Digital Commons Network^™

Age Adjusted Comorbidity Risk Index Does Not Predict Outcomes In An Autologous Hematopoietic Stem Cell Transplant Population, Dylan Barth, Michael Singleton, Gregory Monohan, Brian Mcclune, Val Adams

Pharmacy Practice and Science Faculty Publications

The hematopoietic comorbidity risk index (HCT-CI) is a pre-transplant risk assessment tool used to prognosticate morbidity and mortality of patients undergoing allogeneic hematopoietic stem cell transplantation. Recently, the HCT-CI was updated to include an age component (HCT-CI-age). Although other studies have validated this tool in allogeneic stem cell transplant recipients, it has never been studied in an autologous transplant patient population. We retrospectively reviewed 181 patients who underwent their first autologous hematopoietic stem cell transplant. We aimed (1) to assess whether an HCT-CI score of 3 or greater is associated with greater mean transplant hospital days, greater total hospital days, …

Editorial: Individual Differences In Cognition And Affects In The Era Of Pandemic And Machine Learning, Andrea Vranic, Yang Jiang, Xiaopeng Zhao

Behavioral Science Faculty Publications

No abstract provided.

Subsequent Ultrasonographic Non-Visualization Of The Ovaries Is Hastened In Women With Only One Ovary Visualized Initially, Edward J. Pavlik, Hannah Fancher, Charles S. Dietrich, John R. Van Nagell Jr.

Obstetrics and Gynecology Faculty Publications

Because the effects of age, menopausal status, weight and body mass index (BMI) on ovarian detectability by transvaginal ultrasound (TVS) have not been established, we determined their contributions to TVS visualization of the ovaries when one or both ovaries are visualized on the first ultrasound exam. A total of 29,877 women that had both ovaries visualized on their first exam were followed over 202,639 prospective TVS exams and 9703 women that had only one ovary visualized on their first exam were followed over 63,702 ultrasonography exams. All images were reviewed by a physician. While non-visualization of both ovaries increased with …

An Analysis Of Community-Based Values Informing Land Management On The Midwestern Prairie Band Potawatomi Nation Of Kansas, Usa, Heidi Mehl, Diana L. Restrepo-Osorio, Melinda Howard, Cynthia Annett

IGC Proceedings (1977-2023)

The focus of this study is to examine the interface between land management practices and values within a tribal community in rural midwestern North America. The Prairie Band Potawatomi Nation (PBPN) reside on a tribal reservation with a checkerboard distribution amongst private, non-tribal landowners. Previous studies have indicated that landowners may have different value-systems leading to variations in land-management practices. This can impose discontinuous land management in areas within shared biological boundaries, such as watersheds, especially between tribal and non-tribal entities. Preliminary spatial analysis in and around the PBPN landscape determined that the tribally-managed lands present more vegetative cover per …

A Policy Brief On Adopting The Somali Camel For Enhanced Profitability And Pastoral Resilience In Northern Kenya, Simon G. Kuria, A. O. Adongo, S. Murithi, O. K. Koech, J. T. Njoka, P. Kamande

IGC Proceedings (1977-2023)

Persistent drought and high temperatures in Isiolo and Marsabit counties of northern Kenya repeatedly devastate livestock herds particularly cattle making the pastoralists less resilient, more vulnerable to climate change and poor. To address this challenge, an IGAD funded project promoted adoption of Somali camel breed, trained farmers on improved management and also estimated potential profitability of rearing the camel. Through the project, trainers were trained and facilitated to train 240 peri-urban Somali camel producers in Isiolo and Marsabit on breeding, health, routine husbandry and marketing. Impact study documenting positive stories of change was conducted at the end. Producers who hitherto …

Structural Features Of Condensed Tannins Influence Their Antimethanogenic Potential In Forage Plants, S. Verma, J.-P. Salminen, S. Wolffram, F. Taube, R. Blank, A. Susenbeth, C. Malisch

IGC Proceedings (1977-2023)

