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Isocoumarins And 3,4-Dihydroisocoumarins, Amazing Natural Products: A Review, Aisha Saddiqa, Osman Çakmak, Muhammad Usman
Isocoumarins And 3,4-Dihydroisocoumarins, Amazing Natural Products: A Review, Aisha Saddiqa, Osman Çakmak, Muhammad Usman
Turkish Journal of Chemistry
The isocoumarins are naturally occurring lactones that constitute an important class of natural products exhibiting an array of biological activities. A wide variety of these lactones have been isolated from natural sources and, due to their remarkable bioactivities and structural diversity, great attention has been focused on their synthesis. This review article focuses on their structural diversity, biological applications, and commonly used synthetic modes.
Synthesis And Anticancer And Cytotoxic Effects Of Novel 1,4-Phenylene-Bis-N-Thiocarbamoylpyrazole And 1,4-Phenylene-Bis-Pyrazolylthiazole Derivatives, Meli̇ha Burcu Gürdere, Erdoğan Kamo, Yakup Budak, Ayşe Şahi̇n Yağlioğlu, Mustafa Ceylan
Synthesis And Anticancer And Cytotoxic Effects Of Novel 1,4-Phenylene-Bis-N-Thiocarbamoylpyrazole And 1,4-Phenylene-Bis-Pyrazolylthiazole Derivatives, Meli̇ha Burcu Gürdere, Erdoğan Kamo, Yakup Budak, Ayşe Şahi̇n Yağlioğlu, Mustafa Ceylan
Turkish Journal of Chemistry
Thiazolylpyrazoline derivatives were recently reported as potent anticancer agents. In this study, novel 1,4-phenylene-bis-N-thiocarbamoylpyrazoles (3a-h and 1,4-phenylene-bis-pyrazolylthiazoles (5a-h were prepared and screened for their anticancer activities against C6 (rat brain tumor cells) and HeLa (human uterus carcinoma). Anticancer activity studies were performed as a dose-dependent assay starting with eight concentrations. 5-Fluorouracil (5-FU) was used as a positive control. Compounds 3c, 3d, and 3h were examined and they revealed almost the same activities compared with 5-FU in terms of cell selectivity against C6 cells. Moreover, compounds 3a-h had lower cytotoxicity than 5-FU. The low cytotoxicity values of 3a-h as well as …
Efficient Multicomponent Synthesis Of 1,2,3-Triazoles Catalyzed By Cu(Ii) Supported On Pei@Fe$_{3}$O$_{4}$ Mnps In A Water/Peg$_{300}$ System, Zeinab Hassanpour, Aziz Maleki, Morteza Hosseini, Lena Gorgannezhad, Vajihe Nejadshafiee, Ali Ramazani, Ismaeil Haririan, Abbas Shafiee, Mehdi Khoobi
Efficient Multicomponent Synthesis Of 1,2,3-Triazoles Catalyzed By Cu(Ii) Supported On Pei@Fe$_{3}$O$_{4}$ Mnps In A Water/Peg$_{300}$ System, Zeinab Hassanpour, Aziz Maleki, Morteza Hosseini, Lena Gorgannezhad, Vajihe Nejadshafiee, Ali Ramazani, Ismaeil Haririan, Abbas Shafiee, Mehdi Khoobi
Turkish Journal of Chemistry
A highly dispersible and magnetically recoverable Cu-PEI@Fe$_{3}$O$_{4}$ MNPs catalyst was prepared and successfully applied in one-pot three-component coupling of terminal alkynes, sodium azide, and alkyl bromides/chlorides in water to give 1,4-disubstituted 1,2,3-triazoles with good to excellent yields. The catalyst was fully characterized with FT-IR, TGA, TEM, SEM, VSM, EDX, cyclic voltammetry, and ICP-AES spectroscopic techniques. Furthermore, the catalyst was easily recycled by an external magnet and successfully reused six times in the reaction without significant loss of its catalytic activity and copper leaching. The large-scale reaction was also carried out in the absence of any base and reducing agent even …
Development Of A Sample Preparation Strategy For The Determination Of Tungsten In Soil Samples By Inductively Coupled Plasma Mass Spectrometry Using A Response Surface Methodology, Ümran Seven Erdemi̇r
Development Of A Sample Preparation Strategy For The Determination Of Tungsten In Soil Samples By Inductively Coupled Plasma Mass Spectrometry Using A Response Surface Methodology, Ümran Seven Erdemi̇r
Turkish Journal of Chemistry
