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Association Of Abdominal Obesity And Risk Of Atrial Fibrillation: Findings From The Reasons For Geographic And Racial Differences In Stroke (Regards) Study, Joonseok Kim Jan 2021

Association Of Abdominal Obesity And Risk Of Atrial Fibrillation: Findings From The Reasons For Geographic And Racial Differences In Stroke (Regards) Study, Joonseok Kim

All ETDs from UAB

Background: Our knowledge of the association between abdominal obesity (AO) and the risk of atrial fibrillation (AF) after adjusting for body mass index (BMI) is limited. Methods: We included 11,617 black and white participants (mean age 63.0 + 8.4 years) from the REGARDS (REasons for Geographic and Racial Differences in Stroke) national cohort study who were free of AF at baseline between 2003 and 2007, and completed a follow-up exam between 2013 and 2016 with assessment of AF. A multivariable logistic regression model was used to estimate the odds ratio (OR) with 95% confidence interval of incident AF associated with …

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Risk Of Delirium With Opioid Use Among Older Adults In The Emergency Department, Rachel Michelle Skains Jan 2021

Risk Of Delirium With Opioid Use Among Older Adults In The Emergency Department, Rachel Michelle Skains

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Objectives: Delirium affects 7-17% of older Emergency Department (ED) patients. Inadequate pain control and opioid pain management have been reported to increase risk for delirium. The aim of this study was to evaluate the association between pain severity, opioid exposure, and delirium among older ED patients.Methods: A single-center retrospective cohort study was conducted in an academic Geriatric ED. Patients aged ≥65 years with an Identification of Seniors at Risk (ISAR) score ≥2 and an Emergency Severity Index (ESI) level 3 were enrolled into the Geriatric ED Pathway. Those who received a delirium screening using the Nursing Delirium Screening Scale (NuDESC) …

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Influence Of Race, Gender, Rurality, And Dyadic Health On Symptom Pattern Trajectories In Persons With Advanced Heart Failure, Macy Lynn Stockdill Jan 2021

Influence Of Race, Gender, Rurality, And Dyadic Health On Symptom Pattern Trajectories In Persons With Advanced Heart Failure, Macy Lynn Stockdill

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Individuals living with heart failure experience a high symptom burden that must be addressed to improve their quality of life as well as the quality of life of their family caregivers. This is a challenging task as different situational and individual factors, including clinical/physiological factors and cultural factors, can affect an individual’s symptom experience. The purpose of this dissertation study was to examine existing symptom pattern trajectories and associated factors (sociodemographic, clinical/physiological characteristics, dyadic health) among a sample of under-resourced and racially diverse older adults with advanced heart failure living in the Deep South. This purpose was accomplished through four …

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Attitudes, Beliefs, And Perceived Self-Efficacy Pre- And Post- Suicide Prevention Training, Angela Marie Sullivan Jan 2021

Attitudes, Beliefs, And Perceived Self-Efficacy Pre- And Post- Suicide Prevention Training, Angela Marie Sullivan

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A 2017 World Health Organization (WHO) data brief included suicide in the top 20 causes of death worldwide. The WHO also listed suicide as the second leading cause of death for those aged 15 – 29 worldwide. In the US, suicide is the leading cause of violent death and has been consistently ranked as the 10th leading cause of death among all age groups in the US since 2008. In Alabama, the CDC reports suicide as the 11th leading cause of death in the state and the second leading cause of death for those aged 15 – 34. This study …

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Developing A Core Set Of Nursing-Sensitive Indicators For International Pediatric Oncology Nursing Practice, Courtney Erin Sullivan Jan 2021

Developing A Core Set Of Nursing-Sensitive Indicators For International Pediatric Oncology Nursing Practice, Courtney Erin Sullivan

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Although nursing sensitive indicators (NSIs) have been developed to measure factors influencing nursing care quality and patient outcomes in general and in select specialty areas, a core set of NSIs for international pediatric oncology nursing practice does not exist. Quality nursing care delivery in pediatric oncology is essential to achieving optimal patient outcomes and closing the 50% survival gap between high-income and low- and middle-income countries. To enhance global childhood cancer outcomes influenced by nursing, this dissertation research was conducted with the purpose of developing a preliminary core set of NSIs for international pediatric oncology nursing that is important, actionable, …

