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The Critical Period Of Long-Term Plasticity In Adult-Born Granule Cells Is Mediated By T-Type Calcium Channels, William Michael Kennedy Jan 2023

The Critical Period Of Long-Term Plasticity In Adult-Born Granule Cells Is Mediated By T-Type Calcium Channels, William Michael Kennedy

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Neurogenesis occurs in the dentate gyrus of adult rodents leading to a heterogeneous population of dentate granule cells (GCs) in the granule cell layer. Adult-born granule cells (abGCs) exhibit a transient period of elevated synaptic plasticity that contributes to their role in dentate gyrus function. Various mechanisms have been proposed to underlie the critical period of plasticity, including minimal GABAergic synaptic inhibition, robust NMDAR2B currents, and high intrinsic excitability conferred by T-type Ca2+ channels. In this collection of work, we investigate the critical period for long-term potentiation (LTP) in 4–6-week-old abGCs. We conclude that GABAergic inhibition regulates LTP in 4-week-old …

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Physiology And Energetics Of Resilient Coral-Dinoflagellate Communities, Elise F. Keister Jan 2023

Physiology And Energetics Of Resilient Coral-Dinoflagellate Communities, Elise F. Keister

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Despite coral reefs declining globally, thermally resilient coral-dinoflagellate communities have been identified, providing insight into how corals can inhabit warmer environments. These corals are able to better resist and recover from thermal stress events compared to adjacent, offshore conspecifics that are found in habitats that have cooler temperatures. To better understand the physiological traits that make corals resilient, I measured the initial tissue biomass and energy reserves of eight coral species. These corals were collected from both warm-water nearshore habitats and offshore reefs with milder temperatures in Palau, Micronesia. Despite contrasting environments, coral tissue similarities between these populations were striking, …

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Impact Of Exercise On Antioxidative-Stress Induced Endoplasmic Reticulum Dysfunction And Cardiac Remodelling, Arun Jyothidasan Jan 2023

Impact Of Exercise On Antioxidative-Stress Induced Endoplasmic Reticulum Dysfunction And Cardiac Remodelling, Arun Jyothidasan

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The gain of function of nuclear factor erythroid 2 like 2 (Nrf2), in the absence of oxidative stress (or toxic insults), its pathophysiology arising from the endoplasmic reticulum and exercise intervention to mitigate the pathology are the focal point of this dissertation. Nrf2, when constitutively expressed, has been previously associated with cardiomyopathy. Chapter II investigated the hypothesis that cardiac-specific expression of Nrf2 (mNrf2-TG) would establish a pro-reductive state and trigger adaptive cardiac remodeling by enhancing the basal antioxidant defense. Through RNA profiling and imaging techniques, the study underscored that while acute preconditioning might prove advantageous against oxidative stress, prolonged pro-reductive …

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Examining The Impact Of The Covid-19 Pandemic And Subsequent Vaccine Availability On Children’S Social Play Opportunities With A Focus On The Autism Community, Jenni Koehler Jan 2023

Examining The Impact Of The Covid-19 Pandemic And Subsequent Vaccine Availability On Children’S Social Play Opportunities With A Focus On The Autism Community, Jenni Koehler

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Play, especially social play, is crucial to child development and impacts their cognitive, socioemotional, and motor growth. Children with an autism spectrum disorder (ASD) have social and motor impairments that act as barriers to their access to these critical social play opportunities. Those who are able to overcome these barriers through therapy have been shown to have better physical and mental outcomes. Unfortunately, the COVID-19 pandemic restricted social play opportunities for all children and disproportionately impacted children with ASD, further widening developmental gaps between them and their non-autistic peers. The development of the COVID-19 vaccine and its availability to children …

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Unintended Pregnancy, Postpartum Contraception, And Healthcare Utilization Among Young Married Women Affected By Hiv In Kenya, Liza M. Kimbo Jan 2023

Unintended Pregnancy, Postpartum Contraception, And Healthcare Utilization Among Young Married Women Affected By Hiv In Kenya, Liza M. Kimbo

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Women with an unintended pregnancy are at risk of a repeat unintended pregnancy. Although use of postpartum contraception is an effective way to prevent repeat unintended pregnancies, the majority of unintended pregnancies globally occur in women who are not using contraception. Unintended pregnancies can have negative health and social consequences for both women and their children. This study aimed to better understand the use of postpartum contraceptives and healthcare services by married women with unintended versus intended pregnancy in south-western Kenya, with a special focus on young women. The study followed an exploratory sequential mixed methods design. In the first …