An alternative rapid digestion method has been developed for the determination of tungsten (W) in soil samples using fractionation studies and response surface methodology. The digestion method using the Kjeldahl instrument was applied to samples, and soluble tungsten was determined via inductively coupled plasma mass spectrometry. Digestion parameters were selected depending on the results of fractionation studies and optimized using a four-factor and five-level central composite design. The contributions of the phosphoric acid concentration (X$_{1})$, digestion temperature (X$_{2})$, digestion time (X$_{3})$, and hydrochloric acid concentration (X$_{4})$ were evaluated for the determination of W from samples in which its levels were …
Synthesis, Characterization, And Antimicrobial Activities Of Novel Monosaccharide-Containing Schiff Base Ligands, Fatma Telli̇, Stephen Thomas Astley, Azi̇ze Yeşi̇m Salman
Synthesis, Characterization, And Antimicrobial Activities Of Novel Monosaccharide-Containing Schiff Base Ligands, Fatma Telli̇, Stephen Thomas Astley, Azi̇ze Yeşi̇m Salman
Turkish Journal of Chemistry
Four new chiral Schiff base ligands (3a-4a, 3b-4b) have been prepared using aminoisopropylidene derivatives of glucose and aminochloralose derivatives of mannose. The synthesized compounds 1 and 2 were characterized by nuclear magnetic resonance ($^{1}$H and $^{13}$C NMR), Fourier transform infrared spectroscopy (FTIR), UV/visible spectroscopy, and elemental analysis. A total of eight Schiff base compounds (3a-6a, 3b-6b) were tested for antimicrobial activity against Escherichia coli ATCC 12228, Staphylococcus aureus ATCC 6538, Klebsiella pneumoniae CCM 2318, Pseudomonas aeruginosa ATCC 27853, Salmonella typhimurium CCM 5445, Enterococcus faecalis ATCC 29212, Bacillus subtilis ATCC 6633, and Candida albicans ATCC 10239 and exhibited a range of …
Efficient Photodegradation Of Neutral Red Chloride Dye In Aqueous Medium Using Graphene/Cobalt-Manganese Oxides Nanocomposite, Khalid Saeed, Idrees Khan
Efficient Photodegradation Of Neutral Red Chloride Dye In Aqueous Medium Using Graphene/Cobalt-Manganese Oxides Nanocomposite, Khalid Saeed, Idrees Khan
Turkish Journal of Chemistry
Graphene/cobalt-manganese oxides nanocomposites were prepared from their precursor through chemical reduction where NaOH was used as a reducing agent. The obtained GNs/Co-Mn nanocomposites were used as photocatalyst for the photodegradation of Neutral Red Chloride (NRC) dye in aqueous solution under sunlight as a function of time and catalyst dosage. The morphology and photodegradation study was carried out using scanning electron microscopy (SEM) and UV-VIS spectrophotometry, respectively. The SEM image showed the presence of Co-Mn nanoparticles on the surface of GNs, which were also confirmed by energy dispersive X-ray analysis. The photodegradation study of NRC showed that the degradation of dye …
Bis(Indoline-2,3-Diones): Versatile Precursors For Novel Bis(Spirooxindoles) Incorporating 4$H$-Chromene-3-Carbonitrile And Pyrano[2,3-$D$]Pyrimidine-6-Carbonitrile Derivatives, Said Ahmed Soliman Ghozlan, Muhammed Aly Ramadan, Amr Mohmed Abdelmoniem, Ahmed H. M. Elwahy, Ismail Abdelshafy Abdelhamid
Bis(Indoline-2,3-Diones): Versatile Precursors For Novel Bis(Spirooxindoles) Incorporating 4$H$-Chromene-3-Carbonitrile And Pyrano[2,3-$D$]Pyrimidine-6-Carbonitrile Derivatives, Said Ahmed Soliman Ghozlan, Muhammed Aly Ramadan, Amr Mohmed Abdelmoniem, Ahmed H. M. Elwahy, Ismail Abdelshafy Abdelhamid
Turkish Journal of Chemistry
Multicomponent reaction of dimedone or 1,3-dimethylbarbituric acid and malononitrile with a series of bis(indoline-2,3-diones) afforded the corresponding bis(2-amino-7,7-dimethyl-2',5-dioxo-5,6,7,8-tetrahydrospiro[chromene-4,3'-indoline]-3-carbonitrile) and bis(7'-amino-1',3'-dimethyl-2,2',4'-trioxo-1',2',3',4'-tetrahydrospiro[indoline-3,5'-pyrano [2,3-d]pyrimidine]-6'-carbonitrile) derivatives in good to excellent yield.
