Digital Commons Network^™

Sars-Cov-2 Reverse Genetics Reveals A Variable Infection Gradient In The Respiratory Tract, Yixuan J. Hou, Kenichi Okuda, Caitlin E. Edwards, David R. Martinez, Takanori Asakura, Kenneth H. Dinnon, Takafumi Kato, Rhianna E. Lee, Boyd L. Yount, Teresa M. Mascenik, Gang Chen, Kenneth N. Olivier, Andrew Ghio, Longping V. Tse, Sarah R. Leist, Lisa E. Gralinski, Alexandra Schäfer, Hong Dang, Rodney Gilmore, Satoko Nakano, Ling Sun, M Leslie Fulcher, Alessandra Livraghi-Butrico, Nathan I. Nicely, Mark Cameron, Cheryl Cameron, David J. Kelvin, Aravinda De Silva, David M. Margolis, Alena Markmann, Luther Bartelt, Ross Zumwalt, Fernando J. Martinez, Steven P. Salvatore, Alain Borczuk, Purushothama R. Tata, Vishwaraj Sontake, Adam Kimple, Ilona Jaspers, Wanda K. O'Neal, Scott H. Randell, Richard C. Boucher, Ralph S. Baric

Pathology Research and Scholarship

The mode of acquisition and causes for the variable clinical spectrum of coronavirus disease 2019 (COVID-19) remain unknown. We utilized a reverse genetics system to generate a GFP reporter virus to explore severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis and a luciferase reporter virus to demonstrate sera collected from SARS and COVID-19 patients exhibited limited cross-CoV neutralization. High-sensitivity RNA in situ mapping revealed the highest angiotensin-converting enzyme 2 (ACE2) expression in the nose with decreasing expression throughout the lower respiratory tract, paralleled by a striking gradient of SARS-CoV-2 infection in proximal (high) versus distal (low) pulmonary epithelial cultures. COVID-19 …

Danzantes Aztecas Y Promotoras Tradicionales: The Ritual Performances And Identity Politics Of A Mexican American Danzantes Aztecas Y Promotoras Tradicionales: The Ritual Performances And Identity Politics Of A Mexican American Ceremonial Community, Dina K. Barajas

American Studies ETDs

This dissertation is an ethnographic study which examined the ritual performances of an interconnected Mexican American and Mexican immigrant danza Azteca and curanderismo ceremonial community located in central and northern New Mexico, and central México. This project also explored if and how these rituals recognize the practitioners’ indigeneity. As a Mexican American and Native scholar and ceremonial participant of this community, I provided an “insider’s” understanding of the epistemologies and ontologies that inform these ceremonies. My positionality and methodology acted as a lens to critically examine danzantes’ and promotoras tradicionales’ claims of indigeneity. Importantly, this work provides a fluid conceptualization …

Wildfire Risks And Dangers, Brian Sanchez

Climate Change and Public Health Preparedness

No abstract provided.

Musical Wonder And Awe In Narnia: Comparing Two Related Emotions, Laura Steiner

Music ETDs

Wonder and awe are often considered to be synonyms. But though these emotions are similar, a more nuanced look at their musical representations reveals that they are not entirely the same. This thesis examines the difference between musical wonder and awe in music from The Lion, The Witch and the Wardrobe, a 2005 film about siblings who find a magical world in a wardrobe. After a review of the literature on musical wonder, the music from two scenes is analyzed. The wardrobe scene, in which the youngest child discovers the land of Narnia, depicts wonder visually. Certain musical characteristics, both …

Characterization Of The Overexpression Of The Native H+-Pumping Pyrophosphatase In The Microalga Picochlorum Soloecismus, Kimberly T. Wright

Biology ETDs

Microalgae are of interest for the creation of sustainable and cost competitive alternatives to petroleum-based fuels and chemicals. However, cultivation, extraction and processing of algal biomass requires improved yields to achieve economic feasibility. The advancement of microalgal biotechnology and various genetic engineering techniques allow the improvement of microalgae biomass for this purpose. Here, the characterization of the overexpression of the native vacuolar H+ pumping pyrophosphate (AVP1) in Picochlorum soloecismus was examined. AVP1 overexpression causes biomass increase in relevant plant crops. When overexpressed in this microalga it increases carbon storage in the form of starch in a closed laboratory photobioreactor. However, …

