Digital Commons Network^™

The Association Of Persistent Symptoms Of Depression And Anxiety With Recurrent Acute Coronary Syndrome Events: A Prospective Observational Study, Abdullah S. Alhurani, Ayman M. Hamdan-Mansour, Muayyad M. Ahmad, Gabrielle Mckee, Sharon O’Donnell, Frances O’Brien, Mary Mooney, Zyad T. Saleh, Debra K. Moser

Nursing Faculty Publications

The purpose of this study was to examine the role of persistent symptoms of depression and anxiety in a second acute coronary syndrome (ACS) event. Data presented in this study were from an RCT study. A follow-up for 24 months after baseline to detect a second ACS event among 1162 patients from five hospitals. Hierarchal Cox regression analyses were used. The results showed that persistent depression only (HR 2.27; 95% CI: 1.35–3.81; p = 0.002), and comorbid persistent depression and anxiety (HR 2.03; 95% CI: 1.03–3.98; p = 0.040) were the significant predictors of a second ACS event. Secondary education …

Ispe-Endorsed Guidance In Using Electronic Health Records For Comparative Effectiveness Research In Covid-19 Opportunities And Trade-Offs, Grammati Sarri, Dimitri Bennett, Thomas P. A. Debray, Anouk Deruaz-Luyet, Montse Soriano Gabarró, Joan A. Largent, Xiaojuan Li, Wei Liu, Jennifer L. Lund, Daniela Claudia Moga, Mugdha Gokhale, Christopher T. Rentsch, Xuerong Wen, Chen Yanover, Yizhou Ye, Huifeng Yun, Andrew R. Zullo, Kueiyu Joshua Lin

Pharmacy Practice and Science Faculty Publications

As the scientific research community along with healthcare professionals and decision makers around the world fight tirelessly against the coronavirus disease 2019 (COVID-19) pandemic, the need for comparative effectiveness research (CER) on preventive and therapeutic interventions for COVID-19 is immense. Randomized controlled trials markedly under-represent the frail and complex patients seen in routine care, and they do not typically have data on long-term treatment effects. The increasing availability of electronic health records (EHRs) for clinical research offers the opportunity to generate timely real-world evidence reflective of routine care for optimal management of COVID-19. However, there are many potential threats to …

Similarly Efficacious Anti-Malarial Drugs Sj733 And Pyronaridine Differ In Their Ability To Remove Circulating Parasites In Mice, Arya Sheelanair, Aleksandra S. Romanczuk, Rosemary A. Aogo, Rohit Nemai Haldar, Lianne I. M. Lansink, Deborah Cromer, Yandira G. Salinas, R. Kiplin Guy, James S. Mccarthy, Miles P. Davenport, Ashraful Haque, David S. Khoury

Pharmaceutical Sciences Faculty Publications

BACKGROUND: Artemisinin-based combination therapy (ACT) has been a mainstay for malaria prevention and treatment. However, emergence of drug resistance has incentivised development of new drugs. Defining the kinetics with which circulating parasitized red blood cells (pRBC) are lost after drug treatment, referred to as the "parasite clearance curve", has been critical for assessing drug efficacy; yet underlying mechanisms remain partly unresolved. The clearance curve may be shaped both by the rate at which drugs kill parasites, and the rate at which drug-affected parasites are removed from circulation.

METHODS: In this context, two anti-malarials, SJ733, and an ACT partner drug, pyronaridine …

Tracing The Path Of Technology Diffusion: The Case Of Nturumenti, Narok, Kenya, Paul N. Katiku, R. Kimitei, S. Amboga, G. A. Keya, B. Korir, J. Nginyi

IGC Proceedings (1977-2023)

An array of technologies; growing improved wheat varieties, bulking and collective marketing of wheat grains, sheep breed improvement, ram sharing, feedlot sheep fattening for market, strategic sheep deworming, pasture establishment and conservation practices; were introduced to members of a community based organization (CBO) in Nturumenti, anti-female genital mutilation and anti-poverty organization (AFAPO) in 2014. The CBO members, composed of youthful 19 men and 7 females, were intensively exposed and involved in the new skills both theoretically and practically in the farmers’ field school model. Even though the 8 farming technology options were suitable for the study environment, their adoption and …

