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Poster 14, Nelson Espinosa Jul 2021

Poster 14, Nelson Espinosa

Drug Discovery and Development Colloquium

No abstract provided.

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Identification Of Human Kinin-Forming Enzyme Inhibitors From Medicinal Herbs, Hassan Madkhali, Amer Tarawneh, Zulfiqar Ali, Hoang V. Le Jul 2021

Identification Of Human Kinin-Forming Enzyme Inhibitors From Medicinal Herbs, Hassan Madkhali, Amer Tarawneh, Zulfiqar Ali, Hoang V. Le

Faculty and Student Publications

The goal of this study was to assess the pharmacological effects of black tea (Camellia sinensis var. assamica) water extract on human kinin-forming enzymes in vitro. Tea is a highly consumed beverage in the world. Factor XII (FXII, Hageman factor)-independent-and-dependent activation of prekallikrein to kallikrein leads to the liberation of bradykinin (BK) from high-molecular-weight kininogen (HK). The excessive BK production causes vascular endothelial and nonvascular smooth muscle cell permeability, leading to angioedema. The prevalence of angiotensin-converting enzyme inhibitor (ACEI)-induced angioedema appears to be through BK. Both histamine and BK are potent inflammatory mediators. However, the treatments for histamine-mediated angioedema are …

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Structure–Activity Relationships Of The Antimalarial Agent Artemisinin 10. Synthesis And Antimalarial Activity Of Enantiomers Of Rac-5Β-Hydroxy-D-Secoartemisinin And Analogs: Implications Regarding The Mechanism Of Action, Mohamed Jahan, Francisco Leon, Frank R. Fronczek, Khaled M. Elokely Jul 2021

Structure–Activity Relationships Of The Antimalarial Agent Artemisinin 10. Synthesis And Antimalarial Activity Of Enantiomers Of Rac-5Β-Hydroxy-D-Secoartemisinin And Analogs: Implications Regarding The Mechanism Of Action, Mohamed Jahan, Francisco Leon, Frank R. Fronczek, Khaled M. Elokely

Faculty and Student Publications

An efficient synthesis of rac-6-desmethyl-5β–hydroxy-D-secoartemisinin 2, a tricyclic analog of R-(+)-artemisinin 1, was accomplished and the racemate was resolved into the (+)-2b and (−)-2a enantiomers via their Mosher Ester diastereomers. Antimalarial activity resided with only the artemisinin-like enantiomer R-(−)-2a. Several new compounds 9–16, 19a, 19b, 22 and 29 were synthesized from rac-2 but the C-5 secondary hydroxyl group was surprisingly unreactive. For example, the formation of carbamates and Mitsunobu reactions were unsuccessful. In order to assess the unusual reactivity of 2, a single crystal X-ray crystallographic analysis revealed a close intramolecular hydrogen bond from the C-5 alcohol to the oxepane …

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Graduate Student Council Research Grants Further Range Of Research, Shea Stewart Jul 2021

Graduate Student Council Research Grants Further Range Of Research, Shea Stewart

University of Mississippi News

Twenty students awarded grants for research, creative scholarship pursuits

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Assessment Of Evolutionary Relationships For Prioritization Of Myxobacteria For Natural Product Discovery, Andrew Ahearne, Hanan Albataineh, Scot E. Dowd, D. Cole Stevens Jul 2021

Assessment Of Evolutionary Relationships For Prioritization Of Myxobacteria For Natural Product Discovery, Andrew Ahearne, Hanan Albataineh, Scot E. Dowd, D. Cole Stevens

Faculty and Student Publications

Discoveries of novel myxobacteria have started to unveil the potentially vast phylogenetic diversity within the family Myxococcaceae and have brought about an updated approach to myxobacterial classification. While traditional approaches focused on morphology, 16S gene sequences, and biochemistry, modern methods including comparative genomics have provided a more thorough assessment of myxobacterial taxonomy. Herein, we utilize long-read genome sequencing for two myxobacteria previously classified as Archangium primigenium and Chondrococcus macrosporus, as well as four environmental myxobacteria newly isolated for this study. Average nucleotide identity and digital DNA–DNA hybridization scores from comparative genomics suggest previously classified as A. primigenium to instead be …

