Digital Commons Network^™

Tissue-Specific Regulation Of Hnk-1 Biosynthesis By Bisecting Glcnac, Haruka Kawade, Jyoji Morise, Sushil K. Mishra, Shuta Tsujioka

Faculty and Student Publications

Human natural killer—1 (HNK-1) is a sulfated glyco-epitope regulating cell adhesion and synaptic functions. HNK-1 and its non-sulfated forms, which are specifically expressed in the brain and the kidney, respectively, are distinctly biosynthesized by two homologous glycosyltransferases: GlcAT-P in the brain and GlcAT-S in the kidney. However, it is largely unclear how the activity of these isozymes is regulated in vivo. We recently found that bisecting GlcNAc, a branching sugar in N-glycan, suppresses both GlcAT-P activity and HNK-1 expression in the brain. Here, we observed that the expression of non-sulfated HNK-1 in the kidney is unexpectedly unaltered in mutant mice …

The Minimum Effective Training Dose Required For 1rm Strength In Powerlifters, Patroklos Androulakis-Korakakis, Nick Michalopoulos, James P. Fisher, Justin Keogh, Jeremy P. Loenneke, Eric Helms, Milo Wolf, Greg Nuckols, James Steele

Faculty and Student Publications

The aim of this multi-experiment paper was to explore the concept of the minimum effective training dose (METD) required to increase 1-repetition-maximum (1RM) strength in powerlifting (PL) athletes. The METD refers to the least amount of training required to elicit meaningful increases in 1RM strength. A series of five studies utilising mixed methods, were conducted using PL athletes & coaches of all levels in an attempt to better understand the METD for 1RM strength. The studies of this multi-experiment paper are: an interview study with elite PL athletes and highly experienced PL coaches (n = 28), an interview and survey …

University Community Remembers Luther August Knight Jr., Edwin B. Smith

University of Mississippi News

Beloved biology professor helped establish UM Field Station, conducted groundbreaking research

New Faculty, 2021-2022, University Of Mississippi. Provost

New Faculty

No abstract provided.

Orsp Nsf Epscor Rii Track-2 Information Session: Industries Of The Future – 2022, Jason Hale

ORSP Presentations

Overview of the NSF solicitation for this program for the 2022 competition year; ORSP process for managing the limited submission; and UM a few UM resources available to contribute to proposals.

Helping Farms Be In Harmony With Nature, Shea Stewart

University of Mississippi News

EPA grant involves researchers, Mississippi Delta farmers exploring agricultural runoff water

August 23, 2021, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Newsletter Fall/Winter 2021, Annette Kluck, Margaret Savoie

Newsletters of the Graduate School

No abstract provided.

Heteroacene-Based Amphiphile As A Molecular Scaffold For Bioimaging Probes, Tharindu A. Ranathunge, Mahesh Loku Yaddehige, Jordan H. Varma, Cameron Smith, Jay Nguyen, Iyanuoluwani Owolabi, Wojciech Kolodziejczyk, Nathan I. Hammer, Glake Hill, Alex Flynt, Davita L. Watkins

Faculty and Student Publications

The challenges faced with current fluorescence imaging agents have motivated us to study two nanostructures based on a hydrophobic dye, 6H-pyrrolo[3,2-b:4,5-b’]bis [1,4]benzothiazine (TRPZ). TRPZ is a heteroacene with a rigid, pi-conjugated structure, multiple reactive sites, and unique spectroscopic properties. Here we coupled TRPZ to a tert-butyl carbamate (BOC) protected 2,2-bis(hydroxymethyl)propanoic acid (bisMPA) dendron via azide-alkyne Huisgen cycloaddition. Deprotection of the protected amine groups on the dendron afforded a cationic terminated amphiphile, TRPZ-bisMPA. TRPZ-bisMPA was nanoprecipitated into water to obtain nanoparticles (NPs) with a hydrodynamic radius that was comparison, TRPZ-PG was encapsulated in pluronic-F127 (Mw = 12 kD), a polymer surfactant …

Umhs Teacher Named 2021 Outstanding Earth And Space Science Teacher, Pam Starling

University of Mississippi News

Gail Davis honored by the National Association of Geoscience Teachers

Temporal And Spatial Variations In Three-Dimensional Seismic Oceanography, Zheguang Zou, Parsa Bakhtiari Rad, Leonardo Macelloni, Likun Zhang