Promoting Rangeland Restoration And Climate Resilience Through Grazing Case Studies, T. D. Hudson, S. A. Hall, G. G. Yorgey, S. Neibergs, M. R. Reeves, S. Jensen

IGC Proceedings (1977-2023)

Cow-calf beef operations are the primary users of the 8.75 million hectares of rangelands in the U.S. Pacific Northwest and will have to adapt to ongoing and future climate change. Management directed toward current rangeland stressors which may be amplified under a changing climate—including fire risk, invasive plants, and droughts—is likely to improve future resilience. And although climate change discussions have become highly politicized, our experience suggests that Pacific Northwest ranchers support "no-regrets” strategies that provide ecological and economic benefits under a variety of future conditions. Our goal is to foster adoption of these strategies by sharing individual success stories. …

The Effects Of Microbial Inoculation On Short-To-Long Fermentation And Aerobic Stability Of Grass-Legume Silage Ensiled In Big Bales, J. Jatkauskas, V. Vrotniakiene, K. L. Witt, G. Copani, I. Eisner

IGC Proceedings (1977-2023)

Wilted (35.9 % DM and 2.6% WSC) moderately difficult to ensile grass-legume mixture (red clover, alfalfa and timothy 50:20:30) was ensiled in cylindrical big bales (1.2 m hight and 1.2 m diameter) with a weight about 700 kg. The crop was ensiled for 8, 32 and 120 days with or without a microbial inoculation (SiloSolve^® FC containing Lactococcus lactis DSM 11037/1k2081 and Lactobacillus buchneri DSM 22501/1k20738 applied at 1.5×10⁵ CFU g^-1 forage). Ten bales per treatment were prepared for each fermentation period. After each period of ensiling the big bales were opened, sampled, and tested for fermentation …

Review Of Urochloa Breeder’S Toolbox With The Theory Of Change And Stage Gate System Approach, E. Sweitzer, L. Hernandez, D. Florian, A. Notenbaert, S. Burkart, J. Arango, J. Cardoso, M. Peters, V. Castiblanco

IGC Proceedings (1977-2023)

Livestock production in the global south is at crossroads as there is a demand to increase Animal Source Foods to address hunger and pressure to lighten the environmental footprint often associated with livestock production. To satisfy both needs, the use of technologies that improve animal performance, while reducing land use and net Greenhouse Gas emissions produced by animals is essential. One of such technologies are Urochloa forage grasses.

Urochloa forage grasses are well known for their rusticity and their ability to grow in soils of low fertility and high aluminum content. These characteristics allow Urochloa to grow in areas temporally …

The Low Abundance Of Cpg In The Sars-Cov-2 Genome Is Not An Evolutionarily Signature Of Zap, Ali Afrasiabi, Hamid Alinejad-Rokny, Azad Khosh, Mostafa Rahnama, Nigel Lovell, Zhenming Xu, Diako Ebrahimi

Plant Pathology Faculty Publications

The zinc finger antiviral protein (ZAP) is known to restrict viral replication by binding to the CpG rich regions of viral RNA, and subsequently inducing viral RNA degradation. This enzyme has recently been shown to be capable of restricting SARS-CoV-2. These data have led to the hypothesis that the low abundance of CpG in the SARS-CoV-2 genome is due to an evolutionary pressure exerted by the host ZAP. To investigate this hypothesis, we performed a detailed analysis of many coronavirus sequences and ZAP RNA binding preference data. Our analyses showed neither evidence for an evolutionary pressure acting specifically on CpG …

A Cluster Randomized Controlled Trial For A Multi-Level, Clinic-Based Smoking Cessation Program With Women In Appalachian Communities: Study Protocol For The "Break Free" Program, Joanne G. Patterson, Tia N. Borger, Jessica L. Burris, Mark Conaway, Robert Klesges, Amie Ashcraft, Lindsay Hauser, Connie Clark, Lauren Wright, Sarah Cooper, Merry C. Smith, Mark B. Dignan, Stephenie Kennedy-Rea, Electra D. Paskett, Roger Anderson, Amy K. Ferketich

Psychology Faculty Publications

BACKGROUND: The cervical cancer burden is high among women living in Appalachia. Cigarette smoking, a cervical cancer risk factor, is also highly prevalent in this population. This project aims to increase smoking cessation among women living in Appalachia by embedding a smoking cessation program within a larger, integrated cervical cancer prevention program.

