Digital Commons Network^™

September 9, 2021, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Growth And Feeding In The Sponge Agelas Tubulata From Shallow To Mesophotic Depths On Grand Cayman Island, Keir J. Macartney, Amelia Clayshulte Abraham, Marc Slattery, Michael P. Lesser

Faculty and Student Publications

On Caribbean coral reefs, sponges are important members of the benthic community and play multiple roles in ecosystem structure and function. They have an important role in benthic-pelagic coupling, consuming particulate organic matter (POM) and dissolved organic matter (DOM) and in turn providing food in the form of sponge biomass or the release of detritus for a variety of coral reef organisms. Throughout the Caribbean, sponges show consistent increases in their abundance and growth rates as depth increases into the mesophotic zone (30–150 m). This has been hypothesized to be driven by bottom-up forces, particularly the increased supply of nitrogen-rich …

Tissue-Specific Regulation Of Hnk-1 Biosynthesis By Bisecting Glcnac, Haruka Kawade, Jyoji Morise, Sushil K. Mishra, Shuta Tsujioka

Faculty and Student Publications

Human natural killer—1 (HNK-1) is a sulfated glyco-epitope regulating cell adhesion and synaptic functions. HNK-1 and its non-sulfated forms, which are specifically expressed in the brain and the kidney, respectively, are distinctly biosynthesized by two homologous glycosyltransferases: GlcAT-P in the brain and GlcAT-S in the kidney. However, it is largely unclear how the activity of these isozymes is regulated in vivo. We recently found that bisecting GlcNAc, a branching sugar in N-glycan, suppresses both GlcAT-P activity and HNK-1 expression in the brain. Here, we observed that the expression of non-sulfated HNK-1 in the kidney is unexpectedly unaltered in mutant mice …

Issue 377: September 2-16, 2021, The Local Voice

The Local Voice

No abstract provided.

College Student Sleep Quality And Mental And Physical Health Are Associated With Food Insecurity In A Multi-Campus Study, Rebecca L. Hagedorn, Melissa D. Olfert, Lillian Macnell, Bailey Houghtaling, Lanae B. Hood, Mateja R. Savoie Roskos, Jeannine R. Goetz, Valerie Kern-Lyons, Linda L. Knol, Georgianna R. Mann, Monica K. Esquivel, Adam Hege, Jennifer Walsh, Keith Pearson, Maureen Berner, Jessica Soldavini, Elizabeth T. Anderson-Steeves, Marsha Spence, Christopher Paul

Faculty and Student Publications

Objective: To assess the relationship between food insecurity, sleep quality, and days with mental and physical health issues among college students. Design: An online survey was administered. Food insecurity was assessed using the ten-item Adult Food Security Survey Module. Sleep was measured using the nineteen-item Pittsburgh Sleep Quality Index (PSQI). Mental health and physical health were measured using three items from the Healthy Days Core Module. Multivariate logistic regression was conducted to assess the relationship between food insecurity, sleep quality, and days with poor mental and physical health. Setting: Twenty-two higher education institutions. Participants: College students (n 17 686) enrolled …

Helping Farms Be In Harmony With Nature, Shea Stewart

University of Mississippi News

EPA grant involves researchers, Mississippi Delta farmers exploring agricultural runoff water

Meet Christina Lewis, August's Staff Member Of The Month, Inside Ole Miss

University of Mississippi News

No abstract provided.

World Of Wonders: In Praise Of Fireflies, Whale Sharks, And Other Astonishments, Aimee Nezhukumatathil

Common Reading Experience

The 2021 UM Common Read is World of Wonders: In Praise of Fireflies, Whale Sharks, and Other Astonishments by Aimee Nezhukumatathil, UM Professor of English and Creative Writing.