A Biochar-Modified Carbon Paste Electrode, Derya Bal Altuntaş, Gökçen Akgül, Jale Yanik, Ülkü Anik
A Biochar-Modified Carbon Paste Electrode, Derya Bal Altuntaş, Gökçen Akgül, Jale Yanik, Ülkü Anik
Turkish Journal of Chemistry
The present work examıned the use of biochar derived from tea waste as a novel electrode material. For the fabrication of the biochar electrode, suitable amounts of biochar and graphite were mixed with mineral oil for the first time. The electrochemical performance of the biochar-modified carbon paste electrode (BCPE) was measured by various cyclic voltammetric reactions for several redox systems. The factors affecting the electrode kinetics of BCPE surfaces were examined and optimized. The BCPE was applied as transducer in a glucose biosensor. The results reflect the effective properties of composite electrodes and the electrochemical properties of biochar showing that …
Achieving Elusive Transformations With Organocatalysis: Direct $\Beta $-Carbon Activation Of Saturated Carbonyl Compounds, Rafik Rajjak Shaikh
Achieving Elusive Transformations With Organocatalysis: Direct $\Beta $-Carbon Activation Of Saturated Carbonyl Compounds, Rafik Rajjak Shaikh
Turkish Journal of Chemistry
Direct $\beta $-carbon activation of saturated carbonyl compounds for carrying out fast forward $\beta$-functionalization has been one of the most difficult to achieve tasks in catalysis. In the past few years, this challenging issue has attracted considerable attention among the chemical community that has led to fruitful developments to accomplish this elusive transformation. In this short review, we highlight recent developments for direct $\beta $-carbon functionalization of saturated carbonyl compounds based on conceptually new methods including oxidative enamine catalysis, $N$-heterocyclic carbene (NHC)-assisted catalysis, and photoredox catalysis.
A New Method For Simultaneous Determination Of Trace Amounts Of Cu(Ii) And Ni(Ii) Ions By Preconcentration And Spectrophotometric Analysis, Berri̇n Topuz, Şennur Merve Adanur, Arda Yalçuk
A New Method For Simultaneous Determination Of Trace Amounts Of Cu(Ii) And Ni(Ii) Ions By Preconcentration And Spectrophotometric Analysis, Berri̇n Topuz, Şennur Merve Adanur, Arda Yalçuk
Turkish Journal of Chemistry
Immediate preconcentration and spectrophotometric methods have been developed for the determination of trace amounts of cupric ion (Cu(II)) and nickel ion (Ni(II)) through a solid phase extraction with XAD-4-N,N'-bis-(salicylidene) cyclohexanediamine (XAD-4-SCHD) resin and a complex color reaction of the ions with 2,6-dimethyl-morpholine dithiocarbamate (DMMDTC) in Triton X-100 media. A high preconcentration factor of 125 was achieved. The spectrophotometric method was based on the measurements of the absorption of colored chelates of ions complexing with DMMDTC, and the adsorptions of the complex solutions were measured at their maximum absorption peaks at 460 and 328 nm for Cu(II) and Ni(II) ions, respectively. …
Experimental And Computational Studies On The Absorption Properties Of Novel Formazan Derivatives, Gülşen Türkoğlu, M. Emi̇n Çinar
Experimental And Computational Studies On The Absorption Properties Of Novel Formazan Derivatives, Gülşen Türkoğlu, M. Emi̇n Çinar
Turkish Journal of Chemistry
Eight novel 3-(4-(benzyloxy)phenyl)-5-(4-bromophenyl)-1-(4-substituted-phenyl)formazan (4a-4h) were synthesized by coupling of substituted phenylhydrazones with diazonium salts of 4-bromoaniline. The substituted phenylhydrazones, which are intermediate products, were obtained from the condensation of substituted phenylhydrazines with 4-(benzyloxy)benzaldehyde. All target compounds were characterized by using FTIR, $^{1}$H NMR, $^{13}$C NMR, LC$-$MS spectrometry, and elemental analysis. Absorption spectra of these compounds in solvents with different polarities were investigated thoroughly. Time-dependent density functional theory (TD-DFT) studies were conducted to shed light on their electronic structures, Kohn--Sham orbitals, and electronic transitions.
