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Murine Transporter Associated With Antigen Presentation (Tap) Preferences Influence Class I-Restricted T Cell Responses., A J Yellen-Shaw, C E Laughlin, R M Metrione, Laurence C. Eisenlohr

Department of Biochemistry and Molecular Biology Faculty Papers

The transporter associated with antigen presentation (TAP) complex shuttles cytosolic peptides into the exocytic compartment for association with nascent major histocompatibility complex class I molecules. Biochemical studies of murine and human TAP have established that substrate length and COOH-terminal residue identity are strong determinants of transport efficiency. However, the existence of these specificities in the intact cell and their influences on T cell responses have not been demonstrated. We have devised a method for studying TAP- mediated transport in intact cells, using T cell activation as a readout. The approach makes use of a panel of recombinant vaccinia viruses expressing …

Occupational Therapy's Link To Vocational Reeducation, 1910-1925., Sharon A. Gutman

Department of Occupational Therapy Faculty Papers

The development of occupational therapy is rooted in early 20th century medical reform. During the early 1910s, several members of the medical profession, human service workers, and the larger American society were increasingly disturbed by medical practices that did not consider the individual's personal experience of disability. Occupational therapy was developed, in part, out of this desire to provide persons with treatment that helped them to function in their communities despite their disability. Early occupational therapy leaders envisioned the fledgling profession as a societal service capable of assisting persons with disabilities to return to both work and community life. Vocational …

Predicting Red Blood Cell Transfusions In Very Low Birth Weight Infants Based On Clinical Risk Factors., David A. Paul, Stephen A. Pearlman, Kathleen H. Leef, John L. Stefano

Department of Pediatrics Faculty Papers

OBJECTIVE: To describe the clinical factors most predictive of red blood cell transfusion in very low birth weight (VLBW) infants.

STUDY DESIGN: Retrospective review of VLBW infants cared for at a single level III NICU during a two year period, n = 199.

RESULTS: Overall transfusion requirement was 4.6 +/- 6.2 transfusions/infant/hospital course. Length of hospital stay, days of mechanical ventilation, requirement for dopamine support, birth weight, initial hematocrit, periventricular leukomalacia and necrotizing enterocolitis all independently correlated with number of transfusions and donors. Bronchopulmonary dysplasia and patent ductus arteriosus were associated with donor but not transfusion number.

CONCLUSIONS: Our data …

Detection And Characterization Of Sp1 Binding Activity In Human Chondrocytes And Its Alterations During Chondrocyte Dedifferentiation., Rita M. Dharmavaram, Gang Liu, Sheryl D. Mowers, Sergio A. Jimenez

Department of Medicine Faculty Papers

We have detected DNA binding activity for a synthetic oligonucleotide containing an Sp1 consensus sequence in nuclear extracts from human chondrocytes. Changes in the levels of Sp1 oligonucleotide binding activity were examined in nuclear extracts from freshly isolated human chondrocytes, from chondrocytes that had been cultured under conditions that allowed the maintenance of a chondrocyte-specific phenotype on plastic dishes coated with the hydrogel poly(2-hydroxyethyl methacrylate), and from chondrocytes induced to dedifferentiate into fibroblast-like cells by passage in monolayer culture on plastic substrata. It was observed that Sp1 binding was 2-3-fold greater in nuclear extracts from dedifferentiated chondrocytes than in nuclear …

Nurses Alumni Association Bulletin, Fall 1997, Betty Piersol, Elizabeth K. Prisnock, Marian E. Smith, Margaret Summers, Sue Henrie-Strup, Maureen Mcvail