Despite years of research on the antimethanogenic potential of condensed tannins (CT), their large-scale application is inhibited by a substantial variability in previous studies with regards to their impact on ruminant nutrition. This variability mainly results from the complexity of CT structures, and their impact on methane emissions is often unaccounted for. Hence, this study (a) evaluated the variability in antimethanogenic potential across six forage species, (b) linked methane emissions to tannin activity, and (c) determined the impact of CT structural features on methane abatement. Six forage species were grown in a greenhouse under controlled environmental conditions, namely, sainfoin ( …

Optimizing Quality With Bale Density And Time Of Wrapping, Jessica Williamson

Kentucky Alfalfa and Stored Forage Conference

No abstract provided.

Variable Anterior Segment Dysgenesis And Cardiac Anomalies Caused By A Novel Truncating Variant Of Foxc1, Mariya R. Ahmed, Saumil Sethna, Laura A. Krueger, Michael B. Yang, Robert B. Hufnagel

Biology Graduate Research

Anterior segment dysgenesis (ASD) encompasses a wide spectrum of developmental abnormalities of the anterior ocular segment, including congenital cataract, iris hypoplasia, aniridia, iridocorneal synechiae, as well as Peters, Axenfeld, and Rieger anomalies. Here, we report a large five-generation Caucasian family exhibiting atypical syndromic ASD segregating with a novel truncating variant of FOXC1. The family history is consistent with highly variable autosomal dominant symptoms including isolated glaucoma, iris hypoplasia, aniridia, cataract, hypothyroidism, and congenital heart anomalies. Whole-exome sequencing revealed a novel variant [c.313_314insA; p.(Tyr105*)] in FOXC1 that disrupts the α-helical region of the DNA-binding forkhead box domain. In vitro studies …

Integration Of Liquid Biopsy And Pharmacogenomics For Precision Therapy Of Egfr Mutant And Resistant Lung Cancers, Jill M. Kolesar, Spencer Peh, Levin Thomas, Gayathri Baburaj, Nayonika Mukherjee, Raveena Kantamneni, Shirley Lewis, Ananth Pai, Karthik S. Udupa, Naveena Kumar An, Vivek M. Rangnekar, Mahadev Rao

Pharmacy Practice and Science Faculty Publications

The advent of molecular profiling has revolutionized the treatment of lung cancer by comprehensively delineating the genomic landscape of the epidermal growth factor receptor (EGFR) gene. Drug resistance caused by EGFR mutations and genetic polymorphisms of drug metabolizing enzymes and transporters impedes effective treatment of EGFR mutant and resistant lung cancer. This review appraises current literature, opportunities, and challenges associated with liquid biopsy and pharmacogenomic (PGx) testing as precision therapy tools in the management of EGFR mutant and resistant lung cancers. Liquid biopsy could play a potential role in selection of precise tyrosine kinase inhibitor (TKI) therapies during different phases …

Editorial: Anticancer Potential Of Artemisia Annua, Jill M. Kolesar, Peter H. Seeberger

Pharmacy Practice and Science Faculty Publications

No abstract provided.

Management Of Infective Endocarditis In Pregnancy By A Multidisciplinary Team: A Case Series, Kayle S. Shapero, Varidhi Nauriyal, Christina Megli, Kathryn Berlacher, Sami El-Dalati

Internal Medicine Faculty Publications

Introduction: The incidence of infective endocarditis (IE) in pregnancy is rare and has been increasing during the opioid epidemic. IE in pregnancy is associated with high rates of maternal and fetal morbidity and mortality. Multidisciplinary endocarditis teams for management of IE have been shown to reduce in-hospital and 1-year mortality. We present a single-center experience managing IE in pregnancy utilizing a multidisciplinary endocarditis team.

Methods: Patients diagnosed with IE while pregnant or within 30 days post-partum were identified. All patients discussed at the institution's weekly multidisciplinary endocarditis meeting were included. Demographic and clinical data and outcome-related variables were retrospectively reviewed …

Prevalence And Correlates Of Invitation To Participate In Clinical Trials Among Us Adults, Aurora Occa, Allison Leip, Allison S. Merritt, Jerod L. Stapleton

Communication Faculty Publications

Clinical trials are essential to modern medicine, but several barriers, including poor communication, hamper their successful completion. We examined the prevalence and correlates of invitation to participate in clinical trials among a nationally-representative sample of US adults using survey responses from the 2020 HINTS (Cycle 5). Analyses were conducted in 2021.

