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Full-Text Articles in Entire DC Network
Expression And Purification Of Porcine Pid1 Gene In Escherichia Coli, Huan Wang, Xiaoling Chen, Zhiqing Huang, Bo Zhou, Gang Jia, Guangmang Liu, Hua Zhao
Expression And Purification Of Porcine Pid1 Gene In Escherichia Coli, Huan Wang, Xiaoling Chen, Zhiqing Huang, Bo Zhou, Gang Jia, Guangmang Liu, Hua Zhao
Turkish Journal of Biology
In this study, in order to scale up the production of recombinant porcine phosphotyrosine interaction domain containing 1 (pPID1), a pET-28a (+)-pPID1 expression plasmid was constructed and transformed into Escherichia coli Rosetta (DE3). The recombinant pPID1 was then purified and identified by western blotting, and was also analyzed in vitro for its function. The recombinant protein was tagged with only a His6 tag at its C-terminus, which could be conveniently purified by affinity column. The protein could be induced for efficient expression with 0.75 mM IPTG for 8 h at 30 °C, yielding approximately 3 mg/L. In vitro biological activity …
Evaluation Of Orange Peel, An Industrial Waste, For The Production Of Aspergillus Sojae Polygalacturonase Considering Both Morphology And Rheology Effects, Ni̇han Göğüş, Bengi̇ Hakgüder Taze, Hande Demi̇r, Canan Tari, Sevcan Ünlütürk, Marcelo Fernandez Lahore
Evaluation Of Orange Peel, An Industrial Waste, For The Production Of Aspergillus Sojae Polygalacturonase Considering Both Morphology And Rheology Effects, Ni̇han Göğüş, Bengi̇ Hakgüder Taze, Hande Demi̇r, Canan Tari, Sevcan Ünlütürk, Marcelo Fernandez Lahore
Turkish Journal of Biology
Orange peel is an agroindustrial waste rich in pectin and known to be an inducer for pectinase production. The use of this low-cost substrate for the production of an industrially important enzyme, polygalacturonase (PG), can be an alternative way to turn this waste into a value-added product, contributing to the reduction of environmental waste disposal problems. Enzyme productions by fungal microorganisms are affected by environmental and nutritional factors, demanding the determination of optimum conditions for maximum enzyme production with the desired fungal morphology and broth rheology. Therefore, complex and additional carbon sources were optimized with respect to PG production by …
Impact Of Salt Stress On Photosystem Ii Efficiency And Antioxidant Enzyme Activities Of Safflower (Carthamus Tinctorius L.) Cultivars, Şeküre Çulha Erdal, Hüsnü Çakirlar
Impact Of Salt Stress On Photosystem Ii Efficiency And Antioxidant Enzyme Activities Of Safflower (Carthamus Tinctorius L.) Cultivars, Şeküre Çulha Erdal, Hüsnü Çakirlar
Turkish Journal of Biology
This study was conducted to determine the tolerance of safflower (Carthamus tinctorius L.) cultivars (Dinçer, Remzibey-05, and Yenice) against salt stress based on some physiological and biochemical parameters at the vegetative stage. Eighteen-day-old plants were subjected to salt stress [0 (control), 75, 150, 225, and 300 mM NaCl concentrations] for 12 days, which led to a significant decrease in growth parameters (stem growth, fresh weight, and relative water content) and the photosynthetic pigment contents of the safflower cultivars. The photochemical activities of photosystem II of the cultivars were negatively affected by salinity, especially at the highest concentration (300 mM). Salt …
Optimization Of E. Coli Culture Conditions For Efficient Dna Uptake By Electroporation, Irfan Ahmad, Tehseen Rubbab, Farah Deeba, Syed Muhammad Saqlan Naqvi
Optimization Of E. Coli Culture Conditions For Efficient Dna Uptake By Electroporation, Irfan Ahmad, Tehseen Rubbab, Farah Deeba, Syed Muhammad Saqlan Naqvi
Turkish Journal of Biology
