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Analytical Methods Using Cardiac Mri To Assess Systolic And Diastolic Ventricular Function, Muhammad Rifqi Aufan Jan 2023

Analytical Methods Using Cardiac Mri To Assess Systolic And Diastolic Ventricular Function, Muhammad Rifqi Aufan

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Magnetic resonance imaging (MRI) has proven invaluable for clinical and research investigations due to its minimal invasiveness and excellent measurement precision and reproducibility. In particular, Cardiac MRI (CMR) is a powerful tool for evaluating anatomical and functional properties of the left ventricle (LV). In this study, two aspects of CMR applications of the LV are investigated: 1) assessment of diastolic function by quantifying LV stiffness index and related properties as a representation of intrinsic myocardium properties in patients with diastolic dysfunction and 2) evaluation of systolic function by relating myocardial strain and LV geometrical configuration with ejection fraction (EF). The …

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Gender Differences In Clinical Profiles Of Children And Adolescents Referred For An Autism Spectrum Disorder Evaluation, Jeremy J. Cottle Jan 2023

Gender Differences In Clinical Profiles Of Children And Adolescents Referred For An Autism Spectrum Disorder Evaluation, Jeremy J. Cottle

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The current study aimed to examine sex differences in clinical profiles of children and adolescents referred for an ASD evaluation, including ASD symptoms and associated clinical features. Specifically, the study aimed to include females who may be mis- or un-der-diagnosed by current ASD diagnostic procedures in order to characterize this phenotypically diverse population. Participants included 1,099 children and adolescents who were referred for an ASD evaluation at a tertiary care clinic. In this sample, 276 participants (25.11%) were female, 602 participants (54.8%) were diagnosed with ASD, and the average age was 5.97 years old (SD = 3.60). Independent samples t-tests, …

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Rural Healthcare Disparities In Preschool Children Referred For An Autism Spectrum Disorder Evaluation, Zachary Enos Arnold Jan 2023

Rural Healthcare Disparities In Preschool Children Referred For An Autism Spectrum Disorder Evaluation, Zachary Enos Arnold

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Disparities in healthcare are widespread in rural communities, and families with a preschooler with suspected autism spectrum disorder (ASD) might be especially impacted by a dearth of services. By exploring the information gathered from ASD diagnostic visits, the goal of the current study was to inform future research that aims to address access to quality care in the communities that need assistance the most. It was hypothesized that increasing rurality would worsen the following metrics: barriers to care (e.g., social disadvantage & pediatrician availability), clinical evaluation outcomes (e.g., age of diagnosis, language functioning, adaptive functioning, ASD severity), and access to …

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Indicators Of The Social Environment And Cognition In An Older Population Of Puerto Rican Adults, Erin E. Ballard Jan 2023

Indicators Of The Social Environment And Cognition In An Older Population Of Puerto Rican Adults, Erin E. Ballard

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Isolation and other indicators of poor social environment have been associated with a higher risk of cognitive decline. Overall evidence for this association is mixed, with most studies being conducted in Western, educated, industrialized, rich, and democratic (aka “WEIRD”) societies. Religiosity may moderate this relationship between less robust social environments and cognition by buffering the negative effects of stress. The primary aim of this study is to assess the relationship between indicators of the social environment and psychological distress (depressive symptoms) and cognitive decline in a population-based sample of older Puerto Rican adults (n=3,557) across two time-points. Social environment included …

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Dietary Adherence During Weight Loss And Attendance To Weight Management Support Are Independently Related To Weight Gain, Emily Pounds Jan 2023

Dietary Adherence During Weight Loss And Attendance To Weight Management Support Are Independently Related To Weight Gain, Emily Pounds

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Although people can lose weight by restricting calories and increasing energy ex-penditure, only a small percentage are successful at maintaining the loss. PURPOSE: Therefore, the purpose of this study is to identify factors that may predict who is more likely to gain weight and visceral fat back after weight loss, and to evaluate the efficacy of a weight maintenance support group (EatRight) during 12 months of weight mainte-nance. METHODS: Subjects (n=85) were healthy, overweight [body mass index (BMI) 27–30 kg/m2, mean weight 77.6 kg] premenopausal women (age 34). Data were collect-ed at baseline, immediately after weight loss, and 1-year post-weight …

