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1999 Commencement For College Of Health Professions

Jefferson College of Health Professions and Jefferson College of Pharmacy

No abstract provided.

Signal Transducer And Activator Of Transcription (Stat)5 Activation By Bcr/Abl Is Dependent On Intact Src Homology (Sh)3 And Sh2 Domains Of Bcr/Abl And Is Required For Leukemogenesis., M Nieborowska-Skorska, M A Wasik, A Slupianek, P Salomoni, T Kitamura, B Calabretta, T Skorski

Department of Microbiology and Immunology Faculty Papers

Signal transducer and activator of transcription (STAT)5 is constitutively activated in BCR/ ABL-expressing cells, but the mechanisms and functional consequences of such activation are unknown. We show here that BCR/ABL induces phosphorylation and activation of STAT5 by a mechanism that requires the BCR/ABL Src homology (SH)2 domain and the proline-rich binding site of the SH3 domain. Upon expression in 32Dcl3 growth factor-dependent myeloid precursor cells, STAT5 activation-deficient BCR/ABL SH3+SH2 domain mutants functioned as tyrosine kinase and activated Ras, but failed to protect from apoptosis induced by withdrawal of interleukin 3 and/or serum and did not induce leukemia in severe combined …

Radiculopathy And Myelopathy At Segments Adjacent To The Site Of A Previous Anterior Cervical Arthrodesis., Alan S. Hilibrand, Gregory D. Carlson, M A Palumbo, P K Jones, H H Bohlman

Rothman Institute Papers

BACKGROUND: We studied the incidence, prevalence, and radiographic progression of symptomatic adjacent-segment disease, which we defined as the development of new radiculopathy or myelopathy referable to a motion segment adjacent to the site of a previous anterior arthrodesis of the cervical spine.

METHODS: A consecutive series of 374 patients who had a total of 409 anterior cervical arthrodeses for the treatment of cervical spondylosis with radiculopathy or myelopathy, or both, were followed for a maximum of twenty-one years after the operation. The annual incidence of symptomatic adjacent-segment disease was defined as the percentage of patients who had been disease-free at …

Jefferson Alumni Bulletin – Volume Xlviii, Number 1, March 1999

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVIII, Number 1, March 1999 Otolaryngology-Head and Neck Surgery, Page 4 Gene Therapy in a Liquid: an Easier Treatment, Page 10 Gene Repair Technique is Developed, Page 10 Moving Closer to Gene Therapy for Lung Cancer, Page 11 Frankford Hospital Joins Jefferson Health System, Page 14 Dean Gonnella Receives AAMC’s Flexner Award, Page 17

Integrin-Dependent Control Of Translation: Engagement Of Integrin Alphaiibbeta3 Regulates Synthesis Of Proteins In Activated Human Platelets., Ravinder Pabla, Andrew S. Weyrich, Dan A. Dixon, Paul F. Bray, Thomas M. Mcintyre, Stephen M. Prescott, Guy A. Zimmerman

Cardeza Foundation for Hematologic Research

Integrins are widely expressed plasma membrane adhesion molecules that tether cells to matrix proteins and to one another in cell-cell interactions. Integrins also transmit outside-in signals that regulate functional responses of cells, and are known to influence gene expression by regulating transcription. In previous studies we found that platelets, which are naturally occurring anucleate cytoplasts, translate preformed mRNA transcripts when they are activated by outside-in signals. Using strategies that interrupt engagement of integrin alphaIIbbeta3 by fibrinogen and platelets deficient in this integrin, we found that alphaIIbbeta3 regulates the synthesis of B cell lymphoma 3 (Bcl-3) when platelet aggregation is induced …

Department Of Radiology-Annual Executive Summary Report-July 1, 1998 To June 30, 1999, David C. Levin, M.D.

Department of Radiology Administrative Documents and Reports

102 page Department of Radiology Annual Executive Summary Report, July 1, 1998 to June 30, 1999, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States.

Classifying Quality Nursing Care Initiatives: Framework For Ambulatory Surgery Nursing Practice, Beth Ann Swan

College of Nursing Faculty Papers & Presentations

The demand for information about quality is greater now than ever. Despite the significance of quality to consumers, providers, and insurers of health care, information related to this phenomenon, although plentiful, has been plagued by the lack of consistent definitions, frameworks, and outcome measurements. This inconsistency leads to the inability to compare and evaluate patient outcomes from study to study and across practice settings. Assessing recovery, including symptom distress and functioning, is increasingly significant because extended operations requiring longer anesthesia are being performed in the ambulatory surgery setting. Outcomes must be linked to specific processes, and outcome information should include …

