Digital Commons Network^™

Preparation, Characterization And In-Vitro Release Studies Of Icg-Encapsulated Liposomes, Prateek Uttreja

Electronic Theses and Dissertations

The purpose of the present study was to create Indocyanine Green (ICG) loaded liposomal formulations that were efficient and had controlled drug release. During the Second World War, the photographic dye indocyanine green (ICG) was created. ICG was developed as a medical diagnostic tool for cardiac output tests and for monitoring liver function after receiving FDA approval. The preparation of ICG-encapsulated conventional and PEGylated liposomes containing different types of phosphatidylcholine (PC) such as HSPC, DSPC, DPPC and cholesterol (CH) in the molar ratios of 55:45 and PC:CH: DSPE-PEG2K (polyethylene glycol) in the molar ratio of 55:40:5 respectively was done using …

Inclusive Music Teacher Preparation In The Presbyterian College Of Education At Akropong-Akuapem, Ghana, Samuel Agbenyo

Electronic Theses and Dissertations

For the past three decades, Inclusive Education (IE) has emerged as a crucial educational agenda all over the world. In this study, IE is the practice of including students with disabilities in the general (music) education classroom, where they are educated together with their typically developing peers. Although IE efforts began in Ghana in 1957, some pitfalls have characterized the implementation process over the years, especially regarding music teacher preparation to implement the policies. Studies have reported a state of frustration among stakeholders, notably the elementary school teachers, who feel inadequately prepared to teach within IE settings. In this case …

On Statistical Models For Signal Detection, Adedotun Michael Lawal

Electronic Theses and Dissertations

A thesis on developing statistical models that will aid in predicting signal detection at an infrasound sensor given a noise model for the sensor. The thesis aims first to provide a means to sample from a set of atmospheric profiles effectively using a statistical model, so we can have a smaller sample space to generate transmission loss values, saving time for running propagation models. And secondly, it aims to provide a formalism for a signal detection criterion using signal-to-noise ratio. The statistical model is developed using Empirical Orthogonal Function Analysis also known as Principal Component Analysis, and Inverse Transform Sampling. …

Hiv-1 Tat And Opioids: Implications For Stress-Related Psychopathology, Salahuddin Mohammed

Electronic Theses and Dissertations

The overarching goal of this dissertation was to assess the interaction of HIV-1 Tat protein with opioids like oxycodone and the hypothalamic-pituitary-adrenal (HPA) axis and develop novel therapeutic strategy to restore HPA dysfunction in adult HIV-1 Tat transgenic mice. In the past 3 decades, combined antiretroviral therapeutics (cART) has increased the life expectancy of HIV infected individuals, with a significant decline in the number of deaths. However, due the inability of cART to sufficiently target latent CNS viral reservoirs (predominantly microglia and astrocytes to a lesser extent), approximately 50% of the HIV+ infected population contends with neurological, neuropsychiatric and neuroendocrine …

Synthesis And Charecterisation Of Methylene Blue Derivatives, Rohit Alluri

Electronic Theses and Dissertations

Since its discovery, the fluorescent dye known as methylene blue has been employed in a variety of scientific disciplines. Methylene blue (MB) for intraoperative fluorescence imaging has only lately been employed. 10-N-carbamoyl linkage modification of Methylene blue helps us in developing compounds with off-to-on fluorescence switch in the presence of near infrared (NIR). Due to its naturally induced photodamage to normal tissues and deeper penetration of lesion regions when compared to UV and visible light, near infrared (NIR) light is considered favorable among the broad radiation range. The previously synthesized derivatives are not completely soluble in water, they require other …

Cellular Mechanisms Of Igf-1 Neuroprotection After Ischemic Stroke, Cellas A. Hayes

Electronic Theses and Dissertations

Strokes are a leading cause of mortality and disability worldwide; thus, there is a dire need for new, effective pharmacotherapeutics that can be administered to reduce the burden of disease post-insult. Clinical findings have shown that insulin-like growth factor-1 (IGF-1) levels and post-stroke functional outcomes exhibit a positive relationship. Importantly, the administration of exogenous IGF-1 in rodent models of ischemic stroke attenuates neurological damage and functional deficits following stroke. Ongoing stroke damage after the initial insult is primarily induced by increased extracellular glutamate causing substantial neuronal death, increased neuro-inflammation, and leading to greater tissue loss. Evidence from our laboratory has …

Physiological Corticosterone Attenautes Gp120-Mediated Microglial Activation And Is Associated With Reduced Anxiety-Like Behavior In Gp120-Expressing Mice, Emaya Marie Moss