Synthesis, In Vitro Dna Interactions, Cytotoxicities, Antioxidative Activities, And Topoisomerase Inhibition Potentials Of Mn(Ii), Co(Ii), Ni(Ii), Cu(Ii), And Zn(Ii) Complexes With Azo-Oxime Ligands, Melek Çol Ayvaz, İbrahi̇m Turan, Bayram Dural, Seli̇m Demi̇r, Kaan Karaoğlu, Yüksel Ali̇yazicioğlu, Keri̇m Serbest
Synthesis, In Vitro Dna Interactions, Cytotoxicities, Antioxidative Activities, And Topoisomerase Inhibition Potentials Of Mn(Ii), Co(Ii), Ni(Ii), Cu(Ii), And Zn(Ii) Complexes With Azo-Oxime Ligands, Melek Çol Ayvaz, İbrahi̇m Turan, Bayram Dural, Seli̇m Demi̇r, Kaan Karaoğlu, Yüksel Ali̇yazicioğlu, Keri̇m Serbest
Turkish Journal of Chemistry
Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) transition metal complexes of 2-hydroxy-5-[(E)-(4-phenyl) diazenyl] benzaldehyde oxime and 2-hydroxy-5-[(E)-(4-nitrophenyl) diazenyl] benzaldehyde oxime ligands were synthesized and characterized through NMR, IR, ESI mass, and UV analysis. DNA binding abilities of the complexes were revealed using a UV-Vis spectrophotometer with the absorption titration and competitive binding techniques. Hydrolytic and oxidative DNA cleavage activities under different conditions were also proved. Topoisomerase I inhibition efficiencies and in vitro free radical scavenging activities of all complexes were examined. Finally, the selective cytotoxic potentials of all complexes were evaluated in human colon cancer, normal colon, and fibroblast cell lines …
Heuristic Algorithm-Based Estimation Of Rotor Resistance Of An Induction Machine By Slot Parameters With Experimental Verification, Mehmet Çelebi̇, Murat Tören
Heuristic Algorithm-Based Estimation Of Rotor Resistance Of An Induction Machine By Slot Parameters With Experimental Verification, Mehmet Çelebi̇, Murat Tören
Turkish Journal of Electrical Engineering and Computer Sciences
The estimations of induction machine equivalent circuit parameters are still being widely used in the analysis and in determining the characteristics of the machine. Since the most important part of the machine is the rotor where torque is produced, the calculation of rotor resistance correctly will directly affect all other data. Almost all parameters belonging to the stator side can easily be determined through external measurements. However, due to the formulation of the rotor as a closed box, estimating rotor resistance and the rotor's slot shape by heuristic algorithms, without damaging the rotor physically, and comparing it with its actual …
A New Word-Based Compression Model Allowing Compressed Pattern Matching, Hali̇l Nusret Buluş, Aydin Carus, Altan Mesut
A New Word-Based Compression Model Allowing Compressed Pattern Matching, Hali̇l Nusret Buluş, Aydin Carus, Altan Mesut
Turkish Journal of Electrical Engineering and Computer Sciences
In this study a new semistatic data compression model that has a fast coding process and that allows compressed pattern matching is introduced. The name of the proposed model is chosen as tagged word-based compression algorithm (TWBCA) since it has a word-based coding and word-based compressed matching algorithm. The model has two phases. In the first phase a dictionary is constructed by adding a phrase, paying attention to word boundaries, and in the second phase compression is done by using codewords of phrases in this dictionary. The first byte of the codeword determines whether the word is compressed or not. …
Prognosis Of Muscular Dystrophy With Extrinsic And Intrinsic Descriptors Through Ensemble Learning, Sathyavikasini Kalimuthu, Vijaya Vijayakumar
Prognosis Of Muscular Dystrophy With Extrinsic And Intrinsic Descriptors Through Ensemble Learning, Sathyavikasini Kalimuthu, Vijaya Vijayakumar
Turkish Journal of Electrical Engineering and Computer Sciences
Muscular dystrophy is a neuromuscular disorder that impairs the functioning of the locomotive muscles. Large deletion and duplication mutations in the gene sequences pave the way for these muscular dystrophies. Any heritable change can be used as input in computational studies such as pattern and classification models. Mutated gene sequences are generated by adopting the positional cloning approach on the reference cDNA sequence with mutational information from the Human Gene Mutational Database (HGMD). The extrinsic and intrinsic descriptors of the mutated gene sequence are indispensable to identifying the disease. This work describes a computational approach of building a disease classification …
Concurrent Optimal Design Of Tcsc And Pss Using Symbiotic Organisms Search Algorithm, Muwaffaq Alomoush
Concurrent Optimal Design Of Tcsc And Pss Using Symbiotic Organisms Search Algorithm, Muwaffaq Alomoush
Turkish Journal of Electrical Engineering and Computer Sciences
