Digital Commons Network^™

Language Models For Rare Disease Information Extraction: Empirical Insights And Model Comparisons, Shashank Gupta

Theses and Dissertations--Computer Science

End-to-end relation extraction (E2ERE) is a crucial task in natural language processing (NLP) that involves identifying and classifying semantic relationships between entities in text. This thesis compares three paradigms for end-to-end relation extraction (E2ERE) in biomedicine, focusing on rare diseases with discontinuous and nested entities. We evaluate Named Entity Recognition (NER) to Relation Extraction (RE) pipelines, sequence-to-sequence models, and generative pre-trained transformer (GPT) models using the RareDis information extraction dataset. Our findings indicate that pipeline models are the most effective, followed closely by sequence-to-sequence models. GPT models, despite having eight times as many parameters, perform worse than sequence-to-sequence models and …

The Aesthetics Of Environmental Risk In Paolo Bacigalupi’S The Windup Girl And The Water Knife, David Schwartz

Theses and Dissertations--English

Any work of environmentally oriented fiction that seeks to represent the wide-reaching effects of climate change is faced with the problem of scale. These texts must render visible change which is at once ubiquitous and microscopic, along with the cascade of side-effects generated in the wake of rising temperature, rising sea levels, and winnowing biodiversity. In short order, these texts must fully imagine what it means to live within the modern global risk society. Borrowing this sociological model from the late Ulrich Beck, I analyze the literary work of Paolo Bacigalupi, one of the foremost authors in the growing genre …

Spaces Of Citizenship: Negotiating Belonging Through Cold War Literature And Culture, Daria Goncharova

Theses and Dissertations--English

At the height of Cold War containment culture, when fears of Communism and nuclear warfare overlapped with anxieties about homosexuality, gender inversion, miscegenation, and juvenile delinquency, formal citizenship—narrowly defined as one’s legal status—did not provide all American citizens with a sense of belonging, equal access to civil liberties, and a reasonable degree of safety. Instead, spatialized identity, rather than civic responsibilities and legal rights, came to define the boundaries of proper citizenship. In this context, highly exclusionary suburbs, which sprang up outside major metropolitan areas in the late 1940s-1950s, emerged as a cornerstone of the cultural narratives defining American citizenship. …

Trust And Knowing In Nineteenth-Century American Literature: Fictional Genres And Metacognitive Disruptions, Jessica Marie Van Gilder

Theses and Dissertations--English

This dissertation investigates how constructions of trust can be undermined or reinforced by examining trust’s entanglement with our compulsive and subjective desire to know in nineteenth-century American literature. Specifically, I analyze how different fictional genres – satire, historical romance, fantastic, and gothic – respond to our desire to know through the types of trust fictional texts feature and construct with the reader. In doing so, I demonstrate how genres of fiction in nineteenth-century America function as dynamic social contracts that amplify and undermine the reader’s trust in larger sociopolitical systems (e.g., national identity) and the epistemologies that underpin those systems …

Writing White Women: White (Supremacist) Feminism In American Literature And Culture, Post Suffrage To Post Hillary (1920–2020s), Jannell C. Mcconnell Parsons

Theses and Dissertations--English

Recent critical texts by Jessie Daniels, Mikki Kendall, and more frame the histories of mainstream white feminism in ways that highlight its ongoing complicity with white supremacy and its maintenance of racist structures and systems. In conversation with these current scholarly as well as mainstream cultural conversations about white feminism that have been happening with more frequency since 2016, this project turns to post-suffrage narratives of white womanhood to historicize the modern narratives we tell about feminism’s history. Each chapter of this project considers a 1920s or 1930s literary narrative alongside current literary and cultural narratives as I explore the …

Effects Of Neonatal Estradiol Treatment On Regulating Sexual Differentiation Of Daily Rhythms Underlying Diet-Induced Obesity In Female Mice, Samuel Nwadialo

Theses and Dissertations--Biology

Sex differences of the brain and behavior often require the combination of organizational and activational effects of sex hormones. The activational effects of estrogens in adult female mice protect daily eating and activity rhythms from disruption by high-fat diet feeding and inhibit diet-induced obesity. However, male mice have disrupted eating rhythms when fed high-fat diet and this causes obesity. Treatment of adult male mice with estradiol does not protect rhythms from disruption by high-fat diet, as it does in females. In this study, we sought to determine whether the organizational effects of estradiol masculinize the daily eating and activity rhythms …