Overall, 9% of respondents reported being invited to a clinical trial, a prevalence that is nearly half of previously reported rates in convenience samples recruited from health care settings. Compared to non-Hispanic Whites, Black respondents reported the higher prevalence of invitation (16.0%) whereas Asian respondents reported the lowest (2%). …

Intellectual Property Protection – Stimulating Or Constraining Innovation And Technology Transfer?, John R. Caradus, C. A. Tumilson, J. Y. Lin

IGC Proceedings (1977-2023)

Grassland farming is becoming more technically advanced leading to improvements in productivity, environmental outcomes and animal welfare. As a result, farmers have an increasing range of new innovations being made available to them. The question examined here is whether widespread uptake of new innovations by farmers is more effective when driven by marketing through dedicated paths to market where the intellectual property (IP) is controlled or through multiple paths to market where there is no IP control?

The role of IP in stimulating the development, manufacture and sale of new technologies is hotly debated. For plant breeders and patent owners, …

High Altitude Rangelands And Pastoralism In Bhutan: Using Sustainable Development Goals To Address Land Degradation And Poverty, J. E. Millar, K. Tenzing

IGC Proceedings (1977-2023)

Semi-nomadic pastoralists in Bhutan live in high altitude rangelands where they seasonally migrate with yak and cattle herds from 3,000m to 5,000m. Population increase, overgrazing and climate change in eastern Bhutan have led to severe land degradation, winter fodder shortage and reduced milk production per head for herding families. This paper describes how Sustainable Development Goals (SDGs) were used to design a rangeland rehabilitation and livelihoods improvement program with herders in Merak district from 2016 to 2019. The aim was to restore degraded rangelands, improve pastures, develop savings schemes, resolve conflicts and increase conservation knowledge. The approach involved gender sensitive …

Long-Term Sustainability Implications Of Diverse Commercial Pollinator Mixtures For The Conservation Reserve Program, Amanda J. Ashworth, Taylor Adams, Alayna Jacobs

Plant and Soil Sciences Graduate Research

The persistence of Conservation Reserve Program (CRP) seed mixtures following planting is crucial for the long-term support of pollinator habitat; however, the role of disturbance regimes and their interactions in supporting this ecosystem service are largely unknown. This study set out to evaluate how ecological disturbances (prescribed burn, light disking, or fallow control) and commercially available diverse species mixtures (‘Hamilton’, ‘Bamert’, and ‘Holland’) affect pollinator habitat and the flowering period of commonly used CRP species mixtures. Specifically, three pollinator species mixtures were assessed for plant stand dynamics (plant density, yield, and dual-use pollinator-lignocellulosic feedstock potential); the resulting soil properties; and …

Sunburns And Sun Protection Behaviors Among Male Hispanic Outdoor Day Laborers, Zhaomeng Niu, Mary Riley, Jerod L. Stapleton, Michele Ochsner, Germania Hernandez, Daniel P. Giovenco, Shawna V. Hudson, Denalee O’Malley, Carolina Lozada, Marién Casillas Pabellón, Carolyn J. Heckman, Elliot J. Coups, Louis Kimmel

Health, Behavior & Society Faculty Publications

Individuals who work outside are at increased risk for skin cancer due to excessive exposure to ultraviolet (UV) radiation. Little is known about UV exposures and sun safety practices of outdoor day laborers, who are disproportionately Hispanic. This study identified the correlates of sunburn and sun protection behaviors in a sample of male, Hispanic day laborers (n = 175). More than half of the participants (54.9%) experienced one or more sunburns when working during the past summer, and 62.9% reported having one or more symptoms of heat illness. The frequency of engaging in sun protection behaviors was suboptimal, including …

