Digital Commons Network^™

2,6-Disubstituted Piperidines As Modulators Of Nicotinic Acetylcholine Receptor Mediated Neurotransmitter Release, Uptake And Storage, Peter A. Crooks, Linda P. Dwoskin, Dennis Keith Miller, Vladimir P. Grinevich, Seth Davin Norrholm, Guangrong Zheng

Pharmaceutical Sciences Faculty Patents

Compounds used for treating dependence on or withdrawal from a drug of abuse, for an eating disorder or for a CNS disease or pathology . . .

To see the remainder of this abstract, please download this patent.

Carbon Fiber For Air Filtration, Marit Jagtoyen, Francis J. Derbyshire, Rosemary Anne Alexander Derbyshire

Center for Applied Energy Research Faculty Patents

Described are filters containing free-activated carbon fibers or activated carbon fibers in the form of a composite used for filtering a variety of contaminants, including pathogens, from air. These filters can provide effective and efficient removal of contaminants from air, requiring only short contact time between the air being filtered and the filter itself, with only a minimum pressure drop across the filter. The characteristics of these filters allow for effective filtration with only thin filter layers being required. The process of filtering air utilizing these filters is also disclosed.

Construction Laborer Dies From Heat Stroke At End Of Workday, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Other

On June 27, 2003, a 41-year-old, male laborer died from heat stroke one day after being taken to the hospital. The laborer was working on an addition to a factory sawing boards to make concrete forms. He worked until 5:00 pm that day and was in the parking lot on his way to his vehicle when he apparently collapsed beside his vehicle. A worker on the second shift at the factory was taking scrap material outside to a dumpster when he found the laborer on the ground. The factory worker returned to the plant and told his supervisor there was …

Highway Construction Worker Dies When Struck By Semi-Tractor Trailer, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Motor Vehicle

At approximately 8:30 am on April 16, 2003, a 48-year-old male (decedent) highway construction laborer working in an interstate highway median, died when he was struck by an out-of-control double trailer (a semi-truck pulling two trailers). The laborer was speaking with the job foreman and another laborer in the median next to a grading machine. As the decedent looked toward the traffic, he saw a double trailer traveling on the right-hand shoulder swerve into the left-hand lane and drive into the median where all three men were standing. He told the other two to get out of the way as …

28-Year-Old Man Dies After Falling With Lift, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Falls

On June 27, 2003, a 28-year-old male sound technician died due to injuries received after falling approximately 50 feet from a lift. Three men (one chief sound engineer and two sound technicians) were sent to repair a sound system in a school gymnasium. Upon arriving and assessing the situation, the three diagnosed that a particular speaker, located in the rafters, should be removed from its location. Using a 30-year-old telescoping, self-leveling lift belonging to the school, the chief engineer used controls located at the base of the lift, to hoist the two sound technicians to the speaker in the rafter. …

Forage News [2004-03], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• UK Forage Extension Website
• Alfalfa Award Winners
• Heart of America Grazing Conference
• Native Grasses
• Broomsedge in Pastures
• How Can Quality Analyses Be Different Between Labs?
• Extending the Grazing Season with Corn
• AFGC in Virginia
• Upcoming Events

Fatal Tractor Overturns: Don't Let Them Roll Over You!, Kentucky Injury Prevention And Research Center

Kentucky Haz Alerts--Tractors/Logging

To prevent tractor injuries:

• All tractors should be equipped with a Roll Over Protective Structure (ROPS) and a seat belt.
• Tractors should be equipped with front-end counterweights and tractor wheels
• should be weighted to increase stability.
• Community farm safety training with safe operating procedures and hazard identification should be offered to novice or limited- experience operators.

Moisture--Temperature Management During Alfalfa Hay And Silage Making & Storing, Michael Collins

Kentucky Alfalfa and Stored Forage Conference

In some areas of the country, producers store a substantial portion of their forage for winter feeding as silage or haylage. However, hay remains the most popular storage method for forage. Hay stores well for long periods and is better suited to cash sale and transportation than silage. Mechanical conditioning, which gained acceptance during the 1950's is probably still the greatest single change in hay harvesting and storage technology during this century. However, a number of other noteworthy changes and innovations have occurred in recent years which have helped to reduce the extent of losses during hay harvesting and storage.