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Analyzing Cannabinoid Stability In Different Conditions And Validating Novel Cannabinoids For Oral Fluid Analysis, Cody Paseur Jan 2023

Analyzing Cannabinoid Stability In Different Conditions And Validating Novel Cannabinoids For Oral Fluid Analysis, Cody Paseur

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Oral fluid (OF) drug testing has been expanded to laboratory evidentiary confirmation testing in driving under the influence (DUI) cases. OF samples are collected by officers at the roadside using collection devices such as the Quantisal® device. Tetrahydrocannabinol (Δ9-THC) was the most prevalent drug in Alabama DUI casework in 2022. Δ9-THC remains a Schedule I drug in Alabama and federally. Current validated targets in cannabinoid oral fluid testing include Δ9-THC, Δ8-THC, 9R-Δ10-THC, 9S-Δ10-THC 11-hydroxy-Δ9-THC (THC-OH), 11-nor-9-carboxy-Δ9-THC (THC-OOH), cannabigerol (CBG), cannabidiol (CBD), and cannabinol (CBN). Due to the 2018 Farm Bill, cannabinoids derived from hemp with a Δ9-THC concentration less than …

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Chronic Hiv Infection Influences The Immune Response To Sars-Cov-2, Skye Opsteen Jan 2023

Chronic Hiv Infection Influences The Immune Response To Sars-Cov-2, Skye Opsteen

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused global morbidity and mortality since late 2019. Many infections result in self-limited disease and recovery in 1-2 weeks. However, a subset of individuals experience more severe illness, associated with hospitalization, ventilation, and potential mortality. HIV infection is a proposed risk factor for more severe illness due to people living with HIV (PLWH) experiencing chronic immune activation and inflammation despite effective antiretroviral therapy. While there is supporting evidence showing worsened clinical outcomes in PLWH experiencing acute COVID-19, the immune response driving these outcomes is less explored. We analyzed markers of immune activation …

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Processing And Non-Destructive Evaluation Of Overmolded Thermoplastic Composites, Ibrahim Gundogdu Jan 2023

Processing And Non-Destructive Evaluation Of Overmolded Thermoplastic Composites, Ibrahim Gundogdu

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The overmolding process is one of the newly developed composite processing methods which allow to integrate continuous and discontinuous fiber reinforced composites for weight and cost reduction for a variety of applications. Continuous fiber reinforced thermoplastics (CFRTs) exhibit excellent mechanical properties such as high impact strength and stiffness, however forming them into complex shapes is challenging and the processing cost is high. On the other hand, the processing of discontinuous fiber reinforced composites, including long fiber reinforced thermoplastics (LFTs), into complex shapes is relatively easy compared to continuous fiber composites because of their high processibility. The integration of both continuous …

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Diagnostic Outcomes Of Digital Images For Comprehensive Examination In Pediatric Dentistry: An Intraexaminer Agreement Assessment, Maria Fernanda Montoya Jan 2023

Diagnostic Outcomes Of Digital Images For Comprehensive Examination In Pediatric Dentistry: An Intraexaminer Agreement Assessment, Maria Fernanda Montoya

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Purpose: To Assess intra-examiner diagnoses obtained via traditional oral clinical examination (TCE) versus digital oral examination (DOE) completed from digital video images of pediatric patients. Methods: Fifty pediatric patients 5 to 10 years of age, who attend the Pediatric Dentistry Clinic at the University of Alabama at Birmingham (UAB) for initial consultations or regular visits were included in this study. Individual oral comprehensive examinations were done by five second-year pediatric dentistry residents. A trained dental hygienist recorded a full mouth intraoral video for each patient via MouthWatch intraoral camera and stored using existing Information and Communication Technology (ICT) infrastructure. After …

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Development And Validation Of A Multiplex Str Amplification Reaction For Academic And Research Purposes, Ahana Chatterjee Jan 2023

Development And Validation Of A Multiplex Str Amplification Reaction For Academic And Research Purposes, Ahana Chatterjee

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Short Tandem Repeat (STR) typing has been accepted globally as a gold standard for human identity testing. In 1997, the Federal Bureau of Investigation (FBI) Laboratory’s newly developed Combined DNA Index System (CODIS) consisted of 13 core loci to be targeted while DNA typing. In this context, leading biotechnology companies like Promega (Madison WI), Applied Biosystem/Life Technologies (Foster City, CA) etc. offer commercial STR typing kits for crime laboratories. However, these expensive kits are not the most suitable for academic and research laboratories. Students learning the method of STR typing and researchers showing proof of concept do not require identifying …

