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Denervation Supersensitivity Of Βeta-Adrenergic Receptors In A Prodromal Model Of Alzheimer's Disease, The Tgf344-Ad Rat, Anthoni Goodman Jan 2020

Denervation Supersensitivity Of Βeta-Adrenergic Receptors In A Prodromal Model Of Alzheimer's Disease, The Tgf344-Ad Rat, Anthoni Goodman

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The central noradrenergic (NA) system is critical for maintenance of attention, behavioral flexibility, spatial navigation, and learning and memory, those cognitive functions lost first in early Alzheimer’s disease (AD). In fact, the locus coeruleus (LC), the major source of norepinephrine (NE) in brain, is the first site of pathological tau accumulation in human AD associated with axon loss throughout forebrain, including hippocampus. The dentate gyrus (DG) is heavily innervated by LC-NA axons, where released norepinephrine (NE) acts on β adrenergic receptors (ARs) at excitatory synapses from entorhinal cortex (EC) to facilitate long-term synaptic plasticity and memory formation. These synapses show …

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Microrna Regulation Of Post-Injury Cardiac Remodeling And Heart Failure, John Clark Henderson Jan 2020

Microrna Regulation Of Post-Injury Cardiac Remodeling And Heart Failure, John Clark Henderson

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Doxorubicin (DOX), an anthracycline, is a widely used chemotherapy agent against various forms of cancer; however, it is also known to induce dose-dependent cardiotoxicity leading to adverse outcomes. Investigating the underlying molecular signaling might have clinical implications. MicroRNAs (miRNAs) have been shown to mediate many diseases and are used as biomarkers for chemotherapy; but currently their role in the regulation of DOX-induced cardiotoxicity is not well understood. Our previous study has shown upregulation of miRNA-377 in the cardiomyocytes (CMs) after cardiac ischemia-reperfusion injury in mice. In this dissertation, we discovered that miR-377 was upregulated in the myocardium after DOX treatment, …

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Il-17 Producing Cd4 T Cells In Spontaneous Germinal Center And Autoantibody Formation In Murine Lupus, Huixian Hong Jan 2020

Il-17 Producing Cd4 T Cells In Spontaneous Germinal Center And Autoantibody Formation In Murine Lupus, Huixian Hong

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IL-23 promotes autoimmune disease, including Th17 CD4 T-cell development and autoantibody (autoAb) production. Here, we show that a deficiency of the p19 component of IL-23 in the autoimmune BXD2 (BXD2-p19−/−) mouse leads to a shift of the follicular T-helper cell program from Tfh-IL-17 to Tfh-IFN-ɣ. Although the germinal center (GC) size and the number of GC B cells remained the same, BXD2-p19−/− mice exhibited a lower class-switch recombination (CSR) in the GC B cells, leading to lower serum levels of IgG2b. Single-cell transcriptomics analysis of GC B cells revealed that while Ifngr1, Il21r and Il4r genes exhibited a synchronized expression …

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Examining The Role Of Neighborhood Quality On The Association Of Mammography Adherence Among Racial/Ethnic Groups, Roman Johnson Jan 2020

Examining The Role Of Neighborhood Quality On The Association Of Mammography Adherence Among Racial/Ethnic Groups, Roman Johnson

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Although several racial/ethnic minority women groups (e.g., Latina, Black, Asian-American, and Native-American women) have lower breast cancer incidence than white women, they are more likely to die from breast cancer. One possible explanation for this discrepancy is racial/ethnic differences in mammography use. Mammography has been shown to contribute to the discovery of tumor proliferation earlier which translates to less breast cancer complications like greater risk of breast cancer-related mortality. Previous studies on racial/ethnic differences in mammography adherence (e.g., annual and biannual mammography adherence) have been inconclusive, and they generally overlook important contextual factors, namely neighborhood quality and geographic location (e.g., …

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Is Ambition Consequential? Exploring The Association Between Depressive Symptomatology And The Educational Expectation Trajectories And Achievements Of Immigrant Youth, Fabrice Stanley Julien Jan 2020

Is Ambition Consequential? Exploring The Association Between Depressive Symptomatology And The Educational Expectation Trajectories And Achievements Of Immigrant Youth, Fabrice Stanley Julien