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Resilience And Vulnerability: The Impact Of Deprivation, Social Capital, And Distance Sensitivity On Mental Health In Covid-19 Vaccine Seekers, Cesar Ivan Landeros Jan 2023

Resilience And Vulnerability: The Impact Of Deprivation, Social Capital, And Distance Sensitivity On Mental Health In Covid-19 Vaccine Seekers, Cesar Ivan Landeros

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The COVID-19 pandemic has inflicted profound challenges upon California, exacerbating disparities in care, access, and health outcomes within vulnerable and deprived communities. Especially, this crisis has led to a surge in mental health issues, with anxiety and depression emerging as predominant psychopathologies, and the rates of anxiety and depression are alarmingly high in disadvantaged communities. In California, the strikingly high prevalence of these symptoms at 31.7%, compared to the national average of 32.3%, sounds a critical alarm. Despite empirical investigations into anxiety and depression rates across a range of demographic groups worldwide—such as survivors, healthcare professionals, children, adolescents, and adults—the …

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Characterizing The Role Of Mapk Phosphatases In Age-Dependent Macrophage Dysfucntion And Increased Suceptiblity To Pneumonia In A Tnf-Dependent Manner, Katherine Lauren Kruckow Jan 2023

Characterizing The Role Of Mapk Phosphatases In Age-Dependent Macrophage Dysfucntion And Increased Suceptiblity To Pneumonia In A Tnf-Dependent Manner, Katherine Lauren Kruckow

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Lower respiratory infections are the primary cause of infectious death among the elderly. One reason for this is ‘inflamm-aging,’ a chronic low-grade inflammatory state that develops with advanced age. Pertinently, our group has shown increases in TNF levels to be responsible for age-dependent macrophage dysfunction (ADMD) and, in turn, enhanced susceptibility to Streptococcus pneumoniae, the leading cause of community-acquired pneumonia. The underlying molecular mechanisms responsible, however, remain unclear. Following adoptive transfer of alveolar macrophages (AM) from aged (18+ months) or young (3-6 month) mice into young mice, followed by infection with S. pneumoniae, we found that aged AM were sufficient …

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Time-Restricted Feeding Attenuates Obesity-Induced Muscle Dysfunction Through Energy Metabolism And Microbiota Modulation, Christopher Livelo Jan 2023

Time-Restricted Feeding Attenuates Obesity-Induced Muscle Dysfunction Through Energy Metabolism And Microbiota Modulation, Christopher Livelo

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Obesity is a global epidemic that affects countless numbers of people caused by genetic and environmental factors including circadian disruption, which poses significant health risks to skeletal muscle physiology and other tissues. While a feeding fasting intervention known as time-restricted feeding (TRF) has been shown to mitigate obesity-related muscle dysfunction, the underlying mechanisms remain a subject of investigation. In this study, we delve into potential mechanisms underlying TRF's protective effects on muscle physiology in the context of diet- and genetic-induced obesity using Drosophila models. Our findings reveal that TRF triggers the upregulation of key genes involved in glycine production (Sardh …

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New Heat Exchanger Modeling In The Passive Heat Removal System Of Vver-1200 Nuclear Power Plants, Bugrahan Mangan Jan 2023

New Heat Exchanger Modeling In The Passive Heat Removal System Of Vver-1200 Nuclear Power Plants, Bugrahan Mangan

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The current work introduces an innovative methodology for modeling heat exchangers inside the passive heat removal system (PHRS) of water-water energetic reactor (VVER) nuclear power facilities. PHRS serves a crucial role in ensuring the secure and effective dissipation of residual heat produced during the shutdown of a reactor. Nevertheless, the current heat exchanger models exhibit deficiencies in terms of their thorough depiction of the geometric structure and thermal properties, hence limiting their precision and suitability for various applications.This study introduces a novel approach to modeling heat exchangers, with a specific emphasis on accurately representing complex geometric characteristics and including thermodynamic …

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Cd151+ T Cell Frequencies As An Immunological Clock That Identifies Premature Immunological Aging In People With Hiv, Mildred Perez Jan 2023

Cd151+ T Cell Frequencies As An Immunological Clock That Identifies Premature Immunological Aging In People With Hiv, Mildred Perez