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Synthesis, Characterization, And Evaluation Of A Bionanomatrix And Antibiotic-Releasing Liposomes On Osseointegration, Vascularization, Inflammation, And Antibacterial Efficacy, Benjamin Kade Estep Jan 2023

Synthesis, Characterization, And Evaluation Of A Bionanomatrix And Antibiotic-Releasing Liposomes On Osseointegration, Vascularization, Inflammation, And Antibacterial Efficacy, Benjamin Kade Estep

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Percutaneous osseointegrated prostheses (POP) implants combat the multitude of issues and limitations of contemporary prosthetic sockets/limbs, including range of motion, comfort/fit, irritation, gait, and osseoproprioception. However, POP implants lack long-term clinical success; specifically, several risks exist at the bone-implant interface, including superficial/deep infections, inflammation, poor vascularization, and inadequate osseointegration, resulting in implant loosening over time and ultimately removal of the implant. The goal of this thesis is to evaluate a multifunctional, nitric oxide-releasing bionanomatrix incorporated with antibiotic-releasing liposomes on osseointegration, inflammation, vascularization/angiogenesis, and bacterial infection. We successfully synthesized the bionanomatrix, and the antibiotic-releasing liposomes readily encapsulated the antibiotics. The antibiotic-releasing …

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Flexural Behavior Of Composite Frp-Concrete-Steel Poles, Krenar Krasniqi Jan 2023

Flexural Behavior Of Composite Frp-Concrete-Steel Poles, Krenar Krasniqi

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A new composite pole is being developed. The pole consists of an outer fiber reinforced polymer (FRP) shell, inside steel tube, and concrete filled between the two tubes (The composite FRP-concrete-steel pole is hereafter referred to as CFCSP). The FRP tube used in this research is produced using a centrifugal casting technique with glass-fibers oriented in the longitudinal and hoop direction. The longitudinal fibers provide flexural resistance to the section, whereas the hoop fibers confine the concrete and give shear resistance to the pole. The steel tube acts as longitudinal reinforcement, and the concrete is confined by the two tubes. …

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Preceding Footsteps In Revolution: The History Of The Southern Negro Youth Congress, Donnae' Hampton Jan 2023

Preceding Footsteps In Revolution: The History Of The Southern Negro Youth Congress, Donnae' Hampton

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This thesis is a comprehensive history of the Southern Negro Youth Congress including the social circumstances that led to its formation, the work and people of the organization, and its impact and influence on future civil rights organizations and Black leftist movements of the late 1960s. The Southern Black communist organization was formed in 1937 and officially disbanded in 1949. SNYC committed itself to unionizing, educating, registering people to vote, and exposing racial horrors in the South for Black southerners. In 1939, SNYC moved its headquarters to Birmingham, Alabama. The segregated city of Birmingham in 1939 was the industrial center …

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Accuracy Of Ancestry Estimation In Forensic Anthropology: An Examination Of Select Nonmetric Methods, Mackenzie Miller Jan 2023

Accuracy Of Ancestry Estimation In Forensic Anthropology: An Examination Of Select Nonmetric Methods, Mackenzie Miller

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A goal of forensic anthropology is to aid in identifying unidentified human remains, often by creating a biological profile. An important piece of this profile is an ancestry estimate, and methodological accuracy is taken seriously. Traditional typological nonmetric methods of ancestry are heavily critiqued for being subjective and lacking scientific rigor in analysis. In addition, these methods are noted for conflating morphological traits with specific ancestral categories, ignoring the reality of continuous human variation. To combat this, scholars have proposed morphoscopic nonmetric methods as an alternative because they retain the accessibility popularized by typological methods but add a layer of …

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Canonical Laminations For Fixed Point Portraits, Md. Abdul Aziz Jan 2023

Canonical Laminations For Fixed Point Portraits, Md. Abdul Aziz

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Laminations are a combinatorial and topological model for studying the Julia sets of complex polynomials. Every complex polynomial of degree d has d fixed points counted with multiplicity. From the point of view of laminations, exactly d−1 of these fixed points are peripheral (approachable from outside the Julia set of the polynomial). Hence, at least one of the d fixed points is “hidden” from the laminational point of view. The purpose of this thesis is to identify, classify and count the possible fixed point portraits for any lamination of degree d. We will identify the “simplest” lamination for a given …