Electronic Theses and Dissertations

Human immunodeficiency virus (HIV) persists as a global pandemic. Despite the benefits of combinatorial antiretroviral therapies (cART), virotoxic HIV proteins are still detectable within the central nervous system and approximately half of all cART-treated patients contend with neurological impairments. The mechanisms underlying these effects are not known, but likely involve actions of virotoxic HIV proteins including glycoprotein 120 (gp120). Glycoprotein 120 is neurotoxic, in part due to its capacity to activate microglia. Corticosterone, an endogenous anti-inflammatory, has been found to attenuate neuronal death caused by gp120-induced microglial cytokine production in vitro. But, the concentration-dependent effects of corticosterone to influence microglial …

Α-Tocopherol Succinate Nano Structured Lipid Carriers For The Ocular Delivery Of The Anticancer Agents And Statistical Modeling Of Release Study Profiles By Linear Mixed Models, Sushrut Marathe

Electronic Theses and Dissertations

Retinoblastoma (RB) is a rare type of cancer that develops quickly from immature retinal cells. Enucleation, external beam radiotherapy, episcleral plaque radiotherapy, and cryotherapy have been the treatment options for the RB.

Paclitaxel (PTX) is an effective antineoplastic medication with a wide range of applications in the treatment of malignant tumors., systemic toxicity, quick elimination, and resistance limit its clinical use. Due to its limited solubility, PTX formulations have proven difficult to develop, necessitating the use of Cremophor® EL and organic solvents. Furthermore, the blood-retinal barrier prevents PTX from penetrating into the ocular tissues. The goal of this work was …

Inevitable Mortality And The Incessant Momentum Of Medicalized Death, Clifford Mckay

Electronic Theses and Dissertations

Atul Gawande, MD, affirms the inevitability of human mortality and the end of life in natural death. He decries current medical delivery’s incessant momentum toward medicalized death and recommends a meaningful conversation between doctor and patient to chart a course of care that supports what is important to the patient. But the tradition of a doctor’s dominance and a patient’s submissiveness disrupts the conversation. New definitions of both doctor and patient, and the intent to respect a patient’s autonomy, will facilitate decision-making and support patients’ values at the end of life, diminishing the momentum of medicalized death.

Investigating The Effects Of Absurd Humor And Mortality Salience On Moral Identity, Belongingness, Belief In A Just World, And Meaning In Life, Joshua Semko

Electronic Theses and Dissertations

Background: Humans have a sense of meaning, and people actively create and maintain meaning in their lives. One way humans make meaning is through fluid compensation, which is the automatic process of compensating for a threat to one’s global meaning system by temporarily strengthening other, non-related beliefs. This phenomenon has been thoroughly investigated in response to mortality salience (i.e., reminders of one’s death), but not absurd humor. This is important because little is known about the role of humor in meaning making. More research is needed to determine whether humor is a unique meaning-making process. Further, no studies have investigated …

Bridging The Gap Between Journalism 273 And Graduation, And Beyond, Mackenzie Slate Ross

Electronic Theses and Dissertations

While Journalism 273: Creative Visual Thinking is a requirement for all undergraduate students majoring in Integrated Marketing Communications and some students majoring in Journalism, there are students who end up graduating from the University of Mississippi with a desire for more knowledge of graphic design. Feedback from current students in the School of Journalism and New Media at the University of Mississippi as well as alumni of the program was gathered in two surveys to understand better how Journalism 273 benefits them and pinpoints opportunities for improvement. One hundred nineteen students who took Journalism 273 and were enrolled in the …

The Queer And Trans Ecologies Of Shakespeare's Ocean, Elijah Two Bears

Electronic Theses and Dissertations

This thesis squarely approaches the overlooked theoretical nexus of early modern blue ecologies and LGBTQIA2S+ studies to argue that Shakespeare's ocean is a deeply queer space that inspires both queer and trans effects in his characters, plays, and audiences across time. I argue you can’t fully process Shakespeare’s aquatic environments, and the broader range of his more watery plays, without accounting for the queer destabilization and trans self-fashioning that is inextricably linked with encountering the ocean, whether it is through shipwreck, ship travel, or near-drownings. This project recreates a lost world using whatever small gems of textual and historical evidence …

Application Of Hot-Melt Extrusion And Fused Deposition Modeling On Screening Filaments And Developing Diverse Dosages, Pengchong Xu

Electronic Theses and Dissertations

Three-dimensional printing (3DP) provides a flexible and cost-beneficial solution to patient-centric medicine and its potential to challenge current pharmaceutical supply chains. Fusion deposition modeling (FDM) is one of the most commonly applied 3D printing techniques in pharmaceutical study. But the poor mechanical properties of printing filaments have limited mainly the application of FDM 3D printing in the pharmaceutical area. In this dissertation, the development of texture analysis methods to evaluate the printability of filaments was investigated first. The parameter “Stiffness” was successfully developed to measure and predict the printability of filaments in the direct-extrude FDM printer. Then, the combination of …