Bacterial transformation is a significant breakthrough in the field of molecular biology for cloning purposes. A variety of chemical and physical methods are utilized for enhancing bacterial competence. The present study was designed, via the consolidation of chemical and physical methods, to improve competence of cells for high transformation efficiency up to 10^9 transformants/µg of DNA. LB and SOC media and their supplemented combinations with osmotic agents (sucrose and glycine) were used to prepare electrocompetent cells of E. coli DH5\alpha at temperatures of 25 and 37 °C, which were then subjected to electroporation. The results showed that cells grown in …
Effect Of Polyamines On In Vitro Anther Cultures Of Carrot (Daucus Carota L.)., Krystyna Górecka, Waldemar Kiszczak, Dorota Krzyzanowska, Urszula Kowalska, Agata Kapuscinska
Effect Of Polyamines On In Vitro Anther Cultures Of Carrot (Daucus Carota L.)., Krystyna Górecka, Waldemar Kiszczak, Dorota Krzyzanowska, Urszula Kowalska, Agata Kapuscinska
Turkish Journal of Biology
This study examines the influence of the polyamines putrescine and spermidine on the efficiency of androgenesis in anther cultures of 2 carrot cultivars, Kazan F_1 and Narbonne F_1, and the effect of putrescine on the process of plant regeneration from androgenetic embryos. In the Kazan F_1 variety, an increase in the number of obtained embryos was achieved using each of the 2 polyamines separately and in combination. In contrast, no beneficial effects of polyamines on the efficiency of androgenesis were observed in the Narbonne F_1 variety. Putrescine added to the regeneration medium increased the number of obtained plants. For embryos …
Phylogenetic Analysis And Characterization Of An Alkane-Degrading Yeast Strain Isolated From Oil-Polluted Soil, Ortansa Csutak, Tatiana Vassu
Phylogenetic Analysis And Characterization Of An Alkane-Degrading Yeast Strain Isolated From Oil-Polluted Soil, Ortansa Csutak, Tatiana Vassu
Turkish Journal of Biology
The isolation and phylogenetic analysis of new yeast strains represent an important basis for the development of practical applications in biotechnology, industry, and bioremediation. The yeast strain RG1 was isolated from oil-polluted soil and characterized using morphological observations and the API 20C AUX system. The amplified ITS1-5.8S rDNA-ITS2 region had 653 bp and the restriction profiles obtained with Cfo I, Dde I, Hae III, Hinf I, and Hpa II endonucleases showed high similarities with those from Rhodotorula glutinis reference strains. The phylogenetic tree based on the Cfo I patterns confirmed the classification of the strain RG1 as belonging to the …
Cloning, Purification, And Characterization Of A Thermophilic Ribulokinase From Anoxybacillus Kestanbolensis Ac26sari, Müslüm Tokgöz, Kadri̇ye İnan, Ali̇ Osman Beldüz, Öznur Gedi̇kli̇, Sabri̇ye Çanakçi
Cloning, Purification, And Characterization Of A Thermophilic Ribulokinase From Anoxybacillus Kestanbolensis Ac26sari, Müslüm Tokgöz, Kadri̇ye İnan, Ali̇ Osman Beldüz, Öznur Gedi̇kli̇, Sabri̇ye Çanakçi
Turkish Journal of Biology
The gene encoding ribulokinase araB from Anoxybacillus kestanbolensis AC26Sari was cloned and sequenced. The recombinant protein was expressed in Escherichia coli BL21 under the control of isopropyl-\beta-D-thiogalactopyranoside-inducible T7 promoter. The enzyme, designated as AC26RK, was purified with the MagneHis Protein Purification System. The molecular mass of the native protein, as determined by SDS-PAGE, was about 61 kDa. AC26RK was active throughout a broad pH (pH 5.0-10.0) and temperature (50-75 °C) range, and it had an optimum pH of 9.0 and optimum temperature of 60 °C. The enzyme displayed about 90%-100% of its original activities after a 30-min incubation at a …
Cloning And Expression Analysis Of 1-Deoxy-D-Xylulose-5-Phosphate Synthase Gene From The Medicinal Plant Conyza Blinii H.Lév., Rong Sun, Shan Liu, Jing-Lei Gao, Zi-Zhong Tang, Hui Chen, Cheng-Lei Li, Qi Wu
Cloning And Expression Analysis Of 1-Deoxy-D-Xylulose-5-Phosphate Synthase Gene From The Medicinal Plant Conyza Blinii H.Lév., Rong Sun, Shan Liu, Jing-Lei Gao, Zi-Zhong Tang, Hui Chen, Cheng-Lei Li, Qi Wu