The symbiotic organisms search (SOS), which has been recently introduced, is a robust powerful metaheuristic global optimizer. This nature-inspired algorithm imitates the symbiotic interaction strategies in an ecosystem exercised by organisms involved in interrelationships to survive and reproduce. One of the main beneficial features of the SOS in contrast to many other competent metaheuristic algorithms is that the algorithm does not need any specific algorithm parameters or tuning process. This paper applies the SOS algorithm to simultaneously design optimal controllers of a power system equipped with both a power system stabilizer (PSS) and a thyristor-controlled series compensator (TCSC). The algorithm …
Multiobjective Distributed Model Predictive Control Method For Facility Environment Control Based On Cooperative Game Theory, Huanliang Xu, Zhaoyu Zhai, Ke Wang, Shougang Ren, Haoyun Wang
Multiobjective Distributed Model Predictive Control Method For Facility Environment Control Based On Cooperative Game Theory, Huanliang Xu, Zhaoyu Zhai, Ke Wang, Shougang Ren, Haoyun Wang
Turkish Journal of Electrical Engineering and Computer Sciences
In order to achieve better control performance within the facility environment, this paper proposes a distributed model predictive control method, aiming at increasing the control precision of actuators, reducing energy consumption and equipment loss at the same time. Regarding optimizing this facility environment model, it could be treated as a multiobjective optimization problem. Referring to the cooperative game theory, each objective is regarded as a gamer. Each gamer considers both its own interests and other gamers' interests to achieve a balanced result when cooperation is achieved. The simulation experiments illustrate that the proposed control method is able to adjust the …
Breast-Region Segmentation In Mri Using Chest Region Atlas And Svm, Aida Fooladivanda, Shahriar Baradaran Shokouhi, Nasrin Ahmadinejad
Breast-Region Segmentation In Mri Using Chest Region Atlas And Svm, Aida Fooladivanda, Shahriar Baradaran Shokouhi, Nasrin Ahmadinejad
Turkish Journal of Electrical Engineering and Computer Sciences
An important step for computerized analysis of breast magnetic resonance imaging (MRI) is segmentation of the breast region. Due to the similar signal intensity of fibroglandular tissue and the chest wall, the segmentation process is difficult for breasts with fibroglandular tissue connected to the chest wall. In order to overcome this challenge, a new framework is presented that relies on a chest region atlas. The proposed method first detects the approximated breast-chest wall boundary using an intensity-based operation. A support vector machine (SVM) then determines the connectivity of fibroglandular tissue to the chest wall by the extracted features from the …
Power Search Algorithm (Psa) For Combined Economic-Emission Dispatch Problems Considering Valve Point Effects In Economic Load Dispatch, Prakash Arumugam, Ravichandran Coimbatore Subramanian
Power Search Algorithm (Psa) For Combined Economic-Emission Dispatch Problems Considering Valve Point Effects In Economic Load Dispatch, Prakash Arumugam, Ravichandran Coimbatore Subramanian
Turkish Journal of Electrical Engineering and Computer Sciences
Economic load dispatch has become the prime and major concern in power system networks. Use of nonrenewable fuels as an input to power systems results in toxic gas emission and depletion of resources for future generations. Allocation of optimal power to generators serves as a solution to this issue. The suggested power search algorithm (PSA) is a novel solution for the reduction of the fuel cost, emissions, and power loss. This algorithm searches its solution inside the search space from minimum to maximum in case of forward search. The global optimum solution is obtained with much less execution time compared …
Neoteric Chaff Generation Method Of Fingerprint Fuzzy Vault, Nancy Singla, Sanjeev Sofat, Manvjeet Kaur
Neoteric Chaff Generation Method Of Fingerprint Fuzzy Vault, Nancy Singla, Sanjeev Sofat, Manvjeet Kaur
Turkish Journal of Electrical Engineering and Computer Sciences
Authentication using biometrics has an edge over traditional authentication mechanisms. Fuzzy vault is an eminent biometric cryptosystem technique that aims to protect a secret using a biometric template. Authorized users can, however, access the secret by providing the valid biometric. In a fuzzy vault, noise is incorporated in the form of chaff points in order to increase the security. While implementing fuzzy vault schemes in real scenarios, the most critical but computing-intensive and time-consuming task is chaff generation. In this paper, a neoteric method for chaff generation is proposed, which is less time-consuming in generating large numbers of chaff points.
