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User Acceptance Of Deskab Mobile Application For Early Detection Of Scabies In Indonesia, Sandra Widaty, Dewi Friska, Kusmarinah Bramono, Siti Maulidya Sari, Irene Darmawan, Aria Kekalih

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Individual case management strategy is not suitable for reducing scabies transmission, especially in high prevalence settings. A community-based approach has been proposed to control scabies. We developed a mobile application, called DeSkab, to empower non-medical personnel in crowded populations e.g., boarding schools, and to aid the identification of skin lesions suggesting scabies based on the cardinal signs of scabies. Early treatment and prevention of scabies transmission is expected to follow this approach. This was the initial development of the DeSkab mobile application which aims to assess user acceptance.

Methods: The DeSkab mobile application was designed using Java …

Histoid Leprosy Mimicking Lichen Planus, Kesya Kimberly, Annisa Alviariza, Siti Aisha Nabila Ferina, Prima Kartika Esti, Lenti Br. Peranginangin, Eka Komarasari

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Histoid leprosy is a rare variant of lepromatous leprosy (LL), characterized by unique clinical, histopathological, and microbiological features. This type of leprosy is caused by multidrug therapy (MDT) drug resistance, train mutation of Mycobacterium leprae, or genetic factors.

Case Illustration: A 21-year-old Indonesian woman with a family history of histoid leprosy complained of multiple hypo-esthetic erythematous partly flat-topped papules around the lesion on the face and bilateral superior and inferior extremities for the last two years. A Slit-skin smear examination revealed acid-fast bacilli with a bacterial index (BI) of 4.17+ and morphological index (MI) of 1%. Histopathological …

Situation Analysis Of Health Problems In Depok City In 2021, Murti Utami Putri, Asri C. Adisasmita, Hidayat Nuh Ghazali Djajuli

Jurnal Epidemiologi Kesehatan Indonesia

Based on 2021 data, from the results of problem identification, 16 health problems in Depok City were assessed. Maternal mortality was selected as a priority problem with 65 cases of maternal death or 155.58 per 100,000 live births. COVID-19 infection is the most common cause of maternal death. This study aims to provide an overview of maternal death circumstances in Depok because of prioritization following situation analysis of health problems. This situation analysis was conducted in Depok with a quantitative and qualitative approach analyzed using the PAHO-adapted Hanlon involving the participation of 17 respondents from the Health Office and the …

Effect Of Triple Antibiotic Paste, Double Antibiotic Paste, And Calcium Hydroxide On Antibiotic Resistance Of Tet Repressor Proteins, Tetracycline Resistance Gene W, And Tetracycline Resistance Gene Q: A Randomized Controlled Clinical Trial, Ertuğrul Karataş, Özgen Kırmızıbekmez, Mustafa Özkan Baltacı, Ahmet Adıgüzel

Journal of Dentistry Indonesia

Objective: To investigate the effect of the use of Calcium Hydroxide (Ca(OH)2), Triple Antibiotic Paste (TAP), and Double Antibiotic Paste (DAP) as intra-canal medicaments on the development of antibiotic resistance by evaluating tetracycline genes. Methods: Forty five patients were randomly assigned into 3 groups according to the intracanal medication using a web program (www.randomizer.org), (Ca(OH)2, TAP and DAP). Root canal bacteriological samples were collected before root canal treatment (S1) and after chemo-mechanical procedures (S2). Following root canal shaping procedures, intra-canal medication of the root canals was performed with selected intra-canal medicament. A second appointment was planned for the …

Enigmatic Cervicofacial Actinomycosis Post Radiotherapy - A Case Report, Amanda Phoon Nguyen