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An Evaluation Of The Impact Of Medical Home Structures And Care Processes On Temporary Profile Days Among Active-Duty U.S. Army Soldiers, Tanekkia M. Taylor-Clark Jan 2021

An Evaluation Of The Impact Of Medical Home Structures And Care Processes On Temporary Profile Days Among Active-Duty U.S. Army Soldiers, Tanekkia M. Taylor-Clark

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Readiness, the Armed Forces’ ability to carry out a range of military operations, is one of the U.S. Army’s highest strategic priorities. The medical readiness of soldiers is a critical component of overall operational readiness. The greatest threat to medical readiness is acute musculoskeletal injuries (MSIs). Medical providers place soldiers on medical limitations referred to as a “temporary profile” to facilitate treatment and recovery of acute MSIs. Poorly managed temporary profiles negatively impact soldiers’ work attendance and performance, leading to the loss or limitation of over 25 million training/duty days annually. Changes within the primary care setting, including implementing the …

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Is There A Relationship Between Leadership Characteristics And Services Provided Among Ihs Urban Indian Health Programs?, George Grant Tribble Jan 2021

Is There A Relationship Between Leadership Characteristics And Services Provided Among Ihs Urban Indian Health Programs?, George Grant Tribble

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IS THERE A RELATIONSHIP BETWEEN LEADERSHIP CHARACTERISTICS AND SERVICES PROVIDED AMONG IHS URBAN INDIAN HEALTH PROGRAMS?GEORGE G. TRIBBLE HEALTHCARE LEADERSHIP ABSTRACT The Native American population has faced and been impacted by a wide range of actions throughout the last few hundred years. The loss of cultural norms and way of life continues to manifest itself through various socioeconomic concerns. At the center of the Native American leadership model is a disciplined and culturally specific guidance structure. The Urban Indian Health Program (UIHP) was created by the Indian Health Service to establish a culturally appropriate health care delivery model for Native …

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The Relationships Fathers Have With Their Co-Residential Adult Children With Developmental Disabilities: A Qualitative Exploration Of Fatherhood And Masculinity, Kirsten Leigh Ostergren Clark Jan 2021

The Relationships Fathers Have With Their Co-Residential Adult Children With Developmental Disabilities: A Qualitative Exploration Of Fatherhood And Masculinity, Kirsten Leigh Ostergren Clark

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This dissertation explored the relationships between fathers and their co-residential adult children who have been diagnosed with an intellectual and developmental disability (IDD). This research addressed 1) the ways fathers understand their involvement in the lives of their adult child with developmental disabilities, especially as it relates to their masculinity; 2) how fathers perceive that their experiences fathering their child have impacted their health and health behaviors, including how masculinity plays a part; and 3) what supports fathers stated they have utilized and recommend, along with what challenges and constraints fathers feel they have faced. My analysis of in-depth interviews …

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Disrupting The Perioperative Opioid Gateway: Identification Of Risk Factors For New Persistent Post-Surgical Opioid Use, Gia Marie Pittet Jan 2021

Disrupting The Perioperative Opioid Gateway: Identification Of Risk Factors For New Persistent Post-Surgical Opioid Use, Gia Marie Pittet

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A large portion of the American Opioid Crisis is due to opioid naïve patients who become new persistent post-surgical opioid users, although the risk factors for the development of this addiction are not well studied. The objective of this study was to analyze multiple layers of pre-operative and procedural risk factors using an ecological perspective theoretical framework in adult patients undergoing invasive surgery. We performed a retrospective analysis of 13,970 opioid naïve adults in a mixed surgical cohort with data available at the University of California Los Angeles that was merged with narcotics data for the State of California (IRB#19-000625). …

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Development And Evaluation Of A Functional Human Cardiac Tissue Equivalent Fabricated From Multi-Lineage Human Induced Pluripotent Stem Cell Derived Cells, Danielle Pretorius Jan 2021

Development And Evaluation Of A Functional Human Cardiac Tissue Equivalent Fabricated From Multi-Lineage Human Induced Pluripotent Stem Cell Derived Cells, Danielle Pretorius

