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Application Of Fluorinated Reagents In Synthesis And Drug Discovery, Amna T. Adam Jan 2020

Application Of Fluorinated Reagents In Synthesis And Drug Discovery, Amna T. Adam

Electronic Theses and Dissertations

ABSTRACT The introduction of fluorine or fluorine containing moieties in pharmaceuticals may increase metabolic stability, binding affinity, bioavailability, lipophilicity, selectivity for targets, and fluorine-labelled groups can be used as imagining probes, i.e. in positron emission tomography (PET). Within the past decade, approximately 20% of all marketed pharmaceuticals contain fluorine and in 2018 alone 36% of the top 50 selling drugs on the market contained one or more fluorine atoms. Fluorinated reagents also plays an important role in the development of methods to introduce unique groups into an organic molecule, such as fluorination and methylenation. In this work, the scope of …


Mscpa Centennial History: A Century Of Cpas In Mississippi, James W. Davis, Dale L. Flesher, Annette Pridgen, Mississippi Society Of Certified Public Accountants Jan 2020

Mscpa Centennial History: A Century Of Cpas In Mississippi, James W. Davis, Dale L. Flesher, Annette Pridgen, Mississippi Society Of Certified Public Accountants

Publications of Accounting Associations, Societies, and Institutes

No abstract provided.


Development Of An Ophthalmic Nanoemulsion Topical Formulation For Corneal Wound Healing, Chuntian Cai Jan 2020

Development Of An Ophthalmic Nanoemulsion Topical Formulation For Corneal Wound Healing, Chuntian Cai

Electronic Theses and Dissertations

Corneal wound healing is a complex process involving cell death, migration, proliferation, differentiation, extracellular matrix remodeling and a various of growth factors. Of these factors, interleukin-1 and transforming growth factor beta allow the effectiveness of cell migration and tissue repair. Current management advocates multiple therapies aimed to prevent inflammation, avoid the fibrosis. Pirfenidone (PFD) has recently been investigated for its anti-fibrotic effect. The current study was undertaken to develop and optimize PFD-loaded nanoemulsion (NE; PFD-NE) which could increase the drug load and the duration of activity. Hot homogenization and probe sonication methods were used for the preparation of PFD-NEs, sesame …


Resonant Ultrasound Spectroscopy Studies Of Poroelasticity In Porous Ceramics And Elasticity Of Thermoelectric Snse, Ashoka Karunarathne Jan 2020

Resonant Ultrasound Spectroscopy Studies Of Poroelasticity In Porous Ceramics And Elasticity Of Thermoelectric Snse, Ashoka Karunarathne

Electronic Theses and Dissertations

This dissertation primarily focuses on use of resonant ultrasound spectroscopic (RUS) measurements to investigate temperature- and pressure-dependent elastic properties of select materials: porous ceramics, which are used in a wide range of material applications, and thermoelectric tin selenide (SnSe), which is widely studied as an efficient thermoelectric material. RUS experiments were conducted on: ceramics used in LG fuel cells, alumina, zircona and titania, to explore their elastic behavior under the variation of hydrostatic pressure over the low- and high-pressure regimes (0.02 – 800 psi). All the porous ceramics exhibited a reversible material softening mechanism with increasing hydrostatic pressure. The comparison …


Determining The Effectiveness Of Rock Mass Classification Schemes When Used To Derive Empirical Predictions For Rock Mass Deformation Modulus, Tanner Cecil Avery Jan 2020

Determining The Effectiveness Of Rock Mass Classification Schemes When Used To Derive Empirical Predictions For Rock Mass Deformation Modulus, Tanner Cecil Avery

Electronic Theses and Dissertations

Normal deformation modulus of rock masses (Erm) is a critical design parameter for any permanent excavation and infrastructure project that requires limited or controlled deformations to ensure performance of permanent support systems and of foundations. Despite being a key parameter, the optimal methods for determining Erm is still debated. These methods can be put into three categories: in-situ tests, empirical solutions, and numerical solutions. Current efforts to derive empirical predictions rely on rock mass classification schemes (RMCS) with the assumption that all RMCS are similarly effective at predicting Erm. Since different RMCS use different sets of variables this assumption does …


Mississippi Teachers Who Are Nationally Board Certified Or Those With Advanced Degrees: Effects On Student Achievement, Amy Tate Barnett Jan 2020

Mississippi Teachers Who Are Nationally Board Certified Or Those With Advanced Degrees: Effects On Student Achievement, Amy Tate Barnett