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Transcriptomic Changes And The Roles Of Cannabinoid Receptors And Pparγin Developmental Toxicities Following Exposure To Δ9-Tetrahydrocannabinol And Cannabidiol, Zacharias Pandelides, Neelakanteswar Aluru, Cammi Thornton, Haley E. Watts Jul 2021

Transcriptomic Changes And The Roles Of Cannabinoid Receptors And Pparγin Developmental Toxicities Following Exposure To Δ9-Tetrahydrocannabinol And Cannabidiol, Zacharias Pandelides, Neelakanteswar Aluru, Cammi Thornton, Haley E. Watts

Faculty and Student Publications

Human consumption of cannabinoid-containing products during early life or pregnancy is rising. However, information about the molecular mechanisms involved in early life stage Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) toxicities is critically lacking. Here, larval zebrafish (Danio rerio) were used to measure THC- and CBD-mediated changes on transcriptome and the roles of cannabinoid receptors (Cnr) 1 and 2 and peroxisome proliferator activator receptor γ(PPARγ) in developmental toxicities. Transcriptomic profiling of 96-h postfertilization (hpf) cnr+/+ embryos exposed (6 - 96 hpf) to 4 μM THC or 0.5 μM CBD showed differential expression of 904 and 1095 genes for THC and CBD, respectively, …

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The Remains Of The Fray: Nascent Colonialism And Heterogeneous Hybridity, Charles R. Cobb, James B. Legg, Steven D. Smith, Chester B. Depratter, Brad R. Lieb, Edmond A. Boudreaux Jul 2021

The Remains Of The Fray: Nascent Colonialism And Heterogeneous Hybridity, Charles R. Cobb, James B. Legg, Steven D. Smith, Chester B. Depratter, Brad R. Lieb, Edmond A. Boudreaux

Faculty and Student Publications

Investigations at the Native American site complex of Stark Farms in Mississippi, USA, have yielded numerous examples of metal artifacts of European origin. Our study suggests that they derive from contact between the AD 1540-1541 winter encampment of the Spanish Hernando de Soto expedition and the local Indigenous polity. The artifacts display a wide range of modifications, uses, and depositional contexts congruent with hybrid practices. We argue that the early colonial setting of Stark Farms requires a different perspective on cultural mixing than is often applied in studies of European colonialism. This is highlighted by the strongly improvisational nature of …

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Tenure And Promotion Announcement, 2021, University Of Mississippi. Provost Jul 2021

Tenure And Promotion Announcement, 2021, University Of Mississippi. Provost

Tenure and Promotion Announcements

No abstract provided.

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Physics Professor Lands Top Acoustical Society Of America Award, Shea Stewart Jun 2021

Physics Professor Lands Top Acoustical Society Of America Award, Shea Stewart

University of Mississippi News

Likun Zhang awarded R. Bruce Lindsay Award for early-career acoustics work

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On The Move: Sloths And Their Epibionts As Model Mobile Ecosystems, Maya Kaup, Sam Trull, Erik F. Y. Hom Jun 2021

On The Move: Sloths And Their Epibionts As Model Mobile Ecosystems, Maya Kaup, Sam Trull, Erik F. Y. Hom

Faculty and Student Publications

Sloths are unusual mobile ecosystems, containing a high diversity of epibionts living and growing in their fur as they climb slowly through the canopies of tropical forests. These epibionts include poorly studied algae, arthropods, fungi, and bacteria, making sloths likely reservoirs of unexplored biodiversity. This review aims to identify gaps and eliminate misconceptions in our knowledge of sloths and their epibionts, and to identify key questions to stimulate future research into the functions and roles of sloths within a broader ecological and evolutionary context. This review also seeks to position the sloth fur ecosystem as a model for addressing fundamental …

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Pharmacy School Dean Receives Distinguished Service Award, Whitney Tarpy Jun 2021