Journal of Dentistry Indonesia

Although thought to be uncommon, it is believed that cervicofacial actinomycosis is underreported due to frequent misdiagnosis. It has been called the “most misdiagnosed disease by experienced clinicians”. A wide range of dental procedures or trauma, including tooth eruption, may precipitate actinomycosis by enabling microorganisms to penetrate the deeper tissue layers via an entry point. This infective disease is significant due to its potentially aggressive and locally destructive nature. This case describes a patient diagnosed with cervicofacial actinomycosis. Her history prior to this was significant for proliferative verrucous leukoplakia, and T4aN0M0 (AJCC 7th Edition) squamous cell carcinoma of the right …

Willingness Of Graduate Nursing Students To Provide Care For Covid-19 Patients, Andrea Beatrice Josef, Hannah Grace Pascual, Antonette Mei Surigao, Jemina E. Fuentebella, Kathyrine Calong Calong, Gil P. Soriano, Carrisa Juliana Balaria, Ryan Michael F. Oducado

Jurnal Keperawatan Indonesia

Nurses play a key role in management and care services to maintain patient safety; however, with the emergence of COVID-19, the number of nurses still continues to decline. Due to the on-going problem that even novice nurses may see as a major challenge, this study aims to identify whether nursing graduates are willing to participate in the care of COVID- 19 patients. The study is cross-sectional where a total of 146 conveniently chosen nursing graduates currently enrolled in Nursing Review Centers in the Philippines preparing to take the Nurse Licensure Examination. The data were collected using Google forms from August …

Evaluation Of Solid Medical Waste Management In Bogor Regional Public Hospitals, Silvia Khansa, Agustin Kusumayati, Dewi Susanna, Uli Tiarma Sinaga

Kesmas

Healthcare facilities generate medical waste. If not properly managed, medical waste may damage the environment and spread diseases. Many hospitals in Indonesia do not adhere to medical waste management regulations. This study aimed to evaluate the management of solid medical waste at four public hospitals in Bogor District, Indonesia. A case study design was used to obtain a comprehensive description of the solid medical waste management activities inthe hospitals. Data were collected through direct observations, interviews, and document reviews. This study revealed that the medical waste generated in allhospitals was infectious, pathological, pharmaceutical, chemical, and cytotoxic, totaling approximately 4,000-12,000 kg. …

Development Of An Evidence-Based Tool To Assess The Relative Vulnerability Of Different Communities To Tuberculosis, Slamet Isworo, Sri Handayani, Reece Hinchcliff, Zainal Arifin Hasibuan

Kesmas

Identifying specific tuberculosis (TB) vulnerabilities in populations based on their geographical, demographic, and epidemiological characteristics is anessential yet challenging requirement to help reduce and eliminate TB. Assessment tools that can accurately quantify the risks associated with key factorscould be used to measure TB vulnerability efficiently and indicate the most appropriate range of interventions. This study aimed to develop TB vulnerability assessment tools based on a TB vulnerability assessment conceptual framework developed with Leximancer. Three steps to produce the tools were facetanalysis, interpreting the facet to create a list of questions, and expert judgment to confirm the suitability of the questionnaire. …

Towards Digital Health Transformation: The Urgency Of Electronic Student Health Reports (Case Study In Sd Negeri Cipedak 03, South Jakarta And Puskesmas Jagakarsa), Retnowati Retnowati, Kemal N. Siregar, Dion Zein Nurizin, Arief Azhari Ilyas

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

The community health center (Puskesmas) routinely collects student health examination data in health report books, causing storage, monitoring, and analysis difficulties. This has led to suboptimal health interventions involving parents, schools, and Puskesmas. This research analyzes user needs in developing an electronic-based student health report. This qualitative descriptive study employs the Framework for the Application of System Thinking (FAST) approach. The research was conducted at the Puskesmas Jagakarsa and SD Negeri Cipedak 03, South Jakarta. The study findings indicate utilizing student health report books is not optimal. Based on the needs analysis, there is a necessity to develop an electronic-based …

Analisis Spasial Autokorelasi Tuberkulosis Di Pulau Jawa Tahun 2021, Nayaka Nayottama Pamadi, Kemal N. Siregar, Martya Rahmaniati, Atmiroseva Atmiroseva

