Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

University of Alabama at Birmingham

Discipline
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 5071 - 5100 of 35959

Full-Text Articles in Entire DC Network

Electromechanical Mechanisms Of Electromigration - Novel Approaches, Raghavendra Rao Morusupalli Jan 2022

Electromechanical Mechanisms Of Electromigration - Novel Approaches, Raghavendra Rao Morusupalli

All ETDs from UAB

Reliability of today’s interconnect lines in microelectronic devices is critical to product lifetime. The metal interconnects are carriers of large current densities and mechanical stresses, which can cause void formation or metal extrusion into the passivation leading to failure. The modeling and simulation of stress evolution caused by electromigration in interconnect lines and vias can provide a means for predicting the time to failure of the device. Reliability and performance are equally important in the microelectronics industry of today. Product lifetimes are expected to be as high as 10 to 15 years of service. A typical microprocessor has millions of …

Go to article

Modeling Probabilistic Combinational Optimization Problems On Graphs Using Communication Channel, William Ngambou Djakam Jan 2022

Modeling Probabilistic Combinational Optimization Problems On Graphs Using Communication Channel, William Ngambou Djakam

All ETDs from UAB

This thesis studies Combinatorial Optimization Problems (COPs) on graphs that integrate uncertainty in the problem definition. We focus on Probabilistic Combinatorial Optimization Problems (PCOPs), where uncertainty is associated with the presence or absence of subsets of vertices that describe the problem. In general, combinatorial optimization problems are formulated as a Mixed Integer Linear Programming (MILP) model. This process aims to convert elements of decision-making into variables considering related constraints and choosing an objective function. In such cases, it is recommended to define an objective function that is a linear function with linear constraints. Also, when practical problems are formulated as …

Go to article

Sturmian Theorems, Asymptotic Behavior For Eigenvalues, And Spectral Theory For Ordinary Differential Equations With Distributional Coefficients, Minh Nguyen Jan 2022

Sturmian Theorems, Asymptotic Behavior For Eigenvalues, And Spectral Theory For Ordinary Differential Equations With Distributional Coefficients, Minh Nguyen

All ETDs from UAB

We study the theory of ordinary differential equations whose coefficients are distributions of order 0. In the first chapter of the thesis, we present some of the basic facts about the theory of distributions of order 0, the first-order ordinary differential equation with distributional coefficients, and the theory of linear relation associated with these differential equations. In the second chapter, we study the spectral theory of the first order equation with distributional coefficients. In particular, we prove that the adjoint of the minimal relation is equal to the maximal relation, which is a cornerstone for a spectral theory since it …

Go to article

Entanglement Entropy Bound And Emptiness Formation Probability Of The Xxz Spin Chain, Oluwadara Ogunkoya Jan 2022

Entanglement Entropy Bound And Emptiness Formation Probability Of The Xxz Spin Chain, Oluwadara Ogunkoya

All ETDs from UAB

The first part of this thesis covers some of the background materials that are prerequisite to doing research in many body particle problems. The definitions are given from a mathematical point of view and the proofs to most of the results were not included since they can be found in standard texts. The second part was done with Christoph Fischbacher. Here, we consider the Heisenberg XXZ spin-J chain (J ∈ N/2) with anisotropy parameter Δ. Assuming that Δ > 2J (a necessary but not sufficient condition), and introducing threshold energies EK := K (1 − 2J / Δ) , we show …

Go to article

The Identification And Phenotypic Characterization Of Circulating Flagellin Antigen-Specific Cd4+ T Cells In Crohn's Disease Patients, Nadine N. Morgan Jan 2022

The Identification And Phenotypic Characterization Of Circulating Flagellin Antigen-Specific Cd4+ T Cells In Crohn's Disease Patients, Nadine N. Morgan

All ETDs from UAB

The incidence of inflammatory bowel diseases (IBD) is increasing worldwide. Crohn’s disease (CD) and Ulcerative colitis (UC), the two main subtypes of IBD, are chronic intestinal conditions driven by CD4+ T-cell inflammatory responses to commensal antigen. Both conditions are incurable, and medical treatments involve drugs that require long-term usage but have limited efficacy and significant side effects. To develop therapies targeting the antigen-reactive T cells involved in sustaining these conditions, we must first gain knowledge concerning the microbial antigen-reactive T cell phenotypes and functionality in health and disease. To investigate the phenotypic and functional characteristics of the flagellin-reactive T cell …