Visualizing And Automating Past, Real-Time, And Forecast Dynamic Hazard Maps For Shallow Colluvial Landslides In Eastern Kentucky, Nathaniel O'Leary

Theses and Dissertations--Earth and Environmental Sciences

Landslide hazards are a persistent threat to communities and infrastructure in Eastern Kentucky, where steep slopes, shallow colluvial soils, and variable hydrological conditions make slope failures frequent. This thesis presents an integrated approach to landslide hazard mapping (LHM) through the development of dynamic, spatiotemporal LHMs for shallow colluvial landslides. Two studies within this work investigate and refine the use of the Lu and Godt (2008) factor of safety (FS) equation to improve landslide predictions. The first study establishes a novel LHM workflow using Hydrus-1D to simulate soil moisture infiltration and fluctuations from precipitation and evapotranspiration (ET) data. This study also …

Sh-Wave Seismic-Reflection Efficiency Technique For Investigating The Wolf Island Fault, New Madrid Seismic Zone, Usa, Stephanie Vicroy

Theses and Dissertations--Earth and Environmental Sciences

The Reelfoot Fault within the New Madrid seismic zone has displacement at seismogenic depth to which the surface expression has unequal displacement. Previous work identified northeast-oriented transpressional fault strands northeast of a bend in the scarp as evidence for a through-going shear-zone, acting as potential accommodation for the observed strain imbalance. This investigation projected the trend of these faults to their intersection with an industry seismic survey at Wolf Island, Missouri, which exhibits a similarly structured faulted zone. We suggest this structure is the continuation of the through-going shear zone representing a previously unknown 22-km-long Quaternary-active fault that can affect …

Estrogen Signaling Regulates The Sex Difference In Resynchronization To Abrupt Shifts Of The Light-Dark Cycle In A Mouse Model Of Jet Lag, Maria Venegas

Theses and Dissertations--Biology

The circadian system coordinates 24-hour cycles of internal biological processes with the environmental light-dark cycle. Abrupt shifts in the timing of the light-dark cycle misalign internal circadian clocks with the environment and cause jet lag until resynchronization occurs. The objective of this study was to investigate the mechanisms underlying sex differences in jet lag in mice. Female mice resynchronized faster than male mice to 6-hour advances and delays of the light-dark cycle, which mimicked eastward and westward travel, respectively. Circulating estradiol was necessary for rapid resynchronization in female mice since ovariectomized females resynchronized slower than mice treated with estradiol. We …

Crisis, Genre, And The Informatic Infrastructure Of The Critical Path Aids Project In Philadelphia's Early Epidemic, Sid Feinberg

Theses and Dissertations--Geography

The Critical Path AIDS Project was a grassroots information network that distributed AIDS-related information related to biomedicine, social services, and politics. I explore the ways the project made sense of the shattering social service and care landscapes they emerged within and responded to. I situate Critical Path’s work within Philadelphia’s splintering care infrastructures and the experience of crisis Lauren Berlant argues structures perception of neoliberal life. I focus on the ways that Critical Path’s articulation of crisis and spatial re-orientation pull on the modernist design work of Buckminster Fuller. Fuller’s design work formed a framework through which the project constructed …

A Geography Of Transgender Belonging In Louisville, Kentucky, Lj Mcallister

Theses and Dissertations--Geography

Louisville, Kentucky is home to a surprisingly robust – and complex – transgender community. This study uses qualitative data from interviews, collaborative maps, and archival research to analyze a geography of belonging for transgender residents in the city. It discusses how the twelve participants negotiate their relationships with the conservative, “red” state of Kentucky, as well as the geographical decision-making they use to navigate Louisville’s many neighborhoods. Ultimately, this thesis draws attention to the ways in which prejudice shapes the landscape of belonging for transgender life in Derby City.

The Movie Is On!: Pragmatics Of The Video Joker In Who Killed Captain Alex?, Hunter Hulett

Theses and Dissertations--Linguistics

The film Who Killed Captain Alex? (WKCA) is a Ugandan film that provides an opportunity to examine the use of pragmatic and specifically deictic features to study the manipulation of borders between the film and reality. A commentator called the Video Joker (VJ) is the film’s deictic center, constantly destabilizing deictic relations and orienting the internal and external pragmatics of the film around themself. As the film’s ultimate pragmatic force, they occupy a position blurring diegesis and non-diegesis due to originating as real-time film commentators before being edited into the text. In this unique position, they shift the deixis’s organization …

La Nueva Argumentación De Twitter: El Cambio De Paradigma Retórico Y La Independencia De Catalunya En Tuits, David Cortes Ferrandez

Theses and Dissertations--Hispanic Studies

Technology changed our world and shapes our reality in forms that widely differ from the traditional ones. Discourse and persuasion are not an exception. This study analyzes the tweets and oral discourses of eight politicians and social leaders during three of the most important days in the independence struggle between Catalonia and Spain to argue that the way people in power try to persuade their voters is changing, especially in new social networks such as Twitter.