Pharmacy School Dean Receives Distinguished Service Award, Whitney Tarpy

University of Mississippi News

David D. Allen recognized for contributions to the biological sciences

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Ethiopian Medicinal Plants Traditionally Used For The Treatment Of Cancer; Part 3: Selective Cytotoxic Activity Of 22 Plants Against Human Cancer Cell Lines, Solomon Tesfaye, Hannah Braun, Kaleab Asres, Ephrem Engidawork Jun 2021

Ethiopian Medicinal Plants Traditionally Used For The Treatment Of Cancer; Part 3: Selective Cytotoxic Activity Of 22 Plants Against Human Cancer Cell Lines, Solomon Tesfaye, Hannah Braun, Kaleab Asres, Ephrem Engidawork

Faculty and Student Publications

Medicinal plants have been traditionally used to treat cancer in Ethiopia. However, very few studies have reported the in vitro anticancer activities of medicinal plants that are collected from different agro‐ecological zones of Ethiopia. Hence, the main aim of this study was to screen the cytotoxic activities of 80% methanol extracts of 22 plants against human peripheral blood mononuclear cells (PBMCs), as well as human breast (MCF‐7), lung (A427), bladder (RT‐4), and cervical (SiSo) cancer cell lines. Active extracts were further screened against human large cell lung carcinoma (LCLC‐103H), pancreatic cancer (DAN‐G), ovarian cancer (A2780), and squamous cell carcinoma of …

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Agricultural Conservation Practices And Aquatic Ecological Responses, Richard E. Lizotte, Peter C. Smiley, Robert B. Gillespie, Scott S. Knight Jun 2021

Agricultural Conservation Practices And Aquatic Ecological Responses, Richard E. Lizotte, Peter C. Smiley, Robert B. Gillespie, Scott S. Knight

Faculty and Student Publications

Conservation agriculture practices (CAs) have been internationally promoted and used for decades to enhance soil health and mitigate soil loss. An additional benefit of CAs has been mitigation of agricultural runoff impacts on aquatic ecosystems. Countries across the globe have agricultural agencies that provide programs for farmers to implement a variety of CAs. Increasingly there is a need to demonstrate that CAs can provide ecological improvements in aquatic ecosystems. Growing global concerns of lost habitat, biodiversity, and ecosystem services, increased eutrophication and associated harmful algal blooms are expected to intensify with increasing global populations and changing climate. We conducted a …

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Evidence That Maackia Amurensis Seed Lectin (Masl) Exerts Pleiotropic Actions On Oral Squamous Cells With Potential To Inhibit Sars-Cov-2 Infection And Covid-19 Disease Progression, Stephanie A. Sheehan, Kelly L. Hamilton, Edward P. Retzbach, Premalatha Balachandran Jun 2021

Evidence That Maackia Amurensis Seed Lectin (Masl) Exerts Pleiotropic Actions On Oral Squamous Cells With Potential To Inhibit Sars-Cov-2 Infection And Covid-19 Disease Progression, Stephanie A. Sheehan, Kelly L. Hamilton, Edward P. Retzbach, Premalatha Balachandran

Faculty and Student Publications

COVID-19 was declared an international public health emergency in January, and a pandemic in March of 2020. There are over 125 million confirmed COVID-19 cases that have caused over 27 million deaths worldwide as of March 2021. COVID-19 is caused by the SARS-CoV-2 virus. SARS-CoV-2 presents a surface “spike” protein that binds to the ACE2 receptor to infect host cells. In addition to the respiratory tract, SARS-Cov-2 can also infect cells of the oral mucosa, which also express the ACE2 receptor. The spike and ACE2 proteins are highly glycosylated with sialic acid modifications that direct viral-host interactions and infection. Maackia …

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Linear Discriminant Analysis Based On Gas Chromatographic Measurements For Geographical Prediction Of Usa Medical Domestic Cannabis, Ramia Z. Al Bakain, Yahya S. Al-Degs, James V. Cizdziel, Mahmoud A. Elsohly Jun 2021

Linear Discriminant Analysis Based On Gas Chromatographic Measurements For Geographical Prediction Of Usa Medical Domestic Cannabis, Ramia Z. Al Bakain, Yahya S. Al-Degs, James V. Cizdziel, Mahmoud A. Elsohly