Analysis Of The Attitude Of Farmers Towards Innovations In The Management Of Grasslands In Poland, P. Goliński, A. Van Den Pol-Van Dasselaar, A. Paszkowski, B. Golińska

IGC Proceedings (1977-2023)

Innovations in the management of grasslands in Poland are important to preserve them as a source of different ecosystem services. In the farmers point of view the most promising is forage production for herbivores, particularly dairy cows. Individual farmers have different opinions about innovations. To stimulate innovations in grassland-based farming systems in Poland, it is important to determine the drivers for their promotion and to define the barriers to overcome problems by their implementation. Analysis of the attitude of Polish farmers towards innovations on grasslands were conducted within the H2020 Inno4Grass project. The majority of respondents were young and had …

What Have We Learnt From Quantitative Case Reports Of Acute Lateral Ankle Sprains Injuries And Episodes Of 'Giving-Way' Of The Ankle Joint, And What Shall We Further Investigate?, Filip Gertz Lysdal, Yuehang Wang, Eamonn Delahunt, Dominic Gehring, Kyle B. Kosik, Tron Krosshaug, Yumeng Li, Kam-Ming Mok, Kati Pasanen, Alexandria Remus, Masafumi Terada, Daniel T. P. Fong

Athletic Training and Clinical Nutrition Faculty Publications

Lateral ankle sprains are a commonly incurred injury in sports. They have a high recurrence rate and can lead to the development of persistent injury associated symptoms. We performed a quantitative synthesis of published case reports documenting the kinematics of acute lateral ankle sprains and episodes of ‘giving-way’ of the ankle joint to provide a comprehensive description of the mechanisms. A systematic literature search was conducted to screen records within MEDLINE® and EMBASE®. Additional strategies included manual search of specific journals, as well as contacting researchers in relevant communities to retrieve unpublished data. Twenty-four cases were included in the quantitative …

Recent Advances In Probiotic Application In Animal Health And Nutrition: A Review, Sarayu Bhogoju, Samuel Nahashon

Internal Medicine Faculty Publications

Biotechnological advances in animal health and nutrition continue to play a significant role in the improvement of animal health, growth, and production performance. These biotechnological advancements, especially the use of direct-fed microbials, also termed probiotics, those genetically modified and otherwise, have minimized many challenges facing livestock production around the world. Such advancements result in healthy animals and animal products, such as meat, for a growing population worldwide. Increasing demand for productivity, healthy animals, and consumer food safety concerns, especially those emanating from excessive use of antibiotics or growth promoters, are a driving force for investing in safer alternatives, such as …

Emerging Evidence And Treatment Perspectives From Randomized Clinical Trials In Systemic Sclerosis: Focus On Interstitial Lung Disease, Caterina Oriana Aragona, Antonio Giovanni Versace, Carmelo Ioppolo, Daniela La Rosa, Rita Lauro, Maria Concetta Tringali, Simona Tomeo, Guido Ferlazzo, William Neal Roberts, Alessandra Bitto, Natasha Irrera, Gianluca Bagnato

Internal Medicine Faculty Publications

Systemic sclerosis (SSc) is a complex rare autoimmune disease with heterogeneous clinical manifestations. Currently, interstitial lung disease (ILD) and cardiac involvement (including pulmonary arterial hypertension) are recognized as the leading causes of SSc-associated mortality. New molecular targets have been discovered and phase II and phase III clinical trials published in the last 5 years on SSc-ILD will be discussed in this review. Details on the study design; the drug tested and its dose; the inclusion and exclusion criteria of the study; the concomitant immunosuppression; the outcomes and the duration of the study were reviewed. The two most common drugs used …

Imaging Techniques For Aortic Aneurysms And Dissections In Mice: Comparisons Of Ex Vivo, In Situ, And Ultrasound Approaches, Sohei Ito, Hong S. Lu, Alan Daugherty, Hisashi Sawada