Turkish Journal of Biology
Conyza blinii H.Lév. is a traditional Chinese medicinal plant that is distributed mainly in southwestern Sichuan and northern Yunnan. Its characteristic product is blinin, which has, among other properties, antigastric ulcer activity, and can serve as a quality-control standard for such medicine. The problem is that C. blinii only produces low yields of blinin. As a diterpene, blinin is likely formed by the methylerythritol phosphate pathway. While 1-deoxy-D-xylulose-5-phosphate synthase (DXS) is the first rate-limiting enzyme in diterpenoid biosynthesis, it is a switch in the pathway. The DXS gene was successfully cloned and characterized from C. blinii by homologous cloning and …
Phylogenetic Analysis Of Peste Des Petits Ruminants Virus From Outbreaks In Turkey During 2008-2012, Leyla Güler, Murat Şevi̇k, Mustafa Hasöksüz
Phylogenetic Analysis Of Peste Des Petits Ruminants Virus From Outbreaks In Turkey During 2008-2012, Leyla Güler, Murat Şevi̇k, Mustafa Hasöksüz
Turkish Journal of Biology
Peste des petits ruminants (PPR) is an important viral disease of sheep and goats and is endemic in all regions of Turkey. In this study, PPR virus infection was investigated by RT-PCR assay based on the fusion (F) gene in PPR-suspected sheep and goat samples. PPR virus RNA was detected in 65 small ruminants (51 sheep, 14 goats) from independent outbreaks during 2008-2012 in provinces in the central and Mediterranean regions and the central-west part of the Aegean region in Turkey. The virus was detected in an aborted sheep fetus sample by RT-PCR, and diagnosis was also confirmed by virus …
Triumph Or Tragedy: Progress In Cancer, Ayşe Şebnem Erenler, Hi̇kmet Geçki̇l
Triumph Or Tragedy: Progress In Cancer, Ayşe Şebnem Erenler, Hi̇kmet Geçki̇l
Turkish Journal of Biology
Cancer is probably the number one research area among all human endeavors, receiving the largest portion of science funding in most countries. This is because cancer remains one of the oldest conundrums among all human maladies. Although we now have a greater understanding of the biological and molecular basis of cancer, its diagnosis and therapy still pose great challenges. In this review, our aim is not to establish a comprehensive understanding of cancer, which is essentially impossible, but to outline, in a more provocative way, why cancer research in the pursuit of a cure did not live up to its …
Glycosylation Changes Leading To The Increase In Size On The Common Core Of N-Glycans, Required Enzymes, And Related Cancer-Associated Proteins, Sabi̇re Karaçali, Savaş İzzetoğlu, Remzi̇ye Deveci̇
Glycosylation Changes Leading To The Increase In Size On The Common Core Of N-Glycans, Required Enzymes, And Related Cancer-Associated Proteins, Sabi̇re Karaçali, Savaş İzzetoğlu, Remzi̇ye Deveci̇
Turkish Journal of Biology
Glycan parts of glycoconjugates on the surfaces of cells regulate many kinds of interactions between the cells and their immediate environments. Alterations in glycosylation on the cancer-associated glycoproteins are responsible for changes in their molecular interactions and biological functions. Glycosylation changes occur in the core and/or at the nonreducing end of the oligosaccharide chains of N-glycans. In this review, we focus on the branching of the common core structure of N-glycans, the responsible enzyme, and the extensions of some of the branches causing size increases on the surface of tumor cells. Abnormal branching, elongation of the branches, and increasing size …
Progesterone Receptor Modulators In Breast Cancer, Ronald D. Wiehle
Progesterone Receptor Modulators In Breast Cancer, Ronald D. Wiehle
Turkish Journal of Biology