Domestic Lives Of The Worthless And Insignificant: Land And Labor In Eighteenth-Century British Literature, Mellissa Black

Electronic Theses and Dissertations

Domestic Lives posits that the proliferation of the georgic mode in selected eighteenth-century works provided writers with the language and tropes needed to negotiate burgeoning stresses on the stability of political, cultural, and class systems. In my reading of the georgic as a “gentrifying” force, the mode generates and recreates a managerial authority over the productive potential of what I call the “laboring sort,” those who are rooted in agricultural labor. In turn, the georgic aided the expansion of the British empire by allowing for the expansion of definitions of national identity. As national identity was gentrified, so too was …

Perceived Value Of A Vr (Virtual Reality) Tourism Experience: A Scale Development, Fernando Arroyo Lopez

Electronic Theses and Dissertations

Firms are skeptical about what values travelers anticipate obtaining from a Virtual Reality (VR) experience in tourism, and the valuation of trade-offs they are willing to make. This scale development aimed to fill this gap in the literature by creating a scale that can capture the perceived value derived from a VR experience in tourism. This research study adhered to well-established, mainstream psychometric scale creation and validation methods as demonstrated by several authors. This study provides a key step in developing measurement theory related to the perceived value derived from a VR experience in tourism and identifies four value dimensions: …

Karaites & Reformers: Two Failed Cases Of Coherent Interpretation, Menashe Chaim Roberts

Electronic Theses and Dissertations

There are two groups which claim that proper textual interpretation does not require extratextual information. They posit that the meaning of texts is discoverable from the words of the text and/or an individual's reason alone. Thus, no extratextual information is required to arrive at a cogent and coherent interpretation. The medieval Karaites reject the notion that there is any such thing as interpretive precedent and everyone's interpretation, when guided by reason, is as valid and coherent as anyone else's. Early Protestant Reformers such as John Calvin and Martin Luther argue that all one needs to interpret the Bible is the …

Sustained Delivery Of Carbon Monoxide (Co) Via Organic Co Prodrugs: Pharmacokinetic Studies, Minjia Wang

Electronic Theses and Dissertations

Carbon monoxide (CO) is widely known as poisonous gas. Its role as a signaling molecule (gasotransmitter) with various therapeutic effects is less known. Recent years have seen a surge of interest in CO because of its demonstrated therapeutic effect in treating conditions such as inflammation, drug-induced toxicity, ischemia-reperfusion injury, and kidney injury, among others. In developing CO-based therapeutic agents, one key issue is the availability of pharmaceutically acceptable ways of delivering CO. During the past decade, there has been a large number of experiments in cell culture, animal models, and clinical trials using CO gas incubation/inhalation and heavy metal based …

A History Of Freed Slaves' Homes In Northern Nigeria, 1900-1926, Ajibola A. Abdulrahman

Electronic Theses and Dissertations

This dissertation is about the children rescued from slave traders by the British colonial government in Northern Nigeria in the early twentieth century. The children were first settled in state-owned Freed Slaves Homes located at Zungeru and Borno provinces in 1904. After the state-owned Homes were abolished in 1909, they were moved to the privately-owned Lucy Memorial Freed Slaves’ Home. The study focuses on the experiences of these liberated children within the premises of the Freed Slaves' Homes and in settings outside of these institutions in Northern Nigeria. Drawing on previously unused archival materials obtained from various parts of the …

The Perception And Strategies Of Speech-Language Pathologists In Rapport Building With People With Aphasia Via Tele-Practice: Qualitative And Quantitative Mixed Design, Emily Hershberger

Electronic Theses and Dissertations

Introduction: Tele-practice has become an important service delivery method, especially since the Covid-19 pandemic. A majority of research investigated effectiveness in therapeutic outcomes among children and adolescents, while tele-practice studies among people with aphasia were relatively limited. Rapport building may present more challenges in tele-practice compared to in-person services, yet no study compared it across the two therapy delivery approaches among people with aphasia.

Method: This current study conducted interviews regarding how rapport building is affected in tele-practice from speech-language pathologists (SLPs) who have experienced both in-person and tele-practice among people with aphasia. Nine SLPs were interviewed about their perceptions …

The Resilience Of Black Love, Janeth Jackson

Electronic Theses and Dissertations

For countless years, a network of laws, codes, systemic structures, and malicious forces have been established to eradicate Black love. Despite such evils, African Americans have been steadfast in their love for one another. In the American South, the evidence of that steadfastness is the strongest. States like Mississippi, Georgia, and Louisiana all had racist systems such as slavery, Jim Crow, Black Codes, and lynching that African Americans faced daily. And within each structure, there were methods employed to separate Black couples. Some historical texts have examined the plight of African American couples’ fight against such systems. However, few studies …

Finding Aid For The Jamie L. Whitten Collection (Mum00732)

Archives & Special Collections: Finding Aids (alphabetical)

Jamie L. Whitten represented his Mississippi district in the U.S. House of Representatives from 1941 to 1995 and chaired the powerful Committee on Appropriations from 1979 through 1992.