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The human heart is an exceptionally complex muscular organ that is vital for survival. Electrical impulses signal activation of mechanical contractions, pumping blood through the entire body and allowing for oxygen-exchange to occur. Unfortunately, certain disease states or traumatic injuries such as myocardial infarctions hamper the heart’s efficiency and function by damaging its structure. Ideal treatment would allow for the replacement or regeneration of the damaged tissue with cells and material harvested from the patient, thus avoiding the potential for immune rejection. Engineered cardiac tissues fabricated from human induced pluripotent stem cells have shown great promise for restoring function in …

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Inflammation, Executive Function, And Adiposity In Children With Or At Risk For Obesity, Kathryn L. Prendergast Jan 2021

Inflammation, Executive Function, And Adiposity In Children With Or At Risk For Obesity, Kathryn L. Prendergast

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Obesity is associated with executive function (EF) deficits across the lifespan. Higher body mass index (BMI), greater severity of obesity, and poorer adherence and weight outcomes in obesity treatment have all been associated with EF deficits. Adult literature has begun to emphasize neuroinflammation in obesity as a possible pathway to later cognitive impairment. However, the pediatric obesity literature has yet to even establish associations between peripheral inflammation and EF. Thus, the present study aimed to examine associations and variability in inflammatory biomarkers, EF, and adiposity in children with or at risk for obesity. Additionally, inflammation was examined as a mechanism …

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Biomarker And Target Discovery In Cancer, Alyncia Dominique Robinson Jan 2021

Biomarker And Target Discovery In Cancer, Alyncia Dominique Robinson

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Cancer is a complex disease characterized by uncontrolled growth of transformed cells that can arise in many tissue types throughout the body (e.g., breast, lung, prostate, pancreas, lymph nodes) and is a major cause of death worldwide. Cancer progression resulting in aggressive or metastatic disease accounts for one of the leading causes of death worldwide, second only to heart disease in the US. Incidentally, cancer-related mortality has been on a steady decline, dropping 25% over the last 25 years [1]. This could be attributed to improved and earlier diagnoses and better treatment options being developed over the past few decades. …

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Urban School Leaders’ Perceptions Of Community Education Within Essentialist Educational Policy Contexts, Ashley Samuels Jan 2021

Urban School Leaders’ Perceptions Of Community Education Within Essentialist Educational Policy Contexts, Ashley Samuels

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Urban schools face the enormous task of providing a wide range of support to students. These supports include academics, socio-emotional learning, health, nourishment, and even clothing. Students arrive with challenges that make it difficult to concentrate on their academic studies. The community education model can supply students in urban schools with needed resources so that they may prioritize their academics. A community education model is a holistic approach to providing support to students. With this in mind, the urban school leader must find a way to provide comprehensive support to students, both through community education and in consideration of essentialist …

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Applications Of Longitudinal Machine Learning Methods In Multi-Study Alzheimer's Disease Datasets, Charles F. Murchison Jan 2021

Applications Of Longitudinal Machine Learning Methods In Multi-Study Alzheimer's Disease Datasets, Charles F. Murchison

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Advances in statistical learning models for prediction have led to broader application across a variety of disciplines, granting generalizations and adaptations that were previ-ously intractable even with advanced computational techniques. Among these is the al-lowance of correlated data with inherent paneled structure such as longitudinal or clus-tered data; adjustments which have already begun to be applied to a variety of supervised and unsupervised machine learning methods which had previously focused on cross-sec-tional data. These modifications have seen rudimentary testing in a number of applied disciplines where correlated data is commonly observed, including medical and clinical research. One field in particular …

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Neonatal Murine Cytomegalovirus Infection Disrupts Synapse Remodeling During Development, Jerome Moulden Jan 2021

Neonatal Murine Cytomegalovirus Infection Disrupts Synapse Remodeling During Development, Jerome Moulden

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Human cytomegalovirus (HCMV) is a complex double stranded DNA betaherpesvirus. Its linear DNA in enclosed in an icosahedral capsid, and has a genome size of about 230kb and encodes about 170 genes. Primary infection with HCMV lead to a lifelong persistent infection. HCMV can also be transmitted across the placenta and infect the developing fetus leading to infection of the newborn infant, an infection which is commonly described as congenital HCMV infection. In the United States, the prevalence of congenital HCMV infection is between 0.2-1.2%. Approximately 5-15% of these newborn infants will develop long-term neurological damage resulting, motor disorder, cognition …

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Identifying Factors To Inform The Development Of Adaptive Interventions For Increasing Physical Activity Behavior Among People With Multiple Schlerosis, Yumi Kim Jan 2021

