Digital Commons Network^™

A Historical And Contextual Analysis Of Soviet And Russian "Active Measures": How Russian Political Warfare Efforts In Foreign Presidential Elections Have Transformed In The Information Age, Olivia Myers

Honors Theses

This thesis seeks to analyze the transformation of Russian active measures in targeted national elections since the Soviet era. Through a historical analysis of research on active measures and contextual analysis of active measures campaigns themselves, this thesis finds that Russian active measures techniques have not drastically changed since the Soviet era. Instead, as a result of technology, Russian active measures have utilized platforms of social media to become more targeted, continuous, and convert. Therefore, Russian active measures campaigns have been better able to successfully target specific audiences, arguably making these campaigns more effective.

Analysis Of Multigenerational Behavioral Effects Of Dietary Benzo[A]Pyrene Exposure In Adult Zebrafish, Mary Beth Gillespie

Honors Theses

Benzo[a]pyrene (BaP) is a polycyclic aromatic hydrocarbon that is linked to negative reproductive and developmental effects in humans and animals. Because BaP is carcinogenic, and its continued presence in the environment allows it to be inhaled and ingested, better understanding of the effects of BaP is needed. To determine the behavioral effects of BaP exposure, zebrafish were used as a model. Wild-type zebrafish (5D) underwent two separate 21-day dietary exposures to 2.5 and 25 μg BaP/g fish to compare how BaP exposure affects locomotor activity. Following the dietary exposure, fish were mated to obtain and raise the F1 generation to …

Predator-Prey Interactions Between Escherichia Coli Strains And Caenorhabditis Elegans At Various Temperatures And Resource Levels, Elizabeth Haynes Whitaker

Honors Theses

Predation is an important component of both evolutionary and ecological interactions across nature. The predator-prey relationship can be altered by differential species’ responses to changes in abiotic factors. The purpose of this study was to examine the effect of temperature, resource levels, and their potential interactions using two strains of Escherichia coli prey and a Caenorhabditis elegans predator. It is concluded that an interaction exists between temperature and resource level on this predator-prey relationship however further testing must be done to confirm results due to contamination in the results.

Early Intervention Service Delivery Models In Mississippi: A Cost-Effectiveness Analysis, Claire Harper

Honors Theses

Purpose: The purpose of the present study was to compare two models of service delivery for early intervention in Mississippi from a health care sector perspective: (1) face-to-face therapy in the home environment and (2) a hybrid model (i.e., telepractice and face-to-face therapy in the home environment), in order to compare costs and determine the most cost-effective service delivery of early intervention.

Methods: Children (n = 10) were recruited and determined to qualify for early intervention services through the Mississippi First Steps Early Intervention program. One early intervention provider, a certified SLP, from the northern health region provided early intervention …

The Rates Of Caries Prevalence By Sex And Age From Individuals In St. Mary Graces And East Smithfield Cemeteries, Elizabeth Houston, Joseph Upton

Honors Theses

Caries are a common pathology in past and current populations, and because of the close interaction of dentition with diet, archaeologists are able to infer components of a population’s culture from pathology like caries (Lanfranco & Eggers, 2010). Most literature implies that women have higher rates of caries than men because of cultural practices and natural physiological differences which are thought to put women at an increased risk (Lukacs, 2008). Another established trend throughout literature is that caries prevalence tends to increase with age, regardless of sex (Hillson, 2008). We evaluated data from the East Smithfield (1348-1350 AD) and Saint …

Covalent Modification Of Genetically Engineered Polymers With Bodipy Fluorophores, Emilie Smith

Honors Theses

Osteoarthritis and other debilitating diseases cause chronic pain that is difficult to manage. Nonsteroidal Anti-inflammatory Drugs (NSAIDs) are the current standard of treatment for many long-term pain management, but there are potential systemic effects when using NSAIDs long-term. Therefore, it isnecessary to have an alternative option for NSAID delivery that doesn’t include these systemic effects. Hydrogels can be that alternative option. Hydrogels’ distinct characteristics allow them to be viable in the body, degrade under unique conditions, and be modified through many different chemistries. Additionally, hydrogels can be engineered and their properties optimized for the use as a drug depot inside …