Faculty and Student Publications

Fifty four domestically produced cannabis samples obtained from different USA states were quantitatively assayed by GC-FID to detect 22 active components: 15 terpenoids and 7 cannabinoids. The profiles of the selected compounds were used as inputs for samples grouping to their geographical origins and for building a geographical prediction model using Linear Discriminant Analysis. The proposed sample extraction and chromatographic separation was satisfactory to select 22 active ingredients with a wide analytical range between 5.0 and 1,000 μg/mL. Analysis of GC-profiles by Principle Component Analysis retained three significant variables for grouping job (Δ9-THC, CBN, and CBC) and the modest discrimination …

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Latewood Ring Width Reveals Ce 1734 Felling Dates For Walker House Timbers In Tupelo, Mississippi, Usa, Thomas W. Patterson, Grant L. Harley, David H. Holt, Raymond T. Doherty, Daniel J. King, Karen J. Heeter, Ashley L. Chasez, Alyssa C. Crowell, Ian M. Stewart Jun 2021

Latewood Ring Width Reveals Ce 1734 Felling Dates For Walker House Timbers In Tupelo, Mississippi, Usa, Thomas W. Patterson, Grant L. Harley, David H. Holt, Raymond T. Doherty, Daniel J. King, Karen J. Heeter, Ashley L. Chasez, Alyssa C. Crowell, Ian M. Stewart

Faculty and Student Publications

Dendroarchaeology is under-represented in the Gulf Coastal Plain region of the United States (US), and at present, only three published studies have precision dated a collection of 18th–19th-century structures. In this study, we examined the tree-ring data from pine, poplar, and oak timbers used in the Walker House in Tupelo, Mississippi. The Walker House was constructed ca. the mid-1800s with timbers that appeared to be recycled from previous structures. In total, we examined 30 samples (16 pines, 8 oaks, and 6 poplars) from the attic and crawlspace. We cross-dated latewood ring growth from the attic pine samples to the period …

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Pharmacy Matters - June 2021, University Of Mississippi. School Of Pharmacy Jun 2021

Pharmacy Matters - June 2021, University Of Mississippi. School Of Pharmacy

Pharmacy Matters Newsletters

Featured stories: "GlyCORE to Host Inaugural Mid-South Glycoscience Meeting," "Learning from Each Other," "Helping His State Through Pharmacy," "Starting a New Tradition"

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The Effect Of Sampling Density And Study Area Size On Landscape Genetics Inferences For The Mississippi Slimy Salamander (Plethodon Mississippi), Stephanie M. Burgess, Ryan C. Garrick Jun 2021

The Effect Of Sampling Density And Study Area Size On Landscape Genetics Inferences For The Mississippi Slimy Salamander (Plethodon Mississippi), Stephanie M. Burgess, Ryan C. Garrick

Faculty and Student Publications

In landscape genetics, it is largely unknown how choices regarding sampling density and study area size impact inferences upon which habitat features impede vs. facilitate gene flow. While it is recommended that sampling locations be spaced no further apart than the average individual's dispersal distance, for low-mobility species, this could lead to a challenging number of sampling locations, or an unrepresentative study area. We assessed the effects of sampling density and study area size on landscape genetic inferences for a dispersal-limited amphibian, Plethodon mississippi, via analysis of nested datasets. Microsatellite-based genetic distances among individuals were divided into three datasets representing …

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Downhill Running Impairs Peripheral But Not Central Neuromuscular Indices In Elbow Flexor Muscles, Xin Ye, Robert J. Benton, William M. Miller, Sunggun Jeon, Jun Seob Song Jun 2021

Downhill Running Impairs Peripheral But Not Central Neuromuscular Indices In Elbow Flexor Muscles, Xin Ye, Robert J. Benton, William M. Miller, Sunggun Jeon, Jun Seob Song

