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1996 Commencement For Jefferson Medical College And College Of Graduate Studies

Sidney Kimmel Medical College Commencements

No abstract provided.

Jefferson Alumni Bulletin – Volume Xlv, Number 3, June 1996

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLV, Number 3, June 1996

Student Initiative and New Educational Challenges Converge in Community Primary Care, Page 4

Methodist Hospital and Thomas Jefferson University Hospital Merge Services, page 13

Kimmel Foundation Donates $10 Million, Establishing the Kimmel Cancer Center, Page 13

Capizzi Succeeds Caro as Chairman of Medicine, Page 17

DiMarino Appointed Chief of Gastroenterology, Page 17

Book Portrays C. Earl Albrecht ’32 in Alaska, Page 22

Leonard Zon ’83 Continues in Erslev’s Footsteps, Page 25

Is The Use Of Life History And Narrative In Clinical Practice Reimbursable? Is It Occupational Therapy?, Janice P. Burke, Stephen B. Kern

Department of Occupational Therapy Faculty Papers

No abstract provided.

A Polymorphism Of A Platelet Glycoprotein Receptor As An Inherited Risk Factor For Coronary Thrombosis., Ethan J. Weiss, Paul F. Bray, Matthew Tayback, Steven P. Schulman, Thomas S. Kickler, Lewis C. Becker, James L. Weiss, Gary Gerstenblith, Pascal J. Goldschmidt-Clermont

Cardeza Foundation for Hematologic Research

BACKGROUND: Platelet glycoprotein IIb/IIIa is a membrane receptor for fibrinogen and von Willebrand factor, and it has an important role in platelet aggregation. It is known to be involved in the pathogenesis of acute coronary syndromes. Previously, we found a high frequency of a particular polymorphism, PlA2, of the gene encoding glycoprotein IIIa in kindreds with a high prevalence of premature myocardial infarction.

METHODS: To investigate the relation between the PlA2 polymorphism and acute coronary syndromes, we conducted a case-control study of 71 case patients with myocardial infarction or unstable angina and 68 inpatient controls without known heart disease. The …

A Tandem Duplication Within The Fibrillin 1 Gene Is Associated With The Mouse Tight Skin Mutation., Linda D. Siracusa, Rodney Mcgrath, Qing Ma, John J. Moskow, Jayanthi Manne, Paul J. Christner, Arthur M. Buchberg, Sergio A. Jimenez

Department of Medicine Faculty Papers

Mice carrying the Tight skin (Tsk) mutation have thickened skin and visceral fibrosis resulting from an accumulation of extracellular matrix molecules. These and other connective tissue abnormalities have made Tskl + mice models for scleroderma, hereditary emphysema, and myocardial hypertrophy. Previously we localized Tsk to mouse chromosome 2 in a region syntenic with human chromosome 15. The microfibrillar glycoprotein gene, fibrillin 1 (FBN1), on human chromosome 15q, provided a candidate for the Tsk mutation. We now demonstrate that the Tsk chromosome harbors a 30- to 40-kb genomic duplication within the Fbn1 gene that results in a larger than normal in-frame …

Jefferson Alumni Bulletin – Volume Xlv, Number 2, March 1996

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLV, Number 2, March 1996 A Conversation with the Alumni Chairman of Family Medicine, Page 4 Stanton N. Smullens ’61: Jefferson Leader, Page 14 Hospital Separates from University as Step in Forming the Jefferson Health System, Page 15 Gene That Helps Cause Gliomas is Identified, Page 16 Altered FHIT Gene is Found in Several Types of Common Cancers, Page 17 Vaccine Treats Rheumatoid Arthritis, Page 18 Blood Test Can Measure Obesity Hormone, Page 19 Gene Therapy for HIV-Infected Patients Will Begin Here, Page 21 Spitzer Authors Neonatology Text, Page 23 Gallo Discovers HIV-Suppresor Factors, page …

Strategies For Prevention Of Varicella Pneumonia: A Cost-Effectiveness Analysis., G A Macones, S Ewing, N S Silverman

Department of Obstetrics and Gynecology Faculty Papers

OBJECTIVE: The objective of this study was to compare the cost-effectiveness of 3 strategies of serologic enzyme-linked immunosorbent assay (ELISA) testing and post-exposure varicella zoster immune globulin (VZIG) prophylaxis for the prevention of maternal varicella pneumonia during pregnancy in patients with negative or uncertain histories of varicella infection.