End Group Modification Of Linear Dendritic Block Copolymers (Ldbcs), Chinwe Udemgba

Honors Theses

Linear dendritic block copolymers are amphiphilic molecules that consist of a dendritic hydrophilic portion and a linear hydrophobic portion. Its unique ability to self-assemble into spherical nanoaggregates while having the potential to uptake and transport both hydrophilic and hydrophobic drugs makes these polymers an item of interest in regard to the drug delivery field. The synthesis of polyamidoamine-polylactide linear dendritic block copolymers was designed to address the common issues in drug delivery systems, including problems in permeability, solubility, stability, specificity, and retention. Though this linear dendritic block copolymer has previously been synthesized in our lab with cationic amine surface functionalities, …

Handfuls Of Sea Glass, Blair Madison

Honors Theses

HANDFULS OF SEA GLASS: A fiction novella that explores the themes of grief, friendship, and love through two high-school seniors, Denver and Eli, after they lose Amelia, their best friend and sister (respectively). (Under the direction of Beth Spencer)

Responses Of The Carnivorous Pink Spoonleaf Sundew (Drosera Capillaris) To Nitrogen Addition, Phosphorus Addition, And Simulated Fire, Karina Rodriguez Castillo

Honors Theses

This study investigated how the carnivorous plant, Drosera capillaris(pink sundew), responded to changes in the resources of its habitat, the fire-prone, nutrient-poor wet savannas. It is of interest to determine what soil nutrient(s), nitrogen or phosphorus, limits the survival and growth of pink sundew, and to what extent, if any, does fire affect the survival and growth of this carnivorous plant. My field experiments had twenty plots with two replicate groups consisting of four pink sundews in each plot. From the fall of 2017 to the fall of 2019, only half of the plots were clipped annually, and there …

Systematic Review Of Race/Ethnicity In Parkinson's Disease, Amia Fisher

Honors Theses

The goal of this study was to examine race/ethnicity with an emphasis on African Ancestry in Parkinson’s Disease (PD) through a systematic review. Out of 448 scholarly articles that were originally extracted from the search, 445 were excluded due to their irrelevance regarding race/ethnicity and African ancestry in PD. Three scholarly articles were obtained through a PubMed/MEDLINE search for the review. Amongst the three sources that were chosen, there were more than 450,000 participants with PD that ranged in ages 40-65+; each case of PD within these studies were reported from 1993-2005. The varying races/ethnicities of White/non-Hispanic White, Black/African American, …

Explanatory Models Of Autism In Nigeria: Exploring Sociocultural Beliefs To Inform Systems Of Care, Gabrielle Udoka Robertson

Honors Theses

Advancements in the diagnosis, understanding, and treatment of individuals with autism spectrum disorder (ASD) have yet to benefit children and families struggling with ASD in Nigeria and other African countries. Not only is there a scarcity of research on ASD in sub- Saharan Africa, but also a lack of mental health and special education services and a lack of understanding of the sociocultural considerations that must inform culturally responsive care. As such, this study explored the sociocultural conceptualizations of autism spectrum disorder (ASD) in Nigeria and how these conceptualizations affect the experiences and care of people with autism. The unique …

Diagnostic Approaches To Combat Antibiotic Resistance In Bacteria, Alexander Oliveri, Shade Smith, Anshul Anugu

Honors Theses

The threat of antibiotic resistance is a major problem faced by the healthcare field affecting millions of people and costing tens of thousands of lives annually. Of the potential ways to mitigate this issue the field of antibiotic resistance testing presents an opportunity for significant improvement and benefits. Several methods of such diagnostic processes can yield more informative results than the current commonly used Kirby-Bauer test. However, there are benefits and limitations to each method. In the context of a clinically relevant diagnostic for antibiotic resistance, the microarray platform exhibits the necessary breadth with opportunities to overcome some limitations with …