Nursing Alumni Bulletins

1997-1998 Meeting Dates Calendar

1998 Annual Luncheon-Meeting Notice

Officers and Committee Chairs

Bulletin Publication Committee

1997-1998 Meeting Dates Calendar

The President's Message

Treasurer's Report

Trivia and News About Our Graduates

Highlights of 1997

Keeping Kids Healthy After Hours

Scholarship Funds At Work

Tribute to Tanya

Medical Mission Outreach 1996

History Of The Jefferson Pin

Facts Not Fiction

Rib Ticklers

Mama Will Protect Me

Happy Birthday

Fiftieth Anniversary

Resume of Minutes of Alumni Association Meetings

Alumni Office News

Committee Reports

• Bulletin
• By-Laws
• Development
• Diploma School of Nursing Alumni Association-Mabel C. Prevost Scholarship Fund
• Nominating
• Relief Fund
• Satellite
• Social
• Scholarship

Luncheon Photos …

Anticoagulation And Elective Surgery., J. Spandorfer, G. Merli

Department of Medicine Faculty Papers

No abstract provided.

Stent Placement Compared With Balloon Angioplasty For Obstructed Coronary Bypass Grafts. Saphenous Vein De Novo Trial Investigators., M P Savage, J S Douglas, D L Fischman, C J Pepine, S B King, J A Werner, S R Bailey, P A Overlie, S H Fenton, J A Brinker, M B Leon, S Goldberg

Department of Medicine Faculty Papers

BACKGROUND: Treatment of stenosis in saphenous-vein grafts after coronary-artery bypass surgery is a difficult challenge. The purpose of this study was to compare the effects of stent placement with those of balloon angioplasty on clinical and angiographic outcomes in patients with obstructive disease of saphenous-vein grafts.

METHODS: A total of 220 patients with new lesions in aortocoronary-venous bypass grafts were randomly assigned to placement of Palmaz-Schatz stents or standard balloon angioplasty. Coronary angiography was performed during the index procedure and six months later.

RESULTS: As compared with the patients assigned to angioplasty, those assigned to stenting had a higher rate …

Aisr Connections, Winter 1997

The AC's Research Support Newsletter (Formerly AISR Connections)

No abstract provided.

Jefferson Alumni Bulletin – Volume Xlvi, Number 4, September 1997

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVI, Number 4, September 1997

University Awards Honorary Degree to Dr. Davis, Page 5

Luscombe, miller, and Staas Receive the Alumni Achievement Awards, Page 6

Clinic Presentations Address a Range of Fields, Page 8

Receptions Across Country Welcome College Leaders, Page 12

Landmark Diabetes Prevention Program, Page 21

Cardiology and Cardiothoracic Surgery Reception, Page 25

Annual Giving Tops $1.7 Million, Page 30

Mirizzi Syndrome Type Ii: Is Laparoscopic Cholecystectomy Justified?, D C Desai, R D Smink

Department of Surgery Faculty Papers

Mirizzi syndrome type II is an uncommon cause of obstructive jaundice caused by an inflammatory response to an impacted gallstone in Hartmann's pouch or the cystic duct with a resultant cholecystocholedochal fistula. Two cases of Mirizzi syndrome type II are presented. Clinically only one patient had jaundice and endoscopic retrograde cholangiopancreatogram (ERCP) established a preoperative diagnosis of Mirizzi syndrome. The other patient's diagnosis of Mirizzi syndrome was made intraoperatively. It is important to properly identify the anatomy at the time of surgery to avoid compromising the common bile duct. Operative treatment of Mirizzi syndrome type II includes laparoscopic or open …

Department Of Radiology-Annual Report-July 1, 1996 To June 30, 1997, David C. Levin

Department of Radiology Administrative Documents and Reports

Department of Radiology Annual Report, July 1, 1996 to June 30, 1997. Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States. 108 pages.