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Tuberkulosis (TB) adalah salah satu penyakit menular yang masih menjadi masalah kesehatan masyarakat di Indonesia. Terlebih, adanya pandemi COVID-19 berimbas kepada berkurangnya progress dan penanganan TB di tahun 2021, maka dari itu dilakukan penelitian untuk mengetahui situasi TB dan melihat hubungan spasial pada kasus TB dengan faktor-faktor risikonya di salah satu wilayah dengan jumlah kasus tertinggi di Indonesia; Pulau Jawa, di tingkat kabupaten/kota. Faktor risiko dibagi menjadi dua kelompok, yaitu faktor geografis seperti rata-rata ketinggian, suhu tahunan, dan kelembaban tahunan; serta faktor sosiodemografi yang mencakup kepadatan penduduk/densitas, jumlah fasilitas kesehatan, dan rata-rata usia diagnosis. Hasil penelitian menunjukkan adanya pola mengelompok …

Identifikasi Faktor-Faktor Yang Mempengaruhi Penurunan Fungsi Paru Masyarakat Di Sekitar Pembangkit Listrik Tenaga Uap, Fajaria Nurcandra, Terry Yuliana Rahadia Pristya, Azizah Musliha Fitri

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Penyebab utama kelainan fungsi paru adalah kebiasaan merokok dan diperburuk oleh faktor lain seperti polusi udara dan paparan bahan kimia. Residu dari aktivitas pembangkit listrik tenaga uap yang salah satu bahan bakarnya batubara dapat menurunkan kesehatan paru-paru dalam jangka panjang atau menyebabkan penyakit karsinogenik kronis. Abu terbang sebagai residu berpotensi terlepas ke udara dalam jumlah yang dapat terhirup dan beracun. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang mempengaruhi kondisi paru-paru warga sekitar PLTU X. Penelitian cross-sectional dilakukan pada 146 orang yang dipilih menggunakan purposive sampling dan tinggal di sekitar PLTU X. COPD Assessment Test (CAT) dan kuesioner mMRC digunakan untuk …

Personality And The Intention To Use Bus Rapid Transit On Pandemic Covid-19: The Role Of Environmental Concern As A Mediator, Muhammad Abdan Shadiqi

Psychological Research on Urban Society

The COVID-19 pandemic has had an impact on the behavior of public transport users and raised concerns about the means of transportation. Therefore, this study aims to explain the mediating effect of environmental concern in the relationship between five personality traits on the intention to use Bus Rapid Transit (BRT) during the pandemic. A correlational survey of 425 participants was conducted, and the analysis found that all five personality traits did not directly predict the intention to use BRT. Furthermore, there was a positive mediating effect at the weak level of environmental concern on the relationship between four of the …

Metabolomic Insights Into Tuberculosis: Machine Learning Approaches For Biomarker Identification, Miftahul Khair Akbar, Arief Aulia Rahman

Indonesian Journal of Medical Chemistry and Bioinformatics

The lung parenchyma is largely impacted by the infectious condition known as pulmonary tuberculosis (pulmonary TB) when the immune system creates a wall around the germs in the lungs, a tiny, hard bulge known as a tubercle develops, earning the disease the name tuberculosis. Although the majority of TB germs target the lungs, they can also harm other bodily organs. The identification of TB biomarkers, which are crucial for diagnosis, treatment monitoring, risk analysis, and prognosis, has been the subject of extensive research. Differences in metabolites between normal cells and tuberculosis are considered to be able to support the diagnosis …

Manajemen Koinfeksi Malaria Berat Dengan Hiv Belum Mendapat Terapi Antiretrovirus Di Era Pandemi Covid-19: Sebuah Laporan Kasus, Paul Harijanto, Rosye Mawuntu, Novia Rusli, Randy Adiwinata, Agung Nugroho

