Engagement Activities

Physical Activity Newsletter English - Module 2

Unm Pathology Pathfinder Winter 2021, Unm Department Of Pathology

Newsletters

No abstract provided.

Impact Of A Multidisciplinary Workflow On Safety And Management Of Patients With Heparin-Induced Thrombocytopenia, Sheh-Li Chen, Andrew P. Stivers, Jonathan D. Cicci, Tanner L. Hedrick, Marian A. Rollins-Raval, Raj S. Kasthuri, Kalynn A. Northam

Pathology Research and Scholarship

PURPOSE: Heparin-induced thrombocytopenia (HIT) is a serious complication of heparin administration. Management strategies are complex and include discontinuing heparin products, initiating alternative anticoagulants, interpreting laboratory test results, documenting heparin allergies, and providing patient education. Medication error reports and a retrospective review conducted at an academic medical center revealed an opportunity for a quality improvement initiative and led to the creation of a multidisciplinary workflow for the management of HIT. In a pre-post study, the impact of the multidisciplinary workflow on the safety and management of HIT was evaluated.

METHODS: The preimplementation group consisted of adult patients tested for suspected HIT …

Post-Discharge Healthcare Utilization In Infants With Neonatal Opioid Withdrawal Syndrome, Shikhar Shrestha, Melissa H. Roberts, Jessie R. Maxwell, Lawrence M. Leeman, Ludmila N. Bakhireva

Family and Community Medicine Research and Scholarship

The opioid epidemic in the United States has led to a significant increase in the incidence of neonatal opioid withdrawal syndrome (NOWS); however, the understanding of long-term consequences of NOWS is limited. The objective of this study was to evaluate post-discharge healthcare utilization in infants with NOWS and examine the association between NOWS severity and healthcare utilization. A retrospective cohort design was used to ascertain healthcare utilization in the first year after birth-related discharge using the CERNER Health Facts® database. ICD-9/ICD-10 diagnostic codes were used to identify live births and to classify infants into two study groups: NOWS and uncomplicated …

Biomedical Informatics Seminar Series (Biomiss) 2021, Jonathan Eldredge, Gale Hannigan, Tamara Wheeler

Biomedical Informatics Seminar Series (BioMISS)

No abstract provided.

The Role Of Lawyers In Bridging The Gap Between The Robust Federal Rights To Education And Relatively Low Education Outcomes In Guatemala, Maryam Ahranjani

Faculty Scholarship

Relative to other countries in the world and in Central America, the Guatemalan Constitution and the federal education law include a robust and detailed right to education. However, literacy rates and secondary educational attainment, particularly for Indigenous people and young women living in rural communities, remain low. The COVID-19 pandemic has only exacerbated disparities. Once children return to schools after the pandemic, the gaps will be even larger. Lawyers can play a critical role in making the strong Constitutional right to education more meaningful.

Effect Of Dexpramipexole On Neuropathic Pain In Prenatal Alcohol Exposed Male And Female Subjects, Justine Zimmerly, Andrea Pasmay, Shahani Noor, Annette Fernandez, Melody Sun, Suzy Davies, Daniel Savage, Nikolaos Mellios, Erin Milligan

Brain & Behavioral Health Research Day

Prenatal alcohol exposure (PAE) results in chronic central nervous system (CNS) deficits and heightened neuroimmune responses that persist into adulthood. Young adult animals with moderate PAE display pathological sensitivity to light touch, referred to as allodynia, following sciatic nerve chronic constriction injury (CCI). Allodynia coincides with activated spinal glia and an increased presence of peripheral immune cells that invade the CNS. Activated glia and immune cells release the potent pro-inflammatory cytokine, interleukin-1 (IL-1β). Previous studies have shown that dexpramipexole, an enantiomer of pramipexole, reduces caspase-3 and cell death, suggesting a possible anti-inflammatory action. The current study explored whether dexpramipexole is …

Extracellular Asc Level As A Potential Biomarker For Alzheimer’S Disease, Qi "Phoebe" Dong, Shanya Jiang, Kathryn Sanchez, Gary Rosenberg, Kiran Bhaskar

Brain & Behavioral Health Research Day

Purpose:

There is mounting evidence of a link between pathological tau (p-tau) and neuroinflammation in neurodegenerative diseases including Alzheimer’s Disease (AD). In previous studies, we found that p-tau can induce neuroinflammation through activating inflammasomes, a multi-protein complex that recognizes danger signals including bacterial toxins lipopolysaccharide (LPS), nigericin and endogenous danger signals including extracellular ATP and p-tau. Activation of inflammasomes leads to maturation of pro-inflammatory cytokines interleukin-1 (IL)-1b and IL-18, causing neuroinflammation. We aim to obtain quantitative measurements of activated inflammasomes, specifically the levels of assembled ASC (apoptosis-associated speck-like protein containing a CARD), a key adaptor protein of inflammasomes, in the …