Faculty and Student Publications

The purpose of this study was to examine the effects of a 1-h downhill running exercise on the elbow flexor muscles’ neuromuscular functions. Seventeen adults (Control [CON]: n = 9; Experimental [EXP]: n = 8) completed this study. The CON rested for 30 min while the EXP performed the downhill running. Before, 10 min, 24 h, and 48 h after the interventions, dependent variables (knee extensor muscle soreness, elbow flexion and knee extension isometric strength, elbow flexion resting twitch and voluntary activation [VA], and the biceps surface electromyography [EMG] amplitude) were measured. Knee extensor muscle soreness was significantly greater in …

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A Theoretical Study Of Synchronous Proton Transfer In (Hf)N, (H2O) N, And (Hcl) N Where N = 3, 4, 5, Johnny Yang May 2021

A Theoretical Study Of Synchronous Proton Transfer In (Hf)N, (H2O) N, And (Hcl) N Where N = 3, 4, 5, Johnny Yang

Honors Theses

For (HF)n, (H2O)n, and (HCl)n (n = 3 − 5), we have rigorously characterized the structures for the minima and transition states for synchronous proton transfer (SPT) with the CCSD(T) method and aug-cc-pVTZ basis set. The electronic barrier heights (∆E†) associated with these transition states have also been computed with the explicitly correlated CCSD(T)-F12 method and the aug-cc-pVQZ-F12 basis set (abbreviated aQZ-F12). (HCl)n (n = 3 − 5) SPT transition states have not been previously identified to the best of our knowledge, and they have been found …

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Resilient Nursing - Journey To Commencement, Annie Oeth May 2021

Resilient Nursing - Journey To Commencement, Annie Oeth

Journey to Commencement

Critical care at heart for School of Nursing graduate Makenzie Byrd

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Research Trends In Amish Population Health, A Growing Literature About A Growing Rural Population, Cory Anderson, Lindsey Potts May 2021

Research Trends In Amish Population Health, A Growing Literature About A Growing Rural Population, Cory Anderson, Lindsey Potts

Journal of Rural Social Sciences

The Amish are an endogamous rural population experiencing rapid growth; consequently, they have attracted the attention of population health researchers and service providers. With approximately one quarter of all Amish studies publications now devoted to population health (n=246), the time is ripe to review research trends. Using bibliometric measures, we map the genealogy, influence, and configuration of Amish health publications. Amish population health research has (1) a health culture-focused core with clusters representing social science and health practice, (2) peripheral clusters addressing health conditions–mental, physical, and injury/safety–and (3) several clusters straddling both. We identify fruitful interdisciplinary studies and recommend researchers …

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(Sympathy For) The Devil You Know: Openness, Psychological Entropy, And The Case Of The Incumbency Advantage, Adam J. Ramey, Jonathan D. Klingler, Gary E. Hollibaugh May 2021

(Sympathy For) The Devil You Know: Openness, Psychological Entropy, And The Case Of The Incumbency Advantage, Adam J. Ramey, Jonathan D. Klingler, Gary E. Hollibaugh

Faculty and Student Publications

Why do some individuals prefer lesser-known, riskier experiences over more well-known options in life? In this paper, we focus on the case of the electoral advantage to incumbency, and the role that psychological entropy reduction can play in undermining that advantage among individuals who lack simplifying heuristics, such as party brand loyalty. We build on recent work in political psychology, applying a more general political psychology framework linking the Big Five personality trait of Openness to a compulsion to gather and process information. Using data from the 2014 and 2016 Cooperative Congressional Election Studies, we find more Open respondents are …

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Exploring Secondary Metabolite Profiles Of Sloth Algae, Valerie Quach, Paige Smith May 2021

Exploring Secondary Metabolite Profiles Of Sloth Algae, Valerie Quach, Paige Smith

Honors Theses

In this experiment, we investigated the composition of the secondary metabolites in sloth algal cultures. Additionally, we investigated the effects of secondary metabolites in sloth algal cultures on insects. The three outlets of investigation include insect avoidance tests, sending samples to the Natural Center for Natural Products Research, and analyzing sequencing data with AntiSMASH to identify secondary metabolite biosynthetic gene clusters. While our data from the Drosophila fly tests were inconclusive, we found that our samples contain many different gene clusters for terpenes, NRPS, PKS, RiPPs, which are volatile compounds with a wide array of biosynthetic functions. This research can …