Jurnal Penyakit Dalam Indonesia

Severe malaria is a serious infectious disease that required immediate diagnosis and prompt treatment. Severe malaria may result several organ failures which is similar with other infectious diseases like SARS-CoV-2, sepsis, dengue, and HIV infection. Most of those infection have similar symptoms such as fever, myalgia, and headache, therefore physician should have high suspicion regarding co-infection with other infectious agents. The overlapping symptoms of co-infections may become a challenge for physician in diagnosing and delivering prompt therapy. Failure to deliver prompt treatment may lead to fatal outcome such as in severe malaria case. Stigmatization of all patients with fever and …

Sensitive Intervention Policy Recommendations To Reduce Stunting Rates Based On Spatial Analysis Of Sanitary Factors In Dki Jakarta Province 2021, Septiria Irawati, Ema Hermawati

Journal of Indonesian Health Policy and Administration

The purpose of this study was to describe the prevalence of stunting in children under five and the percentage of proper sanitation, as well as recommendations for priority areas for stunting control interventions in the Province of the Special Capital Region of Jakarta in 2021. This study used a descriptive approach to present an overview of the percentage of sanitation and prevalence of stunting in children under five by sub-district in 38 districts in DKI Jakarta. Data is displayed as a map to show distribution areas based on high, medium, and low categories. An overlay was made between the distribution …

In-Silico Approach For Predicting The Inhibitory Effect Of Home Remedies On Severe Acute Respiratory Syndrome Coronavirus-2, Shankar Thapa, Mahalakshmi Suresha Biradar, Janmajoy Banerjee, Dipanjan Karati

Makara Journal of Science

Severe Acute Respiratory Syndrome Coronavirus-2 is an infectious disease caused by coronavirus and spreads through infected droplets inhalation. For the past 3 years, COVID-19 has become a global threat. Vaccinations are currently available and have FDA approval. During the recent pandemic, people adopted a psychological belief that home remedies (turmeric, ginger, garlic, and coriander) can prevent COVID-19. This research aimed to predict the covid-19 inhibitory activities by home remedies through an in-silico approach. The 24 bioactive constituents of four home remedies plants were downloaded from PubChem and subjected to molecular docking with the three important proteins responsible for COVID-19 pathogenesis. …

The Influence And Feasibility Of Therapeutic Exercise Videos At Home On The Functional Status Of Post-Covid-19 Hospitalization, Luh Karunia Wahyuni, Melinda Harini, Peggy Sunarjo, Mellisya Ramadhany, Ika Fitriana, Octaviany Hidemi, Indri Wijayanti, Boya Nugraha, Deddy Tedjasukmana, Tirza Z Tamin

Kesmas

The COVID-19 pandemic pushed physicians to modify conventional practices to reduce the exposure and risk of infection among patients and health workers. Telemedicine is one of the safest methods, and telerehabilitation could prevent the sequelae of COVID-19. A quasi-experimental study with randomized sampling without masking/blinding was conducted. The study was conducted from August 2021 to March 2022 at Hospital A in Pekanbaru, Hospital B in Jayapura, and Hospital C in Jakarta, Indonesia. A total of 27 patients were recruited and divided into control and intervention groups. The control group was given conventional education on therapeutic exercise at home, while the …

Oral Manifestations In Covid-19 Patients Associated With Oral Hygiene In Aceh, Indonesia: A Literature Review, Misra Hanum, Munifah Abdat, Nurjannah Nurjannah, Irwan Saputra, Said Usman

Kesmas

COVID-19 became a pandemic because of its high-speed transmission via salivary and airborne droplet routes. Viruses can enter host cells through ACE-2 receptors in various human organs, including the oral cavity. The oral manifestations that arise include white plaque, ulceration, burning sensation, oral mucositis, depapillation of the tongue, dry mouth, halitosis, and loss of the sense of taste. Poor oral hygiene, comorbidities, decreased immunity, and stress can exacerbate these manifestations. This review study aimed to report various oral manifestations of COVID-19 related to oral hygiene. Relevant articles were identified from PubMed, ScienceDirect, Elsevier, and Google Scholar. Out of the 60 …