Go to article

Disease And Diet-Induced Disruption Of Effector T Cell Homeostasis, Patrick Axel Molina Jan 2022

Disease And Diet-Induced Disruption Of Effector T Cell Homeostasis, Patrick Axel Molina

All ETDs from UAB

Homeostatic departure is a central feature across all diseases and disease processes. Currently, the average individual in the US consumes an inordinate quantity of salt. However, it is unclear if only individuals that have proven blood pressure elevation with an acute load of salt should be wary. Here we demonstrate, alongside a growing body of science, that the canonical definition of salt-sensitivity is insufficient. We show that salt-resistant mice demonstrate salt-sensitivity in non-blood pressure focused phenomena, such as the acute activation of CD4+ T cells to mobilize and induce a defective effector cytokine program with high salt. We demonstrate that …

Go to article

Influencing Factors Of Child Pedestrian Safety In Parking Lots And Residential Streets, Jenni Liveoak Jan 2022

Influencing Factors Of Child Pedestrian Safety In Parking Lots And Residential Streets, Jenni Liveoak

All ETDs from UAB

There is ample data from epidemiological sources that suggest pedestrian risks to young children are a dire public health concern. However, there is very little scientific evidence to adequately understand this concern. Two observational studies revealed potential risks to young pedestrians in non-intersection locations. Both studies unobtrusively observed children between 2-10 years of age and an accompanying adult. First, 124 adult/child dyads were observed crossing from a parked vehicle to the building entrance of six local YMCA locations. Results of this study indicate that adult supervision was inadequate with over 67% of children observed to be unsupervised in the parking …

Go to article

Tissue Engineered Cardiac Muscle Patches With Human Pluripotent Stem Cells Enhance The Repairing Efficacy Of Infarcted Cardiac Muscle In Mouse Model, Xi Lou Jan 2022

Tissue Engineered Cardiac Muscle Patches With Human Pluripotent Stem Cells Enhance The Repairing Efficacy Of Infarcted Cardiac Muscle In Mouse Model, Xi Lou

All ETDs from UAB

Myocardial infarction (MI) remains one of the major contributors to heart failure, which can lead to death, and there has been a lack of effective treatments so far. Human pluripotent stem cells (hPSCs) have been found to be an encouraging candidate for MI treatment. But it is facing challenge of low engraftment, limited integration of transplanted cells with host myocardium. To enhance the therapeutic efficacy of stem cell therapy of MI treatment, two approaches have been explored: 1)The first approach was to overexpress N-cadherin (CDH2), a cell-cell adhesion molecule, in human induced pluripotent stem cell-derived cardiomyocytes (CDH2-hiPSC-CMs), and examine its …

Go to article

Investigation Of Zinc Aluminate As A Refractory Material, Somnath Mandal Jan 2022

Investigation Of Zinc Aluminate As A Refractory Material, Somnath Mandal

All ETDs from UAB

As used chrome-based refractories may contain toxic Cr6+, the chrome-free phas-es qandilite (Mg2TiO4) and zinc aluminate (ZnAl2O4, gahnite) are being considered which are known to enhance thermomechanical properties and slag corrosion resistance. The pore generation and deleterious expansion during in situ Mg2TiO4 and ZnAl2O4 for-mation can limit their amount in a refractory composition. Hence, preformed, dense ag-gregates are desirable. Dilatometric studies revealed that when dead burned magnesia (DBM) is combined with industrial anatase instead of rutile, it expanded less (1% versus 7.2%) and the reaction occurred earlier (965℃ compared to 1120℃). The anatase-based qandilite aggregate had 0% porosity and a …

Go to article

Regulation Of Stromal Cells Through Inflammatory Signalling, Victoria Matkins Jan 2022

Regulation Of Stromal Cells Through Inflammatory Signalling, Victoria Matkins

All ETDs from UAB

The bone marrow is a complex organization of hematopoietic and nonhematopoietic cells that form niches to maintain systemic homeostasis during stress and disease. Stromal cells are non-hematopoietic cells first proposed in 1978 in the bone marrow to be essential for hematopoietic stem cells (HSC). Since then, mesenchymal stromal cells (MSC) have been shown to be critical for the HSC self-renewal, retention, and differentiation through chemokines, cytokines, and adhesion molecules. However, like HSCs, MSCs are multipotent progenitors that differentiate into osteoblasts, adipocytes, and chondrocytes to from tissues of the skeletal, endocrine, and connective systems. These multipotent progenitors are tightly regulated in …

