Digital Commons Network^™

Blues Is My Business (And Business Is Good?), David N. Larson

Electronic Theses and Dissertations

This work focuses on the social, political, and economic trends that govern the blues music scene in Clarksdale, Mississippi. Clarksdale is seen as a sort of “ground zero” in the blues world, it is often referred to as, “the land where blues began.” This claim is not without merit but it is not strictly historically accurate. Many of the town’s spokespeople use euphemisms that distort the troubled history of race relations in the town and its music spaces.

This investigation centers around the economic state of the town’s tourism industry, the individuals who act as the town’s promoters, and the …

Role Of Astrocytic Insulin-Like Growth Factor 1 In The Regulation Of Behavior, Cognition, And Neuroinflammation, Brayden Thomas

Electronic Theses and Dissertations

Modern medicine has consistently extended life expectancy over recent decades and centuries. Despite this, age-associated cognitive decline and risk of neurodegenerative disease grow in parallel with lifespan, meaning the capacity to live healthier has not mirrored that to live longer. Many studies in both human and rodents have shown the association between age-related cognitive impairment and reduction of insulin-like growth factor-1 (IGF-1) signaling. Additional research has indicated that dysregulated IGF-1 signaling, either systemic or local to the central nervous system (CNS) in cells like neurons and glia, leads to impaired spatial learning and memory in mice. Glia, or glial cells, …

Enhancing The Oral Drug Delivery Through Hot Melt Extrusion Techniques, Neeraja Komanduri

Electronic Theses and Dissertations

Hot melt extrusion has been developed as a fresh technique for taste masking, in recent years. This method provides many aids as compared to traditional methods like avoiding the use of solvents, continuous manufacturing, ease to scale up, and adaptability to meet the goals of FDA for quality products. This method is useful for various applications like solubility enhancement, abuse deterrence, taste masking, transdermal dosage forms like films, immediate release oral dosage forms. In this work, This technique is explored for its applications using a novel polymer, Kollicoat® Smartseal 100P and its ability to be coupled with FDM 3D printing …

Development Of Local Depot Formulation For Sustained Systemic Delivery Of Proteins, Pranav Ponkshe

Electronic Theses and Dissertations

Protein therapeutics due to their high potency, high specificity, and desirable profile have gained a lot of traction in the last decade. Though the route of administration is limited to parenteral routes. There are also short half-life and instability issues observed in protein therapeutics making it necessary to develop delivery systems.

In the first chapter interleukin 15 as a cytokine was introduced while the second chapter talks more in detail about the development of a local depot hydrogel formulation for the delivery of recombinant interleukin 15. In vitro stability, and release studies were performed to select the optimum formulation for …

Interval Delivery Of 5ht2a Agonists Using Multilayered Polymeric Films, Mehjabeen Hossain

Electronic Theses and Dissertations

There is an urgent unmet medical need to develop therapeutic options for the ~50% of depression patients suffering from treatment-resistant depression, which is difficult to treat with existing psycho- and pharmaco-therapeutic options. Classical psychedelics, such as the 5HT2A agonists, have re-emerged as a treatment paradigm for depression. Recent clinical trials highlight the potential effectiveness of 5HT2A agonists to improve mood and psychotherapeutic growth in treatment-resistant depression patients, even in those who have failed a median of four previous medications in their lifetime. Moreover, microdosing could be a promising way to achieve long-term alleviation of depression symptoms without a hallucinogenic experience. …

Lovie, Annie Vitalsey

Yalobusha Review

No abstract provided.