Faculty and Student Publications

Seismic oceanography is a new cross-discipline between geophysics and oceanography that uses seismic reflection data to image and study the oceanic water column. Previous work on seismic oceanography was largely limited to two-dimensional (2D) seismic data and methods. Here we explore and quantify temporal and spatial variations in three-dimensional (3D) seismic oceanography to address whether 3D seismic imaging is meaningful in all directions and how one can take advantage of the variations. From a 3D multichannel seismic survey acquired for oil and gas exploration in the Gulf of Mexico over a 6-month period, a 3D oceanic seismic volume was derived. …

Tracking The Amide I And Αcoo− Terminal Ν(C=O) Raman Bands In A Family Of L-Glutamic Acid-Containing Peptide Fragments: A Raman And Dft Study, Ashley E. Williams, Nathan I. Hammer, Ryan C. Fortenberry, Dana N. Reinemann

Faculty and Student Publications

The E-hook of β-tubulin plays instrumental roles in cytoskeletal regulation and function. The last six C-terminal residues of the βII isotype, a peptide of amino acid sequence EGEDEA, extend from the microtubule surface and have eluded characterization with classic X-ray crystallographic techniques. The band position of the characteristic amide I vibration of small peptide fragments is heavily dependent on the length of the peptide chain, the extent of intramolecular hydrogen bonding, and the overall polarity of the fragment. The dependence of the E residue’s amide I ν(C=O) and the αCOO− terminal ν(C=O) bands on the neighboring side chain, the length …

Tracking The Amide I And Αcoo− Terminal Ν(C=O) Raman Bands In A Family Of L-Glutamic Acid-Containing Peptide Fragments: A Raman And Dft Study, Ashley E. Williams, Nathan I. Hammer, Ryan C. Fortenberry, Dana N. Reinemann

Faculty and Student Publications

The E-hook of β-tubulin plays instrumental roles in cytoskeletal regulation and function. The last six C-terminal residues of the βII isotype, a peptide of amino acid sequence EGEDEA, extend from the microtubule surface and have eluded characterization with classic X-ray crystallographic techniques. The band position of the characteristic amide I vibration of small peptide fragments is heavily dependent on the length of the peptide chain, the extent of intramolecular hydrogen bonding, and the overall polarity of the fragment. The dependence of the E residue’s amide I ν(C=O) and the αCOO− terminal ν(C=O) bands on the neighboring side chain, the length …

The Degree Of Polymerization And Sulfation Patterns In Heparan Sulfate Are Critical Determinants Of Cytomegalovirus Entry Into Host Cells, Dipanwita Mitra, Mohammad H. Hasan, John T. Bates, Michael A. Bierdeman

Faculty and Student Publications

Several enveloped viruses, including herpesviruses attach to host cells by initially interacting with cell surface heparan sulfate (HS) proteoglycans followed by specific coreceptor engagement which culminates in virus-host membrane fusion and virus entry. Interfering with HS-herpesvirus interactions has long been known to result in significant reduction in virus infectivity indicating that HS play important roles in initiating virus entry. In this study, we provide a series of evidence to prove that specific sulfations as well as the degree of polymerization (dp) of HS govern human cytomegalovirus (CMV) binding and infection. First, purified CMV extracellular virions preferentially bind to sulfated longer …

(E)-2,6,10-Trimethyldodec-8-En-2-Ol: An Undescribed Sesquiterpenoid From Copaiba Oil, Mohammed F. Hawwal, Zulfiqar Ali, Mei Wang, Jianping Zhao

Faculty and Student Publications

The use of copaiba oil has been reported since the 16th century in Amazon traditional medicine, especially as an anti-inflammatory ingredient and for wound healing. The use of copaiba oil continues today, and it is sold in various parts of the world, including the United States. Copaiba oil contains mainly sesquiterpenes, bioactive compounds that are popular for their positive effect on human health. As part of our ongoing research endeavors to identify the chemical constituents of broadly consumed herbal supplements or their adulterants, copaiba oil was investigated. In this regard, copaiba oil was subjected to repeated silica gel column chromatography …

Red Algal Sulfated Galactan Binds And Protects Neural Cells From Hiv-1 Gp120 And Tat, Vitor H. Pomin, Fakhri Mahdi, Weihua Jin, Fuming Zhang