Chronicity In Strongyloides Stercoralis Infections: Dichotomy Of The Protective Immune Response To Infective And Autoinfective Larvae In A Mouse Model., R. A. Brigandi, H. L. Rotman, T. J. Nolan, G. A. Schad, D. Abraham

Department of Microbiology and Immunology Faculty Papers

Strongyloidiasis is an intestinal disease that can last for decades due to the occurrence of autoinfective larvae (L3a) in an infected person, which contribute to the maintenance of the population of adult worms in the intestine. The goal of the present study was to determine if L3a are susceptible to the protective immunity that targets the infective stage of the worm, the third-stage larvae (L3). Mice immunized and challenged with Strongyloides stercoralis L3 kill more than 90% of challenge larvae contained within diffusion chambers. The L3 do not remain antigenically static in mice, however, but undergo some degree of antigenic …

Jefferson Alumni Bulletin – Volume Xlvi, Number 3, June 1997

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVI, Number 3, June 1997

Dermatology and Cutaneous Biology, Page 4

Mutations in Cornea-Specific Proteins Are Cause of Fragile Eye Disease, Page 8

Albert Einstein Healthcare Network Becomes a Founding Member of the Jefferson Health System, Page 9

Innovative New Journal has Jefferson Roots, Page 11

Students Publish Pharmacology Study Guide, Page 12

JeffLINE Alumni Connection Offers Lifelong Learning, Page 23

1997 Commencement For Jefferson Medical College And College Of Graduate Studies

Jefferson College of Biomedical Sciences Commencement

No abstract provided.

1997 Commencement For Jefferson Medical College And College Of Graduate Studies

Sidney Kimmel Medical College Commencements

No abstract provided.

1997 Commencement For College Of Health Professions

Jefferson College of Nursing Commencements

No abstract provided.

1997 Commencement For College Of Health Professions

Jefferson College of Health Professions and Jefferson College of Pharmacy

No abstract provided.

Ureteroscopic Lithotripsy., Demetrius H. Bagley

Department of Urology Faculty Papers

There is a wide array of endoscopic lithotriptors presently available. Each of these has its own advantages and disadvantages. No single lithotriptor is suitable for all applications and none can meet the goal of fragmenting all calculi while remaining harmless to tissue.

Jefferson Alumni Bulletin – Volume Xlvi, Number 2, March 1997

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVI, Number 2, March 1997

Urology, Page 4

Report from the Alumni Trustees, Page 8

Student Notebook from 1831-33 Returns to Jefferson, Page 9

Named Professorships at Jeff, Page 10

Where the Alumni Are: A Map, Page 12

Why Does Melanoma Vaccine Work? An Answer, Page 14

Jefferson’s First Combined Kidney/Pancreas Transplant, Page 15

Dr. Shaedler is Honored for 29 Years of Teaching, Page 16

The Review - Winter 1997/1998

Jefferson Review

• A Standout OT Representative - 1
• PRO/CON on Managed Care and Physical Therapy - 5
• How to: Managing Dementia at Home - 6
• Biotechnology Opens With New Degree - 7
• Taking it to the Streets: CHP Community Service - 10
• Alumni Events - 12
• Alumni Notes - 14
• Donor List - 18

Parenting For Emotional Growth: Workshop Series For Parents And Other Caregivers, Henri Parens, Md

Parenting for Emotional Growth

The Workshops, like the Lesson Plans, contain many opportunities for the participants and students to learn both didactically and experientially by direct, live observations. Questions and discussions, role-plays, interactional exercises, written and oral lessons and occasional games provide ample opportunity to experience the Workshops contents both intellectually and emotionally.

Workshop Instructors must be cognizant of ethnicity-specific mores and customs of Workshop participants; guidelines are provided to facilitate such ethnic considerations.

1997 Clinic Yearbook, Amanda Grant Smith, Suzanne Yoder

Sidney Kimmel Medical College Yearbooks

The Clinic is the yearbook of the Sidney Kimmel Medical College (formerly Jefferson Medical College) at Thomas Jefferson University.

The History Of The Present Illness As Treatment: Who's Listening, And Why Does It Matter?, Herbert M. Adler, Md, Phd

Department of Family & Community Medicine Faculty Papers

BACKGROUND: The history of the present illness (HPI) is examined as a narrative communication that has the potential to be therapeutic.

METHODS: The general principles that influence the therapeutic potential of the HPI are induced from participant observation of personal experience and natural observations of conventional social interaction. These principles are corroborated by evidence from cross-cultural healing practices, clinical experience, and experimental psychology.