Ionic Liquid-Solvated Chitosan Nanoparticles As A Novel Method Of Treating Atopic Dermatitis, Leslie Bell

Honors Theses

Atopic dermatitis, or eczema, is an inflammatory skin disease resulting in dry, red, and itchy skin that affects almost 20% of the population of the Western world. This disease creates a physical, emotional, as well as financial burden on those affected, as well as their families. Current treatment options are only somewhat effective, and do not have a long duration of release and therefore efficiency. Furthermore, treatment plans involving corticosteroids need to be closely regulated to monitor side effects such as skin thinning. Other options include topical tacrolimus, emollients, and oral antihistamines, each with varied side effects. This project is …

Characterization And In Vitro And In Vivo Evaluation Of Tacrolimus-Loaded Poly(Ε-Caprolactone) Nanocapsules For The Management Of Atopic Dermatitis, Guilherme Dos Anjos Camargo, Leandro Ferreira, Diego José Schebelski, Amanda Martinez Lyra

Faculty and Student Publications

Background: Tacrolimus (TAC) is a drug of natural origin used in conventional topical dosage forms to control atopic dermatitis. However, direct application of the drug often causes adverse side effects in some patients. Hence, drug nanoencapsulation could be used as an improved novel therapy to mitigate the adverse effects and enhance bioavailability of the drug. Methods: Physicochemical properties, in vitro drug release experiments, and in vivo anti-inflammatory activity studies were performed. Results: TAC-loaded nanocapsules were successfully prepared by the interfacial deposition of preformed polymer using poly(ε-caprolactone) (PCL). The nanoparticu-late systems presented a spherical shape with a smooth and regular surface, …

Issue 383: November 11-December 2, 2021, The Local Voice

The Local Voice

No abstract provided.

From Crafting Cardboard To Creating A Company, Shea Stewart

University of Mississippi News

CME student, Ole Miss business major starts company creating 'man cave must-have'

Patch Size Drives Colonization By Aquatic Insects, With Minor Priority Effects Of A Cohabitant, Reed C. Scott, Matthew R. Pintar, William J. Resetarits

Faculty and Student Publications

Patch size is one of the most important factors affecting the distribution and abundance of species, and recent research has shown that patch size is an important niche dimension affecting community structure in aquatic insects. Building on this result, we examined the impact of patch size in conjunction with presence of larval anurans on colonization by aquatic insects. Hyla chrysoscelis (Cope's gray treefrog) larvae are abundant and early colonists in fishless lentic habitats, and these larvae can fill multiple ecological roles. By establishing larvae in mesocosms prior to colonization, we were able to assess whether H. chrysoscelis larvae have priority …

Exploiting The Final Frontier – Some Initial Thoughts On Regulating Humanity’S Relationships With Non-Terrestrial Life Forms, Rob Amos

Journal of Space Law

No abstract provided.

Insulin-Like Growth Factor-1 Differentially Modulates Glutamate-Induced Toxicity And Stress In Cells Of The Neurogliovascular Unit, Cellas A. Hayes, Brandon G. Ashmore, Akshaya Vijayasankar, Jessica P. Marshall

Faculty and Student Publications

The age-related reduction in circulating levels of insulin-like growth factor-1 (IGF-1) is associated with increased risk of stroke and neurodegenerative diseases in advanced age. Numerous reports highlight behavioral and physiological deficits in blood-brain barrier function and neurovascular communication when IGF-1 levels are low. Administration of exogenous IGF-1 reduces the extent of tissue damage and sensorimotor deficits in animal models of ischemic stroke, highlighting the critical role of IGF-1 as a regulator of neurovascular health. The beneficial effects of IGF-1 in the nervous system are often attributed to direct actions on neurons; however, glial cells and the cerebrovasculature are also modulated …

Meet Kristina Phillips, November's Staff Member Of The Month, Michael Newsom

University of Mississippi News

No abstract provided.

Plant Extract Of Limonium Gmelinii Attenuates Oxidative Responses In Neurons, Astrocytes, And Cerebral Endothelial Cells In Vitro And Improves Motor Functions Of Rats After Middle Cerebral Artery Occlusion, Tulendy Nurkenov, Andrey Tsoy, Farkhad Olzhayev, Elvira Abzhanova

Faculty and Student Publications

There are numerous publications demonstrating that plant polyphenols can reduce oxi-dative stress and inflammatory processes in the brain. In the present study we have investigated the neuroprotective effect of plant extract isolated from the roots of L. gmelinii since it contains a rich source of polyphenols and other biologically active compounds. We have applied an oxidative and inflammatory model induced by NMDA, H2O2, and TNF‐α in human primary neurons and astrocytes, and mouse cerebral endothelial cell (CECs) line in vitro. The levels of ROS generation, NADPH oxidase activation, P‐selectin expression, and activity of ERK1/2 were evaluated by quan-titative immunofluorescence analysis, …

Filmmaker Visits Oxford To Close Out Sarahfest, Staff Report

University of Mississippi News

Kate Tsang to explore movie's coming-of-age themes in craft talk

Meet Lynne Trusty, October's Staff Member Of The Month, Inside Ole Miss

University of Mississippi News

No abstract provided.