Frailty Status But Not Age Predicts Surgical Outcomes In Spinal Tumors: An Nsqip 2015-19 Analysis Of 4662 Patients, Syed Faraz Kazim, Christian A. Bowers, Chad D. Cole, Rohini N. Mckee, Meic H. Schmidt

Brain & Behavioral Health Research Day

Introduction

The preoperative risk stratification of patients undergoing spinal tumor resection remains challenging. In recent years, the efforts to look beyond age alone as an outcomes predictor has resulted in the development of measures of physiological reserve (or ‘frailty indices’). The most frequently cited index in spine surgery is the modified frailty index [11-point (mFI-11) or 5-point (mFI-5)]. The present study was performed to evaluate effect of frailty (as measured by mFI-5) versus age on surgical outcomes of spinal tumors in a large national registry.

Methods

The National Surgical Quality Improvement Program (NSQIP) database was used to collect data for …

Cognitive Impairment After Intracerebral Hemorrhage: A Systematic Review And Meta-Analysis, Syed Faraz Kazim, Jonathan V. Ogulnick, Myranda B. Robinson, Javed Khader Eliyas, Benjamin Q. Spangler, Tyler J. Hough, Erick Martinez, Zafar Karimov, Devan W. Vidrine, Meic H. Schmidt, Christian A. Bowers

Brain & Behavioral Health Research Day

Introduction

Spontaneous, non-traumatic intracerebral hemorrhage (ICH) refers to bleeding within the brain parenchyma that occurs in the absence of trauma and carries significant morbidity and mortality. While a close association has been identified between stroke and dementia, available literature primarily focuses on post-stroke dementia in ischemic stroke patients, and there are few clinical studies evaluating cognitive dysfunction post-ICH. The present systematic review and meta- analysis analyzes the available clinical literature on post-ICH cognitive impairment.

Methods

We conducted a systematic review with meta-analysis following PRISMA guidelines. A search of bibliographic databases up to July 31, 2020 yielded a total of 2155 …

Characteristics Of Hispanics Referred To Coordinated Specialty Care For First-Episode Psychosis And Factors Associated With Enrollment, Bess Rose Friedman, Danielle K. Durán, Anastasiya Nestsiarovich, Mauricio Tohen, Rhoshel K. Lenroot, Juan R. Bustillo, Annette S. Crisanti

Brain & Behavioral Health Research Day

Objective: The primary objectives of this study were to examine referral sources and demographic, clinical, and socioenvironmental characteristics of Hispanics referred to and enrolled in a program of coordinated specialty care (Early CSC program) for first-episode psychosis, to compare them with characteristics of other referred and enrolled racial-ethnic groups, and to identify factors associated with enrollment in the program .

Methods: A retrospective review was conducted for all individuals referred to and enrolled in the Early CSC program over a 2-year period. Extracted data included referral sources and demographic and clinical characteristics. Zip code–level data from publicly available sources were …

Loss Of Neurodevelopmental Transcription Factors In Glioblastoma Leads To Decreased Progression And Proliferation And Increased Survival, Bianca L. Myers, Matthew Keith, Rebekkah Anderson, Tou Yia Vue

Brain & Behavioral Health Research Day

Glioblastoma (GBM) makes up about 50% of primary brain tumors and survival has not increased over the last 30 years, with less than 5% of patients surviving past 5 years of diagnosis. The lethality of GBM is likely due to high degree of inter- and intratumoral heterogeneity and the presence of key neurodevelopmental transcription factors such as ASCL1 and OLIG2, which have been shown to be present in the majority of GBMs. Functionally, these basic-helix-loop-helix (bHLH) transcription factors form heterodimers with E-proteins (E47/TCF4) and bind to DNA to regulate gene transcription. Previously, we showed that ASCL1 binds to promoter and …

Parkinson’S Disease Patients With Hallucinations Exhibit Dopaminergic Degeneration And Cortical Thinning, Ann Horner, Christopher J. Wertz, Nicholas Shaff, Alexandra P. Hartman, Andrew R. Mayer, Andrei A. Vakhtin, Amanda Deligtisch, Sarah Pirio Richardson, Sephira G. Ryman

Brain & Behavioral Health Research Day

Objective

Examine whether Parkinson’s disease patients (PD) who experience hallucinations (PD+hall) exhibit a greater decline in striatal dopamine and corresponding posterior cortical decline relative to PD patients without hallucinations (PD-ctrl).