Grazing Alfalfa, Garry D. Lacefield

Kentucky Alfalfa and Stored Forage Conference

Over the past decade we have had several people address “Alfalfa as a Grazing Crop” including Warren Thompson, Gary Bates, Ken Johnson, Jason Sandefur, Byron Sleugh, and myself. Each has done an excellent job discussing the merits of this remarkable crop and the opportunities it offers for grazing. At the end of the Conference last year, I (as I always do) asked for your suggestions concerning topics for this years’ conference. As it has been for the past decade, “Grazing” was the most requested topic. In today’s presentation, let’s go back and revisit the question, “Is Grazing Alfalfa Right for …

Forage News [2004-02], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• 24^TH Kentucky Alfalfa Conference
• Forages at KCA Proceedings Available On-Line
• Forage Variety Information Available
• Spring Grazing School
• Improving Forage Systems is Focus of Northeast Kentucky Program
• What is Quality Worth?
• KFGC Election Results
• Bermudagrass Update
• Upcoming Events

Using Covers To Minimize Odor And Gas Emissions From Manure Storages, José R. Bicudo, David R. Schmidt, Larry D. Jacobson

Agricultural Engineering Extension Publications

Odor emissions from animal production sites are typically the leading cause of nuisance complaints. Locating facilities far from neighbors is often a solution to the odor problem, but this is not always an option for producers. Most often, reducing odor emissions from the farm is the only option available.

Rural Kentucky’S Physician Shortage: Strategies For Producing, Recruiting And Retaining Primary Care Providers Within A Medically Underserved Region, Baretta R. Casey, Judy Jones, David A. Gross, Lola Dixon

Center of Excellence in Rural Health Reports

Examines the inadequate supply of doctors in outlying regions of the Commonwealth. Through literature review, data analysis, personal interviews and other research methods, the UK Center for Excellence in Rural Health-Hazard study concluded that Kentucky needs an additional 600 primary care physicians in order to adequately meet the health care needs of its residents. The findings appear in the October 2005 Journal of the Kentucky Medical Association.

Nucleic Acid Encoding Human Rev1 Protein, Zhigang Wang, Winston Lin, Hua Xin, Xiaohua Wu

Toxicology and Cancer Biology Faculty Patents

The present invention relates to a human cDNA homologous to the yeast REV1 gene. The sequence of human REV1 (hREV1) gene is described.

Topical Formulations For The Transdermal Delivery Of Niacin And Methods Of Treating Hyperlipidemia, Elaine L. Jacobson, Myron Jacobson, Hyuntae Kim, Moonsun Kim, Jaber G. Qasem

Graduate Center for Nutritional Sciences Faculty Patents

Niacin and niacin prodrugs are topically administered as suitable formulations to device for impoving the lipid profiles of subjects, preferably humans.

Southeastern Law Librarian Winter 2004, Seaall

Newsletters

No abstract provided.

Prospects Of Agricultural Entrepreneurship Among Resource Limited Farmers In The Central Appalachian Tobacco Belt, M’Kiaira Kimathi Miriti, Eric Scorsone

University of Kentucky Center for Poverty Research Discussion Paper Series

Agricultural entrepreneurship is receiving heightened attention as a potential means for economic revitalization of communities adversely affected by changes in the agricultural sector. In particular, resource limited farmers in the Appalachian region of the United States have been hit by major changes in the tobacco industry. Very little is known about resource limited farmers respond to changing industry conditions and policy attempts to remedy structural change. Recently, the Commonwealth of Kentucky has attempted to assist farmers in adopting new farmbased enterprises to expand their income base. However, it is unclear about the factors that drive entrepreneurial or diversification activities among …

Tribute To Willburt D. Ham, Robert G. Lawson, Rutheford B. Campbell Jr., Christopher W. Frost

Kentucky Law Journal

No abstract provided.

Horizontal Stare Decisis On The U.S. Court Of Appeals For The Sixth Circuit, Emery G. Lee Iii

Kentucky Law Journal

No abstract provided.

No Pain No Gain?! Who Will Make The Greatest Sacrifices In Curbing Opioid Analgesic Diversion And Abuse?, Kent Durning

Kentucky Law Journal

No abstract provided.

The Ramifications Of Rejecting Wrongful Birth: A Closer Look At Grubbs V. Barbourville Family Health Center, Johanna L. Frantz

Kentucky Law Journal

No abstract provided.

Reflections On Undergraduate Research Mentoring, Robert L. Houtz

Kaleidoscope

No abstract provided.