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Antiretroviral therapy (ART) has greatly improved the life expectancy of People With HIV (PWH), but despite ART, PWH show signs of chronic immune hyperactivation (CIH), which results in the development of early-onset comorbidities, such as metabolic syndrome, diabetes, cardiovascular complications, neurodegenerative impairment, and can-cer. The underlying causes of CIH are, at best, incompletely understood, with suggested roles of microbial translocation, viral coinfections, T cell imbalances, and persistent HIV replication. Given that the CD4+ T cell population is most affected during acute HIV infec-tion, it is surprising that no T cell populations have been identified as drivers of CIH. Herein, we …

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Identifying The Factors Influencing Hiv Testing And Safe Sex Practices: An Ecological Approach, Shekwonya Evelyn Samuel Jan 2023

Identifying The Factors Influencing Hiv Testing And Safe Sex Practices: An Ecological Approach, Shekwonya Evelyn Samuel

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Introduction: HIV (Human Immunodeficiency Virus) is a sexually transmitted infection (STI) that is still a major health issue in the United States and the world. Emerging adults are more likely to engage in risky sexual behaviors such as multiple sexual partners and unprotected sex. HIV testing contributes to ending the HIV epidemic by identifying at-risk individuals and promoting early diagnosis.Methods: Secondary data analyses of the City Health II dataset were conducted to 1) identify the association between HIV testing and risky sexual behaviors among Black/African American emerging adults ages 18-25 years living in Birmingham metro area, 2) use social network …

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Open-Vocabulary Scene Graph Generation With Compositional Prompt-Tuning, Mirza Tanzim Sami Jan 2023

Open-Vocabulary Scene Graph Generation With Compositional Prompt-Tuning, Mirza Tanzim Sami

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Scene graphs are explicit data structures that express the semantics of an image. It is semantically richer than simple image encodings from Convolutional Neural Networks (CNNs) because objects (big or small) are represented as distinct nodes and the relationship between them are expressed as labeled edges in a graph structure. Thus, scene graphs can express not only the visual context of an image but also the relationship context between pairs of objects. This added context information makes scene graphs ideal for several downstream visual language (VL) tasks such as Visual Question Answering (VQA), image captioning, text to image retrieval, and …

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Perceptions Of Comfort And Vison In Center Distance Multifocal Contact Lenses In Non-Presbyopic Adults, D'Ajanee Smallwood Jan 2023

Perceptions Of Comfort And Vison In Center Distance Multifocal Contact Lenses In Non-Presbyopic Adults, D'Ajanee Smallwood

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Purpose: The aim of this study was to assess the subjective performance of four different multifocal contact lenses (MFCLs) amongst a population of adults excluding presbyopes. Methods: Forty-three subjects were fit with up to four different lenses (Biofinity “D” MFCL, NaturalVue MFCL, MiSight 1 Day contact lens, & Intelliwave MFCL). Information about vision and comfort were gathered using subjective assessments. Pupil size data were gathered as secondary outcome measurements. Results: There were no significant differences in ghosting, haloes, and visual clarity between larger and smaller pupils. All MFCLs had reduced overall visual clarity compared to habitual correction except for Biofinity. …

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The Effects Of Mobile Shielding On Scatter Radiation In The Cardiac Catheterization Laboratory, Lancer Smith Jan 2023

The Effects Of Mobile Shielding On Scatter Radiation In The Cardiac Catheterization Laboratory, Lancer Smith

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This research evaluates the effectiveness of a Specialized Cardiac Catheterization Laboratory Shielding Device (SCCLSD) compared to traditional shielding methods in reducing occupational exposure to scattered x-rays, contributing to the ongoing enhancement of radiation safety in the cardiac catheterization laboratory (CCL) setting. The upper component of the SCCLSD comprises a mobile, transparent barrier with lead-equivalent malleable drapes designed to conform to the patient's body contours. It is height-adjustable, creating a protective shield against scatter radiation generated during CCL procedures. The lower portion of the SCCLSD replaces traditional lead-lined drapes, extending further down the table and incorporating additional shielding for staff protection.An …

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Effectiveness Of The Invisalign System For Deep Bite Correction, Jerry D. Spillers Jan 2023

Effectiveness Of The Invisalign System For Deep Bite Correction, Jerry D. Spillers