Nurses Alumni Association Bulletin, Fall 1998, Betty Piersol, Elizabeth K. Prisnock, Marian E. Smith, Margaret Summers

Nursing Alumni Bulletins

1998-1999 Meeting Date Calendar

1999 Annual Luncheon & Meeting Notice

Fall Social

Officers and Committee Chairs

Bulletin Publication Committee

The President's Message

Treasurer's Report

News About Our Graduates

Highlight Of 1998

Operation Smile

Scholarship Funds At Work

Romania Trip

Double Honors

Doris Bowman

Memorial Service For Janet Hindson "A time for everything"

On the Lighter Side

Twenty Ways to Kill an Organization

Happy Birthday

Fiftieth Anniversary

Resume Alumni Association Meetings

Alumni Office News

Committee Reports

• Bulletin
• By-Laws
• Relief Fund
• Social
• Scholarship
• Development
• Nominating

Luncheon Photos

In Memoriam, Names of Deceased Graduates

Class News

Certification Reimbursement Application

Relief Fund Application

Scholarship …

Jefferson Alumni Bulletin – Volume Xlvii, Number 4, October 1998

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVII, Number 4, October 1998

Flanagan, Gallo, and Nadel are Honored with the Alumni Achievement Awards, Page 6

Clinic Presentations Treat a Range of Fields, Page 8

Alumni are Invited to Compete for the Gratz Prize, Page 13

Annual Giving Tops Two Million Dollars, Page 26

Aisr Connections, Fall 1998 (1998-1999 Orientation Issue)

The AC's Research Support Newsletter (Formerly AISR Connections)

No abstract provided.

Jefferson Alumni Bulletin – Volume Xlvii, Number 3, July 1998

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVII, Number 3, July 1998

Drug Development and Clinical Trials, Page 4

Thomas Jefferson university Hospital is Ranked One of the Top 100 in the Country, Page 8

The W.W. Smith Charitable Trust Gives $1.5 Million, Page 9

First GI Text from an Endoscopic Perspective, Page 9

Brucker Lecture on Refocusing of Managed Care, Page 10

Gene Therapy for Canavan’s Disease, Page 11

Decorin May Be a Natural Cancer Fighter in Cells, Page 13

Clue to How a Protein Works to Suppress Tumors, Page 13

Francis Elected to ACP Board of Regents, Page 23

Department Of Radiology-Annual Report-July 1, 1997 To June 30, 1998, David C. Levin

Department of Radiology Administrative Documents and Reports

Department of Radiology Annual Executive Summary Report, July 1, 1997 to June 30, 1998. Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States. 103 pages.

Expression Of Constitutively Active Raf-1 In The Mitochondria Restores Antiapoptotic And Leukemogenic Potential Of A Transformation-Deficient Bcr/Abl Mutant., P Salomoni, M A Wasik, R F Riedel, K Reiss, J K Choi, T Skorski, B Calabretta

Department of Microbiology and Immunology Faculty Papers

The oncogenic BCR/ABL protein protects hematopoietic cells from apoptosis induced by growth factor deprivation, but the mechanisms are only partially understood. A BCR/ABL mutant lacking amino acids 176-426 in the BCR domain (p185DeltaBCR) failed to protect interleukin 3-deprived 32Dcl3 myeloid precursor cells from apoptosis, although it possessed tyrosine kinase activity and was capable of activating the Ras-Raf-MAP kinase pathway. Compared to p185 wild-type transfectants, p185DeltaBCR-transfected cells showed markedly reduced levels of Bcl-2 and expressed the hypophosphorylated, proapoptotic form of BAD. Bcl-2 expression in the mitochondrial fraction of p185DeltaBCR cells was also markedly diminished and mitochondrial RAF was undetectable. In p185DeltaBCR …

Clinical Problem-Solving. Through Thick And Thin., David R. Yu, Redonda Miller, Paul F. Bray

Cardeza Foundation for Hematologic Research

No abstract provided.

Clinical Interpretation Of "Health And The Human Spirit For Occupation"., Janice P. Burke

Department of Occupational Therapy Faculty Papers

In reading and contemplating Yenca's (1998) article, I was immediately struck by the utility of the ideas she offers on a number of clinical fronts. We are presented with occupation-based strategies that are directly applicable to our work with patients and program development; we can make use of the language and ideas that are offered as a way to begin talking to one another (therapist to therapist) in clinical settings about occupation; and we are given the opportunity to think about the contribution, value, and efficacy of occupation and how we might convert those ideas into clinically based research actions. …

Postoperative Nursing Care Contributions To Symptom Distress And Functional Status After Ambulatory Surgery, Beth Ann Swan

College of Nursing Faculty Papers & Presentations

The relationship of postoperative patient-perceived nurse caring behaviors to symptom distress and functional status in 100 adult ambulatory surgical patients was examined. These behaviors explained 9.3% to 18.2% of the variance in functional status on the 1st, 4th, and 7th day postsurgery, and 10% of the variance in symptom distress on the 7th postoperative day after controlling for ASA physical status classification, preoperative symptom distress, and preoperative functional status.