Go to article

Power And Sample Size Calculations For Linear Mixed Models Of Longitudinal Data Using The Kenward-Roger Adjusted Wald Test, Tarrant Oliver Mcpherson Jan 2022

Power And Sample Size Calculations For Linear Mixed Models Of Longitudinal Data Using The Kenward-Roger Adjusted Wald Test, Tarrant Oliver Mcpherson

All ETDs from UAB

The linear mixed model has become a popular technique for the analysis of longitudinal data, but Wald test statistics of fixed effects for these models frequently lack well defined distributions. A common approach to this problem uses the Kenward-Roger adjustment, which attempts to approximate the distribution of the Wald statistic by matching its moments obtained via Taylor expansion to those of an F distribution. However, this approach only matches moments obtained under the null hypothesis of no effect and cannot currently be used to approximate the distribution of the test statistic under some alternative hypothesis. This limitation prevents a straightforward …

Go to article

Role Of Electrophysiological Markers In Cognition In Parkinson's Disease, Adeel A. Memon Jan 2022

Role Of Electrophysiological Markers In Cognition In Parkinson's Disease, Adeel A. Memon

All ETDs from UAB

Parkinson's disease (PD) is more than a movement disorder, and non-motor symptoms, including cognitive deficits and sleep disorders, present early and adversely affect the quality of life of a person with Parkinson's disease (PwP). Unfortunately, no pharmacological therapies slow or halt the progression of cognitive decline in PD. A substantial obstacle to developing effective cognitive therapies is the heterogeneous cognitive profile in PD, as well as a lack of a reliable biomarker of cognitive impairment. Moreover, the ideal biomarker would be generalizable, widely accessible, easily measured, non-invasive, and, ideally, modifiable. Unfortunately, thus far, proposed markers of cognitive deficits often include …

Go to article

Exploring The Relationship Between Chronic Stressors And Protective Factors And Preterm Risk In An African American Pregnant Population, Megan Mileski Jan 2022

Exploring The Relationship Between Chronic Stressors And Protective Factors And Preterm Risk In An African American Pregnant Population, Megan Mileski

All ETDs from UAB

BACKGROUND: In the United States, infant mortality is a serious public health issue, particularly for the African American (AA) population. Despite ample research investigating explanations for the significantly higher infant mortality rate (IMR) for AA infants in the United States, the reason for the racial disparity remains unknown. Reports suggest that chronic, life-course stressors may increase risk of preterm birth (PTB), the leading contributor to the high IMR for AA infants. Adverse childhood experiences and perceived racial discrimination, experienced over the life course, have the potential to increase a stress response in AA women, leading to PTB. Psychosocial resources may …

Go to article

Roles Of Chemokine Receptors In T Cell Accmulation In Omental Tumors, Mingyong Liu Jan 2022

Roles Of Chemokine Receptors In T Cell Accmulation In Omental Tumors, Mingyong Liu

All ETDs from UAB

The omentum is an adipose tissue in the peritoneal cavity that contains immune aggregates termed milky spots. Functionally similar to conventional lymphoid tissues, these specialized leukocyte clusters harbor effector and suppressor cells, mount immune responses to antigens, and sustain peritoneal homeostasis. However, the pre-existing leukocytes fail to protect the tissue from tumor colonization. In fact, the omentum is frequently involved in peritoneal metastasis, during which the balance between effector and suppressor immune cells is compromised with the latter gaining dominance. Regulatory T cells (Tregs) represent a major immunosuppressive population in the omentum and rapidly accumulate after tumor implantation. The increased …

Go to article

Elucidating Pgc-1Α And Errγ Gene Regulation In Neurons, Kathlene Lanphear Joyce Jan 2022

Elucidating Pgc-1Α And Errγ Gene Regulation In Neurons, Kathlene Lanphear Joyce

All ETDs from UAB

Neuronal energy production is critical to the function of the entire central nervous system. Without enough ATP, neurons are not able to maintain their synaptic structure or activity, leading to a circuit-wide dysregulation, affecting movement and memory. The main process for ATP production in neurons is oxidative phosphorylation, which is supported by several proteins encoded by nuclear DNA. Transcription of nuclear DNA is regulated by DNA-binding transcription factors and co-activators which recruit other members of the transcription initiation complex to induce gene expression. While important basally, during neurodegenerative diseases such as Parkinson’s Disease, the transcription of these genes is altered …