Background

The development of visual hallucinations in PD is a significant predictor of dementia and earlier nursing home placement[1]. A reduction in striatal dopamine transporter has independently been linked to posterior cortical atrophy[2] and psychosis[3], [4].

Methods

This study used data from a cohort of de novo PD patients and healthy controls (HC) enrolled in the Parkinson’s Progression Markers Initiative. We extracted longitudinal cortical thickness values from T1-weighted structural MRI …

The Reward Positivity Is Enhanced In Individuals With Alcohol Use Disorder, Garima Singh, Ethan Campbell, Jeremy Hogeveen, Katie Witkiewitz, Eric Claus, James Cavanagh

Brain & Behavioral Health Research Day

The EEG feature known as the Reward Positivity (RewP) is known to reflect a combination of the surprise and affective value of reward feedback. Here we investigated if individuals with Alcohol Use Disorder had an enhanced RewP to alcohol stimuli used as rewarding feedback, suggesting a mechanism for linking biased attention with reward integration for addiction-specific stimuli. Community participants aged 18-55 years are being recruited and demographically matched across the two groups: AUD (AUDIT>5) and Control (AUDIT<3). Participants completed a reinforcement learning task with affective stimuli as feedback while EEG was recorded. A 2*2 ANOVA was conducted to examine how affective image (puppies vs. alcohol) and group (AUD, CTL) influenced RewP amplitude. Preliminary results suggest that a main effect of group (p=.104) although there was no effect of affective imagery (p=.157) nor an interaction (p=.637). Overall, the findings suggest that AUD have larger reward positivity, but it does not appear to be modulated by alcohol conditions.

Live Imaging Of Brain Network Dynamics In An Acute Threat Response By Memri: Effects Of Early Life Adversity On Noradrenergic System Anatomy, Taylor W. Uselman, Russell E. Jacobs, Elaine L. Bearer

Brain & Behavioral Health Research Day

Monoaminergic signaling in cortical-limbic circuits regulate both normal physiology and responses to stress. Indeed, monoaminergic reuptake transporters, located on the pre-synaptic terminals of distal projections, are common pharmacological targets for mental disorders, like anxiety and depression. Early life adversity (ELA), which has an interaction with monoaminergic systems, increases vulnerability to mental disorders later in life. Despite this, we are yet to understand how ELA alters brain-wide patterns of neural activity. Here, we combine Manganese-enhanced MRI (MEMRI) with behavioral tracking and immunohistochemistry to investigate the effects of ELA on the modular neuroarchitecture and behavioral response to acute threat. ELA was administered …

Proteopathic Tau Primes And Activates Interleukin-1ss (Il-1ss) Via Myd88- And Nlrp3-Asc-Inflammasome Dependent Pathways Cell-Autonomous To Microglia, Shanya Jiang, Nicole M. Maphis, Jessica Binder, Devon Chisholm, Lea Weston, Walter Duran, Crina Floruta, Amber Zimmerman, Michael Mandell, Stephen Jett, Eileen Bigio, Changiz Geula, Nikolaos Mellios, Jason Weick, Eicke Latz, Michael Heneka, Kiran Bhaskar

Brain & Behavioral Health Research Day

Pathological hyperphosphorylation and aggregation of tau (pTau) and neuroinflammation, driven by interleukin-1β (IL-1β), are the major hallmarks of tauopathies. Here, we show that pTau primes and activates IL-1ß. First, pTau burden co-exist with elevated IL-1β and inflammasome proteins (NLRP3 and ASC) in autopsy brains of human tauopathies. Suppression of human tau blocks both priming and activation of ASC and NLRP3 in the rTg4510 mouse model of tauopathy. Treating microglia with pTau-containing neuronal media, exosomes or purified human tau tangles causes IL-1β activation, which is NLRP3, ASC, and caspase-1-dependent.

While the microglia-restricted deletion of a common innate immune adaptor protein, MyD88 …

Non-Invasive Vagus Nerve Stimulation (Nvns) Reduced Neuron-Derived Il-1Β And Neuroinflammation In Acute Ischemic Rat Brain, Lisa Y. Yang, Bruce Simon, Yi Yang

Brain & Behavioral Health Research Day

We previously demonstrated that treatment with nVNS during middle cerebral artery occlusion (MCAO) reduces infarct volume and BBB disruption. Although nVNS was suggested to play its neuroprotective role by initiating a splenic-sympathetic-nerve anti- inflammatory pathway, human study showed that nVNS could directly regulate the activity of brain regions within MCA territories through VN central project. While studying the mechanism of the neuroprotective role of nVNS, we observed that ischemic neurons, rather than active microglia, are the main resource of interleukin-1 (IL-1), pro- inflammatory cytokine, 24-hour after stroke. This study tested the novel hypothesis that nVNS reduced neuron-derived IL-1 and neuroinflammation …