The main object of study are the argumentative and persuasion processes that take place both in Twitter and oral discourses from the same politicians …

Confronting Yanqui Racismo: The Cuban Revolution And The (R)Evolutionary Radicalization Of Amiri Baraka, Ariane Ribeiro Santana

Theses and Dissertations--History

This study examined the July 1960 trip to Cuba financed by the Fair Play for Cuba Committee and the Cuban cultural center Casa de las Américas, in which the Black poet and activist Amiri Baraka took part. Diving into his experiences in Cuba and his later writings, it is possible to conceive of diaspora as an interaction that is based not only on race, but on points of common oppression, as seen between Baraka and the African American delegation he joined in 1960 and the Cuban society he engaged with during the trip. This work therefore furthers the field of …

Dirichlet Problems In Perforated Domains, Robert Righi

Theses and Dissertations--Mathematics

We establish W^1,p estimates for solutions u_ε to the Laplace equation with Dirichlet boundary conditions in a bounded C¹ domain Ω_{ε, η} perforated by small holes in ℝ^d. The bounding constants will depend explicitly on epsilon and eta, where epsilon is the order of the minimal distance between holes, and eta denotes the ratio between the size of the holes and epsilon. The proof relies on a large-scale L^p estimate for ∇u_ε, whose proof is divided into two main parts. First, we show that solutions of an intermediate problem for a …

Uniform Regularity Estimates For The Stokes System In Perforated Domains, Jamison R. Wallace

Theses and Dissertations--Mathematics

We consider the Stokes equations in an unbounded domain $\omega_{\epsilon,\eta}$ perforated by small obstacles, where $\epsilon$ represents the minimal distance between obstacles and $\eta$ is the ratio between the obstacle size and $\epsilon$. We are able to obtain uniform $W^{1,q}$ estimates for solutions to the Stokes equations in such domains with bounding constants depending explicitly on $\epsilon$ and $\eta$.

Modulating The Mtor Pathway Using Inducible Retrogradely Transported Aavs As A Novel Approach To Improve Motor Recovery In Spinal Cord Injury, Christopher Bosse-Joseph

Theses and Dissertations--Medical Sciences

Spinal cord injury poses multiple regeneration barriers, including neuronal-intrinsic and extrinsic factors. Overcoming these barriers has stood as a longstanding challenge in neuroscience. A well-studied mechanism to promote spinal cord regeneration and locomotor recovery is activating the PI3K/mTOR pathway by knocking out phosphatase and tensin homolog protein (PTEN). PTEN knockout (PTEN-KO) studies have traditionally used adeno-associated virus (AAV) viral vectors to improve functional recovery. The use of traditional AAV serotypes to induce PTEN-KO has shown promise to improve functional recovery in rodent models; however, these approaches show significant limitations for translational utility. Firstly, the use of traditional AAV serotypes to …

Caenorhabditis Elegans Rapgef Promotes Synaptic Development Through A Small G Protein Signaling Cascade, Reagan Em Lamb

Theses and Dissertations--Neuroscience

Synaptic dysfunction is a major contributor toward the development of many neurological disorders. For proper development, synapses require a series of signaling pathways to guide them, but not all the mechanisms underlying these processes are understood. Here, we used the neuromuscular junction of Caenorhabditis elegans as a model circuitry for examining underlying pathways that mediate proper development of synapses. We hypothesized that the C. elegans RapGEF2 and RapGEF6 orthologue, PXF-1, contributed toward development of cholinergic synapses at the neuromuscular junction. Using behavioral assays and fluorescence microscopy, we found that pxf-1 mutant animals had decreased neuromuscular junction function and decreased synaptic …

Contributions Of The Replication Initiator Protein Dnaa To Physiology And Virulence Of The Lyme Disease Spirochete, Andrew Krusenstjerna