Breast cancer has been treated successfully with selective estrogen receptor antagonists (SERMs) such as tamoxifen, receptor-depleting agents such as fulvestrant, and aromatase inhibitors such as anastrozole. Selective progesterone receptor modulators (SPRMs or PRMs) have not been studied as much and are currently under investigation for inhibition of mammary carcinogenesis in animal models and breast cancer prevention trials in women. They might follow tamoxifen and aromatase inhibitors in the adjuvant treatment of breast cancers with acquired resistance. These uses have not provoked ground-breaking progress or studies and PRMs do not have a high profile. Most in vitro and in vivo studies …
The Role Of Abc Transporters In Anticancer Drug Transport, Serhan Karvar
The Role Of Abc Transporters In Anticancer Drug Transport, Serhan Karvar
Turkish Journal of Biology
The main clinical problem in cancer treatment is the development of multidrug resistance. Tumors can be intrinsically drug-resistant or develop resistance to chemotherapy. Multidrug resistance can develop by diverse mechanisms including decreased rate of drug uptake, increased drug efflux, alterations in drug metabolism, mutation of drug targets, activation of DNA repair mechanisms, and evasion of apoptosis. The use of modern genomic, proteomic, bioinformatic, and systems biology approaches has resulted in a substantial increase in our ability to identify molecular mechanisms that are involved in multidrug resistance in cancer and to find drugs that may block or reverse the development of …
Multidrug Resistance In Chronic Myeloid Leukemia, Mi̇ray Ünlü, Yağmur Ki̇raz, Fatma Necmi̇ye Kaci, Mehmet Ali̇ Özcan, Yusuf Baran
Multidrug Resistance In Chronic Myeloid Leukemia, Mi̇ray Ünlü, Yağmur Ki̇raz, Fatma Necmi̇ye Kaci, Mehmet Ali̇ Özcan, Yusuf Baran
Turkish Journal of Biology
Chronic myeloid leukemia (CML) is characterized by the accumulation of Philadelphia chromosome-positive (Ph+) myeloid cells. Ph+ cells occur via a reciprocal translocation between the long arms of chromosomes 9 and 22 resulting in constitutively active Bcr-abl fusion protein. Tyrosine kinase inhibitors (TKIs) are used against the kinase activity of Bcr-abl fusion protein for the effective treatment of CML. However, the development of drug resistance, directed by different genetic mechanisms, is the major problem of clinical applications of TKIs. These mechanisms include mutations in the TKI binding site of Bcr-abl, overexpression of Bcr-abl, overexpression of ATP binding cassette transporters, aberrant ceramide …
Noncoding Rnas And Cancer, Hesna Begüm Akman Tuncer, Ayşe Eli̇f Erson Bensan
Noncoding Rnas And Cancer, Hesna Begüm Akman Tuncer, Ayşe Eli̇f Erson Bensan
Turkish Journal of Biology
New and diverse groups of noncoding RNAs are beginning to be discovered. These noncoding RNAs are grouped based on their sizes, genomic positions, or distinctive functions ranging from the regulation of chromatin structure and gene expression to genome stability maintenance. Among noncoding RNAs, microRNAs are the best studied and understood small RNAs with direct and indirect roles in normal and in cancer cells. Given the high rate of transcription from noncoding parts of the genome, other noncoding elements are also of great interest. It is also of interest to understand that there may be interesting cases of crosstalk and/or coregulation …
Cancer Stem Cells: Emerging Actors In Both Basic And Clinical Cancer Research, Di̇dem Karakaş, Buse Cevatemre, Engi̇n Ulukaya
Cancer Stem Cells: Emerging Actors In Both Basic And Clinical Cancer Research, Di̇dem Karakaş, Buse Cevatemre, Engi̇n Ulukaya
Turkish Journal of Biology
Cancer stem cells (CSCs) are a small subset of cancer cells within a tumor that are responsible for tumorigenesis and contribute to drug resistance. The CSC displays an anchorage-independent survival, active DNA-repair capacity, and relative quiescence and is capable of self-renewing and maintaining tumor growth and heterogeneity. At the molecular level, there are several signaling pathways (e.g., Wnt/Beta-catenin, Notch, and Hedgehog) to control CSC properties and alteration of these pathways has been recognized as an essential step for CSC transformation. Emerging evidence suggests that CSCs are clinically relevant. These cells are resistant to conventional chemotherapy and radiation treatment. Therefore, CSCs …