Unearthing The Old South/West: Histories Of Racial Capitalism In Modernist Border Narratives, Bailey Moorhead

Electronic Theses and Dissertations

“Unearthing the Old South/West” examines four works of modernist historical fiction which accentuate competing regimes of racial capitalism through South/Western border settings. Following the trend in New Southern and Western Studies to break with exceptionalist and essentialist considerations of these regions, my analysis challenges white-centric narratives of the U.S. South and West and questions their popular portrayals as culturally distinct spaces. Viewing the U.S. as a site of ongoing settler colonialism, imperialist conquest, and international trade reliant upon labor exploitation, I develop the idea that South/Western borders form a microcosm for larger structures of systemic oppression throughout the nation by …

Expressions Of Femininity, Black Feminism, And Pan-Africanist Rhetoric In Black Popular Music, Alonya Lei Castillo

Electronic Theses and Dissertations

Black women have long been subjected to misrepresentations and stereotypes which have denied them full access to their own femininity and womanhood. These misrepresentations and stereotypes are pervasive in Euro-American culture and can be clearly observed in film, television, and music. As a result, these women have combatted such narratives as an expression of agency. One of the most notable ways Black women have accomplished these goals is through Rap and R&B, genres that have allowed them to shape and reshape notions of femininity and Black womanhood. The participation of Black women in these musical traditions frequently draw on womanist …

Research News, Publications, 2022, Volume 2, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period of April 1 through June 30, 2022.

Research News, Publications, 2022, Volume 1, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period of January 1 through March 31, 2022.

Botanical Aphrodisiacs For Women's Health, Hayley N. Prescott

Electronic Theses and Dissertations

Female Sexual Dysfunction (FSD) affects nearly 40% of women in the United States. While males have five FDA approved drugs for ED, there is only one FDA-approved as-needed treatment for premenopausal women with acquired, generalized Hypoactive Sexual Desire Disorder (HSDD), the most prevalent FSD. The lack of approved drugs is largely due to the biopsychosocial complexity of HSDD; however, there are neurobiological underpinnings evident. Due to the lack of safe efficacious treatment options, we hypothesize that botanical species traditionally used as aphrodisiacs may be promising leads, and exert their effects via activation of melanocortin’s, an excitatory circuit implicated in sexual …

This Is Home: Stories Of H-2a Placemaking In The U.S. And Mexico, Lillian Slaughter

Electronic Theses and Dissertations

This thesis contextualizes the lived experiences of two agricultural guest workers who I work with in Kentucky. Beginning in 1917, the history of agricultural guest worker programs in the United States is detailed up until today with the H-2A visa program. The first chapter pro-vides this history and pays close attention to the impact of the liberalization of Mexico’s econo-my and integration into the larger agricultural market between the US and Canada. In chapter two, census data of Kentucky and the county that the farm is located, provides a background on the Latino population. This chapter focuses on the growth …

Implications Of Gender Dysphoria On Gender Schema And Social Cognitive Theories Of Gender Development, Beau Bourgeois

Electronic Theses and Dissertations

This project considers the implications of gender dysphoria under two prominent theories of gender development, gender schema theory (GST) and social cognitive theory (SCT). Gender dysphoria is considered a significant motivator for transgender behavior and is presented in the DSM-5 as the experience of a strong desire, or as primarily affective in nature. GST and SCT differ in a number of ways, most notably in the role affect plays for gender development and behavior motivations. The former places primary emphasis on environmental influences, leaving the role of affect in question, while the latter posits gender behavior and motivation as an …

Late-Stage Diversification Of Select Natural Products €“ New Chemical Entities With Improved Biological Activities, Moneerah J. Alqahtani

Electronic Theses and Dissertations

Owing to their complexity, diverse structures and molecular targets, natural products have contributed, and will continue to contribute, to the development and discovery of new drugs. Although natural products provide numerous active compounds, their complex structures and poor pharmacokinetics make meeting the eligibility criteria for clinical trials unfeasible. In order to improve their drug-likeness, structural modification is an effective tool to generate countless natural product-based molecules with potential therapeutics. This proposal entails synthetic efforts towards late-stage diversification of natural products in two projects.

The first study highlights the multi-factorial nature of Alzheimer’s disease and brings attention to the importance of …

The Epistemic Obligations Of The Ideal Citizen: A Neo-Aristotelian Solution For Truth-Decay In Democratic Societies, Dakota Shane Layton

Electronic Theses and Dissertations

Contemporary democratic societies are currently encumbered by the problem of truth-decay. Truth-decay is defined as the following set of interrelated trends: