Digital Commons Network^™

Mucosal Immune System Of African Lungfish, Ryan D. Heimroth

Biology ETDs

Conquering land was an apex moment in the evolution of vertebrates. Physiologically, the first vertebrates to transition to life on land had to adapt in order to survive in an oxygen-rich environment where gravitational forces and limited water prevailed. Several extant vertebrates including anurans and lungfish, survive droughts by undergoing aestivation. Unfavorable environmental conditions trigger lungfish to aestivate. Aestivation is a process of metabolic torpor wherein the fish will encase itself in a mucus cocoon and not move until favorable environmental conditions (food and water) are reintroduced. Aestivation can be reproduced in laboratory settings and, thus, lungfish can be used …

Therapeutic Plasma Exchange And Intravenous Immune Globulin In The Treatment Of Heparin-Induced Thrombocytopenia: A Systematic Review, Chinonso Onuoha, Karen D. Barton, Edward C C Wong, Jay S. Raval, Marian A. Rollins-Raval, Tina A. Ipe, Joseph E. Kiss, Leonard I. Boral, Jill Adamksi, Nicole D. Zantek, Oluwatoyosi A. Onwuemene

Pathology Research and Scholarship

BACKGROUND: Immunomodulatory strategies in heparin-induced thrombocytopenia (HIT) include the use of intravenous immune globulin (IVIG) and therapeutic plasma exchange (TPE). The optimal application of these therapies is unknown and outcomes data are limited. We investigated treatment categories and laboratory and clinical outcomes of IVIG and/or TPE in HIT with a systematic literature review.

STUDY DESIGN AND METHODS: We searched MEDLINE, Embase, and Web of Science through December 2019 for studies combining controlled vocabulary and keywords related to thrombocytopenia, heparin, TPE, and IVIG. The primary outcome was treatment indication. Secondary outcomes were platelet recovery, HIT laboratory parameters, heparin re-exposure, and post-treatment …

Counter-Mapping As Display: Unfolding, Revealing, And Concealing Intermediary Spaces, Larson Ellen

Hemisphere: Visual Cultures of the Americas

No abstract provided.

(Review) Indelible Ink: Native Women, Printmaking, Collaboration, Presented At The University Of New Mexico Art Museum, David Saiz, Paloma Barraza

Hemisphere: Visual Cultures of the Americas

No abstract provided.

Effects Of Closed Loop Transcranial Alternating Current Stimulation Targeting Slow Oscillation Sleep On Post-Sleep Object Location Learning, Bradley M. Robert

Psychology ETDs

Modulating sleep architecture to augment memory performance can provide valuable insight into how sleep contributes to memory. Slow wave activity has been identified as an important contributor to sleeps impact on memory. While the beneficial role of SWS in offline consolidation is well established research investigating SWS’s role in post-sleep memory formation is limited. Here we investigated the relationship between SWS and post-sleep learning by modulating slow wave oscillations (SWO) with closed loop transcranial alternating current stimulation (tACS) with an aim toward enhancing learning capacity for object location associations. Thirty-six subjects were randomly assigned to either sham (21) or verum …

Pyrazole-Based Lactate Dehydrogenase Inhibitors With Optimized Cell Activity And Pharmacokinetic Properties, Ganesha Rai, Daniel J. Urban, Bryan T. Mott, Xin Hu, Shyh-Ming Yang, Gloria A. Benavides, Michelle S. Johnson, Giuseppe L. Squadrito, Kyle R. Brimacombe, Tobie D. Lee, Dorian M. Cheff, Hu Zhu, Mark J. Henderson, Katherine Pohida, Gary A. Sulikowski, David M. Dranow, Md Kabir, Pranav Shah, Elias Padilha, Dingyin Tao, Yuhong Fang, Plamen P. Christov, Kwangho Kim, Somnath Jana, Pavan Muttil, Tamara Anderson, Nitesh K Kunda, Helen J. Hathaway, Donna F. Kusewitt, Nobu Oshima, Murali Cherukuri, Douglas R. Davies, Jeffrey P. Norenberg, Larry A. Sklar, William J. Moore, Chi V Dang, Gordon M. Stott, Leonard Neckers, Andrew J. Flint, Victor M. Darley-Usmar, Anton Simeonov, Alex G. Waterson, Ajit Jadhav, Matthew D. Hall, David J. Maloney