Go to article

Parent And Healthcare Provider Beliefs About Chlamydia Adolescent Vaccine, Alison P. Footman Jan 2022

Parent And Healthcare Provider Beliefs About Chlamydia Adolescent Vaccine, Alison P. Footman

All ETDs from UAB

Introduction: Chlamydia is the most common bacterial sexually transmitted infection (STI) worldwide and it disproportionally affects young people and those living in the Southern United States. If left untreated chlamydia infections can lead to complications such as infertility and pelvic inflammatory disease. Currently, chlamydia vaccines are being development. A successful chlamydia immunization program would require adolescents to be vaccinated before engagement in sexual activity and would require parental approval and recommendations from healthcare providers. Therefore, this project aims to explore parent and healthcare provider opinions about chlamydia vaccines to identify potential barriers and facilitators to uptake. Because the COVID-19 pandemic …

Go to article

Characterizing The Role Of Tissue-Specific Retinol Dehydrogenases, Kelli Rae Goggans Jan 2022

Characterizing The Role Of Tissue-Specific Retinol Dehydrogenases, Kelli Rae Goggans

All ETDs from UAB

The bioactive form of vitamin A, retinoic acid is essential for development, cellular differentiation, epigenetic modifications, the immune system, and a variety of other processes due to its ability to regulate over 500 genes through activation of nuclear receptors. While many studies have focused on characterizing the biosynthesis and signaling of retinoic acid in embryogenesis, few have focused on adult tissues. Recent research has identified a novel retinol dehydrogenase, retinol dehydrogenase epidermal 2 (RDHE2), and shown RDHE2 is a potent, physiologically relevant retinol dehydrogenase in Xenopus. The work in this dissertation characterizes RDHE2 in mammalian models. We identify a paralog …

Go to article

Shifting The Narrative: Resources Promoting Positive Parenting Independent Of Abuse Risk, Samantha Gonzalez Jan 2022

Shifting The Narrative: Resources Promoting Positive Parenting Independent Of Abuse Risk, Samantha Gonzalez

All ETDs from UAB

Parenting is exceptionally influential during the first few years of children’s lives as this stage represents a sensitive developmental period. Quality of parenting is particularly important and the current empirical focus on prediction of at-risk parenting does not capture the full picture of what contributes to children’s and families’ well-being. Greater understanding of maternal and paternal positive parenting and its contributors—including a focus on potential protective factors to serve as resources—is essential to move family science more reliably toward a model of prevention of adverse outcomes rather than solely intervention. Furthermore, the field continues to be dominated by self-report methods …

Go to article

Transcriptional Regulation Of Metabolism And Synaptic Function In Neurons, Stephanie N. Fox Jan 2022

Transcriptional Regulation Of Metabolism And Synaptic Function In Neurons, Stephanie N. Fox

All ETDs from UAB

Mitochondrial dysfunction, transcriptional dysregulation, and protein aggregation are all unifying features of neurodegenerative disorders, including Parkinson’s Disease. Parkinson’s Disease is a debilitating movement disorder with no known cure, leading sci-entists to explore the underlying etiological contributors to neuronal dysfunction and loss to devise strategies for neuroprotection. Estrogen-related receptor gamma (ERRγ) is a member of a family of transcription factors which regulate the expression of mitochondrial genes. To determine whether ERRγ modulation can provide insight into transcriptional and mitochondrial dysfunction with neurodegeneration, the experiments in this thesis project determined 1) the importance of transcription of mitochondrial genes in disease as regu-lated …

Go to article

Epigenetic Regulation Of Gene Expression In Temporal Lobe Epilepsy, Rebecca Mary Hauser Jan 2022

Epigenetic Regulation Of Gene Expression In Temporal Lobe Epilepsy, Rebecca Mary Hauser

All ETDs from UAB

Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy and is characterized by seizures originating from the temporal lobe of the brain. A frequent seizure focus in TLE is the hippocampus, a structure located within the temporal lobe crucial for its role in memory formation. Seizures are an excess of synchronous excitation in the brain caused by a surplus of excitatory neurotransmission and a lack of sufficient inhibitory transmission. Coordinating the process of neuronal transmission is differential expression of genes likely resulting in an increase or decrease in proteins responsible for neural signaling such as neurotransmitters, ion …

Go to article

Oxygen Cost Of Walking And Its Correlates In Multiple Sclerosis, Brenda Jeng Jan 2022