Theses and Dissertations--Microbiology, Immunology, and Molecular Genetics

Borrelia burgdorferi, the etiological agent of Lyme disease, is the most prevalent vector-borne disease in the United States. The spirochetal population is naturally maintained by consistently cycling between Ixodid ticks and small vertebrates. To survive within these diverse niches, B. burgdorferi has evolved a unique physiology and regulatory network to sense and respond to environmental fluxes. Replication is a hallmark of the Lyme spirochete’s enzootic life cycle, specifically at the nymphal tick-to-vertebrate interface. The mechanisms and regulatory schema for the basic cellular processes in B. burgdorferi, or indeed any member of the phylum spirochaetota, are largely unknown. The central hypothesis …

Fathers’ Perspectives On The Role Of Spirituality In Substance Misuse Disorder Treatment And Engaging With Their Children, Kendra Michelle Eubank

Theses and Dissertations--Social Work

The father's role and the extent of involvement with his children have shifted over the past several decades. As a result, researchers have made considerable advances in understanding paternal influences on child development and families. However, one under-researched topic is how fathers' substance misuse, and the recovery process may influence father involvement and effective co-parenting, and specifically, how spirituality plays a role in that. In this qualitative study, fourteen participants participated in semi-structured interviews. The data revealed two main themes: 1) pillars of a spiritual awakening and 2) applying spirituality to healthy fatherhood engagement.

These findings led to four interpretations: …

Recovery Capital In A Justice-Involved Population: An Asset-Based Approach To Recovery And Community Reentry, Evan Joseph Batty

Theses and Dissertations--Sociology

The burden of the opioid epidemic demands further efforts to facilitate recovery, particularly for disadvantaged populations and those recently released from prison. After community reentry, individuals face a period of vulnerability as they adjust to new roles and responsibilities to meet their basic needs. Prison-based substance use disorder treatment (SUD Tx) programs provide support to help prepare individuals with SUD for their release and facilitate successful recovery goals after community reentry. This dissertation has three aims: (1) further the understanding of potential barriers and facilitators of recovery after community reentry, (2) assess how prison-levels of recovery capital influence recovery outcomes …

Sensitizing Keap1 Loss Non-Small Cell Lung Cancer To Artesunate Anti-Cancer Activity, Keng Hee Peh

Theses and Dissertations--Pharmacy

Lung cancer is the global leading cause of cancer related death. Non-small cell lung cancer (NSCLC) accounts for 80% of lung cancer diagnoses conferring a significant disease burden. However, certain mutations in tumor suppressors such as Kelch-like ECH-associated protein 1 (KEAP1) confers resistance to standard of care therapy in NSCLC. KEAP1 is known to regulate multiple cellular processes such as oxidative stress response and anti-apoptotic pathways. Furthermore, KEAP1 loss of function in NSCLC is associated with poorer clinical outcomes and there are no currently approved therapies for KEAP1 loss NSCLC and represents an unmet clinical need. Artesunate (Art) demonstrated anti-cancer …

The Determination Of Darcy Permeabilities And Slip Parameters In Porous Thermal Protection Media Via Pressure-Driven Steady Flows At Varying Levels Of Thermal Decomposition, John Ryan O'Nan

Theses and Dissertations--Mechanical and Aerospace Engineering

A flow apparatus for determining the Darcy permeability and Klinkenberg molecular slip adjustment parameter in arbitrary porous media was created. Two leak-proof methods were developed to secure samples of porous media in the flow apparatus independent of surface irregularities, structural integrity, or material porosity. The first of these methods uses thermoset resin casting to permit material samples of a highly irregular profile to be studied. The second method utilizes heat-shrink polyolefin tubing to create a wall seal while preserving the exposed faces of a given cylindrical sample, enabling the study of inhomogeneous surface features. These methods were used to characterize …

Artificial Intelligence Enabled Machinery Fault Detection And Diagnosis Using Vibro-Acoustic Signals, Srinivasa Rao Ippili

Theses and Dissertations--Mechanical and Aerospace Engineering

In various industries, the early detection of faults in rotating machinery is crucial to prevent system failures and ensure customer satisfaction. Typically, vibration measurement and diagnosis are employed for fault detection, but this process faces challenges in automation due to the complexity of installing and maintaining accelerometers, particularly in end-of-line quality control or pre-installed machinery health assessments. Acoustic signals, as a form of mechanical wave, offer an alternative for monitoring machinery while in operation. Unlike accelerometers, acoustic transducers are non-contact and easy to set up, enabling real-time data collection without interrupting equipment operation. However, utilizing acoustic signals in manufacturing poses …

High-Fidelity Coupling For Studies Of Ablative Materials At Hypersonic Conditions, Aleksander Zibitsker

Theses and Dissertations--Mechanical and Aerospace Engineering

The development of accurate models and robust numerical tools for simulating ablative thermal protection materials (TPMs) in hypersonic flows is crucial for advancing atmospheric entry and hypersonic technologies. Traditional methods for simulating ablative materials often rely on heavy assumptions, such as equal heat and mass transfer coefficients and chemical equilibrium in the boundary layer, leading to conservative thermal protection system (TPS) designs and insufficient accuracy for certain in-flight ablation phenomena.