Anxiety, Depression, Loneliness, Spirituality, And Social Support In Older People During The Covid-19 Pandemic, Esti Widiani, Nurul Hidayah, Abdul Hanan

Jurnal Keperawatan Indonesia

The COVID-19 pandemic has resulted in the threat of death. Some older people feel they are not ready to face the end of their lives, so psychosocial problems arise, such as loneliness, anxiety, and depression. This research study aims to explore some psychosocial aspects, namely spirituality, social support, depression, anxiety, and loneliness in the elderly during the pandemic. The research design was cross-sectional. The total sample was 142 people selected using the purposive sampling method. Data collection used various scales to look at spirituality, depression, anxiety, and loneliness. The results showed that median spirituality and social support scores were high. …

The Impact Of Stress On The Work Performance Of Covid-19 Isolation Room Nurses At Hospitals In Timor, Antonius Rino Vanchapo, Anggorowati Anggorowati, Ni Made Merlin

Jurnal Keperawatan Indonesia

The incidence of Corona Virus Disease (COVID-19) in East Nusa Tenggara has increased tremendously since April 2020. This has caused nurses to experience anxiety and stress due to fears of a shortage of special COVID-19 inpatient rooms. This study aimed to analyze the correlation between stress and the work performance of the COVID-19 isolation room nurses in mainland Timor. This cross-sectional study involved 278 nurses who worked in the COVID-19 isolation rooms of three hospitals on Timor Island. The Depression Anxiety Stress Scales (DASS-42) and the Nurse Work Performance Sheet were applied to obtain the data. The results demonstrated that …

The Climate Effect On Covid-19: Lessons Learned From The Pandemic In Jakarta, Vernonia Yora Saki, Ema Novita Deniati, Yoerdy Agusmal Saputra, Dewi Susanna, Efendi Efendi

Kesmas

The global COVID-19 pandemic has presented humanity with difficult and unforeseeable hurdles. Among these challenges is understanding how climate-related aspects impact the survival of the SARS-CoV-2 virus. This study aimed to investigate the relationship between environmental factors, such as temperature, humidity, and rainfall, and the spread of COVID-19 cases in different regions. A time-and-place-based ecological study design was adopted, integrating geographic information systems and statistical techniques. Statistical testing revealed a significant association between humidity (p-value = 0.000; r = -0.777) and rainfall (p-value = 0.001; r = -0.561) with COVID-19 instances. However, no statistically significant relationship was found between temperature …

Reshaping Healthcare: A Bibliometric Analysis Of Lessons Learned In Post-Covid-19 Health Policy, Azliyana Azizan, Khairul Hafezad Abdullah, Sri Ratna Rahayu, Nadia Safirah Rusli, Nornajehah Tarmidzi

Kesmas

The COVID-19 pandemic has profoundly impacted health policy globally, leading to heightened concern and urgency. However, previous studies have been hampered by limited resources and insufficient discussions on the long-term implications for health policies following multiple COVID-19 waves. Thus, this study examined the evolution of international studies on post-COVID-19 health policy. A comprehensive analysis used well-known literature databases Scopus and Web of Science to explore parameters including publication growth, participating countries, areas of interest, and keyword analysis of topics such as"COVID-19" and "Health Policy." The United States emerged as an active participant, focusing on "Computer science." Key themes included "COVID-19 …

Foreword From Handling Editor - 10th Edition, Ahyahudin Sodri

Journal of Environmental Science and Sustainable Development

We are delighted to present the 10th edition of JESSD, published in July 2023. We have selected twelve of the best articles for this edition that related with topic of Environmental Science and Sustainable Development.