Pathology Research and Scholarship

Lactate dehydrogenase (LDH) catalyzes the conversion of pyruvate to lactate, with concomitant oxidation of reduced nicotinamide adenine dinucleotide as the final step in the glycolytic pathway. Glycolysis plays an important role in the metabolic plasticity of cancer cells and has long been recognized as a potential therapeutic target. Thus, potent, selective inhibitors of LDH represent an attractive therapeutic approach. However, to date, pharmacological agents have failed to achieve significant target engagement in vivo, possibly because the protein is present in cells at very high concentrations. We report herein a lead optimization campaign focused on a pyrazole-based series of compounds, …

Ms4 Swmpp 2020, National Technology & Engineering Solutions Of Sandia, Llc (Ntess) And Department Of Energy (Doe)

Municipal Separate Storm Sewer System (MS4) Permit

Stormwater discharges from industrial activities at Sandia National Laboratories/New Mexico (SNL/NM) are eligible for coverage under the National Pollutant Discharge Elimination System (NPDES) Multi-Sector General Permit (MSGP). This Stormwater Pollution Prevention Plan (SWPPP) was prepared by National Technology and Engineering Solutions of Sandia (NTESS) for the Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia Field Office (SFO), owner of SNL/NM, located in Albuquerque, NM. This SWPPP was prepared in compliance with the 2015 MSGP (effective June 4, 2015) and includes a description, potential pollutant sources, and control measures for each permitted site; and stormwater monitoring and compliance plans.

Giant Gastric Ulcers: An Unusual Culprit, Aamer Abbass, Sameen Khalid, Vaishnavi Boppana, Joshua Hanson, Henry Lin, Denis Mccarthy

Pathology Research and Scholarship

Mycophenolate Mofetil (MMF) is routinely used immunosuppressant in solid organ transplantation is commonly associated with several gastrointestinal (GI) side effects. Here we present a case of giant gastric ulcer of 5 cm from MMF use post cardiac transplant. CASE DESCRIPTION: A 56-year-old male with history of severe ischemic cardiomyopathy post heart transplant was on immunosuppression with MMF, tacrolimus and prednisone for 5 months. He presented with severe epigastric pain and intermittent episodes of melena for 1 month. His pain radiated to back that is worsened with eating. Associated with loss of appetite, vomiting and 16-pound weight loss in 3 months. …

Climate Change Vulnerability Assessment Of Navajo Nation Water Resources In The San Juan River Basin, Nm: Utilizing Traditional Navajo Ecological Knowledge, Kirena Elana Yanibaa Tsosie

Water Resources Professional Project Reports

The Navajo Nation consists of 110 chapters, local government subdivisions, organized into five regional agencies. Over half of the Navajo Nation chapters have traditional names in the Navajo language that describe a local water source including springs, washes, rivers, ponds, and reservoirs. Therefore, traditional Navajo names consist of Traditional Navajo Ecological Knowledge (TNEK) and can assist in documenting water sources that can be further assessed for vulnerability and sensitivity to climate change. There are 52 Navajo Nation chapters located in the San Juan River Basin and 28 chapters have water related names. Water sources associated with place names will also …

Antibodies To Variable Domain 4 Linear Epitopes Of The Chlamydia Trachomatis Major Outer Membrane Protein Are Not Associated With Chlamydia Resolution Or Reinfection In Women, Amanda L. Collar, Alexandria C. Linville, Susan B. Core, Cosette M. Wheeler, William M. Geisler, David S. Peabody, Bryce Chackerian, Kathryn M. Frietze

Pathology Research and Scholarship

Chlamydia trachomatis is an obligate intracellular bacterium. C. trachomatis infection is the most prevalent bacterial sexually transmitted infection and can lead to pelvic inflammatory disease and infertility in women. There is no licensed vaccine for C. trachomatis prevention, in part due to gaps in our knowledge of C. trachomatis-specific immune responses elicited during human infections. Previous investigations of the antibody response to C. trachomatis have identified immunodominant antigens and antibodies that can neutralize infection in cell culture. However, epitope-specific responses to C. trachomatis are not well characterized, and the impact of these antibodies on infection outcome is unknown. We …

Faunal Remains From Archaeology Sites In Southwestern New Mexico, Karen Gust Schollmeyer, S. O. Macdonald

Occasional Papers

This study attempts to create a comprehensive catalog of all known records of faunal remains recovered from 105 archaeological sites located across southwestern New Mexico. These sites range in age from 2000BC to AD 1450. Approximately 250 taxa of mollusks, fishes, amphibians, reptiles, birds and mammals are represented in this compilation. Primary reference materials from published and unpublished sources are included, along with the repositories where relevant collections may be found for potential reexamination by researchers from a variety of fields of interest.