Oxygen Cost Of Walking And Its Correlates In Multiple Sclerosis, Brenda Jeng

All ETDs from UAB

Multiple sclerosis (MS) is a chronic, neurological disease characterized by demyelination and transection of axons as well as loss of neurons in the central nervous system that may result in poor walking efficiency, indicated by an increase in the oxygen cost of walking (Cw). The Cw is defined as the amount of oxygen consumed per kilogram of body weight per unit distance walked and reflects disability-related gait abnormalities and manifestations and its interaction with the environment. This dissertation involved four research projects. The first project provided an overview of existing research on the Cw in MS and established a research …

Go to article

"A More Complex Experience Of Schooling" And "The Weirdness I Was Looking For": A Grounded Theory Study Of Students' Experiences Of An Immersive, Secondary Arts School, D Bradford Hill Jan 2022

"A More Complex Experience Of Schooling" And "The Weirdness I Was Looking For": A Grounded Theory Study Of Students' Experiences Of An Immersive, Secondary Arts School, D Bradford Hill

All ETDs from UAB

Much research has focused on the significant benefits of integrating arts into general education curriculum, creating community partnerships for arts education, and including arts as stand-alone curriculum for students. Despite a thriving network of fine and performing arts secondary schools in America, there have been few efforts to articulate the phenomenon of immersive, secondary arts schools, their existence, and the experiences and possible benefits to their students within the schools’ cultures, structures, and curricula. Using a constructivist epistemology and a grounded theory methodology, twelve recent graduates of an immersive, secondary arts school in Birmingham, Alabama, the Alabama School of Fine …

Go to article

Il-2-Mediated Stat3 Activation Controls Effector T Regulatory Cell Development, Emma C. Dean Jan 2022

Il-2-Mediated Stat3 Activation Controls Effector T Regulatory Cell Development, Emma C. Dean

All ETDs from UAB

Heterogeneity in phenotype and function of Treg cells is becoming increasingly appreciated, especially in the context of creating potent Treg cell–based therapeutics in the treatment of inflammatory bowel disease. One of the barriers to developing such therapeutics is the limited understanding of the signals that play a role in the development of Treg cell subsets. Here, we found STAT3 signaling to be enriched in induced IL-10 competent Treg (iTreg) cells in the colon. Through the development of a new in vitro system, we found that STAT3 was required for proper development of IL-10 competent iTreg cells and that IL-2 regulated …

Go to article

Integrated Phenotypic And Molecular Expression Circuits In End-Stage Osteoarthritis, Devin J. Drummer Jan 2022

Integrated Phenotypic And Molecular Expression Circuits In End-Stage Osteoarthritis, Devin J. Drummer

All ETDs from UAB

Osteoarthritis (OA) is a debilitating, inflammatory, joint degeneration disorder, and is the most common form of arthritis. Individuals reaching end-stage OA often pursue elective total hip/knee arthroplasty (THA/TKA) to relieve pain and improve mobility and quality of life. However, approximately one third of THA/TKA patients suffer long-term mobility impairments following surgery, likely in part due to an inability to repair the damaged muscle surrounding the diseased joint. Mechanisms driving this impaired recovery remain poorly understood, therefore it is prudent to interrogate the molecular signatures in skeletal muscle at the time of surgery to provide candidate markers that may improve upon …

Go to article

Examining Urban Teachers' Perceptions And Practices Of Family Literacy Partnerships In Schools, Homes, And Communities: A Case Study, Andrea M. Dailey Jan 2022

Examining Urban Teachers' Perceptions And Practices Of Family Literacy Partnerships In Schools, Homes, And Communities: A Case Study, Andrea M. Dailey

All ETDs from UAB

This qualitative case study examined urban teachers' perceptions and experiences of family literacy practices and partnerships in urban schools, homes, and communities during remote learning. Research shows that collaboration among schools, families, and communities can help improve overall educational outcomes and literacy development of children from linguistic and low socioeconomic backgrounds (Curry et al., 2016; Henderson & Mapp, 2002; Taylor, 1989). However, there is limited research on family literacy practices and partnerships in urban settings during remote learning. Therefore, this research explores family literacy practices and partnerships between schools, families, and communities in urban environments to help improve students' literacy …