Sexual Dimorphism In Host Innate Response To Staphylococcus Aureus: Mechanisms Driving Sex Differences In Immune Cell Function And Host-Directed Interventions, Srijana Pokhrel

Biomedical Sciences ETDs

With the emerging antibiotic resistance, Staphylococcus aureus, primary causative agent of skin and soft tissue infections (SSTIs) as well as other life-threatening conditions has become a global health concern. While factors contributing to host defense against S. aureus SSTIs has been well studied, impact of sex as a variable has not been reported. In Chapter 2, we uncover the sex-specific differences in host response to S. aureus SSTIs and the contribution of female sex hormone, estrogen (E2) in providing protection in females. In Chapter 3, we identify mechanisms of innate differences in neutrophils bactericidal efficacy between sexes and in …

“Pre-Packaged Sovereignty”: The Fallacy Of Indian Self-Determination In The Bureau Of Indian Affairs (Bia) Tribal Social Services Programs, April Kateri Chavez

American Studies ETDs

This thesis examines the Bureau of Indian Affairs (BIA) tribal social services programs in New Mexico Native reservation communities. I rely on interviews with current/former BIA social workers and administrators to contextualize my analysis, while revealing the limits of existing social work scholarship and offering recommendations for future scholarship and community work. Using critical Indigenous studies and feminisms along with critical social work, I advance two primary arguments. The first is, despite the so-called self-determination era, the Bureau of Indian Affairs (BIA) functions as a settler colonial administration that diminishes tribal sovereignty and perpetuates racist and gendered violence. The capacity …

Virus-Like Particle-Based Vaccines Induce Antibody-Mediated Neutralization Of Staphylococcus Aureus Virulence, Jason Alexander Joyner

Biomedical Sciences ETDs

Staphylococcus aureus is a pathogenic bacterium that inflicts a large amount of human suffering using an arsenal of virulence factors to cause minor to life-threatening infections. Both the accessory gene regulator (agr) operon, a virulence regulatory pathway that controls expression of over 200 virulence factors, and alpha-hemolysin (Hla), a key pore-forming toxin, play a significant role in infection severity. Given the clinical trial failures of S. aureus vaccine candidates and the prevalence of antibiotic-resistant strains, novel and effective treatment options are urgently needed. Chapter 2 describes a novel virus-like particle (VLP) -based vaccine inducing agr-I-inhibiting antibodies …

Spatial Analysis Of Bias Corrected Rainfall Data Sets Within Albuquerque, New Mexico Metropolitan Area, Cassy Scarlott- Mcclintock

Civil Engineering ETDs

The Next Generation Radar (NEXRAD) was implemented as one of the first network-wide operational radar- estimated precipitation products in the United States in 1988. The algorithms within this system bring drastic advancements to operational flood forecasting when compared to prior radars and even rain gage systems. The objectives were; (1) to determine how radar plays a role in estimating precipitation by comparing rainfall accuracy to other sources such as calibrated radar data and gage data within Albuquerque, New Mexico and (2) to determine if distance from the radar affects estimation of rainfall. The sets of data compared were from: (1) …

Nubians Of Plutonia: Black Women In Modern Post-Apocalyptic And Dystopian Graphic Literature, Marthia D. Fuller

American Studies ETDs

This dissertation explores the deployment of race and gender in comic books and graphic novels, paying close attention to how Black womanhood and girlhood operates in the speculative future. This project suggests that the framing of black womanhood and girlhood in post-apocalyptic/dystopian spaces provide a counter to the normative notions of both while simultaneously using normative tropes of Black womanhood and girlhood to produce new ways of understanding Black femininity in the future. Nubians of Plutonia use Black feminist cultural criticisms, Black popular culture, and visual culture to ask: does graphic literature present new, more dynamic understandings of race and …

Bodies In Shame: Writing Trauma And Affective Unsettlement In Post-Genocide Rwanda Fiction, Cole A. Carvour