A Cooperative Neural Network Approach For Enhancing Data Traffic Prediction, Salihu Aish Abdulkarim, Isa Abdullahi Lawal
A Cooperative Neural Network Approach For Enhancing Data Traffic Prediction, Salihu Aish Abdulkarim, Isa Abdullahi Lawal
Turkish Journal of Electrical Engineering and Computer Sciences
This paper addresses the problem of learning a regression model for the prediction of data traffic in a cellular network. We proposed a cooperative learning strategy that involves two Jordan recurrent neural networks (JNNs) trained using the firefly algorithm (FFA) and resilient backpropagation algorithm (Rprop), respectively. While the cooperative capability of the learning process ensures the effectiveness of the regression model, the recurrent nature of the neural networks allows the model to handle temporally evolving data. Experiments were carried out to evaluate the proposed approach using high-speed downlink packet access data demand and throughput measurements collected from different cell sites …
An Improved Omthd Technique For An N-Level Cascaded Multilevel Inverter With Adjustable Dc Sources, Hamidreza Toodeji
An Improved Omthd Technique For An N-Level Cascaded Multilevel Inverter With Adjustable Dc Sources, Hamidreza Toodeji
Turkish Journal of Electrical Engineering and Computer Sciences
Optimal minimization of total harmonic distortion (OMTHD) and selective harmonic elimination (SHE) switching techniques are usually employed to reduce generated harmonics of multilevel inverters. In the former technique, the THD of waveform is reduced without elimination of any harmonic order and the latter, in contrast, eliminates selected harmonic orders. In this paper, the harmonic elimination ability of the SHE technique is added to OMTHD and an improved OMTHD technique is proposed for an n-level cascaded multilevel inverter with adjustable DC sources. The main novelty of this switching technique is elimination of some harmonic orders, beside THD minimization. Moreover, optimal DC …
Transcription Factor 7-Like 2 (Tcf7l2) Gene Polymorphisms Are Strong Predictorsof Type 2 Diabetes Among Nonobese Diabetics In The Turkish Population, Dudu Erkoç Kaya, Hi̇lal Arikoğlu, Seyi̇t Ali̇ Kayiş, Onur Öztürk, Mustafa Sai̇t Gönen
Transcription Factor 7-Like 2 (Tcf7l2) Gene Polymorphisms Are Strong Predictorsof Type 2 Diabetes Among Nonobese Diabetics In The Turkish Population, Dudu Erkoç Kaya, Hi̇lal Arikoğlu, Seyi̇t Ali̇ Kayiş, Onur Öztürk, Mustafa Sai̇t Gönen
Turkish Journal of Medical Sciences
Background/aim: Type 2 diabetes (T2D) is a multifactorial disease, determined by environmental and genetic factors. Currently, the transcription factor 7-like 2 (TCF7L2) gene shows the strongest association with T2D. In this study, we investigated whether TCF7L2 gene polymorphisms are associated with T2D in a Turkish population. Materials and methods: Using PCR-RFLP and PCR-SSCP, we genotyped six intronic polymorphisms in the TCF7L2 gene, commonly associated with T2D, in 169 individuals with diabetes and 119 healthy controls. Results: We found that rs7903146 C -> T substitution in intron 3 (OR: 1.9, P = 0.005) and rs12255372 G -> T substitution in intron …
Is There Any Difference In Tetanus Igg Levels Of Diabetic Patientswith Respect To The Presence Of Foot Ulcers?, Fati̇h Teki̇n, Mehmet Sürmeli̇, Zeynep Çi̇zmeci̇, Özlem Teki̇n, Ergi̇n Işik, Ömer Faruk Taner, Derun Taner Ertuğrul
Is There Any Difference In Tetanus Igg Levels Of Diabetic Patientswith Respect To The Presence Of Foot Ulcers?, Fati̇h Teki̇n, Mehmet Sürmeli̇, Zeynep Çi̇zmeci̇, Özlem Teki̇n, Ergi̇n Işik, Ömer Faruk Taner, Derun Taner Ertuğrul