Go to article

Scalable Subgraph Mining In A Big Graph, Guimu Guo Jan 2022

Scalable Subgraph Mining In A Big Graph, Guimu Guo

All ETDs from UAB

Finding from a big graph those subgraphs that satisfy certain conditions is useful in many applications such as community detection and subgraph matching. These problems have a high time complexity, but existing systems to scale them are all IO-bound in execution. We propose the first truly CPU-bound distributed framework called G-thinker that adopts a userfriendly subgraph-centric vertex-pulling API for writing distributed subgraph mining algorithms. To utilize all CPU cores of a cluster, G-thinker features (1) a highly concurrent vertex cache for parallel task access and (2) a lightweight task scheduling approach that ensures high task throughput. These designs well overlap …

Go to article

Alternating Field Electrospinning For Fabrication Of Inorganic Nanofibers In The Al2o3-Sio2-Mgo System, W Anthony Brayer Jan 2022

Alternating Field Electrospinning For Fabrication Of Inorganic Nanofibers In The Al2o3-Sio2-Mgo System, W Anthony Brayer

All ETDs from UAB

Nanofibrous ceramics are some of the most promising nano-materials but current production methods are too expensive, too slow, and too inconsistent for applications outside of laboratory proof of concepts. The refractors, catalytic, and aerospace industries have long had an interest in these materials because of their superior thermal, physical, and chemical resistant properties. Ceramic nanofiber structures in the Al2O3-SiO2-MgO system were fabricated from polyvinyl butyral based precursor-nanofibers prepared using a novel free-surface alternating field electrospinning method (AFES). Precursor fibers were generated at rates up to 8.8 g/h and collected as 100–300 μm thick sheets suitable for direct conversion into the …

Go to article

Molecular And Cellular Mechanisms Of Resistance Training-Induced Skeletal Muscle Hypertrophic Response Heterogeneity In Older Adults, Margaret Bell Jan 2022

Molecular And Cellular Mechanisms Of Resistance Training-Induced Skeletal Muscle Hypertrophic Response Heterogeneity In Older Adults, Margaret Bell

All ETDs from UAB

Sarcopenia is a decrease in skeletal muscle (SKM) mass occurring with age. This disease is natural, so it is important to increase SKM mass to counteract. This need is seen in diseases leading to muscle atrophy (i.e., insulin resistance and diabetes). The most efficient way to promote SKM hypertrophy is resistance exercise training (RT), however there is high response heterogeneity. To investigate SKM heterogeneity and maximizing SKM hypertrophy, we conducted a double-blind two-site placebo controlled clinical trial: “Metformin to Augment Strength Training Effective Response in Seniors (MASTERS)”. Here participants > 65 years underwent RT for 14 weeks. Measurements of SKM mass …

Go to article

The Role Of Mitochondrial Genetic Background In Cellular Function, Response To Cell Stress And Disease Susceptability, Jamelle A. Brown Jan 2022

The Role Of Mitochondrial Genetic Background In Cellular Function, Response To Cell Stress And Disease Susceptability, Jamelle A. Brown

All ETDs from UAB

There is a differential susceptibility associated with several diseases including cardiovascular disease (CVD) and hypertension, with Blacks being more likely to develop these conditions. Blacks are also more likely to die from these diseases. To explain the genetic etiology underlying CVD pathogenesis, the primary focus has been on nuclear genetics-environmental interactions, whereas the contribution of mitochondrial genetics is less explored. Therefore, we sought to determine whether differences exist in cellular function and response to cell stress in healthy and diseased individuals with distinct mitochondrial genetic backgrounds. To determine this, we sought first to develop a technique to detect and quantify …

Go to article

Mechanotransduction Signaling On Ovarian Cancer Results In Increased Proliferation, Migration, And Chemoresistance In 2d And 3d In Vitro And In Vivo Models, Molly Buckley Jan 2022

Mechanotransduction Signaling On Ovarian Cancer Results In Increased Proliferation, Migration, And Chemoresistance In 2d And 3d In Vitro And In Vivo Models, Molly Buckley

All ETDs from UAB

Mechanical forces imparted on an ovarian tumor have recently been shown to have a grave impact on cancer development, progression, metastasis, and chemoresistance. The forces present include compression throughout the tumor, intrinsic and extrinsic shear stresses from ascitic fluid present in the peritoneal cavity as well as blood flow through the tumor via leaky and disorganized vessels created through tumor angiogenesis, and tension at the tumor periphery because of the constantly growing mass. Studies of the signaling pathways impacted by these mechanical forces could give great insight into new therapeu-tic targets for ovarian cancer, however, these studies have been severely …

Go to article

First Prev Next Last