1998 Commencement For College Of Health Professions

Jefferson College of Nursing Commencements

No abstract provided.

1998 Commencement For College Of Health Professions

Jefferson College of Health Professions and Jefferson College of Pharmacy

No abstract provided.

The Baculovirus Anti-Apoptotic P35 Protein Promotes Transformation Of Mouse Embryo Fibroblasts., M Resnicoff, B. Valentinis, D. Herbert, D. Abraham, P D. Friesen, E. S. Alnemri, R Baserga

Department of Microbiology and Immunology Faculty Papers

The baculovirus p35 protein is a potent inhibitor of programmed cell death induced by a variety of stimuli in insects, nematodes, and mammalian cell lines. The broad ability of p35 in preventing apoptosis has led us to investigate its effect on mouse embryo fibroblasts in vitro and in vivo. For this purpose, we have used R- cells (3T3-like fibroblasts derived from mouse embryos with a targeted disruption of the insulin-like growth factor I receptor (IGF-IR) genes) and R508 cells (derived from R- and with 15 x 10(3) IGF-IRs per cell). Both cell lines grow normally in monolayer, but they do …

Identification Of Fetal Dna And Cells In Skin Lesions From Women With Systemic Sclerosis, Carol M. Artlett, J. Bruce Smith, Sergio A. Jimenez

Selected Works of Sergio Jiménez, MD, MACR

BACKGROUND: Systemic sclerosis is a disease of unknown origin which often occurs in women after their childbearing years. It has many clinical and histopathological similarities to chronic graft-versus-host disease. Recent studies indicate that fetal stem cells can survive in the maternal circulation for many years post partum. This finding suggests that fetal cells persisting in the maternal circulation or tissues could be involved in the pathogenesis of systemic sclerosis by initiating a graft-versus-host reaction.

METHODS: We used the polymerase chain reaction (PCR) to identify Y-chromosome sequences in DNA extracted from peripheral-blood cells and skin lesions from women with systemic sclerosis …

How Occupational Therapists Teach Older Patients To Use Bathing And Dressing Devices In Rehabilitation., Ruth Levine Schemm, Laura N. Gitlin

Department of Occupational Therapy Faculty Papers

OBJECTIVE: This article describes the methods occupational therapists use to teach bathing and dressing device use to older patients in rehabilitation programs. The relationship of three patient characteristics to five aspects of assistive device instruction was examined.

METHOD: The study sample included 86 patients and 19 occupational therapists who provided the assistive device training. Patients were 55 years of age or older and in rehabilitation for an orthopedic deficit, cerebrovascular accident, or lower limb amputation. Therapists recorded information on teaching methods, perceptions of patient knowledge, and expectations for future device use after each treatment session.

RESULTS: Patients received an average …

Jefferson Alumni Bulletin – Volume Xlvii, Number 2, March 1998

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVII, Number 2, March 1998

Department Restructurings Respond to the Evolution in Scientific Disciplines, Page 4

The Rb2/p130 Gene and Endometrial Cancer, Page 7

Gene Therapy Trial for Glioblastoma, Page 8

Ovarian Cancer Vaccine is Promising in First Tests, Page 9

Transgenic Mouse for Study of Photoaging, Page 10

Uric Acid Reduces MS Symptoms in Mice, Page 11

Albert Einstein Healthcare Network Will Join Jefferson Health System by July, Page 12

Proposed Amendments to Alumni Association Bylaws, Page 14

Joseph Seltzer, ’71, the Next Alumni President, Page 15

Wallace Miller ’56 Receives RSNA Gold Medal, …

Mitochondrial Myopathy With Atypical Subacute Presentation, Oren Cohen, Israel Steiner, Zohar Argov, Avi Ashkenazi, Judith Diment, Ann Saada, Yaron River

Department of Neurology Faculty Papers

Mitochondrial myopathies usually have a chronic course of progressive limb weakness, exercise induced myalgia without muscle tenderness, and normal or only mildly raised serum creatine kinase. Acute or subacute presentation or exacerbation of nervous system signs is common in Leber's hereditary optic neuropathy (LHON) and in mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), but has not been reported for muscle in mitochondrial diseases. We describe a patient who presented with rapidly progressive, subacute muscle weakness due to a mitochondrial disorder.