Identification Of New Genes Required For The Maintenance Of Chromosome Integrity In Drosophila Melanogaster, Francesca Ceprani, Franco Spirito, Roberto Piergentili
Identification Of New Genes Required For The Maintenance Of Chromosome Integrity In Drosophila Melanogaster, Francesca Ceprani, Franco Spirito, Roberto Piergentili
Turkish Journal of Biology
Although genome-wide RNA interference (RNAi) screens for mitotic genes are not new in the literature, most of them lack the cytological characterization of the cell karyotype as for chromosome integrity. Here, the effects of RNAi on chromosome structure in S2 cultured cells of Drosophila melanogaster were analyzed. The cytological phenotype of 1132 genes selected by coexpression with known mitotic genes was scored. Cytological and statistical analysis of the treated cells allowed the identifying of 81 loci whose inactivation brings a level of chromosome breakage significantly higher than in the control. Many of the genes characterized in the present work had …
Loss Of Heterozygosity In Ing3 And Ing5 Genes In Breast Cancer, Esra Gündüz, Gökhan Nas, Muradi̇ye Acar, Eyyüp Üçtepe, Mi̇kdat Bozer, Murat Öznur, Reyhan Bayrak, Mehmet Gündüz
Loss Of Heterozygosity In Ing3 And Ing5 Genes In Breast Cancer, Esra Gündüz, Gökhan Nas, Muradi̇ye Acar, Eyyüp Üçtepe, Mi̇kdat Bozer, Murat Öznur, Reyhan Bayrak, Mehmet Gündüz
Turkish Journal of Biology
The tumor suppressor genes (TSGs) ING3 and ING5, members of the inhibitor of growth gene family, are effective in inhibition of cell growth and induction of apoptosis. However, in many cancer types, one of the alleles of a TSG is lost through carcinogenesis, while the remaining allele is usually inactivated through a process called loss of heterozygosity (LOH). Previous studies in head and neck cancer revealed that allelic loss and reduced expression is a common pattern of ING gene family members. Fifty paraffin-embedded breast cancer tissues were analyzed by polymerase chain reaction and denatured-polyacrylamide gel electrophoresis for LOH status. The …
Analysis Of “Bimbam”, A Novel Glucocorticoid-Induced Bh3-Only Transcript In Cell Lines And Children With Acute Lymphoblastic Leukemia, Muhammad Mansha, Muhammad Wasim, Ali Raza Awan, Asma Abdul Latif
Analysis Of “Bimbam”, A Novel Glucocorticoid-Induced Bh3-Only Transcript In Cell Lines And Children With Acute Lymphoblastic Leukemia, Muhammad Mansha, Muhammad Wasim, Ali Raza Awan, Asma Abdul Latif
Turkish Journal of Biology
Glucocorticoids (GCs) induce apoptosis and cell cycle arrest in lymphoid cells and are fundamental components of therapeutic regimens of acute lymphoblastic leukemia (ALL). We previously identified a panel of GC-induced candidate genes in children with ALL and in other biological systems using whole genome expression profiling. Of those, a novel transcript from the BCL2L11/Bim locus, named \"Bimbam\", was functionally analyzed in the current study. The postulated Bimbam mRNA consists of the 5' portion of Bim including the BH3-containing exon 8 and the 3' portion of Bam, a small 2-exon gene embedded in the BCL2L11/Bim locus. The expression and GC induction …
Induction Of Apoptosis In The Cervical Cancer Cell Line Hela By A Novel Metabolite Extracted From The Fungus Aspergillus Japonicus Saito, Apoorva Prabhu, Prerana Venkat, Bharath Gajaraj, Varalakshmi Kilingar Nadumane
Induction Of Apoptosis In The Cervical Cancer Cell Line Hela By A Novel Metabolite Extracted From The Fungus Aspergillus Japonicus Saito, Apoorva Prabhu, Prerana Venkat, Bharath Gajaraj, Varalakshmi Kilingar Nadumane