RESULTS: To facilitate a therapeutic HPI, the clinician should convey a sense of safety, sensitivity, affective competence, and cognitive competence. Furthermore, the effective clinician joins the patient in coprocessing the illness experience.

CONCLUSIONS: The (HPI) is not …

Jefferson Alumni Bulletin – Volume Xlvi, Number 1, December 1996

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVI, Number 1, December 1996

Rational Drug Design, Page 4

Technology Transfer, Page 7

Clinical Trials, Page 9

World-Class Athletes and Drugs, Page 12

The Makings of the Complete Physician, Page 14

Major Alliance Links Jefferson with Mercy Health, Page 17

“Gene Repair” Corrects Mutation Leading to Disease, Page 19

Genetic Discoveries Lead to New Lung Cancer Tests, Page 20

Alumni Can Participate in JeffHOPE, Page 24

Student AMA Organizes Bone Marrow Drive, Page 25

Glanzmann Thrombasthenia. Cooperation Between Sequence Variants In Cis During Splice Site Selection., Ying Jin, Harry C. Dietz, Robert A. Montgomery, William R. Bell, Iain Mcintosh, Barry Coller, Paul F. Bray

Cardeza Foundation for Hematologic Research

Glanzmann thrombasthenia (GT), an autosomal recessive bleeding disorder, results from abnormalities in the platelet fibrinogen receptor, GP(IIb)-IIIa (integrin alpha(IIb)beta3). A patient with GT was identified as homozygous for a G-->A mutation 6 bp upstream of the GP(IIIa) exon 9 splice donor site. Patient platelet GP(IIIa) transcripts lacked exon 9 despite normal DNA sequence in all of the cis-acting sequences known to regulate splice site selection. In vitro analysis of transcripts generated from mini-gene constructs demonstrated that exon skipping occurred only when the G-->A mutation was cis to a polymorphism 116 bp upstream, providing precedence that two sequence variations …

Nurses Alumni Association Bulletin, Fall 1996, Betty Piersol, Elizabeth K. Prisnock, Marian E. Smith, Margaret Summers, Deborah Fireman, Nicole Herndon

Nursing Alumni Bulletins

1996-1997 Meeting Dates Calendar

1997 Annual Luncheon-Meeting Notice Inside

Officers and Committee Chairs

Bulletin Publication Committee

1996-1997 Meeting Dates Calendar

The President's Message

Treasurer's Report

News About Our Graduates

Letter To Jefferson Nurses

Fiftieth Anniversary

Resume' of Minutes of Alumni Association Meetings

Alumni Office News

Nursing Up-Date 1995-1996

Scholarship Funds At Work

Diploma School of Nursing Alumni Association-Mabel C. Prevost Scholarship Report 1995

Women In Military Service For America Memorial Foundation

Operation Support Freedom - Humanitarian Aid to Kiev

The Best Mousetrap - Computers In Nursing

Christmas, As A Prisoner Of War

Restroom Policy

Happy Birthday

Committee Reports

• Bulletin
• Development …

Moving Occupation Into Treatment: Clinical Interpretation Of "Legitimizing Occupational Therapy's Knowledge"., Janice P. Burke

Department of Occupational Therapy Faculty Papers

No abstract provided.

Jefferson Alumni Bulletin – Volume Xlv, Number 4, September 1996

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLV, Number 4, September 1996

Commencement Addresses, Page 4

Clinic Presentations, Page 8

Annual Giving, Page 27

Bookstore, Page 54

Department Of Radiology-Annual Report-July 1, 1995 To June 30, 1996, David C. Levin

Department of Radiology Administrative Documents and Reports

Department of Radiology Annual Report, July 1, 1995 to June 30, 1996. Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States. 110 pages.

1996 Commencement For Jefferson Medical College And College Of Graduate Studies

Jefferson College of Biomedical Sciences Commencement

No abstract provided.