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University Of Mississippi 167th Commencement, Class Of 2020, University Of Mississippi, Glenn F. Boyce, Noel E. Wilkin, Patrick Willis May 2021

University Of Mississippi 167th Commencement, Class Of 2020, University Of Mississippi, Glenn F. Boyce, Noel E. Wilkin, Patrick Willis

Commencement Programs

Because of the COVID-19 Pandemic, Commencement Events for the Class of 2020 were postponed until May 2021. Convocation was held in Vaught-Hemingway Stadium on Hollingsworth Field.

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May 4, 2021, University Of Mississippi. Faculty Senate May 2021

May 4, 2021, University Of Mississippi. Faculty Senate

Meeting Minutes

Minutes for the May 2021 meeting of the University of Mississippi Faculty Senate.

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Simian Varicella Virus Antibody Response In Recombinant Svv-Siv Immunized Primates, Kiser Horne May 2021

Simian Varicella Virus Antibody Response In Recombinant Svv-Siv Immunized Primates, Kiser Horne

Honors Theses

Since its emergence in the early 1980’s HIV has killed approximately 32 million people, and continues to kill over half a million people every year. Significant research into potential vaccines and cures for HIV has been ongoing for decades but has been largely unsuccessful. One of the more promising technologies that is being investigated to develop an HIV vaccine is recombinant vaccine technology. The study presented in this thesis aims to use simian varicella virus (SVV) and simian immunodeficiency virus (SIV) to act as a model for recombinant vaccine development. If a recombinant SVV-SIV vaccine can be proven safe and …

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The Functional Connectivity Of The Auditory Cortex In Autism Spectrum Disorder, Katherine Wilson May 2021

The Functional Connectivity Of The Auditory Cortex In Autism Spectrum Disorder, Katherine Wilson

Honors Theses

Disturbance of the auditory cortex in Autism Spectrum Disorder (ASD) is well known as well as its influence on hearing. Functional connectivity within the brain is also known to be affected by ASD. However, functional connectivity of the auditory cortex in ASD has yet to be studied. In this study, using resting-state functional magnetic resonance imaging data from the Autism Brain Imaging Data Exchange (ABIDE), functional connectivity of the auditory cortex was examined by comparing 68 individuals with ASD and 75 individuals with ASD. Four brain regions showed smaller functional connectivity to and from the auditory cortex; the occipital cortex, …

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Chronic Exercise And Memory Interference, Lisa Vogelgesang May 2021

Chronic Exercise And Memory Interference, Lisa Vogelgesang

Honors Theses

This online study examined whether chronic exercise is associated with attenuated memory interference. Sixty-three healthy, young adults completed an interference task (AB/AC-paradigm) and self-reported the number of days and minutes a day they engaged in moderate-to-vigorous physical activity. We found that proactive interference (PI), but not retroactive interference (RI), occurred but none of the exercise modalities significantly impacted PI. Future studies should evaluate whether different interference tasks display diverse sensitivities to exercise-induced changes in memory interference. Moreover, other potential modulating factors, such as the duration and intensity of the exercise should be controlled for.

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Determination Of Metals And Microplastics In Sediment From Oyster Reefs In The Mississippi Sound, Shelby Goza May 2021

Determination Of Metals And Microplastics In Sediment From Oyster Reefs In The Mississippi Sound, Shelby Goza

Honors Theses

This research centers on the determination of metals (Cd, Pb, V, Cr, Mn, Fe, Co, Ni, Cu) and microplastics (MPs) in marine sediment from oyster reefs in the Mississippi Sound Estuary. Oysters (Crassostrea virginica) are a vital part of the Gulf Coast economy, but their population has dramatically declined in recent years due to multiple stressors, including oil spills and fluctuations in salinity from flooding. Increasingly frequent flooding events also introduce high loads of MPs and sediments containing heavy metals from the Mississippi River. These pollutants can have deleterious effects on oyster biology; however, they have not been adequately …

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