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The First Documented Case Of Melanism In Sciurus Anomalus, Recorded In Türkiye, Burak Akdağ, Balkan Mega

Turkish Journal of Zoology

This study reports the first documented case of melanism in the Caucasian squirrel (Sciurus anomalus) from Türkiye. While melanism has been documented in 12 other species within the Sciurus genus, it has not previously been recorded in S. anomalus. The observation was made during a herpetological field survey in Erzincan Province, Türkiye, where a melanistic specimen was photographed in a mixed habitat comprising natural vegetation and cultivated land. In mammals, melanism is widely regarded as an adaptive trait, potentially conferring advantages such as improved thermoregulation in colder climates and enhanced crypsis in shaded forest environments. This novel observation not only …

Expression Of Concern: Characterization Of Tfiie-Regulated Genes By Transcriptomeanalysis, Serdar Baysal

Turkish Journal of Biology

The Editors of Turkish Journal of Biology wish to issue an Expression of Concern regarding the article entitled: “Characterization of TFIIE-regulated genes by transcriptome analysis” by Serdar Baysal published on 20.12.2024. Following the publication of this article, concerns have been raised regarding• Potential violations of academic ethical standards in the published study• Potential intellectual property infringement, including plagiarism• An academic sanction reportedly imposed on the author by the affiliated university following an institutional disciplinary investigation. An investigation is currently underway to assess the validity of these concerns. In accordance with the guidelines of the Committee on Publication Ethics (COPE), and …

Discovery And Characterization Of Selective Lipase-Inhibiting Polyheterocyclic Derivatives: A Combined In Silico And In Vitro Study, Madjda Benguechoua, Mebarka Imane Benguechoua, Khedidja Benarous, Houssem Boulebd, Ibtissem Kadi, Ari̇f Mermer, Yakup Şi̇ri̇n, Alaeddine Kaouka, Mohamed Yousfi

Turkish Journal of Biology

Background/aim: Obesity has become a global health crisis with an increasing prevalence, necessitating the search for effective therapies. Schiff base derivatives, known for their broad pharmacological activities, have gained attention as potential antiobesity agents. This study aimed to investigate the lipase inhibitory potential of novel Schiff base derivatives and assess their drug-like properties through in vitro assays and in silico methods. Materials and methods: The lipase inhibitory activity of synthesized Schiff base derivatives was evaluated using in vitro assays, with IC50 values determined for each compound. Additionally, in silico ADMET predictions (absorption, distribution, metabolism, excretion, and toxicity), molecular docking studies, …

Butyrylcholinesterase (Bche) Downregulation In Taxane Resistance: Implications For Prostate Cancer, Buse Cevatemre, Arda Işiklar, İpek Bulut, Ezgi̇ Karyemez, Hamzah Syed, Ceyda Açilan

Turkish Journal of Biology

Background/aim: Despite advancements in chemotherapeutic strategies, drug resistance remains a major barrier to effective cancer treatment. While primary prostate cancers (PC) can be treated with surgery and radiotherapy, treatment options for recurrent PC are limited. Upon progression to the castration-resistant (CR) phase, therapies rely on taxanes (chemotherapeutic drugs) like docetaxel (Dtx) and cabazitaxel (Cbz); however, resistance to taxanes is common in CRPC, highlighting the importance of identifying underlying molecular mechanisms or targets in resistant cells.Materials and methods: In transcriptome (RNA sequencing) analyses comparing taxane-resistant PC cells (resistant to both Dtx and Cbz) with parental (nonresistant, sensitive) cells, butyrylcholinesterase (BChE) was …

Proteomic Profiling Of Escherichia Coli Cytoplasmic Proteins Under Sublethal Boric Acid Stress, Beki̇r Çöl, Begüm Hazar Çi̇ftçi̇, Merve Sezer Kürkçü, Esra Di̇bek

Turkish Journal of Biology

Background/aim: Boron is an essential micronutrient for plants and certain bacteria, where it plays critical roles in cellular processes at low concentrations. However, elevated levels of boron-containing compounds, such as boric acid, exhibit antimicrobial toxicity. Although the physiological effects of boric acid on bacteria have been partially characterized, its proteome-wide impacts remain poorly elucidated. This study employs a 2D-PAGE-based proteomic approach to investigate how sublethal boric acid stress alters the cytoplasmic proteome of Escherichia coli BW25113. Materials and methods: E. coli BW25113 cultures were grown to mid-log phase in tryptic soy broth (TSB) and exposed to 70 mM boric acid …