As a child, Nezhukumatathil called many places home: the grounds of a Kansas mental institution, where her Filipina mother was a doctor; the open skies and tall mountains of Arizona, where she hiked with her Indian father; and the chillier climes of western New York and Ohio. But no matter where she was transplanted―no matter how awkward the fit or forbidding the landscape―she was able to turn to our world’s fierce and …

Adapting Decarbonylation Chemistry For The Development Of Prodrugs Capable Ofin Vivodelivery Of Carbon Monoxide Utilizing Sweeteners As Carrier Molecules, Ladie Kimberly De La Cruz, Xiaoxiao Yang, Anna Menshikh, Maya Brewer

Faculty and Student Publications

Carbon monoxide as an endogenous signaling molecule exhibits pharmacological efficacy in various animal models of organ injury. To address the difficulty in using CO gas as a therapeutic agent for widespread applications, we are interested in developing CO prodrugs through bioreversible caging of CO in an organic compound. Specifically, we have explored the decarboxylation-decarbonylation chemistry of 1,2-dicarbonyl compounds. Examination and optimization of factors favorable for maximal CO release under physiological conditions led to organic CO prodrugs using non-calorific sweeteners as leaving groups attached to the 1,2-dicarbonyl core. Attaching a leaving group with appropriate properties promotes the desired hydrolysis-decarboxylation-decarbonylation sequence of …

Issue 376: August 19-September 2, 2021, The Local Voice

The Local Voice

No abstract provided.

Heteroacene-Based Amphiphile As A Molecular Scaffold For Bioimaging Probes, Tharindu A. Ranathunge, Mahesh Loku Yaddehige, Jordan H. Varma, Cameron Smith, Jay Nguyen, Iyanuoluwani Owolabi, Wojciech Kolodziejczyk, Nathan I. Hammer, Glake Hill, Alex Flynt, Davita L. Watkins

Faculty and Student Publications

The challenges faced with current fluorescence imaging agents have motivated us to study two nanostructures based on a hydrophobic dye, 6H-pyrrolo[3,2-b:4,5-b’]bis [1,4]benzothiazine (TRPZ). TRPZ is a heteroacene with a rigid, pi-conjugated structure, multiple reactive sites, and unique spectroscopic properties. Here we coupled TRPZ to a tert-butyl carbamate (BOC) protected 2,2-bis(hydroxymethyl)propanoic acid (bisMPA) dendron via azide-alkyne Huisgen cycloaddition. Deprotection of the protected amine groups on the dendron afforded a cationic terminated amphiphile, TRPZ-bisMPA. TRPZ-bisMPA was nanoprecipitated into water to obtain nanoparticles (NPs) with a hydrodynamic radius that was comparison, TRPZ-PG was encapsulated in pluronic-F127 (Mw = 12 kD), a polymer surfactant …

Opening Tiny Worlds Of Exploration, Shea Stewart

University of Mississippi News

NSF funding provides new imaging microscope for UM research

Clinic Helps Children With Language Disorders Prepare For Kindergarten, Staff Report

University of Mississippi News

Preschool Language Group offers help for families in need

The Degree Of Polymerization And Sulfation Patterns In Heparan Sulfate Are Critical Determinants Of Cytomegalovirus Entry Into Host Cells, Dipanwita Mitra, Mohammad H. Hasan, John T. Bates, Michael A. Bierdeman

Faculty and Student Publications

Several enveloped viruses, including herpesviruses attach to host cells by initially interacting with cell surface heparan sulfate (HS) proteoglycans followed by specific coreceptor engagement which culminates in virus-host membrane fusion and virus entry. Interfering with HS-herpesvirus interactions has long been known to result in significant reduction in virus infectivity indicating that HS play important roles in initiating virus entry. In this study, we provide a series of evidence to prove that specific sulfations as well as the degree of polymerization (dp) of HS govern human cytomegalovirus (CMV) binding and infection. First, purified CMV extracellular virions preferentially bind to sulfated longer …

(E)-2,6,10-Trimethyldodec-8-En-2-Ol: An Undescribed Sesquiterpenoid From Copaiba Oil, Mohammed F. Hawwal, Zulfiqar Ali, Mei Wang, Jianping Zhao

Faculty and Student Publications

The use of copaiba oil has been reported since the 16th century in Amazon traditional medicine, especially as an anti-inflammatory ingredient and for wound healing. The use of copaiba oil continues today, and it is sold in various parts of the world, including the United States. Copaiba oil contains mainly sesquiterpenes, bioactive compounds that are popular for their positive effect on human health. As part of our ongoing research endeavors to identify the chemical constituents of broadly consumed herbal supplements or their adulterants, copaiba oil was investigated. In this regard, copaiba oil was subjected to repeated silica gel column chromatography …