METHODS: The broader program, the Take CARE study, is a multi-site research collaborative designed to address three risk factors for cervical cancer incidence and mortality: tobacco use, human papillomavirus (HPV) infection, and cervical cancer screening. Break Free is a primary care clinic-based implementation program that aims to promote …

Prevention Is Political: Political Party Affiliation Predicts Perceived Risk And Prevention Behaviors For Covid-19, Marc T. Kiviniemi, Heather Orom, Jennifer L. Hay, Erika A. Waters

Health, Behavior & Society Faculty Publications

BACKGROUND: Many US politicians have provided mixed messages about the risks posed by SARS-CoV-2/COVID-19 and whether and to what extent prevention practices should be put in place to prevent transmission. This politicization of the virus and pandemic may affect individuals' risk perceptions and willingness to take precautions. We examined how political party affiliation relates to risk perception for one's own and other people's likelihood of SARS-CoV-2 infection/COVID-19 illness.

METHODS: We surveyed members of a nationally-representative, probability-sampling based survey panel (N = 410) to examine their risk perceptions, precautionary behaviors, and political party affiliation.

RESULTS: The more strongly one identified …

A Cluster Randomized Controlled Trial For A Multi-Level, Clinic-Based Smoking Cessation Program With Women In Appalachian Communities: Study Protocol For The “Break Free” Program, Joanne G. Patterson, Tia N. Borger, Jennifer L. Burris, Mark Conaway, Robert Klesges, Amie Ashcraft, Lindsay Hauser, Connie Clark, Lauren Wright, Sarah Cooper, Merry C. Smith, Mark Dignan, Stephenie Kennedy-Rea, Electra D. Paskett, Roger Anderson, Amy K. Ferketich

Psychology Faculty Publications

Background: The cervical cancer burden is high among women living in Appalachia. Cigarette smoking, a cervical cancer risk factor, is also highly prevalent in this population. This project aims to increase smoking cessation among women living in Appalachia by embedding a smoking cessation program within a larger, integrated cervical cancer prevention program.

Methods: The broader program, the Take CARE study, is a multi-site research collaborative designed to address three risk factors for cervical cancer incidence and mortality: tobacco use, human papillomavirus (HPV) infection, and cervi‑ cal cancer screening. Break Free is a primary care clinic-based implementation program that …

Reviewer Acknowledgments, F. Douglas Scutchfield Md, Charlotte S. Seidman, Robert M. Shapiro Ii

Journal of Appalachian Health

We offer these reviewers our heartfelt thanks for a task that usually goes unrewarded in the academic environment. This year, we are especially grateful for those people listed below. They have assisted us in reaching the start of our 4th year, by guiding our decisions with your knowledge and capabilities.

Review Of: Wide Neighborhoods: A Story Of The Frontier Nursing Service, Tauna Gulley Phd

Journal of Appalachian Health

The Journal of Appalachian Health is committed to reviewing published media that relates to contemporary concepts affecting the health of Appalachia. Access to care remains one of the biggest challenges to Appalachian Health. The book, Wide Neighborhoods: A Story of the Frontier Nursing Service by Mary Breckinridge, is a well-known title that seems as relevant today as it was in 1952.

Prevalence And Types Of Drugs Used Among Hepatitis A Patients During Outbreaks Associated With Person-To-Person Transmission, Kentucky, Michigan, And West Virginia, 2016–2019, Megan G. Hofmeister, Alice Asher, Christopher M. Jones, Ryan J. Augustine, Cole Burkholder, Jim Collins, Monique A. Foster, Shannon Mcbee, Erica D. Thomasson, Doug Thoroughman, Mark K. Weng, Philip R. Spradling

Journal of Appalachian Health

Background: People who use drugs are at increased risk for hepatitis A virus infection. Since 1996, the Advisory Committee on Immunization Practices has recommended hepatitis A vaccination for people who use drugs. Since 2016, the U.S. has experienced widespread hepatitis A outbreaks associated with person-to-person transmission.