Identifying Factors To Inform The Development Of Adaptive Interventions For Increasing Physical Activity Behavior Among People With Multiple Schlerosis, Yumi Kim

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People with multiple sclerosis (MS) can benefit from physical activity, specifically exercise, for the management of disease symptoms, including walking impairments, fatigue, and depression, and improvements in quality of life. However, people with MS do not engage in adequate amounts of physical activity for the accrual of health benefits. Researchers have focused on the delivery of exercise training and behavioral interventions to improve levels of physical activity in MS. To date, there is an emerging body of research supporting the efficacy of these interventions for increasing and potentially sustaining physical activity behavior in people with MS. Yet, people with MS …

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Multidrug-Resistance, Antibiotic-Associated Acute Kidney Injury, And Poor Disease Prognosis In Community-Acquired Bacterial Pneumonia, Adeniyi J. Idigo Jan 2021

Multidrug-Resistance, Antibiotic-Associated Acute Kidney Injury, And Poor Disease Prognosis In Community-Acquired Bacterial Pneumonia, Adeniyi J. Idigo

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In this dissertation research, I examined the challenges of treating patients with bacterial community-acquired pneumonia (CAP) with the purpose of identifying risk factors linked with multidrug-resistant (MDR) Pseudomonas, treatment toxicity, and poor disease prognosis. I used a retrospective cohort study design to explore a clinical cohort of patients admitted to the University of Alabama at Birmingham hospital network who had bacterial pneumonia diagnosis assessed to be from community transmission between January 2013-December 2019. Electronic medical records were accessed for socio-demographic and clinical information. First, I examined the local prevalence/incidence of Pseudomonas CAP and MDR Pseudomonas CAP, and the relationship between …

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Studies On Nontypeable Haemophilus Influenzae Biofilm Persistence & Redox Homeostasis In Chronic Bacterial Diseases, Benjamin C. Hunt Jan 2021

Studies On Nontypeable Haemophilus Influenzae Biofilm Persistence & Redox Homeostasis In Chronic Bacterial Diseases, Benjamin C. Hunt

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Bacterial biofilms, or surface-adherent bacterial communities surrounded by a self-produced extracellular polymeric matrix, are ubiquitous. They are found throughout Earth’s ecosystems, in the soil and waterways, and more pressingly for the medical community, they are found within humans. Bacterial biofilms are associated with a multitude of diseases and their involvement significantly complicates treatment given that bacteria growing within a biofilm are extremely more resistant to antibiotics and immune effectors. Thus, the need to better understand biofilm biology and find ways to disrupt and/or sensitize biofilms to medical treatment is significant. The goal of the research presented herein was to investigate …

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Tau-Sh3 Interactions And Alzheimer's Disease, Jonathan Roth Jan 2021

Tau-Sh3 Interactions And Alzheimer's Disease, Jonathan Roth

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Alzheimer’s disease (AD) is the most common neurodegenerative disorder worldwide, and its impact will increase with an aging population. It is characterized by dementia associated with accumulation of extracellular amyloid-β (Aβ) plaques, intracellular hyperphosphorylated Tau tangles, and neurodegeneration. Additionally, network hyperexcitability occurs early in AD and likely contributes to disease pathogenesis. Current therapies provide minor delay of disease progression at best, so it is imperative to develop novel therapeutic approaches to prevent and treat AD. As Tau pathology correlates better with cognitive function than Aβ pathology and Tau reduction prevents Aβ-induced dysfunction in preclinical models, targeting Tau is a growing …

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Functions Of Drosophila Hp1 Proteins In Transcriptional Regulation, John Schoelz Jan 2021

Functions Of Drosophila Hp1 Proteins In Transcriptional Regulation, John Schoelz

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The Heterochromatin Protein 1 (HP1) family are a group of non-histone chromosomal proteins with functions in many essential DNA processes. The HP1 family is highly conserved, and many eukaryotic genomes contain multiple HP1 genes. Individual paralogs specialize in specific functions, although they do have overlapping roles in some processes. In Drosophila, there are three HP1 paralogs expressed in somatic cells: HP1a, HP1B and HP1C. All three of these proteins have previously been implicated in both the positive and negative regulation of transcription. Furthermore, the three proteins share binding sites and colocalize broadly throughout the Drosophila genome. Here, we investigate individual …