METHODS: A decision tree was constructed to compare the following strategies: 1) routine serologic testing for varicella immunity followed by targeted post-exposure VZIG prophylaxis, 2) post-exposure serologic testing followed by targeted VZIG prophylaxis, and 3) untargeted post-exposure VZIG administration. The probabilities for the model were obtained from the medical literature and supplemented …

Jefferson Alumni Bulletin – Volume Xlv, Number 1, December 1995

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLV, Number 1, December 1995

We will fight cancer with molecular therapeutics and prediagnostics, page 4

Behavior and economics will challenge prevention, page 6

From genetic understanding to cure, page 9

Computer-based teaching reshapes how students learn, page 12

Will tomorrow’s journals be electronic? Page 14

Jefferson health system upgrades its information technology, page 17

Molecule essential for cell growth and division is discovered at Jeff, page 19

Stimulation Of Alpha 1(I) Procollagen Gene Expression In Nih-3t3 Cells By The Human T Cell Leukemia Virus Type 1 (Htlv-1) Tax Gene., E. Munoz, D. Suri, S. Amini, K. Khalili, Sergio A. Jimenez

Selected Works of Sergio Jiménez, MD, MACR

The mechanisms that regulate the expression of genes encoding extracellular matrix proteins in fibroblasts and other mesenchymal cells have remained elusive. Studies from several laboratories have indicated that Tax, a trans-regulatory protein from the human T cell leukemia virus type I not only augments viral gene expression but also triggers the expression of various cellular genes. Here, we examined the hypothesis that the expression of collagen genes may also be modulated by Tax. NIH-3T3 cells were simultaneously transfected with a Tax expressor plasmid and a chimeric construct containing regulatory sequences (-804 to +42 bp) of the alpha 1(I) procollagen gene …

Nurses Alumni Association Bulletin, Fall 1995, Alice C. Boehret, Eleanor Kowaleski Larson, Nancy Powell, Dorothy R. Long, Pamela G. Watson, Betty Piersol, Margaret Summers, Sara Entriken, Jane Ryan Dietrich, Paula J. Levine, Lorraine Mccall, Doris E. Bowman, Linda Meachum Scheetz, Mary Kulys, Ethel Gillette

Nursing Alumni Bulletins

1995-1996 Meeting Dates Calendar

1996 Annual Luncheon-Meeting Notice

Officers and Committee Chairs

Bulletin Publication Committee

1995-1996 Meeting Dates Calendar

The President's Message

Financial Report

What's New

Fiftieth Anniversary

Resume of Minutes of Alumni Association Meetings

Scholarship Funds at Work

CAHS Alumni Board/Diploma School

Alumni Office News

Jefferson Health System

Oldest Veteran Dies

1OOth Anniversary

Pearl Harbor Remembered

"Memories"

Janet Hindson Retires

Happy Birthday

Scholarship Fund donors for 1994

Committee Reports

By-Laws

Development

Bulletin

Relief Fund

Satellite

Social

Scholarship

In Memoriam, Names of Deceased Graduates

Class News

Luncheon Photos

Jefferson Alumni Identification Card

The Diploma School of Nursing Alumni Association-Mabel C. …

Computer-Assisted Instruction As A Learning Resource For Applied Anatomy And Kinesiology In The Occupational Therapy Curriculum., Susan Toth-Cohen

Department of Occupational Therapy Faculty Papers

OBJECTIVES: The purpose of these studies was to examine the learning outcomes of a computer-assisted instruction (CAI) tutorial in applied anatomy and kinesiology for occupational therapy students and to determine its applicability for use in two university settings.

METHOD: Two separate pilot studies were conducted at two universities. In each study, the learning outcomes of an experimental group of occupational therapy students using a CAI program and a control group using books to study the same material were compared. Learning outcomes were assessed with post-test achievement test scores on an applied anatomy and kinesiology test and responses to an attitude …

Aisr Connections, Fall 1995

The AC's Research Support Newsletter (Formerly AISR Connections)

No abstract provided.