Awareness Campaigns And Hand Hygiene Practice Among Secondary School Students, Rotimi Williams Olatunji, Noeem Thanny Taiwo

Journal of Environmental Science and Sustainable Development

Nigeria's low level of sanitation hygiene provoked the increasing prevalence and containment of infectious diseases such as bird flu, acute respiratory infections, Ebola, Lassa fever, polio, diarrheal, pneumonia, and dysentery. These diseases can attack vulnerable groups like children. Therefore, awareness of hand hygiene practices is still needed to prevent the spread of diseases. This study analyzed the exposure to campaign messages on hand washing and hand hygiene sanitation among secondary school students in Lagos State, Nigeria. A total of 620 students participated in the study and were selected through multi-stage sampling methods. Research instruments adopted included questionnaires and observation of …

Perubahan Perilaku Penggunaan Alat Pelindung Diri (Apd) Pasca Terinfeksi Covid-19 Pada Dokter Di Indonesia: Sebuah Survei Nasional Pada Awal Pandemi, Herikurniawan Herikurniawan, Evy Yunihastuti, Ari F. Syam, Dewi Sumaryani Sumaryani Soemarko, Andrian Wiraguna

Jurnal Penyakit Dalam Indonesia

Introduction. Doctors have greater risk of acquiring COVID-19 due to occupational exposure. Personal protective equipment (PPE) is an essential factor in reducing COVID-19 transmission. We aimed to evaluate the behavior changes of PPE usage among doctors in Indonesia before and after getting COVID-19 infection in early pandemic.

Methods. This was a descriptive online survey with cross-sectional design. This survey was conducted from October-December 2020 among Indonesian doctors who were COVID-19 survivors.

Results. A total of 389 doctors who survived COVID-19 infection across Indonesia were included in the final analysis. Most participants were general practitioners and residents (69.2%) with a median …

Kepatuhan Pengobatan Pada Pasien Tuberkulosis Dan Faktor-Faktor Yang Mempengaruhinya: Tinjauan Sistematis, Shania Adhanty, Syahrizal Syarif

Jurnal Epidemiologi Kesehatan Indonesia

Tuberkulosis (TB) merupakan penyakit menular yang disebabkan oleh bacillus mycobacterium tuberculosis. Ketidakpatuhan dalam pengobatan kerap menjadi masalah secara global, karena jika tidak mengikuti rangkaian pengobatan secara benar dapat menyebabkan resistensi obat, kambuhnya kembali penyakit, bahkan sampai kematian. Tujuan artikel ini adalah untuk mengetahui kepatuhan pengobatan pasien TB paru dan faktor-faktor yang mempengaruhinya pada studi observasional. Terdapat empat database (PubMed, Scopus, EMBASE dan MEDLINE) yang digunakan untuk menulusuri artikel. Kata kunci yang digunakan untuk pencarian diantaranya: (tuberculosis) OR (TB) AND (treatment adherence) OR (treatment compliance) OR (medication adherence) OR (medication compliance) AND (directly observed treatment shortcourse) OR (DOTS). Ditemukan sebanyak lima …

The Potential Of Economic Loss Due To Stunting In Indonesia, Esty Asriyana Suryana

Jurnal Ekonomi Kesehatan Indonesia

Stunting cases continue to increase, along with the high risk of undernutrition, the increasing prevalence of malnutrition, and decreasing productivity. If this condition is not handled correctly, it can affect Indonesia's development performance, inequality, and poverty. Stunting can hinder economic growth and labor productivity, affecting 11% of GDP (gross domestic product) and reducing the income of adult workers by up to 20%. Based on this, it is necessary to make prevention and control efforts in nutrition intervention activities an economic investment. Therefore, this study estimates the economic potential lost due to stunting in children under five. This descriptive study is …

Hubungan Stunting Dengan Anemia, Morbiditas Dan Perkembangan Anak Usia Batita Di Puskesmas Kebondalem Pemalang, Arwinda Nugraheni, Ani Margawati, Firdaus Wahyudi, Aras Utami