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Objective: To assess the dental and skeletal changes resulting from correction of a deep bite using Invisalign (Align Technology, Santa Clara, CA, USA).Methods: This is a retrospective case series study which analyzed pre and post treatment cephalograms for 37 adult deep bite patients. Each patient was treated by one, experi-enced clinician using the same treatment protocols. Nineteen variables, ten linear and nine angular. The Wilcoxon analysis was used to determine if there was a significant dif-ference in pre and post treatment variables. Results: Statistically significant differences (P<0.05) occurred for 14 of 19 variables. These include a decrease in Overjet (-0.97 mm), decrease in overbite (-4.07 mm), extru-sion of the upper first molar (0.47 mm), intrusion of the upper incisor (-0.67mm), extru-sion of the lower second molar (1.01 mm), lower first molar (1.20 mm), lower second premolar (1.70 mm), and lower first premolar (1.74 mm), intrusion of the lower incisor (-1.88 mm), proclination of lower incisor, (4.09 ̊), and increase in SN-MP (0.54 mm). A decrease in anterior occlusal plane (AOP) was also statistically significant. Conclusions: Invisalign is an effective treatment modality for correcting dental deep bites through posterior extrusion and anterior intrusion. Minimal skeletal changes are seen when correcting deep bites with Invisalign.

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The Impact Of Diabetes On At-Fault Motor Vehicle Collisions In Older Adults: Visual Function, Medication, And Crash Characteristics, Thomas A. Swain Jan 2023

The Impact Of Diabetes On At-Fault Motor Vehicle Collisions In Older Adults: Visual Function, Medication, And Crash Characteristics, Thomas A. Swain

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Older drivers represent one of the fastest growing age groups of drivers in the United States. Crash risk among older adults, who have the highest prevalence of vision impairment, has been shown to be related to worse visual function. Diabetes mellitus is a chronic health condition affecting more than 23.1 million Americans, and one in three have pre-diabetes. Persons with diabetes are at increased risk of conditions which cause vision loss. Research indicates those with diabetes have higher rates of MVCs. Despite the increased MVC risk among each of these groups, work has yet to evaluate if diabetes modifies the …

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Role Of Gtp Cyclohydrolase I In Glioblastoma, Kaysaw C. Tuy Jan 2023

Role Of Gtp Cyclohydrolase I In Glioblastoma, Kaysaw C. Tuy

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Glioblastoma (GBM) is the most common primary malignant brain tumor in adults with a median survival of 15 months. Poor patient survival is, in part, caused by a stem-like and therapy-resistant population of brain tumor initiating cells (BTICs). BTICs are plastic, with the capacity to overcome oxidative damage. Guanosine triphosphate cyclohydrolase I (GCH1), a rate limiting enzyme in the de novo synthesis of the redox cofactor, tetrahydrobiopterin (BH4), was previously identified as a significant regulator of oxidative stress in BTICs. Reducing oxidative damage in the form of lipid peroxidation is imperative for GBM growth: lipid metabolism is required for the …

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Senior Executive Experience And The Performance Of Healthcare Organizations, John Patrick Walsh Jan 2023

Senior Executive Experience And The Performance Of Healthcare Organizations, John Patrick Walsh

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SENIOR EXECUTIVE EXPERIENCE AND THE PERFORMANCE OF HEALTHCARE ORGANIZATIONS JOHN P. WALSH HEALTH SERVICES ADMINISTRATION ABSTRACT The healthcare industry has become increasingly complex over the past two decades causing concern for stakeholders of hospitals and health systems regarding the future viability. Given the tumultuous times, understanding who is best suited to lead these organizations is essential. While some work has been done studying certain characteristics of the Senior Leaders of these organizations, none have looked at the relationship between the Senior Leader’s work experience comparing those with for-profit experience and those without and performance. Using Upper Echelon’s Theory as a …

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The Influence Of Economic Disadvantage On The Health And Well-Being Of Youth Transitioning To Adulthood, Shanquela Williams Jan 2023

The Influence Of Economic Disadvantage On The Health And Well-Being Of Youth Transitioning To Adulthood, Shanquela Williams

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Young adults transitioning to adulthood from economically disadvantaged backgrounds may experience physical, cognitive, and socio-emotional challenges. Resources and opportunities available during this transition can significantly impact their ability to integrate into society. The impact of economic disadvantage on the well-being of youth transitioning to adulthood remains understudied. The purpose of this study was to understand how economic disadvantage influenced the well-being of youth transitioning into adulthood. This project used longitudinal data from the Panel Study of Income Dynamics (PSID) and its supplements: the Child Development Supplement (CDS) and the Transition into Adulthood Supplement (TAS). Hypothesis one results revealed that young …

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Cognition, Self-Awareness, And Driving After Moderate-To-Severe Traumatic Brain Injury, Christina A. Diblasio Jan 2023

Cognition, Self-Awareness, And Driving After Moderate-To-Severe Traumatic Brain Injury, Christina A. Diblasio