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Effeccts Of Hiv-1 Tat On Tspo, A Biomarker Of Neuroinflammation, Nguyen Thuy Nhu Nguyen Jan 2021

Effeccts Of Hiv-1 Tat On Tspo, A Biomarker Of Neuroinflammation, Nguyen Thuy Nhu Nguyen

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HIV-associated neurocognitive disorders (HAND) produces serious neurological dysfunction for > 50% of people living with HIV (PLWH). As antiretroviral therapy (ART) has transformed HIV into a chronic disease, and since most ART does not effectively cross the blood brain barrier, HAND is predicted to further increase in prevalence in PLWH. The HIV-Trans-Activator of Transcription (Tat) is known to persist in the central nervous system (CNS) of chronically infected HIV+ individuals. In several preclinical studies, HIV-Tat has been shown to be neurotoxic and important for HIV pathogenesis. Translocator protein (TSPO), an 18 kDa mitochondrial protein, has been shown to be increased via …

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Characterization Of Rna Polymerase I Trigger Loop Mutations, Collin Ainslie Jan 2021

Characterization Of Rna Polymerase I Trigger Loop Mutations, Collin Ainslie

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RNA polymerases are primarily multi-subunit enzymes that synthesize RNAs from template DNA strands. RNA polymerase I (Pol I) is the eukaryotic RNA polymerase that synthesizes the majority of ribosomal RNA (rRNA) for ribosome production. These include the 5.8S, 28S, and 18S rRNAs which are synthesized from a polycistronic gene in the nucleolus. The rRNAs synthesized by Pol I, the 5S rRNA, & ribosomal proteins come together to synthesize ribosomes through ribosome biogenesis. Dysregulation of Pol I activity has been established to contribute to dysregulation of ribosome biogenesis and disease state development. These conditions include but are not limited to Cincinnati …

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A Stress Process Approach To Assessing Caregiver Burden, Depressive Symptoms, And Quality Of Life: The Role Of Attachment In Adult Relationships, Ghislaine Celine Atkins Jan 2021

A Stress Process Approach To Assessing Caregiver Burden, Depressive Symptoms, And Quality Of Life: The Role Of Attachment In Adult Relationships, Ghislaine Celine Atkins

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Aging adults (65 years and older) are projected to be the largest age group in the United States by around the year 2030. Importantly, the population of aging adults is expected to outnumber their adult children for the first time by the year 2033. The extant literature posits that the majority of carer-care-recipient relationships are between adult children/in law and their aging parent or a spouse/partner. Familial carers dealing with these multiple stressors are more likely to exhibit depressive symptoms, have higher appraisals of stress and have worse quality of life. This dissertation project utilized sociologist Pearlin’s Stress Process Model …

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Characterization Of Cellular And Viral Factors That Define The Stability Of The Latent Hiv-1 Reservoir, Eric Carlin Jan 2021

Characterization Of Cellular And Viral Factors That Define The Stability Of The Latent Hiv-1 Reservoir, Eric Carlin

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Human immunodeficiency virus (HIV) infection is a chronic viral illness that requires lifelong management due to the early formation of a latent viral reservoir within the patient’s CD4+ T cells. These latent infection events lay dormant within infected cells and reactivate stochastically or during periods of T cell activation presenting a major hurdle to the development of an HIV cure. As our understanding of the factors that contribute to HIV latency has evolved, we have started to appreciate latency as more than a chromatin regulation phenotype, due to the vast number of cellular factors that have been described to impact …

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Evaluation Of The Effectiveness Of Rotc Army Cadet Exercise Training For The Army Combat Fitness Test, Simone Cannon Jan 2021

Evaluation Of The Effectiveness Of Rotc Army Cadet Exercise Training For The Army Combat Fitness Test, Simone Cannon

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To see the effectiveness of a twelve-week exercise training program in relation to ACFT performance over time. With changes to the Army’s standard physical test, the Army believes the ACFT will better prepare soldiers for combat. Physical Training is required and compared to the ACFT done by Army ROTC cadets for training purposes. Participants of this study were a part of the UAB ROTC program ranging from freshman to seniors. Height, weight, and body composition measurements were taken. Over twelve weeks, participants trained three days per week (MWF) at the ROTC building and executed the training protocol for one hour …