Student Level Ii Fieldwork Failure: Strategies For Intervention., Sharon A. Gutman, Paula Mccreedy, Prudence Heisler

Department of Occupational Therapy Faculty Papers

OBJECTIVE: This report describes how common student communicative and behavioral characteristics that appear to predict the existence of potential problems during Level II fieldwork were identified in order to develop and implement preventative interventions during the academic curriculum at New York University (NYU). RECORD REVIEW: A record review of NYU professional-level occupational therapy students from 1986 to 1995 was completed to identify common factors among students who performed well academically but failed clinical fieldwork. Eight communicative and behavioral characteristics were identified: (a) rigidity of thinking, (b) discomfort with the ambiguity that accompanies clinical reasoning, (c) lack of psychological insight, (d) …

The Review - Fall/Winter 1998

Jefferson Review

IN THIS ISSUE

• Conference Explores Alternative Therapies for Healing and Health - 2
• Nursing Master's Graduates Choose from a Variety of Advance-Practice Opportunities - 3
• MSN Student Finds Satisfaction in Empowering Clients - 3
• Alumni-Owned Businesses - 4
• Project IMPART Increasing Minority Participation in Nursing Research Careers - 7
• Student Life Award Recipient Builds Awareness, Understanding of OT - 8
• Alumni Notes - 9
• Alumni Update - 10
• College Notes - 12
• Talk-Up Your Alma Mater - 13

1998 The Analysis, Kimberley O'Dowd

Philadelphia University Yearbooks

No abstract provided.

Initial Multicenter Experience With Double Nucleoside Therapy For Human Immunodeficiency Virus Infection During Pregnancy., N S Silverman, D H Watts, J Hitti, D M Money, E Livingston, J Axelrod, J M Ernest, D Robbins, M M Divito

Department of Obstetrics and Gynecology Faculty Papers

OBJECTIVE: To study maternal and neonatal effects of combination nucleoside analog therapy administered to human immunodeficiency virus (HIV)-infected pregnant women for maternal indications.

METHODS: A multicenter, prospective observational study was undertaken at six perinatal centers in the United States and Canada that supported regional referral programs for the treatment of HIV-infected pregnant women. Demographic, laboratory, and pregnancy outcome data were collected for 39 women whose antiretroviral treatment regimens were expanded to include more than one nucleoside analog for maternal indications. The 40 newborns were monitored at pediatric referral centers through at least three months of age to ascertain their HIV …

Determinants Of Antepartum Human Immunodeficiency Virus Testing In A Non-Medicaid Obstetric Population., E Cardonick, S Daly, M Dooley, K Elles, N S Silverman

Department of Obstetrics and Gynecology Faculty Papers

OBJECTIVE: To determine voluntary human immunodeficiency virus (HIV) testing rates and factors influencing testing in a private obstetric practice.

METHODS: Antepartum patients were offered HIV testing after completing a self-assessment questionnaire. Perceived risks and demographics were correlated with testing rates.

RESULTS: Overall, 348/600 (58%) women consented to HIV testing. In a univariate analysis, patients with "any" perceived risk(s) were more likely to be tested. Single women and those with an at-risk partner(s) or a history of sexually transmitted disease (STD) were more likely to desire testing. These factors remained independently associated with voluntary testing in a multivariate regression model. No …

Jefferson Alumni Bulletin – Volume Xlvii, Number 1, December 1997

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVII, Number 1, December 1997 Annual Giving Celebrates a Half-Century of Strengthening Jefferson, Page 4 Screening for Breast Cancer: A Continuing Dilemma, Page 8 The McClellan house: A Link to the University’s Past, Page 12 The Bulletin Reaches its 75th Year, Page 17 Landmark Breast Cancer Meeting at Jefferson, Page 21 University and SmithKline Beecham Link Clinical Research, Page 22 Missing Cancer-Suppressor Genes May Have Deadly Effects, Page 23 Goldstein is Vice President for Research at JDFI, Page 27 Brezinski Develops Noninvasive Method to Detect Early Signs of Cancer and Heart Attacks, Page 29

Anthroposophic Perspectives In Primary Care, Ira S. Cantor Md, Steven Rosenzweig Md

Department of Emergency Medicine Faculty Papers

A core challenge of contemporary medicine is to integrate the technological successes of biomedical science with a comprehensive under-standing of the physical, psychosocial, ecological, and spiritual dimensions of health and illness. Toward this end, bridges are being created between conventional medicine and alternative systems of healing which reflect a holistic model of the human being. Even when both conventional and complementary approaches are used side-by-side in the same patient, they remain separate in their basic assumptions and goals. Today's mechanistic disease model is cut off from such notions as life-energy, consciousness, and spirituality, so integral to many alternative paradigms. Anthroposophically …