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Concerning mental health outcomes, immigrant youth are a particularly vulnerable population. The lack of health care access contributes to aggrandized and unmet mental health needs. This research explores how the social positions of immigrant families influence stress exposure and contribute to a worsening of well-being. Past research points to the societal stressors experienced by these young people, as significant predictors of their well-being. But what occurs when the source of stress originates within the home? Specifically, this study examines how stress, educational expectations and academic achievement influence the depressive symptomatology of immigrant youth. Education is a widely recognized predictor of …

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Pharmacodynamic Responses And Efficacies Associated With Lrrk2 Inhibition, Kaela Kelly Jan 2020

Pharmacodynamic Responses And Efficacies Associated With Lrrk2 Inhibition, Kaela Kelly

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Parkinson’s disease (PD) is an age-related, progressive, movement disorder pathologically characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and the presence of proteinaceous aggregates, termed Lewy bodies, that are largely comprised of αSynuclein (αSyn). Missense mutations in the leucine-rich repeat kinase (LRRK2) gene are the most common genetic cause of PD and lead to gain-of-function increases in kinase activity. The G2019S-LRRK2 mutation is the most frequent mutation and elevates kinase activity by ~2-3 fold. Genetic and biochemical evidence suggest elevated LRRK2 kinase activity plays a pathogenic role in the development of PD, implicating LRRK2 …

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Planning Of Detours For Major Construction Projects And Assessing Their Impacts On Traffic Operations, Md Saiful Arif Khan Jan 2020

Planning Of Detours For Major Construction Projects And Assessing Their Impacts On Traffic Operations, Md Saiful Arif Khan

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Maintenance and Rehabilitation (M&R) works are prevalent in the US highways to preserve an acceptable level of service. In the presence of construction works, detour planning around work zones is often compulsory to carry out the repair works properly and safely while also accommodating the needs of the traveling public. Hence, it becomes important for transportation agencies to develop and implement detour plans that provide diversion options to the road users that minimize their inconvenience and travel delays in the presence of construction works. Thus, evaluating the impact of detouring due to road closure is crucial to corroborate an effective …

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The Effect Of Gi Patients' Health Literacy Levels On Gi Patients' Health Outcomes, Dae Hyun Kim Jan 2020

The Effect Of Gi Patients' Health Literacy Levels On Gi Patients' Health Outcomes, Dae Hyun Kim

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The paper in this dissertation provide empirical evidence on the effect of GI patients’ health literacy levels on GI patients’ health outcomes. The findings of this study contribute to existing body of literature on health literacy and health outcomes. Furthermore, the findings also offer both theoretical and practical implications to physicians, healthcare administrators, and policymakers. Overall, the results of this study show that GI patients’ health literacy levels are negatively associated with GI patients’ health outcomes (hospital length of stay, readmission, and complication). However, partial support was shown for different types of GI surgeries accentuating the negative association between GI …

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Incorporating Spatial Structure Into Bayesian Variable Selection Using Spike-And-Slab Priors With Application To Imaging Data, Justin Leach Jan 2020

Incorporating Spatial Structure Into Bayesian Variable Selection Using Spike-And-Slab Priors With Application To Imaging Data, Justin Leach

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Many applications in neuroscience, psychology, medicine, and public health require collecting and analyzing imaging data. While fine resolution images may appear continuous to the naked eye, they are in fact made up of measurements at discrete locations, either pixels in 2D or voxels in 3D. These data may be treated as the scientific outcomes of interest, or as predictors of outcomes of interest. Here, the concern is with the latter situation, which involves converting images into formats amenable to a linear modeling framework; i.e., each subject’s image is converted into a vector, and used to model the subject’s (scalar) outcome …

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A Preliminary Analysis On The Effects Of Acute Beetroot Juice Intake On Glycemic And Blood Pressure Control In Type 2 Diabetes, Braxton Linder Jan 2020

A Preliminary Analysis On The Effects Of Acute Beetroot Juice Intake On Glycemic And Blood Pressure Control In Type 2 Diabetes, Braxton Linder

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Cardiometabolic diseases are becoming increasingly prevalent in modern society due to low activity lifestyles and poor nutrition. Inorganic dietary nitrate (diNO3) has shown to potentially improve cardiometabolic health in a number of different populations but remains to be corroborated in humans with type 2 diabetes (T2D). This preliminary analysis aimed to determine the effects of consuming an acute, concentrated dose of diNO3 containing beetroot juice (BRJ) on hemodynamic and glycemic responses in humans with T2D while controlling for pharmacological influences. Three participants with a clinical diagnosis of T2D were recruited into this study. Pulsewave Velocity (PWV) was used to assess …