"The Unhappy Class Of Females": An Examination Of Non-Elite White Women In The Civil War-Era South, Reagan Elizabeth Whittington

Honors Theses

This thesis focuses on the perceptions and realities of non-elite white women in the South and how their lives and expectations changed from the antebellum years to the end of Reconstruction. There were many secondary sources consulted both before and during the research process for this thesis, and these sources are listed, alongside their significance, in the introduction. Most of the primary sources referenced for this thesis were newspapers printed in the South between 1850 and 1877, but United States census data and public records were also consulted. This thesis investigates how non-elite white women were expected to behave by …

Purification Of Pcbp2 And Its Effect On The Formation Of Dna I-Motifs And Secondary Structures, Nathan Redden

Honors Theses

Several secondary, non-B forms of DNA are associated with the promoter regions of many oncogenes, including the intensely studied c-MYC gene that codes for a transcription factor. Two such secondary structures, G-quadruplexes, and i-motifs, have become topics of interest due to their prevalence within oncogenic promoters, as well as their potential accessibility for drug targeting. B-form DNA can adopt alternative structures under certain conditions. These alternative structures are favored when there is an asymmetric distribution of guanosine and cytosine on complimentary DNA strands. The strand rich in guanosine is able to form a quadruple stranded DNA complex termed a G-quadruplex. …

Applications Of Sodium Azide In The Synthesis Of Tetrazines And Hydrolysis Reactions, My Le

Honors Theses

The inverse electron demand Diels−Alder cycloadditions of heterocyclic azadienes have provided a robust methodology for synthesizing highly substituted and functionalized heterocycles. It is widely used in organic synthesis and the pharmaceutical industry in the divergent construction of screening libraries and bioorthogonal conjugation. Each heterocyclic azadiene was found to possess a unique reactivity toward different classes of dienophiles, display predictable modes of cycloaddition, and exhibit substantial substituent electronic effects impacting their intrinsic reactivity and cycloaddition regioselectivity. Synthesis of 1,2,4,5-tetrazine has been reported in the literature since the late 19th century, showing scientists' tremendous interest in its application.

Herein we attempt to …

The Effect Of Advocate Disclosure On The Perceptions Of A Young Adult Who Stutters, Madeline Simpson

Honors Theses

This between-group study designed weighed the effects of stuttering disclosure on the perceptions of a 17-year-old male who stutters, relative to perceived speech skills and personality characteristics. 1225 participants were included in the dataset analysis with a balanced distribution across all ranges. The conditions used in this study include (1) control condition (no disclosure), as well as experimental conditions including: (2) father disclosure, (3) male coach disclosure, (4) female teacher disclosure, (5) girlfriend disclosure, and (6) female speech-language pathologist. Participants in the control group only viewed the primary video stimulus, while participants in the experimental groups viewed one of the …

Effects Of Crowding Agents On I-Motif Dna, Hayden Brines

Honors Theses

Deoxyribonucleic acid (DNA) is a well-known double stranded, helical, biological molecule. In addition to its more commonly known structure, DNA can also form more complicated structures like G-quadruplexes and i-motifs (iM). The iMs are formed by cytosine rich DNA and are a four stranded structure that is typically looped around itself. The iM formation is typically pH-dependent and is favored in more acidic conditions; the pKa value is approximately 6.5. This pKa value allows for potential in vivo formation, since the cells have a pH of approximately 7.3. Due to this, iMs are thought to be powerful, innovative molecules for …

The Interhemispheric Connectivity Of The Auditory Cortices, Taylor Stansberry

Honors Theses

Objectives: The corpus callosum of the brain is an important and complex structure that allows communication between the two cerebral hemispheres. In the absence of knowledge about the relationship between the corpus callosum and the auditory cortices, this study aimed to investigate how the structure changes. Specifically, we explored the age associated changes of interhemispheric connectivity between left and right cortices through the corpus callosum.Methods: Using Diffusion Tensor Imaging (DTI) data from enhanced Nathan Kline Institute- Rockland Sample (NKI-RS), we isolated the auditory corpus callosum, or the section of the corpus callosum that transfers auditory information, in each individual subject …

