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Kentucky Water Resources Research Institute Annual Technical Report Fy 2003, Kentucky Water Resources Research Institute, University Of Kentucky

KWRRI Annual Technical Reports (USGS’s 104b Grant Program)

The FY2003 Annual Technical Report for Kentucky consolidates reporting requirements of the Section 104(b) base grant award in a single technical report that includes: 1) a synopsis of each research project supported during the period, 2) a list of related reports, 3) a description of information transfer activities, 4) a sumarry of student support during the reporting period, and 5) notable achievements and awards during the year.

Uk Law Notes, 2004, University Of Kentucky College Of Law

Annual Magazines

No abstract provided.

Public Tort Litigation: Public Benefit Or Public Nuisance?, Richard C. Ausness

Law Faculty Scholarly Articles

One of the latest developments in products liability law is "public tort" litigation. Public tort or government-sponsored lawsuits are actions by federal, state, or local government entities to recover the cost of public services provided to persons who have been injured as the result of a defendant's alleged misconduct. The best known example is the tobacco litigation of the mid-1990s in which more than forty states brought suit against the leading tobacco companies to recoup the cost of providing health care services to indigent smokers. Eventually, the tobacco companies agreed to pay the states more than $200 billion and also …

A Gc-Ms Method For The Determination Of Isoxsuprine In Biological Fluids Of The Horse Utilizing Electron Impact Ionization, Jeffrey M Bosken, A. F. Lehner, C. G. Hughes, W. E. Woods, F. C. Camargo, J. D. Harkins, J. Boyles, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Isoxsuprine is used to treat navicular disease and other lower-limb problems in the horse. Isoxsuprine is regulated as a class 4 compound by the Association of Racing Commissioners, International (ARCI) and, thus, requires regulatory monitoring. A gas chromatography-mass spectrometry method utilizing electron impact ionization was developed and validated for the quantitation of isoxsuprine in equine plasma or equine urine. The method utilized robotic solid-phase extraction and tri-methyl silyl ether products of derivatization. Products were bis-trimethylsilyl (TMS) isoxsuprine and tris-TMS ritodrine, which released intense quantifier ions m/z 178 for isoxsuprine and m/z 236 for ritodrine that were products of C-C cleavage. …

The Mare Reproductive Loss Syndrome And The Eastern Tent Caterpillar Ii: A Toxicokinetic/Clinical Evaluation And A Proposed Pathogenesis: Septic Penetrating Setae, Thomas Tobin, J. Daniel Harkins, John Ford Roberts, Patricia W. Vanmeter, Tara A. Fuller

Maxwell H. Gluck Equine Research Center Faculty Publications

Reviewing the mare reproductive loss syndrome (MRLS), it is proposed that the fundamental mechanism of this syndrome, which includes early fetal loss, late fetal loss, uveitis, pericarditis, and encephalitis, is tissue penetration by septic barbed setal fragments (septic penetrating setae) from Eastern tent caterpillars (Malacosoma americanum). Once ingested, these barbed setal fragments migrate through moving tissues, followed by rapid hematogenous spread of bacteria, bacterial emboli, and/or septic fragments of setae (septic penetrating setal emboli), collectively referred to as septic materials. Pathogenic bacteria, therefore, enter the horse as hitchhikers on or in the caterpillar setal fragments, and MRLS is caused by …

Proof Of Product Defect, David G. Owen

Kentucky Law Journal

No abstract provided.

A Climate Ripe For Abuse: The Role Of Kentucky's Workers' Compensation Law In Perpetuating Drug Abuse In The Appalachian Region, Stacy E. Miller

Kentucky Law Journal

No abstract provided.

Lending A Helping Hand?: A Guide To Kentucky's New Predatory Lending Law, Kent H. Barnett

Kentucky Law Journal

No abstract provided.