Screening Of Ccdc43 Molecular Partners By Bioid2-Based Proximity Labeling, Merve Tuzlakoğlu Öztürk

Turkish Journal of Biology

Background/aim: CCDC43 (coiled-coil domain containing protein 43) is a eukaryotic protein that contains alpha-helical domains in its structure, consistent with the family to which it belongs. It is predominantly located in the cytosol of the cell. CCDC43 protein has been shown to play a role in cell proliferation, invasion, metastasis, and epithelial–mesenchymal transition in gastric and colorectal cancer types. The fundamental function and cellular interaction network of this protein, which is known to have varying expression levels in various cancer types, has not yet been fully elucidated. Here, we conducted a proximity-dependent biotin identification (BioID2) screening approach for CCDC43 to …

Fda-Approved Drugs As Potential Covalent Inhibitors Of Key Sars-Cov-2 Proteins: An In Silico Approach, Murat Seri̇lmez, Anwar Abuelrub, İsmai̇l Erol, Serdar Durdaği

Turkish Journal of Biology

Background/aim: The COVID-19 pandemic caused by SARS-CoV-2 necessitated rapid development of effective therapeutics, prompting this study to identify potential inhibitors targeting key viral and host proteins: RNA-dependent RNA polymerase (RdRp), main protease (Mpro), transmembrane serine protease 2 (TMPRSS2), and angiotensin-converting enzyme 2 (ACE2). Methods: We used covalent docking and molecular dynamics (MD) simulations to screen FDA-approved compounds against these targets using diverse covalent reaction mechanisms. Top-ranking compounds underwent further evaluation through MD simulations to assess binding stability and conformational dynamics. Results: Several promising drug repurposing candidates were identified: bremelanotide, lanreotide, histrelin, and leuprolide as potential RdRp inhibitors; azlocillin, cefiderocol, and …

Antiinflammatory Effects Of Cucurbitacins And Sorafenib In Hepg2 Cells By Modulating The Iκb/Nf-Κb/Cox-2 Pathway Through Akt Signaling, Muhammed Mehdi̇ Üremi̇ş, Yusuf Türköz, Nuray Üremi̇ş

Turkish Journal of Biology

Aim: Cucurbitacins possess antitumor, antiproliferative, and antiinflammatory properties. This study aims to examine the antiinflammatory effects of CuD, CuI, and CuE on NF-κB, iNOS, COX-2, and Akt and compare their cytotoxic and antiinflammatory effects on HepG2 cells with sorafenib, the primary chemotherapeutic agent used in HCC treatment. Methods: Cytotoxic effects of cucurbitacins and sorafenib on HepG2 cells were evaluated using MTT and LDH assays, along with Annexin V, MMP, and comet assays. Levels of proteins related to the Akt/NF-κB pathway and COX-2, iNOS, and NO were also measured. Results: Our study showed that CuD, CuI, CuE, and sorafenib have antiproliferative …

Novel Mrsa-Targeting Phage Metb16: Genomic Features, Structural Insights, And Therapeutic Applications, Berna Erdoğdu, Senanur Dokuz, Görkem Güngör, Wei Lin, Yigang Tong, Tüli̇n Özbek

Turkish Journal of Biology

Background/aim: Recent reports have indicated that multidrug-resistant strains of S. aureus, including methicillin-resistant strains, may pose a significant threat to public health and global economic stability. Materials and methods: In this study, we present the isolation and comprehensive characterization of a novel phage, derived from clinically isolated MRSA strains. Results: MetB16 exhibited an incubation period of approximately 20 min, a lysis period of around 45 min, and a burst size of 127 Plaque Forming Units (PFU)/cell. The phage demonstrated remarkable biological stability across a pH spectrum of 4.0–9.0 and maintained integrity within a temperature range of 37 and –80 °C. …

Cover And Contents

Turkish Journal of Biology

No abstract provided.