Jurnal Epidemiologi Kesehatan Indonesia

Kejadian stunting merupakan masalah kesehatan anak di Indonesia yang berdampak pada anemia, perkembangan dan sistem imunitas. Pada balita anemia, peningkatan morbiditas dan gangguan perkembangan dapat menyebabkan gangguan pada struktur dan fungsi tubuh dalam kemampuan anak menuju kematangan yang bersifat tetap dan berpengaruh pada kesehatan di masa mendatang. Penelitian ini bertujuan untuk mengetahui hubungan stunting dengan kadar hemoglobin, morbiditas dan perkembangan batita. Penelitian ini menggunakan desain penelitian cross-sectional dan dilakukan pada bulan Juli 2019 di wilayah kerja Puskesmas Kebondalem di Kabupaten Pemalang dengan sampel batita usia 6-26 bulan. Variabel penelitian yang dinilai adalah kadar hemoglobin (Hb), morbiditas, perkembangan yang diukur melalui …

Therapy Selection For Tinea Corporis And Cruris With Commorbidity: 3 Case Series, Yefta Yefta, Dwi Retno Adi Winarni, Agnes Sri Siswati

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Dermatophytosis is a superficial (skin, hair and nails) fungal infection caused by dermatophyte group fungi (Trichophyton, Epidermophyton and Microsporum). Immunocompromised conditions cause fungal infections to become more widespread and require consideration of therapy.

Case Illustration: This case series represented three cases of tinea corporis and tinea cruris in patients with comorbidities. The first case was tinea corporis and tinea cruris in a patient with congestive heart failure with oral terbinafine therapy. The second case was tinea corporis and tinea cruris in a patient with bilateral fourth degree hydronephrosis with oral griseofulvin therapy. The third case was tinea …

Analisis Survival: Hubungan Konversi Sputum Dengan Keberhasilan Pengobatan Pasien Tuberkulosis Resistan Obat Di Indonesia, Shena Masyita Deviernur, Nurhayati Adnan

Jurnal Epidemiologi Kesehatan Indonesia

Angka keberhasilan pengobatan Tuberkulosis Resistan Obat (TB RO) di Indonesia masih rendah. Konversi sputum dapat menjadi monitoring awal untuk memantau keberhasilan pengobatan. Penelitian ini bertujuan untuk melihat hubungan antara konversi sputum <3 bulan dengan keberhasilan pengobatan. Penelitian ini menggunakan desain studi kohort retrospektif dengan data yang bersumber dari sistem informasi tuberkulosis Kementerian Kesehatan RI. Populasi pada penelitian ini adalah pasien TB RO yang memulai pengobatan tahun 2020-2021 di Indonesia dengan jumlah sampel sebanyak 8.025 kasus dan participation rate sebesar 88,6%. Kurva Kaplan Meier dengan uji log-rank dibuat untuk analisis deskriptif, sedangkan analisis regresi Cox digunakan untuk melihat hubungan antara konversi sputum dengan keberhasilan pengobatan. Hasil analisis menunjukkan bahwa 45,9% pasien konversi sputum < 3 bulan pengobatan dengan 74,6% memiliki keberhasilan pengobatan. Secara keseluruhan median time untuk keberhasilan pengobatan berdasarkan konversi sputum < 3 bulan adalah bulan ke-18. Hasil analisis multivariat menunjukkan konversi sputum < 3 bulan 1,25 (95% CI 1,18-1,34) lebih tinggi peluangnya untuk mencapai keberhasilan pengobatan dibandingkan pasien yang tidak konversi < 3 bulan setelah dikontrol oleh status HIV dan paduan pengobatan. Berdasarkan hasil penelitian ini dapat disimpulkan bahwa monitoring konversi sputum dapat menjadi cara untuk melakukan monitoring keberhasilan pengobatan sedini mungkin. Konversi sputum merupakan standar yang dilakukan untuk pemantauan pengobatan pasien TB RO. Namun jumlah laboratorium yang dapat melakukan pemeriksaan untuk konversi pada pasien TB RO masih terbatas. Perlu adanya perluasan layanan dan peningkatan mutu layanan untuk melakukan pemeriksaan konversi sputum pada pasien TB RO.