Purpose: To describe the prevalence of drug use, route of use, and drugs used among hepatitis A outbreak-associated patients.

Methods: State outbreak and medical records were reviewed to describe the prevalence, type, and route of drug use among a random sample of 812 adult outbreak-associated hepatitis A patients from Kentucky, Michigan, and West Virginia …

Changes In Adolescent Birth Rates Within Appalachian Subregions And Non-Appalachian Counties In The United States, 2012–2018, Nathan Hale, Kathleen Tatro, Sylvester Olubolu Orimaye, Michael Smith, Michael Meit, Kate E. Beatty, Amal Khoury

Journal of Appalachian Health

Background: Adolescent births are associated with numerous challenges. While adolescent birth rates have declined across the U.S., disparities persist and little is known about the extent to which broader declines are seen within Appalachia.

Purpose: The purpose of this study was to examine the extent to which adolescent birth rates have declined across the subregions of Appalachia relative to non-Appalachia.

Methods: We conducted a retrospective study of adolescent birth rates between 2012 and 2018 using county-level vital records data. Differences were examined across the subregions of Appalachia and among non-Appalachian counties. Multiple regression models were used to examine changes in …

Community Strengths And Challenges Related To Opioid Use Disorder In Rural Counties Of East Tennessee, Ashlyn N. Schwartz, Zeruiah V. Buchanan, Laurie L. Meschke

Journal of Appalachian Health

Introduction: Appalachia, particularly Rural East Tennessee, has been and continues to be disproportionately impacted by opioid use disorder and its many tragic ramifications.

Purpose: Community-engaged strategies can inform and support the development of relevant prevention efforts. Hence, people connected to a ten-county rural Appalachian region in East Tennessee were asked to identify and prioritize strengths and challenges related to opioid use disorder (OUD).

Methods: Adult community members (n=577) completed a brief survey administered across 11 days in 2019.

Results: Of the respondents, 85.3% never had been addicted to opioids, but 74.0% had someone close to them with OUD. The most …

They Built My Soul: A Qualitative Analysis Of The Impacts Of Home Repairs In Rural Tennessee, Bethesda O'Connell, Ada Sloop, Nicole Intagliata, Melisa Miller, Megan Quinn

Journal of Appalachian Health

Background: Housing is an important social determinant of health and substandard housing is linked to physical, mental, and social health problems.

Purpose: The purpose of the study was to qualitatively assess the impacts of repairs to substandard housing in rural East Tennessee through twenty-eight interviews.

Methods: Zoom was utilized for recording phone interviews in January– February 2021 and NVivo software was used for thematic analysis in May–July 2021.

Results: Themes that emerged included environmental risk reduction, impacts on physical health, impacts on mental health, impacts on financial well-being, and willingness to receive future assistance from service organizations.

Implications: Further …

That's All She Wrote, Charlotte S. Seidman

Journal of Appalachian Health

With the publication of this issue, I am retiring and formally handing over the reins as managing editor of the Journal of Appalachian Health to Rachel Dixon. I have had a 50+ year career and have been blessed to have had the opportunity to meet and work with the best health professionals in preventive medicine and public health.

Change Happens, F. Douglas Scutchfield Md

Journal of Appalachian Health

The Journal of Appalachian Health is going through some changes that are reflected in the masthead and banner. We say farewell to some colleagues and welcome the new faces.

More Elevated Fastballs Associated With Placement On The Injured List Due To Shoulder Injury, Austin V. Stone, Brooks N. Platt, Brandon S. Collofello, Aaron D. Sciascia, Timothy L. Uhl, William B. Kibler

Orthopaedic Surgery and Sports Medicine Faculty Publications

Purpose

To evaluate whether impending shoulder injury was associated with changes in pitch location or velocity immediately preceding injury.