Co-Regulation Of Expression Of Phase Ii Metabolizing Enzymes And Multidrug Resistance-Associated Protein 2, Viviana A. Catania, Enrique J. Sánchez Pozzi, Marcelo G. Luquita, María L. Ruiz, Silvina S. M. Villanueva, Brett Jones, Aldo D. Mottino

Toxicology and Cancer Biology Faculty Publications

Treatment of experimental animals with prototypical enzyme inducers represents a useful tool to characterize the role of different isozymes in drug metabolism and to improve our knowledge on factors regulating their synthesis at the transcriptional level. The effect of model enzyme inducers on phase II (conjugating) enzyme families, including UDP-glucuronosyltransferase’s and glutathione-S-transferase’s, has been well characterized in rodent liver. More recently, the effect of inducers on the expression of canalicular multidrug resistance-associated protein 2 (Mrp2) has been focused upon. The identification of a number of conjugated drugs as Mrp2 substrates suggests that both the conjugation and transport systems act coordinately …

Early Adolescent Through Young Adult Alcohol And Marijuana Use Trajectories: Early Predictors, Young Adult Outcomes, And Predictive Utility, Kate Flory, Donald Lynam, Richard Milich, Carl Leukefeld, Richard Clayton

Psychology Faculty Publications

The present study takes a developmental approach to subgrouping and examines the trajectories of substance use from early adolescence through young adulthood among a community sample of 481 individuals. The patterns of use were examined, subgroups were identified separately for men and women and for alcohol and marijuana, and psychosocial predictors and psychopathology outcomes that differentiated the groups were identified. The results revealed three substantially overlapping subgroups for both alcohol and marijuana: early onset, late onset, and nonuser. Although the general patterns of which dependent variables were related to group were similar for alcohol and marijuana, a closer examination revealed …

Be Not Afraid Of Change: Time To Eliminate The Corporate Practice Of Medicine Doctrine, Nicole Huberfeld

Law Faculty Scholarly Articles

This article focuses on three key reasons that the corporate practice of medicine doctrine should be laid to rest. First, the motives for creating the corporate practice of medicine doctrine are long gone; it has been some time since physicians have been able to operate as a guild of autonomous providers of health care. The delivery and financing of health care places physicians in an integrated system that is only frustrated by the corporate practice of medicine doctrine. Second, it is disingenuous to pretend that physicians are not influenced by financial gain. This is handily evidenced by the federal and …

Race And Equality Across The Law School Curriculum: The Law Of Tax Exemption, David A. Brennen

Law Faculty Scholarly Articles

What is the relevance of race to tax law? The race issues are apparent when one studies a subject like constitutional law. The Constitution concerns itself explicitly with such matters as defining rights of citizenship, allocating powers of government, and determining rights with respect to property. Given the history of our country -- with slavery followed by periods of de jure and de facto racial discrimination -- these constitutional law matters obviously must have racial dimensions.

Tax law, however, does not generally concern itself explicitly with matters of race. Tax law is often thought of as completely race neutral in …

On Preemption, Congressional Intent, And Conflict Of Laws, Mary J. Davis

Law Faculty Scholarly Articles

Conflicts scholars and jurists for centuries have sought an answer to the question of "what law controls?" by balancing a number of considerations. Chief among those considerations are the legitimate political and policy concerns of conflicting sovereigns. This article analyzes the Supreme Court's recent preemption decisions with an understanding of these theories and their underlying considerations. That analysis reveals that the Court's recent preemption decisions incorporate two modem conflict of laws theories: Governmental Interest Analysis and its corollary, Comparative Impairment. Each of these theories builds on the notion that a choice of law analysis should be motivated by selecting the …

A Quarter Century, Not A Raised Voice, Robert G. Lawson, Rutheford B. Campbell Jr., Christopher W. Frost

Law Faculty Scholarly Articles

A tribute to Professor Willburt “Burt” D. Ham.

Preemption Of State Tort Law By Federal Safety Statutes: Supreme Court Preemption Jurisprudence Since Cipollone, Richard C. Ausness

Law Faculty Scholarly Articles

This article shall attempt to trace the twists and turns of Supreme Court preemption jurisprudence. Part I provides a brief overview of federal preemption law, considering the constitutional sources of preemption and the traditional preemption categories. Part II analyzes Cipollone v. Liggett Group, Inc., the source of modem Supreme Court doctrine regarding preemption of state tort law by federal safety legislation. Part III reviews seven post-Cipollone Supreme Court preemption cases: CSX Transportation, Inc. v. Easterwood, Freightliner Corp. v. Myrick, Medtronic, Inc. v. Lohr, Norfolk Southern Railway Co. v. Shanklin, Geier v. American Honda Motor …

Loss Of Sympathetic Control Of Cardiovascular Function Following Spinal Cord Injury, Charles Everett Hogancamp Ii