Development Of L-Γ-Methyleneglutamine-Based Compounds For Cancer, Md. Imran Hossein, Fakhri Mahdi, Md. Imdadul H. Khan, Nicholas S. Akins, Patrice Penfornis, Seong Jong Kim, Barbara S. Slusher, Jason J. Paris, Hoang V. Le, Pier Paolo Claudio

Annual Poster Session 2021

Presenter: Md. Imdadul H. Khan

Discovery Of 5Α-Pregnan-2Β,3Α-Diol-20-One As A Neurohiv Protective Agent, Md Imdadul H. Khan, Mohammed F. Salahuddin, Nicholas S. Akins, Fakhri Mahdi, Seong Jong Kim, Jing Li, Jason J. Paris, Hoang V. Le

Annual Poster Session 2021

Presenter: Md Imdadul Khan

Environmental Enrichment Provided To Adult Zebra Finches (Taeniopygia Guttata) Differentially Influences Sexes On A Spatial Learning Task, Arma'rosa Wilks-Mohead, Laura West, Lainy B. Day

Annual Poster Session 2021

Presenter: Arma'Rosa Wilks-Mohead

Age-Related Neuroendocrine, Cognitive, And Behavioral Co-Morbidities Are Promoted By Hiv-1 Tat Expression In Male Mice, Alaa Qraeya, Fakhri Mahdi, Marc Kaufman, Nicole M. Ashpole, Jason J. Paris

Annual Poster Session 2021

Presenter: Alaa Qraeya

Issue 380: October 14-28, 2021, The Local Voice

The Local Voice

No abstract provided.

Consider The Amphibian, Shea Stewart

University of Mississippi News

UM biologist part of institute studying species' resiliency against disease

Preparation And In Vitro/In Vivo Evaluation Of Orally Disintegrating/Modified-Release Praziquantel Tablets, Xuemei Wen, Zhaoyou Deng, Yangfeng Xu, Guoqing Yan

Faculty and Student Publications

This study was designed to develop orally disintegrating/sustained-release praziquantel (PZQ) tablets using the hot-melt extrusion (HME) technique and direct compression, and subse-quently evaluate their release in in vitro and in vivo pharmacokinetics. For the extrusion process, hypromellose acetate succinate (HPMCAS)-LG was the carrier of pure PZQ, with a standard screw configuration used at an extrusion temperature of 140◦ C and a screw rotation speed of 100 rpm. Differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), powder X-ray diffraction (PXRD) and Fourier-transform infrared spectroscopy (FTIR) were performed to characterize the extru-date. Orally disintegrating/sustained-release praziquantel tablets (PZQ ODSRTs) were prepared by direct compression …

Pharmacy Matters - October 2021, University Of Mississippi. School Of Pharmacy

Pharmacy Matters Newsletters

Featured stories: "Pharmacy Graduate Students Win AAPS Student Chapter Award," "Stellar Student: Hyllore Imeri," "Pharmacology Graduate Student Striving for Excellence"

Pharmacology Graduate Student Striving For Excellence, Patrick Smith

University of Mississippi News

Salahuddin Mohammed seeks to inspire future students through his work

Issue 379: September 30-October 14, 2021, The Local Voice

The Local Voice

No abstract provided.

Meet Lele Gillespie, September's Staff Member Of The Month, Inside Ole Miss

University of Mississippi News

No abstract provided.

Finding The Inner Teacher In Holly Springs, Michael Newsom

University of Mississippi News

Mississippi Teacher Corps marks 15 years of teacher training and summer programs in school system

September 16, 2021, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.