Faculty and Student Publications

The potential neuroprotective capacity of four different sulfated glycans: Botryocladia occidentalis-derived sulfated galactan (BoSG) (MW > 100 kDa), Lytechinus variegatus-derived sulfated fucan (LvSF) (MW~90 kDa), high-molecular weight dextran sulfate (DxS) (MW 100 kDa), and unfractionated heparin (UFH) (MW~15 kDa), was assessed in response to the HIV-1 proteins, R5-tropic glycoprotein 120 (gp120) and/or trans-activator of transcription (Tat), using primary murine neurons co-cultured with mixed glia. Compared to control-treated cells in which HIV-1 proteins alone or combined were neurotoxic, BoSG was, among the four tested sulfated glycans, the only one capable of showing significant concentration-dependent neuroprotection against Tat and/or gp120, alone or combined. …

Sulfur Isotopes As A Proxy For Human Diet And Mobility From The Preclassic Through Colonial Periods In The Eastern Maya Lowlands, Claire E. Ebert, Asta J. Rand, Kirsten Green-Mink, Julie A. Hoggarth, Carolyn Freiwald, Jaime J. Awe, Willa R. Trask, Jason Yaeger, M. Kathryn Brown, Christophe Helmke, Rafael A. Guerra, Marie Danforth, Douglas J. Kennett

Faculty and Student Publications

Maya archaeologists have long been interested in understanding ancient diets because they provide information about broad-scale economic and societal transformations. Though paleodietary studies have primarily relied on stable carbon (δ13C) and nitrogen (δ15N) isotopic analyses of human bone collagen to document the types of food people consumed, stable sulfur (δ34S) isotope analysis can potentially provide valuable data to identify terrestrial, freshwater, or marine/coastal food sources, as well as determine human mobility and migration patterns. Here we assess applications of δ34S for investigating Maya diet and migration through stable isotope analyses of human bone collagen (δ13C, δ15N, and δ34S) from 114 …

Issue 375: July 29-August 19,2021, The Local Voice

The Local Voice

No abstract provided.

Cafer Named Director Of Center For Population Studies, Edwin B. Smith

University of Mississippi News

Expert overseeing census, other data important to meeting research needs

Nsf Grfp Information Session, Jason Hale

ORSP Presentations

NSF Graduate Research Fellowship Program (GRFP) Information Sessions

• Jason Hale, M.S., Director of Research Development, ORSP
• Robert Doerksen, Ph.D., Associate Dean of the Graduate School
• Vivian Ibrahim, Ph.D., Associate Professor of History; Director of the Office of National Scholarship Advisement

with Annette Kluck, Nikki Reinemann-Gross, Thomas Werfel, Cole Stevens, Courtney Roper, Rachel Greenspan, & Hoang V. Le

Poster 5, Alicja Urbaniak

Drug Discovery and Development Colloquium

No abstract provided.

Poster 9, Nicole Vita

Drug Discovery and Development Colloquium

No abstract provided.

Poster 3, Noemí Martínez Conde

Drug Discovery and Development Colloquium

No abstract provided.

Poster 4, John Gaydos

Drug Discovery and Development Colloquium

No abstract provided.

Poster 7, Rohini Dwivedi

Drug Discovery and Development Colloquium

No abstract provided.

Th2/Th1 Cytokine Imbalance Is Associated With Higher Covid-19 Risk Mortality, Ana B. Pavel, Jacob W. Glickman, James R. Michels, Seunghee Kim-Schulze, Rachel L. Miller, Emma Guttman-Yassky

Faculty and Student Publications

A major component of COVID-19 severe respiratory syndrome is the patient’s immune response to the SARS-CoV-2 virus and the consequential multi-organ inflammatory response. Several studies suggested a potential role of CD4+ T cells in COVID-19 severe respiratory syndrome. We first hypothesized that there is a type 2 helper (Th2)/type 1 helper (Th1) imbalance in older age, male, asthma, smokers, and high ACE2 expression phenotype in the airway of non-infected patients. Next, we hypothesized that a Th2/Th1 imbalance may predict higher mortality in COVID-19 infected hospitalized patients with and without patient reported current asthma. We first analyzed publicly available gene expression …

Poster 04, Sukanya Pati

Drug Discovery and Development Colloquium

No abstract provided.

Poster 05, Robert Fogle

Drug Discovery and Development Colloquium

No abstract provided.

Poster 09, Narsimha Penthala

Drug Discovery and Development Colloquium

No abstract provided.

Poster 08, Seon Beom Kim

Drug Discovery and Development Colloquium

No abstract provided.