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Moderate-to-severe traumatic brain injury (TBI) often results in cognitive deficits in learning/memory, executive functions, and self-awareness. Cognitive impairments and unawareness of those impairments hinder driving capacity, yet a large proportion of survivors return to driving after injury. Given that many survivors are driving, it is essential to understand how cognition and self-awareness impact driving practices. To date, studies in this area are limited. This dissertation aimed to (1) create a normative sample for the Brief Test of Adult Cognition by Telephone (BTACT), a short cognitive battery adapted for telephone administration and validated for the TBI population; (2) examine the relationship …

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Restoring Justice On Their Terms: The Path To Healing For Tulsa And Birmingham, Kameryn Thigpen Jan 2023

Restoring Justice On Their Terms: The Path To Healing For Tulsa And Birmingham, Kameryn Thigpen

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This thesis is a comparative case study examining the impact of the Tulsa Race Massacre in 1921 and the Birmingham Sixteenth Street Church Bombing in 1963. The comparative case study method aims to study how both communities educated the public about racial violence through the nonprofit sector. This research explores the racial structures that were in place during the time. This thesis argues for the role of the government in providing diversity, equity, accessibility, and inclusion training for federal employees. This research also discusses the government's contribution to advancing social equity.

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The Influence Of A Low Glycemic Load Diet On Appetite In Women With Pcos, Sarah Et Hoover Jan 2023

The Influence Of A Low Glycemic Load Diet On Appetite In Women With Pcos, Sarah Et Hoover

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Dysregulated appetite may contribute to weight gain and high prevalence of comorbid obesity in women with polycystic ovary syndrome (PCOS), yet dietary recommendations to promote satiety and facilitate weight maintenance in this population remain scarce. The objective of this dissertation was to determine if women with PCOS have alterations in appetite-regulating hormones that can be manipulated by low glycemic load diet habituation to improve satiety. This was tested by secondary analyses of two randomized controlled dietary intervention trials in women with and without PCOS. First, we explored differences in women with and without PCOS during a standardized liquid meal test …

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Production, Purification And Radiochemistry Development Of Manganese-52 Fir Characterization Of Pet/Mr Imaging Agents, Jennifer Marie Pyles Jan 2023

Production, Purification And Radiochemistry Development Of Manganese-52 Fir Characterization Of Pet/Mr Imaging Agents, Jennifer Marie Pyles

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Manganese (Mn) has the potential to be an important element in biomedical research as different isotopes of Mn have the characteristics to be used for both positron emission tomography (PET) and magnetic resonance imaging (MRI). Manganese(II) (55Mn) is paramagnetic which makes it useful as a contrast agent in T1-weighted magnetic resonance imaging (MRI). Mn as a radiotracer provides excellent sensitivity for studying 55Mn, but only Manganese-52 (52Mn) met the criteria for this research. 52Mn has a half-life (t1/2 = 5.591 days) that was long enough to optimize purification, chemistry and examine timepoints over several days. 52Mn decays by positron emission …

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Expansion In Eigenfunctions For Systems Of Ordinary Differential Equations Without The Unique Continuation Property, Steven Redolfi Jan 2023

Expansion In Eigenfunctions For Systems Of Ordinary Differential Equations Without The Unique Continuation Property, Steven Redolfi

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In this document we consider differential equations where the coefficients are matrices whose entries are distributions of order zero satisfying certain criteria. The derivative which occurs in the equation is the distributional derivative. Chapter 1, sections 1-7 contain information necessary to understand for the reading of Chapters 2 and 3. Section 8 gives a brief introduction to what has been done so far and our goal. Thereafter, in Chapter 2, it is shown that self-adjoint restrictions of the maximal relation to the differential equation are still given by boundary conditions. With that done, given a self-adjoint restriction of the maximal …

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Development And Evaluation Of A Nanomatrix Coated Stent Using A Vascular Sheet With Atherosclerosis Model, Xixi Zhang Jan 2023

Development And Evaluation Of A Nanomatrix Coated Stent Using A Vascular Sheet With Atherosclerosis Model, Xixi Zhang

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While cardiovascular stent technology has considerable advances, there are hurdles to overcome due to the dysfunctional stented arteries which fail to maintain vascular homeostasis. Current stent designs ignored the significance of promoting functional artery healing (pro-healing). Therefore, we developed a pro-healing nanomatrix coating for stent. Previous studies investigated its effect on individual vascular cell type. In natural artery, there are multiple vascular cell types that strongly affect stent performance. Thus, an in vitro vascular double-layer (VDL) system was used to observe stent effects on different vascular cell types. And the pro-healing ability and mechanism of the nanomatrix coated stent were …