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to reveal the tetanus immunization status of diabetic patients and to determine whether diabetic patients with foot ulcers have different TIG levels. Materials and methods: A cross-sectional study was designed that included diabetic patients with foot ulcers (n = 30) and diabetic patients without ulcers (n = 30). The groups were compared for serum TIG levels along with total serum protein, albumin, C-reactive protein (CRP), and total immunoglobulin G (Ig G). Results: For diabetic patients without foot ulcers, 17 of 30 (56.6%) patients were found to have nonprotective TIG levels whereas for diabetic …
Sex-Related Differences In Copd Assessment Test Scores Of Copd Populationswith Or Without Significant Anxiety And/Or Depression, Yelda Varol, Ceyda Anar, Pinar Çi̇men, Mehmet Ünlü, Hüseyi̇n Hali̇lçolar, Sali̇h Zeki̇ Güçlü
Sex-Related Differences In Copd Assessment Test Scores Of Copd Populationswith Or Without Significant Anxiety And/Or Depression, Yelda Varol, Ceyda Anar, Pinar Çi̇men, Mehmet Ünlü, Hüseyi̇n Hali̇lçolar, Sali̇h Zeki̇ Güçlü
Turkish Journal of Medical Sciences
Background/aim: Sex-related differences have not been thoroughly explored in chronic obstructive pulmonary disease (COPD). We aimed to evaluate possible sex-related differences in COPD Assessment Test (CAT) scores of COPD patients with or without significant anxiety and/or depression. Materials and methods: Stable COPD patients were prospectively enrolled in the study between July 2013 and April 2014. Levels of anxiety, depression, dyspnea, and health-related quality of life parameters were assessed using specific questionnaires, including the CAT and others. Demographic and clinical data were recorded and physiological tests were performed. All the data were compared to determine any sex-related differences. Results: A total …
Nitric Oxide In Cerebrospinal Fluid Of Central Nervous System Tuberculosis: Correlations With Culture, Antibody Response, And Cell Count, Kavitha Kumar, Prashant Giribhattanavar, Shripad Patil
Nitric Oxide In Cerebrospinal Fluid Of Central Nervous System Tuberculosis: Correlations With Culture, Antibody Response, And Cell Count, Kavitha Kumar, Prashant Giribhattanavar, Shripad Patil
Turkish Journal of Medical Sciences
Background/aim: The role of nitric oxide (NO) has been established in infection over the years. NO functions by inhibiting the growth of intracellular pathogens. The present study was undertaken to ascertain the role of NO in central nervous system (CNS) infection by Mycobacterium tuberculosis. Materials and methods: A total of 781 chronic meningitis cerebrospinal fluid (CSF) samples suspected of CNS tuberculosis (TB) were categorized based on M. tuberculosis culture positivity, anti-TB antibody response, and CSF cell count and were analyzed for NO. Results: We found that NO levels were positive in 10.88% of the CSF samples. Positivity for NO was …
Significant Association Between Scgb1d4 Gene Polymorphisms And Susceptibility To Adenoid Hypertrophy In A Pediatric Population, Tali̇h Özdaş, Si̇bel Özdaş, Mehmet Ali̇ Babademez, Sami̇ Engi̇n Muz, Mahmut Huntürk Ati̇lla, Si̇bel Başti̇mur, Afi̇fe İzbirak, Kenan Kurt, Işilay Öz
Significant Association Between Scgb1d4 Gene Polymorphisms And Susceptibility To Adenoid Hypertrophy In A Pediatric Population, Tali̇h Özdaş, Si̇bel Özdaş, Mehmet Ali̇ Babademez, Sami̇ Engi̇n Muz, Mahmut Huntürk Ati̇lla, Si̇bel Başti̇mur, Afi̇fe İzbirak, Kenan Kurt, Işilay Öz
Turkish Journal of Medical Sciences
Background/aim: Adenoid hypertrophy (AH) is chronic enlargement of the adenoid tissue. The pathophysiology of the disease is unclear. We analyzed SCGB1D4 gene polymorphisms in order to determine the effect of the variants or their genetic combinations on AH. Materials and methods: We genotyped the SCGB1D4 (IIS) gene in 167 participants (95 children with AH and 72 controls) by performing DNA sequencing in blood samples. Results: We genotyped three single nucleotide polymorphisms (SNPs). In the analysis, we found that in the presence of those SNPs and the minor alleles of individual SNPs four haplotypes were associated with an increased risk of …