Foreign Languages & Literatures ETDs

This thesis analyzes Boubacar Boris Diop’s Murambi, le livre des ossements and Véronique Tadjo’s L’Ombre d’Imana: voyages jusqu’au bout du Rwanda. I argue that both authors write trauma by employing both a dominant realist style and the trauma aesthetic with attention to the embodied experiences of genocide victims and survivors in both styles. In doing so, each author contributes to impeding indifference surrounding the 1994 Rwandan genocide. Furthermore, I assert that one effect of writing trauma is that of affective unsettlement or affective travel, or the registering of psychic and physical shame and other related affective responses in the …

Relationship Between Orthostatic Stress Response And Acute Mountain Sickness Susceptibility At High Altitude: A Pilot Study, Bryanne Bellovary, Jack Loeppky, Andrew Wells, Zac Fennel, Jeremy Ducharme, Jonathan Houck, Trevor Mayschak, Kelsey Bourbeau, Ann Gibson, Scott Drum, Christine Mermier

Health, Exercise, and Sports Sciences ETDs

The purpose of this study was to determine whether there is a difference in hemodynamic responses to head-up tilt (HUT) in subjects who do, and do not, experience acute mountain sickness (AMS) during exposure to hypobaric hypoxia. Secondarily, we aimed to determine if those hemodynamic variables altered during HUT correlated with AMS severity. Fifteen participants completed three testing sessions: 1) VO₂max test to determine workload at 50% VO₂max for hypoxia exposure; 2) HUT test consisting of supine rest for 20 min followed by 70° upright tilting for ≤ 40 min; and 3) six hours of hypobaric …

The Effect Of Semantic Neighborhood Density On Vocabulary Learning In Spanish As A Second Language And Spanish As A Heritage Language, Marián Giráldez Elizo

Language, Literacy, and Sociocultural Studies ETDs

This dissertation reviews the results from an online survey created to identify and compare how second language (L2) learners and heritage language (HL) learners of Spanish, enrolled in beginning-level coursework at the college level, acquired and built vocabulary. A total of 451 participants completed the survey. The purpose of the online survey was to serve as a baseline for pedagogical purposes, since it provided information about participants’ language profiles and the way they build vocabulary based on sematic relatedness. Overall, the findings from the survey showed that HL and L2 learners differ in the way they build semantic neighborhoods and, …

The Magic Of Love: Love Magic In Medieval Romance, Dalicia Raymond

English Language and Literature ETDs

This project examines authorial representations of the morality of three functions of love magic: to induce, to disrupt, and to facilitate love in twelfth- through fifteenth-century Middle High German, Old French, and Middle English romances. Using a cultural studies approach with close textual analysis and informed by gender studies, it investigates medieval romance authors’ discomfort with love inducing magic and asserts that this discomfort is a response to the magic’s violation of free will, a central tenet of medieval theology. I find that authors condemn love inducing magic but mark specific instances acceptable through explicit clarification of divine approval. Love …

A Generalized Neutrosophic Solid Transportation Model With Insufficient Supply, Nilabhra Paul, Deepshikha Sarma, Akash Singh, Uttam Kumar Bera

Neutrosophic Sets and Systems

No abstract provided.

Assessment Of Mcdm Problems By Todim Using Aggregated Weights, A. Sahaya Sudha, Luiz Flavio Autran Monteiro Gomes, K. R. Vijayalakshmi

Neutrosophic Sets and Systems

No abstract provided.

Unm Pathology Pathfinder Summer 2020, Unm Department Of Pathology

Newsletters

No abstract provided.

Intersectionality Between Sex/Gender And Race/Ethnicity On Cognitive Trajectories And Development Of Alzheimer’S Disease, Justina Frances Avila-Rieger

Psychology ETDs

The current study examined the interactive effects of race/ethnicity and sex/gender on cognitive trajectories of older adults. Participants were a total of 5258 non-Hispanic White (NHW), Black, and Hispanic men and women in the Washington/Hamilton Heights/Inwood Columbia Aging Project. Multiple-group latent growth curve modeling was used to examine trajectories across sex/gender by racial/ethnic groups and to determine the relationship between specific socio-cultural/health indicators and cognitive decline, including childhood socioeconomic position, years of education, adult income and occupation, cardiovascular risk factors, and marital status. Sex/gender differences in baseline cognitive test performance varied as a function of race/ethnicity and racial/ethnic differences in …