Red Algal Sulfated Galactan Binds And Protects Neural Cells From Hiv-1 Gp120 And Tat, Vitor H. Pomin, Fakhri Mahdi, Weihua Jin, Fuming Zhang

Faculty and Student Publications

The potential neuroprotective capacity of four different sulfated glycans: Botryocladia occidentalis-derived sulfated galactan (BoSG) (MW > 100 kDa), Lytechinus variegatus-derived sulfated fucan (LvSF) (MW~90 kDa), high-molecular weight dextran sulfate (DxS) (MW 100 kDa), and unfractionated heparin (UFH) (MW~15 kDa), was assessed in response to the HIV-1 proteins, R5-tropic glycoprotein 120 (gp120) and/or trans-activator of transcription (Tat), using primary murine neurons co-cultured with mixed glia. Compared to control-treated cells in which HIV-1 proteins alone or combined were neurotoxic, BoSG was, among the four tested sulfated glycans, the only one capable of showing significant concentration-dependent neuroprotection against Tat and/or gp120, alone or combined. …

Sulfur Isotopes As A Proxy For Human Diet And Mobility From The Preclassic Through Colonial Periods In The Eastern Maya Lowlands, Claire E. Ebert, Asta J. Rand, Kirsten Green-Mink, Julie A. Hoggarth, Carolyn Freiwald, Jaime J. Awe, Willa R. Trask, Jason Yaeger, M. Kathryn Brown, Christophe Helmke, Rafael A. Guerra, Marie Danforth, Douglas J. Kennett

Faculty and Student Publications

Maya archaeologists have long been interested in understanding ancient diets because they provide information about broad-scale economic and societal transformations. Though paleodietary studies have primarily relied on stable carbon (δ13C) and nitrogen (δ15N) isotopic analyses of human bone collagen to document the types of food people consumed, stable sulfur (δ34S) isotope analysis can potentially provide valuable data to identify terrestrial, freshwater, or marine/coastal food sources, as well as determine human mobility and migration patterns. Here we assess applications of δ34S for investigating Maya diet and migration through stable isotope analyses of human bone collagen (δ13C, δ15N, and δ34S) from 114 …

Poster 02, Ashley Nemec-Bakk

Drug Discovery and Development Colloquium

No abstract provided.

Poster 10, Soumiya Pal

Drug Discovery and Development Colloquium

No abstract provided.

Featured Speaker: Tumorselect Technology: Enhancing Safety And Efficacy Of Cytotoxic Chemotherapeutics, James Mcchesney, Phd

Drug Discovery and Development Colloquium

Session Chair: Rasha Elkanayati, Graduate Student, School of Pharmacy, University of Mississippi

Meet Sandra Cox-Mccarty, June's Staff Member Of The Month, Inside Ole Miss

University of Mississippi News

No abstract provided.

July 7, 2021, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Microscopic Traffic Simulation As A Decision Support System For Road Diet And Tactical Urbanism Strategies, Bernice Liu, Amirarsalan Mehrara Molan, Anurag Pande, Jonathan Howard, Serena Alexander, Zhiliang Lou

Faculty and Student Publications

Urban street networks in the United States have been primarily designed for automobile traffic with negligible considerations to non-motorized transportation users. Due to environmental issues and quality of life concerns, communities are reclaiming street spaces for active modes and slowing the speeds in their downtown. Moreover, tactical urbanism, i.e., the use of street space for innovative purposes other than moving automobile traffic, is becoming attractive due to reduced automobile travel demand and the need for outdoor activities in the age of the COVID-19 pandemic. This study provides details of the modeling of an urban downtown network (in the City of …

Assessment Of Evolutionary Relationships For Prioritization Of Myxobacteria For Natural Product Discovery, Andrew Ahearne, Hanan Albataineh, Scot E. Dowd, D. Cole Stevens

Faculty and Student Publications

Discoveries of novel myxobacteria have started to unveil the potentially vast phylogenetic diversity within the family Myxococcaceae and have brought about an updated approach to myxobacterial classification. While traditional approaches focused on morphology, 16S gene sequences, and biochemistry, modern methods including comparative genomics have provided a more thorough assessment of myxobacterial taxonomy. Herein, we utilize long-read genome sequencing for two myxobacteria previously classified as Archangium primigenium and Chondrococcus macrosporus, as well as four environmental myxobacteria newly isolated for this study. Average nucleotide identity and digital DNA–DNA hybridization scores from comparative genomics suggest previously classified as A. primigenium to instead be …