Insights Into Therapeutic Discovery Through The Kelch Domain Structure Of Keap1 At Ambient Temperature, Merve Yilmaz, Belgi̇n Sever, Yi̇ği̇t Kutlu, Mehmet Gül, Ceren Okuducu, Serra Tavli, Masami Otsuka, Mikako Fujita, Turkan Hali̇loğlu, Hali̇li̇brahi̇m Çi̇ftçi̇, Hasan Demi̇rci̇

Turkish Journal of Biology

Background/aim: The Kelch-like-ECH associated protein 1 (Keap1) is an integral component of the E3-ubiquitin ligase complex, which binds to Nuclear factor erythroid 2-related factor 2 (Nrf2) and facilitates its degradation by the 26S proteasome. The Kelch domain of Keap1, composed of six repeated structural motifs, plays a key role in this interaction. This study aims to investigate the dimeric structure of the Keap1 Kelch domain at ambient temperature and to examine its implications for conformational dynamics, particularly in relation to the DMF and Nrf2 binding sites.Materials and methods: The dimeric crystal structure of the Keap1 Kelch domain was determined at …

The Effects Of Hsa-Mir-26a-5p On Cell Proliferation, Migration, And Pi3k Inhibitor Sensitivity In Metformin-Resistant Triple Negative Breast Cancer Cells, Şahi̇ka Cingir Köker, Senem Noyan, Banu Yalçin, İrem Doğan Turaçli

Turkish Journal of Biology

Background/aim: Metformin is commonly used to manage type 2 diabetes (T2D) and is being investigated for its potential antiproliferative effects in cancer, particularly in patients with both T2D and malignancies. Drug resistance can develop with any therapeutic agent, and metformin is no exception. As we showed in our previous study, metformin-resistant MDA-MB-468 (MET-R) cells exhibited an EMT-like phenotype. Many transcription factors, as well as miRNAs, can contribute to this altered phenotype. Our current study identifies the contribution of hsa-miR-26a-5p expression to the previously observed phenotype. Materials and methods: By utilizing bioinformatic tools, we identified hsa-miR-26a-5p, whose expression was significantly altered …

Effects Of Commiphora Myrrha Resin Extract/Nanosilver On Immune Cells, Pathogen, And Breast/Colon Cancer Cell Line Growth, Mohammad Y. Alshahrani, Essam H. Ibrahim, Abeer S. Alahmari, Mona Kilany, Ramadan Taha, Haitham I. El-Mekkawy, Amr Ahmed El-Arabey, Ahmed Ezzat Ahmed

Turkish Journal of Agriculture and Forestry

Commiphora myrrha grows in various places of the world and is used for many purposes. The objectives of this study were to examine the biological influences of C. myrrha resin extract (MRE) alone or with its biogenic nanosilver on microbial, immune, and cancer cell growth. C. myrrha resin was boiled to prepare the MRE. Functional groups in the MRE were explored using Fourier-transform infrared spectroscopy (FTIR). MRE was used to synthesize nanosilver that was characterized using an ultraviolet-visible (UV-Vis)-spectrophotometer and X-ray diffraction. In vivo experiments included the untreated group (G1) and MRE-orally treated group (G2). Cancer cell lines, HCT-116 (colon) …

Antiinflammatory Mechanisms Of Barley-Based Functional Foods Beyond Diabetes Management, Hafiz Ghulam Muhu Din Ahmed, Adnan Noor Shah, Muhammad Ahtasham Mushtaq, Xiaomeng Yang, Jiazhen Yang, Xia Li, Li’E Yang, Xiaoying Pu, Yawen Zeng

Turkish Journal of Agriculture and Forestry

This review article investigated the antiinflammatory properties of barley, emphasizing its benefits beyond diabetes management. Barley, historically valued for its nutritional and medicinal properties, is rich in bioactive compounds such as beta-glucans, phenolic acids, and flavonoids. These compounds are known for their significant antioxidant and antiinflammatory activities. This study highlights the multifaceted mechanisms through which barley reduces systemic inflammation, including the enhancement of gut microbiota composition, the production of beneficial short-chain fatty acids, and the modulation of immune responses. Beta-glucans in barley lower cholesterol, and regulate glucose levels, while phenolic acids and flavonoids inhibit proinflammatory enzymes and cytokines, thereby reducing …

Comprehensive Characterization Of Purified Naringinase: Effect On Naringin Content, Antioxidant Activity, Phenolic Profile, And Grapefruit Juice Quality, Arzu İmece, Memnune Şengül, Bülent Çeti̇n, Ömer İrfan Küfrevi̇oğlu, Arzu Öztürk Kesebi̇r

Turkish Journal of Agriculture and Forestry

Bitterness arising from naringin is a problem in citrus juices, especially grapefruit juice, in terms of consumer preference. Naringinase enzyme is used to eliminate the bitterness. In this study, naringinase was extracellularly extracted, isolated, and characterized from an Aspergillus niger strain in different media. The extracted enzyme was added to grapefruit juice at different concentrations (0.1%, 0.5%, 1%) (0.078, 0.39 and 0.78 EU) and stored at different temperatures (25, 35, and 45 °C) for 5 h. At the end of the first and fifth h, the amount of naringin, physicochemical properties, phenolic profiles, and antioxidant activities of the grapefruit juice …

Cover And Contents

Turkish Journal of Agriculture and Forestry

No abstract provided.