Electronic Theses and Dissertations

The purpose of this research study was to determine the interaction effects national board certified teachers (NBCTs) and teachers with advanced degrees (ADs); while considering school accountability levels, had on student achievement. This study examined whether significant differences existed in student achievement between the eight identified groups of teachers and how the factors of NBCT status, AD status, and accountability contributed. The study examined student achievement in grades three through eight on the end-of-the-year state assessments for the 2017-18 school year. This research endeavor relied upon the recruitment of local Mississippi school districts and their willingness to participate and share …


Effective Response To Intervention In Middle School, Angela Mechelle Ellison Jan 2020

Effective Response To Intervention In Middle School, Angela Mechelle Ellison

Electronic Theses and Dissertations

This applied mixed methods program evaluation sought to increase student proficiency in mathematics at a rural middle school in central Mississippi. The program focused on improving student achievement through effective professional development. Quantitative and qualitative data was used to gage the program’s effectiveness. Research supporting an effective Response to Intervention Model, professional learning communities, and teacher development was cited and used to construct the program’s implementation framework.


Differential Semantics, William Michael Cox Jan 2020

Differential Semantics, William Michael Cox

Electronic Theses and Dissertations

Differential Semantics is a theoretical accounting of the semantic complexity found in natural language, particularly that of the academic and literary registers. It addresses natural language semantics in terms of its contribution to the characterization and expression of creative thought, beginning the perception and conceptualization of objective reality, folloby the metacognitive development of idiosemantic connotations in reference to those conceptualizations, and finally, the intuitive process of implication and inference that facilitates the abstraction and communication of thought.


Aproaches To Develop Acyclovir Gastro-Retentive Formulations Using Hot Melt Extrusion Technology, Peilun Zhang Jan 2020

Aproaches To Develop Acyclovir Gastro-Retentive Formulations Using Hot Melt Extrusion Technology, Peilun Zhang

Electronic Theses and Dissertations

The aim of the current study was to prepare and compare acyclovir (ACV) floating gastro-retentive formulations synthesized via hot-melt extrusion (HME) techniques using P-CO2 and sodium bicarbonate. Physical mixtures of ACV (20%, w/w) and HPC EF (70%, 60%, w/w) with HPC MF (10%, w/w) or HPMCAS-LG (10%, w/w) were prepared using a co-rotating twin-screw extruder with a screw configuration shoin Figure 2. P-CO2 was injected into zone 9 of the extruder or NaHCO3 was added (10% w/w) during the extrusion process. In vitro dissolution studies (0.1 N hydrochloric acid medium) demonstrated that the formulations floated on the medium because of …


Diversifying The Pipeline: Barriers That Prevent Teachers Of Color From Entering The Profession, Erica L. Avent Jan 2020

Diversifying The Pipeline: Barriers That Prevent Teachers Of Color From Entering The Profession, Erica L. Avent

Electronic Theses and Dissertations

Every year the number of certified teachers entering the teacher workforce is declining across the nation. This decline affects districts across the country, but it especially affects the students that these districts serve. While there is a decline in teachers overall, there is a severe decline in African American teachers. Non- Caucasian students are the largest demographic of students that attend public schools (Cherng & Halpin, 2016). In 2001, forty percent of the students in public education identified as a student of color (Ladson-Billings, 2005a). At the same time, only twelve percent of teachers were non-Caucasian. For those diverse students …


An Analysis Of Efl Learners’ Foreign Language Anxiety And Their Motivation To Learn English, Maide Beyza Cayli Jan 2020

An Analysis Of Efl Learners’ Foreign Language Anxiety And Their Motivation To Learn English, Maide Beyza Cayli

Electronic Theses and Dissertations

This thesis aims to investigate English-language learners’ foreign language anxiety and their motivations to learn English in an American context. The adapted versions of The Motivation/Attitude Questionnaire (Ozturk 2012), and Foreign Language Anxiety Scale (Horwitz et al 1986) were given to 34 Intensive English Program students at a college in Southeastern United States. The participants in the Advanced and Advanced Plus Level have shown moderate level of Foreign Language Anxiety and Motivation. The results have prevailed that the students with higher proficiency levels have had slightly higher level of motivation. Yet, the participants with a higher level of English proficiency …


Fresh Faces, Familiar Favorites Found At Um Books And Bears, Edwin B. Smith Dec 2019

Fresh Faces, Familiar Favorites Found At Um Books And Bears, Edwin B. Smith

University of Mississippi News

Annual toy distribution for employees' families draws volunteers and recipients


Um Professors Collaborate With Counterparts Through Sec Grant, Shea Stewart Dec 2019

Um Professors Collaborate With Counterparts Through Sec Grant, Shea Stewart

University of Mississippi News

Faculty Travel Program encourages, supports conference partnerships


December 4, 2019, The Daily Mississippian Dec 2019

December 4, 2019, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.