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The Retention Of Zirconia Crowns Luted With Resin And Rmgi Cements And The Effect Of Salivary Contamination, Stephen Liu Jan 2020

The Retention Of Zirconia Crowns Luted With Resin And Rmgi Cements And The Effect Of Salivary Contamination, Stephen Liu

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Purpose: To measure retention of zirconia crowns bonded with resin and RMGI cements and the effect of salivary contamination following 10,000 cycles of thermocycling. Materials and Methods: 64 extracted human mandibular premolars were divided into eight groups (n = 8/group). The specimens in each group were prepared for Katana HT zirconia (eight groups) and one of four luting cements (one for each group): 3M ESPE RelyX Luting Plus RMGI, 3M ESPE Rely X Unicem 2 self-adhesive, Kuraray Panavia SA Universal self-adhesive, and 3M ESPE RelyX Ultimate dual cure resin cement with Scotchbond Universal. The roots of the selected teeth were …

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Nonsyndromic Hypodontia Of Maxillary Lateral Incisors, Its Genetics And Its Association With Other Dental Anomalies, Giana Lupinetti Jan 2020

Nonsyndromic Hypodontia Of Maxillary Lateral Incisors, Its Genetics And Its Association With Other Dental Anomalies, Giana Lupinetti

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NONSYNDROMIC HYPODONTIA OF MAXILLARY LATERAL INCISORS, ITS GENETICS, AND ITS ASSOCIATION WITH OTHER DENTAL ANOMALIES GIANA LUPINETTIDEPARTMENT OF ORTHODONTICS ABSTRACT Congenital absence of maxillary lateral incisors presents a difficult situation for clini-cians for restorative and orthodontic purposes. Further, missing lateral incisor agenesis (MLIA) has been associated with other dental anomalies and cancer. 1 Few studies have targeted MLIA as a specific subtype of hypodontia. WNT10A is a candidate gene for MLIA. 2 The hypothesis was that genetic mutations in WNT10A affect maxillary lateral tooth development and can contribute to other dental anomalies. The first aim was to evaluate patients with …

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Protective Host Responses During Acute And Chronic Lung Exposure To Aspergillus Fumigatus, Joseph Mackel Jan 2020

Protective Host Responses During Acute And Chronic Lung Exposure To Aspergillus Fumigatus, Joseph Mackel

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Aspergillus fumigatus is an environmental airborne fungus that acts as both an opportunistic pathogen and an allergen. In immunocompromised hosts, A. fumigatus can germinate in the lung, cause tissue damage and pneumonia, and disseminate to other organs, causing a disease termed invasive aspergillosis (IA). In severe asthma, sensitization to fungi such as A. fumigatus is associated with more severe disease. Determination of host and fungal factors that drive immunoprotection versus immunopathogenesis in both of these settings will ultimately enable therapeutic modulation of immune responses to improve disease outcomes. In this body of work, we build on recent findings that implicate …

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Gp44, A Minor Protein With A Major Role In Bacteriophage 80Α Infection, Keith Allen Manning Jan 2020

Gp44, A Minor Protein With A Major Role In Bacteriophage 80Α Infection, Keith Allen Manning

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Bacteriophage 80α is a temperate double-stranded DNA phage that infects Staphylococcus aureus and is capable of mobilizing a variety of mobile genetic elements named S. aureus Pathogenicity Islands. The capsid of the mature virion is composed of subunits of the capsid protein, portal protein, and a minor capsid protein gp44 as well as packaged phage genomic DNA. The loss of the gp44 protein completely eliminates the phage titer of 80α but does not eliminate the transduction of the pathogenicity islands. In this dissertation, I show that the minor capsid protein is primarily active in a post-ejection role. Without gp44 the …

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Life-Space And Cognitive Function By Cardiovascular Disease Risk: A Cross-Sectional Analysis From The Regards Study, Emiri Matsuda Jan 2020

Life-Space And Cognitive Function By Cardiovascular Disease Risk: A Cross-Sectional Analysis From The Regards Study, Emiri Matsuda