Comparison Of Virulence Gene Carriage In Staphylococcus Aureus Isolates Colonizing Human Skin And Those Associated With Soft Tissue Osteoarticular Infections, Kylie Disch, Jon Femling, Parisa Mortaji, Kurt Schwalm, Aimee Yousey, Rebekkah Varjabedian, Darrell Dinwiddie, Walter Dehority

2020 Pediatric Research Forum Session

Background:

Osteoarticular infections (OAI), most commonly caused by S. aureus, cause extreme morbidity in children and may result in permanent sequelae (e.g. limb-length discrepancies). However, S. aureus is also a common colonizing bacteria of skin and a cause of soft tissue abscesses. Virulence determinants for S. aureus are likely complex, and may include the genetic composition of the isolate, the host immune response and the transcriptomic profile of the organism. A necessary first-step in characterizing these virulence factors includes assessing virulence gene carriage between S. aureus isolates from children with OAIs and from less virulent isolates.

Methods:

S. aureus …

Prenatal Alcohol Exposure And Placental Insufficiency Results In Reduced Neuronal Complexity In The Rat Prefrontal Cortex, Nathaniel Pavlik, Jessie Newville, Clement P. Jose, Suzy Davies, Jennifer Wagner, Jonathan Brigman, Daniel Savage, Jessie R. Maxwell

2020 Pediatric Research Forum Session

Prenatal Alcohol Exposure (PAE) can produce long-term neurodevelopmental deficits and impaired executive function. Alcohol exposure during gestation is associated with impaired fetal development caused by placental insufficiency. The impact following PAE and placental insufficiency (PI) remains unknown. Utilizing a three-dimensional (3D) Sholl analysis, we hypothesized that PAE+PI will result in decreased neuronal complexity within the frontal cortex, a region critical to executive functioning.

Pregnant Long-Evans rats voluntarily drank 5% ethanol or saccharin water until embryonic day 18 (E18) to mimic moderate PAE. On E19, a laparotomy was performed to occlude the uterine artery for 60 minutes to induce PI. The …

Introducing The Self-Cleaning Filtration For Water Quality Sensors (Sc-Flawless) System, Aashish Sanjay Khandelwal

Civil Engineering ETDs

Sensor-based, semi-continuous observations of water quality parameters have become critical to understanding how changes in land use, management, and rainfall-runoff processes impact water quality at diurnal to multi-decadal scales. While some commercially available water quality sensors function adequately under a range of turbidity conditions, other instruments, including those used to measure nutrient concentrations, cease to function in high turbidity waters (> 100 NTU) commonly found in large rivers, arid-land rivers, and coastal areas. This is particularly true during storm events, when increases in turbidity are often concurrent with increases in nutrient transport. Here, we present the development and validation of …

Self-Regulation And Emotional Reactivity In Infants With Prenatal Exposure To Opioids And Alcohol, Kathryn G Beauchamp, Jean Lowe, Ronald M Schrader, Shikhar Shrestha, Crystal Aragón, Natalia Moss, Julia M Stephen, Ludmila N Bakhireva

Pediatrics Research and Scholarship

BACKGROUND: Infants with prenatal substance exposure are at increased risk for developmental problems, with self-regulatory challenges being some of the most pronounced. The current study aimed to investigate the extent to which prenatal substance exposure (alcohol, opioids) impacts infant self-regulation during a relational stressor and the association between self-regulation and infant affect.

METHODS: Participants were 100 mother-child dyads recruited prenatally (Mean = 23.8 gestational weeks) and completed the Still Face Paradigm (SFP) when infants were 5 to 8 months of age (Mean = 6.9 months) as part of an ENRICH prospective birth cohort study. Based on prospective repeated assessment of …

A Novel Flow Cytometric Assay To Identify Inhibitors Of Rbpj-Dna Interactions, Robert J. Lake, Mark K. Haynes, Kostiantyn Dreval, Rabeya Bilkis, Larry A. Sklar, Hua-Ying Fan

Pathology Research and Scholarship

Notch signaling is often involved in cancer cell initiation and proliferation. Aberrant Notch activation underlies more than 50% of T-cell acute lymphoblastic leukemia (T-ALL); accordingly, chemicals disrupting Notch signaling are of potential to treat Notch-dependent cancer. Here, we developed a flow cytometry-based high-throughput assay to identify compounds that disrupt the interactions of DNA and RBPJ, the major downstream effector of Notch signaling. From 1492 compounds, we identified 18 compounds that disrupt RBPJ-DNA interactions in a dose-dependent manner. Cell-based assays further revealed that auranofin downregulates Notch-dependent transcription and decreases RBPJ-chromatin interactions in cells. Most strikingly, T-ALL cells that depend on Notch …