Ti-Stan: Model Comparison Using Thermodynamic Integration And Hmc, R. Wesley Henderson, Paul M. Goggans Dec 2019

Ti-Stan: Model Comparison Using Thermodynamic Integration And Hmc, R. Wesley Henderson, Paul M. Goggans

Faculty and Student Publications

© 2019 by the authors. We present a novel implementation of the adaptively annealed thermodynamic integration technique using Hamiltonian Monte Carlo (HMC). Thermodynamic integration with importance sampling and adaptive annealing is an especially useful method for estimating model evidence for problems that use physics-based mathematical models. Because it is based on importance sampling, this method requires an efficient way to refresh the ensemble of samples. Existing successful implementations use binary slice sampling on the Hilbert curve to accomplish this task. This implementation works well if the model has few parameters or if it can be broken into separate parts with …


A Synthesis And Analysis Of Anhydrous Hydroxide Ion Conducting Polymer Electrolytes, Stanton Heydinger Dec 2019

A Synthesis And Analysis Of Anhydrous Hydroxide Ion Conducting Polymer Electrolytes, Stanton Heydinger

Honors Theses

This project investigates the synthesis and physical properties of polyethylene glycol monomethyl ether (MePEGn where n=3 or 7) based polymer electrolytes. The two polymer electrolytes explored in the experiments were designed from two different MePEG chains that varied in their overall length and degree of polymerization. The first MePEG backbone contained three polymerized ethoxy groups and the second contained seven. Both MePEGn polymers were modified by substituting an imidazolium group in place of the alcohol functional group at the end of the PEG chain. This modification was made to create a polymer electrolyte with an attached positive charge that could …


Agreed-Upon Procedures Engagements; Statement On Standards For Attestation Engagements 19, American Institute Of Certified Public Accountants. Auditing Standards Board Dec 2019

Agreed-Upon Procedures Engagements; Statement On Standards For Attestation Engagements 19, American Institute Of Certified Public Accountants. Auditing Standards Board

AICPA Professional Standards

No abstract provided.


Audit Sampling, December 1, 2019; Audit Guide, American Institute Of Certified Public Accountants (Aicpa) Dec 2019

Audit Sampling, December 1, 2019; Audit Guide, American Institute Of Certified Public Accountants (Aicpa)

Industry Guides (AAGs), Risk Alerts, and Checklists

No abstract provided.


United States Suicide Analysis: 1999-2016, Malynn Clark Dec 2019

United States Suicide Analysis: 1999-2016, Malynn Clark

Honors Theses

The purpose of this thesis is to create information visualizations surrounding suicide trends from 1999-2016 in the United States. The original data was obtained from the Centers for Disease Control and Prevention’s Compressed Mortality Database. This database permits users to download several fields of information regarding deaths for the years given. Using this information, many graphs below show trends and patterns for suicide. One notable trend includes the higher proportion of male to female suicides for all categories explored including: age group, race, and metro/nonmetro status. The goal is to bring awareness and understanding surrounding the suicide epidemic in the …


Where No War Has Gone Before: Outer Space And The Adequacy Of The Current Law Of Armed Conflict, Gemmo Bautista Fernandez Dec 2019

Where No War Has Gone Before: Outer Space And The Adequacy Of The Current Law Of Armed Conflict, Gemmo Bautista Fernandez

Journal of Space Law

No abstract provided.


Azimuthal Asymmetries Of Back-To-Back Π±- (Π0, Η, Π±) Pairs In E+E- Annihilation, H. Li, A. Vossen, H. Aihara, D. M. Asner, V. Aulchenko, T. Aushev, V. Babu, I. Badhrees, A. M. Bakich, J. Bennett, V. Bhardwaj, T. Bilka, J. Biswal, A. Bobrov, M. Bračko, M. Campajola, L. Cao, D. Červenkov, V. Chekelian, A. Chen, B. G. Cheon, H. E. Cho, K. Cho, Y. Choi, S. Choudhury, D. Cinabro, S. Cunliffe, F. Di Capua, S. Di Carlo, T. V. Dong, S. Eidelman, T. Ferber Nov 2019