Chemical And Co-Solute Effects Of Polyethylene Glycol On I-Motif Formation, Lindsey Rutherford

Honors Theses

DNA typically forms Watson and Crick double helix structures in which adenine, thymine, guanine, and cytosine pair with their complimentary DNA base. However, DNA i-motif structures can form in cytosine rich DNA, typically under slightly acidic conditions (~pH 6). DNA i-motifs are four stranded secondary structures in which cytosine pairs with cytosine to form a quadruplex. The i-motifs are typically formed in acidic conditions because of the protonation in the C•C base pair between one of the three hydrogen bases. Recent studies have suggested i-motifs can also form under neutral conditions, which is more realistic for a cell. It is …

Has Maize Overtaken Our Reality? A Personal Briefing, Biochemical Comparison, Agrigenomics, And History Of Maize, Nader Pahlevan

Honors Theses

Maize (Zea mays ssp. Mays) is a revolutionary cereal grain that has raced to the world’s most popular staple crop, transforming societies and impacting history. This paper aims to build and portray the story maize has created through its journey to world domination. The important details that encompass this literature are maize’s cultural significance in my life’s story, the comparison of various starches broken down into amylose and amylopectin ratios, a summative historical account on maize’s spread throughout numerous parts of the old world, and the genetical analysis of maize that explains the key features that have led …

Composition And Oxidative Potential Of Fine Particulate Matter From Pascagoula, Ms, Madison Smith

Honors Theses

Air pollution is one of the top-ranking risk factors for death and disability around the world, accounting for nearly 4.9 million deaths worldwide (State of Global Air, 2019). Specifically, fine particulate matter (PM_2.5) has been linked to many adverse effects on human health, yet there is very little known about what characteristics exactly cause these adverse health effects and how they cause them. Samples for this study were collected from Pascagoula, MS, a small town located on the Mississippi Gulf Coast that is home to many industrial yards, from September 2013 to December 2013. Black carbon (BC) analysis …

Bringing Biochemistry Home: Transforming Milk Into Yogurt, Ashley King

Honors Theses

Communicating the beauty and complexity of biochemistry to students in a large classroom during the pandemic: what a challenge! We undertook a novel endeavor in the Department of Chemistry and Biochemistry by introducing a mandatory kitchen chemistry experiment in a lecture course. Milk, the epitome of our identity as mammals, also contains all of the major biochemical macromolecules studied in Biochemistry I. Further, the making of yogurt invokes physical processes that are the major processes and molecular forces that dominate the content of the course. Here, we report the results of massive parallel experiment conducted in the kitchens of the …

Coronary Artery Disease: An Analysis Of Its Biochemical, Physiological, And Sociological Causes And Effects, Alexander Velazquez

Honors Theses

Coronary Artery Disease (CAD) is a serious condition caused by a buildup of plaque in your coronary arteries, the blood vessels that bring oxygen-rich blood to your heart. It disproportionately affects millions of Americans and thousands of Mississippians. This study presents the results of an evaluation of causation factors of CAD, the physiological impact on the body, and the contributing determinants of CAD on Mississippi populations. Data on Mississippi populations were collected using the Center for Population Studies at the University of Mississippi. A multitude of individuals were evaluated when examining the causes and effects of CAD including men, women, …

Enantioselective Interactions Of Anti-Infective 8-Aminoquinoline Therapeutics With Human Monoamine Oxidases A And B, Narayan D. Chaurasiya, Haining Liu, Robert J. Doerksen, N. P. Dhammika Nanayakkara