Tcl1 Transgenic Mice As A Model For Cd49d-High Chronic Lymphocytic Leukemia, Eva Szenes, Andrea Härzschel, Sarah Decker, Erika Tissino, Justine Pischeli, Julia Christine Gutjahr, Sandra Kissel, Sandra Pennisi, Jan Philip Höpner, Alexander Egle, Nadja Zaborsky, Christine Dierks, Marie Follo, Alexandre Chigaev, Antonella Zucchetto, Richard Greil, Valter Gattei, Tanja Nicole Hartmann

Pathology Research and Scholarship

With the advent of small molecule inhibitors, sustained responses in chronic lymphocytic leukemia (CLL) patients have been achieved. Ibrutinib, an inhibitor of Bruton’s tyr- osine kinase (BTK), is a particularly potent treatment for CLL, with overall response rates of 82% in treatment-naive and 43% in relapsed-refractory patients [1]. These responses are accompanied by transient lymphocytosis in 50–70% of patients and a concomitant reduction of tumor burden in lymphoid organs [2]. We have recently demonstrated that the high-risk, CD49d-high CLL subgroup [3] displays reduced lymphocytosis and minor lymph node shrinkage upon ibru- tinib treatment [4]. CD49d is the alpha subunit of …

Cadmium Exposure Activates Akt/Erk Signaling And Pro-Inflammatory Cox-2 Expression In Human Gallbladder Epithelial Cells Via A Ros Dependent Mechanism, Priyanka Sharma, Trevar S. Caldwell, Megan N. Rivera, Rama R. Gullapalli

Pathology Research and Scholarship

Gallbladder cancer (GBC) is the commonest biliary tract cancer with an ill-defined etiology. We examined the role of Cd+2 exposures in a primary human gallbladder (GB) cell line model in this study. Cd+2 exposures induced decreased cell viability, reactive oxygen species (ROS) generation, altered Akt/ERK signaling pathway activation, PGE2 and COX-2 expression in a human primary gallbladder epithelial cell model. Pharmacological inhibitors were used to determine the key drivers of elevated COX-2 expression due to Cd+2 exposure. Our results show Cd+2 causes a dose- dependent reduction in GB cell viability (EC50 value – 18.6 μM). Dose-dependent activation of phospho-Akt and …

An Approach To Neutrosophic Dialogue And A Response To Wef's Great Reset: How Dialogue Is Required In Order To Preserve Social Justice With Anger Management, Victor Christianto, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

In recent debates, there are arguments on the role of anger in order to preserve social justice. For instance, in open democracy net, there is promoted phrase: "anger is the language of social justice." Others call for anger fueled with love (Sisonke Msimangs). Is that true? Is it achievable, the so-called "anger with love?"

Wagon Tracks Volume 34, Issue 4 (August 2020), Santa Fe Trail Association

Wagon Tracks

2 On the Cover: The Plainsman

4 Insights from your President

5 Joanne’s Jottings

Trail News

6-7 Rendezvous 2020, 2021 Symposium

8 Education, Jr. Wagon Master

9 In Memoriam: Ron Fox, Tony Juarez

10 Point of Rocks Closed to Public

11 SFTA/DAR Task Force Intro

12 New Mexico and the Cholera Epidemic of 1831-1833

14 Career and Legacy of Manuel Armijo

21 Speakers Bureau

22 Montgomery Bell: Businessman of NM

26 Hell on Wheels: Ellsworth, Kansas

29 Membership Form

29 Chapter Reports

32 Town of Westport

Privacy As A Civil Right, Alvaro M. Bedoya

New Mexico Law Review

As the first U.S.-born Hispanic senator, Senator Dennis Chávez of New Mexico left a rich legacy of advocacy for civil rights and civil liberties. In this lecture, the fourth U.S. Senator Dennis Chávez Endowed Lecture on Law and Civil Rights, I explore an idea at the intersection of those two bodies of law: the right to privacy. In 2020, the hallmark of surveillance is its ubiquity; “everyone is watched.” Unfortunately, this discourse erases the fact that, across American history, the burdens of government surveillance have fallen overwhelmingly on the shoulders of immigrants, heretics, people of color, the poor, and anyone …

The Investigation Of Surface Structures On Various Pathogens And Their Interactions With The Human Immune System, Carmen M. Villalobos

Biomedical Engineering ETDs

The cell surface is the first interface the host immune system encounters and

its investigation has led to a better understanding of cellular biology and types of

pathways that pathogens target in a host cell. The cell surface has evolved to include

many functions such as manipulation of the cytoskeleton, cell signaling, membrane

trafficking, adhesion, and integration into host tissue. The pathogens of interest are

the pathogenic fungus, Candida albicans, and the parasite, Giardia lamblia and we

investigate the consequences of drug treatments on the cell surface, leading to

promising new targets.