Impact Of Spinal Cord Injury On The Life Roles Of Women., M Claire Quigley

Department of Occupational Therapy Faculty Papers

This qualitative study was conducted to explore and describe the role experience of five women whose lives were disrupted by a traumatic spinal cord injury and who later returned to their communities after completing intensive rehabilitation programs. In-depth interviews and participant observations were used to examine the experiences of these women. The findings exemplify how the women's use of adaptation and negotiation and the development of a new role as self-advocate facilitated the reestablishment of their life roles. As the women's occupational roles were redefined, the processes of adaptation and negotiation were evident in three aspects of their lives: daily …

Jefferson Alumni Bulletin – Volume Xliv, Number 4, September 1995

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLIV, Number 4, September 1995 Anniversary galas, page 4 and 24 Jefferson health system in established by the university and main line health, page 12 Research, page 14 Appointments, page 20 Books, page 22 Journal of neurovirology is founded, page 22

Anti-Human Immunodeficiency Virus (Hiv) Activities Of Halogenated Gomisin J Derivatives, New Nonnucleoside Inhibitors Of Hiv Type 1 Reverse Transcriptase, Toshiaki Fujihashi, Hiroto Hara, Toshiya Sakata, Kazuya Mori, Hirotaka Higuchi, Akio Tanaka, Hideko Kaji, Akira Kaji

Department of Biochemistry and Molecular Biology Faculty Papers

Halogenated gomisin J (a derivative of lignan compound), represented by the bromine derivative 1506 [(6R, 7S, S-biar)-4,9-dibromo-3,10-dihydroxy-1,2,11,12-tetramethoxy-6, 7-dimethyl-5,6,7,8- tetrahydrodibenzo[a,c]cyclo-octene], was found to be a potent inhibitor of the cytopathic effects of human immunodeficiency virus type 1 (HIV-1) on MT-4 human T cells (50% effective dose, 0.1 to 0.5 microM). Gomisin J derivatives were active in preventing p24 production from acutely HIV-1-infected H9 cells. The selective indices (toxic dose/effective dose) of these compounds were as high as > 300 in some systems. 1506 was active against 3'-azido-3'-deoxythymidine-resistant HIV-1 and acted synergistically with AZT and 2',3'-ddC. 1506 inhibited HIV-1 reverse transcriptase (RT) in …

Computer-Based Learning For Esrd Patient Education: Current Status And Future Directions, Jeanette K. Chambers, Anthony J. Frisby

Academic Commons and Scott Memorial Library Staff Papers and Presentations

Computer use in everyday life has expanded human potential in virtually every possible arena. In health care, computer technology affects direct clinical care through diagnostics, treatment, monitoring, and documentation processes. Patient care systems use computer technology to manage billing, scheduling, and multiple other administrative functions. Computer technology for education of health care professionals has been primarily in elected undergraduate, graduate, and professional degree programs. Computer-based continuing education for health care professionals has been available for at least a decade, but computer-based patient education is just now beginning to emerge as a learning options. This article describes examples of patient education …

Department Of Radiology-Annual Report-July 1, 1994 To June 30, 1995, David C. Levin

Department of Radiology Administrative Documents and Reports

Department of Radiology Annual Report, July 1, 1994 to June 30, 1995. Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States. 120 pages.

1995 Commencement For Jefferson Medical College And College Of Graduate Studies

Jefferson College of Biomedical Sciences Commencement

No abstract provided.

1995 Commencement For Jefferson Medical College And College Of Graduate Studies

Sidney Kimmel Medical College Commencements

No abstract provided.

Increased Abundance Of The Receptor-Type Protein-Tyrosine Phosphatase Lar Accounts For The Elevated Insulin Receptor Dephosphorylating Activity In Adipose Tissue Of Obese Human Subjects, Falyaz Ahmad, Robert V. Considine, Barry J. Goldstein

Department of Medicine Faculty Papers

Protein-tyrosine phosphatases (PTPases) have an essential role in the regulation of the steady-state phosphorylation of the insulin receptor and other proteins in the insulin signalling pathway. To examine whether increased PTPase activity is associated with adipose tissue insulin resistance in human obesity we measured PTPase enzyme activity towards the insulin receptor in homogenates of subcutaneous adipose tissue from a series of six lean and six nondiabetic, obese (body mass index > 30) subjects. The obese subjects had a mean 1.74-fold increase in PTPase activity (P < 0.0001) with a striking positive correlation by linear regression analysis between PTPase activity and body mass index among all of the samples (R = 0.918; P < 0.0001). The abundance of three candidate insulin receptor PTPases in adipose tissue was also estimated by immunoblot analysis. The most prominent increase was a 2.03-fold rise in the transmembrane PTPase LAR (P < 0.001). Of the three PTPase examined, only immunodepletion of LAR protein from the homogenates with neutralizing antibodies resulted in normalization of the PTPase activity towards the insulin receptor, demonstrating that the increase in LAR was responsible for the enhanced PTPase activity in the adipose tissue from obese subjects. These studies suggest that increased PTPase activity towards the insulin receptor is a pathogenetic factor in the insulin resistance of adipose tissue in human obesity and provide evidence for a potential role of the LAR PTPase in the regulation of insulin signalling in disease states.