Turkish Journal of Biology
Natural bioactive compounds have been found superior to chemical compounds for use in pharmaceutical applications. Such natural compounds include biologically active compounds present as a part of fungal metabolism that originate through different biochemical pathways and contain different structural groups like benzopyranones, phenols, toxins, and steroids. One such novel compound is a secondary metabolite extracted from the filamentous fungus Aspergillus japonicus Saito. The compound exhibited anticancer properties and was found to be harmless to normal human lymphocytes. The metabolites were separated by thin layer chromatography and screened for their cytotoxic potential through 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay in the cervical cancer …
Cancer Chemopreventive Effect Of Dietary Zataria Multiflora Essential Oils, Abolfazl Dadkhah, Faezaeh Fatemi, Mohammad Reza Mohammadi Malayeri, Azadeh Rasooli
Cancer Chemopreventive Effect Of Dietary Zataria Multiflora Essential Oils, Abolfazl Dadkhah, Faezaeh Fatemi, Mohammad Reza Mohammadi Malayeri, Azadeh Rasooli
Turkish Journal of Biology
Zataria multiflora Boiss., with the common name Avishan-e-Shirazi, is native to Iran. This herb has been found to possess varied pharmacological properties. In the present study, for the first time, colon chemopreventive effects of Z. multiflora essential oils (0.01% and 0.1% in the diet) in rats treated with 1,2-dimethylhydrazine (DMH) were demonstrated. For this purpose, the oxidative stress/antioxidant parameters (lipid peroxidation, glutathione, superoxide dismutase, catalase, and ferric reducing ability of plasma) concomitant with xenobiotic metabolizing enzymes (CYP450 and GST) were considered. Moreover, the colonic Beta-catenin protein was examined in colon tissues followed by histopathological analysis. The results showed that the …
Anticancer Activities And Mechanism Of Action Of 2 Novel Metal Complexes, C_{16}H_{34}N_{8}O_{5}Ag_{2}Cd And C_{11}H_{16}N_{7}O_{2}Ag_{3}Ni, Ali̇ Aydin, Nesri̇n Korkmaz, Şaban Teki̇n, Ahmet Karadağ
Anticancer Activities And Mechanism Of Action Of 2 Novel Metal Complexes, C_{16}H_{34}N_{8}O_{5}Ag_{2}Cd And C_{11}H_{16}N_{7}O_{2}Ag_{3}Ni, Ali̇ Aydin, Nesri̇n Korkmaz, Şaban Teki̇n, Ahmet Karadağ
Turkish Journal of Biology
The discovery of anticancer activity in cisplatin triggered the development of novel drugs containing metals such as platinum or ruthenium. Extremely diverse structural chemistry and the interaction of metal complexes with biomolecules resulted in the exploration of novel metal complexes with drug potential. In the present study, the anticancer and cytotoxic activities and the mechanisms of action were investigated for C_{16}H_{34}N_{8}O_{5}Ag_{2}Cd (AN1) and C_{11}H_{16}N_{7}O_{2}Ag_{3}Ni (AN7), 2 newly synthesized dicyanidoargentate(I) complexes. The anticancer and cytotoxic activities of AN1 and AN7 on several cancer cell lines were tested by cell proliferation and cytotoxic activity assays, respectively. The apoptotic and replication inhibitory potentials …
A Revision Of Centaurea Sect. Centaurea (Asteraceae) From Iran, Massoud Ranjbar, Kazem Negaresh
A Revision Of Centaurea Sect. Centaurea (Asteraceae) From Iran, Massoud Ranjbar, Kazem Negaresh
Turkish Journal of Botany
A taxonomic review of Centaurea L. sect. Centaurea (Asteraceae) in Iran was carried out. Seven taxa are recognized and 1 of them is described as a new species: Centaurea joharchii Ranjbar & Negaresh. This new species has been described and illustrated from Khorasan Province, SE Iran. A new combination is proposed: C. kermanshahensis (Wagenitz) Ranjbar & Negaresh. In addition, C. aggregata Fisch. & C.A.Mey. ex DC. subsp. aggregata is typified and C. diffusa Lam. is reported here as a new record for Iran. Finally, a key to all species of the section Centaurea in Iran is provided.