University of Kentucky Master's Theses

Cardiovascular control in the human is significantly impaired after spinal cord injury(SCI) having a direct effect on the sympathetic nervous system (SNS) causing an inability toregulate vasoconstriction below the level of the lesion. The effects of SCI on the two majorcomponents of blood pressure regulation, control of plasma volume and neural control of theheart and peripheral vasculature are poorly understood. In particular, no index to diagnosedisorders to autonomic control of the heart and vasculature has been developed. The presentstudy primarily utilized noninvasively acquired, easily accessible variables that may havepromise as indicators of autonomic activity for assessing the level of autonomic …

An Econometric Analysis Of Infant Mortality, Pollution, And Income In The U.S. Counties, Margarita Yuri Somov

University of Kentucky Master's Theses

The concept of economic development has broadened to include environmental quality and population health. Interactions between income and pollution, income and health, and pollution and health have been studied separately by researchers from various disciplines. This study attempts to unify several different research strands and analyze simultaneous interactions between population health, measured by the infant mortality rate, pollution, and income in one endogenous system. Socioeconomic, racial, and rural urban disparities in infant mortality, pollution, and income are analyzed. The simultaneous equation system, estimated using the two-stage least squares method, tests whether pollution effects on infant mortality are outweighed by income …

Contracting With Nonprofit Organizations: A Model For Local Governments, Renee Jackson

MPA/MPP/MPFM Capstone Projects

A number of factors have contributed to the rise in nonprofit organizations during the last three decades. No matter the reasons one significant consequence has been an intensification of competition for available funding. With the increasing competition for funding there is growing concern that there may not be an equitable and efficient method in place for many funders to base their allocation decisions on. These concerns arise from the issues that occur during funding processes such as: how open and competitive is the request for proposal process; is there duplication of the same service; can the organization adequately provide the …

An Investigation Of Image Processing Techniques For Paint Defect Detection Using A Machine Vision System, Ashish V. Kamat

University of Kentucky Master's Theses

Detection and inspection of metal surface corrosion in the ballast tanks of U.S. Navy ships has been a long time problem. The adverse climatic conditions to which the ballast tanks are exposed and the uneven geometry of ballast tanks makes the visual inspection process of surface coatings a difficult job. Thousands of tanks are inspected yearly, with the average cost of an individual tank inspection at approximately $8-15 thousand/each. To aid the visual inspection process, this research is conducted to develop a new technique to automate the visual task of metal surface inspection by image acquisition and post processing. The …

When The Safety Net Fails: An Analysis Of Alternative Long-Term Care Services In Kentucky, Suzanne Dale

MPA/MPP/MPFM Capstone Projects

The Problem

In early 2003, the Kentucky Cabinet for Health Services, faced with a $450 million Medicaid shortfall, implemented several cost-cutting measures to the Medicaid program. The most visible measure included new stricter medical eligibility requirements for long-term care programs. As a result of these new requirements, approximately 2,813 elderly and disabled Kentuckians were denied services in Kentucky’s Aged/Disabled Home and Community-Based Waiver Program, a Medicaid program that provides long-term care services in people’s homes and in community-settings. The Cabinet for Health Services claimed that those who lost home and community-based Medicaid services could receive care through alternative state programs. …

"Bonded & Insured?": The Future Of Mandatory Insurance Coverage And Disclosure Rules For Kentucky Attorneys, Nicholas A. Marsh

Kentucky Law Journal

No abstract provided.

Preemption Of State Tort Law By Federal Safety Statutes: Supreme Court Preemption Jurisprudence Since Cipollone, Richard C. Ausness

Kentucky Law Journal

No abstract provided.

Of Money And Judicial Independence: Can Inherent Powers Protect State Courts In Tough Fiscal Times?, Michael L. Buenger

Kentucky Law Journal

No abstract provided.

Organizational Economics And The Food Processing Industry, Benjamin M. Tirrell

University of Kentucky Master's Theses

The food processing industry is dominated by large corporations. These firms play a critical role in forming the derived demand faced by agricultural producers, but little is understood about how these companies make strategic choices. Organizational economics provides a framework for exploring the firm's decision process. However, several theories exist in this discipline, operating in fundamentally different ways. This paper examines the two prevalent organizational theories, Transaction Cost Economics and Agency Theory, through a study of the food processing industry. This sector is thoroughly analyzed in order to make predictions from each theory regarding the aspects of capital structure and …

Developing A Pediatric Oral Health Therapist To Help Address Oral Health Disparities Among Children, David A. Nash