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Persuasion In Descriptions Of Medical Crowdfunding On Gofundme: When Children Fundraise For Their Mothers' Lung Cancer, Ziyu Zhao Jan 2023

Persuasion In Descriptions Of Medical Crowdfunding On Gofundme: When Children Fundraise For Their Mothers' Lung Cancer, Ziyu Zhao

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Medical needs have become one of the top categories in online crowdfunding in the United States (Chandler, 2015). However, the level of donations falls short of what is needed to cover the high costs of healthcare (Norton, 2022; Young & Scheinberg, 2017). Therefore, more successful promotion of medical crowdfunding campaigns is crucial. This thesis research examined the influence of two persuasive factors, appeal type and cover images, in medical crowdfunding of lung cancer on backers’ donation behaviors on GoFundMe with manual coding and Linguistic Inquiry and Word Count (LIWC). The study found no statistically reliable support for the hypotheses, perhaps …

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Comparing The Efficiency Of Molar Protraction Using Herbsts And Temporary Anchorage Devices, Ishita Zem Taneja Jan 2023

Comparing The Efficiency Of Molar Protraction Using Herbsts And Temporary Anchorage Devices, Ishita Zem Taneja

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Objective: The purpose of this study is twofold. First, to assess the utilization of the Herbst device in mandibular molar protraction. Second, to compare the effectiveness of the protraction Herbst and TADs in patients with congenitally missing mandibular second premolars. Methods: This project was designed as a retrospective study. Orthodontic patients with unilateral or bilateral congenitally missing mandibular premolars, who received the protraction Herbst appliance or TADs as part of their treatment were included in the study. We excluded patients treated with maxillary counterbalancing extractions. Our final patient sample included a total of 33 patients (22 females and 11 males). …

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Strategic Balance In Healthcare Organizations, Corey Spraberry Jan 2023

Strategic Balance In Healthcare Organizations, Corey Spraberry

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The purpose of this dissertation was to assess the relationship between service mix offerings relative to competitors and firm performance. Specifically, this study explores if an optimal point of service offerings in the competitive market is associated with financial performance. This study is important to both researchers and healthcare leaders as it helps understand the relationship between optimal service mix and firm performance. The results find a relationship that suggests a differentiated service mix compared to a generalized service mix is associated with financial performance. Additionally, hospital characteristics are associated with service duplication and differentiation. The findings of this research …

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Increasing Naloxone Access For Persons Who Use Opioids: An Online Recruitment And Training Approach To Opioid Overdose Education And Naloxone Distribution, Michelle L. Sisson Jan 2023

Increasing Naloxone Access For Persons Who Use Opioids: An Online Recruitment And Training Approach To Opioid Overdose Education And Naloxone Distribution, Michelle L. Sisson

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Drug overdose is the primary cause of accidental death in the United States, with a majority of those fatalities involving opioids. Annual rates of fatal opioid overdoses have exponentially increased over the past two decades, leading to the declaration of the current opioid epidemic. The severity of the epidemic has increased due to an upsurge in the use of heroin, synthetic opioids (e.g., fentanyl), and the lacing of other substances with synthetic opioids. As such, federal agencies have made recommendations aimed at combating fatal opioid overdose including the enhancement of naloxone distribution. Administration of naloxone has been expanded from emergency …

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Quantitative Analysis Of The Impact Of Automatically Generated Normal Tissue Contours On Knowledge-Based Planning Model Quality, Samuel Christopher Baker Arnold Jan 2023

Quantitative Analysis Of The Impact Of Automatically Generated Normal Tissue Contours On Knowledge-Based Planning Model Quality, Samuel Christopher Baker Arnold

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While radiotherapy has become one of the primary standards of treatment for cancer in areas such as the brain, treatment plans are limited by the time it takes physicians to contour CT images used for dose distribution calculations. Automation of the contouring process can not only improve the rate of plan formation but establish an improved standard of care. With the development and implementation of knowledge-based planning (KBP) in radiation oncology, information derived from treatment plans provide machine learning models with years of experience to assess and create future treatment plans. Since KBP model quality rely on contouring from training …