Saha Cardiovascular Research Center Faculty Publications

Aortic aneurysms and dissections are life-threatening conditions that have a high risk for lethal bleeding and organ malperfusion. Many studies have investigated the molecular basis of these diseases using mouse models. In mice, ex vivo, in situ, and ultrasound imaging are major approaches to evaluate aortic diameters, a common parameter to determine the severity of aortic aneurysms. However, accurate evaluations of aortic dimensions by these imaging approaches could be challenging due to pathological features of aortic aneurysms. Currently, there is no standardized mode to assess aortic dissections in mice. It is important to understand the characteristics of each approach for …

Associations Between Potential Inflammatory Properties Of The Diet And Frequency, Duration, And Severity Of Migraine Headaches: A Cross-Sectional Study, Seyed Mojtaba Ghoreishy, Gholamreza Askari, Hamed Mohammadi, Marilyn S. Campbell, Fariborz Khorvash, Arman Arab

Kinesiology and Health Promotion Faculty Publications

Despite a large body of literature on the association between the dietary inflammatory index (DII) and various chronic diseases, limited knowledge is available regarding the association between DII and migraine. Therefore, we assessed the relationship between the DII and migraine characteristics, including duration, frequency, and severity of migraine headaches, Headache Impact Test-6 (HIT-6), and serum levels of nitric oxide (NO). This population-based cross-sectional study was conducted from August 2019 to June 2020 among 262 patients (38 men and 224 women; 20-50 years). A 168-item semiquantitative food frequency questionnaire (FFQ) was gathered to evaluate dietary intake, and subsequently, an energy-adjusted DII …

Utilizing Perennial Grass Species’ Population Patterns To Detect Looming Desertification Tipping Points In Semi-Arid Regions, F. Munyebvu-Chambara, W. C. Nesongano, M. C. Bilton, A. Linstädter

IGC Proceedings (1977-2023)

Namibia is one of the global dryland regions facing desertification threats due to overgrazing and recurrent drought. This has disastrous effects on forage provision and consequently on local livelihoods. Unfortunately, the mechanisms underlying sudden shifts of rangeland ecosystems towards a desertified state are still poorly understood. The ability to predict desertification tipping points with the aid of suitable ecological indicators is critical to ensure sustainable management of rangeland resources, which are a backbone of rural livelihood in drylands worldwide. Accordingly, we aimed to identify key perennial grass species that can be used as early-warning indicators for desertification tipping points; and …

How Much Margin Is Left For Degrading Agricultural Soils? The Coming Soil Crises, Maheteme Gebremedhin, Mark S. Coyne, Karamat R. Sistani

Plant and Soil Sciences Faculty Publications

Agricultural soils are in peril. Multiple lines of observational and empirical evidence suggest that we are losing the world’s fertile soils at an alarming rate, worsening the on-going global food crisis. It is increasingly clear that the risk of soil crises driven by erratic precipitation, warming air, and farming mismanagement is coming sooner rather than later. At this critical time, society cannot avoid looking for ways to curb soil crises. We argue that now is the right time for science-based mitigation strategies and new insights to protect soils. We offer four research priority areas that society needs to address. Arresting …

Rare Coding Variants In Rcn3 Are Associated With Blood Pressure, Karen Y. He, Tanika N. Kelly, Heming Wang, Jingjing Liang, Luke Zhu, Brian E. Cade, Themistocles L. Assimes, Lewis C. Becker, Amber L. Beitelshees, Lawrence F. Bielak, Adam P. Bress, Jennifer A. Brody, Yen-Pei Christy Chang, Yi-Cheng Chang, Paul S. De Vries, Ravindranath Duggirala, Ervin R. Fox, Nora Franceschini, Anna L. Furniss, Yan Gao, Donna K. Arnett

Epidemiology and Environmental Health Faculty Publications

BACKGROUND: While large genome-wide association studies have identified nearly one thousand loci associated with variation in blood pressure, rare variant identification is still a challenge. In family-based cohorts, genome-wide linkage scans have been successful in identifying rare genetic variants for blood pressure. This study aims to identify low frequency and rare genetic variants within previously reported linkage regions on chromosomes 1 and 19 in African American families from the Trans-Omics for Precision Medicine (TOPMed) program. Genetic association analyses weighted by linkage evidence were completed with whole genome sequencing data within and across TOPMed ancestral groups consisting of 60,388 individuals of …