Oral Health Science Faculty Publications

Oral Health in America: A Report of the Surgeon General documented the profound and significant disparities that exist in the oral health of children in the United States. Recently, the country has been issued a National Call to Action to Promote Oral Health, under the leadership of the Office of the Surgeon General. Among the significant factors contributing to the disparities problem is the access to oral health care by disadvantaged populations. There are inadequate numbers of dentists able and willing to treat children, particularly poor and minority children. In the early part of the twentieth century, New Zealand …

Surface Electromyography Characterization Of The Local Twitch Response Elected By Trigger Point Injection And Snapping Palpation In Myofascial Pain Patients, Pei Feng Lim

University of Kentucky Master's Theses

Local twitch responses (LTRs) can be elicited by snapping palpation of myofascial trigger points (TrP) or TrP injections. Objective: To characterize the LTR elicited by TrP injection and snapping palpation on surface electromyography (sEMG) in subjects with myofascial pain in 14 female subjects. Methods: Surface EMG electrodes were placed around the TrP and a control site on the trapezius muscle. Then the following protocol was carried out: tension and contraction of the ipsilateral trapezius muscle, baseline resting activity (five minutes), snapping palpation of the TrP and the control sites, TrP injection, and final resting activity (five minutes). The following data …

Nutrient Mediated Protection Against Endothelial Cell Dysfunction, Gudrun Reiterer

University of Kentucky Doctoral Dissertations

Atherosclerosis is thought to be initiated by endothelial cell dysfunction. Research described in this dissertation is focused on interactions of nutrients, cytokines and pharmaceutical compounds in the intracellular signaling pathways leading to endothelial cell activation. The flavonoid quercetin could significantly downregulate the inflammatory pathways induced by linoleic acid as determined by DNA binding assays of the proinflammatory transcription factors nuclear factor-kappaB and activator protein-1 as well as by gene expression studies of interleukin-6 and vascular adhesion molecule-1. Interestingly, quercetin and vitamin E also prevented the linoleic acid-induced activation of PPAR DNA binding - suggesting a role of oxidation in the …

Leptin Receptors In Caveolae: Regulation Of Lipolysis In 3t3-L1 Adipocytes, Gentle P. Chikani

University of Kentucky Master's Theses

The present study has tested the hypothesis that leptin receptors are localized in caveolae and that caveolae are involved in the leptin-induced stimulation of lipolysis in 3T3-L1 adipocytes. Leptin, a peptide hormone, is secreted primarily by adipocytes and has been postulated to regulate food intake and energy expenditure via hypothalamic-mediated effects. Exposure to leptin increases the lipolytic activity in 3T3-L1 adipocytes. We isolated caveolae from 3T3-L1 adipocytes using a detergent free sucrose gradient centrifugation method. Leptin receptors were localized in the same gradient fraction as caveolin-1. Confocal microscopic studies demonstrated the colocalization of leptin receptors with caveolin-1 in the plasma …

Identification Of Signaling Factors Involved In The Regulation Of Alkaloid Metabolism In N. Tabacum, Nita Sachan

University of Kentucky Doctoral Dissertations

To identify the signaling mechanisms and components that are involved in regulation of a promoter for a gene involved in a secondary pathway I studied the nicotinic alkaloid biosynthetic pathway using various N. tabacum tissues. Nicotine and tropane alkaloids are widely known to be synthesized predominantly in the roots of species that produce pyrrolinium ring containing alkaloids. Putrescine Nmethyltransferase (PMT) catalyzes the first committed step in the biosynthesis of these alkaloid secondary products and earlier studies have indicated that PMT gene expression is restricted to root tissue in Solanaceae plants. To further elucidate the factors that govern the regulation of …

Thymoquinone: The Evaluation Of Its Cytotoxic Potential, Effects On P53 Status And The Cell Cycle In Various Cancer Cell Lines, Alison Ann Mokashi

University of Kentucky Master's Theses

Cancer is a group of diseases that are the second leading cause of human mortality in the United States. Discovering new therapies is vital to conquer cancer. Thymoquinone (TQ) is found in the plant Nigella sativa. TQ was found to be cytotoxic to the human ovarian cancer cell lines PA-1, CAOV-3 and SKOV-3, which have varying p53 status. PA-1 cells were the most sensitive, indicating that TQ was effective against cells having wild-type (WT) p53. Western blots indicated an increase in p53 in cell lines having WT p53. TQ when given concurrently with cisplatin resulted in antagonism for PA-1, A172 …