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Rates, Presentation, & Effects Of Public Autism Stigma, Monica Abdul-Chani Jan 2023

Rates, Presentation, & Effects Of Public Autism Stigma, Monica Abdul-Chani

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Limited availability of resources regarding developmental issues, health literacy, linguistic-sensitivity (i.e., use of linguistically appropriate resources and measures), structural barriers (i.e., appointment length, transportation), and cultural values and beliefs are commonly-cited barriers in identifying Latine autistic children. Stigma may also play a role, as it is negatively related to both knowledge/awareness within ASD and to acculturation in other disorders (i.e., HIV). Stigma can have detrimental, pervasive effects on daily living for those stigmatized and their families. Limited research examined the rate, presentation, and effect of ASD stigma within the Latine community, and all available studies explored stigma as reported by …

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An Exploration Of The Values Elicitation Experiences Of Patients With Heart Failure And Their Family Caregivers, Avery Bechthold Jan 2023

An Exploration Of The Values Elicitation Experiences Of Patients With Heart Failure And Their Family Caregivers, Avery Bechthold

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Values, defined as abstract, subjective, and significant core beliefs, which function within a system and priority, are integral to how individuals make decisions, and cope with stressors, including serious illness. However, little research has been conducted to explore the experiences of patients with heart failure (HF) and their family caregivers. Therefore, the purpose of this dissertation was to explore how values are discussed, reflected upon, and acted on by patients with HF and their family caregivers. This purpose was accomplished through four manuscripts and a mixed methods analysis: 1) a concept analysis of values elicitation in the context of health …

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I Would Be Shocked If Someone’S Not Depressed With That Diagnosis”: An In-Depth Exploration Of The Manifestation And Management Of Depression And Anxiety In Patients With Cancer, Carmen Rainey Brown Jan 2023

I Would Be Shocked If Someone’S Not Depressed With That Diagnosis”: An In-Depth Exploration Of The Manifestation And Management Of Depression And Anxiety In Patients With Cancer, Carmen Rainey Brown

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Patients diagnosed with cancer experience depression and anxiety at higher rates compared to the general population. Most individuals diagnosed with cancer will experience symptoms of depression and anxiety at some point during their cancer trajectory and not seek care leaving their mental health conditions undiagnosed and untreated, which impact quality of life and cancer outcomes. Patient and providers perspectives are vital to understand the manifestation, care-seeking behaviors, and provider management of depression and anxiety in patients with cancer. This study sought to explore the manifestation of depression and anxiety among patients with cancer and their care seeking behaviors for mental …

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Socioeconomic Challenges Of Long Covid, Justin Catt Jan 2023

Socioeconomic Challenges Of Long Covid, Justin Catt

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Long COVID, also known as post-acute sequelae of SARS-CoV-2 infection or PASC, is a condition resulting from a SARS-CoV-2 infection characterized by continuing or novel symptoms across multiple organ systems occurring at least four weeks after infection. Symptoms of Long COVID can include cognitive impairment, memory loss, and fatigue. Although associations between COVID-19 and social determinants of health have been studied, noting that disadvantaged socioeconomic or racial groups have higher incidence and mortality rates from COVID-19, the associations between Long COVID and social determinants of health have not been robustly examined. Using data from the Household Pulse Survey in Summer …

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Conceptual Architecture For Digital Twin Implementation In A Smart City Framework, Wesley Conwell Jan 2023

Conceptual Architecture For Digital Twin Implementation In A Smart City Framework, Wesley Conwell

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More than 9 billion people are expected to live on the planet in 2050, about two-thirds in cities. This substantial population growth in urban areas increases demands on cities' resources, services, and infrastructure. Hence, many cities leverage intelligent technologies to ensure urban communities' efficiency in integrating massive infrastructure components and services. Cities define this reconstruction of their operational framework as a smart city. Effective resource consumption management in a smart city integrative structure presents a problem with solutions concerning the distribution of city services. This dissertation aims to establish a conceptual framework to effectively manage resource consumption in a smart …

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Unveiling The Unknown Rna-Binding Landscape Of Srsf1, Naiduwadura Ivon Upekala De Silva Jan 2023

Unveiling The Unknown Rna-Binding Landscape Of Srsf1, Naiduwadura Ivon Upekala De Silva