Azimuthal Asymmetries Of Back-To-Back Π±- (Π0, Η, Π±) Pairs In E+E- Annihilation, H. Li, A. Vossen, H. Aihara, D. M. Asner, V. Aulchenko, T. Aushev, V. Babu, I. Badhrees, A. M. Bakich, J. Bennett, V. Bhardwaj, T. Bilka, J. Biswal, A. Bobrov, M. Bračko, M. Campajola, L. Cao, D. Červenkov, V. Chekelian, A. Chen, B. G. Cheon, H. E. Cho, K. Cho, Y. Choi, S. Choudhury, D. Cinabro, S. Cunliffe, F. Di Capua, S. Di Carlo, T. V. Dong, S. Eidelman, T. Ferber

Faculty and Student Publications

© 2019 authors. Published by the American Physical Society. Published by the American Physical Society under the terms of the "https://creativecommons.org/licenses/by/4.0/" Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI. Funded by SCOAP 3 . This work reports the first observation of azimuthal asymmetries around the thrust axis in e+e- annihilation of pairs of back-to-back charged pions in one hemisphere, and π0 and η mesons in the opposite hemisphere. These results are complemented by a new analysis of pairs of back-to-back charged pions. …


Student Co-Directors Work Against Student Food Insecurity, Meaghan Flores Nov 2019

Student Co-Directors Work Against Student Food Insecurity, Meaghan Flores

University of Mississippi News

With community support, Kate Reinhardt and Holten Moreno lead the UM food bank


Arielle Hudson Named Um's 27th Rhodes Scholar, Meaghan Flores, Andrew M. Abernathy Nov 2019

Arielle Hudson Named Um's 27th Rhodes Scholar, Meaghan Flores, Andrew M. Abernathy

University of Mississippi News

Tunica native becomes university's first African American female to earn coveted scholarship


From Higher Education, Success Stems, Bill Dabney Nov 2019

From Higher Education, Success Stems, Bill Dabney

University of Mississippi News

No abstract provided.


Um Student, Alumna Among Rhodes Scholarship Finalists, Andrew Abernathy, Edwin Smith Nov 2019

Um Student, Alumna Among Rhodes Scholarship Finalists, Andrew Abernathy, Edwin Smith

University of Mississippi News

Arielle Hudson, Chinelo Ibekwe prepare for interview process for prestigious international award


Ten Croft Institute Students Earn Esteemed Scholarships, Shea Stewart Nov 2019

Ten Croft Institute Students Earn Esteemed Scholarships, Shea Stewart

University of Mississippi News

Awards fund the education of UM international studies majors


Education Professor Helps Land $1.37 Million Research Grant, Meaghan Flores Nov 2019

Education Professor Helps Land $1.37 Million Research Grant, Meaghan Flores

University of Mississippi News

National Science Foundation funds science education development project


Um Student Serves On World Food Security Committee, Edwin B. Smith Nov 2019

Um Student Serves On World Food Security Committee, Edwin B. Smith

University of Mississippi News

Rohan Agrawal was one of four U.S. college students selected for meeting in Rome


Renormalization, Rigidity And Universality, Saša Kocić Nov 2019

Renormalization, Rigidity And Universality, Saša Kocić

Dynamical Systems Seminar

Renormalization is a powerful tool in mathematics, which originated in physics, and has led to a Nobel Prize (Wilson 1982) and several Fields medals (e.g. Avila 2014). It is the main tool to approach problems involving self-similarity, universality, or rigidity, as it classifies systems into classes of systems that share a common property (universality) or are in some sense equivalent (rigidity). I will give an introduction to renormalizaton ideas and introduce some current topics of research in dynamical systems and mathematical physics, involving renormalization. The talk will be accessible to graduate students. In particular, I will not assume any prior …


Interface Of Statistics, Computing, And Data Science, Xiaoming Huo Nov 2019

Interface Of Statistics, Computing, And Data Science, Xiaoming Huo

Colloquium

Inference (aka predictive modeling) is in the core of many data science problems. Traditional ap-proaches could be either statistically or computationally efficient, however not necessarily both. The existing principles in deriving these models – such as the maximal likelihood estimation prin-ciple - may have been developed decades ago, and do not take into account the new aspects of the data, such as their large volume, variety, velocity and veracity. On the other hand, many existing empirical algorithms are doing extremely well in a wide spectrum of applications, such as the deep learning framework; however they do not have the theoretical …