Faculty and Student Publications

8-Aminoquinolines (8-AQs) are an important class of anti-infective therapeutics. The monoamine oxidases (MAOs) play a key role in metabolism of 8-AQs. A major role for MAO-A in metabolism of primaquine (PQ), the prototypical 8-AQ antimalarial, has been demonstrated. These investigations were further extended to characterize the enantioselective interactions of PQ and NPC1161 (8-[(4-amino-1-methylbutyl) amino]-5-[3, 4-dichlorophenoxy]-6-methoxy-4-methylquinoline) with human MAO-A and-B. NPC1161B, the (R)-(−) enantiomer with outstanding potential for malaria radical cure, treatment of visceral leishmaniasis and pneumocystis pneumonia infections is poised for clinical development. PQ showed moderate inhibition of human MAO-A and-B. Racemic PQ and (R)-(−)-PQ both showed marginally greater (1.2-and …

Hiv-1 Tat Protein Promotes Neuroendocrine Dysfunction Concurrent With The Potentiation Of Oxycodone’S Psychomotor Effects In Female Mice, Mohammed F. Salahuddin, Fakhri Mahdi, Suresh P. Sulochana, Jason J. Paris

Faculty and Student Publications

Human immunodeficiency virus (HIV) is associated with neuroendocrine dysfunction which may contribute to co-morbid stress-sensitive disorders. The hypothalamic-pituitary-adrenal (HPA) or-gonadal (HPG) axes are perturbed in up to 50% of HIV patients. The mechanisms are not known, but we have found the HIV-1 trans-activator of transcription (Tat) protein to recapitulate the clinical phenotype in male mice. We hypothesized that HPA and/or HPG dysregulation contrib-utes to Tat-mediated interactions with oxycodone, an opioid often prescribed to HIV patients, in females. Female mice that conditionally-expressed the Tat1–86 protein [Tat(+) mice] or their counter-parts that did not [Tat(−) control mice] were exposed to forced swim …

Pharmacy Matters - May 2021, University Of Mississippi. School Of Pharmacy

Pharmacy Matters Newsletters

Featured stories: "Distinguished Alumni Recognized during Alumni Weekend," "Pharmacy Student Named UM Hall of Fame Inductee," "UM Vaccination Site Servers Community through Care"

University Of Mississippi 168th Commencement, Class Of 2021, University Of Mississippi, Glenn F. Boyce, Noel E. Wilkin, Jonathan T. M. Reckford

Commencement Programs

No abstract provided.

Starting A New Tradition - Journey To Commencement, Whitney Tarpy

Journey to Commencement

Rasha Elkanayati becomes inaugural graduate of new industrial pharmacy program

Construction And Analysis Of Three Multi-Partite Synthetic Microbial Communities, Alexander J. Lazzara, Jacob K. Fanning

Honors Theses

Microbial Communities are of interest to molecular biologists hoping to understand the nature of metabolic interactions between co-existing, or possibly mutualistic, organisms. These interactions are ubiquitous in nature, but understanding the molecular mechanisms involved remains challenging and not well understood. Here, we design three tri-partite microbial circuits based on possible interactions among involved microbes, which are discussed and may suggest mutualistic interactions. Carbon and nitrogen molecular pathways and the intracellular metabolism of each microbe is discussed. We present minimal growth media that will ensure that organisms utilize available resources, which may originate from metabolic processes in neighboring microbes, simulating a …

Molecular Mechanisms Of Oxidative Stress On Molecular Motors, Addison Caspari-Linhardt

Honors Theses

Astronauts encounter many forms of ionizing radiation during space travel. Ionizing radiation has been seen to cause cancer, cataracts, radiation sickness, tissue damage, hereditary effects, and damage to the central nervous system. Ionizing radiation can damage DNA molecules through oxidation, as well as other vital proteins like molecular motors. Kinesin-1 is a molecular motor protein that essential to intracellular transport. Microtubules serve as the “roadway” for kinesin transport, where kinesin converts chemical energy from ATP hydrolysis into mechanochemical “steps” to move along the microtubules. Optical trapping has been used in previous research to measure single kinesin motor properties. We have …