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SRSF1 is a prototypical SR protein and its interactions with single stranded RNA (ssRNA) are crucial in mRNA splicing. Its RNA-binding specificity is governed by the RNA-binding Domain (RBD), which contains two RNA Recognition Motifs (RRMs) tethered by a flexible linker. Its C-terminal unstructured Serine-Arginine-rich (RS) domain has been believed to bind RNA non-specifically so far. Although SRSF1 is known to bind a variety of RNA containing its RRM-cognate motifs, its interactions with such RNA have been poorly characterized. Therefore, we explore how SRSF1 achieves a broad RNA-binding specificity ranging from ssRNA to G-quadruplex (GQ) RNA. According to our Fluorescence …

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The Er Stress-Pathogen Nexus In Regulation Of Cell Death In Arabidopsis Immunity, Danish Diwan Jan 2023

The Er Stress-Pathogen Nexus In Regulation Of Cell Death In Arabidopsis Immunity, Danish Diwan

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Pathogens and plants are involved in a coevolutionary battle for dominance. As plants lack adaptive immune systems, they rely on their innate immunity to protect themselves from infectious agents. Upon pathogen attack, plant cells activate their pro-survival strategy by recognizing the pathogen and actively transcribing and translating proteins to effectively defend against the pathogen infection. As the intensity of infection increases, the heightened demand for proteins places an excessive burden on the ER machinery resulting in the accumulation of misfolded or unfolded proteins within the ER. To restore the protein homeostasis, a cellular relief signaling pathway called Unfolded Protein Response …

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Investigation Of Reversibility And Nucleotide Effects In The Kinetic Mechanisms Of Nucleotide Addition In The Eukaryotic Rna Polymerases, Kaila B. Fuller Jan 2023

Investigation Of Reversibility And Nucleotide Effects In The Kinetic Mechanisms Of Nucleotide Addition In The Eukaryotic Rna Polymerases, Kaila B. Fuller

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Eukaryotes utilize at least three multi-subunit DNA dependent RNA polymerases (Pol I, II, and III) to synthesize RNA. The Pols are similar in structure but have distinct kinetic mechanisms that describe nucleotide addition. The product of Pol I synthesis, ribosomal RNA (rRNA) comprises the majority of the ribosome and is necessary for gene expression. Despite the importance of Pol I transcription in the cell, there is still much to understand about the roles of specific subunits in Pol I and the different factors that affect the kinetic mechanism of nucleotide addition catalyzed by Pol I. Our group has previously published …

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The Relative Impact Of Transformational Leadership On The Academic Optimism Of High Poverty Urban Elementary Schools In Alabama, Cheritta Latrice Hayes Jan 2023

The Relative Impact Of Transformational Leadership On The Academic Optimism Of High Poverty Urban Elementary Schools In Alabama, Cheritta Latrice Hayes

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THE RELATIVE IMPACT OF TRANSFORMATIONAL LEADERSHIP ON THE ACADEMIC OPTIMISM OF URBAN ELEMENTARY SCHOOLS IN ALABAMA In an era of accountability, educational leaders seek and implement reform efforts to help promote school improvement and student achievement on a regular basis (Marzano et al., 2014). When considering school improvement, a possible strategy to increase student achievement could be the relationship between the school leadership style and the characteristics of the organization that are within the control of the school leader. The purpose of this study was to examine the relative impact of transformational leadership on the academic optimism of schools. Elementary …

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Transdiagnostic Symptom Clusters Among Idiopathic Pain And Fatigue Disorders, Chloe Lisette Jones Jan 2023

Transdiagnostic Symptom Clusters Among Idiopathic Pain And Fatigue Disorders, Chloe Lisette Jones

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Background: There are no established etiologies, biomarkers, or approved treatments for myalgicencephalomyelitis/chronic fatigue syndrome (ME/CFS). It is thought that the ME/CFS criteria may be diagnosing individuals within a spectrum of different disease states, or even different diseases. There likely exist shared mechanisms across idiopathic pain and fatigue disorders, and diverse mechanisms underneath each individual diagnosis. The need to compare ME/CFS to similar, overlapping, and distinct disorders is a critical element in progressing our understanding of idiopathic pain and fatigue. Methods: A total of 2,731 comprehensive medical history and symptom reports were collected from respondents across the globe with a variety …

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