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Tgfβ Provides The Backbone Of Embryogenesis: Elucidating The Role Of Tgfβ Signaling And Its Downstream Effectors On Spinal Column Development, Sade Williams Clayton Jan 2021

Tgfβ Provides The Backbone Of Embryogenesis: Elucidating The Role Of Tgfβ Signaling And Its Downstream Effectors On Spinal Column Development, Sade Williams Clayton

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The spinal column is composed of two components, the vertebra (VB) that provide support and the intervertebral disc (IVD) that provide weight distribution. The structural integrity of IVDs is maintained by a fibrocartilaginous tissue called the annulus fibrosus (AF) which can degenerate with age or trauma and contribute to chronic back pain. There are currently no diseases modifying treatments that curb IVD degeneration. Regenerative therapies to treat IVD degeneration can be developed from identifying the signaling factors required for AF differentiation, but these factors are unknown. Previously, we showed that TGFβ signaling is required for AF formation in mice and …

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Model Invariant Visual Tracking Using Deep Learning Of Trajectories, Pravinkumar G. Kandhare Jan 2021

Model Invariant Visual Tracking Using Deep Learning Of Trajectories, Pravinkumar G. Kandhare

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A target tracking is a well-known computer vision problem due to its wide range of applications in industrial and biomedical domains, such as traffic planning and management, surveillance, robotics, economics, human-computer interaction prediction, and electrode tracking for surgical planning. A significant amount of research has been done to tackle the problem. However, it is still challenging to design a robust tracking system that can provide solutions for many real-world tracking applications and prediction. Most of the proposed tracking solutions are complex due to many model parameters. The overarching goal of this dissertation is to develop predictors and trackers that would …

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Combining Meg And Fmri To Examine Dynamic Task-Related Brain Activity With High Spatio-Temporal Resolution, Sangeeta Nair Jan 2021

Combining Meg And Fmri To Examine Dynamic Task-Related Brain Activity With High Spatio-Temporal Resolution, Sangeeta Nair

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The characterization of brain networks contributing to healthy learning and memory can inform abnormalities and treatment approaches among clinical populations. A recent shift from lesion-based to network-based approaches of studying healthy and atypical brain development highlights the need for a more comprehensive understanding across spatiotemporal domains, particularly in the case of high-level cognitive processes. Both, associative learning and working memory involve distributed and interconnected networks of specialized brain regions. Dynamic communication within- and betweensuch systems are unable to be fully resolved by individual non-invasive imaging techniques such as fMRI or MEG. While fMRI serves as an ideal tool to investigate …

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Hurricanes And Heart Problems: Natural Disaster, Social Capital, And Cardiovascular Mortality, Zachary H. Mccann Jan 2021

Hurricanes And Heart Problems: Natural Disaster, Social Capital, And Cardiovascular Mortality, Zachary H. Mccann

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Social capital refers to the social relationships and structures that provide individuals with material, financial, and emotional resources throughout their lives. Previous research has found an association between high levels of social capital and lower rates of all-cause and cardiovascular disease (CVD) mortality. Severe disasters have been linked to higher rates of all-cause and CVD mortality. In post-disaster settings social capital may be a valuable resource for protecting against both forms of mortality. Past research shows that social capital can improve access to resources, such as food, water, and medical supplies, that reduce all-cause and CVD mortality. Using previous research …

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A Role For Inf-Ɣ-Inducble Transcription Factors In Antibody Secreting Cell Differentiation, Jessica N. Peel Jan 2021

A Role For Inf-Ɣ-Inducble Transcription Factors In Antibody Secreting Cell Differentiation, Jessica N. Peel

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Viral infections remain a major cause of morbidity and mortality. Within a viral, interferon (IFN)-ɣ-driven inflammatory microenvironment, B cells may produce antibody which is critical for rapid viral clearance and continued protection from reinfection. However, the roles of IFN-ɣ and IFN-ɣ-induced transcription factors (TFs) in driving antibody secreting cell (ASC) development from their B cell precursors are poorly understood. Herein, we identify two IFN-ɣ-inducible transcription factors (TFs), T-bet and interferon regulatory factor 1 (IRF1), that are essential for the differentiation of ASCs from IFN-g-activated B cell precursors. T-bet repressed an IFN-ɣ-inducible inflammatory gene program that was incompatible with ASC formation …

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