Current Advances In Transfusion Medicine: A 2019 Review Of Selected Topics From The Aabb Clinical Transfusion Medicine Committee, Monica B. Pagano, Elizabeth S. Allen, Stella T. Chou, Nancy M. Dunbar, Thomas Gniadek, Ruchika Goel, Sarah K. Harm, Courtney K. Hopkins, Jessica Jacobson, Parvez M. Lokhandwala, Ryan A. Metcalf, Jay S. Raval, Joseph Schwartz, Hua Shan, Philip C. Spinella, Emily Storch, Claudia S. Cohn

Pathology Research and Scholarship

BACKGROUND: The AABB Clinical Transfusion Medicine Committee (CTMC) compiles an annual synopsis of the published literature covering important developments in the field of transfusion medicine (TM) for the board of director's review. This synopsis is now made available as a manuscript published in TRANSFUSION.

STUDY DESIGN AND METHODS: CTMC committee members review original manuscripts including TM-related topics published in different journals between late 2018 and 2019. The selection of topics and manuscripts are discussed at committee meetings and are chosen based on relevance and originality. After the topics and manuscripts are selected, committee members work in pairs to create a …

New Mexico Children's Alliance Children's Advocacy Centers Needs Assessment, Theresa H. Cruz, Leona Woelk, Ivy Vitanzos Cervantes, Emily Guerra

Reports & Documents

No abstract provided.

Consumption Of Traditional Alaska Native Foods As It Relates To Health, Hunter Marshall

Theoretical Foundation in Advanced Practice Nursing

No abstract provided.

Unm Global Health Covid-19 Therapeutic Evidence, Unm Global Health Covid-19 Briefing Team

HSC Covid 19 Briefings

No abstract provided.

2020-06-19/20/21 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Ingrid Hendrix, Lori D. Sloane, Mari Anixter, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Morgan Edwards-Fligner, Melissa Cossé, Cristian Bologa, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

NM Highlights: Dr. Scrase on-line briefing. NM cases. Campgrounds closed through July 4th. Otero prison reports. Navajo nation’s first police dies. Santa Fe cancels 4th July fireworks. Face coverings donated. NM infection rate drops. US Highlights: AZ Governor issues Exec Order. Economics, Workforce, Supply Chain, PPE: Epidemiology Highlights: Reopening hospitals metric. Comparison of mask effectiveness. Private practices suffer. Healthcare Policy Recommendations: Maternal mortality. Practice Guidelines: Recommendations on hepatobiliary surgery and neonate management. Drugs, Vaccines, Therapies, Clinical Trials: Animal studies generate new vaccine candidates and vaccine platform. 16 new clinical trials registered. Other Science: Respiratory secretions detected by trained …

Molecular Interplay Between Dormant Bone Marrow-Resident Cells (Bmrcs) And Ctcs In Breast Cancer., Debasish Boral, S Ray Kenney, Dario Marchetti, Haowen N. Liu

Pathology Research and Scholarship

Despite widespread knowledge that bone marrow-resident breast cancer cells (BMRCs) affect tumor progression, signaling mechanisms of BMRCs implicated in maintaining long-term dormancy have not been characterized. To overcome these hurdles, we developed a new experimental model of clinical dormancy employing patient-isolated Circulating Tumor Cells (de novo CTCs) and their injection in xenografts with subsequent tumor monitoring and CTC characterization (ex vivo CTCs). We hypothesized that significant distinctions exist between signaling pathways of bone marrow-homing vs metastasis-competent CTCs upon transplantation in xenografts. Comparative transcriptomic analyses of ex vivo vs de novo CTCs identified increased mTOR signaling-a critical pathway frequently dysregulated in …

2020-06-15/16 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Lori D. Sloane, Mari Anixter, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Morgan Edwards=Fligner, Clinton Onyango, Cristian Bologa, Kristine Tollestrup, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

NM Highlights: NM case updates. Tribal outreach campaign. Santa Fe firefighters support first responders. US Highlights: COVID-19 hospitalizations rise in Texas. US retail sales up in May. Projected COVID-19 deaths in US. International Highlights: COVID-19 prevention and control in Africa. COVID-19 response and challenge in Africa. Epidemiology Highlights: Herd immunity in Europe. Social distance measures effects. Modeling infections in India. Fecal analysis. Wastewater-based Epidemiology Consortium. Healthcare Policy Recommendations: Public health approach to lockdown debate. All of Us Program adds new COVID-19 initiatives. Practice Guidelines: Guidelines are reviewed on urology care. IBD endoscopy. Convalescent plasma use. Testing: Patient predictors …