Methods

Pitchers placed on the injured list (IL) due to a shoulder injury between 2015 and 2020 were identified in the Major League Baseball transactions database. Four-seam fastball velocity and frequency of pitch location for each pitch type was collected for each player in the season before placement on the IL and within 1 month of placement on the IL with a minimum of 55 pitches thrown of 1 type. Pitch locations were collected as identified by Baseball Savant’s Game-Day Zones. …

Participatory Evaluation Of Urochloa And Megathyrsus Forage Species In Western Kenya: Farmers Perspective, Ruth Odhiambo, Solomon Mwendia, David Mwangi, Alfred Juma, An Notenbaert

IGC Proceedings (1977-2023)

Despite western Kenya potential in dairy production, it has lagged behind compared to other regions in the country. This comes against growing per capita milk consumption in Kenya currently estimated at 120 litres per person per year. As a result, western Kenya is largely net importer of milk from neighbouring counties albeit the possibility improving productivity within. Among the most prevalent constraint to increased productivity is limited forage quality and quantity throughout the year. Napier stunting disease, which suppresses forage production from Napier grass, the most prevalent cultivated forage in western Kenya, exacerbates this. To contribute to addressing the problem, …

Nutritional Quality Of Available Forages For Small Stock During A Drought In An Arid Pastoral Landscape In South Africa, M. I. Samuels, F. L. Müller, C. F. Cupido, M. B. V. Swarts, L. F. Cyster

IGC Proceedings (1977-2023)

This study aimed to assess the nutritional quality of the available forage species during a drought in an arid pastoral system in South Africa. Forage biomass was collected during the wet and dry seasons whilst following livestock herds consisting of boer goats, swakara sheep and mixed breed sheep, in both the summer and winter rainfall regions of the pastoral system. Mineral nutrient content in the plant species revealed that the forages utilized by the livestock generally contained adequate concentrations of Mg, Ca, Na, and K to meet the dietary requirements of the small stock in both the winter and summer …

Mineral Profile Of Panicum Maximum Var. Ntchisi As Influenced By Organic Nitrogen Rate And Age At Harvest, P. Dele, B. Akinyemi, O. Oyeleke, C. Anotaenwere, F. Salawu, S. O. Onifade

IGC Proceedings (1977-2023)

The study was aimed at profiling the mineral contents of Panicum maximum var Ntchisi as influenced by organic (poultry) nitrogen rate and age at harvest. The study was carried out at the organic research farm of the Federal University of Agriculture, Abeokuta, Nigeria in 2016. The experiment was laid in a 4 x 3 factorial arrangement in a split plot design with four (4) organic nitrogen rate (0, 100, 200 and 300 kgNha^-1) as the main plot and three (3) age at harvest (4, 8 and 12 weeks after cutback) as the subplot which amounts to twelve (12) …

Nutritional Characterisation Of Introduced Improved Brachiaria Grasses In Rwanda, M. Mutimura, P. C. Hitimana

IGC Proceedings (1977-2023)

A study aimed at characterising nutritive value of introduced Brachiaria grasses in Rwanda was conducted. Four Brachiaria grasses including, Brachiaria decumbens cv. Basilisk, Brachiaria brizantha cv. MG4, Brachiaria brizantha cv. Piata and Brachiaria cv. Cayman with Panicum coloratum as control were planted in two contrasting environments of low rainfall in Kirehe district and acidic soils in Nyamagabe district. The experiment was set in a randomized complete block design (RCBD) with four replications and the treatments were harvested after 60 days and 90 days. Data collected were dry matter (DM), crude proteins (CP), organic matter (OM), cellulose, neutral detergent fibre (NDF), …

Clinical Geography: A Commentary Response, Jessica M. Finlay, Graham D. Rowles

Graduate Center for Gerontology Faculty Publications

No abstract provided.