This work presents a high-fidelity and versatile coupled framework between hypersonic flow and material response solvers. The flow domain is modeled with an innovative overset CHAMPS NBS-Cart solver, which features …

A Hyphenated Career: Sustainable Pathways For Dancers, Rebecca A. Ferrell

Theses and Dissertations--Arts Administration

Despite the rich cultural and artistic contributions of dancers, there exists a pressing need to comprehensively address the challenges and complexities surrounding the sustainability of careers in dance due to underemployment, underpayment, data undercounting and physical strain. This dissertation research aims to understand occupational trajectories that build a sustainable career for dancers. Through a historical examination of the professionalization of dance and an investigation of current career opportunities, this study investigates the growing support systems for dancers, the influence of occupational identity, and the workplace environments needed to sustain a dance career.

Occupational identity theory, motivation-hygiene theory, and transaction cost …

Three Contemporary Prosecution Case Studies And The Challenges Affecting The Indian Arts And Crafts Act, Tiffini Bowers

Theses and Dissertations--Arts Administration

The Indian Arts and Crafts Act (IACA) is America’s only federal arts policy. This study explores the IACA and the challenges contemporary prosecution cases identify for arts stakeholders, along with the implementation and effectiveness since the 2010 Act, to understand better the social and public policy implications and challenges for arts stakeholders. A qualitative study using multiple legal case studies, document analysis, and semi-structured interviews, along with an elite theory theoretical framework, anchors the research. Findings support existing research by indicating the main challenge is the definition and complexity of Indian identity; additional significant findings that contribute to future policy …

Music For The People: Comparing Public Funding Models For Popular Music In Atlanta, Glasgow, And Toronto, Heather Mcdonald

Theses and Dissertations--Arts Administration

This dissertation explores the complex landscape of public funding policies for popular music across three cities: Atlanta, Glasgow, and Toronto. Through comparative case studies and qualitative research methods, this work explores the varying approaches each city takes towards funding popular music, including the social, economic, and political environments in which these funding policies have developed.

Through document reviews and interviews with key stakeholders, the dissertation highlights the differences in how public funding for popular music is approached in Glasgow, Atlanta, and Toronto and the broader context of how these policies were created. Using Multiple Streams Approach, the Five Streams Confluence …

Repolarizing Tumor-Associated Macrophages In Ovarian Cancer: A Novel Immunotherapeutic Approach, David Schweer

Theses and Dissertations--Clinical and Translational Science

Ovarian cancer, recognized for its high lethality and resistance to conventional immunotherapies, mandates innovative strategies to confront its intricate challenges. The tumor microenvironment (TME), orchestrated by tumor-associated macrophages (TAMs), assumes a pivotal role in disease progression, rendering TAMs an appealing therapeutic target. This study endeavors to explore the prospect of repolarizing TAMs from a protumor M2 phenotype to an antitumor M1 state, employing M1 macrophage-derived vesicles (MEVs) as a groundbreaking immunotherapeutic approach.

The primary objective is to investigate the capacity of M1 MEVs to repolarize M2 macrophages in vitro towards an anti-tumor M1-like phenotype. By inducing human macrophages to adopt …

Evaluation Of The Cellular And Physiologic Impact Of Mitomycin C On Colon Cancer, Hannah Mcdonald

Theses and Dissertations--Clinical and Translational Science

Cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC) with Mitomycin C (MMC) has more than doubled the overall and disease-free survival in patients with peritoneal metastases (PM) due to colorectal cancer (CRC) over the past two decades. Although MMC is the most used HIPEC drug for PM due to CRC, dosing protocols vary dramatically between and within institutions across the world. Additionally, little is known about the impact of hyperthermia and MMC on intracellular pathways for CRC. The aim of this work is to determine the optimal dosing strategy in the clinical application of MMC and hyperthermia for treatment of …