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Performance on mobility assessments has been extensively linked to processing speed and executive function among older adults. However, less is known about the relationship between cognitive function and functional mobility as part of day to day life. African American individuals are at higher risk of cardiovascular complications, functional mobility, and cognitive decline compared to Whites. In addition, cardiovas-cular disease risk factors and neuropathology have been linked to impairment in several domains of cognitive function, including processing speed. The current study examined the cross-sectional association between life-space and cognitive function, specifically performance on the Digit Symbol Substitution Test (DSST), a measure …

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The Role Of The Β-Catenin Signaling Pathway In Modulating The Nucleolar Proteome Of Triple Negative Breast Cancer, Shannon E. Meier Jan 2020

The Role Of The Β-Catenin Signaling Pathway In Modulating The Nucleolar Proteome Of Triple Negative Breast Cancer, Shannon E. Meier

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Previously, abnormal nucleoli were noted as indicators of cancerous lesions andused as a pathologic readout of neoplasia. Nucleolar hypertrophy and increased nucleolar number have been correlated with increased breast cancer (BC) mortality rates. Although various functions of the nucleolus have been investigated, it remains widely understudied in the context of cancer. The nucleolus was initially thought to be solely the site of ribosome biogenesis. However, over half of the proteins found in the nucleolus are associated with other biological functions. It is evident that the nucleolus plays major roles in stress response, DNA repair, and critical cellular aspects that influence …

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Evaluation Of The Effectivenss Of Rotc Army Cadet Exercise Training For The Army Combat Fitness Test, Jake Mintz Jan 2020

Evaluation Of The Effectivenss Of Rotc Army Cadet Exercise Training For The Army Combat Fitness Test, Jake Mintz

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The purpose of the study is to evaluate the effectiveness of ROTC Army cadet exercise training for the Army Combat Fitness Test (ACFT). A secondary purpose was to evaluate the effectiveness and perception of a remote training program. The cadets performed an 8-week training program that consisted of similar movements to the movements seen on the ACFT. Following 8 weeks, the cadets retested the ACFT. Performance measures were in-creased in the scores and scoring variable of the 3-repetition deadlift and 2-mile run (p < .005). The overall testing score also improved significantly. These results imply that an 8-week training program focusing on movements similar to those tested by the ACFT could improve ACFT score.

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Advancing Single Cell And Crispr/Dcas9 Technologies For The Study Of Reward Learning And Addiction, Corey Grant Duke Jan 2020

Advancing Single Cell And Crispr/Dcas9 Technologies For The Study Of Reward Learning And Addiction, Corey Grant Duke

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Drug addiction is a chronic relapsing condition inflicting tremendous harm to individuals and society with ineffective treatment options available to most people. Drugs of abuse elevate dopamine levels in a brain region known as the nucleus accumbens (NAc), and activate gene programs considered essential for producing lasting synaptic and cell state changes which underlie the generation of addictive behavior. These gene expression changes remain poorly understood due to a complex heterogenous cellular architecture, and the rapidly fluctuating nature of the transcriptional processes themselves which make investigation difficult. Recent technical advances increase access to both profiling and manipulating these transcriptional changes …

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An Augmented Framework For Validating Neural Network Predictions Based On Statistical Modeling, William Stonewall Monroe Jan 2020

An Augmented Framework For Validating Neural Network Predictions Based On Statistical Modeling, William Stonewall Monroe

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The Parkinson's Progression Markers Initiative (PPMI) dataset (which includes several types of imaging datasets) was created to generate biomarkers for diagnosing the presence and severity of Parkinson’s Disease (PD). Unlike some conditions, PD is not intuitively diagnosed directly from brain imaging. As such, it is vital to understand as well as classify PD. Deep learning techniques are becoming increasingly prevalent in medical imaging workflows. In some cases, deep learning outperforms human diagnostic ability. However, the black-box nature of many machine learning models can be troubling, particularly in a medical context since the results could imply alternate treatments and a human …

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Modeling And Optimization Of Trigeneration System In Daycare Facility, Andres Morales Jan 2020

Modeling And Optimization Of Trigeneration System In Daycare Facility, Andres Morales

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Trigeneration systems, also known as Combined Cooling, Heating, and Power (CCHP), simultaneously provide electric, mechanical, and thermal energy. Compared to traditional systems, they deliver higher fuel efficiencies as waste heat from engine coolant and/or exhaust is recovered and utilized. In heating, ventilation, and air condi-tioning (HVAC) systems, the recycled heat may be used to provide space heating, water heating, and cooling (through absorption chillers). As there are more practical applica-tions for the recovered heat during the heating season than the cooling season, trigenera-tion systems tend to be more attractive in colder weather. This research focuses on the PowerAire 65 by …