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Impacts Of Transportation Network Companies On Urban Congestion In A Medium-Sized City, Furat Shakir Salman Jan 2023

Impacts Of Transportation Network Companies On Urban Congestion In A Medium-Sized City, Furat Shakir Salman

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The rise of ride-hailing and on-demand transportation services offered by Transportation Network Companies (TNCs) (such as Uber and Lyft) has been one of the key factors contributing to the growth of shared mobility services in recent years. The presence of contradictory findings on the impacts of TNCs necessitates the undertaking of an investigation into the shifts in mode choice that occur in the context of TNC services and their impacts on urban congestion. As a result of difficulties in gathering TNCs field data, it is still not possible to fully assess the impact of these services on urban congestion. Moreover, …

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Investigation Of Fish Gelatin/Polycaprolactone Nanofibrous Materials Alternating Field Electrospinning Fabrication And Characterization, Hannah A. Lacy Jan 2023

Investigation Of Fish Gelatin/Polycaprolactone Nanofibrous Materials Alternating Field Electrospinning Fabrication And Characterization, Hannah A. Lacy

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As human needs and purposes continue to evolve, it has become crucial that the materials with which we address these new applications and challenges evolve in stride. Specifically, the medical field’s need for advanced materials has led to the drive for biomaterial synthesis and processing methods which produce adaptable material characteristics to satisfy application specific needs. Research response has been to expand viable natural/ synthetic biomaterial resources, design innovative nanofiber fabrication techniques with high levels of productivity, ease of access, and cost efficiency, and explore crosslinking and surface treatments/modifications to enhance material characteristics for improved performance. This research employs select …

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Molecular Mechanisms Of Amphetamine Abuse, Samuel James Mabry Jan 2023

Molecular Mechanisms Of Amphetamine Abuse, Samuel James Mabry

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Amphetamine (AMPH), a psychostimulant commonly prescribed for the treatment of neuropsychiatric and neurological disorders, has a high liability for abuse. The stimulant properties of AMPH are primarily associated with its ability to increase dopamine (DA) neurotransmission. This increase is mediated by non-vesicular DA release (DA efflux). This DA efflux is the result of the reversal of the DA transporter (DAT), which is promoted by AMPH. Syntaxin 1 (Stx1), a SNARE protein, interacts with the DAT N-terminus. Stx1 is phosphorylated at Ser14 by casein kinase II (CK2). This phosphorylation site contributes to the DAT/Stx1 interaction and is critical for allowing DAT …

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A Cold Plasma-Enabled Reduction Process For The Fabrication Of Metallic Nanostructures Onto Polymeric Biomaterials, Gerardo Hernández Moreno Jan 2023

A Cold Plasma-Enabled Reduction Process For The Fabrication Of Metallic Nanostructures Onto Polymeric Biomaterials, Gerardo Hernández Moreno

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The design and manufacture of novel materials has served as the bedrock for tissue engineering and regenerative medicine. There exists a need for more biocompatible implantable materials in the biomedical device space. The approach to developing biomaterials fit for biomedical devices has been focused on decreasing overall physiological interaction with the local environment. However, the development of more biomechanically favorable materials has placed an emphasis on designing materials that display biomimetic and biomechanical properties resembling that of the host tissue at the implant site. As biomaterials engineering has progressed, the race to find materials that interact at the nano- and …

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Patient-Driven Payment Model And The Covid-19 Pandemic External Environment Impact On Nursing Home Industry In The Last 5 Years, Gregory N. Orewa Jan 2023

Patient-Driven Payment Model And The Covid-19 Pandemic External Environment Impact On Nursing Home Industry In The Last 5 Years, Gregory N. Orewa

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Nursing homes face an ever-changing environment and must adapt to achieve organizational success. Recent events such as the COVID-19 pandemic and the implementation of the Patient-Driven Payment Model (PDPM) reimbursement policy have disrupted nursing homes. PDPM put pressure on nursing homes to change their operations and billing practices. The reimbursement policy changed from Resource Utilization Group (RUG) under the Prospective Payment Model (PPS), to PDPM. PDPM, which encourages more value in skilled nursing facility (SNF) spending, has been explored by various studies with respect to nursing home’s reaction in reducing therapy staffing. Three studies follow that examine PDPM and COVID-19 …

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