Morphological And Biometrical Comparisons Of The Baculum In The Genus Nannospalax Palmer, 1903 (Rodentia: Spalacidae) From Turkey With Consideration Of Its Taxonomic Importance, Teoman Kankiliç, Tolga Kankiliç, Peri̇nçek Seçki̇n Ozan Şeker, Erkut Kivanç
Morphological And Biometrical Comparisons Of The Baculum In The Genus Nannospalax Palmer, 1903 (Rodentia: Spalacidae) From Turkey With Consideration Of Its Taxonomic Importance, Teoman Kankiliç, Tolga Kankiliç, Peri̇nçek Seçki̇n Ozan Şeker, Erkut Kivanç
Turkish Journal of Zoology
The morphological variability of the baculum (os penis) of 147 adult specimens of species in the genus Nannospalax from 58 localities in Turkey was examined using morphological and numerical taxonomic methods. Significant differences among all of the Turkish species in the genus were determined by morphological and biometrical comparison of the bacula, and the results of this study showed that N. nehringi and N. xanthodon are separate species and that the names are not synonyms. Additionally, because the central Anatolian mole rat populations that were classified by previous studies as members of N. nehringi or N. xanthodon had highly different …
Gan Nanostructuring For The Fabrication Of Thin Membranes And Emerging Applications, Ion Tiginyanu, Veaceslav Ursaki
Gan Nanostructuring For The Fabrication Of Thin Membranes And Emerging Applications, Ion Tiginyanu, Veaceslav Ursaki
Turkish Journal of Physics
We present a review of technological methods developed in recent years for the purpose of gallium nitride nanostructuring, with the main focus on fabrication of thin GaN membranes. In particular, we report on traditional methods of wet etching undercutting for membrane manufacturing, technologies applied for the fabrication of photonic crystal structures based on GaN nanomembranes, double side processing, and surface charge lithography. Prospects of membrane applications in photonic devices, sensors, and microoptoelectromechanical and nanoelectromechanical systems are discussed, taking into account the advantageous piezoelectric, optical, and mechanical properties of GaN and related III-V nitride materials.
The Expression Of Egfr, Cerbb2, P16, And P53 And Their Relationship With Conventional Parameters In Squamous Cell Carcinoma Of The Larynx, Hülya Şi̇mşek, Ünsal Han, Bi̇nnur Önal, Gülçi̇n Şi̇mşek
The Expression Of Egfr, Cerbb2, P16, And P53 And Their Relationship With Conventional Parameters In Squamous Cell Carcinoma Of The Larynx, Hülya Şi̇mşek, Ünsal Han, Bi̇nnur Önal, Gülçi̇n Şi̇mşek
Turkish Journal of Medical Sciences
To investigate the expression of epidermal growth factor receptor¬-HER1 (EGFR), cerbB2 (HER2), p16, and p53, as well as the relationship of the expression of these genes with conventional parameters in squamous cell carcinoma (SCC) of the larynx. Materials and methods: Samples from 92 cases of diagnosed laryngeal SCC between 2001 and 2011 from the Pathology Department of Ministry of Health Ankara Dışkapı Yıldırım Beyazıt Teaching & Research Hospital were studied by immunohistochemistry using EGFR, cerbB2, p16, and p53 antibodies. Results: An increase in the TNM stage and pathological tumor size status correlated with an increase in EGFR and cerbB2 expression. …
Immunohistochemical Investigation Of Galectin-3 In The Skin Of Mice Applied With Origanum Hypericifolium Essential Oil And Irradiated With Ultraviolet B, Pinar İli̇, Nazan Keski̇n
Immunohistochemical Investigation Of Galectin-3 In The Skin Of Mice Applied With Origanum Hypericifolium Essential Oil And Irradiated With Ultraviolet B, Pinar İli̇, Nazan Keski̇n
Turkish Journal of Medical Sciences
To demonstrate galectin-3-immunoreactivity in the undiluted essential oil of Origanum hypericifolium when applied to the ultraviolet B (UVB) irradiated skin of mice. Materials and methods: Female BALB/c mice were allocated to 4 groups, each comprising 6 mice (Group 1: control; Group 2: UVB irradiated control; Group 3: undiluted O. hypericifolium essential oil applied; Group 4: undiluted O. hypericifolium essential oil applied before UVB irradiation). One week prior to UVB irradiation, the undiluted O. hypericifolium essential oil was applied to the shaved dorsal skin of mice 3 times a week. Subsequently, the mice were irradiated 3 times per week with UVB …