Transcriptomic Changes And The Roles Of Cannabinoid Receptors And Pparγin Developmental Toxicities Following Exposure To Δ9-Tetrahydrocannabinol And Cannabidiol, Zacharias Pandelides, Neelakanteswar Aluru, Cammi Thornton, Haley E. Watts

Faculty and Student Publications

Human consumption of cannabinoid-containing products during early life or pregnancy is rising. However, information about the molecular mechanisms involved in early life stage Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) toxicities is critically lacking. Here, larval zebrafish (Danio rerio) were used to measure THC- and CBD-mediated changes on transcriptome and the roles of cannabinoid receptors (Cnr) 1 and 2 and peroxisome proliferator activator receptor γ(PPARγ) in developmental toxicities. Transcriptomic profiling of 96-h postfertilization (hpf) cnr+/+ embryos exposed (6 - 96 hpf) to 4 μM THC or 0.5 μM CBD showed differential expression of 904 and 1095 genes for THC and CBD, respectively, …

Episodic Memory Encoding And Retrieval In Face-Name Paired Paradigm: An Fnirs Study, Qian Yu, Boris Cheval, Benjamin Becker, Fabian Herold, Chetwyn C. H. Chan, Yvonne N. Delevoye-Turrell, Ségolène M. R. Guérin, Paul Loprinzi, Notger Mueller, Liye Zou

Faculty and Student Publications

Background: Episodic memory (EM) is particularly sensitive to pathological conditions and aging. In a neurocognitive context, the paired-associate learning (PAL) paradigm, which requires participants to learn and recall associations between stimuli, has been used to measure EM. The present study aimed to explore whether functional near-infrared spectroscopy (fNIRS) can be employed to determine cortical activity underlying encoding and retrieval. Moreover, we examined whether and how different aspects of task (i.e., novelty, difficulty) affects those cortical activities. Methods: Twenty-two male college students (age: M = 20.55, SD = 1.62) underwent a face-name PAL paradigm under 40-channel fNIRS covering fronto-parietal and middle …

Covid-19 Exposure And Diagnosis Among College Student Drinkers: Links To Alcohol Use Behavior, Motives, And Context, Hannah K. Allen, Samantha Cohen-Winans, Kaitlyn Armstrong, Nash C. Clark, M. Allison Ford

Faculty and Student Publications

The COVID-19 pandemic is a public health crisis. College student alcohol use is highly prevalent and primarily occurs in social settings where risk for COVID-19 transmission is heightened. This study explored the associations between alcohol use frequency, quantity, motives, and context with: (i) quarantine due to COVID-19 exposure and (ii) a positive diagnosis for COVID-19. A sample of n = 409 college student drinkers completed an online survey about their health and behaviors during the Fall 2020 semester. Since the start of the semester, 36% of students quarantined and 13% of students received a COVID-19 diagnosis. More frequent alcohol use …

The Remains Of The Fray: Nascent Colonialism And Heterogeneous Hybridity, Charles R. Cobb, James B. Legg, Steven D. Smith, Chester B. Depratter, Brad R. Lieb, Edmond A. Boudreaux

Faculty and Student Publications

Investigations at the Native American site complex of Stark Farms in Mississippi, USA, have yielded numerous examples of metal artifacts of European origin. Our study suggests that they derive from contact between the AD 1540-1541 winter encampment of the Spanish Hernando de Soto expedition and the local Indigenous polity. The artifacts display a wide range of modifications, uses, and depositional contexts congruent with hybrid practices. We argue that the early colonial setting of Stark Farms requires a different perspective on cultural mixing than is often applied in studies of European colonialism. This is highlighted by the strongly improvisational nature of …

(2021) Alexandria Morgan, Alexandria Morgan, Davita Watkins

Ronald E. McNair Post-Baccalaureate Achievement Program

No abstract provided.

(2021) Khamariah Yelder Anderson, Khamariah Yelder Anderson, Kristine L. Willett

Ronald E. McNair Post-Baccalaureate Achievement Program

No abstract provided.