Soil Carbon Accumulation Under Perennial Forage Grasses In The Southern Highlands Of Tanzania, S. S. Nyawira, P. Birthe, M. J. Korir, B. Nzogela, A. O. Notenbaert

IGC Proceedings (1977-2023)

Land degradation caused by the loss of SOC in continuously cultivated agricultural systems is a major problem in many sub-Saharan Africa countries. The integration on perennial forage grasses in cropping systems has the potential to enhance SOC sequestration. The main objective of this study is to compare soil organic carbon (SOC) under perennial forages with SOC under annual food crops, specifically maize (Zea mays). A survey was conducted in Njombe district in the Southern Highlands of Tanzania to identity farmers with planted forages that are more than five years old and with neighbouring maize plots. Survey results identified …

Rise Of Social Media Influencers As A New Marketing Channel: Focusing On The Roles Of Psychological Well-Being And Perceived Social Responsibility Among Consumers, Jihye Kim, Minseong Kim

Integrated Strategic Communication Faculty Publications

This empirical research investigated the structural relationships between social media influencer attributes, perceived friendship, psychological well-being, loyalty, and perceived social responsibility of influencers, focusing on the perspective of social media users. More specifically, this study conceptually identified social media influencer attributes such as language similarity, interest similarity, interaction frequency, and self-disclosure and examined the respective effects of each dimension on perceived friendship and psychological well-being, consequently resulting in loyalty toward social media influencers. The authors collected and analyzed data from 388 social media users in the United States via Amazon’s Mechanical Turk with multivariate analyses to test the hypothesized associations …

Sex Differences In Kappa Opioid Receptor Agonist Mediated Attenuation Of Chemotherapy-Induced Neuropathic Pain In Mice, Kelly F. Paton, Dan Luo, Anne C. La Flamme, Thomas E. Prisinzano, Bronwyn M. Kivell

Pharmaceutical Sciences Faculty Publications

Chemotherapy-induced neuropathic pain is a common side effect for cancer patients which has limited effective treatment options. Kappa opioid receptor (KOR) agonists are a promising alternative to currently available opioid drugs due to their low abuse potential. In the current study, we have investigated the effects of Salvinorin A (SalA) analogues, 16-Ethynyl SalA, 16-Bromo SalA and ethyoxymethyl ether (EOM) SalB, and in a preclinical model of paclitaxel-induced neuropathic pain in male and female C57BL/6J mice. Using an acute dose-response procedure, we showed that compared to morphine, 16-Ethynyl SalA was more potent at reducing mechanical allodynia; and SalA, 16-Ethynyl SalA, and …

When The Natural Toxin Concentration In Crotalaria Increase In Japan?, M. Kaneko, N. Kato, I. Hattori

IGC Proceedings (1977-2023)

A green manure crop, sunn hemp (Crotalaria juncea L.), legumes, has a nematode-suppressive effect. It is also used as feed in India. However, it is not used as feed in Japan because it contains natural toxins: Pyrrolizidine alkaloids (PAs). PAs has the negative effects for not only livestock but also human health. The PAs, which are abundant in sunn hemp seeds and which are contained only slightly in leaves and stems. Therefore, if sunn hemp harvested before flowering, then no poison problem is posed by PAs. However, if it is harvested at the podding stage, a poisonous concentration of …

Aapm Medical Physics Practice Guideline 12.A: Fluoroscopy Dose Management, Ryan F. Fisher, Kimberly E. Applegate, Lindsey K. Berkowitz, Olav Christianson, Jaydev K. Dave, Lindsay Deweese, Nichole Harris, Mary Ellen Jafari, A. Kyle Jones, Robert J. Kobistek, Brendan Loughran, Loren Marous, Donald L. Miller, Beth Schueler, Bryan C. Schwarz, Adam Springer, Kevin A. Wunderle

Radiology Faculty Publications

No abstract provided.