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Deficiency Of Tumor Suppressor Merlin Induces Metabolic Reprogramming In Breast Cancer, Mateus Mota Jan 2020

Deficiency Of Tumor Suppressor Merlin Induces Metabolic Reprogramming In Breast Cancer, Mateus Mota

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The tumor suppressor Merlin is encoded by Neurofibromin 2 (NF2) gene. Merlin is predominantly located in the cell cortex where regulates cell proliferation by mediating cell contact-dependent growth inhibition. Metastatic breast cancer tissues presented with a remarkable loss of Merlin protein, revealing clinical relevance of Merlin. In order to examine the cellular effect of Merlin deficiency, breast cancer cell lines were silenced for NF2. Additionally, to assess the impact of Merlin loss at the organismal level, a mammary-specific NF2 knockout mouse mammary tumor model was engineered. Merlin deficiency induced a metabolic shift from mitochondrial oxidative phosphorylation to aerobic glycolysis. Furthermore, …

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Downstream Pathways Of Glucagon Receptor Agonism In Obesity, Shelly Nason Jan 2020

Downstream Pathways Of Glucagon Receptor Agonism In Obesity, Shelly Nason

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Obesity is highly prevalent and strategies to improve weight loss maintenance are critical for healthcare. Behavioral interventions are effective but require major lifestyle changes that are often difficult to maintain long-term. Therefore, modifying energy balance with pharmacotherapy is a strategy to combine with lifestyle modifications for sustained weight loss. Glucagon, a hormone involved in maintaining glucose homeostasis, also regulates energy expenditure, food intake, and lipid metabolism. As such, glucagon-based therapies have gained attention as an attractive clinical target. Glucagon Receptor (GCGR) mono-agonism induces glucose intolerance; therefore, dissecting the mechanisms by which GCGR signaling mediates energy balance are clinically relevant to …

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Mendicant Enterprise And Human Rights In New Spain, Elliot Nicholson-Cox Jan 2020

Mendicant Enterprise And Human Rights In New Spain, Elliot Nicholson-Cox

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In 1521, the destruction of Aztec leadership created a disjointed network of native communities in what is now Mexico but would come to be known as New Spain. Until 1572 New Spain was an open and contested space for political, economic, and religious dominance among various Spanish factions. This dominance was predicated upon an evangelical mission in service to the conversion of native people from “pagans” to Christians. Religious education and evangelization by mendicant friars may have, either as a deliberate or consequential outcome, promoted or enforced collaboration and minimized direct and violent conflict during this period. Some religious friars …

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Protective Effects Of Thioredoxin Reductase Inhibition In The Murine Lung: The Regulation And Contribution Of Heme Oxygenase-1, Katelyn Louise Dunigan-Russell Jan 2020

Protective Effects Of Thioredoxin Reductase Inhibition In The Murine Lung: The Regulation And Contribution Of Heme Oxygenase-1, Katelyn Louise Dunigan-Russell

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Endogenous antioxidant responses defend the lung against oxygen toxicity. In premature neonates, oxygen toxicity and impaired antioxidant defenses contribute to the development of bronchopulmonary dysplasia (BPD), the leading cause of long-term morbidity among premature infants. In adults, oxygen toxicity and impaired antioxidant defense contributes to the pathogenesis of acute lung injury (ALI). Acute Respiratory Distress Syndrome (ARDS), a severe form of ALI, can cause permeant lung damage and mortality. Our lab has established that pharmacologic thioredoxin reductase-1 (TXNRD1) inhibition attenuates lung injury in murine BPD and ALI models. The protective effects of TXNRD1 inhibition are mediated by the activation of …

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Between Breaths, Kristin Entler Jan 2020

Between Breaths, Kristin Entler

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This collection evaluates, primarily, the nature of absence through a study of negative space, which acts as the common thread that stitches this collection together into a cohesive whole. Through evaluation of relationships, both familial and romantic, with the external world and with the self, I’ve worked to evaluate the space that’s left behind. Each poem features the absence of something or someone that then acts as a mirror to reflect the self, the emotional state that remains. In many, the loss of a close friend is in the fore, where that absence is taken up by grief, longing, and …