Circhomer1 Has Biomarker Potential For Cortical Dysfunction In Psychiatric Disease, Amber Zimmerman, Alexander Hafez, Jason P. Weick, Nora Perrone-Bizzozero, Nikolaos Mellios, Jonathan Brigman

Brain & Behavioral Health Research Day

Circular RNAs (circRNAs) are an emerging class of long non-coding RNAs with complex regulatory potential that can impact gene expression and function. However, the vast majority of circRNAs have not been characterized and little is known about their function in the brain despite their abundance in cortical tissue. Recent work has focused on circRNAs as biomarkers for disease and therapeutics due to their increased stability since their biogenesis through backsplicing renders them resistant to RNA degradation. CircRNAs are developmentally regulated and differentially regulated in brain disorders including Alzheimer’s Disease (AD) and schizophrenia (SCZ). While plasticity-related protein-coding genes have been associated …

The Impact Of Drought On Agriculture In New Mexico, Savannah P. Rodriguez

Climate Change and Public Health Preparedness

No abstract provided.

Ensuring Optimal Community Hiv Testing Services In Nigeria Using An Enhanced Community Case-Finding Package (Eccp), October 2019-March 2020: Acceleration To Hiv Epidemic Control., Ibrahim Jahun, Emilio Dirlikov, Solomon Odafe, Aminu Yakubu, Andrew T Boyd, Pamela Bachanas, Charles Nzelu, Gambo Aliyu, Tedd Ellerbrock, Mahesh Swaminathan

Project ECHO Bibliography

Purpose: The 2018 Nigeria HIV/AIDS Indicator and Impact Survey (NAIIS) showed Nigeria's progress toward the UNAIDS 90-90-90 targets: 47% of HIV-positive individuals knew their status; of these, 96% were receiving antiretroviral therapy (ART); and of these, 81% were virally suppressed. To improve identification of HIV-positive individuals, Nigeria developed an Enhanced Community Case-Finding Package (ECCP). We describe ECCP implementation in nine states and assess its effect.

Methods: ECCP included four core strategies (small area estimation [SAE] of people living with HIV [PLHIV], map of HIV-positive patients by residence, HIV risk-screening tool [HRST], and index testing [IT]) and four supportive strategies (alternative …

A Quality Improvement Learning Collaborative For Human Papillomavirus Vaccination., Kristin Oliver, Kera Beskin, Laura Noonan, Amy Shah, Rebecca Perkins, Sharon Humiston

Project ECHO Bibliography

Many published accounts have shown that quality improvement (QI) initiatives within medical practice settings can increase vaccination rates. Project ECHO is a telementoring platform that uses video conferencing technology to educate and support healthcare professionals through case-based learning and brief lectures. This manuscript explores the results of a learning collaborative focused on combining QI and Project ECHO to increase human papillomavirus (HPV) vaccination rates within pediatric practices.

Methods: The American Academy of Pediatrics (AAP) recruited 3 AAP chapters that then recruited individual pediatricians and their practices for participation. Participants responded to surveys regarding chapter and pediatrician experience and satisfaction. Impact …

Enhancing Validity Of Readiness To Change Measures: Experimental Manipulation Of Cognitive Effort, Jude G. Chavez, Frank J. Schwebel, Matthew R. Pearson

Brain & Behavioral Health Research Day

Based on the Transtheoretical Model, we expect readiness to change (RTC) to be predictive of actual substance-related behavior change, though this relationship is surprisingly modest. We assert that standard assessments of RTC do not require sufficient cognitive effort to obtain an accurate assessment. We expected that RTC scores are inflated (i.e., overestimated) under standard self-report conditions. To test this hypothesis, we compared RTC scores across three conditions: 1) standard low effort condition, 2) medium effort condition (had to select likes/dislikes of substance use, and negative consequences of changing one’s use), and 3) high effort condition (also provided text responses to …

Interactions Between Autophagy, Herpesvirus And Neurodegeneration In Alzheimer’S Disease, Amir Nafchi, Mohammad Anani, Tudor Oprea, Ben Readhead, Elaine Bearer

Brain & Behavioral Health Research Day

Introduction: Various microbes and viruses have been associated with the pathogenesis of Alzheimer’s Diseases (AD), with many studies dating back to the 1950s. There are challenges in establishing direct links between the microbes and AD pathology. Since microbes and viruses have been observed to be dormant and reactivate in aging brains, it is not clear if the microbes are a byproduct of AD pathology or a direct cause of it. Recently, various publications considered the link between several herpes simplex viruses and neurodegeneration in AD. For example, Readhead et al. utilized multiomics data from post-mortem brain samples meeting the neuropathological …