Discovering Missing Heritability And Early Risk Prediction For Type 2 Diabetes: A New Perspective For Genome-Wide Association Study Analysis With The Nurses' Health Study And The Health Professionals' Follow-Up Study, Hüsametti̇n Gül, Yeşi̇m Aydin Son, Cengi̇zhan Açikel
Discovering Missing Heritability And Early Risk Prediction For Type 2 Diabetes: A New Perspective For Genome-Wide Association Study Analysis With The Nurses' Health Study And The Health Professionals' Follow-Up Study, Hüsametti̇n Gül, Yeşi̇m Aydin Son, Cengi̇zhan Açikel
Turkish Journal of Medical Sciences
Despite the rise in type 2 diabetes prevalence worldwide, we do not have a method for early risk prediction. The predictive ability of genetic models has been found to be little or negligible so far. In this study, we aimed to develop a better early risk prediction method for type 2 diabetes. Materials and methods: We used phenotypic and genotypic data from the Nurses' Health Study and Health Professionals' Follow-up Study cohorts and analyzed them by using binary logistic regression. Results: Phenotypic variables yielded 70.7% overall correctness and an area under the curve (AUC) of 0.77. With regard to genotype, …
The Taxonomic Status And Geographic Distribution Of The European Hare (Lepus Europaeus Pallas, 1778) In Turkey (Mammalia: Lagomorpha), Yasi̇n Demi̇rbaş, İrfan Albayrak
The Taxonomic Status And Geographic Distribution Of The European Hare (Lepus Europaeus Pallas, 1778) In Turkey (Mammalia: Lagomorpha), Yasi̇n Demi̇rbaş, İrfan Albayrak
Turkish Journal of Zoology
This study was based on 125 specimens of hares collected from 61 different localities in Turkey between 2006 and 2010. We present diagnostic characters, pelage coloration, external, cranial and phallic measurements, skull and phallus features, hair structure, and collection localities of hares from Turkey. Additionally, we analyze morphometric variations of 5 regional populations according to the physiography/orography of the study area. Among the morphometric variables, 10 characters (weight, tail length, basal length, condylobasal length, rostral breadth, height of braincase, foramen incisiva length, occipitonasal length, profile length, and mandible length) are found to be significantly different between the populations (ANOVA, P < 0.01). Principal component analysis of 22 morphometric measurements is performed, and 71.56% of total variance is explained through 5 principle components. The Thracian specimen is distinguished from other populations on the first 2 canonical discriminant functions and the cluster dendrogram. The hair structure, as examined by scanning electron microscope, is found to be flattened and imbricate. Our Anatolian specimens are discussed at the subspecies level, comparing them to the relevant literature, and it is concluded that Lepus europaeus in Anatolia is represented by only one subspecies, Lepus europaeus syriacus.
Morphological Examination Of The Resting Egg Structure Of 3 Cladoceran Species [Ceriodaphnia Quadrangula (O. F. Müller, 1785), Daphnia Longispina (O. F. Müller, 1776), And D. Magna Straus, 1820], Murat Kaya, Sevi̇l Erdoğan
Morphological Examination Of The Resting Egg Structure Of 3 Cladoceran Species [Ceriodaphnia Quadrangula (O. F. Müller, 1785), Daphnia Longispina (O. F. Müller, 1776), And D. Magna Straus, 1820], Murat Kaya, Sevi̇l Erdoğan
Turkish Journal of Zoology
Morphological characteristics of the resting egg, which is important to ensure the continuity of generations, were examined to understand if there were morphologically significant differences among 3 cladoceran species. Resting eggs floating on the water surface were collected by a plankton net with a mesh size of 100 \mum from Mamasın Dam Lake in November 2012 and were left to dry at room temperature in the laboratory. In this study, the size, shape, and color of the ephippium and the size of the egg/eggs enclosed in the ephippium were comparatively analyzed by stereomicroscope and scanning electron microscope. It was observed …