A Novel Mutation In Exon 1 Of Gata4 In Egyptian Patients With Congenital Heart Disease, Olfat Shaker, Salwa Omran, Eman Sharaf, Gehan A. Hegazy, Mohamed Mashaly, Nagwa E.A. Gaboon
A Novel Mutation In Exon 1 Of Gata4 In Egyptian Patients With Congenital Heart Disease, Olfat Shaker, Salwa Omran, Eman Sharaf, Gehan A. Hegazy, Mohamed Mashaly, Nagwa E.A. Gaboon
Turkish Journal of Medical Sciences
Background/aim: Congenital heart disease (CHD) is a common birth defect. Many studies have reported GATA4 mutations in patients with CHD, mainly septal defects. This study aimed to investigate the GATA4 exon 1 mutation in Egyptian patients with isolated congenital heart defects as a possible causative mutation. Materials and methods: Screening for mutations or any sequence variations in exon 1 of the GATA4 gene was carried out by PCR amplification followed by direct sequencings in 165 Egyptian patients with different nonsyndromic congenital heart diseases and 93 controls who were matched in terms of age and sex. Thorough clinical assessments were done …
Physicochemical And Biochemical Parameters In Milk Of Serbian Breastfeeding Women, Slavica Sunaric, Marko Denic, Jelena Lalic, Tatjana Jovanovic, Ana Spasic, Jelena Zivkovic, Natasa Trutic, Gordana Kocic
Physicochemical And Biochemical Parameters In Milk Of Serbian Breastfeeding Women, Slavica Sunaric, Marko Denic, Jelena Lalic, Tatjana Jovanovic, Ana Spasic, Jelena Zivkovic, Natasa Trutic, Gordana Kocic
Turkish Journal of Medical Sciences
Background/aim: This study was undertaken to determine the changes and relationships between some important milk constituents as well as physical, rheological, and biochemical parameters of milk obtained from Serbian breastfeeding mothers. Materials and methods: Physicochemical and biochemical parameters and the concentrations of vitamins, uric acid, and minerals were determined during the three periods of lactation covering colostrum, transitional, and mature milk collected from 67 mothers who had a term-pregnancy. Results: Large interindividual variations regarding many parameters were found between mothers at the same period of lactation, but the average values were mostly in the expected and recommended ranges. For some …
The Role Of Outer Inflammatory Protein A (Oipa) In Vaccination Of Thec57bl/6 Mouse Model Infected By Helicobacter Pylori, Mohaddese Mahboubi, Tahereh Falsafi, Majid Sadeghizadeh, Fatemeh Mahjoub
The Role Of Outer Inflammatory Protein A (Oipa) In Vaccination Of Thec57bl/6 Mouse Model Infected By Helicobacter Pylori, Mohaddese Mahboubi, Tahereh Falsafi, Majid Sadeghizadeh, Fatemeh Mahjoub
Turkish Journal of Medical Sciences
Background/aim: Outer inflammatory protein A (OipA) is an important adhesin of Helicobacter pylori. Our goal was to assess the role of OipA in protection of C57BL/6 mice against H. pylori. Materials and methods: C57BL/6 mice were mucosally immunized with recombinant OipA protein, OipA + propolis, propolis, and phosphate-buffered saline. After vaccination, anti-OipA IgA was measured. Mice were challenged three times with 5 x 107 CFU of the H. pylori B19 strain. Two weeks later, bacterial colonization and inflammation in the stomach was analyzed using standard methods. Results: The CFU number in the OipA group was significantly (P < 0.05) lower than that of the control. The CFU number in the OipA + propolis group was higher than those of the OipA and propolis groups. IgA titers were significantly higher (P < 0.0001) in the OipA group compared to the control and OipA + propolis groups. Propolis did not play an adjuvant effect but it interfered with the efficient vaccine effect of OipA. Conclusion: Results show the effect of vaccination by OipA in protection of the mouse model and the importance of OipA in H. pylori pathogenesis. OipA may be proposed as a suitable oral vaccine candidate against H. pylori infection; however, further study is required to determine adjuvant or adverse effects of propolis toward OipA.