Application Of Vermicompost Extract To Improve The Phytochemical Composition Of Berry Fruits, Jelena Tomić, Žaklina Karaklajić-Stajić, Marijana Pešaković, Svetlana M. Paunović, Boris Rilak, Maja Mikulic-Petkovsek, Metka Hudina, Robert Veberic, Nesi̇be Ebru Kafkas, Sezai̇ Erci̇şli̇, Jerneja Jakopic

Turkish Journal of Agriculture and Forestry

The growing market demand for environmentally friendly products for plant nutrition has led to the development of new fertilizers, particularly liquid compost-based products such as teas, extracts, and leachates. The aim of this research was to compare the effect of chemical fertilization (CF) and its combination with liquid fertilizer based on vermicompost and beneficial microorganisms (CF + VP) on the phytochemical profile of strawberry (Senga Sengana), blackberry (Čačanska Bestrna) and blueberry (Aurora). The results showed that CF + VP positively affected fruit weight (8.8 g), soluble solids (8.9°Bx), total sugars (65.5 g/kg FW), and the sum of all phenolic groups …

Green Biosynthesis Of Cobalt Oxide Nanoparticles Using Saccharum Munja Leaf Extract As A Catalyst For Callus Induction In Carnation (Dianthus Caryophyllus L.) Plants, Ishtiaq Ahmad, Sameed Arshad Chaudhry, Maryam Maryam, Aysha Arif Chahel, Riaz Ahmad, Mehmet Ramazan Bozhüyük, İbrahi̇m Bozkurt, Magda Abdel-Rahman, Konstantin Korolev

Turkish Journal of Agriculture and Forestry

The common name of a wild grass native to Pakistan with both edible and medicinal properties is Saccharum munja Roxb. (S. munja). Prior research has investigated various plant species for the green biosynthesis of nanoparticles to circumvent issues related to their physical and chemical production. This study presents the first evidence of synthesizing cobalt oxide nanoparticles (Co3O4NPs) using S. munja leaf extract (SMLE) as both a reducing and a capping agent. This study investigated their ability to induce in vitro callus formation in Dianthus caryophyllus L. (carnation). In this study, Co3O4NPs were synthesized using varying quantities of SMLE to achieve …

Precision Crop Yield Prediction Model Based On Deep Learning And Multimodal Data Fusion, Zijin Mo, Yanxiong Wu

Turkish Journal of Agriculture and Forestry

More precise crop yield prediction methods are essential in advancing precision agriculture, ensuring food security, and promoting sustainable agricultural practices. Deep learning technologies have significantly improved prediction accuracy by allowing the analysis of large-scale agricultural datasets. However, existing approaches still face challenges in effectively integrating multisource data, such as meteorological, soil, and remote sensing information, and optimizing model parameters. To address these issues, this study introduces TCGNet, a novel deep learning architecture that combines a time convolutional network (TCN), convolutional long short-term memory (ConvLSTM), and the grey wolf optimization (GWO) algorithm. The TCN is employed for time series analysis, ConvLSTM …

In Vitro Regeneration Potential Of Pistacia Integerrima And Pistacia Khinjuk Rootstocks: A Modeling Approach For Optimal Medium Formulation, Heydem Eki̇nci̇, Beki̇r Erol Ak

Turkish Journal of Agriculture and Forestry

Micropropagation involves the development of whole plants from small meristematic tissues by culturing them in vitro under aseptic conditions on a nutrient medium. However, identifying a single nutrient medium suitable for propagating Pistacia, a recalcitrant species, remains challenging. While some species exhibit good growth on Murashige and Skoog (MS) medium, Pistacia species generally yield insufficient results. To address this, a five-dimensional experimental design was developed using Design- Expert software (Stat-Ease Inc., Minneapolis, MN, USA). Thirty-three experimental databases were generated by the software using the modified I-optimal criterion. MS medium served as the control treatment. A response surface model (RSM) employing …

In Vivo Emergence And Seedling Growth Of Ornamental Pepper Seeds Under Diatomaceous Earth Treatments, Deni̇z Hazar