2020-06-10/11 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Lori D. Sloane, Mari Anixter, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Natalie Adolphi, Morgan Edwards-Fligner, Melissa Cossé, Alexandra Yingling, Perez Olewe, Cristian Bologa, Kristine Tollestrup, Orrin Myers, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

NM Highlights: Governer’s update on COVID-19 efforts. NM case count. Testing for food industry workers. Testing for lawmakers and staffers. Face coverings mandatory in Santa Fe. Lawmakers prepare to $2.4B budget hole. Learning loss due to lockdown. US Highlights: EPA orders unsafe products removed. Cases on the rise after roll back. Economics, Workforce, Supply Chain, PPE: Governments need more money. Study on masks. Hearing impaired masks. Fast spread in Africa. Kenya’s economic slowdown. Epidemiology Highlights: White House Task Force warns of spikes. Mortality risk factors. Higher mortality in cancer patients. UV-C disinfection of mobile phones. Practice Guidelines: Benefits …

Wagon Tracks Volume 34, Issue 3 (May 2020)

Wagon Tracks

2 On the Cover: All Trails Lead to Santa Fe by Ron Kil, Larry Short

4 Insights from your President

5 Joanne’s Jottings

6 Rendezvous 2020 and 2021 Symposium

7 Trail News

8 In Memoriam: Mary Jean Straw Cook, Willard "Dub" Couch, Louann Jordan, Alma Gregory

10 Nestor Armijo: The Capitalist from Las Cruces

17 Lee Kroh Leaves Legacy: USGS Quad Maps

18 Voices from a Disease Frontier: Kansans and Cholera 1867

28 Hell on Wheels: Railhead Towns on the Santa Fe Trail

33 Membership Form

33 Chapter Reports

36 Recipes from the Trail

2020-06-8/9 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Ingrid Hendrix, Lori D. Sloane, Mari Anixter, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Karen Armitage, Jenny Situ, Morgan Edwards-Fligner, Clinton Onyango, Perez Olewe, Cristian Bologa, Kristine Tollestrup, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

NM Highlights: Governor’s interview. NM case count. Longer furlough for Santa Fe city employees. ABQ playgrounds reopening. Mask madness tournament. COVID-19 spending receipts. Zagster closes operations in ABQ. US Highlights: Shutdowns prevented deaths. Foster care delays. International Highlights: Scientist strike for anti-racism. New Zealand lifts lockdowns. Economics, Workforce, Supply Chain, PPE: WHO updates mask guidance. Software to manage PPE distribution. Centrifugation testing of masks. Sustain and preserve early career investigators. Epidemiology Highlights: WHO walks back statement on asymptomatic spread. Non-pharmaceutical interventions successful. Increased risk to intellectually and developmentally disabled. Epidemiologist risk tolerance surveyed. Healthcare Policy Recommendations: Public health …

Job Loss, Gabriella Herrera

Climate Change and Public Health Preparedness

No abstract provided.

Early Isotopic Evidence For Maize As A Staple Grain In The Americas, Douglas J. Kennett, Keith M. Prufer, Brendan J. Culleton, Richard J. George, Mark Robinson, Willa R. Trask, Gina M. Buckley, Emily Moes, Emily J. Kate, Thomas K. Harper, Lexi O'Donnell, Erin E. Ray, Ethan C. Hill, Asia Alsgaard, Christopher Merriman, Clayton Meredith, Heather J H Edgar, Jaime J. Awe, Said M. Gutierrez

Pathology Research and Scholarship

Maize is a cultigen of global economic importance, but when it first became a staple grain in the Americas, was unknown and contested. Here, we report direct isotopic dietary evidence from 52 radiocarbon-dated human skeletons from two remarkably well-preserved rock-shelter contexts in the Maya Mountains of Belize spanning the past 10,000 years. Individuals dating before ~4700 calendar years before present (cal B.P.) show no clear evidence for the consumption of maize. Evidence for substantial maize consumption (~30% of total diet) appears in some individuals between 4700 and 4000 cal B.P. Isotopic evidence after 4000 cal B.P. indicates that maize became …