1995 Commencement For College Of Allied Health Sciences

Jefferson College of Health Professions and Jefferson College of Pharmacy

No abstract provided.

1995 Commencement For College Of Allied Health Sciences

Jefferson College of Nursing Commencements

No abstract provided.

Increased Alpha 1(I) Procollagen Gene Expression In Tight Skin (Tsk) Mice Myocardial Fibroblasts Is Due To A Reduced Interaction Of A Negative Regulatory Sequence With Ap-1 Transcription Factor., Neena Philips, Reza I. Bashey, Sergio A. Jimenez

Department of Medicine Faculty Papers

The TSK mouse, a model of fibrosis, displays exaggerated connective tissue accumulation in skin and visceral organs including the heart. To study the mechanisms of myocardial fibrosis in TSK mice, we established several strains of TSK mice myocardial fibroblasts in culture and examined the regulation of collagen gene expression in these cells. These strains displayed increased collagen gene expression in comparison with myocardial fibroblasts established from normal mice. On an average, the TSK myocardial fibroblast cultures showed a 4-fold increase in collagen synthesis and 4.4- and 3.6-fold increases, respectively, in alpha 1(I) and alpha 1(III) collagen mRNA steady state levels. …

Jefferson Alumni Bulletin – Volume Xliv, Number 3, Spring 1995

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLIV, Number 3, Spring 1995

A brief history, page 4

Then and now, page 9

Views of the campus, page 14

Jefferson facts, page 14

A host of remarkable graduates, page 17

Jefferson looks to the future, page 20

Aisr Connections, Spring 1995

The AC's Research Support Newsletter (Formerly AISR Connections)

No abstract provided.

1995 The Analysis, Michele Ruda

Philadelphia University Yearbooks

No abstract provided.

Parenting For Emotional Growth: Lines Of Development, Henri Parens, Md

Parenting for Emotional Growth

In developing the Parenting for Emotional Growth Textbook, we planned to structure the units in such a way that the same issues, be it the development of self and relationships, of aggression, etc., would be addressed in the same sequence at the various stage levels of the child's development. Thus, in the Textbook, the issues will be ordered in the same sequence in all of the units.

While using the textbook for classroom or workshop preparation or for individual study, some users have sought to follow one or another particular line of development through the length of its …

Parenting For Emotional Growth: Textbook, Henri Parens, Md

Parenting for Emotional Growth

This textbook, on which the Parenting for Emotional Growth Curriculum, Workshops, and Lines of Development are based, is highly detailed and is based in psychodynamic theories that address parenting issues pertinent to optimizing the child's psychological development, mental well-being, and abilities to adapt constructively. The presentation of materials is organized by the rationale that when parents know, understand, and can positively handle the child's evolving emotional and experiential needs and psychological developments, the parents' rearing strategies tend to better optimize their children's developmental potential than when such knowledge, understanding, and handling are lacking. It is exactly because this …

1995 Clinic Yearbook, Natalie Yeaney

Sidney Kimmel Medical College Yearbooks

The Clinic is the yearbook of the Sidney Kimmel Medical College (formerly Jefferson Medical College) at Thomas Jefferson University.

Mentorship Experiences In A Group Of Occupational Therapy Leaders., Ruth Levine Schemm, Theodore Bross

Department of Occupational Therapy Faculty Papers

OBJECTIVES: The development of occupational therapy leaders is a long-held goal of many members of the American Occupational Therapy Association and of state associations. The initiation of mentor programs is a common means to accomplish this goal. These programs take time and effort, and, although occupational therapists have described how mentorship programs work in the literature, there are few articles that describe the actual mentorship experiences of occupational therapy leaders.

METHOD: To study the experiences of elected occupational therapy leaders, a 30-item questionnaire was distributed at the annual meeting of the Committee of State Association Presidents and completed by 53 …