Turkish Journal of Agriculture and Forestry

Propagation by seeds is very useful in ornamental horticulture, especially for flowering plant production. Seed germination and seedling growth are the most sensitive plant developmental stages and, in nurseries, are under the influence of many biotic and abiotic stress factors. Diatomaceous earth is made from the fossilized remains of tiny aquatic organisms called diatoms, and diatomaceous earth as supplemental Si has been shown to be beneficial for plant growth, flowering, and nutrient content under both well-watered and water-stressed conditions. This study aimed to determine the effects of different methods and doses of Si-containing diatomite on in vivo seed emergence and …

A Comprehensive Review Of Fermentation Technologies In Food Processing: From Traditional To Cutting Edge, Pragati Singh, Niharika Arya, Shalini Sharma, Ankita Sharma, Prasad Rasane, Supriya Singh Gaur, Sawinder Kaur, Mahendra Gunjal, Hasan Kiliçgün, Jyoti Singh

Turkish Journal of Agriculture and Forestry

Fermentation technologies play crucial roles in food processing, offering various advantages, including enhanced flavor profiles, extended shelf life, and improved nutritional qualities. This paper provides a comprehensive overview on the major types of fermentation as well as effects of various factors such as substrate composition, temperature, pH, oxygen availability, and microbial strain selection on the process. Despite its widespread application, traditional fermentation processes face limitations related to yield optimization, contamination risks, and process consistency. Recent advancements have significantly enhanced fermentation efficiency, product quality, and scalability, ultimately expanding the applications beyond food and beverage production into pharmaceuticals, nutraceuticals, biofuels, and waste …

Enhanced And Proficient Chitosan Membranes Embedded With Polyaniline-Tio2 Core-Shell Nanocomposites For Fuel-Cell Hydrogen Storage, Mallikarjunagouda Patil, Sridhar N. Mathad, Arun Y. Patil, Abdulaziz Abdulah Al-Kheraif, Sachin Naik, Sajith Vellapally

Turkish Journal of Chemistry

This study investigates the preparation and properties of aniline polymerized in situ onto a nanosized TiO2 surface to form core-shell nanoparticles at ambient temperatures. The in situ polymerization of aniline to polyaniline (PANI), in conjunction with the utilization of an anionic surfactant, was employed in this investigation. The prepared PANI-TiO2 core-shell nanoparticles were integrated with chitosan at a gravimetric ratio and cast as core-shell nanocomposite membranes. The nanocomposites were subjected to structural analysis using Fourier transform infrared spectroscopy and X-ray diffraction patterns. The surface morphologies of the PANI and its nanocomposites were analyzed using scanning electron microscopy. Direct current conductivity …

Determination Of P53 Biomarker With A Smart Electrochemical Biosensor Based On Brush Polymer-Functionalized Disposable Electrode, Muhammet Aydin

Turkish Journal of Chemistry

A label-less impedimetric biosensor modified with poly(thiophene)-graft-poly(glycidyl methacrylate) polymer (PThi-g-PGM) was manufactured for p53 protein quantification in human serum samples. In this study, PThi-g-PGM polymer was synthesized, and this polymer matrix was coated using the spin-coating technique on the single-use indium tin oxide (ITO) substrate for anti-p53 antibody immobilization. The anti-p53 antibodies with high affinity for p53 proteins were covalently attached onto the PThi-g-PGM-coated electrode surface. In addition, the affinity of anti-p53 for the p53 protein was monitored at a constant frequency. Under optimized conditions, the impedimetric changes were linearly related to the p53 concentrations, ranging from 0.05 to 15 …

Dispersive Micro Solid Phase Extraction Of Cadmium On Mil-53(Al)@Batio3 Nanocomposite From Seafood Samples, Mustafa Soylak, Eda Bora, Furkan Uzcan

Turkish Journal of Chemistry

This study’s main goal was to produce a user-friendly dispersive micro solid phase extraction (dmSPE) technique with a MIL-53(Al)@BaTiO3 nanocomposite for the extraction and preconcentration of cadmium (Cd) in various seafood matrices, followed by using high-resolution continuum source flame atomic absorption spectrometry (HR-CS-FAAS). The MIL-53(Al)@BaTiO3 nanocomposite was synthesized and characterized using a range of techniques, including Fourier-transform infrared spectroscopy, field emission scanning electron microscopy, scanning transmission electron microscopy, X-ray diffraction, and Brunauer-Emmett-Teller analysis. The dmSPE technique involved the dispersion of the MIL-53(Al)@BaTiO3 material in the sample solution, followed by its separation from the sample matrix. The optimized method exhibited a …