The Complicated History Of Environmental Racism, Victoria Peña-Parr

Black History at UNM

University of New Mexico Honors College Assistant Professor, Myrriah Gómez, defines and explores environmental racism, specifically its effects in New Mexico.

An Expanded Model Of Unmatter From Neutrosophic Logic Perspective: Towards Matter-Spirit Unity View, Florentin Smarandache, Victor Christianto, Robert Neil Boyd

Branch Mathematics and Statistics Faculty and Staff Publications

In Neutrosophic Logic, a basic assertion is that there are variations of about everything that we can measure; the variations surround three parameters called T, I, F (truth, indeterminacy, falsehood) which can take a range of values. A previous paper in IJNS, 2020 shortly reviews the links among aether and matter creation from the perspective of Neutrosophic Logic. In any case, matter creation process in nature stays a major puzzle for physicists, scientists and other science analysts. To this issue neutrosophic logic offers an answer: "unmatter." This paper examines an extended model of unmatter, to incorporate issue soul solidarity. So, …

A Rhetorical Analysis Through American Indian/Indigenous Tribal Leadership: The Rhetorics Of Four North American Tribal Leaders, Loyola Bird

English Language and Literature ETDs

I establish that there are American Indian rhetoric(s) still in place today, evidenced by the four tribal North American leaders that I interviewed. This dissertation project’s main focus was to examine their rhetorical practices and strategies, situated within tribally local, national and global political contexts. Tribal leaders are responsible for the management and leadership of American Indian/Indigenous nations throughout North America. Therefore, they must continue to create, utilize, and develop rhetorical strategies that enhance the art of persuasion for two different audiences (native and nonnative) for diverse reasons. The rhetorical settings may have changed slightly from when Sarah Winnemucca, Paiute, …

Imperial Myths, Abject Devotion: Mapping Affect In New Mexican Visual Culture And Discourse, N. C. Lira-Pérez

American Studies ETDs

New Mexican visual art and culture, as molded by state-sanctioned endeavors, is often casted in order to conceal the tension, conflict, and violence of settler colonialism and imperialism. Widely known myths of empire, such as the Tricultural myth, create a visualizing enterprise through which settler colonial logics transit and create political material reality. This thesis explores the following questions: How do New Mexican Hispanos and queer Chicanxs position themselves in relation to the logics of settler colonialism and empire? How are they positioned in relation to settler colonialism and empire? On the one hand, I argue that the state of …

Climate Change: Water Shortfalls In New Mexico, Eloise Alton Duncan

Climate Change and Public Health Preparedness

No abstract provided.

Climate Change And Community Health, Parasto Baghae Pour

Climate Change and Public Health Preparedness

No abstract provided.

Assessing The Environmental Impacts Of Urbanization In Siddharthanagar, Nepal, Bishal Raj Khanal

Economics ETDs

Rapid and haphazard infrastructural expansion often contributes to large negative externalities in cities. Environmental problems like air pollution and degradation of quality-of-life elements in an urban settlement are attributed to urban sprawl. Evidence based planning tools need to be developed which can help manage the rapid urbanization that is taking place in the developing world. In this context, we examine the relationship between health outcomes and the different spatial- temporal aspects of an urban-built environment in Siddharthanagar Metropolitan City which is a major settlement in southwestern Nepal. We attempt to identify the aspects of built environment which are closely associated …

The Origins And Development Of Textile Writing In Peru, William Mead Cheek

Art & Art History ETDs

Scholars once considered Inka khipus (14^th-16^th CE) to be a technological development unique to the Inka Empire. We now know that the earlier central Andean Wari (6^th-11^th CE) also made use of khipus, calling into question the Inka primacy of the technology. Understanding the origins and transformation of khipu notation in the Andes sheds light on the ways that information technologies figured into Andean state formation and administration, and impacts larger understandings of how tactile notational systems develop into writing and information storage. This study articulates how, just as the Inka inherited khipu technology …