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Perceptions Of Assistant Principals Of Curriculum And Instruction Regarding The Effectiveness Of Their Role, Patton Barrett Furman Jan 2020

Perceptions Of Assistant Principals Of Curriculum And Instruction Regarding The Effectiveness Of Their Role, Patton Barrett Furman

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This qualitative phenomenological study explored what assistant principals of curriculum and instruction (APCIs) in a large metropolitan area in central Alabama thought about the effectiveness of their role. APCIs are an emerging role in school administration, therefore there is limited research involving APCIs, including whether the position is effective in practice. More research is needed that pertains to the assistant principal role, but more specifically it is needed for those assistant principals charged primarily with curriculum and instruction (Gurley, Peters et al., 2015). My study will help to fill the gap by looking at the perceptions of current APCIs. This …

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Optical And Electrical Characterization Of Transition Metal And Rare-Earth Metal Doped Ii-Vi Semiconductors For Mid-Ir Laser Applications, Ozarfar Gafarov Jan 2020

Optical And Electrical Characterization Of Transition Metal And Rare-Earth Metal Doped Ii-Vi Semiconductors For Mid-Ir Laser Applications, Ozarfar Gafarov

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The middle-infrared (mid-IR) 2-8 μm and long-wavelength-infrared (LWIR) 8-20 μm spectral range enjoys a lot of attention from the scientific, medical, and industrial communities. A number of applications such as spectroscopy, medical diagnosis, surgical procedures, materials processing, remote detection of organic compounds, free-space-communication, and many others are possible. Transition metal (TM) doped II-VI semiconductors are the materials of choice for accessing the mid-IR. The II-VI host materials feature broad infrared transparency, low phonon frequency, and low optical losses. When doped with TM ions, these media exhibit a four-level energy structure, the absence of excited state absorption, and broad absorption and …

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Peace. Love. Youth. (In) Yoga: Development Of A Mental Health Program Among Adolescents Living In The Inner City, Sherilyn Jonnell Garner Jan 2020

Peace. Love. Youth. (In) Yoga: Development Of A Mental Health Program Among Adolescents Living In The Inner City, Sherilyn Jonnell Garner

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Adolescence is a unique developmental stage during which physical, cognitive, social, and emotional changes occur simultaneously and the traumatic effects of adverse childhood experiences (ACEs) can be particularly salient for the emotional and cognitive development of adolescents as they navigate and adjust to the social environment (Blakemore & Mills, 2014). Seventy-seven percent of Black adolescents have unmet mental health needs, and only 13% of those adolescents receive services compared to 31% of White adolescents. Meeting mental health needs of Black adolescents is imperative as their mental health needs continue to grow and resources become increasingly scarce. Innovative, culturally acceptable, accessible …

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The Non-Protostegid Cretaceous Marine Turtles Of Alabama And Their Bearing On The Evolution Of Extant Chelonioids, Andrew Gentry Jan 2020

The Non-Protostegid Cretaceous Marine Turtles Of Alabama And Their Bearing On The Evolution Of Extant Chelonioids, Andrew Gentry

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The non-protostegid marine turtle fossils recovered from the Late Cretaceous of Alabama may represent some of the most recent common ancestors of modern marine turtles. Despite their evolutionary significance, almost no formal studies have been conducted on these animals for more than 60 years. Many of these species are known from incomplete holotypes which has led to decades of systematic ambiguity and made specific referrals of recently collected fossil material exceedingly challenging. The aim of this study is to review and describe the specimens of Cretaceous marine turtles collected from Alabama to determine if this material can be used to …

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Immunopathogenesis In Fungal Asthma, Matthew Stephen Godwin Jan 2020

Immunopathogenesis In Fungal Asthma, Matthew Stephen Godwin

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Asthma patients are increasingly presenting with asthma that is more difficult to control and treat than in years past. A subset of these patients who are sensitive to fungal species are described as having severe asthma with fungal sensitization (SAFS). Given the severity of disease, there is ever increasing interest in identifying the immune processes underlying SAFS disease pathology and the development of novel therapeutics to improve management. While sensitivity to multiple fungal species has been described in SAFS, none is more common than Aspergillus fumigatus. Here, we describe two previously unrecognized contributors to the amelioration of disease pathology in …

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