Removal Of Heavy Metal Iron(Ii) Ions From Wastewater Using An Ultrasonic System With Climbazole-Alcohol, Melek Gökmen Karakaya, Bahdi̇şen Gezer, Abdullah Menzek, Özlem Gündoğdu Aytaç

Turkish Journal of Chemistry

Climbazole (CBZ) is an antifungal active pharmaceutical ingredient often used in antidandruff products. In this study, the ketone group in the racemic CBZ molecule was reduced to synthesize CBZ-alcohol, named 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-ol, and the optimum adsorption conditions were investigated for removing iron(II) (Fe2+) ions from wastewater by adsorption from aqueous solutions using the economical and environmentally friendly ultrasonic method. The parameters and levels used in the study were designed using response surface methodology and model equations were derived to optimize the results. The independent variables selected were the initial pH (1, 3, and 5), adsorption time (30, 45, and 60 min), …

1,3,4-Thiadiazole Derivatives As Pi3ks Inhibitor: Design, In Silico Studies, Synthesis, Characterization, And Antimicrobial Evaluation, Dharmvir Singh, Pankaj Kumar, Anoop Kumar, Vivek V. Bhosale, Kalicharan Sharma, Deepak Kumar, Ramchander Khatri, Tanuj Hooda, Amit Lather

Turkish Journal of Chemistry

Since PI3Ks are targeted by a variety of bacterial pathogens, they represent a promising target for host-directed immune therapy and may be beneficial in managing persistent bacterial infections. In the present study, computational studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives for phosphoinositide-3-kinases (PI3Ks) inhibitors were carried out using dock scores, Glide scores, and the MMGBSA dG method, with comparison to standard drugs (ofloxacin and fluconazole). A series of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives (D1-D17) were synthesized and evaluated for their in vitro antimicrobial activity against both gram-positive and gram-negative bacterial strains, as well as fungal strains, using the tube dilution method. The synthesized compounds were characterized …

Highly Sensitive And Selective Detection Of Klk4 In Human Serum With A Low-Cost Electrochemical Biosensor, Eli̇f Burcu Aydin

Turkish Journal of Chemistry

An ultrasensitive impedimetric immunosensor was fabricated using a poly(glycidyl methacrylate) (PGMA) polymer-covered indium tin oxide (ITO) platform for the quantification of kallikrein 4 (KLK4), an important prostate cancer biomarker. PGMA had suitable biocompatibility and nontoxicity for loading of antiKLK4 antibodies on the ITO substrate surface. Anti-KLK4 biomolecules were directly attached to the PGMA-covered electrode surface via epoxy groups of the PGMA polymer. The preparation method for the PGMA matrix-modified electrode was simple and inexpensive. The proposed biosensor immobilization layers coated on the ITO electrode were characterized with electrochemical techniques. The experimental parameters that affect biosensor response were optimized, and the …

Hmga2 Associated Cerna-Hotair Pathway In Breast Cancer Patients From Clinicopathological Perspective, Peli̇n Ercoşkun, Deni̇z Ağirbaşli, Mehmet Veli̇dedeoğlu, Mehmet Seven, Aysel Kalayci

Turkish Journal of Medical Sciences

Background/aim: Several epigenetic alterations are involved in the development of breast cancer. The long noncoding RNA HOTAIR and related RNAs play a role in initiation of breast cancer and are promising targets for diagnostic biomarker and therapeutic studies. In this study, we aimed to investigate HMGA2 associated ceRNA HOTAIR pathway in breast cancer patients.

Materials and methods: Forty breast cancer patients and ten healthy controls were included in this study, and then patients were divided into clinicopathologic groups. After total cell-free RNA isolation, expression levels of target RNAs were analysed by Real-Time PCR. The amount of gene expression was determined …

Janus Kinase Inhibitors In Localized Scleroderma: A Systematic Literature Review, Seher Şener, Yusuf Zi̇ya Şener, Ezgi̇ Deni̇z Batu, Alper Sari, Ali̇ Akdoğan

Turkish Journal of Medical Sciences

Background/aim: Reports on the use of Janus kinase (JAK) inhibitors in the treatment of localized scleroderma are increasing in the literature. In this review, we examined the published studies regarding the use of JAK inhibitors in patients with localized scleroderma.

Materials and methods: We searched MEDLINE and Scopus for articles on patients with localized scleroderma treated with JAK inhibitors. The search included articles from the inception of these databases through August 1st, 2024.

Results: Our literature search showed 11 articles describing 17 patients with localized scleroderma treated with JAK inhibitors. Generalized morphea (47.1%) was the most common type of localized …