Strategy For Conjugating Oligopeptides To Mesoporous Silica Nanoparticles Using Diazirine-Based Heterobifunctional Linkers, Md Arif Khan, Ramy W. Ghanim, Maelyn R. Kiser, Mahsa Moradipour, Dennis T. Rogers, John M. Littleton, Luke H. Bradley, Bert C. Lynn, Stephen E. Rankin, Barbara L. Knutson

Chemical and Materials Engineering Faculty Publications

Successful strategies for the attachment of oligopeptides to mesoporous silica with pores large enough to load biomolecules should utilize the high surface area of pores to provide an accessible, protective environment. A two-step oligopeptide functionalization strategy is examined here using diazirine-based heterobifunctional linkers. Mesoporous silica nanoparticles (MSNPs) with average pore diameter of ~8 nm and surface area of ~730 m²/g were synthesized and amine-functionalized. Tetrapeptides Gly-Gly-Gly-Gly (GGGG) and Arg-Ser-Ser-Val (RSSV), and a peptide comprised of four copies of RSSV (4RSSV), were covalently attached via their N-terminus to the amine groups on the particle surface by a heterobifunctional linker, …

Potential Of C4 Tropical Grasses To Contribute In Carbon Sequestration, Environmental Security And Livelihood Opportunities Through Increased Fodder Availability, D. R. Malaviya, A. K. Roy, P. Kaushal

IGC Proceedings (1977-2023)

The world grasslands/rangeland ecosystems comprise 26% of earth’s surface and have immense ecological and economic significance. Diversity of grasslands had been a key element for their sustainability. Grasslands in India have existed as natural ecosystems for millions of years. It is a major source of income, employment and livelihood to the rural families. Owing to heavy grazing pressure, coupled with other social/anthropogenic factors, the grazing resources have fast deteriorated. The country has many old and natural grasslands with ethnic and economic value. Comprehensive ecological studies including floristic compositions, dominant species, grazing pressure and the climax/sub-climax stages of ecological succession will …

Microbiome Of The Cool Season Forage Grass Timothy (Phleum Pratense L.) And Its Potential Role In Stress Tolerance, Dina Saleh, Suha Jabaji, Philippe Seguin

IGC Proceedings (1977-2023)

The functional attributes of the microbiome associated with timothy for growth promotion properties, antimicrobial and biosurfactant capacities were characterized. A total of 254 culturable bacteria were identified by 16S rRNA sequencing and grouped into 16 taxa that shared high homology of 98–99% with other known sequences. The majority of bacterial isolates exhibited multifunctional growth promotion attributes and plant stress improvement. The selection of competent and compatible strains for application in forage production is dependent on the recognition of root exudates and motility towards the roots, attachment to the root surface, formation of biofilm, penetration, and colonization of internal tissues. We …

Improving The Functionality Of Water Investments In The Drylands: Learning From Kenya’S County Climate Change Fund, C. Bedelian, M. Bonaya, A. Ibrahim, F. Ngarachu, C. Hesse

IGC Proceedings (1977-2023)

Kenya’s County Climate Change Fund (CCCF) is financing public good investments focused on the water sector to increase the resilience of communities to climate change. In the drylands, investments in water are critical for water and food security, yet ensuring the functionality and sustainability of water investments remains an ongoing challenge. This paper assesses the functionality and sustainability of 62 CCCF water investments in five dryland counties (Isiolo, Wajir, Garissa, Kitui and Makueni) in Kenya through a functionality survey and stakeholder workshops. The survey was designed based on a review of studies assessing the functionality of water supply systems. Across …

Long-Read Sequencing Of The Zebrafish Genome Reorganizes Genomic Architecture, Yelena Chernyavskaya, Xiaofei Zhang, Jinze Liu, Jessica S. Blackburn

Molecular and Cellular Biochemistry Faculty Publications

BACKGROUND: Nanopore sequencing technology has revolutionized the field of genome biology with its ability to generate extra-long reads that can resolve regions of the genome that were previously inaccessible to short-read sequencing platforms. Over 50% of the zebrafish genome consists of difficult to map, highly repetitive, low complexity elements that pose inherent problems for short-read sequencers and assemblers.

RESULTS: We used long-read nanopore sequencing to generate a de novo assembly of the zebrafish genome and compared our assembly to the current reference genome, GRCz11. The new assembly identified 1697 novel insertions and deletions over one kilobase in length and placed …