Trends And Comparisons In Higher Education Economics: How Has Kentucky Fared?, William Hoyt

CBER Research Report

No abstract provided.

Lessons From The French Funding Debate, Kathryn L. Moore

Law Faculty Scholarly Articles

The French retirement system, like the American social security system, is facing long-term funding difficulties. As a result, the French are debating whether to expand the role of pre-funded retirement plans. The economic arguments presented in this debate are virtually identical to the economic arguments presented in the American debate on whether the American social security system should be partially privatized.

The French and American debates, however, diverge once history and ideology are considered. The French have a history of failed funded pensions in contrast to the United States where the failure of prominent underfunded pension led to the enactment …

Kentucky Annual Economic Report 2004, Eric C. Thompson, Glenn C. Blomquist, Devanathan Sudharshan, Roy A. Sigafus

Kentucky Annual Economic Report

No abstract provided.

Manganese Toxicokinetics At The Blood-Brain Barrier, Robert A. Yokel, Janelle S. Crossgrove

Pharmaceutical Sciences Reports

Increased manganese (Mn) use in manufacturing and in gasoline has raised concern about Mn-induced parkinsonism. Previous research indicated carrier-mediated brain entry but did not assess brain efflux.

Using in situ rat brain perfusion, we studied influx across the blood-brain barrier (BBB) of three predominant plasma Mn species available to enter the brain: Mn²⁺, Mn citrate, and Mn transferrin. Our results suggested transporter-mediated uptake of these species. The uptake rate was greatest for Mn citrate. Our results using the brain efflux index method suggested that diffusion mediates distribution from rat brain to blood.

To characterize the carriers mediating brain …

Detection And Confirmation Of Ractopamine And Its Metabolites In Horse Urine After Paylean® Administration, A. F. Lehner, C. G. Hughes, J Daniel Harkins, C. Nickerson, B. Mollett, L. Dirikolu, Jeffrey M Bosken, Fernanda C. Camargo, J. Boyles, A. Troppmann, W. Karpiesiuk, W. E. Woods, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

We have investigated the detection, confirmation, and metabolism of the beta-adrenergic agonist ractopamine administered as Paylean to the horse. A Testing Components Corporation enzyme-linked imunosorbent assay (ELISA) kit for ractopamine displayed linear response between 1.0 and 100 ng/ml, with an 1-50 of 10 ng/ml, and an effective screening limit of detection of 50 ng/mL. The kit was readily able to detect ractopamine equivalents in unhydrolyzed urine up to 24 h following a 300-mg oral dose. Gas chromatography-mass spectrometry (GC-MS) confirmation comprised glucuronidase treatment, solid-phase extraction, and trimethylsilyl derivatization, with selected-ion monitoring of ractopamine-tris(trimethylsilane) (TMS) m/z 267, 250, 179, and 502 …

Development Of A Method For The Detection And Confirmation Of The Alpha-2 Agonist Amitraz And Its Major Metabolite In Horse Urine, A. F. Lehner, C. G. Hughes, W. Karpiesiuk, J Daniel Harkins, L. Dirikolu, Jeffrey M Bosken, Fernanda Camargo, J. Boyles, A. Troppmann, W. E. Woods, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Amitraz (N′-(2,4-dimethylphenyl)-N-[[(2,4-dimethylphenyl)imino] methyl]-N-methyl-methanimidamide) is an alpha-2 adrenergic agonist used in veterinary medicine primarily as a scabicide- or acaricide-type insecticide. As an alpha-2 adrenergic agonist, it also has sedative/tranquilizing properties and is, therefore, listed as an Association of Racing Commissioners International Class 3 Foreign Substance, indicating its potential to influence the outcome of horse races. We identified the principal equine metabolite of amitraz as N-2,4-dimethylphenyl-N′-methylformamidine by electrospray ionization(+)-mass spectrometry and developed a gas chromatographic-mass spectrometric (GC-MS) method for its detection, quantitation, and confirmation in performance horse regulation. The GC-MS method involves derivatization with t-butyldimethylsilyl groups; selected ion monitoring (SIM) of m/z …

The Law's Hard Choice: Self-Inflicted Injustice Or Lawyer-Inflicted Indignity, Christopher Johnson

Kentucky Law Journal

No abstract provided.

Reflections: Fifty Years After Brown V. Board Of Education, Janet Reno

Kentucky Law Journal

No abstract provided.

Inherent Product Hazards, David G. Owen

Kentucky Law Journal

No abstract provided.